Vol. 15 Issue 4 (2022)

VSKM 2022 N 4

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Achievements and prospects of development of departmental medicine of the internal affairs in the Republic of Tatarstan Fatykhov RG (Russia, Kazan), Sultanova DR (Russia, Kazan), Khalitov RI (Russia, Kazan), Frolov VV (Russia, Kazan), Amirov NB (Russia, Kazan) P. 7-11

ORIGINAL RESEARCH

Single-photon emission computed tomography in exercise tests in painless myocardial ischemia Abdrahmanova AI (Russia, Kazan), Tsibulkin NA (Russia, Kazan), Amirov NB (Russia, Kazan), Sayfullina GB (Russia, Kazan) P. 12-17

Genetic predictors of sarcoidosis course in Russian cohort. Balionis OI (Russia, Moscow), Nikitin AG (Russia, Moscow), Averyanov AV (Russia, Moscow) P.18-25

Analysis of the oncological state among the law enforcement authorities of the Sakha (Yakutia) in the 2019-2021 Dolinskaya EA (Russia, Yakutsk), Zakharova VA (Russia, Yakutsk), Gubko RV (Russia, Yakutsk), Zakharova IG (Russia, Yakutsk) P. 26-32

Clinical efficacy of Rengalin cough-suppressant therapy in patients with new coronavirus infection (COVID-19) Zaitsev AA (Russia, Moscow), Vizel AA (Russia, Kazan), Shakirova GR (Russia, Kazan), Kulagina ITs (Russia,  Moscow), Ternovskaya NA. (Russia, Moscow) P. 33-43

Treatment strategy of intolerance to thyroid-stimulating drugs in patients with Graves’ disease Krasil’nikov DM (Russia, Kazan), Valeeva FV (Russia, Kazan), Bareeva LT (Russia, Kazan), Shakulo AV (Russia, Kazan), Mirgasimova DM (Russia, Kazan), Zakharova AV (Russia, Kazan) P. 44-48

Relation between stenosis and calcification of coronary arteries in patients with coronary heart disease Fadeev GA (Russia, Kazan), Tsybulkin NA (Russia, Kazan), Zakirova EB (Russia, Kazan), Faizullina GG (Russia, Kazan) P. 49-53

Is it necessary to determine highly sensitive C-reactive protein in patients with chronic heart failure: clinical and prognostic aspects Hazova EV (Russia, Kazan), Bulashova OV (Russia, Kazan), Amirov NB (Russia,  Kazan) P. 54-59

Blood eosinophil count and COPD exacebrations: is it all straightforward Khamitov RF (Russia, Kazan), Zinnatullina AR (Russia, Kazan), Mihoparova OY (Russia, Kazan) P. 60-64

REVIEWS

Main aspects of engineering and technical design of buildings and issues of logistics and technical support of the bureau of forensic medical examination and pathologoanatomical departments from the point of view of the organization of sanitary-hygienic and anti-epidemic measures Vasiliev DE (Russia, Kazan) P. 65-69

COVID-19 and sarcoidosis: comorbidity, consequences, cause-and-effect relationships. Literature review Vizel AA (Russia, Kazan), Vizel IYu (Russia, Kazan), Shakirova GR (Russia, Kazan), Amirov NB (Russia,  Kazan) P. 70-79COVID-19 and sarcoidosis: comorbidity, consequences, cause-and-effect relationships. Literature review Vizel AA (Russia, Kazan), Vizel IYu (Russia, Kazan), Shakirova GR (Russia, Kazan), Amirov NB (Russia,  Kazan) P. 70-79

Contribution of occupational medicine to the prevention of harmful alcohol use Kuzmina SV (Russia, Kazan), Garipova RV (Russia, Kazan), Sultanova DR (Russia, Kazan) P. 80-85

On the possibility of use of adhesive surgical drapes Morozov AM (Russia, Tver), Sergeev AN (Russia, Tver), Morozova AD (Russia, Tver), Rachek AM (Russia, Solnechnogorsk),Kurkova VV (Russia, Tver), Semenova SM (Russia, Tver), Belyak MA (Russia, Tver), Nevostrueva AA (Russia, Tver) P. 86-93

Lower urinary tract infections (cystitis, bacteriuria) in outpatients practice: changing the strategy and tactics of empirical antimicrobial therapy (new clinical recommendation) Sigitova ON (Russia, Kazan), Kim TYu (Russia, Kazan), Khasanova MI (Russia, Kazan) P. 94-101

Application of the ERAS protocol in emergency surgery Sharipova VH (Uzbekistan, Tashkent), Bokiev KSh (Uzbekistan, Tashkent), Alimov AH. (Uzbekistan, Tashkent) P. 102-108 

ЕXPERIENCE EXCHANGE

New approaches in the treatment of patients with complicated destructive appendicitis Malkov IS (Russia, Kazan), Mamedov TA (Russia, Kazan), Shakirov MI (Russia, Kazan), Filippov VA (Russia, Kazan) P. 109-112

CLINICAL CASE

Clinical case of cestodosis of the right lobe of the liver Klyushkin IV (Russia, Kazan), Anisimov AYu (Russia, Kazan), Zakirova AM (Russia, Kazan) P. 113-123

HISTORY OF MEDICINE

Sergey Petrovich Botkin: to the jubilee of a doctor, a teacher, a researcher and public figure Zinkevich ER (Russia, St. Petersburg), Kulbach OS (Russia, St. Petersburg), Zavarzina NY (Russia, St. Petersburg) P. 124-130

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УДК: 61:351.74:616.98:616-039.78(470:41) DOI: 10.20969/VSKM.2022.15(4).7-11

PDF download ACHIEVEMENTS AND PROSPECTS OF DEVELOPMENT OF DEPARTMENTAL MEDICINE OF THE INTERNAL AFFAIRS IN THE REPUBLIC OF TATARSTAN

FATYKHOV RENAT G., ORCID ID: 0000-0001-5651-8341; Acting Head, Clinical hospital of Ministry of Internal Affairs of Russian Federation in Republic of Tatarstan, Russia, 420111, Kazan, st. Lobachevsky, 13, tel. +7 (843) 291-24-58, e-mail: rfatykhov5@mvd.ru

SULTANOVA DILYA R., ORCID ID: 0000-0001-7410-4898; colonel of the internal service, deputy head of the Clinical hospital of Ministry of Internal Affairs of Russian Federation in Republic of Tatarstan, Russia, 420111, Kazan, st. Lobachevsky, 13, tel. +7 (843) 291-32-14, e-mail: dsultanova@mvd.ru

KHALITOV RASHID IL., ORCID ID: 0000-0003-2966-5025; major of the internal service, head of the department for the examination of the quality of medical care of the organizational, methodological and treatment-and-prophylactic department of the Clinical hospital of Ministry of Internal Affairs of Russian Federation in Republic of Tatarstan, Russia, 420111, Kazan, st. Lobachevsky, 13, tel. +7 (843) 291-22-42, e-mail: rkhalitov11@mvd.ru

FROLOV VIKTOR V., ORCID ID: 0000-0003-2996-2978; senior lieutenant of the internal service, head of the organizational-methodical and treatment-and-prophylactic department of the Clinical hospital of Ministry of Internal Affairs of Russian Federation in Republic of Tatarstan, Russia, 420111, Kazan, st. Lobachevsky, 13, tel. +7 (843) 291-31-49, e-mail: vfrolov57@mvd.ru

AMIROV NAIL B., ORCID ID: 0000-0003-0009-9103; SCOPUS Authоr ID: 7005357664; D. Med. Sci., professor of the Department of outpatient medicine and general medical practice of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, Deputy Chief of Science, The Medical and Healthcare Unit of the Ministry of internal affairs of the Russian Federation in the Republic of Tatarstan, 420059, Kazan, Orenburg tract str., 132, tel.: +7 (843) 291-26-76, e-mail: namirov@mail.ru

Abstract. Introduction. The article reflects the results of the activities of the medical unit, as an institution in which the symbiosis of science and practice contributes to the fulfillment of tasks to preserve the health of employees of the internal affairs bodies. Attention is paid to the strategic goals of the institution and directions for improving the quality and accessibility of medical care. Aim. The purpose of the study is to present the achievements of the medical service of the Ministry of internal affairs in the Republic of Tatarstan and identify the primary tasks and our plans for the future, including the introduction of modern approaches to the organization of medical support for employees of internal affairs bodies. Material and methods.An analysis of the activities of the medical unit as a medical and preventive institution of a high level of medical care and the quality of medical care was carried out for the period from 2017 to 2022. Results and discussion. The implementation of various tasks in strengthening and maintaining the health of employees of the internal affairs bodies is carried out with the constant improvement of diagnostic and treatment methods, timely updating of equipment, close interaction with the departments of higher medical educational institutions, whose leading employees and teachers use the latest achievements of research activities in their work. Conclusion. The medical and sanitary unit of the Ministry of internal affairs for the Republic of Tatarstan continues to fulfill the tasks assigned to it, as a result of effective leadership, continuous improvement and continuous work to improve the availability and quality of medical care.

Key words: medical service of the Ministry of internal affairs for the Republic of Tatarstan, departmental medicine, medical unit.For reference: Fatykhov RG, Sultanova DR, Khalitov RI, Frolov VV, Amirov NB. Achievements and prospects of development of departmental medicine of the internal affairs in the Republic of Tatarstan. The Bulletin of Contemporary Clinical Medicine. 2022.15(4):7-11. DOI: 10.20969/VSKM.2022.15(4).7-11.

