Vol. 17 Issue 6 (2024)

VSKM 2024 N 6

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ORIGINAL RESEARCH

Buccal ureteroplasty for recurrent extended strictures and obliterations in the upper urinary tract: short- and long-term surgery outcomes Volkov A.A. (Russia, Rostov-on-Don), Budnik N.V. (Russia, Rostov-on-Don), Memetov S.S. (Russia, Rostov-on-Don), Mustapayev I.D. (Russia, Rostov-on-Don), Nikitina M.A. (Russia, Rostov-on-Don) P. 7

Thrombocytopenia and С-reactive protein as markers of hemorrhagic fever with renal syndrome, complicated by acute kidney failure Galimova S.Sh. (Russia, Ufa), Abdrakhmanova N.I. (Russia, Ufa), Sebyakina I.D. (Russia, Moscow), Galimov Sh.N. (Russia, Ufa), Mochalov K.S. (Russia, Ufa), Galimov K.Sh. (Russia, Moscow), Fedorovtseva Zh.G. (Russia, Ufa), Sadykova A.R. (Russia, Ekaterinburg), Galimova E.F. (Russia, Ufa), Litvitskii P.F. (Russia, Moscow) P. 13

Modified SWOT analysis to investigate the operational environment of a pharmaceutical distributor Goryachev A.B. (Russia, Moscow), Urusova L.Kh. (Russia, Pyatigorsk), Kabakova T.I. (Russia, Pyatigorsk), Kuvshinova N.N. (Russia, Moscow), Afanasiev O.N. (Russia, Moscow), Lemeshchenko E.Yu. (Russia, Moscow) P. 19

Prognostic value of fecal markers in the diagnosis of axial spondyloarthritis associated with Crohn’s disease Davydov D.A. (Russia, Saint Petersburg), Marchenko V.N. (Russia, Saint Petersburg), Kuznetsova D.A. (Russia, Saint Petersburg), Lapin S.V. (Russia, Saint Petersburg), Rubinstein A.A. (Russia, Saint Petersburg), Shchukina O.B. (Russia, Saint Petersburg) P. 28

Influence of respiratory tuberculosis chemotherapy on the ability of neutrophils to form extracellular traps Zolotov A.N. (Russia, Omsk), Novikov D.G. (Russia, Omsk), Dyachenko E.I. (Russia, Omsk), Mordyk A.V. (Russia, Omsk), Romanova M.А. (Russia, Omsk), Indutny A.V. (Russia, Omsk), Kirichenko N.А. (Russia, Omsk), Holodenko A.О. (Russia, Omsk), Pereskok A.V. (Russia, Omsk) P. 37

Routing plan for patients with malignant neoplasms in a private medical organization Minaeva A.K. (Russia, Moscow), Lisaev D.A. (Russia, Moscow), Konovalov O.E. (Russia, Moscow), Shulaev A.V. (Russia, Kazan), Pak V.I. (Russia, Moscow) P. 43

Effect provided by inhaled salbutamol on exhaled breath signatures in adult patients with cystic fibrosis Mustafina M.Kh. (Russia, Moscow), Krasovsky S.A. (Russia, Moscow), Silantyev A.S. (Russia, Moscow), Suvorov A.Yu. (Russia, Moscow), Kopylov Ph.Yu. (Russia, Moscow) P. 49(Russia, Moscow), Kopylov Ph.Yu. (Russia, Moscow) P. 49

Immunogenetic characteristics of the clinical course of psoriasis vulgaris in the inhabitants of Kemerovo region Romanova E.L. (Russia, Kemerovo), Shabaldin A.V. (Russia, Kemerovo), Belov Ye.G. (Russia, Kemerovo), Striga L.V. (Russia, Kemerovo), Yakovleva A.A. (Russia, Kemerovo), Shevchenko E.A. (Russia, Kemerovo), Shabaldina E.V. (Russia, Kemerovo) P. 56

Morphological picture of acute kidney injury in young children after cardiac surgery Khaydarov A.E. (Uzbekistan, Tashkent), Mardonov J.N. (Uzbekistan, Tashkent), Sobirov D.M. (Uzbekistan, Tashkent), Khalikulov Kh.G. (Uzbekistan, Tashkent), Irmatov S.Kh. (Uzbekistan, Tashkent) P. 65

Effectiveness of pericapsular nerve group block in proximal femoral fractures Sharipova V.H. (Uzbekistan, Tashkent), Abdulkhamidov A.A. (Uzbekistan, Ferghana), Alimov A.H. (Uzbekistan, Tashkent) P. 71

REVIEWS

Headaches in Chiari malformation Sakovets T.G. (Russia, Kazan), Bogdanov E.I. (Russia, Kazan) P. 78

Comorbidity as a factor of gastroduodenal ulcer development in elderly and senile patients Sakhabetdinova K.N. (Russia, Kazan), Sakhabetdinov B.A. (Russia, Kazan), Amirov N.B. (Russia, Kazan) P. 84

PRACTICAL EXPERIENCE

Staged liver resection using ALPPS technology: an innovative surgical technique for the treatment of multiple colorectal liver metastases Anisimov A.Yu. (Russia, Kazan), Мavlonov F.B. (Tajikistan, Dushanbe) P. 97

Using calculations in the reconstructive surgery of static forefoot deformity (case report) Leonova S.N. (Russia, Irkutsk), Usoltsev I.V. (Russia, Irkutsk), Kosareva M.A. (Russia, Irkutsk), Vasilev V.Y. (Russia, Irkutsk) P. 105

Internal pancreatic fistula in a patient with acute destructive pancreatitis associated with systemic connective tissue diseases Lukashew A.D. (Russia, Kazan), Kurochkin S.V. (Russia, Kazan), Tagirov M.R. (Russia, Kazan), Zakirova E.B. (Russia, Kazan), Makarov D.V. (Russia, Kazan) P. 112

Mobile claw toe syndrome (Checkrein deformity): a clinical case Usoltsev I.V. (Russia, Irkutsk), Leonova S.N. (Russia, Irkutsk), Gubar I.E. (Russia, Irkutsk), Vasilev V.Yu. (Russia, Irkutsk) P. 120

ORGANIZATION OF HEALTHCARE

Medical and organizational aspects of optimizing the admitting department activities in an emergency hospital Banin I.N. (Russia, Voronezh), Konovalov O.E. (Russia, Moscow), Shulaev A.V. (Russia, Kazan), Breusov A.V. (Russia, Kursk) P. 128

Trends in demographic processes: marriage, divorce, and birth rates within the Kursk region in 2012–2022 Breusov A.V. (Russia, Kursk), Ryndina V.V. (Russia, Kursk), Solyanina V.A. (Russia, Kursk), Shulaev A.V. (Russia, Kazan), Oleynikova T.A (Russia, Kursk), Stepanova A.V. (Russia, Kursk) P. 134

EXPERIMENTAL STUDIES – TO CLINICAL MEDICINE

Studying the mitochondrial toxicity of paracetamol and its metabolite NAPQI Vlasova Yu.A. (Russia, Saint Petersburg), Batrakova K.V. (Russia, Saint Petersburg), Golovanova N.E. (Russia, Saint Petersburg), Tuvaleva L.S., (Russia, Ufa), Kuramshina O.A. (Russia, Ufa), Nigmatullin R.Kh. (Russia, Ufa), Grishina A.R. (Russia, Saint Petersburg), Usacheva K.V. (Russia, Saint Petersburg) P. 141

Features of bone remodeling during the use of antisense oligonucleotides in a rheumatoid arthritis model Makalish T.P. (Russia, Simferopol), Golovkin I.O. (Russia, Simferopol), Maslova G.V. (Russia, Simferopol), Pilyavsky N.N. (Russia, Simferopol), Marulova A.V. (Russia, Simferopol) P. 146

ANNIVERSARIES

Department of public health and healthcare of the privolzhsky research medical university: a historical forge of research personnel – healthcare professionals (On the occasion of the 125th anniversary of the birth of Sophia I. Skundina) Gurvich N.I. (Russia, Nizhny Novgorod), Kopteva L.N. (Russia, Nizhny Novgorod), Perevezentsev E. A. (Russia, Nizhny Novgorod), Kafidova T.I. (Russia, Nizhny Novgorod), Postnikova A.D. (Russia, Nizhny Novgorod), Baranov A.D. (Russia, Nizhny Novgorod) P. 154

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ORIGINAL RESEARCH

УДК: 616.613+616.617-036.83-089.844

DOI: 10.20969/VSKM.2024.17(6).7-12

PDF download BUCCAL URETEROPLASTY FOR RECURRENT EXTENDED STRICTURES AND OBLITERATIONS IN THE UPPER URINARY TRACT: SHORT- AND LONG-TERM SURGERY OUTCOMES

VOLKOV ANDREY A., ORCID ID: 0000-0001-8374-191Х; Scopus Author ID: 57197444695, Cand. sc. med., Head of the Surgical Center, Hospital for War Veterans, 27 26-ya liniya str., 344020 Rostov-on-Don, Russia. E-mail: Volkov73a@bk.ru

BUDNIK NIKOLAY V., ORCID ID: 0000-0002-9672-2571; Cand. sc. med., Head of the Hospital for War Veterans, 27 26-ya liniya str., 344020 Rostov-on-Don, Russia. E-mail: budnik@rambler.ru

MEMETOV SERVIR S., ORCID ID: 0000-0002-9672-2571; Dr. sc. med., Professor at the Department of Healthcare Organization and Public Health (with a course in Computer Information Technologies in Healthcare and Medicine), Rostov State Medical University, 29 Nakhichevansky lane, 344022 Rostov-on-Don, Russia; Deputy Head of the Hospital for War Veterans, 27 26-ya liniya, 344020 Rostov-on-Don, Russia. E-mail: memetov.57@mail.ru

MUSTAPAYEV IRBAIKHAN D., ORCID ID: 0000-0003-4974-4310; Urologist at the Surgical Center, Hospital for War Veterans, 27 26-ya liniya, 344020 Rostov-on-Don, Russia. E-mail: Irba83@mail.ru

NIKITINA MARGARITA A., ORCID ID: 0009-0003-3581-1583; 6th-year student at the Pediatric Faculty, Rostov State Medical University, 29 Nakhichevansky lane, 344022 Rostov-on-Don, Russia. E-mail: panda.romashko@ yandex.ru

Abstract. Introduction. Buccal ureteroplasty is an operation that has been increasingly used in reconstructive urology in recent years. Its role becomes especially important due to the growing number of strictures of the upper urinary tract, which arise in association with the widespread use of endourological techniques. The article presents our own experience of using the oral mucosa in the surgical treatment of recurrent extended strictures and obliterations in the upper urinary tract. Aim. To study the short- and long-term outcomes of buccal ureteroplasty, complications of this operation, and methods for their correction. Materials and Methods. The treatment outcomes were studied in 37 patients who underwent 40 buccal ureteroplasties. The interventions differed in accesses, surgical techniques, and buccal graft revascularization methods. Postoperative complications were assessed according to the Clavien-Dindo classification of surgical complications. Results and Discussion. Early postoperative complications were detected in 16 patients (42.1%), and late complications in 10 patients (26.3%). All complications were Grades 1-23b according to this classification. The results obtained show that there were no severe complications in patients in the early and late postoperative periods, and there was a small number of obstruction relapses. Surgery efficacy was 91.2%; all subsequent relapses were successfully eliminated. Conclusions. Buccal ureteroplasty is an intervention that has a small number of severe complications and relapses and can be used to eliminate obstruction in the upper urinary tract. Keywords: buccal graft ureteroplasy, buccal graft, extended ureteral stricture, extended obliteration of the ureter.

For reference: Volkov AA, Budnik NV, Memetov SS, et al. Buccal ureteroplasty for recurrent extended strictures and obliterations in the upper urinary tract: Short- and long-term surgery outcomes. The Bulletin of Contemporary Clinical Medicine. 2024; 17 (6): 7-12. DOI: 10.20969/VSKM.2024.17(6).7-12.

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УДК 616-092.11 -616.-002.1

DOI: 10.20969/VSKM.2024.17(6).13-18

PDF download THROMBOCYTOPENIA AND C-REACTIVE PROTEIN AS MARKERS OF HEMORRHAGIC FEVER WITH RENAL SYNDROME, COMPLICATED BY ACUTE KIDNEY FAILURE

GALIMOVA SAIDA SH., ORCID ID: 0000-0002-7865-8326; SCOPUS Author ID: 58176429300, Assistant Professor at the Department of Therapy and General Medical Practice with a Course in Geriatrics, Bashkir State Medical University,
3 Lenin str., 450008 Ufa, Russia. E-mail: saida9319@mail.ru

ABDRAKHMANOVA NURIYA I., ORCID ID: 0009-0007-7573-7196; Head of Infectious Diseases Department No. 3, Republican Clinical Infectious Diseases Hospital No. 4, 37 Zapototsky str., 450015 Ufa, Russia. E-mail: nuria.abdrahmanova@mail.ru

SEBYAKINA IRINA D., ORCID ID: 0009-0007-9707-2623; 6th-year student, I. M. Sechenov First Moscow State Medical University, 8 Trubetskaya str., Bldg. 2, 119991 Moscow, Russia. E-mail: isebyakina@yandex.ru

GALIMOV SHAMIL N., ORCID ID: 0000-0002-5871-5151; SCOPUS Author ID: 6602936166, Dr. sc. med., Professor, Head of the Department of Biological Chemistry, Bashkir State Medical University, 3 Lenin str., 450008 Ufa, Russia.
E-mail: sngalim@mail.ru

MOCHALOV KONSTANTIN S., ORCID ID: 0000-0002-8010-3338; SCOPUS Author ID: 57196260033, Cand. sc. biol, Associate Professor, Department of Fundamental and Applied Microbiology, Bashkir State Medical University, 3 Lenin str., 450008 Ufa, Russia. E-mail: kostja.mochalov@yandex.ru

GALIMOV KAMIL SH., ORCID ID: 0000–0002–0148–4380; SCOPUS Author ID: 57221733482; Postgraduate Student, Department of Pathological Physiology, I. M. Sechenov First Moscow State Medical University, 8 Trubetskaya st., Bldg. 2, 119991 Moscow, Russia. E-mail: kamil9819@mail.ru

FEDOROVTSEVA ZHANNA G., ORCID ID: 0009-0006-6689-1223; 1st-year student, Bashkir State Medical University, 3 Lenin str., 450008 Ufa, Russia. E-mail: zhanna.fedorovceva@gmail.com

SADYKOVA AILINA R., ORCID ID: 0009-0004-2289-9106; 1st-year student, Institute of Natural Sciences and Mathematics, Ural Federal University, 19 Mira str., 620002 Ekaterinburg, Russia. E-mail: AlinaRS@yandex.ru.

GALIMOVA ELMIRA F., ORCID ID: 0000-0002-3351-7669; SCOPUS Author ID: 8332586100, Dr. sc. med., Professor, Department of Pathological Physiology, Bashkir State Medical University, 3 Lenina str., 450008 Ufa, Russia.
E-mail: efgalimova@mail.ru

LITVITSKII PETR F., ORCID ID: 0000-0003-0151-9114; SCOPUS Author ID: 6602403952; Dr. sc. med., Professor, Department of Pathological Physiology, I. M. Sechenov First Moscow State Medical University, 8 Trubetskaya st., Bldg. 2, 119991 Moscow, Russia. E-mail: lisovikp@mail.ru

Abstract. Introduction. Hemorrhagic fever with renal syndrome is a common zoonotic disease that can lead to acute kidney failure in severe cases. Although there has been a lot of research on clinical and laboratory indicators, there are no specific markers to identify cases of hemorrhagic fever with renal syndrome, complicated by acute kidney failure. This study aims to examine platelet production and inflammatory factors in laboratory tests as potential markers for identifying this complication. Materials and Methods. 135 patients were examined. The group with mild to moderate disease consisted of 62 individuals, and the group with severe disease without acute kidney failure included 73 individuals. Blood tests, including complete blood count and biochemical analysis, were performed on all patients. Clinical and laboratory data were used to establish the diagnosis in accordance with clinical recommendations. The following parameters were studied: Leukocytes, erythrocytes, hemoglobin, platelets, prothrombin time, C-reactive protein, total protein, serum creatinine, blood urea nitrogen, glucose, and potassium ions. Parametric statistical methods were used. Results and Discussion. Substantial changes were found in most parameters analyzed at all severity levels of hemorrhagic fever. Platelet levels below 60 x 109/L, as well as significantly increased C-reactive protein levels exceeding 30 mg/L, preceded the development of acute kidney failure. Conclusions. Thrombocytopenia and high C-reactive protein levels may be considered the early signs of hemorrhagic fever complicated by acute kidney failure.

