Vol. 16 Issue 1 (2023)

VSKM 2023 N 1

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ORIGINAL RESEARCH

Urine microflora properties of hospitalized long¬livers in Mari El Republic population Weiss Hassan A.M. (Russia, Yoshkar Ola), Nasybullina A.A. (Russia, Yoshkar Ola), Pasynkova O.O. (Russia, Yoshkar Ola), Krasilnikov A.V. (Russia, Yoshkar Ola) P.7

The relationship of hypercholestrinemia and hypertriglyceridemia in the azerbaijan population Hajieva Y.H. (Azerbaijan, Baku) P.15

Polymorphisms of the antioxidant system enzymes SOD2 (C47T, RS4880) and CAT (G262A, RS1001179) in the pathogenesis of chronic hepatitis C Ginyatullin R.R. (Russia, Kazan), Kravchenko I.E. (Russia, Kazan), Galeeva N.V. (Russia, Kazan), Girfanutdinova E.R. (Russia, Kazan) P.20

impact of the COviD-19 pandemic on thyroid surgery: a retrospective study Zima D.V. (Russia, Crimea, Simferopol), Zyablitskaya E.Y. (Russia, Crimea, Simferopol),Golubinskaya E.P. (Russia, Crimea, Simferopol),Maksimova Р.E. (Russia, Crimea, Simferopol), Bezrukov O.F. (Russia, Crimea, Simferopol), Kubyshkin A.V. (Russia, Crimea, Simferopol), Nepritimova E.A. (Russia, Crimea, Simferopol), Kriventsov M.A. (Russia, Crimea, Simferopol), Golovkin I.O. (Russia, Crimea, Simferopol) P.28

The role of gene polymorphism of the xenobiotic biotransformation system and antioxidant protection in the development of diabetic nephropathy Kostushok N.Y. (Russia, Krasnodar), Korol I.V. (Russia, Krasnodar), Ivanova L.A. (Russia, Krasnodar), Pavlyuchenko I.I. (Russia, Krasnodar) P.34

Multimodal diagnosis in patients with metabolic syndrome components who have suffered interstitial pneumonia associated with COviD-19 Kradinova E.A. (Russia, Crimea, Simferopol),Chernorotov V.A. (Russia, Crimea, Simferopol),Kradinov A.I. (Russia, Crimea, Simferopol), Kubyshkin V.A. (Russia, Crimea, Simferopol), Kostenich V.S. (Russia, Crimea, Simferopol), Palich A.R. (Russia, Crimea, Simferopol) P.40

Echocardiographic research indicators in patients with bronchial asthma and hypertension diseaseMishlanov V. J. (Russia, Perm), Koshurnikova E.P. (Russia, Perm), Ergasheva U. P. (Russia, Perm) P.47

Comparative analysis of clinical-anamnestic and laboratory-instrumental characteristics of patients with coronary artery disease living in the far north and in the temperate climatic zoneMusikhina N.A. (Russia, Tyumen), Petelina T.I. (Russia, Tyumen), Gorbatenko E.A. (Russia, Tyumen), Larionova O.N. (Russia, Tyumen) P.52

Features of dynamics of disturbances of vibration sensitivity and pain manifestations in distal symmetrical sensory¬motor polyneuropathy in patients with diabetes mellitus of the i and ii types using a low¬frequency alternating magnetic fieldSakovets T.G. (Russia, Kazan), Bogdanov E.I. (Russia, Kazan), Barysheva E.N. (Russia, Kazan) P.64

Features of dynamics of disturbances of vibration sensitivity and pain manifestations in distal symmetrical sensory¬motor polyneuropathy in patients with diabetes mellitus of the i and ii types using a low¬frequency alternating magnetic fieldSakovets T.G. (Russia, Kazan), Bogdanov E.I. (Russia, Kazan), Barysheva E.N. (Russia, Kazan) P.64

Clinical and laboratory phenotypes of occupational сhronic obstructive pulmonary disease Fedotov V.D. (Russia, Nizhny Novgorod), Lavrenyuk N. A. (Russia, Nizhny Novgorod), Dobrotina I. S. (Russia, Nizhny Novgorod), Tulichev A. A. (Russia, Nizhny Novgorod), Solovianova E. N. (Russia, Nizhny Novgorod), Tulicheva N. A. (Russia, Nizhny Novgorod), Khudyakova E. M. (Russia, Nizhny Novgorod) P.69