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ORIGINAL RESEARCH

УДК:616.127-005.4-073.756.8 DOI:10.20969/VSKM.2022.15(4).12-17

PDF download SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY IN EXERCISE TESTS IN PAINLESS MYOCARDIAL ISCHEMIA

ABDRAHMANOVA ALSU I., ORCID ID: 0000-0003-0769-3682; SCOPUS Author ID: 57192296744, C. Med. Sci., associate professor, Department of Internal Diseases, Institute of Biology and Fundamental Medicine of Kazan Federal University, Russia, 420012, Kazan, Karl Marx Str., 74; doctor of Interregional Clinical Diagnostic Center, Russia, 420089, Kazan, Karbyshev Str., 12а; e-mail: alsuchaa@mail.ru

TSIBULKIN NICOLAY A., ORCID ID: 0000-0002-1343-0478; C. Med. Sci., associate professor, Department of cardiology, roentgen-endovascular and cardiovascular surgery, Kazan State Medical Academy – the branch of Russian Medical Academy of Postgraduate Education, Russia, 420012, Kazan, Butlerov str., 36, e-mail: cardiokgma@mail.ru

AMIROV NAIL B., ORCID ID: 0000-0003-0009-9103; SCOPUS Author ID: 7005357664, D. Med. Sci, Professor, Department General Medical practice, Kazan State Medical University, 420012 Russia, Kazan, Butlerova Str., 49, e-mail: namirov@mail.ru

SAYFULLINA GUZEL B., ORCID ID: 0000-0002-1259-0285; doctor of Interregional Clinical Diagnostic Center, Russia, 420089, Kazan, Karbyshev Str., 12а, e-mail: sayfullina_rad@mail.ru

Abstract. Introduction. In the diagnosis of silent myocardial ischemia, single-photon emission computed tomography is of great importance. One of the methods for detecting silent myocardial ischemia is the assessment of its perfusion. For this, single-photon emission computed tomography is considered to be a highly sensitive method. It is the "gold standard" in the diagnosis of transient myocardial ischemia due to both coronary and non-coronary causes. Aim. The aim of the study was to analyze the data of single-photon emission computed tomography at rest and after a stress test in patients with silent myocardial ischemia and the usual form of angina pectoris. Material and methods. 78 case histories of patients with silent and ordinary myocardial ischemia were analyzed. Bicycle ergometry was used as a stress test. The dynamics of perfusion, contractility and electrocardiographic picture were evaluated. Statistical analysis was carried out using parametric and nonparametric criteria.Results and discussion. Patients with silent myocardial ischemia are signi cantly less likely to undergo coronary stenting and coronary bypass grafting compared to the group with typical angina pectoris. The most common reason for stopping the exercise test in the group with silent myocardial ischemia is ST depression, which occurs 6 times more often than in patients with the usual form of angina. In the group with silent myocardial ischemia, a decrease in myocardial contractility is observed 20% more often, 2.5 times less often there are ventricular extrasystole, 3 times more often there is a hypertonic type of reaction to physical activity than in patients with the usual form of angina pectoris. Conclusion. Single photon emission computed tomography using stress tests reveals differences in patients with silent and ordinary forms of myocardial ischemia.

Key words: silent myocardial ischemia, single-photon emission computed tomography.

For reference: Abdrahmanova AI, Tsibulkin NA, Amirov NB, Sayfullina GB. Single-photon emission computed tomography in exercise tests in painless myocardial ischemia. The Bulletin of Contemporary Clinical Medicine. 2022; 15(4):12-17. DOI:

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11. Патеюк И.В., Митьковская Н.П., Терехов В.И. и др. Однофотонная эмиссионная компьютерная томография и скрининг коронарного кальция в диагностике ишемии миокарда и стратификации риска у пациентов с бессимптомной депрессией сегмента ST //Лечебное дело: научно -практический терапевтический журнал. – 2015. – Т. 45, вып. 5. – С. 33–37. [Pateyuk IV, Mitkovskaya NP, Terekhov VI, et al. Single-photon emission computed tomography and coronary calcium screening in the diagnosis of myocardial ischemia and risk strati cation in asymptomatic ST-segment depression patients [Single photon emission computed tomography and coronary calcium screening in the diagnosis of myocardial ischemia and risk strati cation in patients with asymptomatic ST segment depression]. General medicine [Medical business]. 2015; 45 (5): 33-37. (In Russ.)].

12. Абдрахманова А.И., Сайфуллина Г.Б., Амиров Н.Б. Место перфузионной сцинтиграфии миокарда в диагностике синдрома такоцубо // Российский кардиологический журнал. – 2018. – No12. – С. 125–130. [Abdrakhmanova AI, Sayfullina GB, Amirov NB. The place of myocardial perfusion scintigraphy in the diagnosis of takotsubo syndrome [Place of myocardial perfusion scintigraphy in the diagnosis of takotsubo syndrome]. Russian journal of cardiology [Russian Journal of Cardiology]. 2018; 12: 125-130 (In Russ.)]. DOI: 10.15829/1560-4071-2018-12-125-130

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15. Рыжкова Д.В., Салахова А.Р. Технические основы и клиническое применение позитронной эмиссионной томографии для оценки перфузии миокарда как самостоятельной процедуры и в составе гибридных систем //Трансляционная медицина. – 2015. – No5. – С. 113-122. [Ryzhkova DV, Salakhova AR. Technical fundamentals and clinical application of positron emission tomography for the assessment of myocardial perfusion as an independent procedure and as part of hybrid systems [Technical foundations and clinical application of positron emission tomography for assessing myocardial perfusion as an independent procedure and as part of hybrid systems]. Translational medicine [Translational medicine]. 2015; 5: 113-122 (In Russ.)]. DOI: 10.18705/2311-4495-2015-0-5-113-122

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22. Абдрахманова А.И., Амиров Н.Б., Цибулькин Н.А. Применение перфузионной томосцинтиграфии миокарда при безболевой ишемии миокарда (обзор литературы) // Архивъ внутренней медицины. – 2020. – Т. 5, вып. 5. — С. 340-347. [Abdrakhmanova AI, Amirov NB, Tsibulkin NA. The use of myocardial perfusion tomoscintigraphy in painless myocardial ischemia (literature review) [The use of myocardial perfusion tomoscintigraphy in painless myocardial ischemia (literature review)]. Archive of Internal Medicine [Archives of Internal Medicine]. 2020; 10 (5): 340-347. (In Russ.)]. DOI: 10.20514/2226-6704-2020-10-5-340-347

23. Кузнецов В.А., Ярославская Е.И., Горбатенко Е.А. Предикторы гемодинамически значимых коронарных стенозов у пациентов с нарушениями миокардиальной перфузии по данным однофотонной эмиссионной компьютерной томографии миокарда //Клиническая медицина. – 2012. – No7. — С. 25-30. [Kuznetsov VA, Yaroslavskaya EI, Gorbatenko EA. Predictors of hemo-dynamically signi cant coronary stenoses in patients with myocardial perfusion disorders according to single-photon emission computed tomography of the myocardium [Predictors of hemodynamically signi cant coronary stenoses in patients with impaired myocardial perfusion according to single photon emission computed tomography of the myocardium]. Clinical medicine [Clinical medicine]. 2012; 7: 25-30. (In Russ.)]. DOI: 15829/1560-4071-2015-12-14-19

 

УДК:616.2 DOI:10.20969/VSKM.2022.15(4).18-25

PDF download GENETIC PREDICTORS OF SARCOIDOSIS COURSE IN RUSSIAN COHORT

BALIONIS OLGA I., ORCID: 0000-0002-8251-4050, Research fellow of the Laboratory of Personalized Medicine, Pulmonology Scientific Research Institute under Federal Medical and Biological Agency of Russia, 115682, Russia, Moscow, Orekhovy blvd., 28, tel.: +7-906-265-15-59, e-mail: balionis@yandex.ru

NIKITIN ALEXEY G., ORCID: 0000-0001-9762-3383, PhD in Biology, Head of the Laboratory of Personalized Medicine, Pulmonology Scientific Research Institute under Federal Medical and Biological Agency of Russia, 115682, Russia, Moscow, Orekhovy blvd., 28, tel.: +7-495-395-63-93, e-mail: avialn@gmail.com

AVERYANOV ALEXANDER V., ORCID: 0000-0003-1031-6933, SPIN-код: 2229-7100, Corresponding member of the Russian Academy of Sciences, MD, Professor, Acting director of Pulmonology Scientific Research Institute under Federal Medical and Biological Agency of Russia, 115682, Russia, Moscow, Orekhovy blvd.,28, tel.: +7-495-395-63-93, e-mail: averyanovav@mail.ru

Abstract. Introduction. Sarcoidosis is a multisystem granulomatous disease of unknown etiology. Studies show that sarcoidosis might be the result of exposure to unidenti ed antigens in genetically susceptible individuals. Clinical manifestations of sarcoidosis are highly variable, and the disease course is unpredictable. The aim of the study was to identify the most signi cant genetic predictors related to disease course. Materials and methods. We performed a retrospective comparative study of patients with a favorable and unfavorable course of sarcoidosis. A total 100 patients (38 men and 62 women, mean age 50±13 years) with histologically con rmed sarcoidosis were included in the study. Results. 60 patients developed favorable course. 9 patients developed progressive disease course. 31 patients had relapses. We found out that carriage of the HLA-A*24:02, HLA-C*05:01, HLA-DRB1*12:01, HLA-DRB1*14:54, HLA-DQA1*01:04. HLA-DQB1*05:03, HLA-DPB1*105:01 alleles was associated with unfavorable prognosis. We also found that HLA-DQB1 NM_002123.5:c.703G>A p.Val235Ile, HLA-C NM_002117.6:c.895+37A>G, HLA-B NM_005514.8:c.620-40A>G, HLA-B NM_005514.8:c.344-10C>G, HLA DRB1-HLA-DQA1 n.32628264_32628265insAGA, CCR5 NM_000579.3:c.-448G>A genotypes are clinical negative prognostic factors. Conclusion. The detection of genetic predictors related to the sarcoidosis course may be helpful in personalized approach and appropriate treatment.

Keywords: sarcoidosis, genetic predictors, course of the disease.

For reference. Balionis OI, Nikitin AG, Averyanov AV. Genetic predictors of sarcoidosis course in Russian cohort. The Bulletin of contemporary clinical medicine. 2022;15(4):18-25, DOI: 10.20969/VSKM.2022.15(4).18-25.

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УДК: 614.2 DOI: 10.20969/VSKM.2022.26-32

PDF download ANALYSIS OF THE ONCOLOGICAL STATE AMONG THE LAW ENFORCEMENT AUTHORITIES OF THE OF SAKHA (YAKUTIA) IN THE 2019-2021

DOLINSKAYA ELVIRA A., ORCID ID: 0002-9437-5625; Head of Federal Unitary Enterprise Medical Unit of the Ministry of internal Affairs of Russia for the Sakha Respublic (Yakutia), colonel of the internal service, 677005, Yakutsk, Sverdlov str.,1/2 tel.8-4112-454-098 e-mail: elvi.67@mail.ru

ZAKHAROVA VICTORIA A., ORCID ID: 000-0001-7588-9498; Deputy Head of Federal Unitary Enterprise Medical Unit of the Ministry of Internal Affairs of Russia for the Sakha Respublic (Yakutia), lieutenant colonel of the internal service, 677005, Yakutsk, Sverdlov str.,1/2 tel. 8-4112-454-174, e-mail: zva_vvk@mail.ru

GUBKO ROMAN V., ORCID ID: 0000-0003-4770-821Х; Head of the Treatment and Prevention department, Medical Unit of the Ministry of Internal Affairs of Russia for the Sakha Respublic (Yakutia) lieutenant colonel of the internal service, 677005, Yakutsk, Sverdlov str.,1/2 tel. 8-4112-454-967, e-mail: gubkor@mail.ru

ZAKHAROVA INNA G., ORCID ID: 000-0001-5318-5895; Oncologist of the polyclinic Medical Unit of the Ministry of Internal Affairs of Russia for the Sakha Republic (Yakutia), 677005, Yakutsk, Sverdlov str.,1/2, e-mail: zakharovainnag@mail.ru

Abstract. Introduction. Cancer is the third most common disease type among all. It is one of the leading causes of death, disability and premature disability in the law enforcement system. Aim. The purpose of the study is identifying main forms of cancer, gender and age characteristics of oncological diseases, analysis of the oncological situation among law enforcement of cers to determine suitability for service. Material and methods. We performed a simple multivariate comparative analysis of law enforcement of cers' cancer morbidity data, individual clinical cases of patients according to hospital and military medical commission statistical reporting materials for 2019-2021. Results and discussion. All nosological forms of the diseases require specialized medical care. Cancer morbidity leads to long-term disability and, as a rule, to ineligibility for military service in the law enforcement system. Conclusion. Male patients of working age suffer from cancer more often. The age of oncopathology is quite wide and varies from 25 to 74 years among patients assigned to the Medical-Sanitary Unit. There is no direct connection of patients' oncopathology with the kind and type of the patient's activity. At timely detection the outcome of the disease for the patient in most cases remains favorable. The mortality from oncological pathology in 2019 - 2022 reaches 7.5 cases per 10,000 population. For the purpose of timely diagnosis and treatment it is necessary to develop the primary oncological branch in departments of outpatients' clinics, to conduct annual analysis of oncological morbidity, estimating the number of patients recognized ineligible for service in the internal affairs bodies.