Keywords: acute kidney failure, C-reactive protein, platelets, hemorrhagic fever with renal syndrome, oliguric/anuric syndrome.

For reference: Galimova SSh, Abrahmanova NI, Sebyakina ID, et al. Thrombocytopenia and C-reactive protein as markers of hemorrhagic fever with renal syndrome, complicated by acute kidney failure. The Bulletin of Contemporary Clinical Medicine. 2024; 17 (6): 13-18. DOI: 10.20969/VSKM.2024.17(6).13-18.

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УДК 614.273:615.15

DOI: 10.20969/VSKM.2024.17(6).19-27

PDF download MODIFIED SWOT ANALYSIS TO INVESTIGATE THE OPERATIONAL ENVIRONMENT OF A PHARMACEUTICAL DISTRIBUTOR

GORYACHEV ANDREY B., ORCID ID: 0000-0002-6844-4578, Scopus Author ID: 25642462600, Dr. sc. pharm., Associate Professor, Professor at the Department of Life Safety and Disaster Medicine, Sechenov First Moscow State Medical University (Sechenov University), 2 bld., 8 Trubetskaya str., 119991 Moscow, Russia. Tel.: +7 (916) 282-93-29. E-mail: abgor61@gmail.com

URUSOVA LEYLA Kh., ORCID ID: 0000-0002-4829-2642, Scopus Author ID: 58499897400, Postgraduate Student at the Department of Pharmacy, Pyatigorsk Medical and Pharmaceutical Institute – A Branch of Volgograd State Medical University, 11 Kalinin Ave., 357532 Pyatigorsk, Russia. Tel.: +7 (918) 714-66-17. E-mail: flora0996@mail.ru

KABAKOVA TAISIA I., ORCID ID: 0000-0001-6182-5637, Scopus Author ID: 57207985290, Dr. sc. pharm., Associate Professor, Professor at the Department of Organization and Economics of Pharmacy, Pyatigorsk Medical
and Pharmaceutical Institute – A Branch of Volgograd State Medical University, 11 Kalinin Ave., 357532 Pyatigorsk, Russia. Tel.: +7 (905) 446-07-62. E-mail: kabtais@mail.ru

KUVSHINOVA NATALYA N., ORCID ID: 0000-0003-1826-5237, Scopus Author ID: 57216210402, Cand. sc. biol., Associate Professor, Associate Professor at the Department of Life Safety and Disaster Medicine, Sechenov First Moscow State Medical University (Sechenov University), 2 bld., 8 Trubetskaya str., 119991 Moscow, Russia. Tel.: +7 (965) 208-08-56. E-mail: gaidamovich@yandex.ru

AFANASIEV OLEG N., ORCID ID: 0000-0002-0943-5203, Scopus Author ID: 57203531233, Senior Teacher at the Department of Life Safety and Disaster Medicine, Sechenov First Moscow State Medical University (Sechenov University),
2 bld., 8 Trubetskaya str., 119991 Moscow, Russia. Tel.: +7 (926) 412-69-41. E-mail: diduevich@rambler.ru

LEMESHCHENKO ELENA Yu., ORCID ID: 0009-0009-0836-3766, Scopus Author ID: 57203530379, Senior Teacher at the Department of Life Safety and Disaster Medicine, Sechenov First Moscow State Medical University (Sechenov University), 2 bld., 8 Trubetskaya str., 119991 Moscow, Russia. Tel.: +7 (910) 491-07-24. E-mail: elem61@mail.ru

Abstract. Introduction. Modern marketing methods are the tools of research in various areas of scientific, economic, educational, social and other activities. SWOT analysis is one of the most popular marketing techniques. Like all marketing analysis methods, SWOT analysis has some advantages, including its ease of use and no financial cost of searching, generalizing, and analyzing the initial information, as well as the evaluability of the current state and the predictability of the developments at various planning horizons. Key disadvantages of SWOT analysis: Verbal (not numerical) format of primary data, the impossibility to track the historical data in the future, and the lack of a clear cause-effect and logical relationship between the factors analyzed, which leads to the prevalence of the researchers’ subjective views on the same processes and phenomena. Aim. Development of a modified SWOT analysis to study the pharmaceutical distributor’s operational environment using the mathematical apparatus of processing the experts’ verbal opinions expressed numerically and its practical testing. Materials and Methods. The factors were determined to evaluate the SWOT analysis of the operational environment of a model pharmaceutical distributor in real regional conditions. Intensity of the cross effect of the evaluation factors was identified using a sociological survey of the professional expert group. At the same time, the experts’ verbal opinions were expressed numerically according to the intensity scale proposed: From 1 (minimum) to 5 (maximum). The survey data were processed mathematically using the geometric mean function. The resulting data obtained were ranked by intensity levels according to the developed ranges of numerical values. Results and Discussion. The final matrix of the reciprocal effect intensities of the evaluated factors was formed. Objective data of the SWOT analysis of the pharmaceutical distributor’s operational environment are obtained for four segments of the final matrix, and resource reserves for improving its economic efficiency and problems are identified that can cause significant economic and reputational damage in case of preventive failure to take appropriate organizational and practical decisions. Based on the SWOT-analysis results, the trajectory of a pharmaceutical distributor’s sustainable development was proposed for the conditions of the regional pharmaceutical market. Conclusions. The modified SWOT analysis proposed significantly increased the objectivity of investigating the pharmaceutical distributor’s operational environment, and its practical testing allowed us to justify the areas for strengthening competitiveness and profitability.

Keywords: SWOT analysis, evaluative factors, sociological survey, mutual influence intensity, pharmaceutical distributor

For reference: Goryachev AB, Urusova LKh, Kabakova TI, et al. Modified SWOT analysis to investigate the operational environment of a pharmaceutical distributor. The Bulletin of Contemporary Clinical Medicine. 2024; 17 (6): 19-27. DOI: 10.20969/VSKM.2024.17(6).19-27.

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УДК: 616.34-002:616.711-002.2

DOI: 10.20969/VSKM.2024.17(6).28-36

PDF download PROGNOSTIC VALUE OF FECAL MARKERS IN THE DIAGNOSIS OF AXIAL SPONDYLOARTHRITIS ASSOCIATED WITH CROHN’S DISEASE

DAVYDOV DENIS A., ORCID ID: 0000-0002-5524-1616; Scopus Author ID: 57217159189; Researcher ID: JWP-2975-2024, Postgraduate Student, Hospital Therapy Department, Pavlov University, 6-8 L’va Tolstogo str., 197022 Saint Petersburg, Russia. Tel.: +7 (981) 765-27-21. E-mail: davydov.rheum@gmail.com

MARCHENKO VALERIY N., ORCID ID: 0000-0002-2440-7222; Scopus Author ID: 57206419660; Dr. sc. med., Professor, Hospital Therapy Department, Pavlov University, 6-8 L’va Tolstogo str., 197022 Saint Petersburg, Russia. E-mail: marchvn@mail.ru

KUZNETSOVA DARIA A., ORCID ID: 0000-0001-5318-354X; Scopus Author ID: 57205585994; Cand. sc. med., Physician at the Laboratory for Diagnosis of Autoimmune Diseases, Center of Molecular Medicine, Pavlov University,
6-8 L’va Tolstogo str., 197022 Saint Petersburg, Russia. E-mail: lariwar@mail.ru

LAPIN SERGEY V., ORCID ID: 0000-0002-4998-3699; Scopus Author ID: 7006205727; Cand. sc. med., Head of the Laboratory for Diagnosis of Autoimmune Diseases, Center of Molecular Medicine, Pavlov University, 6-8 L’va Tolstogo str., 197022 Saint Petersburg, Russia. E-mail: svlapin@mail.ru

RUBINSTEIN ARTEM A., ORCID ID: 0000-0002-8493-5211; Scopus Author ID: 57417440100; Resident, Department of General Practice (Family Medicine), Pavlov University, 6-8 L’va Tolstogo str., 197022 Saint Petersburg, Russia.
E-mail: arrubin6@mail.ru

SHCHUKINA OKSANA B., ORCID ID: 0000-0001-8402-0743; Scopus Author ID: 35761206900. MD, Dr. sc. med., Professor, Department of General Practice (Family Medicine), Pavlov University, 6-8 L’va Tolstogo str., 197022 Saint Petersburg, Russia. E-mail: burmao@gmail.com

Abstract. Introduction. Spondyloarthritis is presented by various chronic diseases, including classical axial spondyloarthritis and spondyloarthritis associated with inflammatory bowel diseases, particularly Crohn’s disease. Diagnosis of the latter one may be difficult due to chronic subclinical intestinal inflammation in classic axial spondyloarthritis characterized by the increased fecal calprotectin levels in 40-70% of cases. Gut eosinophilic inflammation to be detected by fecal eosinophilic neurotoxin plays an important role in the Crohn’s disease pathogenesis. Aim. To examine differences in the fecal calprotectin and eosinophilic neurotoxin concentrations in patients with axial spondyloarthritis, Crohn’s disease, and their combination and to establish the significance of biomarkers in the differential diagnosis of classical and Crohn’s disease-associated axial spondyloarthritis. Materials and Methods. 16 patients with axial spondyloarthritis associated with Crohn’s disease (group A), 29 patients with axial spondyloarthritis (group B), and 25 patients with Crohn’s disease (group C) were examined. Calprotectin and eosinophil-derived neurotoxin in feces were studied by enzyme-linked immunosorbent assay. Statistical analysis was carried out using nonparametric criteria, logistic regression, and ROC-curve. Results and Discussion. A statistically significant increase in the median concentrations of fecal calprotectin (Kruskal-Wallis criterion – 8.624; p – 0.013) and eosinophil-derived neurotoxin (Kruskal-Wallis criterion – 6.605; p – 0.037) was found in group A. For both fecal markers, the differences were significant as compared to patients from group B (fecal calprotectin: U-test – 13.395; p – 0.026; eosinophil-derived neurotoxin: U-test – 11.406; p – 0.038). The value of calprotectin in stool of 177.28 μg/g and above have allowed to correctly classify patients of groups A and B in 76.2% of cases, and the level of eosinophilic neurotoxin of 0.745 μg/g and above – in 78.6% of cases; the area under the ROC-curve has been 0.903 (p – 0.001) for fecal calprotectin and 0.882 (p – 0.002) for eosinophil-derived neurotoxin. Combined model with fecal calprotectin 120.32 μg/g and above and eosinophil-derived neurotoxin 0.700 μg/g and above have had an accuracy of 84.0% (sensitivity – 87.5%, specificity – 77.8%). Conclusions. A combined study of fecal calprotectin and eosinophil-derived neurotoxin with the cut-off levels of 120.32 μg/g and 0.700 μg/g, respectively, allows differentiating Crohn’s disease-associated and classical axial spondyloarthritis more accurately than an isolated assessment of these markers.

Keywords: axial spondyloarthritis, inflammatory bowel diseases, Crohn’s disease, eosinophil-derived neurotoxin, eosinophilic protein X, fecal calprotectin.

For reference: Davydov DA, Marchenko VN, Kuznetsova DA, et al. Prognostic value of fecal markers in the diagnosis of axial spondyloarthritis associated with Crohn’s disease. The Bulletin of Contemporary Clinical Medicine. 2024; 17(6): 28-36. DOI: 10.20969/VSKM.2024.17(6).28-36.

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УДК: 616.24-002.5–08+ 616.155.34

DOI: 10.20969/VSKM.2024.17(6).37-42

PDF download INFLUENCE OF RESPIRATORY TUBERCULOSIS CHEMOTHERAPY ON THE ABILITY OF NEUTROPHILS TO FORM EXTRACELLULAR TRAPS

ZOLOTOV ALEXANDER N., ORCID ID: 0000-0002-6775-323Х; Cand. sc. med., Senior Researcher at the Central Research Laboratory, Associate Professor at the Department of Pathophysiology, Omsk State Medical University, 12 Lenin str., 644099, Omsk, Russia. E-mail: azolotov@mail.ru

NOVIKOV DMITRIJ G., ORCID ID: 000-0002-4339-2222; Cand. sc. med., Associate Professor, Head of the Central Research Laboratory, Omsk State Medical University, 12 Lenin str., 644099, Omsk, Russia. E-mail: novikov.dm.omsk@gmail.com

DYACHENKO ELENA I., ORCID ID: 0009-0005-3081-3226; Junior Researcher, Biochemistry Research Laboratory, Omsk State Pedagogical University, 14 Tukhachevsky Quay, 644099 Omsk, Russia. E-mail: dyachenko.ea@gkpc.buzoo.ru 

MORDYK ANNA V., ORCID ID: 0000-0001-6196-7256; Dr. sc. med., Professor, Head of the Department of Phthisiology, Phthisiologic surgery and Infectious Diseases of Omsk State Medical University, 12 Lenin str., 644099 Omsk, Russia. E-mail: amordik@mail.ru

ROMANOVA MARIYA А., ORCID ID: 0000-0002-1775-607X; Cand. sc. med., Associate Professor at the Department of Phthisiology, Phthisiologic Surgery and Infectious Diseases, Omsk State Medical University, 12 Lenin str., 644099 Omsk, Russia. E-mail: rmari1@mail.ru

INDUTNY ANTON V., ORCID ID: 0000-0003-1951-5824; Dr. sc. med., Associate Professor, Head of the Department of Clinical Laboratory Diagnostics, including Postgraduate Training Courses, Omsk State Medical University, 15/1 20-let RKKA str., 644001 Omsk, Russia. E-mail: anton@indutny.com

KIRICHENKO NIKOLAJ А., ORCID ID: 0000-0002-8411-0973; Junior Researcher at the Central Research Laboratory, Omsk State Medical University, 15/1 20-let RKKA str., 644001 Omsk, Russia. E-mail: honomer_1608@mail.ru

HOLODENKO ALEXANDER О., ORCID ID: 0000-0002-2830-161Х; Postgraduate Student at the Department of Phthisiology, Phthisiologic Surgery and Infectious Diseases, Omsk State Medical University, 12 Lenin str., 644099 Omsk, Russia. E-mail: ptuhin.aleksandr@gmail.com

PERESKOK ALEKSEJ V., ORCID ID: 0009-0009-7622-7627; Assistant Professor at the Department of Clinical Laboratory Diagnostics, including Postgraduate Training Courses, Omsk State Medical University, Researcher at the Central Research Laboratory, Omsk State Medical University, 15/1 20-let RKKA str., 644001 Omsk, Russia. E-mail: alexey.pereskok@gmail.com

Abstracts. Introduction. Neutrophil extracellular traps (NETs) are essential in the pathogenesis of tuberculosis infection, but the influence of antituberculosis chemotherapy on their formation remains unexplored. Aim. The aim of the study was to analyze the effect of respiratory tuberculosis chemotherapy on the ability of neutrophils to form extracellular traps. Materials and Methods. The ability of neutrophils to form extracellular traps after being exposed to a nonspecific antigenic stimulant was studied. The study included 51 healthy children (Control Group) and 21 children with respiratory tuberculosis (TB Group). In the “TB (point 1)” subgroup, all studies were performed at the first-time TB diagnosis, while in the “TB (point 2)” subgroup, they were conducted 6 months after the start of tuberculosis chemotherapy. Results and Discussion. In the children of the “TB (point 1)” subgroup, the percentage of early NETosis cells and the proportion of cloud-shaped and filamentous neutrophil extracellular traps were significantly higher statistically as compared to the “Control” group (p=0.0112, p=0.0041 and p=0.0093, respectively). Six months after the start of antituberculosis chemotherapy, the ability of neutrophils to form extracellular traps changed: In the “TB (point 2)” subgroup, the proportion of early NETosis cells decreased, only one child had cloud-shaped neutrophil extracellular traps – the other children did not form cloud-shaped neutrophil extracellular traps, while the percentage of filamentous neutrophil extracellular traps was not significantly different between the groups (p>0.05). Conclusions. Thus, after tuberculosis chemotherapy, there is a preferential decrease in the percentage of cloud-shaped neutrophil extracellular traps and early NETosis cells.