REVIEWS

Psychosocial adaptation of patients with chronic cardiovascular disease Galyautdinov G.S. (Russia, Kazan),Mendelevich V.D. (Russia, Kazan),Zhidyaevskij A.G. (Russia, Kazan), Nesterina M.K. (Russia, Kazan) P.80

Diagnostic significance of endocan and endoglin as markers of endothelial dysfunction in the pathology of the cardiovascular system Zakharyan E.A. (Russia, Crimea, Simferopol), Ageeva E.S. (Russia, Crimea, Simferopol), Shramko Y.I. (Russia, Crimea, Simferopol), Maly K.D. (Russia, Crimea, Simferopol), Saranaeva E.S. (Russia, Crimea, Simferopol), Mitronina A.E. (Russia, Crimea, Simferopol), Ibragimova R.E. (Russia, Crimea, Simferopol), Gurtova A.K. (Russia, Crimea, Simferopol) P.89

HEALTH ORGANIZATION

The trends of the medical demographic indices in the Republic of Tatarstan Tafeeva E.A. (Russia, Kazan), Frolova O.A. (Russia, Kazan), Frolov D.N. (Russia, Kazan), Yangirova E.H. (Russia, Kazan) P.95

CLINICAL CASE

Special aspects of neuromorphometry in congenital hypothyroidism (clinical case) Samoilova I. G. (Russia, Tomsk), Oleynik O.A. (Russia, Tomsk), Matveeva M.V. (Russia, Tomsk), Tolmachev I.V. (Russia, Tomsk), Podchinenova D.V. (Russia, Tomsk), Vachadze T.D. (Russia, Tomsk), Galyukova D.E. (Russia, Tomsk) P.101

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ORIGINAL RESEARCH

UDC: 616-093/-098:616-053.9(470.343-25) DOI: 10.20969/VSKM.2023.16(1).7-14

PDF download URINE MICROFLORA PROPERTIES OF HOSPITALIZED LONG-LIVERS IN MARI EL REPUBLIC POPULATION

WEISS HASSAN AMIRA M., ORCID ID: 0000-0003-4589-6501, 6th year student, Medical institute of Mari State University, Russia, 424000, Yoshkar-Ola, Lenin sq., 1, e-mail: amira.waiss@mail.ru.

NASYBULLINA ADELYA A., ORCID ID: 0000-0003-3849-0079, 6th year student, Medical institute of Mari State University, Russia, 424000, Yoshkar-Ola, Lenin sq., 1, e-mail: adelya.nasybullina1998@bk.ru.

PASYNKOVA OLGA O., ORCID ID: 0000-0001-9117-8151; Scopus Author ID: 8248104000; Web of Science Researcher ID AGW-8627-2022, RSCI Author ID 218546; SPIN-code: 7853-0545, C. Med. Sci., Associate Professor, Associate Professor of the Department of fundamental medicine, Medical institute of Mari State University, Russia, 424000, Yoshkar-Ola, Lenin sq., 1, e-mail: o.o.pasynkova@yandex.ru

KRASILNIKOV ALEXEI V., ORCID ID: 0000-0002-3992-8135, Chief Physician of Republican Veteran’s Clinical Hospital, Russia, 424037, Yoshkar-Ola, Osipenko str., 24, e-mail: krasdoc@yandex.ru

Abstract. Introduction. Nowadays the presence of bacteria in the urine is considered to be the normal condition, that became the foundation of the urinal micro ora conception. The characteristics of the urine micro ora depend on the region and general health of the population and may change in time. Aim. Our goal was to assess the characteristics of urinary microbiota among hospitalized long livers in comparison to the people of younger age groups living in Mari El Republic. Materials and methods. We used the standard bacteriological analysis of midstream free voiding urine and disc di usion method. Statistical analysis was performed with the help of chi-square criteria. Totally, 720 hospitalized (during 2011-2018 years in Yoshkar-Ola hospital) patients were included into the analysis. Patients were divided into the three age groups: young (18-59 years old), elderly (60-89 years old), long-livers (90+ years old). Results and discussion. Probability of bacteria detection in the urine varied in the range 56,4% - 86,9% without di erence between elderly and long-livers, however elderly and long-livers had signi cantly higher risk of bacteria detection in the urine compared to the young age group. In female long-livers we found only gram-negative bacteria, therefore the rate of gram-positive bacteria in the urine was signi cantly lower compared to the young age group (p=0,03). Males had stable rate of gram-positive bacteria in all three age groups. Escherichia coli (56,8%) was the most common potentially pathogenic bacteria found in the urine. The resistance rate to aminoglycosides among all bacteria was 13%, to uorquinolones — 33,5%. Escherichia coli resistance to aminoglycosides was 9,6%, to uorquinolones — 29,4%.Conclusion. Long-livers and elderly patients are characterized by the similar probability of bacteria detection in urine. Urine micro ora of female long-livers contains no gram-positive bacteria. The prevalence of gram-positive bacteria in male long-livers was stable. Fluoroquinolones are not the drugs of choice for urine infection empiric therapy in our hospital due to the increased rate of resistance over the 10%. In contrast, aminoglycosides may be considered as a rst-line empiric therapy. We found no increase of resistance rate among the long livers compared to the patients of younger age groups.