Key words: cancer incidence, law enforcement of cers authorities, certi cation.

For reference: Dolinskaya EA, Zakharova VA, Gubko RV, Zakharova IG. Analysis of the oncological state among the law enforcement authorities of the Sakha (Yakutia) in the 2019-2021. 2022.15(4):26-32. DOI: 10.20969/VSKM. 2022.15(4).26-32.

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УДК:616.24-008.41 DOI:10.20969/VSKM.2022.15(4).33-43

PDF download CLINICAL EFFICACY OF RENGALIN COUGH-SUPPRESSANT THERAPY IN PATIENTS WITH NEW CORONAVIRUS INFECTION (COVID-19)

ZAITSEV ANDREY A., ORCID ID: 0000-0002-0934-7313, D. Med. Sci., Prof., Honored Doctor of the Russian Federation, Chief Pulmonologist of the Main Military Clinical Hospital named after Academician N.N. Burdenko, Russia, 105094, Moscow, Gospitalnaya sq., 3, tel. 8-916-588-32-12, e-mail: a-zaicev@yandex.ru

VIZEL ALEXANDER A., ORCID ID: 0000-0001-5028-5276, RSCI Author ID:195447; H-index (RSCI) = 24, D. Med. Sci., Prof., Honored Doctor of Tatarstan Republic, Head of the Department of phthisiopulmonology of Kazan State Medical University, 420012, Russia, Kazan, Butlerova St., 49; Head pulmonologist of Tatarstan Republic Ministry of Health, State Honoree of Tatarstan Republic in Science and Technics (Kazan, Russia), e-mail: lordara@mail.ru

SHAKIROVA GULNAZ R., ORCID ID: 0000-0002-2551-5671, Candidate of Medical Sciences, assistant professor, Phthisiopulmonology Department, Kazan State Medical University, 420012, Russia, Kazan, Butlerova St., 49; Pulmonologist of the Pulmonology Department of the Republican Clinical Hospital, Russia, 420000, Kazan, Orenburgsky Trakt St., 138, tel. 8-917-884-30-39, e-mail: adeleashakirova02@mail.ru

KULAGINA IRINA TS., ORCID ID: 0000-0002-5387-5244, Candidate of Medical Sciences, Head of the 20th Pulmonology Department of the Main Military Clinical Hospital named after Academician N.N. Burdenko, Russia, 105094, Moscow, Gospitalnaya sq., 3, e-mail: irina-kulagina@mail.ru

TERNOVSKAYA NINA A., ORCID ID: 0000-0003-3083-9635, Pulmonologist, Main Military Clinical Hospital named after Academician N.N. Burdenko, Russia, 105094, Moscow, Gospitalnaya sq l., 3, tel. 8-903-175-89-29, e-mail: nina.vishna@ yandex.ru

Abstract. Introduction. Cough is one of the main symptoms of new coronavirus infection. It is known that cough development in SARS-CoV-2 infection is caused by lung epithelial cells that do not result in marked exudative in ammation, therefore, anti-cough medications should be used to treat non-productive cough in COVID-19. At the same time there is not enough data about clinical effectiveness in relieving dry cough in patients with COVID-19, and that was the reason for conducting program about symptomatic effectiveness of Rengalin in real clinical practice. Aim. The goal is to study the clinical ef cacy and safety of Rengalin in comparison with standard symptomatic cough-suppressant therapy in COVID-19 patients. Material and methods. The program enrolled 100 patients, 50 of whom received the drug Rengalin and 50 patients formed the group 2, in which participants took other drugs as symptomatic cough-suppressant therapy. Cough severity was analyzed by "Cough severity scale" initially and in dynamics on the 4th, 8th day of the disease. Safety of therapy was assessed on the basis of vital signs of study participants, adverse events were recorded. Results and discussion. Use of Rengalin was accompanied by more expressed regression of cough in patients with COVID-19 in comparison with other anti-cough drugs. In the group of patients receiving Rengalin, severity of daytime cough on the 4th day of therapy made 0.6 ± 0.8 points, while in the 2nd group – 1.8 ± 1.1 points. Nocturnal cough on the 4th day of observation in the 1st group was 0.1 ± 0.3, while in the 2nd group it was 0.4 ± 0.5. In the group of patients who received Rengalin, the number of patients with absence of cough against the background of treatment was 43 (86%), while in group 2 - 27 (54%). On the 8th day of follow-up in the rst group all patients noted regression of cough, in group 2 - 38 (76%). Conclusion. The results obtained expand the understanding of the physiology of cough in patients with COVID-19 and allow the successful use of Rengalin in clinical practice.

Keywords: cough, new coronavirus infection (COVID-19), anti-cough medications.

For references: Zaitsev AA, Vizel AA, Shakirova GR, Kulagina ITs, Ternovskaya NA. Clinical ef cacy of Rengalin cough-suppressant therapy in patients with new coronavirus infection (COVID-19). The Bulletin of Contemporary Clinical Medicine. В2022.15 (4):33-43. DOI: 10.20969/VSKM.2022.15(4).33-43.

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УДК:616.441-002-035:615.252-06 DOI:10.20969/VSKM.2022.15(4).44-48

PDF download TREATMENT STRATEGY OF INTOLERANCE TO THYROID-STIMULATING DRUGS IN PATIENTS WITH GRAVES DISEASE

KRASIL'NIKOV DMITRY M., ORCID ID: 0000-0003-4973-4040; SCOPUS ID: 6508327107; D. Med. Sci., Professor, Head of the Department of Surgery of Kazan State Medical University, Chief specialist surgeon of Republican Clinical Hospital, Russia, 420012, Kazan, Butlerov Str., 49, tel. 8-843-231-21-35, e-mail: dmkras131@gmail.com

VALEEVA FARIDA V., ORCID ID: 0000-0001-6000-8002; D. Med. Sci., Professor, Head of the Endocrinology Department of Kazan State Medical University, Russia, 420012, Kazan, Butlerov Str., 49, tel. +7-917-255-55-79, e-mail: val_farida@mail.ru

BAREEVA LUIZA T., ORCID ID: 0000-0001-9007-4457; Head of the Department of Endocrinology of Republican Clinical Hospital, Assistant Professor of the Endocrinology Department of Kazan State Medical University, Russia, 420064, Kazan, Orenburgskiy Trakt, 138, tel. +7-917-913-53-32, e-mail: luizabar@yandex.ru

SHAKULO ANASTASIA V., ORCID ID: 0000-0003-2448-9579; 2nd year resident of the Endocrinology Department of Kazan State Medical University, Russia, 420012, Kazan, Butlerov Str., 49, tel. +7-927-684-75-06, e-mail: a.schakulo@mail.ru

MIRGASIMOVA DZHAUKHARIY M., ORCID ID: 0000-0002-8582-7212, C. Med. Sci, Assistant Professor of Department of Surgery of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, e-mail: d.mirgasimova@yandex.ru

ZAKHAROVA ANNA V., ORCID ID: 0000-0003-2264-1514, C. Med. Sci, Assistant Professor of Department of Surgery of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, e-mail: zahanna83@yandex.ru

Abstract. Introduction. The development of methods for the effective treatment of patients with Graves' disease (diffuse toxic goiter) with intolerance to thyroid-stimulating drugs remains one of the most dif cult problems in endocrinology and endocrine surgery. The issues of early diagnosis, tactics and volume of complex preoperative care and timing of the operation remain topical. Material and methods. From 2011 to 2020 in the departments of surgery of Republican Clinical Hospital 487 patients with Graves' disease were operated on. Among them were 69 (14.2%) patients with intolerance to thyroid-stimulating drugs, which were preoperatively prepared in the endocrinology department. Data analysis was carried out using the OriginPro 2015 program. During the statistical processing of the analyzed data, percentage indicators, average values, standard deviations, medians, values of the rst and third quartiles were calculated. The normality of distribution was assessed using the Shapiro-Wilk test, the signi cance of differences between groups was assessed using the Mann-Whitney U-test. Results and discussion. After multicomponent conservative management, all 69 patients were operated on. In the early postoperative period, 1 (1.45%) death was observed due to the development of pulmonary embolism. Conclusion. The choice of methods of adequate conservative therapy and the timely performing of radical surgical intervention promote good results of treatment of patients with Graves' disease with intolerance to thyroid-stimulating drugs.

Key words: Graves’ disease, thyrotoxicosis, side effects of thyrostatic treatment.

For reference: Krasil'nikov DM, Valeeva FV, Bareeva LT, Shakulo AV, Mirgasimova DM, Zakharova AV. Treatment strategy of intolerance to thyroid-stimulating drugs in patients with Graves’ disease. The Bulletin of Contemporary Clinical Medicine. 2022; 15(4):44-48. DOI: 10.20969/VSKM.2022.15(4).44-48.

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УДК:616.127-073:616.12-005.4 DOI:10.20969/VSKM.2022.15(4).49-53

PDF download RELATION BETWEEN STENOSIS AND CALCIFICATION OF CORONARY ARTERIES IN PATIENTS WITH CORONARY HEART DISEASE

FADEEV GRIGORIY A., ORCID ID: 0000-0002-0213-8631, Deputy Head, Clinical hospital of Ministry of Internal Affairs of Russian Federation in Republic of Tatarstan, Russia, 420059, Kazan, Orenburgskiy tract str., 132.

TSIBULKIN NIKOLAY A., ORCID ID: 0000-0002-1343-0478; C. Med. Sci., associate professor of the Department of cardiology, roentgen-endovascular and cardiovascular surgery of Kazan State Medical Academy – the branch of Russian Medical Academy of Postgraduate Education, Russia, 420012, Kazan, Butlerov str., 36.

ZAKIROVA ELVIRA B., ORCID ID: 0000-0002-4653-1734, C. Med. Sci., Deputy Head, Municipal clinical hospital No7, 420103, Kazan, Chuikov str., 54. e-mail: frolova.67@mail.ru

FAIZULLINA GULNARA G., ORCID ID: 0000-0002-3785-2528, Head of Department of ultrasound diagnostic, Clinical hospital of Ministry of Internal Affairs of Russian Federation in Republic of Tatarstan, Russia, 420059, Kazan, Orenburgskiy tract str., 132.