Keywords: children, tuberculosis infection, chemotherapy, NETosis, neutrophil extracellular traps, ability of neutrophils to form NETs.

For reference: Zolotov AN, Novikov DG, Dyachenko EI, et al. Influence of respiratory tuberculosis chemotherapy on the ability of neutrophils to form extracellular traps. The Bulletin of Contemporary Clinical Medicine. 2024; 17 (6): 37-42. DOI: 10.20969/VSKM.2024.17(6).37-42.

REFERENCES

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6. Новиков Д.Г., Золотов А.Н., Кириченко Н.А., Мордык А.В. Патент No 2768152 C1 Российская Федерация, МПК G01N 33/569, G01N 33/533, G01N 33/577. Способ обнаружения нейтрофильных внеклеточных ловушек в суправитально окрашенном препарате крови: No 2021129097: заявл. 06.10.2021: опубл. 23.03.2022 / заявитель ФГБОУ ВО «Омский государственный медицинский университет» Минздрава России. – 20 c. [Novikov DG, Zolotov AN, Kirichenko NA, Mordyk AV. Patent No 2768152 C1 Rossiyskaya Federatsiya, MPK G01N 33/569, G01N 33/533, G01N 33/577: Sposob obnaruzheniya neytrofil’nykh vnekletochnykh lovushek v supravital’no okrashennom preparate krovi: No 2021129097 : zayavleniye 06 oktyabrya 2021 : opublikovano 23 marta 2022 [Patent No 2768152 C1 Russian Federation, IPC G01N 33/569, G01N 33/533, G01N 33/577: Method for detecting neutrophil extracellular traps in a supravitally stained blood preparation : No. 2021129097 : application 06 October 2021 : published 23 March 2022]. Omskiy gosudarstvennyy meditsinskiy universitet [Omsk State Medical University]. 2022; 20 p. (in Russ.)].

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11. Duan Z, Xie T, Chu C, et al. De-escalation antibiotic therapy alleviates organ injury through modulation of NETs formation during sepsis. Cell Death Discov. 2021; 7 (1): 345. DOI: 10.1038/s41420-021-00745-0

 

 

УДК 616-006-082:614.21:332.012.322

DOI: 10.20969/VSKM.2024.17(6).43-48

PDF download ROUTING PLAN FOR PATIENTS WITH MALIGNANT NEOPLASMS IN A PRIVATE MEDICAL ORGANIZATION

MINAEVA ANNA K., ORCID ID: 0009-0005-3073-3453, Chief Physician of the Polyclinic on Zeleny Prospekt of JSC Medsi Group of Companies, 7 Zeleny Ave., 111141 Moscow, Russia. Tel.: +7(965)244-44-06. E-mail: minaeva.ak@medsigroup.ru

LISAEV DMITRY A., ORCID ID: 0009-0009-4371-9756, Chief Specialist for the Oncology Project at JSC Medsi Group
of Companies, 3A Gruzinsky lane, 111141 Moscow, Russia. Tel.: +7(965)207-13-12. E-mail: lisaev.da@medsigroup.ru

KONOVALOV OLEG E., ORCID ID: 0000-0003-1974-9882; Scopus Author ID 7006781195; SPIN: 5181-8547, Author ID: 250753, Dr. sc. med., Professor at the Department of Public Health, Healthcare and Hygiene, Medical Institute, Peoples’ Friendship University of Russia (RUDN University); 10 Miklouho-Maclay str., Bldg. 2, 117198 Moscow, Russia. Tel.: +7(910)508-10-45. E-mail: konovalov_oe@mail.ru

SHULAEV ALEKSEY V., ORCID ID: 0000-0002-2073-2538; Scopus Author ID 57204471176, SPIN: 3229-1913, Author ID: 210271, Dr. sc. med., Professor, Vice-Rector, Head of the Department of General Hygiene, Kazan State Medical University, 49 Butlerov str., 420012 Kazan, Russia. Tel.: +7(987)213-67-12. E-mail: alexs_shu@mail.ru

PAK VITALY I., ORCID ID: 0000-0002-6941-9745; Cand. sc. med., Assistant Professor, Department of Public Health, Healthcare and Hygiene, Medical Institute, Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN), 10 Miklouho-Maclay str., Bldg. 2, 117198 Moscow, Russia; N.A. Semashko National Research Institute of Public Health, 12 Vorontsovo Pole str., Bldg. 1, Moscow, Russia. Tel.: +7(916)056-56-92. E-mail: pakvan@bk.ru

Abstract. Introduction. Key factors affecting the quality and timeliness of detecting malignant diseases, as well as the prognosis of the disease, are the correctly performed early diagnostics and correct approach to patient routing. Aim. To analyze the algorithm for routing patients with malignant neoplasms, exemplified by a large private medical organization. Materials and Methods. A sociological survey of 412 oncologists, surgeons, proctologists and obstetricians/gynecologists employed in the clinics of JSC Medsi Group of Companies in Moscow and the Moscow Region was conducted using a specially developed questionnaire. Sociological, analytical, and mathematical-statistical research methods were used for the study. Results and Discussion. According to the survey outcomes, 72.7% of the doctors surveyed were informed about the further routing of patients with newly diagnosed malignant neoplasms, who left the contour of JSC Medsi Group of Companies. At the same time, a similar ratio was noted regardless of the special fields of the respondents. The frequency of positive responses in general also did not depend on the respondents’ work experience. At the same time, only 38.3% of doctors had feedback with patients with malignant neoplasms who left the contour of JSC Medsi Group of Companies. It was found that, in the respondents’ opinion, the chief specialist for the Oncology Project, senior oncologist of the medical group, or heads of departments could effectively control the route of a patient with a malignant neoplasm when they leave the contour of this medical organization. JSC Medsi Group of Companies has developed and implemented an effective plan (algorithm) for routing patients with suspected malignant neoplasms. When the malignant neoplasm diagnosis is morphologically confirmed in a patient, this information is automatically displayed on the oncology desktop and sent to the work e-mail of the doctor who has performed the biopsy, as well as of the head of the relevant department. When a patient moves to each of the subsequent stages of treatment or refuses to continue treatment, it is recorded on the oncology desktop of the Medialog MIS, which minimizes the likelihood of losing control over the route of the patient with a malignant neoplasm. Conclusions. Implementing the task of monitoring the correctness of routing a patient with a malignant neoplasm outside the scope of JSC GC Medsi will allow each patient with suspected oncological pathology and with an established diagnosis to timely receive medical care.

Keywords: malignant neoplasms, patients, private organization, routing

For reference: Minaeva AK, Lisaev DA, Konovalov OE, et al. Routing plan for patients with malignant neoplasms in a private medical organization. The Bulletin of Contemporary Clinical Medicine. 2024; 17 (6): 43-48. DOI: 10.20969/VSKM.2024.17(6).43-48.

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  6. Доронина О.В., Брынза Н.С., Кононыхин А.А., Курмангулов А.А. Инструменты совершенствования системы раннего выявления онкологических заболеваний с позиции бережливого производства // Вестник Ивановской медицинской академии. – 2021. – Т. 26, No 3. – С.11-17. [Doronina OV, Bry`nza NS, Konony`xin AA, Kurmangulov AA. Instrumenty` sovershenstvovaniya sistemy` rannego vy`yavleniya onkologicheskix zabolevanij s pozicii berezhlivogo proizvodstva [Tools for improving the system of early detection of oncological diseases from the perspective of lean manufacturing]. Vestnik Ivanovskoj medicinskoj akademii [Bulletin of the Ivanovo Medical Academy]. 2021; 26 (3): 11-17. (In Russ.)].
  7. Алехин С.Г. Оценка эффективности внедрения нового алгоритма маршрутизации пациентов с подозрением на злокачественные новообразования в городской поликлинике г. Москвы // Бюллетень Национального НИИ общественного здоровья имени Н.А. Семашко. – 2022. – No 3. – С.4-10. [Alexin SG. Ocenka e`ffektivnosti vnedreniya novogo algoritma marshrutizacii pacientov s podozreniem na zlokachestvenny`e novoobrazovaniya v gorodskoj poliklinike g. Moskvy` [Evaluation of the effectiveness of the implementation of a new algorithm for routing patients with suspected malignant neoplasms in a city polyclinic in Moscow]. Byulleten` Nacional`nogo NII obshhestvennogo zdorov`ya imeni NA Semashko [Bulletin of the National Research Institute of Public Health named after NA Semashko.]. 2022; 3: 4-10. (In Russ.)]. DOI: 10.25742/NRIPH.2022.03.001
  8. Приказ Министерства здравоохранения РФ от 19 февраля 2021 г. N 116н «Об утверждении Порядка оказания медицинской помощи взрослому населению при онкологических заболеваниях. [Prikaz Ministerstva zdravooxraneniya RF ot 19 fevralya 2021 goda No 116n «Ob utverzhdenii Poryadka okazaniya medicinskoj pomoshhi vzroslomu naseleniyu pri onkologicheskix zabolevaniyax» [Order of the Ministry of Health of the Russian Federation dated February 19, 2021 No 116n «On approval of the Procedure for providing medical care to the adult population with oncological diseases»]. 2021. (In Russ.)]. Режим доступа [URL]: https://base.garant. ru/400533605/
  9. Немкевич Е.Г. Эффективность скрининга и ранней диагностики злокачественных новообразований: экономический аспект // Экономическая наука сегодня. – 2023. – Вып. 17. – С.162–167. [Nemkevich EG. E`ffektivnost` skrininga i rannej diagnostiki zlokachestvenny`x novoobrazovanij: e`konomicheskij aspect [Efficiency of screening and early diagnosis of malignant neoplasms: economic aspect]. E`konomicheskaya nauka segodnya [Economic Science Today]. 2023; 17: 162–167. (In Russ.)]. DOI: 10.21122/2309-6667-2023-17-162-167
  10. Кошкаров А.А., Мурашко Р.А., Елишев В.Г., [и др.] Особенности распределенного хранения медицинских изображений в онкологической службе в рамках создания единого цифрового контура // Врач и информационные технологии. – 2020. – No1. – С.15-27. [Koshkarov AA, Murashko RA, Elishev VG, et al. Osobennosti raspredelennogo xraneniya medicinskix izobrazhenij v onkologicheskoj sluzhbe v ramkax sozdaniya edinogo cifrovogo kontura [Features of distributed storage of medical images in the oncology service within the framework of creating a single digital circuit]. Vrach i informacionny`e texnologii [Doctor and information technology]. 2020; 1: 15-27. (In Russ.)].

  11. Минаева А.К., Лисаев Д.А., Коновалов О.Е., Пак В.И. К вопросу о маршрутизации пациентов с впервые выявленными злокачественными новообразованиями // Вестник Медицинского стоматологического института. – 2023. – No 4. – С.37-39. [Minaeva AK, Lisaev DA, Konovalov OE, Pak VI. K voprosu o marshrutizacii pacientov s vpervy`e vy`yavlenny`mi zlokachestvenny`mi novoobrazovaniyami [On the issue of routing patients with newly diagnosed malignant neoplasms]. Vestnik Medicinskogo stomatologicheskogo instituta [Bulletin of the Medical Dental Institute]. 2023; 4: 37-39. (In Russ.)].

 

 

УДК: 612.085.1; 616-073.584; 616-085

DOI: 10.20969/VSKM.2024.17(6).49-55

PDF download EFFECT PROVIDED BY INHALED SALBUTAMOL ON EXHALED BREATH SIGNATURES IN ADULT PATIENTS WITH CYSTIC FIBROSIS

MUSTAFINA MALIKA KH. ORCID ID: 0000-0002-0250-9949; Cand. sc. med., Associate Professor at the Cardiology Department, I.M. Sechenov First Moscow State Medical University (Sechenov University); Senior Researcher,
Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; 8-2 Trubetskaya str.,119991 Moscow, Russia. E-mail: mustafina_m_kh@staff.sechenov.ru

KRASOVSKY STANISLAV A. ORCID ID: 0000-0001-9642-0947; Cand. sc. med., Senior Researcher, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia, 28 Orekhoviy Boulevard, 115682 Moscow, Russia. E-mail: sa_krasovsky@mail.ru

SILANTYEV ARTEMIY S. ORCID ID: 0000-0001-8360-1415; Researcher, World-Class Research Center – Digital Biodesign and Personalized Healthcare, I.M. Sechenov First Moscow State Medical University (Sechenov University),
8-2 Trubetskaya str., 119991 Moscow, Russia. E-mail: artsilan@gmail.com

SUVOROV ALEKSANDR YU. ORCID ID: 0000-0002-2224-0019; Cand. sc. med., Researcher, World-Class Research Center – Digital Biodesign and Personalized Healthcare, I.M. Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya str., 119991 Moscow, Russia. E-mail: suvorov_a_yu_1@staff.sechenov.ru

KOPYLOV PHILIPP YU. ORCID ID: 0000-0002-4535-8685; Dr. sc. med., Professor, Director, World-Class Research Center – Digital Biodesign and Personalized Healthcare, I.M. Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya str. 119991 Moscow, Russia. E-mail: kopylov_f_yu@staff.sechenov.ru

Abstract. Introduction. Inhalers are often prescribed for patients with cystic fibrosis and the impaired ventilation function of the lungs. Volatile organic compounds in exhaled breath reflect changes in body chemistry and may be useful for monitoring the drug pharmacokinetics and pharmacodynamics. Aim. The aim of our study was to identify the differences in the volatile organic compounds in breath profiles before and 20 minutes after the inhalation of 400 μg of salbutamol in cystic fibrosis adults, using the proton-transfer-reaction time-of-flight mass spectrometry. Materials and Methods. Breath samples were collected from 96 adult patients with cystic fibrosis (50 males and 46 females, mean age 25.8±7.3 yrs) at baseline and 20 minutes after inhalation of 400 μg of salbutamol by proton-transfer-reaction time-of-flight mass spectrometry. Volatile organic compound profiles were listed as ions with various mass-to-charge ratios (m/z). Results and Discussion. 167 features in exhaled breath were detected in cystic fibrosis adults using proton mass spectrometry. Exhaled breath samples before and after 400 μg salbutamol inhalation differed in 76 volatile organic compounds concentrations (p<0.01). Representation of the following volatile organic compounds increased most significantly: m/z = 42.03 (acetonitrile), m/z = 44.04 (C2H5NH+) by percentage change 93.8% and 53.8%, respectively (p<0.001). In turn, the representation of m/z = 71.06, m/z = 181.01 (p-xylene) and m/z = 89.05 (acetoin) decreased most significantly at the percentage changes by 26.1%, 23.4%, and 23.0%, respectively (p<0.001). Conclusions. Our results demonstrate the effect of salbutamol on the composition of exhaled breath metabolites, which should be taken into account when collecting samples in subsequent studies. In addition, proton mass spectrometry could be a useful tool for non-invasive therapeutic drug monitoring.

Keywords: salbutamol; cystic fibrosis; breath analysis; proton mass spectrometry; volatile organic compounds.

For reference: Mustafina MKh, Krasovsky SA, Silantyev AS, et al. Effect provided by inhaled salbutamol on exhaled breath signatures in adult patients with cystic fibrosis. The Bulletin of Contemporary Clinical Medicine. 2024; 17 (6): 49-55. DOI: 10.20969/VSKM.2024.17(6).49-55.