GAYNUTDINOVA LEYSAN I., ORCID ID: 0000-0002-5859-8776, C. Med. Sci., Head of the Department of High-Tech Medical Care, Municipal clinical hospital No7, 420103, Kazan, Chuikov str., 54. e-mail: orgmetod.rkb3@mail.ru

Abstract. Introduction. Coronary heart disease is one of frequent nosological forms in clinical practice. It is based on atherosclerosis of coronary arteries, main element of which are atherosclerotic plaques. Proliferation of plaques in lumen of vessel leads to its stenosis. Usually coronary atherosclerosis has progressive course, which manifests itself in change in internal composition of plaque. Progression of atherosclerosis is also re ected in increase in degree of calci cation of coronary arteries, which can be characterized by degree of calci cation. Calci cation index is indicator of prevalence and severity of atherosclerotic lesions of coronary bed. Aim. To compare indicators characterizing severity of coronary artery stenosis and calci cation according to coronary computed tomography angiography in patients with coronary heart disease. Material and methods. Study included 56 patients. Indicators of calci cation of coronary arteries (calcium index of left descending artery, left circum ex artery, right coronary artery, Agatson index), as well as degree of coronary artery stenosis were used. Results and discussion. Degree of calci cation was highest in left descending artery, lowest calci cation in left circum ex artery, and in right coronary artery calcium index had intermediate value. Regression analysis was used to determine relation of severity of calci cation of coronary arteries and degree of their stenosis. Values of these indicators showed signi cant dependence. In proximal segments of all arteries this dependence is linear. In distal segments of all arteries dependence of stenosis and calci cation had form of non-linear regression. Conclusion. Coronary arteries have different severity of calci cation: it is most pronounced in left descending artery. Degree of stenosis and calci cation demonstrate different variants of relationship depending on artery and segments.

Key words: atherosclerosis, coronary computed tomography angiography, calci cation.

For references: Fadeev GA, Tsybulkin NA, Zakirova EB, Faizullina GG, Gaynutdinova LI. Relation between stenosis and calci cation of coronary arteries in patients with coronary heart disease. The Bulletin of Contemporary Clinical Medicine. 2022; 15(4):49-53. DOI: 10.20969/VSKM.2022.15(4).49-53.

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УДК:616.12-008.46:616.153.96 DOI:10.20969/VSKM.2022.15(4).54-59

PDF download IS IT NECESSARY TO DETERMINE HIGHLY SENSITIVE C-REACTIVE PROTEIN IN PATIENTS WITH CHRONIC HEART FAILURE: CLINICAL AND PROGNOSTIC ASPECTS

KHAZOVA ELENA V., ORCID ID: 0000-0001-8050-2892; Scopus Author ID: 57205153574, Resercher ID O-2336-2016, RSCI Author ID 639552; C. Med. Sci, Associate professor, Department of Internal Medicine named after Professor SS. Zimnitsky, Kazan State Medical University, 420012, Russia, Kazan, Butlerov str., 49, e-mail: hazova_elena@mail.ru (author for correspondence)

BULASHOVA OLGA V., ORCID ID: 0000-0002-7228-5848; Scopus Author ID: 6507198087, RSCI Author ID 46110692, D. Med. Sci, Professor, Department of Internal Medicine named after Professor SS. Zimnitsky, Kazan State Medical University, 420012, Russia, Kazan, Butlerov str. 49, e-mail: boulashova@yandex.ru

AMIROV NAIL B., ORCID ID: 0000-0003-0009-9103; Scopus Author ID: 7005357664, Resercher ID E-3177-2016, RSCI Author ID 259320, D. Med. Sci, Professor, Department of Outpatient Medicine and General medical practice, Kazan State Medical University, 420012 Russia, Kazan, Butlerov str., 49, Deputy Chief of Science, The Medical and Healthcare Unit of the Ministry of Internal Affairs of the Russian Federation in the Republic of Tatarstan, e-mail: namirov@mail.ru

Abstract. Introduction. High-sensitivity C-reactive protein is an established marker of systemic in ammation and is associated with the severity and outcomes of chronic heart failure. Aim. The aim of the work is to evaluate the clinical characteristics and long-term 5-year prognosis in patients with chronic heart failure of ischemic origin in relation to the level of high-sensitivity C-reactive protein. Material and methods. The study included 296 patients of both sexes with stable chronic heart failure of ischemic origin. We analyzed the clinical characteristics and the risk of events within 5 years in patients with chronic heart failure with different levels of high-sensitivity C-reactive protein. Results and discussion. The median concentration of high-sensitivity C-reactive protein in patients with chronic heart failure of ischemic origin was 3.21 [1.48; 7.59] mg/l. In 52.1% of patients with chronic heart failure, the level of high-sensitivity C-reactive protein exceeded 3 mg/l, in 31% of patients, high-sensitivity C-reactive protein was in the range of 1-3 mg/l, in 16.9% of patients, the level of high-sensitivity C-reactive protein did not exceed 1 mg/l. Patients with chronic heart failure who had previously had a cerebral stroke had higher levels of high-sensitivity C-reactive protein in patients with chronic heart failure only (5.88 [2.69; 8.94] mg/l and 3.1 [1.31; 7.15] mg/l, p=0.018). Correlations were found between high-sensitivity C-reactive protein values and body mass index (rs=0.181, p=0.005), quality of life in patients with chronic heart failure (rs=0.159, p=0.019), glucose levels (rs=0.143, p=0.028), creatinine (rs=0.153, p=0.019), uric acid (rs= 0.188, p=0.008), hemoglobin (rs= - 0.148, p=0.022). According to the ROC analysis, the value of hs CRP 3.59 mg/l can be considered as a marker of death in patients with chronic heart failure (sensitivity - 61.8%, speci city - 56.7%). An analysis of the outcomes of patients with chronic heart failure over 5 years demonstrates a greater risk of death in patients with chronic heart failure with high-sensitivity C-reactive protein more than 3 mg/l, compared with patients with high-sensitivity C-reactive protein less than 3 mg/l (OR = 2.86, CI 1.164-7.038) and with patients with levels less than 1 mg/l was (OR=0.18, CI 0.05-0.74).

Key words: chronic heart failure, high-sensitivity C-reactive protein, prognosis.

For reference: Hazova EV, Bulashova OV, Amirov NB. Is it necessary to determine highly sensitive C-reactive protein in patients with chronic heart failure: clinical and prognostic aspects. Bulletin of contemporary clinical medicine. 2022; 15.(4): 54-59. DOI: 10.20969 / VSKM.2022.15 (4).54-59.

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17. Xu R, Yin X, Xu W, et al. Assessment of carotid plaque neovascularization by contrast-enhanced ultrasound and high sensitivity C-reactive protein test in patients with acute cerebral infarction: a comparative study. Neurol Sci. 2016; 37(7):1107-1112. DOI: 10.1007/s10072-016-2557-2

18. Kazemi-Saleh D, Koosha P, Sadeghi M, et al. Predictive role of adiponectin and high-sensitivity C-reactive protein for prediction of cardiovascular event in an Iranian cohort Study: The Isfahan Cohort Study. ARYA Atheroscler. 2016; 12(3): 132-137.

 

УДК:616.24 DOI:10.20969/VSKM.2022.15(4).60-64

PDF download BLOOD EOSINOPHIL COUNT AND COPD EXACEBRATIONS: IS IT ALL STRAIGHTFORWARD

KHAMITOV RUSTEM F., ORCID ID: 0000-0001-8821-0421, D. Med. Sci., professor, Head of Department Internal Medicine, Kazan State Medical University, 420012, Russia, Kazan, Butlerova Str., 49, +7-843-236-06-52, e-mail: rhamitov@mail.ru

ZINNATULLINA AYGUL R., ORCID ID: 0000-0003-1974-1071, Assistant Professor of Department Internal Medicine, Kazan State Medical University, 420012, Russia, Kazan, Butlerova Str., 49, tel.: +7-905-039-35-57, e-mail: aigoul-zinnatullina. rust@mail.ru

MIHOPAROVA OLGA YU., ORCID ID: 0000-0002-5592-8450, Head functional diagnostics room of the Clinical Hospital of the Medical and Sanitary Department of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, Russia, 420059, Kazan, Orenburgsky Trakt, 132, e-mail: olga-mihoparova@rambler.ru

Abstract. Introduction. Eosinophils’ role in frequent exacerbations of chronic obstructive pulmonary disease continues to be discussed in the respiratory community, as the place of inhaled steroids in chronic obstructive pulmonary disease’s therapy.Аim. Тo identify the dependence of the frequency of exacerbations on the level of blood eosinophils and the appointment of inhaled steroids. Material and methods. Retrospective analysis of 424 medical records of inpatients for 2015-2018 years was made. Statistical data processing was carried out using the SPSS Statistics program, the data are presented as М±σ and as frequency. Pearson's chi-square method and Student's t-test were used. Differences were considered signi cant at p<0.05. Results and discussion. During this period, there were 276 cases of single hospitalizations (the control group) and 148 cases of repeated (the main group). The average level of eosinophils during hospitalization in the main group was 118 [0; 234] cells/μl, (in the control - 128 [0; 280]) (p˃0.05). In the main group the level of blood eosinophils <100 cells/μl had 45.2% of patients, 100-300 cells/μl - 41.2%, ˃300 cells/μl - 13.6%. In the control - 40.6% of patients had <100 eosinophils/μl, 35.9% - 100-300 cells/μl, 23.5% - ˃300. The proportion of patients with hypereosinophilia during hospitalization in the main group was 1.7 times less. Patients of the main group who received inhaled steroids on an outpatient basis, on average, had 91 [0; 224] eosinophils/μl, non-receiving – 128 [0; 235] (p<0.05) (respectively in the control group, 133 [0; 354] and 128 [0; 280] (p<0.05)). At discharge, the average level of eosinophils in the main group was 136 [0; 224] cells/μl, in the control - 107 [0; 288] (p˃0.05). Conclusion. 1. Patients with repeated hospitalizations generally tended to have a lower level of blood eosinophils with a higher frequency of outpatient use of inhaled steroids. 2. In the main group, extremely severe obstructive disorders were more common, which was accompanied by a higher level of blood eosinophils in this category of patients compared with the control group.

Key words: eosinophils, COPD exacerbations, chronic obstructive pulmonary disease.

For references: Khamitov RF, Zinnatullina AR, Mihoparova OY. Blood eosinophil count and COPD exacebrations: is it all straightforward. The Bulletin of Contemporary Clinical Medicine. 2022; 15 (4):60-64 DOI: 10.20969/VSKM.2022. 15(4).60-64.