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УДК 616.517.8:577.12(571.17)

DOI: 10.20969/VSKM.2024.17(6).56-64

PDF download IMMUNOGENETIC CHARACTERISTICS OF THE CLINICAL COURSE OF PSORIASIS VULGARIS IN THE INHABITANTS OF KEMEROVO REGION

ROMANOVA ELIZAVETA L., ORCID ID: 0009-0001-3043-434X; Postgraduate Student at the Department of Genetics and Fundamental Medicine, Kemerovo State University, 6 Krasnaya str., 650000 Kemerovo, Russia. E-mail: Rom11elizaveta@yandex.ru

SHABALDIN ANDREY V., ORCID ID: 0000-0002-8785-7896; Dr. sc. med, Associate Professor, Professor, Department of Genetics and Fundamental Medicine, Kemerovo State University, 6 Krasnaya str., 650000, Kemerovo, Russia. E-mail: weit2007@yandex.ru

BELOV YEVGENIY G., ORCID ID: 0009-0003-7582-6229; Chief Physician, Kuzbass Clinical Skin and Venereological Dispensary, 42 Rukavishnikova str., 650025 Kemerovo, Russia. E-mail: epid1720@mail.ru

STRIGA LARISA V., ORCID ID: 0009-00015453-6252; Cand. sc. med., Chief Medical Officer, Kuzbass Clinical Skin and Venereological Dispensary, 42 Rukavishnikova str., 650025 Kemerovo, Russia. E-mail: epid1720@mail.ru

YAKOVLEVA ANASTASIA A., ORCID ID: 0000-0002-6987-8247; Engineer at the Department of Genetics and Fundamental Medicine, Kemerovo State University, 6 Krasnaya str., 650000 Kemerovo, Russia. E-mail: asua-kemerovo2012@ yandex.ru

SHEVCHENKO ELENA A., ORCID ID: 0009-0009-1702-2912; Head of the Mycology Department No. 1, Kuzbass Clinical Skin and Venereological Dispensary, 3A Lyadova str., 650002 Kemerovo, Russia. E-mail: e-shevche@rambler.ru

SHABALDINA ELENA V., ORCID ID: 0000-0002-0450-2767; Dr. sc. med, Chief Physician of Modern Medical Technologies LLC, 11 Sovetsky Ave., 650000 Kemerovo, Russia. E-mail: weit2007@yandex.ru

Abstracts. Introduction. Psoriasis pathogenesis is associated with determination through cytokine genes and with the immune imbalance of innate and adaptive immunity determining psoriatic inflammation. Aim. To study the clinical course features of psoriasis in the inhabitants of Kemerovo region, taking into account immunogenetic markers, i. e., levels of immunoglobulins (A, G, and E), lymphocyte subpopulations (CD4, CD8, CD16/56, and CD19), C-reactive protein, and associations of gene polymorphisms (IL1b rs16944, TNFa rs361525, IL10 rs1800896, IL8 rs2227306, IL6 rs1554606, and CRP rs1205). Materials and Methods. The study included patients with clinically confirmed diagnosis: Psoriasis vulgaris (170 patients) and conditionally healthy individuals (155 patients). Molecular-genetic, clinical-laboratory and biochemical research methods were used. Regression analysis was used to evaluate intergenic and gene-immune interactions in determining psoriasis. Results and Discussion. Psoriasis vulgaris severity (according to PASI score) was associated with statistically significant predictors, i. e., minor (mutant) allele T of the polymorphic region of IL8 gene rs2227306, erythrocyte sedimentation rate, serum immunoglobulin E concentration, and the relative content of CD3+ and CD8+ lymphocytes in peripheral blood. A significant psoriasis severity protector has been identified: Relative content of CD16/56 and CD19+ lymphocytes in peripheral blood. Frequent exacerbations of psoriasis (more than 2 times a year) are largely associated with the predictive role of alpha 2 globulin fraction concentrations and the protective role of total leukocyte levels. Relative levels of CD19+ lymphocytes make a significant protective contribution to the formation of psoriatic arthropathies. Conclusions. Skin lesions and the severity of psoriasis main symptoms are due to high humoral inflammatory activity and imbalance of the cellular immunity link and B-lymphocytes in determining high chemotaxis through a polymorphic variant of the IL8 rs2227306 gene. The risk of frequent psoriasis exacerbations (exceeding 2 times a year) is associated with high concentration of alpha 2 globulin fraction and low leukocyte count in peripheral blood. Psoriatic arthropathy is not determined through the polymorphic gene variants studied and considerably depends on the phenotypic response characteristics of adaptive (B-lymphocytes) immunity

Keywords. Psoriasis, immunoglobulins, lymphocyte subpopulations, C-reactive protein, gene polymorphism.

For reference: Romanova EL, Shabaldin AV, Belov EG, et al. Immunogenetic characteristics of the clinical course of psoriasis vulgaris in the inhabitants of Kemerovo region. The Bulletin of Contemporary Clinical Medicine. 2024; 17 (6): 56-64. DOI: 10.20969/VSKM.2024.17(6).56-64.

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    22. Cui YX, Zhao H, Guo HQ. Role of IL-8 rs4073 and rs2227306 polymorphisms in the development of primary gouty arthritis in a Chinese population. Genet Mol Res. 2016; 15 (4): 1-7. DOI: 10.4238/gmr15048511

    23. Al-Saba AH, Shemran K A, Al-Hattab MK. Study of serum chitinase-3-like-1 protein (CHI3L1) and C-reactive protein (CRP) in patients suffering from chronic plaque psoriasis. Medical Journal of Babylon. 2022: 19(4): 729-735.

    24. Çelik Ş, Nahide Onsun N, Çakıter AU, et al. The Relationship Between C-Reactive Protein Level, Disease Severity and Psoriatic Arthritis in Psoriasis Patients. Phnx Med J. 2020; 2 (2): 79-84. DOI: 10.38175/phnx.658728

    25. Wang S, Xie Z, Shen Z. Serum procalcitonin and C-reactive protein in the evaluation of bacterial infection in generalized pustular psoriasis. An Bras Dermatol. 2019; 94 (5): 542-548. DOI: 10.1016/j.abd.2019.09.022.

    26. Sudhesan A, Rajappa M, Chandrashekar L, et al. Association of C-Reactive Protein (rs1205) Gene Polymorphism with Susceptibility to Psoriasis in South Indian Tamils. J Clin Diagn Res. 2016; 10 (10): GC01 - GC04. DOI:10.7860/JCDR/2016/23391.8624

  

УДК: 616-092.12-091.5

DOI: 10.20969/VSKM.2024.17(6).65-70

PDF download MORPHOLOGICAL PICTURE OF ACUTE KIDNEY INJURY IN YOUNG CHILDREN AFTER CARDIAC SURGERY

KHAYDAROV ALISHER E., ORCID ID: 0009-0002-5903-8786, Cand. sc. med., Head of the Department of Cardiac Anesthesiology, Cardiac Resuscitation and Artificial Circulation, Republican Specialized Scientific and Practical Center of Surgery named after Academician V. Vakhidov, 10 Kichik Khalka Yuli str., Tashkent, Uzbekistan; Assistant Professor at the Department of Surgery and Transplantology, Tashkent State Dental Institute, 103 Makhtumkuli str., Tashkent, Uzbekistan. E-mail: akhaydarov@mail.ru

MARDONOV JAMSHD N., ORCID ID: 0000-0002-0673-5265, Cand. sc. med., Head of the Department of Pathological Anatomy, Republican Specialized Scientific and Practical Center of Surgery named after Academician V. Vakhidov,
10 Kichik Khalka Yuli str., Tashkent, Uzbekistan; Associate Professor at the Department of Surgery and Transplantology, Tashkent State Dental Institute, 103 Makhtumkuli str., Tashkent, Uzbekistan. E-mail: doctor_jamshid@inbox.ru 

SOBIROV DONIYOR M., ORCID ID: 0009-0005-4903-7538, Applicant for the degree of Cand. sc. med., Employee at the Department of Cardiac Anesthesiology, Cardiac Resuscitation and Artificial Circulation, Republican Specialized Scientific and Practical Center of Surgery named after Academician V. Vakhidov, 10 Kichik Khalka Yuli str., Tashkent, Uzbekistan. E-mail: doniyorsm70@gmail.com

KHALIKULOV KHUSAN G., ORCID ID: 0000-0001-7075-8798, Cand. sc. med, Senior Researcher at the Department of Ischemic Heart Disease and Its Complications, Republican Specialized Scientific and Practical Center of Surgery named after Academician V. Vakhidov, 10 Kichik Khalka Yuli str., Tashkent, Uzbekistan. Associate Professor, Department of Surgery and Transplantology, Tashkent State Dental Institute, 103 Makhtumkuli str., Tashkent, Uzbekistan. E-mail: hg27@mail.ru

IRMATOV SARVAR KH., ORCID ID: 0000-0003-3023-4038, Dr. sc. med, Head of the Blood Transfusion Department, Republican Specialized Scientific and Practical Center for Surgery named after Academician V. Vakhidov,
10 Kichik Khalka Yuli str., Tashkent, Uzbekistan. E-mail: ih_sarvarbek@mail.ru

Abstract. Introduction. The most common complication in young children after cardiac surgery is perioperative acute kidney injury. This condition is associated with a high mortality risk and significant morphological changes in the kidneys, which require complex and timely treatment. Aim: To improve the outcomes of combined postoperative treatment in young children with acute kidney injury by assessing the morpho-functional structures of the kidneys, as well as the effectiveness of early peritoneal dialysis. Materials and Methods: Clinical and anatomical analysis was performed on the material of 23 young children who died after cardiac surgery that had included correction of congenital heart defects. Morphological studies included investigation of their medical histories, post-mortem examinations, and histological examinations of renal tissues. Results and Discussion. Hemodynamic disturbances were recorded on the 1st and 2nd days after surgery, including a decrease in hourly diuresis and an increase in serum creatinine levels. The main morphological changes included necrosis of convoluted tubule nephrocytes in 48.6% of cases and dystrophic changes in 51.3% of cases, which was accompanied by multiple organ failure. Conclusions. After the use of cardiotropic and nephroprotective therapy, including early peritoneal dialysis, some children showed restoration of nephrons with the formation of cellular cylinders and fixation of osmolar dialysate in the loop of Henle.

Keywords: acute kidney injury, young children, cardiac surgery, morphological changes, peritoneal dialysis.

For reference: Khaydarov AE, Mardonov JN, Sobirov DM, et al. Morphological picture of acute kidney injury in young children after cardiac surgery. The Bulletin of Contemporary Clinical Medicine. 2024; 17 (6): 65-70. DOI: 10.20969/VSKM.2024.17(6).65-70.

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  1. Селиверстова А.А., Савенкова Н.Д., Хубулава Г.Г., [и др.]. Острое повреждение почек у новорожденных и детей грудного возраста с врожденными пороками сердца после кардиохирургических вмешательств // Нефрология. – 2017. – No 21 (3). – С.54–60. [Seliverstova AA, Savenkova ND, Khubulava GG, et al. Ostroye povrejdeniye pochek u novorojdennyh b detey grudnogo vozrasta s vrojdennymi porokami serdtsa posle kardiohirurgicheskih vmeshatelstv [Acute kidney injury in newborns and infants with congenital heart defects after cardiac surgery]. Nephrologiya [Nephrology]. 2017; 21 (3): 54–60. (in Russ.)]. DOI: 10.24884/1561–6274–2017–3–54–60

  2. Alam S, Shalini A, Hegde RG, et al. A comparative study of the risk stratification models for pediatric cardiac surgery. Egypt J Crit Care Med. 2018; 6 (1): 58. DOI: 10.1016/j. ejccm.2018.03.001

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  9. Kwiatkowska E, Kwiatkowski S, Dziedziejko V, et al. Renal Microcirculation Injury as the Main Cause of Ischemic Acute Kidney Injury Development. Biology. 2023; 12: 327. DOI: 10.3390/biology12020327

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УДК: 616-089.5-031.83:616.718.4

DOI: 10.20969/VSKM.2024.17(6).71-77

PDF download EFFECTIVENESS OF PERICAPSULAR NERVE GROUP BLOCK IN PROXIMAL FEMORAL FRACTURES

SHARIPOVA VISOLATKHON H., ORCID ID: 0000-0003-2517-1183; Dr. sc. med., Professor, Head of the Department of Anesthesiology and Intensive Care, Republican Research Center of Emergency Medicine, , 2 Farkhad str., 100107 Tashkent, Uzbekistan. E-mail: visolat78@mail.ru

ABDULKHAMIDOV ALIBEK A., ORCID ID: 0009-0005-1682-6469; Anesthesiologist and Intensive Care Physician, Department of Anesthesiology and Surgical Intensive Care, Ferghana Branch of the Republican Research Center of Emergency Medicine, 104 Yuksalish str., 100100 Ferghana, Uzbekistan. Tel: +998916591708. E-mail: aliabdulhamidov@bk.ru

ALIMOV AZAMAT H., ORCID ID: 0000-0001-5777-6166; Anesthesiologist and Intensive Care Physician, Head of Neuro, Cardiac and Transplant Surgery ICU, Republican Research Center of Emergency Medicine, 2 Farkhad str., 100107 Tashkent, Uzbekistan. E-mail: azamat.kh.alimov@gmail.com

Abstract. Introduction. Currently, a multimodal approach is used for adequate pain relief, which includes regional analgesia methods in the perioperative pain relief plan, contributing to early activation and reduction of postoperative complications. Aim. Comparison of the effectiveness of pericapsular nerve block and femoral nerve block in patients operated under spinal anesthesia for proximal femur fractures in the perioperative period. Materials and Methods. Depending on the regional analgesia method used, 60 adult patients were randomized into two groups: PENG (n = 30), where pericapsular nerve block was performed, and FNB (n = 30) with femoral nerve block. In the PENG group, pericapsular nerve block was performed under ultrasound navigation with 15-20 ml of 0.5% bupivacaine solution in combination with 4 mg of dexamethasone as an adjuvant to the local anesthetic. In the FNB group, femoral nerve block was performed in a similar manner. The primary endpoint of the study was pain intensity according to a ten-point numeric rating scale during the first day after surgery. Secondary endpoints included consumption of opioid analgesics on the first postoperative day, strength of the anterior thigh muscle groups, angle of a comfortable independent patient’s seat for performing neuraxial anesthesia in the perioperative period, and duration of the block in minutes. Data were analyzed using SPSS software, a p value of <0.05 was taken as statistically significant. Results and Discussion. According to a numeric rating scale, the pain intensity was, on average, 50% lower in the PENG group compared to the FNB group (p<0.05). Blockade of the pericapsular nerve groups caused two times less weakness of the anterior thigh muscle groups, and this made it possible to activate three times more patients in the early postoperative period than with the femoral nerve block. Total opioid analgesic consumption was 40% lower in the PENG group (p < 0.05), potentially reducing their side effects. When positioning patients, 27 patients in the PENG group completed it, which was 90%, and 16 patients (53.3%) in the FNB group; this was almost 37% lower than in the PENG group. The duration of the pericapsular nerve block action was 40% longer than that of the femoral nerve block. Conclusions. Pericapsular nerve block significantly reduces pain, provides less need for opiates, and causes less anterior muscle weakness than femoral nerve blocks, which promotes early mobilization of patients with proximal femoral fractures.

Keywords: proximal femoral fracture, perioperative analgesia, regional anesthesia, pericapsular nerve group block.

For reference: Sharipova VH, Abdulkhamidov AA, Alimov AH. Effectiveness of Pericapsular Nerve Group Block in Proximal Femoral Fractures. The Bulletin of Contemporary Clinical Medicine. 2024; 17 (6): 71-77. DOI: 10.20969/VSKM.2024.17(6).71-77.