References

1. Трофименко И.Н., Черняк Б.А. Клиническая характеристика эозинофильного фенотипа хронической обструктивной болезни легких // Фарматека для практикующих врачей. – 2017. – No 4. – С.10-15. https:// pharmateca.ru/ru/archive/article/34667 [Дата обращения: 2 мая 2022]. [Tro menko IN, Chernyak BA. Klinicheskaya harakteristika eozino l’nogo fenotipa hronicheskoj obstruktivnoj bolezni legkih [Clinical characteristics of the eosinophilic phenotype of chronic obstructive pulmonary disease]. Farmateka dlya praktikuyushchih vrachej [Pharmacy for practitioners]. 2017; 4: 10-15. https://pharmateca.ru/ru/archive/ article/34667 [Accessed: Мay 5, 2022] (in Russ)].

2. David B, Bafadhel M, Koenderman L, De Soyza A. Eosinophilic in ammation in COPD: from an in ammatory marker to a treatable trait. J Thorax. 2021; 76 (2): 188-195. DOI: 10.1136/thoraxjnl-2020-215167

3. Global Initiative for Chronic Obstructive Lung Disease (GOLD) guideline: Global Strategy for the Diagnosis, management and Prevention of Chronic Obstructive Pulmonary Disease [Internet] 2021. [Аccessed on 2022 Jun 1]. http://www.goldcopd.com

4. Российское респираторное общество. Хроническая обструктивная болезнь легких: Федеральные клинические рекомендации. 2021. [Rossijskoe respiratornoe obshhestvo. Нronicheskaya obstruktivnaya bolezn` legkih: Federal`ny`e klinicheskie rekomendacii [Russian Respiratory Society.Chronic Obstructive Pulmonary Disease: Federal Clinical Guidelines.]. 2021. https://spulmo.ru/obrazovatelnye-resursy/federalnye- klinicheskie-rekomendatsii/ [Дата обращения: 5 мая 2022]. (in Russ)].

5. Айсанов З.Р., Авдеев С.Н., Архипов В.В. и др. Национальные клинические рекомендации по диагностике и лечению ХОБЛ: алгоритм принятия клинических решений // Пульмонология. – 2017. – Т. 27, вып. 1. – С.13-20. [Aisanov ZR, Avdeev SN, Arkhipov VV, et. al. Nacional’nye klinicheskie rekomendacii po diagnostike i lecheniyu HOBL: algoritm prinyatiya klinicheskih reshenij [National clinical guidelines on diagnosis and treatment of chronic obstructive pulmonary disease: a clinical decision-making algorithm]. Pul’monologiya [Russian Pulmonology]. 2017; 27 (1): 13-20. (In Russ.)]. DOI:10.18093/0869-0189-2017-27-1-13-20

6. Авдеев С.Н., Трушенко Н.В., Мержоева З.М. и др. Эозинофильное воспаление при хронической обструктивной болезни легких // Терапевтический архив. – 2019. – Т. 91, вып. 10. – С.144-152. [Avdeev SN, Trushenko NV, Merzhoeva ZM, et al. Eozino l’noe vospalenie pri hronicheskoj obstruktivnoj bolezni legkih [Eosinophilic in ammation in chronic obstructive pulmonary disease]. Terapevticheskij arhiv [Therapeutic Archive]. 2019; 91 (10): 144–152. (In Russ.)]. DOI: 10.26442/00403660.20 19.10.000426

7. Simon Couillard, Pierre Larivée, Josiane Courteau, Alain Vanasse. Eosinophils in COPD Exacerbations Are Associated With Increased Readmissions. J Chest. 2017; 151 (2): 366-373. DOI: 10.1016/j.chest.2016.10.003

8. Hartl S, Breyer M-K, Burghuber OC, et al. Blood eosinophil count in the general population: typical values and potential confounders. Eur Respir J 2020; 55: 1901874. DOI:10.1183/13993003.01874-2019

9. Weir M, Zhao H, Han MK, Kanner R, Pirozzi CS, Scholand MB, et al. Eosinophils in chronic obstructive pulmonary disease, the SPIROMICS cohort. Am J Resp ir Crit Care Med. 2014; 189: A5902. DOI: 10.1016/S2213-2600(17)30432-0

10. Со А.К., Авдеев С.Н., Нуралиева Г.С. и др. Предикторы неблагоприятного исхода при обострении хронической обструктивной болезни легких. Пульмонология. – 2018. – Т. 28, вып 4. – С.446-452. [So AK, Avdeev SN, Nuralieva GS i dr. Prediktory neblagopriyatnogo iskhoda pri obostrenii hronicheskoj obstruktivnoj bolezni legkih. [Predictors of poor outcome in exacerbation of chronic obstructive pulmonary disease]. Pul’monologiya [Рulmonology]. 2018; 28(4): 446-452. (In Russ.)]. DOI: 10.18093/0869-0189-2018-28-4-446-452

11. Овчаренко С.И. Ингаляционные глюкокортикостероиды в терапии больных хронической обструктивной болезнью легких: быть или не быть?! // Практическая пульмонология. – 2016; – No 1. – С.16-22. [Ovcharenko SI. Ingalyacionnye glyukokortikosteroidy v terapii bol’nyh hronicheskoj obstruktivnoj bolezn’yu legkih: byt’ ili ne byt’?! [Inhaled corticosteroids in the treatment of patients with chronic obstructive pulmonary disease: to be or not to be?!]. Prakticheskaya pul’monologiya [Practical pulmonology]. 2016; 1: 16-22. http://www.atmosphere-ph. ru/modules/Magazines/articles/pulmo/PP_1_2016_16. pdf [Дата обращения: 5 мая 2022]. (in Russ)].

 

REVIEWS

УДК:340.692:725.1.012.1 DOI:10.20969/VSKM.2022.15(4).65-69

PDF download MAIN ASPECTS OF ENGINEERING AND TECHNICAL DESIGN OF BUILDINGS AND ISSUES OF LOGISTICS AND TECHNICAL SUPPORT OF THE BUREAU OF FORENSIC MEDICAL EXAMINATION AND PATHOLOGOANATOMICAL DEPARTMENTS FROM THE POINT OF VIEW OF THE ORGANIZATION OF SANITARY-HYGIENIC AND ANTI-EPIDEMIC MEASURES

VASILIEV DENIS E., ORCID ID: 0000-0002-6205-3760, Candidate of Medical Sciences, Department of Preventive Medicine, Kazan (Volga Region) Federal University — Institute of Fundamental Medicine and Biology, Kazan, Russia; 420012, Kazan, Karl Marx str., 76, tel. 8(843) 236-78-92, e-mail: medbiol@kpfu.ru

Abstract. Introduction. The review article discusses the issues of modern logistics in the production of forensic medical examinations from the infectious safety of personnel point of view. Forensic medical examination institutions are special types of health care institutions. Special requirements are imposed on the design of buildings and the logistics of such institutions. Aim.The purpose of the study is to analyze scienti c information on the planning decisions of buildings for forensic purposes and the material and technical equipment of the forensic medical examination in terms of infectious safety of personnel. Material and methods. When preparing a literature review, the literature search method was used in the PubMed, eLibrary.ru, Google Scholar databases for the period 2005–2021. The analysis included literature reviews, meta-analyses, and clinical studies. Results and discussion. The studies present organizational and technological solutions for the design of buildings and the logistics of institutions of forensic medical examination. Attention is drawn to compliance with sanitary standards and requirements for premises, equipment in accordance with standards in order to create safe working conditions for forensic doctors, which ultimately allows to signi cantly improve the quality of forensic medical examination. Conclusion. Researchers have recognized that at present, the infectious safety of employees of forensic institutions is very important. The Bureau of Forensic Medical Examination and pathology departments need to be improved. This improvement should be based on modern building design and sanitary and hygienic logistical support, so building and improving the logistical capacity of these institutions is necessary and remains a major challenge to be addressed.

Key words: forensic examination, logistics, building design, infectious safety.

For reference: Vasiliev DE. Main aspects of engineering and technical design of buildings and issues of logistics and technical support of the bureau of forensic medical examination and pathologoanatomical departments from the point of view of the organization of sanitary-hygienic and anti-epidemic measures. The Bulletin of Contemporary Clinical Medicine. 2022;15(4):65-69. DOI: 10.20969/VSKM.2022.15(4).65-69.

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6. Бектасова М.В., Шепарев А.А., Ластова Е.В. Возможное влияние архитектурно-планировочных решений лечебно-профилактических учреждений на заболеваемость медицинского персонала на примере города Владивостока // Бюллетень ВСНЦ СО РАМН. – 2006. – No 5. – С. 262-264. [Bektasova MV, SHeparev AA, Lastova EV. Vozmozhnoe vliyanie arhitekturno-planirovochnyh reshenij lechebno-pro lakticheskih uchrezhdenij na zabolevaemost’ medicinskogo personala na primere goroda Vladivostoka [Possible in uence of architectural and planning decisions of medical institutions on the incidence of medical personnel on the example of the city of Vladivostok]. Byulleten’ VSNC SO RAMN [Bulletin of VSNC SO RAMS]. 2006; 5: 262-264. (In Russ.)].

7. Ильина О.А., Шулаев А.В., Тимерзянов М.И. К вопросу оценки биологических факторов риска в практике врача-судебно-медицинского эксперта // Медицинский альманах. – 2018. – No 4(55). – С. 149-151. [Il’ina OA, SHulaev AV, Timerzyanov MI. K voprosu ocenki biologicheskih faktorov riska v praktike vracha-sudebno-medicinskogo eksperta [On the issue of assessing biological risk factors in the practice of a forensic medical expert]. Medicinskij al’manah [Medical Almanac]. 2018; 4: 149-151. (In Russ.)]. DOI: 10.21145/2499-9954-2018-4-149-151

8. Teresiński G, Jurek T. Recommendations of the Polish society of forensic medicine and criminology and National consultant for forensic medicine with regard to performing forensic post-mortem examinations in case of con rmed COVID-19 disease and suspected SARS CoV-2 infections. Arch Med Sadowej Kryminol. 2019; 69: 147-157. DOI: 10.5114/amsik

9. Baj J, Ciesielka M, Buszewicz G, et al. Covid-19 in the autopsy room-requirements, safety, recommendations and pathological ndings. Forensic. Sci. Med. Pathol. 2021; 17: 101–113. DOI: 10.1007/s12024-020-00341-

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11. Dijkhuizen LGM, Gelderman HT, Duijst WLJM. The safe handling of a corpse (suspected) with COVID-19. J. Forensic. Leg. Med. 2020; 73:101999. DOI: 10.1016/j.jm.2020.101999

12. Francesco MF, Scappaticci L, Schilling S, et al. A 2009 cross-sectional survey of procedures for post mortem management of highly infectious disease patients in 48 isolation facilities in 16 countries: data from EuroNHID. Infection. 2016; 44 (1): 57-64. DOI: 10.1007/s15010-015-0831-5

13. Alfsen GC, Gulczyński J, Kholová I, et al. Code of practice for medical autopsies: a minimum standard position paper for pathology departments performing medical (hospital) autopsies in adults. Virchows. Arch. 2021; 10: 1-9. DOI: 10.1007/s00428-021-03242-y

14. Всемирная организация здравоохранения (ВОЗ). Рекомендованные ВОЗ рецептуры антисептиков для руководителей: руководство по организации производства на местах [Vsemirnaya organizaciya zdravoohraneniya (VOZ). Rekomendovannye VOZ receptury antiseptikov dlya rukovoditelej: rukovodstvo po organizacii proizvodstva na mestah [World Health Organization (WHO). WHO-recommended antiseptic formulations for executives: a guide to local production]. https://www.who.int/gpsc/5may/ tools/guide_local_production_ru.pdf?ua=1

15. Юсупова И.Р. Меры профилактики врача-патологоанатома при проведении секционного исследования трупа инфицированного ВИЧ // Вестник совета молодых учёных и специалистов Челябинской области. – 2016. – Т. 2, No 3. – С. 86-88. [YUsupova IR. Mery pro laktiki vracha-patologoanatoma pri provedenii sekcionnogo issledovaniya trupa in cirovannogo VICH [Measures of prevention by a pathologist during a sectional examination of a corpse infected with HIV]. Vestnik soveta molodyh uchyonyh i specialistov CHelyabinskoj oblasti [Bulletin of the Council of Young Scientists and Specialists of the Chelyabinsk Region]. 2016; 2 (3): 86-88. (In Russ.)].