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REVIEWS

УДК: 616.831.71-007-073.756.8:616.714.35-089.873

DOI: 10.20969/VSKM.2024.17(6).78-83

PDF download HEADACHES IN CHIARI MALFORMATION

SAKOVETS TATYANA G., ORCID ID: 0000-0002-0713-9836; Scopus Author ID: 35300646500; Web of Science Researcher ID: GXV-6528-2022; Cand. sc. med., Associate Professor at the Department of Neurology, Kazan State Medical University, 49 Butlerov str., 420012 Kazan, Russia. E-mail: tsakovets@yandex.ru

BOGDANOV ENVER I., ORCID ID: 0000-0003-1050-9081. Scopus Author ID:276535; Web of Science Researcher ID: AAV-1365-2021; Dr. sc. med., Professor, Head of the Department of Neurology, Kazan State Medical University, 49 Butlerov str., 420012 Kazan, Russia. E-mail: enver_bogdanov@mail.ru

Abstract. Introduction. Chiari malformation type 1 is found incidentally in 0.7-1% of children and adolescents undergoing magnetic resonance imaging of the brain and spine, and in 0.5% of cases in the adult population. The most common posterior fossa condition associated with cough headaches is Chiari malformation type 1. This condition results from a mesodermal defect, leading to a disparity between the sizes of the posterior cranial fossa and the neural structures it contains. According to the latest international classification of headaches, established by the Committee of the International Headache Society, cough headaches are categorized into primary and secondary (symptomatic) types. Primary cough headaches typically have a benign course. In contrast, symptomatic cough headaches are associated with pathological changes in the bone structure of the posterior cranial fossa and its contents, particularly seen in Chiari malformation type 1. Aim: To identify the characteristics of headaches in Chiari malformation. Materials and Methods. Literature analysis was conducted using international databases, such as Web of Science, Scopus, and PubMed, as well as the domestic library system eLibrary. Results and Discussion. Headaches, along with hydrosyringomyelia, are considered an indication for neurosurgical intervention. However, if we look at headaches as the sole reason for surgery, we must consider their origin. In cases of Chiari malformation, headaches may be linked to migraine or other primary headache types due to their common occurrence. Cough and stress headaches are specific indicators of Chiari malformation. In some instances, Chiari malformation type 1 characterized by dislocation of the cerebellar tonsils, may be a secondary phenomenon resulting from fluctuations in intracranial pressure. This condition can also cause headaches that stem from the secondary dislocation of the cerebellar tonsils. Consequently, the question of whether the dislocation of the cerebellar tonsils, accompanied by headaches, is primary or secondary is particularly relevant. Conclusions. Chiari malformation type 1 is associated with headaches of various types, which can sometimes be challenging for distinguishing them from primary headaches. This necessitates mandatory neuroimaging and careful differential diagnosis by neurologists.

Keywords: chiari malformation, clinical manifestations, treatment.

For reference: Sakovets TG, Bogdanov EI. Headaches in Chiari malformation. The Bulletin of Contemporary Clinical Medicine. 2024; 17 (6): 78-83. DOI: 10.20969/VSKM.2024.17(6).78-83.

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УДК: 616.127-005.4-073.756.8

DOI: 10.20969/VSKM.2024.17(6).84-96

PDF download COMORBIDITY AS A FACTOR OF GASTRODUODENAL ULCER DEVELOPMENT IN ELDERLY AND SENILE PATIENTS

SAKHABETDINOVA KAMILIA N., ORCID ID: 0009-0004-7109-4275; 5th-year student at the Faculty of General Medicine, Kazan State Medical University, 49 Butlerov str., 420012 Kazan, Russia. Tel.: +7 (917) 927-01-19.
E-mail: kamilya.erm@mail.ru

SAKHABETDINOV BULAT A., ORCID: 0000-0003-4867-3194; Assistant Professor at the Department of Operative Surgery and Topographic Anatomy, Kazan State Medical University, 49 Butlerov str., 420012 Russia, Kazan, Russia. Tel.: +7 (937) 578-35-98. E-mail: b.sahabet@gmail.com

AMIROV NAIL B., ORCID ID: 0000-0003-0009-9103; SCOPUS Authоr ID: 7005357664; Dr. sc. med., Professor at the Department of Outpatient Medicine and General Medical Practice, Kazan State Medical University, 49 Butlerov str., 420012 Kazan, Russia, Deputy Chief Physician for Research, Medical Unit of the Ministry of Internal Affairs of the Russian Federation in the Republic of Tatarstan, 132 Orenburg Route str., 420059 Kazan, Russia. Tel.: +7 (843) 291–26–76. E–mail: namirov@mail.ru

Abstract. Introduction. Peptic ulcer disease is a chronic recurrent multifactorial disease that takes its course with alternating exacerbations and remissions and is manifested by ulcerative defects in the mucous membrane of the stomach and duodenum, which is based on an imbalance of aggressive and protective factors with a predominance of the former ones. Of particular interest is the comparative characteristics of gastric and duodenal ulcers in the patients of senile and elderly age groups due to their pathogenetic features and singularity of their clinical picture. Aim. The aim of the study was to summarize current data on the impact of comorbid pathology on the course of gastric and duodenal ulcers in elderly and senile patients. Materials and Methods. Current studies were reviewed, published in the eLibrary, Scopus, and PubMed databases in 2014–2024and appearing in Google Scolar, dealing with the etiopathogenetic variants of gastric and duodenal ulcers and comorbidity with various diseases in elderly and senile patients. Results and Discussion. The increase in numbers of patients with peptic ulcer disease among those in the elderly and senile age groups takes place due to the global demographic aging of the population, which leads to an increase in numbers of patients with multiple chronic diseases. In most cases, in elderly and senile patients, peptic ulcers of the stomach and duodenum are not any evidence of a distinct disease entity known as peptic ulcer disease. Among such patients, peptic ulcer is a multifactorial disease of polyetiological origin with many etiopathogenetic variants, including various changes associated with cardiovascular diseases, such as atherosclerosis, coronary heart disease, and chronic heart failure; endocrine pathologies; and concomitant peptic ulcers in the chronic diseases of lungs or kidneys and post-coronavirus metabolic disorders. Of particular interest are the so-called drug-induced ulcers associated with the treatment of a chronic or acute disease and providing an ulcerogenic effect on the stomach and duodenum. Conclusions. Taking into account the data obtained on the etiopathogenetic variants of peptic ulcer disease, the task was set to study the prevalence of gastric and duodenal ulcers among elderly and senile patients with chronic diseases. Timely identification of the comorbid nature of the disease will allow achieving better results in therapy and improve the prognosis of patients with gastric and duodenal ulcers.

Keywords: comorbidity, gastric ulcer, duodenal ulcer, elderly, senile patients.

For reference: Sakhabetdinova KN, Sakhabetdinov BA, Amirov NB. Comorbidity as a factor of gastroduodenal ulcer development in elderly and senile patients. The Bulletin of Contemporary Clinical Medicine. 2024; 17 (6): 84-96. DOI: 10.20969/VSKM.2024.17(6).84-96.

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DOI: 10.20969/VSKM.2024.17(6).97-104

PDF download STAGED LIVER RESECTION USING ALPPS TECHNOLOGY: AN INNOVATIVE SURGICAL TECHNIQUE FOR THE TREATMENT OF MULTIPLE COLORECTAL LIVER METASTASES

ANISIMOV ANDREY YU., ORCID ID: 0000-0003-4156-434X; Scopus Author ID: 57190227316; Researcher ID: B-1467-2019; eLibrary ID: 260429; Dr. sc. med., Professor, Corresponding Member of the Russian Academy of Natural Sciences, Head of the Department of Emergency Aid and Simulation Medicine, Center of Medicine and Pharmacy, Higher School of Medicine, Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, 74 A Karl Marx str., 420012 Kazan, Russia. Tel.: +7 (843) 291-26-76. E-mail: aanisimovbsmp@yandex.ru

МAVLONOV FAYZALY B., ORCID ID: 0009-0008-6321-4168; Cand. sc. med., Clinical Director, National Scientific Center for Transplantation of Human Organs and Tissues at the Ministry of Health and Social Protection
of the Republic of Tajikistan. 2 Mayakovskaya str., 734000 Dushanbe, Republic of Tajikistan. E-mail: faizimavlon@mail.ru

Abstract. Introduction. Postoperative acute liver failure is a life-threatening companion of extensive liver resection in patients with colorectal liver metastases. A surgical technique called Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) has been proposed to induce hyperplasia of the planned liver remnant. Aim. The aim of the study is to analyze our own clinical experience of staged liver resection using the ALPPS technique in the complex surgical treatment of multiple colorectal liver metastases to the liver and compare it with other authors’ results. Materials and Methods. In this clinical observation, two-stage liver resection using the ALPPS technique was successfully used in the complex treatment of a male patient with multiple liver metastases of low-differentiated sigmoid colon adenocarcinoma, stage IIIA (T2N1M0). Upon prior chemotherapy, the planned liver remnant volume was less than 25%. Results and Discussion. Duration of the first stage of surgery was 210 minutes, and intraoperative blood loss was 450 ml. By the eighth day of the postoperative period, the volume of the planned liver remnant increased by 9%, reaching 38%. The second stage of intervention was performed nine days after the first one. Its duration was 75 minutes, and blood loss was 150 ml. On the 16th day after the second stage of the surgery, the patient was discharged from the hospital in satisfactory condition. A control CT scan performed three months after discharge revealed a 54% increase in the liver remnant compared to its initial size and no new metastatic foci. The patient subsequently received adjuvant polychemotherapy. Unfortunately, 31 months after performing the ALPPS surgery, the patient died. The death was caused by cancer recurrence. Conclusions. The presented clinical observation demonstrates the successful and complete completion of extensive bilobar liver resection with achievement of R0-resection in a patient with multiple colorectal liver metastases. Despite the favorable surgical outcome, cancer recurrence was fatal.

Keywords: colorectal liver metastases, surgical treatment, ALPPS, post-hepatectomy liver failure, planned liver remnant.

For reference: Anisimov AY, Mavlonov FB. Staged liver resection using ALPPS technology: An innovative surgical technique for the treatment of multiple colorectal liver metastases. The Bulletin of Contemporary Clinical Medicine. 2024; 17 (6): 97-104. DOI: 10.20969/VSKM.2024.17(6).97-104.

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УДК 616.587-007.24-089

DOI: 10.20969/VSKM.2024.17(6).105-111

PDF download USING CALCULATIONS IN THE RECONSTRUCTIVE SURGERY OF STATIC FOREFOOT DEFORMITY (case report)

LEONOVA SVETLANA N., ORCID ID: 0000-0003-3675-6355; Dr. sc. med., Senior Researcher at Irkutsk Science Centre of Surgery and Traumatology, 1 Bortsov Revolutsii str., 664003 Irkutsk, Russia. Tel. +7-395-229-03-44.
E-mail: svetlana.leonova.1963@mail.ru

USOLTSEV IVAN V., ORCID ID: 0000-0002-4175-8403; Cand. sc. med., Researcher at Irkutsk Science Centre of Surgery and Traumatology, 1 Bortsov Revolutsii str., 664003 Irkutsk, Russia. Tel. +7-395-229-03-44. E-mail: ivu38@mail.ru 

KOSAREVA MARIYA A., ORCID ID: 0000-0003-0530-3409; Junior Researcher at Irkutsk Science Centre of Surgery and Traumatology, 1 Bortsov Revolutsii str., 664003 Irkutsk, Russia. Tel. +7-395-229-03-44. E-mail: mary.good.mary@yandex.ru

VASILEV VAYCHESLAV Y., ORCID ID: 0000-0001-7545-4419; Head of the Department of Traumatology and Orthopedy No. 2, Irkutsk Science Centre of Surgery and Traumatology, 1 Bortsov Revolutsii str., 664003 Irkutsk, Russia.
Tel. +7-395-229-03-44. E-mail: coxa_vara@mail.ru

Abstract. Introduction. Studying the matters of surgically treating various forefoot static deformities and their poor outcomes revealed the shortcomings of correction methods using metatarsal osteotomies, one of which is the lack of preoperative calculations of the necessary reconstruction. The aim is to demonstrate how to use calculations necessary for the forefoot reconstruction, exemplified by treating a female patient with a combination of the first- and second-toe deformities. Materials and Methods. A clinical case is presented demonstrating the successful application of a new surgical technique to correct the second hammer toe combined with hallux valgus, including the exact calculations of the required values of shortening the metatarsal bone and of laterally displacing its head towards the toe deviation. Results and Discussion. In a 63-year-old female patient, based on clinical and X-ray examinations, a mobile hammer toe deformity was determined, accompanied by a lateral toe deviation in the metatarsophalangeal joint and metatarsalgia under the head of the second metatarsal bone, and a deformity of the first toe, i.e., hallux valgus. Surgery was recommended and performed. To correct the first toe deformation, the proprietary technology was successfully used. Correction of the second toe deformation included preoperative calculations of the values required for shortening the second metatarsal bone and displacing its head, marking two parallel lines at a distance of the shortening calculated, and performing osteotomies of the second metatarsal at different angles with the removal of a free bone fragment, comparison of distal and proximal fragments, lateral displacement of the metatarsal head, and screw fixation. Using accurate preliminary calculations that allow reducing the metatarsal bone length by the required value and laterally shifting its head towards the toe deflection in the metatarsophalangeal joint ensures the correction of the second hammer toe and the release of the toe flexion position in the proximal interphalangeal joint, the toe extensor position and external deviation in the metatarsophalangeal joint, and the amelioration of metatarsalgia. Conclusions. Using a new surgical technique for the treatment of the second hammer toe, including calculations and the performance of two osteotomies along the marked lines, allows achieving a good result and a normal ratio of metatarsal lengths, optimally redistributing the loads on the metatarsal heads, eliminating forefoot pain and metatarsalgia manifestations, and preventing from the development of transitional metatarsalgia and deformation recurrence.

Keywords: static forefoot deformity, hammer toe, osteotomy of the metatarsal bone.

For reference: Leonova SN, Usoltsev IV, Kosareva MA, Vasilev VY. Using calculations in the reconstructive surgery of static forefoot deformity (case report). The Bulletin of Contemporary Clinical Medicine. 2024; 17 (6): 105-111. DOI: 10.20969/VSKM.2024.17(6).105-111.

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  19. Способ оперативного лечения метатарзалгии при деформациях переднего отдела стопы: Пат. 2705233, Рос. Федерация; МПК A61B 17/00 / К.А. Егиазарян, Г.В. Коробушкин, Е.А. Мирошникова, Е.А. Жаворонков, А.С. Абилемец; заявитель и патентообладатель Егиазарян Карен Альбертович. – No 2019123644; заявл.26.07.2019; опубл. 06.11.2019. – Бюл. No 31. [Egiazaryan KA, Korobushkin GV, Miroshnikova EA, ZHavoronkov EA, Abilemec AS. Sposob operativnogo lecheniya metatarzalgii pri deformaciyah perednego otdela stopy: patent 2705233 [Method of surgical treatment of metatarsalgia in forefoot deformities: patent 2705233]. Rossiyskaya federatsiya MPK A61V 17/00/; zayavitel’ i patentoobladatel’ Egiazaryan Karen Al’bertovich No 2019123644; zayavleno 2019/07/26; opublikovano 2018/11/06 [Russian Federation MPK A61V 17/00/; the applicant and the patent holder Egiazaryan Karen Al’bertovich; No 2019123644; declared 2019/07/26; published 2018/11/06]. 2018; Bulletin 31. (in Russ.)].

  20. Бобров Д. С., Слиняков Л. Ю., Ригин Н.В. Перегрузочная метатарзалгия: патогенез, биомеханика и хирургическое лечение (аналитический обзор литературы) // Вестник Российской академии медицинских наук. – 2017. – Т. 72, No 1. – С.53–58. [Bobrov DS, Slinyakov LYu, Rigin NV. Peregruzochnaya metatarzalgiya: patogenez, biomekhanika i hirurgicheskoe lechenie (analiticheskij obzor literatury) [Metatarsalgia: pathogenesis, biomechanics and surgical treatment (analytical literature review)]. Vestnik Rossijskoj akademii medicinskih nauk [Annals of the Russian academy of medical sciences]. 2017; 72 (1): 53-58. (In Russ.)]. DOI: 10.15690/vramn756

  21. Леонова С.Н., Усольцев И.В. Способ оперативного лечения вальгусного отклонения первого пальца стопы: медицинская технология. – Иркутск: ИНЦХТ, 2016. – 20 с. [Leonova SN, Usol’cev IV. Sposob operativnogo lecheniya val’gusnogo otkloneniya pervogo pal’ca stopy: medicinskaya tekhnologiya [Method of surgical treatment of hallux valgus: medical technology]. Irkutsk: INCHT [Irkutsk: ISCST]. 2016; 20 p. (In Russ.)].

 

 

УДК: 616.37-007.253

DOI: 10.20969/VSKM.2024.17(6).112-119

PDF download INTERNAL PANCREATIC FISTULA IN A PATIENT WITH ACUTE DESTRUCTIVE PANCREATITIS ASSOCIATED WITH SYSTEMIC CONNECTIVE TISSUE DISEASES

LUKASHEW ANDREW D., ORCID ID: 0000-0002-7049-8786, Radiologist, 2nd–Year Postgraduate Student, Kazan (Volga Region) Federal University, 18 Kremlevskaya str., Bldg. 1, 420008 Kazan, Russia.
E-mail: Andrewlukashew@gmail.com

KUROCHKIN SERGEY V., ORCID ID: 0000-0002-8043-3871, Cand. sc. med., Head of the X-Ray Diagnostic Department – Radiologist, City Clinical Hospital No. 7 named after M.N. Sadykov, 54 Marshala Chuikova str., 420103 Kazan, Russia. E-mail: kurochkin.70@bk.ru

TAGIROV MARAT R., ORCID ID: 0000-0003-1924-7276; Cand. sc. med., Associate Professor at the Department of Surgery, Kazan State Medical Academy, 36 Вutlerov str., 420012 Kazan, Russia; Surgeon, Department
of Surgery No. 2, City Clinical Hospital No. 7 named after M.N. Sadykov, 54 Marshala Chuikova str., 420103 Kazan, Russia. E-mail: tagirov72@yandex.ru

ZAKIROVA ELVIRA B., ORCID ID: 0000-0002-4653-1734; Cand. sc. med., Deputy Chief Physician for Diagnostics, City Clinical Hospital No. 7 named after M.N. Sadykov, 54 Marshala Chuikova str., 420103 Kazan, Russia.
E-mail: frolova.67@mail.ru

MAKAROV DENIS V., ORCID ID: 0000-0003-2246-9849; Endoscopist, Endoscopy Department, City Clinical Hospital No. 7 named after M.N. Sadykov, 54 Marshala Chuikova str., 420103 Kazan, Russia. E-mail: molod4ek@yandex.ru

Abstract. Introduction. A pPancreatic fistula is an abnormal connection of pancreatic ductal epithelium with another epithelial surface. Pancreatic fistulas may occur as a complication of acute or chronic pancreatitis. The incidence of external and internal fistulas in the outcome of pancreatic necrosis ranges from 5 to 50%. Aim was to present for discussion a clinical case of a female patient with acute pancreatitis complicated by pseudocysts and an internal pancreatic fistula, associated with systemic connective tissue diseases, as well as the results of diagnosing and the treatment options chosen. Material and Methods. A patient with a history of acute pancreatitis and connective tissue diseases. The article presents the case history, clinical manifestations, examination findings underlying the concept of patient management, and minimally invasive diagnostic and therapeutic manipulations. Results and Discussion. Diagnostic measures revealed bilateral hydrothorax, pancreatic pseudocysts (including mediastinal localization), and an internal pancreatic fistula. Conservative treatment with minimally invasive interventions was chosen. Conclusions. The clinical case presented illustrates the variability of the late complications of acute pancreatitis; a high therapeutic value of the conservative treatment of the patient in combination with pancreaticoduodenal stenting; great opportunities of multimodal instrumental diagnostic methods in identifying in identifying and precisely localizing the internal pancreatic fistula and assessing the associated pathologies; and the necessity of interrelations across all the diagnostic and clinical services.

Keywords: stenting, computed tomography scan, magnetic resonance imaging, ultrasonography

For reference. Lukashew AD, Kurochkin SV, Tagirov MR, et al. Internal pancreatic fistula in a patient with acute destruc- tive pancreatitis associated with systemic connective tissue diseases. The Bulletin of Contemporary Clinical Medicine. 2024; 17 (6): 112-119. DOI: 10.20969/VSKM.2024.17(6).112-119.

REFERENCES

 

  1. Rodriguez EA, Sussman DA, Rodriguez VR. Systemic lupus erythematosus pancreatitis: an uncommon presentation of a common disease. Am J Case Rep. 2014; 15: 501-503. DOI: 10.12659/AJCR.891281
  2. Abughazaleh S, Alsakarneh S, Hattar M, et al. Systemic Lupus Erythematosus in Disguise: Acute Pancreatitis as Initial Presentation. J Investig Med High Impact Case Rep. 2023; 11: 23247096231185480. DOI: 10.1177/23247096231185480
  3. Бойко Т.В., Брегель Л.В., Матюнова А.Е., [и др.]. Острый панкреатит в сочетании с язвами желудка и гепатитом при системной красной волчанке у подростка 16 лет // Педиатрия им. Г.Н. Сперанского. – 2020. – No 99 (3). – С. 289-294. [Bojko TV, Bregel’ LV, Matyunova AE, et al. Ostryj pankreatit v sochetanii s yazvami zheludka i gepatitom pri sistemnoj krasnoj volchanke u podrostka 16 let [Acute pancreatitis in combination with stomach ulcers and hepatitis in a 16 year old adolescent with systemic lupus erythematosus]. Pediatriya imeni GN Speranskogo [Pediatrics named after GN Speransky.]. 2020; 99 (3): 289-294. (In Russ.)].
  4. Gupta T, Singh A, Chauda R, et al. Acute Pancreatitis: A Rare Presentation of Systemic Lupus Erythematosus. Journal Of Medical Cases. 2017; 8 (4): 105-107.
  5. Unegbu FC, Anjum F. Pancreatic Fistula [Internet]. Treasure Island (FL): StatPearls Publishing. 2024. URL: https://www.ncbi.nlm.nih.gov/books/NBK560871/
  6. Siva Sankar A, O K P, Banu KJ, Pon Chidambaram M. A Single-Center Experience of Internal Pancreatic Fistulas. Cureus. 2022; 14 (9): e29181. DOI: 10.7759/ cureus.29181
  7. Котельникова Л.П., Плаксин С.А., Бурнышев И.Г., Трушников Д.В. Факторы риска формирования наружных и внутренних панкреатических свищей после панкреонекроза // Анналы хирургической гепатологии. – 2021. – No 26 (2). – С. 39-49. [Kotel’nikova LP, Plaksin SA, Burnyshev IG, Trushnikov DV. Faktory riska formirovaniya naruzhnyh i vnutrennih pankreaticheskih svishchej posle pankreonekroza [Predictors for external and internal pancreatic fistulas after pancreatic necrosis]. Annaly hirurgicheskoj gepatologii [Annals of HPB Surgery]. 2021; 26 (2): 39-49. (In Russ.)]. DOI: 10.16931/10.16931/1995-5464.2021-2-39-49
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  9. Котельникова Л.П., Плаксин С.А., Кудрявцев П.Л., Фаршатова Л.И. Лёгочно-плевральные осложнения панкреатита // Вестник хирургии имени И.И. Грекова. – 2017. – No 176 (3). – С.28-31. [Kotel’nikova LP, Plaksin SA, Kudryavcev PL, Farshatova LI. Lyоgocрno-plevral’nye oslozрneniyа pankreatita [Pulmonary-pleural complications of pancreatitis]. Vestnik hirurgii imeni II Grekova [Grekov’s Bulletin of Surgery]. 2017; 176 (3): 28-31. (In Russ.)]. DOI: 10.24884/0042-4625-2017-176-3-28-31
  10. Panyko A, Vician M, Dubovský M, Škubla R. Mediastinal Pancreatic Pseudocyst with Hemoptysis – A Thoracic Complication of Pancreatitis. Cureus. 2020; 12 (11): e11518. DOI: 10.7759/cureus.11518
  11. Будзинский С.А., Шаповальянц С.Г., Федоров Е.Д., Шабрин А.В. Эндоскопическое транспапиллярное панкреатическое стентирование в лечении свищей поджелудочной железы (с комментарием А.Г. Кригера) // Хирургия. Журнал им. Н.И. Пирогова. – 2017. – No 2. – С.32-44. [Budzinskij SA, Shapoval’yanc SG, Fedorov ED, Shabrin AV. Endoskopicheskoe transpapillyarnoe pankreaticheskoe stentirovanie v lechenii svishchej podzheludochnoj zhelezy (s kommentariem AG Krigera) [Endoscopic pancreatic stenting in pancreatic fistulas management (with commentary by AG Krieger)]. Khirurgiya; Zhurnal imeni NI Pirogova [Pirogov Russian Journal of Surgery]. 2017; 2: 32-44. (In Russ.)]. DOI: 10.17116/hirurgia2017232-44

 

УДК 616.587-007.24-089

DOI: 10.20969/VSKM.2024.17(6).120–127

PDF download MOBILE CLAW TOE SYNDROME (CHECKREIN DEFORMITY): a clinical case

USOLTSEV IVAN V., ORCID ID: 0000-0002-4175-8403; Cand. sc. med., Researcher at Irkutsk Science Centre of Surgery and Traumatology, 1 Bortsov Revolutsii str., 664003 Irkutsk, Russia. Tel. +7-395-229-03-44. E-mail: ivu38@mail.ru 

LEONOVA SVETLANA N., ORCID ID: 0000-0003-3675-6355; Dr. sc. med., senior researcher of Irkutsk Science Centre of Surgery and Traumatology, 1 Bortsov Revolutsii str., 664003 Irkutsk, Russia. Tel. +7-395-229-03-44. E-mail: svetlana.leonova.1963@mail.ru

GUBAR ILIYA E., ORCID ID: 0009-0000-8912-3995; PhD Student at Irkutsk Science Centre of Surgery and Traumatology, 1 Bortsov Revolutsii str., 664003 Irkutsk, Russia. Tel. +7-395-229-03-44. E-mail: gybarilya@yandex.ru

VASILEV VAYCHESLAV Y., ORCID ID: 0000-0001-7545-4419; Head of the Department of Traumatology and Orthopedy No. 2, Irkutsk Science Centre of Surgery and Traumatology, Russia, 1 Bortsov Revolutsii str., 664003 Irkutsk, Russia.
Tel. +7-395-229-03-44. E-mail: coxa_vara@mail.ru

Abstract. Introduction. The syndrome of mobile claw toes or, as it is commonly called in the English-language scientific literature, checkrein deformity is a rare dynamic deformity of toes that develops secondary to any traumatic factor at the level of the ankle joint and foot. A special aspect of the clinical example presented is that the pathology developed without any direct impact on the above-mentioned anatomical areas. We have not found any references to  or descriptions of such a clinical observation in the literature available. The aim of the publication was to demonstrate the clinical observation of a patient with the spontaneously developed syndrome of mobile claw toes. Materials and Methods. The article presents the outcomes of the surgical treatment of this pathology in a 52-year-old female patient and evaluates the resulting functional changes using pedobarometric and stabilometric tests. Results and Discussion. A 52-year-old female patient, four months after the planned surgical intervention (augmentation mammoplasty), drew attention to the restriction of movements in the I and II metatarsophalangeal joints in a certain left foot position, which progressed and made it difficult to walk and stand on tiptoes. No preceding injury facts have been established. Conservative treatment did not produce the desired effect. Surgical intervention was performed, which consisted in the release and Z-shaped elongation of the tendons of the long flexor of the first finger and the long flexor of the toes. After the surgery, the operated foot was immobilized for 6 weeks with a posterior plaster splint at an angle of 90 degrees. During the treatment, there were no abnormalities in the patient’s condition or in clinical and laboratory parameters. The stitches were removed on the fourteenth day. Six weeks after the operation, immobilization was discontinued, and walking was allowed with a gradual loading increase. The surgical intervention resulted in the relief of manifestations of the claw toes syndrome and the restoration of foot support, which allowed the patient to return to her usual lifestyle without any restrictions, and the objective criterion of effectiveness was the improvement of basic pedobarometric and stabilometric indicators. Conclusions. The patient treatment outcome obtained regarding the syndrome of mobile claw toes allows us to conclude that surgical treatment is acceptable and encourages further search for the causes of this syndrome and possible options of preventing it.

Keywords: claw toe, checkrein deformity, surgical treatment, pedobarometry.

For reference: Usoltsev IV, Leonova SN, Gubar IE, Vasilev VY. Mobile claw toe syndrome (checkrein deformity): A сlinical case. The Bulletin of Contemporary Clinical Medicine. 2024; 17 (6): 120-127. DOI: 10.20969/VSKM.2024.17(6).120-127.

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  1. Greco T, Cianni L, Polichetti C, et al. Uncoated vs. Antibiotic–Coated Tibia Nail in Open Diaphyseal Tibial Fracture (42 According to AO Classification): A Single Center Experience. Bio Med Res Int. 2021; 2021: 7421582. DOI: 10.1155/2021/7421582

  2. Perisano C, Greco T, Polichetti C, et al. Antibiotic–Coated Nail in Open Tibial Fracture: A Retrospective Case Series. J Funct Morphol Kinesiol. 2021; 6: 97. DOI: 10.3390/ jfmk6040097

  3. Sinnett T, Rudge B, Clark C. A Case of Check–Rein Deformities of the Great and Lesser Toes Treated through Exploration at the Midfoot. Foot Ankle Surg. 2015; 21: e6–e8. DOI: 10.1016/j.fas.2014.08.009

  4. Gadhavi MV, Majmundar DD, Solanki RA. Checkrein Deformity of the Great toe Managed by Midfoot Flexor Hallucis Longus Z–Plasty: A Case Report. J Orthop Case Rep. 2019; 9 (2): 18–20. DOI: 10.13107/ jocr.2250–0685.1350

  5. Rosenberg GA, Sferra JJ. Checkrein Deformity—An Unusual Complication Associated with a Closed Salter– Harris Type II Ankle Fracture: A Case Report. Foot Ankle Int. 1999; 20: 591–594. DOI: 10.1177/107110079902000910

  6. Leitschuh PH, Zimmerman JP, Uhorchak JM, et al. Hallux Flexion Deformity Secondary to Entrapment of the Flexor Hallucis Longus Tendon after Fibular Fracture. Foot Ankle Int. 1995; 16: 232–235. DOI: 10.1177/107110079501600413

  7. Bai L, You T, Zhang W. Checkrein Deformity of the Hallux Caused by Misplaced Suture–Button Syndesmosis Fixation: A Case Report. J Foot Ankle Surg. 2020; 59: 598–602. DOI: 10.1053/j.jfas.2019.09.031

  8. Carr JB. Complications of Calcaneus Fractures Entrapment of the Flexor Hallucis Longus: Report of Two Cases. J Orthop Trauma. 1990; 4: 166–168. DOI: 10.1097/00005131–199004020–00011

  9. Kim SH, Lee KT, Smith RW, Park Y–U. Checkrein Deformity Secondary to Entrapment of FHL after Talus Fracture: A Case Report. Foot Ankle Int. 2010; 31: 336–338. DOI: 10.3113/FAI.2010.0336

  10. Abolfotouh SM, Mahmoud KM, Mekhaimar MM, et al. Checkrein Deformity Associated with Intra–Articular Talar Fracture: A Report of Three Cases. JBJS Case Connect. 2015; 5: e21. DOI: 10.2106/JBJS.CC.N.00024

  11. Tanwar YS, Singh S, Arya RK, et al. A Closed Lateral Subtalar Dislocation with Checkrein Deformity of Great Toe due to Entrapment of Flexor Hallucis Longus: A Case Report. Foot Ankle Spec. 2016; 9: 461–464. DOI: 10.1177/1938640016630060

  12. Sanhudo JAV, Lompa PA. Checkrein Deformity–Flexor Hallucis Tethering: Two Case Reports. Foot Ankle Int. 2002; 23: 799–800. DOI: 10.1177/107110070202300904

  13. Feng X–J, Jiang Y, Wu J–X, Zhou Y. Efficacy of Comprehensive Rehabilitation Therapy for Checkrein Deformity: A Case Report. World J Clin Cases. 2020; 8: 444–450. DOI: 10.12998/wjcc.v8.i2.444

  14. Sallent A, Soza D, Duarri G, Busquets R. Checkrein Deformity: A Case Report of Two Patients with Hallux Deformity and Pain Following Mandibular Reconstruction in Oral Cancer Treatment. Oral Maxillofac Surg. 2020; 24: 359–362. DOI: 10.1007/s10006–020–00852–9

  15. Feeney MS, Williams RL, Stephens MM. Selective Lengthening of the Proximal Flexor Tendon in the Management of Acquired Claw Toes. J Bone Jt Surg Br. 2001; 83: 335–338. DOI: 10.1302/0301–620X.83B3.0830335

  16. Rodriguez–Collell JR, Mifsut–Miedes D. Checkrein Deformity of the Hallux and Second Toe after Soft–Tissue Injury. Case Rep Orthop. 2021; 2021: 8459586. DOI: 10.1155/2021/8459586

  17. Lee JH, Kim YJ, Baek JH, Kim DH. Z–Plasty of the Flexor Hallucis Longus Tendon at Tarsal Tunnel for Checkrein Deformity. J Orthop Surg. 2016; 24: 354–357. DOI: 10.1177/1602400316

  18. Holcomb TM, Temple EW, Barp EA, Smith HL. Surgical Correction of Checkrein Deformity after Malunited Distal Tibia Fracture: A Case Report. J Foot Ankle Surg. 2014; 53: 631–634. DOI: 10.1053/j.jfas.2014.04.028

  19. Yuen CP, Lui TH. Adhesion of Flexor Hallucis Longus at the Site of a Tibial–Shaft Fracture—A Cause of a Checkrein Deformity. Foot Ankle Surg. 2015; 21: e23–e26. DOI: 10.1016/j.fas.2014.09.011

  20. Lee HS, Kim JS. Treatment of Checkrein Deformity of the Hallux. J Bone Jt Surg. 2008; 90: 4. DOI: 10.1302/0301–620X.90B8.20563

  21. Polichetti C, Greco T, Inverso M, et al. Retro–Malleolar Z– Plasty of Flexor Hallucis Longus Tendon in Post–Traumatic Checkrein Deformity: A Case Series and Literature Review. Medicina. 2022; 58 (8): 1072. DOI: 10.3390/ medicina58081072

  22. Chen WT, Liu ZY, Wang BJ. Posttraumatic checkrein deformity following isolated Lauge–Hansen pronation external rotation stage IV malleolar fracture–a case report and literature review. Front Surg. 2023; 10: 887611. DOI: 10.3389/fsurg.2023.887611

  23. Holcomb TM, Temple EW, Barp EA, Smith HL. Surgical correction of checkrein deformity after malunited distal tibia fracture: a case report. J Foot Ankle Surg. 2014; 53 (5): 631–634. DOI: 10.1053/j.jfas.2014.04.028

  24. Скворцов Д.В. Стабилометрическое исследование. – Москва: Маска, 2010. – 176 с. [Skvorcov DV. Stabilometricheskoe issledovanie [Stabilometric stady]. Moskva: Maska [Moskow: Mask]. 2021; 176 p. (In Russ.)].