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17. Methods of airborne room disinfection by automated process. Determination of bactericidal, mycobactericidal, sporicidal, fungicidal, yeasticidal, virucidal and phagocidal activities Polish committee for standardization chemical disinfectants and antiseptics. https://shop.bsigroup.com/ ProductDetail?pid=000000000030374486

18. Kovach SM. Research: Ensuring cavitation in a medical device ultrasonic cleaner. Biomed. Instrum. Technol. 2019; 53 (4): 280-285. DOI: 10.2345/0899-8205-53.4.280

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21. Кильдюшов Е.М., Тимерзянов М.И. Возможные пути обеспечения инфекционной безопасности в работе бюро судебно-медицинской экспертизы // Организация судебно-медицинской службы России на современном этапе: задачи, пути, решения, результаты. Труды Всероссийской научно-практической конференции. – Воронеж, 2016. – С. 476-481. [Kil’dyushov EM, Timerzyanov MI. Vozmozhnye puti obespecheniya infekcionnoj bezopasnosti v rabote byuro sudebno-medicinskoj ekspertizy [Possible ways of ensuring infectious safety in the work of the bureau of forensic medical examination]. Organizaciya sudebno-medicinskoj sluzhby Rossii na sovremennom etape: zadachi, puti, resheniya, rezul’taty. Trudy Vserossijskoj nauchno-prakticheskoj konferencii [Organization of the forensic medical service in Russia at the present stage: tasks, ways, solutions, results. Proceedings of the All-Russian Scienti c and Practical Conference]. Voronezh. 2016: 476-481. (In Russ.)]. DOI: 10.17116/sudmed201659564-68

 

УДК:616.24-002.91-06-002 DOI:10.20969/VSKM.2022.15(4).70-79

PDF download COVID-19 AND SARCOIDOSIS: COMORBIDITY, CONSEQUENCES, CAUSE-AND-EFFECT RELATIONSHIPS. A LITERATURE REVIEW

VIZEL ALEXANDER A., ORCID ID: 0000-0001-5028-5276; SPIN code: 5918-5465; Author ID: 195447, D. Med. Sci., professor, Head. Phthisiopulmonology Department of the Kazan State Medical University, 420012, Russia, Kazan, Butlerov str., 49, tel.: +7-987-296-25-99, e-mail: lordara@inbox.ru

VIZEL IRINA YU., ORCID ID: 0000-0002-8855-8177; SPIN code: 6000-3813, Author ID: 246946, D. Med. Sci., professor of the Russian Academy of Natural Sciences, Associate Professor of the Department of Phthisiopulmonology of the Kazan State Medical University, 420012,Russia, Kazan, Butlerov str., 49; tel.: +7-917-903-91-13, e-mail: tatpulmo@mail.ru

SHAKIROVA GULNAZ R., ORCID ID: 0000-0002-2551-5671; C. Med. Sci., assistant of Phthisiopulmonology Department of the Kazan State Medical University, 420012, Russia, Kazan, Butlerov str., 49, tel.: +7-917-884-30-39, e-mail: adeleashakirova@mail.ru

AMIROV NAIL B., ORCID ID: 0000-0003-0009-9103; SCOPUS Authоr ID: 7005357664; D. Med. Sci., Professor of the Department of outpatient medicine and general medical practice of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel.: +7-843-291-26-76, e-mail: namirov@mail.ru

Abstract. Introduction. Sarcoidosis and COVID-9 are diseases in which the response of the human immune system plays a signi cant role in the pathogenesis. Descriptions of cases of a combination of these diseases and the development of a granulomatous reaction in those who have undergone COVID-19 make it relevant to study these two diseases. Aim. The aim of the work was to analyze publications available in electronic libraries that included information about patients with sarcoidosis during the COVID-19 pandemic. Material and methods. A search was conducted in the domestic electronic library E-library, as well as PubMed / Medline, Web of Science and Google Scholar for two keywords “COVID-19” and “sarcoidosis”. 47 papers were selected and analyzed. Results and discussion. An analysis of basic research indicates the possibility of mutual influence of these diseases at the level of cytokines, enzymes and immune system reactions. Moreover, 33 common differentially expressed genes have been identi ed. When diagnosing sarcoidosis and COVID-19 using computed tomography, similar patterns were noted, with the exception of focal dissemination, which is characteristic only for sarcoidosis. Hopes are placed on software capable of self-learning based on veri ed cases. The incidence of COVID-19 in patients with sarcoidosis ranged from 0.34% to 4%. The course of COVID-19 in these patients was not severe or threatening, with the exception of elderly patients with initially severe sarcoidosis with ventilatory insuf ciency and comorbidities. In the post-covid period, cases of sarcoidosis or sarcoid reactions that developed after recovery have been described. Similar reactions have been described after vaccination against coronavirus infection. These facts also testify in favor of the generality of immunological and metabolic changes that determine the mutual in uence of diseases. Conclusion. The combination of sarcoidosis and COVID-19 occurred during the pandemic, but in most cases did not lead to mutual aggravation of the conditions. The development of granulomatous processes after COVID-19 and vaccination against this disease makes further fundamental research aimed at nding common links in the pathogenesis of these diseases relevant.

Key words: sarcoidosis, COVID-19, diagnosis, treatment, vaccination.

For reference: COVID-19 and sarcoidosis: comorbidity, consequences, cause-and-effect relationships. Literature review. Vizel AA, Vizel IYu, Shakirova GR, Amirov NB. The Bulletin of contemporary clinical medicine. 2022; 15(4):70-79. DOI: 10.20969/ VSKM.2022.15(4).70-79.

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УДК:613.6.027+616.85 DOI: 10.20969/VSKM.2022.15(4).80-85

PDF download CONTRIBUTION OF OCCUPATIONAL MEDICINE TO THE PREVENTION OF HARMFUL ALCOHOL USE

KUZMINA SVETLANA V., ORCID ID: 0000-0002-7330-1213; Doctor of Medical Sciences, Associate Professor of the Department psychiatry and medical psychology of the Kazan State Medical University, 420012, Russia, Kazan, Butlerov str., 49, tel.: +7 987400-65-05, e-mail: skouzmina21@list.ru

GARIPOVA RAILYA V., ORCID ID: 0000-0001-8986-8030; Doctor of Medical Sciences, Professor of the Department hygiene, occupational medicine of the Kazan State Medical University, 420012, Russia, Kazan, Butlerov str., 49, Professor of the Department preventive medicine of the Kazan (Volga Region) Federal University, 420008, Russia, Kazan, Kremlin str., 18, tel.: +7 917255-38-44, e-mail: railyagaripova@mail.ru

SULTANOVA DILYA R., ORCID ID: 0000-0001-7410; Deputy Head of Clinical hospital of Medical Unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, 420059, Russia, Kazan, Orenburgskiy tract str., 132, tel.: +7952030-98-13, e-mail: dsultanova101@gmail.com

Abstract. Introduction. The European Mental Health Action Plan, approved by the World Health Organization in 2013, outlines the objectives of the strategy for reducing harmful alcohol use, including reducing harmful effects and reducing alcohol-associated mortality. The implementation of the set goals will make it possible to improve the health, quality of life and increase the working capacity of population. Аim. Тo assess the involvement of occupational medicine in the prevention of harmful alcohol use. Material and methods. Аnalytical review of the current scienti c databases for the period from 2004 to 2022 was carried out. Results and discussion. Тhe analysis of 32 data’s, including reviews and current legislative acts, which re ect the provisions on the state of mental health in connection with the occupational environment, the job-place conditions and the in uence of harmful working factors on the health of workers, including data related to the harmful use of alcohol. Conclusion. Тo identify such a behavioral risk factor as «harmful alcohol consumption» (or consumption with harmful consequences), encoded by F10.1 in the International Classi cation of Diseases of the 10th revision, it is necessary to include in the list of mandatory, if a psychiatrist detects suspicion of alcohol abuse during a periodic medical examination, studies on the concentration of carbohydrate de cient transferrin - a marker of alcohol abuse.

Keywords: The harmful effects of alcohol, mental health; adverse working conditions; mental maladjustment; employee health.

For reference: Kuzmina SV, Garipova RV, Sultanova DR. Contribution of occupational medicine to the prevention of harmful alcohol use. The Bulletin of Contemporary Clinical Medicine. 2022; 15(4):80-85. DOI: 10.20969/VSKM.2022.15(4).80-85.

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УДК:616-089.165 DOI:10.20969/VSKM.2022.15(4).86-93

PDF download ON THE POSSIBILITY OF USE OF ADHESIVE SURGICAL DRAPES

MOROZOV ARTEM M., ORCID ID: 0000-0003-4213-5379; Surgeon, Polyclinic No. 1, City Clinical Hospital No. 7, Russia, 170036, Tver, St. Petersburg str., 76/3; C. Med. Sci., Associate Professor of the Department of General Surgery, Tver State Medical University, Russia, 170100, Tver, Sovetskaya str., 4

SERGEYEV ALEKSEY N., ORCID ID: 0000-0002-9657-8063; Surgeon, Polyclinic No. 1, City Clinical Hospital No. 7, Russia, 170036, Tver, St. Petersburg str., 76/3; D. Med. Sci., Associate Professor, Head of the Department of General Surgery, Tver State Medical University, Russia, 170100, Tver, Sovetskaya str., 4

MOROZOVA ANASTASIA D., ORCID ID: 0000-0001-9566-3621; Otorhinolaryngologist, Polyclinic No. 1, City Clinical Hospital No. 7, Russia, 170036, Tver, st. sh. Petersburg, 76/3

RACHEK ANDREY M., ORCID ID: 0000-0002-1749-492X; Surgeon, Head of the Surgical department, Solnechnogorsk Regional Hospital, Russia, 141508, Solnechnogorsk

KURKOVA VERONIKA V., ORCID ID: 0000-0002-0612-3920; 5th year student of the Faculty of General Medicine, Tver State Medical University, Russia, 170100, Tver, Sovetskaya str., 4

SEMENOVA SOFYA M., ORCID ID: 0000-0002-0799-041X; 5th year student of the Faculty of General Medicine, Tver State Medical University, Russia, 170100, Tver, Sovetskaya str., 4

BELYAK MARIA A., ORCID ID: 0000-0001-6125-7676; student 4 course of the Faculty of General Medicine, Tver State Medical University, Russia, 170100, Tver, Sovetskaya str., 4, belyakmariah@yandex.ru

NEVOSTRUEVA ANNA A., ORCID ID: 0000-0003-1340-4496; 5th year student of the General Medicine Faculty, Tver State Medical University, Russia, 170100, Tver, Sovetskaya str., 4

Abstract. Introduction. Infection of the surgical eld is a common cause of purulent-septic complications. Various studies show that the majority of cases of infection of the surgical eld occurs by patients' own micro ora directly during surgical manipulations, as well as in the early postoperative period. Aim. The aim of the study is to study the types and possibilities of using self-adhesive surgical lms. Material and methods. In the course of this study, the analysis of literature sources containing information on the use of self-adhesive surgical lms was carried out. Results and discussion. A modern alternative to the treatment of the surgical field with antiseptic solutions is the use of surgical lms. Self-adhesive surgical lms prevent the spread of microorganisms from the skin surrounding the surgical eld directly into the wound. They may be impregnated with an antiseptic or not have it in their composition. The lms provide effective isolation of the surgical eld, for this reason, the possibility of exogenous infection is excluded. The use of lms implies the rejection of surgical underwear, which, with the standard preparation of the surgical eld, is applied to the area of the intended incision. Conclusion. Currently, there is no unambiguous data on the effectiveness of the use of self-adhesive surgical lms. A number of researchers note not only a signi cant decrease in the infection of the surgical intervention area when using surgical lms, but also a reduction in the cost of medical care for patients, other works, on the contrary, either do not note noticeable differences between the use of lms and surgical interventions without these antiseptic drugs or show an increase in the contamination of the surgical eld when using surgical lms.

Key words: asepsis, antiseptics, surgical eld, self-adhesive surgical lms, povidone-iodine, chlorhexidine, thermal gel.

For reference: Morozov AM, Sergeev AN, Morozova AD at al. On the possibility of use of adhesive surgical drapes. BulletinВof Contemporary Clinical Medicine. 2022; 15(4):86-93. DOI: 10.20969/VKSM.2022.15(4).86-93.

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УДК:616.62-008.87 DOI:10.20969/VSKM.2022.15(4).94-101

PDF download LOWER URINARY TRACT INFECTIONS (CYSTITIS, BACTERIURIA) IN OUTPATIENT PRACTICE: CHANGING THE STRATEGY AND TACTICS OF EMPIRICAL ANTIMICROBIAL THERAPY (NEW CLINICAL RECOMMENDATIONS)

SIGITOVA OLGA N., ORCID ID: 0000-0001-8983-245; Web of Science Researcher ID AAV-1365-2021; Scopus Author ID 527686; D.Med. Sci., professor of the Department of outpatient medicine and general practice of Kazan State Medical University; Russia 420012, Kazan, Butlerov str., 49; +7-917-396-24-17; e-mail: osigit@rambler.ru

KIM TAISIA YU., ORCID ID: 0000-0003-2370-2972; Web of Science Researcher ID: AAH-8630-2019; Scopus Author ID: 57208906994; С. Med. Sci., assistant of professor of the Department of outpatient medicine and general medical practice of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. +7-917-241-71-69, e-mail: tais_ariana@mail.ru

KHASANOVA MILYAUSHA I., ORCID ID: 0000-0003-4836-2927; Scopus Author ID 57192175615; C. Med. Sci., associate professor of the Department of urology and nephrology of Kazan State Medical Academy – the branch of Russian Medical Academy of Postgraduate Education; Russia, 420012, Kazan, st. Mushtari str., 11; +7-903-307-67-32; e-mail: milyash@ inbox.ru

Abstract. Introduction. When treating urinary tract infections, especially lower urinary tract cystitis and asymptomatic bacteriuria, quite a few factors have to be considered, such as rst episode of cystitis or recurrence, presence of pregnancy or lactation, suspected pathogen and its sensitivity/resistance to antimicrobial agents in the region, recent antibiotic treatment and many others. One such factor that determines disease outcome is the rational choice of empirical antimicrobial therapy. The results of domestic and foreign epidemiological studies indicate a global increase in resistance of uropathogens to antibiotics, which has in uenced the change of modern strategy and tactics of antimicrobial therapy. Aim. To review current data on the results of epidemiological and clinical studies and substantiate clinical recommendations for rational empirical therapy of uncomplicated lower urinary tract infections. Material and methods. The original epidemiological and clinical studies in the foreign and domestic literature and clinical guidelines on the topic for the last 5 years were searched. Results and its discussion. Data from epidemiological studies of community-acquired urinary tract infections in the Russian Federation show decreasing sensitivity and increasing resistance among outpatient strains of uropathogenic E. coli and Klebsiella pneumoniae to antibiotics commonly used in outpatient practice: uoroquinolones, betalactams (including protected ones), cephalosporins, trimethoprim/sulfamethoxazole. which was a prerequisite for limiting the use of many antibiotics widely used in the treatment of urinary tract infections in the last decade. The ndings were the basis for changes in the strategy and tactics of empirical antimicrobial therapy, in particular to the exclusion of quinolones/ uoroquinolones and restriction of betalactams from the treatment of uncomplicated cystitis. This review presents indications for a rational choice of empirical antimicrobial therapy for acute and recurrent cystitis and asymptomatic bacteriuria: recommended regimens, doses and duration of therapy. Conclusion. The decision to prescribe antibiotic therapy for lower urinary tract infections should be made after ineffectiveness and non-antimicrobial prophylaxis, and the choice of antibiotic should be based on its environmental safety and prevention of global antimicrobial resistance buildup.

Key words: сystitis, asymptomatic bacteriuria, clinical guidelines, empirical antimicrobial therapy.

For reference: Sigitova ON, Kim TYu, Khasanova MI. Lower urinary tract infections (cystitis, bacteriuria) in outpatients practice: changing the strategy and tactics of empirical antimicrobial therapy (new clinical recommendation/Bulletin of Contemporary Clinical Medicine. – 2022; 15(4):94-101. DOI:10.20969/VSKM.2022.15(4).94-101.

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УДК: 616.381-002:616.34-007.43:616.25-003.215 DOI:10.20969/VSKM.2022.15(4).102-108

PDF download APPLICATION OF THE ERAS PROTOCOL IN EMERGENCY SURGERY

SHARIPOVA VISOLATKHON H., ORCID ID: 0000-0003-2517-1183; Dос. Med. Sci, Head of the Department of Anesthesiology and Intensive Care, Republican Research Center of Emergency Medicine, Tashkent, Uzbekistan, 100107, Farhad str.2, e-mail: visolat_78 @ mail.ru.

BOKIEV KOMILJON SH., ORCID ID: 0000-0002-9472-4020; Head of Surgery Intensive Care Department of Republican Research Center of Emergency Medicine, Tashkent, Uzbekistan, 100107, Farhad str.2, e-mail: kbokiyev@mail.ru

ALIMOV AZAMAT H., ORCID ID: 0000-0001-5777-6166; Anesthesiologist and Surgery Intensive Care Department doctor of Republican Research Center of Emergency Medicine, Tashkent, Uzbekistan, 100107, Farhad str.2, e-mail: azamat. kh.alimov@gmail.com

Abstract. Introduction. The successful application of the ERAS (Enhanced Recovery After Surgery) protocol in elective surgery stimulates many researches to think about implementation in emergency surgery for the early recovery of patients undergoing emergency laparotomy. Aim. Analysis of scienti c medical literature on the use of the ERAS protocol (Enhanced Recovery After Surgery) in patients undergoing emergency surgery. Material and methods. A review and analysis of current scienti c data about the use of the ERAS protocol in patients with homeostasis disorders in need of emergency surgical intervention in the PubMed and Google Scholar search databases was carried out. Results and discussion. Publication about the using of ERAS protocol in emergency surgical pathology is aimed at patients with a stable general condition. The complexity of applying the concept of recovery of patients after emergency surgery lies in the fact that the doctors are faced with a patient with disturbed homeostasis, which arose as a result of a catastrophe in the abdominal cavity. Without the possibility of preoperative preparation due to the urgency of the surgical intervention, the anesthesiologist is not able adhere to the concept in the preoperative period. Sepsis, septic shock and the severity of the patient conditions, intoxication, hypovolemia, comorbidity, the inability to use mini-invasive surgery limits the possibility of using the ERAS concept in emergency surgical care. Conclusion.There is a need to introduce adapted ERAS protocols in emergency surgery, because such protocols would provide positive and promising results in the treatment of this category of patients.

Key words: protocol ERAS, emergency patient, emergency laparotomy, sepsis, septic shock.

For citation: Sharipova VH, Bokiev KSh, Alimov AH. Application of the ERAS protocol in emergency surgery. The Bulletin of Contemporary Clinical Medicine. 2022; 15 (2):102-108. DOI: 10.20969/VSKM.2022.15(2).102-108.

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57. Peden CJ, Aggarwa G, Aitken RJ, Anderson ID, Foss NB, Coope Z. Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS) Society Recommendations: Part 1 - Preoperative: Diagnosis, Rapid Assessment and Optimization. World J Surg. 2021; 45: 1272–1290. DOI: 10.1007/s00268-021-05994-9

 

ЕXPERIENCE EXCHANGE

УДК:616-035 DOI:10.20969/VSKM.2022.15(5).109-112

PDF download NEW APPROACHES IN THE TREATMENT OF PATIENTS WITH COMPLICATED DESTRUCTIVE APPENDICITIS

MALKOV IGOR S., ORCID ID: 0000-0003-2350-5178; Scopus Author ID: 7003868993; D. Med. Sci, Professor, Head of department of Surgery, Kazan State Medical Academy – Branch Campus of the Russian Medical Academy of Continuous Professional Education, 420012, Russia, Kazan, Butlerova str., 36

MAMADOV TURAL A., ORCID ID: 0000-0003-1610-2813; Surgeon, Surgery Department N2, City Clinical Hospital N7, 420132, Russia, Kazan, Chuykova str., 54

SHAKIROV MANSUR I., ORCID ID: 0000-0002-7564-763Х; C. Med. Sci., Surgeon, Surgery Department N2, City Clinical Hospital N7, 420132, Russia, Kazan, Chuykova str., 54

FILIPPOV VIACHESLAV A., ORCID ID: 0000-0001-7440-4866; Scopus Author ID: 7202667118; WoS Researcher ID: B-6934-2015; C. Med. Sci., assistant professor of department of Surgery, Kazan State Medical Academy – Branch Campus of the Russian Medical Academy of Continuous Professional Education, 420012, Russia, Kazan, Butlerova str., 36