 

 

ORGANIZATION OF HEALTHCARE

УДК 614.881:616-082.6

DOI: 10.20969/VSKM.2024.17(6).128-133

PDF download MEDICAL AND ORGANIZATIONAL ASPECTS OF OPTIMIZING THE ADMITTING DEPARTMENT ACTIVITIES IN AN EMERGENCY HOSPITAL

BANIN IGOR N., ORCID ID: 0000-0003-2359-9215; Cand. sc. med., Minister of Health of Voronezh Region, 52d Krasnoarmeyskaya str., Voronezh, Russia. Tel.: +7(920)421-23-33. E-mail: banin_igor@mail.ru

KONOVALOV OLEG E., ORCID ID: 0000-0003-1974-9882; Dr. sc. med., Professor at the Department of Public Health, Healthcare and Hygiene, Medical Institute, Patrice Lumumba Peoples’ Friendship University of Russia, 10 Miklouho-Maclay str., Bldg. 2, Moscow, Russia. Tel.: +7(910)508-10-45. E-mail: konovalov_oe@mail.ru

SHULAEV ALEXEY V., ORCID ID: 0000-0002-2073-2538; Dr. sc. med., Professor, Vice-Rector, Head of the Department of General Hygiene, Kazan State Medical University, 49 Butlerov str., Kazan, Russia. Tel.: +7(987)213-67-12.
E-mail: alexs_shu@mail.ru

BREUSOV ALEXEY V., ORCID ID: 0000-0003-2335-3338; Dr. sc. med., Professor at the Department of Public Health, Healthcare and Hygiene, Medical Institute, Patrice Lumumba Peoples’ Friendship University of Russia, 10 Miklouho-Maclay str., Bldg. 2, Moscow, Russia; Head of the Department of Public Health and Healthcare, Institute of Continuing Education with the Educational Center of Lean Technologies, Kursk State Medical University. Russia, 3 K. Marx str., 305041 Kursk, Russia. Tel.: +7(903)511-60-80. E-mail: ab69@yandex.ru

Abstract. Introduction. Public medical care accessibility and quality are strategic objectives of domestic healthcare. Successfully solving these problems is greatly facilitated by the efficient operation of 24-hour hospitals, which largely depends on the quality of the admitting department that significantly impacts the efficiency of the entire hospital. Aim of the study is to optimize the admitting department activities of a multidisciplinary emergency hospital, based on reasonably organized admission of patients, differentiated sorting, and subsequent routing of patients depending on their condition severity. Materials and Methods. The study was carried out based on Voronezh City Clinical Hospital of Emergency Medical Care No. 1, which is a 24-hour multidisciplinary hospital with a capacity of 800 beds. The study was aimed at the main activities of the admitting department of the said hospital and ways to optimize them. To achieve our goals, we used analytical, statistical, and system analysis research methods. Statistical data processing was carried out using the StatSoft STATISTICA software program. The assessment of the study results is presented in the M±SD format (M – mean, SD – standard deviation). Results and Discussion. An analysis of the structure of the medical advice-seekers in the hospital showed that 42 % of patients were delivered to the hospital by an ambulance team, 32.7 % were admitted by the medical institution, and 25.3 % appeared by “self-referral”, which, taking into account their varying condition severities and comorbidity pathologies, required additional time spent on re-issuing medical documents, re-entering patients’ personal data into the medical information system, and providing different scopes of medical care. To increase the efficiency of the admitting department and the entire hospital, the position of a hospital administrator on duty was introduced; the medical triage system (triage) was developed and implemented, which, at contacting them, allows dividing patients into 3 streams differing in the demand for homogeneous treatment and prevention measures, and queuing for such activities, which made it possible to develop universal standard operating procedures and significantly improve the key indicators of hospital activities. Conclusions. As a result, innovative approaches have been proposed to optimize the admitting department activities of an emergency hospital, related to the elements of lean healthcare, which allows differentiated medical triage followed by patients’ routing depending on their condition severity.

Keywords: emergency hospital; lean healthcare; 24-hour hospital; patient routing; admitting department; triage.

For reference: Banin IN, Konovalov OE, Shulaev AV, Breusov AV. Medical and organizational aspects of optimizing the admitting department activities in an emergency hospital. The Bulletin of Contemporary Clinical Medicine. 2024; 17 (6):128-133. DOI: 10.20969/VSKM.2024.17(6).128-133.

REFERENCES

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УДК 314(470.323)

DOI: 10.20969/VSKM.2024.17(6).134-140

PDF download TRENDS IN DEMOGRAPHIC PROCESSES: MARRIAGE, DIVORCE, AND BIRTH RATES WITHIN THE KURSK REGION IN 2012–2022

BREUSOV ALEKSEY V., ORСID ID: 0000-0003-2335-3338; Dr. sc. med., Professor, Professor at the Department of Public Health, Healthcare Management and Health Economics, Institute of Continuing Education, Kursk State Medical University, 3 Karl Marx str., 305041 Kursk, Russia; Professor at the Department of Public Health, Healthcare and Hygiene, Russian Peoples’ Friendship University, 6 Miklouho-Maklaya str., 117198 Moscow, Russia. Tel.: +7 (903) 511-60-80. E-mail: ab69@yandex.ru

RYNDINA VERA V., ORСID ID: 0009-0007-8403-9752; Cand. sc. soc., Associate Professor, Department of Public Health, Healthcare organization and Health Economics of the Institute of Continuing Education, Kursk State Medical University, 3 Karl Marx str., 305041 Kursk, Russia. Tel.: +7 (910) 212-95-90. E-mail: verasc@mail.ru

SOLYANINA VICTORIA A., ORСID ID: 0000-0001-9063-8152; Cand. sc. pharm., Associate Professor, Head of the Department, Department of Public Health, Healthcare organization and Health Economics of the Institute of Continuing Education, Kursk State Medical University, 3 Karl Marx str., 305041 Kursk, Russia. Tel.: +7 (961) 339-64-10. E-mail: soljan@yandex.ru

SHULAEV ALEKSEY V., ORCID ID: 0000-0002-2073-2538; Dr. sc. med., Professor, Vice-Rector, Head of the Department of General Hygiene, Kazan State Medical University, 49 Butlerova str., Kazan, 420012 Russia. Tel.: +7 (998) 213-67-12. E-mail: alexs_shu@mail.ru

OLEYNIKOVA TATYANA ANATOLYEVNA, ORCID ID: 0000-0001-7354-8286; Cand. sc. pharm., Associate Professor, Associate Professor at the Department of Organization and Management of Pharmacy, Kursk State Medical University, 3 Karl Marx str., 305041 Kursk, Russia. Tel.: +7 (919) 27 2274. E-mail: ol_tanja@mail.ru

STEPANOVA ANASTASIA V., ORCID ID: 0009-0007-2441-2033; 6th-year student, Kursk State Medical University, 3 Karl Marx str., 305041 Kursk, Russia. Tel.: +7 (919) 216-53-62. E-mail: nastyusha.stepanova@list.ru

Abstract. Introduction. The demographic situation in the country depends on many factors and processes of population reproduction in the regions, including in the Kursk region. Monitoring marriage, divorce, and birth rates will allow quickly making managerial decisions, which will contribute to the development of the region in all areas, including developing and adjusting programs aimed at supporting families and marriage and increasing birth rates. Aim. Analysis of trends in marriage, divorce, and birth rates in the Kursk region in 2012-2022. Materials and Methods. The study of demographic processes using official data from the State Statistics Service of Russia in the Central Federal District and in the Kursk Region, as well as the findings of a sociological survey of medical university students’ opinions regarding family planning, allows us to most fully assess the trends in demographic processes occurring in these territories. Results and Discussion. A negative trend has been established in the dynamic series of marriage rates in the Kursk region (the average growth rate of the overall marriage rate is 10.9%). This figure was the lowest in 2020 – at the time of COVID-19. High marriage rates were identified in 2021 and 2022. The number of divorces during the study period increased by 2.4%. Over the past two years, there has been an increase in the number of divorce cases. The lowest overall divorce rate was recorded in 2020. The average birth rate growth was 4.2%. Over the entire period of this study, out-of-wedlock birth rates decreased on average by 1.4% in the Kursk region. KSMU students plan to start a family in 84.0% of cases, 89.9% of respondents equate cohabitation with official marriage, and 80.0% are ready to live in an informal relationship. 78.0% of respondents expressed the opinion that intimate relationships before marriage are a personal matter for everyone. The survey of the KSMU students revealed that the most respondents are ready to have a family with two children (47%). Conclusions. The decline in the overall marriage rate is associated with the transformation of family values and starting families without being officially registered with the civil registry office. The majority of KSMU students surveyed are ready to live in informal relationships, which may result in the increased out- of-wedlock birth rates, currently decreasing in the Kursk region. Direct correlations have been established between general marriage rates with divorce and birth rates (p ≤ 0.05).

Keywords: marriage rate, birth rate, divorce rate, out-of-wedlock birth rate.

For reference: Breusov AV, Ryndina VV, Solyanina VA, et al. Trends in demographic processes: Marriage, divorce, and birth rates within the Kursk region in 2012–2022. The Bulletin of Contemporary Clinical Medicine. 2024; 17 (6): 134-140. DOI: 10.20969/VSKM.2024.17(6).134-140.

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  20. Синельников А.Б. Социальная приемлемость объективных и субъективных причин для развода в современной России // Социологические исследования. – 2023. – No 4. – С.75-83. [Sinel’nikov AB. Social’naya priemlemost’ ob”ektivnyh i sub”ektivnyh prichin dlya razvoda v sovremennoj Rossii [Social acceptability of objective and subjective reasons for divorce in modern Russia]. Sociologicheskie issledovaniya [Sociological studies]. 2023; 4: 75-83. (In Russ.)]. DOI: 10.31857/ S013216250022703-6

  21. Вакуленко Е.С., Макарова М.Р., Горский Д.И. Репродуктивные намерения и динамика рождаемости населения разных стран в период пандемии COVID-19: аналитический обзор исследований // Демографическое обозрение. – 2022. – Т.9, No 4. – С.138-159. [Vakulenko ES, Makarova MR, Gorskij DI. Reproduktivnye namereniya i dinamika rozhdaemosti naseleniya raznyh stran v period pandemii COVID-19: analiticheskij obzor issledovanij [Reproductive intentions and fertility dynamics of the population of different countries during the COVID-19 pandemic: an analytical review of research]. Demograficheskoe obozrenie [Demographic Review]. 2022; 9 (4): 138-159. (In Russ.)]. DOI: 10.17323/ demreview.v9i4.16747

  22. Леонова Е.В., Лясович Т.Г. Пандемия и рождаемость: новые вызовы и перспективы (на примере Китайской Народной Республики) // Юридическая наука: история и современность. – 2022. – No 4. – С.86-91. [Leonova EV, Lyasovich TG. Pandemiya i rozhdaemost’: novye vyzovy i perspektivy (na primere Kitajskoj Narodnoj Respubliki) [Pandemic and fertility: new challenges and prospects (using the example of the People’s Republic of China)]. Yuridicheskaya nauka: istoriya i sovremennost’ [Legal science: history and modernity]. 2022; 4: 86-91. (In Russ.)].

 

EXPERIMENTAL STUDIES – TO CLINICAL MEDICINE

УДК: 615.065

DOI: 10.20969/VSKM.2024.17(6).141-145

PDF download STUDYING THE MITOCHONDRIAL TOXICITY OF PARACETAMOL AND ITS METABOLITE NAPQI

VLASOVA YULIIA A., ORCID ID: 0000-0001-5477-8975, Author ID: 604851, Cand. sc. biol., Associate Professor
at the Department of Infectious Diseases, National Medical Research Center named after V.A. Almazov, 2 Akkuratov str., 197341 Saint Petersburg, Russia. Tel.: +7-911-797-41-88. E-mail: vlasova_yua@almazovcentre.ru

BATRAKOVA KSENIYA V., ORCID ID: 0000-0002-7644-0331, Author ID: 1064781, Assistant Professor at the Department of Infectious Diseases, National Medical Research Center named after V.A. Almazov, 2 Akkuratov str., 197341
Saint Petersburg, Russia. Tel.: +7-917-367-19-99. E-mail: xenya.batrakova@yandex.ru

GOLOVANOVA NATALYA E., ORCID ID: 0000-0001-9286-8787, Author ID: 648488, Cand. sc. biol., Associate Professor at the Institute of Medicine, St. Petersburg State University, 7/9 Universitetskaya Embankment, 197341 Saint Petersburg, Russia. Tel.: +7-911-797-41-88. E-mail: nesh1764@mail.ru

TUVALEVA LIA S., ORCID ID: 0000-0001-5477-8975, Author ID: 454901, Cand. sc. med., Associate Professor at the Department of Polyclinic Therapy with an Additional Professional Education Course, Bashkir State Medical University, 3 Lenin str., 450008 Ufa, Russia. Tel.: +7-917-34-265-08. E-mail: liyatuvaleva@mail.ru

KURAMSHINA OLGA A., ORCID ID: 0000-0001-6032-9156, Author ID: 870270, Dr. sc. med., Professor at the Department of Polyclinic Therapy with an Additional Professional Education Course, Bashkir State Medical University, 3 Lenin str., 450008 Ufa, Russia. Tel.: +7-917-463-85-90. E-mail: kuramshina_olga@mail.ru

NIGMATULLIN RUSTEM KH., ORCID ID: 0009-0003-4383-8217, Cand. sc. med., Deputy Head of the Medical Unit MIA of Russia in the Republic of Bashkortostan”, 59 Karl Marx str., 450015 Ufa, Russia. Tel.: +7-917-77-38-192.
E-mail: nigrustem@yandex.ru

GRISHINA ANASTASIYА R., ORCID ID: 0009-0000-2117-4833, 5th-year student, National Medical Research Center named after V.A. Almazov, 2 Akkuratov str., 197341 Saint Petersburg, Russia. Tel.: +7-937-516-44-49.
E-mail: grianastasiiagrishina@yandex.ru

USACHEVA KSENIYA V., ORCID ID: 0009-0000-1898-3111, 5th-year student, National Medical Research Center named after V.A. Almazov, 2 Akkuratov str., 197341 Saint Petersburg, Russia. Tel.: +7-917-367-19-99. E-mail: usach.ks@gmail.com

Abstract. Introduction. Antipyretic effect of paracetamol has been known since the late 19th century. But the safety profile of this drug started to be analyzed much later, when some toxic effects were identified in using a drug that contained paracetamol, the most widely known of which was drug-induced liver damage. Aim. To study the effects of paracetamol and its toxic metabolite N-acetyl-p-benzoquinone-imine on the viability and mitochondrial membrane potential of astroglial cells in the cerebral cortex of newborn rats. Materials and Methods. Isolated astrocytes from the brains of newborn rats were exposed to 1 mM of paracetamol or 0.15 mM of its toxic metabolite NAPQI for 24 hours, then cell viability (colorimetric test for assessing the metabolic activity of cells, i.e. MTT method) and mitochondrial membrane potential (using TMPE fluorochrome) were identified. Results and Discussion. The paracetamol metabolite NAPQI decreased cell viability from 0.57 ± 0.02 down to 0.4507 ± 0.03 a.u. and mitochondrial membrane potential from 0.19±0.01 down to 0.16±0.003 a.u., the differences are significant compared to the control (p <0.05). Conclusions. The results obtained indicate the toxic effect provided by the paracetamol metabolite NAPQI on astroglial cells in the brains of newborn rats.