Abstract. Introduction. The treatment of complicated forms of acute destructive appendicitis remains an urgent problem of urgent abdominal surgery. Aim. The aim of our investigation was to substantiate the use of VAC-therapy to improve the results of surgical treatment of patients with acute destructive appendicitis complicated by typhlitis and periappendicular abscess.Material and methods. The present investigation is based on the results analysis of 84 patients aged from 17 to 78 years with acute destructive appendicitis, complicated by typhlitis and periappendicular abscess, being treated at the department of surgery 2 of the State Medical Institution City Clinical Hospital 7 of Kazan. Open ligature appendectomy was performed in all cases due to pronounced in ltration of the cecum dome. Two groups of patients were singled out according to the method of surgical intervention completion. In 54 patients of the comparison group the surgical intervention was terminated by gauze-gingival drainage of the appendix bed, since there was a high probability of appendix residual limb failure and necessity of purulent process isolation from the free abdominal cavity. Penrose drainage was removed through the surgical wound. In addition, the pelvis was drained through the contraperitoneum with a tubular drain. In 30 patients of the main group after appendectomy for abdominal cavity drainage we connected a Vacuum–assisted closure-system using Vivano apparatus and consumables of Hartman, Germany. Statistical processing of the results was carried out using Statistiсa 10 software package and Miсrosoft Exсel 2010. The differences were considered statistically signi cant at p<0.05. Results and discussion. Analysis of the used surgical techniques showed that in the main group the wound postoperative complications decreased by 3 times and were 23,3%; formation of the abdominal cavity in ltrates was 2 times less; period of hospitalization decreased by 1,8 times.Conclusion. Ease of implementation of VAC-therapy method, therapeutic and economic feasibility allow us to recommend it as the nal stage of treatment of acute destructive appendicitis complicated by typhlitis and periappendicular abscess.

Key words: acute appendicitis, typhlitis, periappendicular abscess, vacuum system, Vivano device, vacuum therapy.

For reference: New approaches in the treatment of patients with complicated destructive appendicitis / Malkov IS, Mamedov TA,ВShakirov MI, Filippov VA // Bulletin of contemporary clinical medicine. 2022; 15(5):109-112. DOI: 10.20969/VSKM.2022.15(5).109-112.

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CLINICAL CASE

УДК:616-06 DOI:10.20969/VSKM.2022.15(4).113-123

PDF download CLINICAL CASE OF CESTODOSIS OF THE RIGHT LOBE OF THE LIVER

KLYUSHKIN IVAN V., ORCID ID: 0000-0002-5654-6710; Dr. med. Sci., City Clinical Hospital No. 7, Kazan, Professor, Professor of the Department of General Surgery, Kazan State Medical University, Kazan, Russia, 420012, st. Butlerova 49, 8-843-236-06-52, e-mail: hirurgivan@mail.ru

ANISIMOV ANDREY Y., ORCID ID: 0000-0003-4156-434X, Dr. med. Sci., corresponding member RANS, Professor, Head of the Department of Emergency Medical Care and Simulation Medicine, Center for Medicine and Pharmacy of the Graduate School of Medicine, Institute of Physical Medicine and Biomedical Medicine Kazan (Volga Region) Federal University, Russia, 420055, st. Karl Marx, 74, 8-843-236-65-47, e-mail: aanisimovbsmp@yandex.ru

ZAKIROVA ALFIIA M., ORCID ID: 0000-0003-2976-0807, ScopusID 56175496000, SPIN 4214-9400; Cand. Med. Sci., Associate Professor, Associate Professor, Department of Propaedeutics of Childhood Diseases and Pediatrics, Kazan State Medical University, Kazan, Russia, 420012, st. Butlerova 49, 8-843-236-06-52, e-mail: azakirova@gmail.com

Abstract. Introduction. Echinococcosis, belonging to the group of cestodosis, forms at one of the stages of development an echinococcal cyst with mechanical compression of the surrounding tissues. In the case of the addition of bacterial ora, infection of the cyst occurs and the formation of a volumetric in ammatory process in the affected organ. In the future, symptoms of an acute in ammatory process with the formation of an abscess are recorded, an inevitable opening of the abscess or its ossi cation occurs and the development of a clinical picture of involvement of neighboring organs in the process. Aim. Describe a clinical case of cestodosis of the right lobe of the liver. Material and methods. Patient B., 46 years old, was hospitalized in the surgical department with complaints of weakness, jaundice and slight itching of the skin. Conducted general clinical, laboratory and instrumental research methods. The article describes in detail the history of the disease, clinical manifestations, the results of laboratory and instrumental examination methods with pathomorphological examination of the cyst, conservative and surgical treatment with a description of the course of the operation. Results and discussion. The surgery was successful. The patient was discharged in satisfactory condition with a clinical diagnosis: cestodosis of the right lobe of the liver (echinococcosis), formation of S8 of the left lung, subacute thrombosis of the right internal jugular vein on the 26th day after the operation. Medical and labor recommendations were given. Conclusion.These data are necessary for practicing physicians in the differential diagnosis of various nosological forms and diseases of internal organs for the correct diagnosis.

Key words: cestodosis, echinococcal cyst of the liver, surgical treatment, anatomical resection of the liver.

For reference: Klyushkin IV, Anisimov AYu, Zakirova AM. Clinical case of cestodosis of the right lobe of the liver // The Bulletin of Contemporary Clinical Medicine. - 2022. 15(4).113-123. DOI: 10.20969/VSKM.2022.15(4).113-123.

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HISTORY OF MEDICINE

УДК:61(091) DOI:10.20969/VSKM.2022.15(4).124-130

PDF download SERGEY PETROVICH BOTKIN: TO THE JUBILEE OF A DOCTOR, A TEACHER, A RESEARCHER AND PUBLIC FIGURE

ZINKEVICH ELENA R., ORCID ID: 0000-0003-2630-3395; Scopus ID: 57195053315; D. ped. Sci., associate professor, professor of Department general and applied psychology with courses in biomedical disciplines and pedagogy of the St. Petersburg State Pediatric Medical University, 194100, Russia, St. Petersburg, Litovskaya str., 2, e-mail: lenazinkevich@mail.ru

KULBACH OLGA S., ORCID ID: 0000-0002-2502-2973; Scopus ID: 57195103491; D. med. sci., professor of Department general and applied psychology with courses in biomedical disciplines and pedagogy of the St. Petersburg State Pediatric Medical University, 194100, Russia, St. Petersburg, Litovskaya str., 2, e-mail: os_koulbakh@mail.ru

ZAVARZINA NATALIA U., ORCID ID: 0000-0001-9152-8641; Scopus ID: 6507380470; C. biol. sci., associate professor of Department general and applied psychology with courses in biomedical disciplines and pedagogy of the St. Petersburg State Pediatric Medical, 194100, Russia, St. Petersburg, Litovskaya str., 2, e-mail: nzavarzina@mail.ru

Abstract. Introduction. On the 190th jubilee of Sergei Petrovich Botkin, an appeal to his memory of his merits is evidence of the caring attitude of the current generation to the Russian medical heritage, allowing to preserve the continuity of professional generations. Aim. The purpose of the study is to show the role of the personality of S.P. Botkin in the development of scienti c clinical medicine, in the formation of military medicine eld and sanitary medicine in Russia. In the course of theoretical research, signi cant personal qualities of S.P. Botkin, his clinical experience, the in uence of research results on the development of the physiological direction of clinical medicine, the formation of Russian military eld medicine and the military sanitary industry in Russia were revealed. Material and methods. The research was carried out based on of theoretical analysis of literature on the history of Russian medicine and medical education, letters of S.P. Botkin. The historical observation covers the period from the beginning of the 30s up to the 90s years of the XIX century. Results and discussion. The study of articles and materials illustrating the life path of S.P. Botkin, his achievements in the eld of the physiological direction of scienti c clinical medicine, military eld and military sanitary medicine, allowed us to identify a number of individual and personal qualities of this person, which as a whole determined his professional formation and in uenced the entire course of development of a number of branches of scienti c and medical knowledge. Purposefulness, originality, charisma of the scientist, his perseverance and persistence, courage and creative passion have become signi cant personality traits that allowed his inclinations as a researcher, doctor, teacher and public gure to be revealed. Conclusion. In the course of theoretical research, it was possible to identify a number of signi cant personal qualities of S.P. Botkin, analyze his clinical experience, research, pedagogical and social activities, which made it possible to highly appreciate his contribution to the world medical science and practice, to the development of domestic public health, to the improvement of the military sanitary industry in Russia.

Keywords: history of medicine, physiological direction of clinical medicine, Russian medical heritage.

For reference: Zinkevich ER, Kulbach OS, Zavarzina NY. Sergey Petrovich Botkin: to the jubilee of a doctor, a teacher, a researcher and public gure. The Bulletin of Contemporary Clinical Medicine. 2022; 15(4):124-130. DOI: 10.20969/ VSKM.2022.15(4).124-130. 

References

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  7. Журавский С.Г. Дневники медика С.П. Боткина как энциклопедия медицины Российского императорского двора // История медицины. – 2016. – Т. 3., No3. – С. 145-158. [Zhuravskij SG. Dnevniki medika S.P. Botkina kak enciklopediya mediciny Rossijskogo imperatorskogo dvora [The diaries of the physician S.P. Botkin as an encyclopedia of medicine of the Russian Imperial Court]. Istoriya mediciny [History of Medicine]. 2016; 3(3): 145- 158 (In Russ.)]. DOI: 10.17720/2409-5583.t3.2.2016.14g

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  14. Ковалевский А.В. Ученик и последователь С.П. Боткина В.И. Алышевский, главный врач Мариинской больницы // Материалы Четвёртой Международной научно-практической конференции. – 2021. – С. 20-32. [Kovalevskij AV. Uchenik i posledovatel’ S.P. Botkina V.I. Alyshevskij, glavnyj vrach Mariinskoj bol’nicy [Disciple and follower of S.P. Botkin V.I. Alyshevsky, chief physician of the Mariinsky Hospital]. Materialy Chetvyortoj Mezhdunarodnoj nauchno-prakticheskoj konferencii [Materials of the Fourth International Scienti c and Practical Conference]. 2021: 20-32. (In Russ.)]

  15. Бородулин В.И. Роль казанских терапевтов в развитии боткинского направления в первой половине XX века // Казанский медицинский журнал. – 2021. – Т. 102. No3. – С. 395-399. [Borodulin VI. Rol’ kazanskih terapevtov v razvitii botkinskogo napravleniya v pervoj polovine XX veka [The role of Kazan therapists in the development of the Botkin direction in the rst half of the XX century]. Kazanskij medicinskij zhurnal [Kazan Medical Journa]. 2021; 102. (3): 395-399. (In Russ.)]. DOI: 10.17816/KMJ2021-395Ventricular Ejection Fraction Assessment. Card Fail Rev. 2017;3(2):97-101. DOI: 10.15420/cfr.2017:14.1