Keywords: paracetamol, NAPQI, mitochondrial toxicity, astroglial cells.

For reference: Vlasova YuA, Batrakova KV, Golovanova NE, et al. Studying the mitochondrial toxicity of paracetamol and its metabolite NAPQI. The Bulletin of Contemporary Clinical Medicine. 2024; 17 (6): 141-145. DOI: 10.20969/VSKM.2024.17(6).141-145.

REFERENCES

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  5. Hammad AM, Shawaqfeh B, Hikmat S, et al. The Role of Vitamin E in Protecting against Oxidative Stress, Inflammation, and the Neurotoxic Effects of Acute Paracetamol in Pregnant Female Rats. Toxics. 2023; 11(4): 368. DOI: 10.3390/toxics11040368
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  7. Howard LA, Miksys S, Hoffmann E, et al. Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics. Br J Pharmacol. 2003; 138 (7): 1376–1386. DOI: 10.1038/sj.bjp.0705146
  8. Joshi M, Tyndale RF. Induction and recovery time course of rat brain CYP2E1 after nicotine treatment. Drug Metab Dispos. 2006; 34 (4): 647–652. DOI: 10.1124/ dmd.105.008029
  9. Власова Ю.А., Загородникова К.А., Чухно А.С. Усиление ацетаминофеном свободно–радикальных процессов в клетках нейрональной линии РС12 // Бутлеровские сообщения. – 2022. – Т. 69, No2. – С.119–126. [Vlasova YuA, Zagorodnikova KA, Chukhno AS. Usilenie atsetaminofenom svobodno–radikal’nykh protsessov v kletkakh neyronal’noy linii RS12 [Acetaminophen enhances free radical processes in PC12 neuronal cells]. Butlerovskie soobshcheniya [Butlerov’s messages]. 2022; 69 (2): 119–126. (In Russ.)]. DOI: jbc–01/22–69–2–119
  10. Соколова Т.В., Рычкова М.П., Басова Н.Е., Ефимова М.Г. Витамин D3 ингибирует фагоцитарную активность астроцитов мозга крысы в первичной культуре // Журнал эволюционной биохии и физиологии. – 2022. – T.58, No3. – С.209–218. [Sokolova TV, Rychkova MP, Basova NE, Efimova MG. Vitamin D3 ingibiruet fagotsitarnuyu aktivnost’ astrotsitov mozga krysy v pervichnoy kul’ture [Vitamin D3 inhibits the phagocytic activity of rat brain astrocytes in primary culture]. ZHurnal evolyucionnoj biohii i fiziologii [Journal of Evolutionary Biochemistry and Physiology]. 2022; 58 (3): 209–218. (In Russ.)]. DOI: 10.31857/S0044452922030068
  11. Власова Ю.А., Захарова И.О., Аврова Н.Ф. Влияние альфа–токоферола и Н2О2 на мембранный потенциал митохондрий и отношение Bax/Bcl–Xl в клетках РС12 // Нейрохимия. – 2016. – Т.33, No4. – С.344–349. [Vlasova YuA, Zakharova IO, Avrova NF. Vliyanie al’fa– tokoferola i N2O2 na membrannyy potentsial mitokhondriy i otnoshenie Bax/Bcl–Xl v kletkakh RS12 [Effect of alpha–tocopherol and Н2О2 on mitochondrial membrane potential and Bax/Bcl–Xl ratio in PC12 cells]. Neyrokhimiya [Neurochemistry]. 2016; 33 (4): 344–349. (In Russ.)]. DOI: 10.7868/s1027813316040154
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  16. Aleksandrova V, Senyavina NV, Maltseva DV, Khutornenko A A, Sakharov DA. p53– and Caspase–3–Independent Mechanism of Acetaminophen Effect on Human Neural Cells. Bull of Exp Biol Med. 2016; 160 (6): 763–766. DOI: 10.1007/s10517–016–3304–7

 

 

УДК 611.08; 616.72-002.772

DOI: 10.20969/VSKM.2024.17(6).146-153

PDF download FEATURES OF BONE REMODELING DURING THE USE OF ANTISENSE OLIGONUCLEOTIDES IN A RHEUMATOID ARTHRITIS MODEL

MAKALISH TATYANA P., ORCID ID: 0000-0003-1884-2620, Scopus Author ID 57204727287, Researcher ID ABC-8226-2020, RSCI Author ID 891400, Cand. sc. biol., Associate Professor, Senior Researcher at the Central Research Laboratory, V.I. Vernadsky Crimean Federal University, 5/7 Lenina Ave., 295051 Simferopol, Russia. Tel. +7 978 7853919. E-mail: makalisht@mail.ru

GOLOVKIN ILYA O., ORCID ID: 0000-0002-3578-5130, Scopus Author ID 57212007931, Researcher ID ABA-5305-2020, RSCI Author ID 1099671, Junior Researcher at the Central Research Laboratory, V.I. Vernadsky Crimean Federal University, 5/7 Lenina Ave., 295051 Simferopol, Russia. Tel.: +7 978 9970396. E-mail: golovkin.io.1996@gmail.com

MASLOVA GALINA V., ORCID ID: 0000-0002-2538-4309, Assistant Professor at the Central Research Laboratory, V.I. Vernadsky Crimean Federal University, 5/7 Lenina Ave., 295051 Simferopol, Russia. Tel.: +7 978 5777135.
E-mail: nonstop2791@yandex.ru

PILYAVSKY NIKOLAY N., ORCID ID: 0009-0004-4541-5776, Assistant at the Central Research Laboratory, V.I. Vernadsky Crimean Federal University, 5/7 Lenina Ave., 295051 Simferopol, Russia. Tel.: +7 978 1439992.
E-mail: kolyapilyavsky@gmail.com

MARULOVA ALINA V., ORCID ID: 0009-0000-4570-2848, Assistant at the Central Research Laboratory, V.I. Vernadsky Crimean Federal University, 5/7 Lenina Ave., 295051 Simferopol, Russia. Tel.: +7 978 5153379. E-mail: alina.marulova@gmail.com

Abstract. Introduction. Despite the vast number of drugs against rheumatoid arthritis, new methods and targets are still being searched for to treat this disease. In addition to changes in the joints, bone tissue also suffers significantly from rheumatoid arthritis. Aim. To research the histological features of bone tissue in the adjuvant-induced arthritis model, as well as the expression of matrix metalloproteinase 1 and 3 after the use of antisense oligonucleotides. Materials and Methods. Rheumatoid arthritis model was obtained by introducing the complete adjuvant Freind into the base of the tail of laboratory rats. For the therapy of the resulting disease, Tocilizumab and antisense oligonucleotides were used, which block the synthesis of the factor of tumor necrosis and interleukin 6, both separately and together. The morphological changes in the tails of rats and the activity of matrix metalloproteinase in various cell populations were investigated. To identify statistically significant differences between the groups, the Kruskal — Wallis test and Mann– Whitney U test were used. Results and Discussion. In the rheumatoid arthritis model, significant erosion of bone and cartilage tissue, abundant inflammatory infiltrate around the bone and in the bone marrow cavity, and slower bone growth were revealed. The use of antisense oligonucleotides significantly slowed down the progression of the disease. Levels of metalloproteinases in bone tissue were lower in some experimental groups compared to the untreated group. Conclusions. The use of antisense oligonucleotides slows down the inflammation development and prevents bone tissue resorption in damaged bones. The most effective were injections of oligonucleotide, which blocks interleukin-6. Combination of two oligonucleotides proved to be most effective in reducing the activity of matrix metalloproteinases that reorganize the extracellular matrix of bone in arthritis, as well as reducing the synthesis of tumor necrosis factor.

Keywords: rheumatoid arthritis, antisense oligonucleotides, bone tissue.

For reference: Makalish TP, Golovkin IO, Maslova GV, et al. Features of bone remodeling during the use of antisense oligonucleotides in a rheumatoid arthritis model. The Bulletin of Contemporary Clinical Medicine. 2024; 17 (6): 146-153. DOI: 10.20969/VSKM.2024.17(6).146-153.

REFERENCES

 

1. Bian Y, Xiang Z, Wang Y, et al. Immunomodulatory roles of metalloproteinases in rheumatoid arthritis. Frontiers in Pharmacology. 2023; 14: 1285455. DOI: 10.3389/ fphar.2023.1285455

2. Jarlborg M, Gabay C. Systemic effects of IL-6 blockade in rheumatoid arthritis beyond the joints. Cytokine. 2022; 149: 155742. DOI: 10.1016/j.cyto.2021.155742

3. Shim JH, Stavre Z, Gravallese EM. Bone Loss in Rheumatoid Arthritis: Basic Mechanisms and Clinical Implications. Calcified Tissue International. 2018; 102 (5): 533-546. DOI: 10.1007/s00223-017-0373-1

4. Messina OD, Vidal M, Adami G, et al. Chronic arthritides and bone structure: focus on rheumatoid arthritis update. Aging Clinical and Experimental Research. 2023; 35 (7): 1405-1416. DOI: 10.1007/s40520-023-02432-9

5. Takeuchi T, Yoshida H, Tanaka S. Role of interleukin-6 in bone destruction and bone repair in rheumatoid arthritis. Autoimmunity Reviews. 2021; 20 (9): 102884. DOI: 10.1016/j.autrev.2021.102884

6. Bonnans C, Chou J, Werb Z. Remodelling the extracellular matrix in development and disease. Nature Reviews. Molecular Cell Biology. 2014; 15: 786–801. DOI: 10.1038/nrm3904

7. Van den Steen PE, Proost P, Brand DD, et al. Generation of glycosylated remnant epitopes from human collagen type II by gelatinase B. Biochemistry. 2004; 43: 10809– 10816. DOI: 10.1021/bi0493665

8. Burrage PS, Mix KS, Brinckerhoff CE. Matrix metalloproteinases: role in arthritis. Frontier in Bioscience. 2006; 11: 529–543. DOI: 10.2741/1817

9. Cabral-Pacheco GA, Garza-Veloz I, Castruita-De la Rosa C, et al. The roles of matrix metalloproteinases and their inhibitors in human diseases. International Journal of Molecular Science. 2020; 21: 9739. DOI: 10.3390/ ijms21249739

 

ANNIVERSARIES

УДК 614.2(091)(470.341)

DOI: 10.20969/VSKM.2024.17(6).154-159

PDF download DEPARTMENT OF PUBLIC HEALTH AND HEALTHCARE OF THE PRIVOLZHSKY RESEARCH MEDICAL UNIVERSITY: A HISTORICAL FORGE OF RESEARCH PERSONNEL - HEALTHCARE PROFESSIONALS (On the occasion of the 125th anniversary of the birth of SOPHIA I. SKUNDINA)

GURVICH NADEZHDA I., SPIN: 9917-2362, Author ID: 658791; Cand. sc. med, Associate Professor, Department of Social Medicine and Organization, Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, 603005
Nizhny Novgorod, Russia. E-mail: nade888@yandex.ru

KOPTEVA LARISA N., ORCID ID: 0000-0002-5934-1892, SPIN: 7179-4616, Author ID: 350486; Cand. sc. med., Associate Professor, Department of Social Medicine and Organization, Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, 603005 Nizhny Novgorod, Russia. E-mail: lara.kopteva@yandex.ru

PEREVEZENTSEV EGOR A., ORCID: 0000-0002-8537-6482, SPIN: 4830-7230, Author ID: 661243, Scopus Author ID: 25932314100, Cand. sc. med, Associate Professor, Department of Social Medicine and Organization, Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, 603005 Nizhny Novgorod, Russia. E-mail: peregal@yandex.ru

KAFIDOVA TATYANA I., ORCID ID: 0009-0007-1274-708X; 5th-year student, Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, 603005 Nizhny Novgorod, Russia. E-mail: kafidova.22@mail.ru

POSTNIKOVA ANNA D., ORCID ID: 0000-0001-8264-8895, SPIN: 5195-9230, Author ID: 1045393, Scopus Author ID: 57209198064; 2nd-year resident in Therapy, Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, 603005 Nizhny Novgorod, Russia. E-mail: annapostnikova98@mail.ru

BARANOV ANDREY D., ORCID ID: 0000-0003-26767915; 5th-year student, Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, 603005 Nizhny Novgorod, Russia. E-mail: andrey.baranovv1@mail.ru

Abstracts. Introduction. Department of Public Health and Healthcare of the Privolzhsky Research Medical University has a rich history and traditions dating back to the 1930s. The main areas of scientific, educational and practical activities of the department has always been the training of qualified researchers, competent administrators, and healthcare professionals for medical institutions and healthcare authorities. The aim of our study was to analyze the activities of the Department of Public Health and Healthcare of the Privolzhsky Research Medical University and show its development in historical context. Materials and Methods. Historical data was analyzed and summarized based on the regulatory and legal acts of the Privolzhsky Research Medical University, educational and scientific publications of the department, as well as biographies and research and pedagogical performance of the employees of the department. Results and Discussion. Department of Public Health and Healthcare was founded in 1931. Its founder and first head was Doctor of Medical Sciences, Professor Sophia I. Skundina (Head of the Department of Social Hygiene and Healthcare Organization in 1931-1951). Throughout the history of the Department of Public Health and Healthcare, scientific research was influenced by the most pressing health problems. Professors, associate professors and assistant professors of the department made a great contribution to the development of the research activities of the university and took an active part in the healthcare restructuring in Nizhny Novgorod and the region. Currently, the department is constantly improving its educational and methodological activities, introducing distance learning technologies and developing new additional subjects and postgraduate education programs. Conclusions. The long development of science at the department laid the foundation for the development of some modern scientific areas. Their further development, systematization and generalization made it possible to organize a full-fledged, constantly growing and expanding scientific school, the potential of which allows us to remain on the continuously updated wave of problems of the state in general, and healthcare in particular.

Keywords: Department of Public Health and Healthcare, Healthcare Organization, Social Medicine, scientific school, Nizhny Novgorod State Medical Academy, Gorky Medical Institute named after S.M. Kirov, Nizhny Novgorod Medical Institute

For reference: Gurvich NI, Kopteva LN, Perevezentsev EA, et al. Department of Public Health and Healthcare of the Privolzhsky Research Medical University: A historical forge of research personnel – healthcare professionals (on the occasion of the 125th anniversary of the birth of Sophia I. Skundina). The Bulletin of Contemporary Clinical Medicine. 2024; 17 (6): 154-159. DOI: 10.20969/VSKM.2024.17(6).154-159.

REFERENCES

 

  1. Шахов Б.Е., Буланов Г.А. Становление высшего медицинского образования в Нижнем Новгороде // Медицинский альманах – 2010. – No 1 (10).– С.37-47. [Shahov BE, Bulanov GA. Stanovlenie vysshego medicinskogo obrazovanija v Nizhnem Novgorode [The formation of higher medical education in Nizhny Novgorod]. Medicinskij al’manah [Medical Almanac]. 2010; 1 (10): 37-47. (In Russ.)].

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