Key words: urinary microbiota, Escherichia coli, age groups, antimicrobial drug resistance, uoroquinolones, aminoglycosides.

For reference: Weiss Hassan AM, Nasybullina AA, Pasynkova OO, Krasilnikov AV. Urine micro ora properties of hospitalized long-livers in Mari El Republic population. The Bulletin of Contemporary Clinical Medicine. 2023; 16(1): 7-14. DOI: 10.20969/VSKM.2023.16(1).7-14.

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UDC 616.12 – 085 DOI: 10.20969/VSKM/2023.16(1).15-19

PDF download THE RELATIONSHIP OF HYPERCHOLESTRINEMIA AND HYPERTRIGLYCERIDEMIA IN THE AzERBAIJAN POPULATION

HAJIEVA YAGUT HAJI ALI, ORCID ID: 0000-0001-7525-2040; Doctor of Philosophy in Medicine, Associate Professor, Department of Public Health and its Organization, Azerbaijan Medical University, Azerbaijan, AZ 1022, Baku, st. Gasimzade, 14, e-mail: mic_amu@mail.ru

Abstract. Introduction. According to modern concepts, dyslipidemia with an increase in the amount of cholesterol and triglycerides in the body is the main factor in the development of atherosclerosis and, accordingly, associated cardiovascular diseases. In this regard, population-based studies to identify the prevalence of dyslipidemia (hypercholesterolemia and hypertriglyceridemia) among certain population groups are of great importance. Aim. Evaluation of the role of the interdependent spread of hypercholesterolemia and hypertriglyceridemia among the population of the Republic of Azerbaijan in the development of cardiovascular diseases associated with dyslipidemia and atherosclerosis. Material and methods. Detection of cholesterol levels in the blood was carried out among 2013 randomly selected residents of the general population (of which 887 men and 1126 women) who participated in the study. After appropriate explanations and on a voluntary basis, blood was taken from the respondents for the study of cholesterol levels. Blood analysis was performed on site using a portable biochemical analyzer to quantify glucose, cholesterol, triglycerides and lactate in capillary blood. All parameters and data were collected in an Excel spreadsheet and then transferred for processing using the IBM SPSS-20 program. Results and discussion. Hypercholesterolemia was detected in 1583 (78.6±0.9%) of 2013 people who took part in the survey. Of the 1583 identi ed cases of hypercholesterolemia, 1015 cases were accompanied by cardiovascular diseases, arterial hypertension and type 2 diabetes mellitus. Of the 679 identi ed cases of hypertriglyceridemia, 589 (86.7±1.3%; t=7.12; p<0.001) had hypertriglyceridemia in combination with cardiovascular diseases, arterial hypertension and type 2 diabetes mellitus. Although hypertriglyceridemia was detected 2 times less often than hypercholesterolemia, its association with the formation of cardiovascular diseases, arterial hypertension and type 2 diabetes mellitus was signi cantly higher. Conclusion. HChS and HTG are involved in the formation of both mono- and combined diseases independently of each other, but in most cases combined diseases are formed with their joint participation.

Key words: hypercholesterolemia, hypertriglyceridemia, cardiovascular disease, atherosclerosis.

For reference: Hajiyeva YG. The relationship of hypercholesterolemia and hypertriglyceridemia in the Azerbaijani population. Bulletin of contemporary clinical medicine. 2023; 16(1): 15-19. DOI: 10.20969/VSKM/2023.16(1).15-19.

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UDC: 616.36-002.2:575.174.015.3 DOI: 10.20969/VSKM.2023.16(1).20-27

PDF download POLYMORPHISMS OF THE ANTIOXIDANT SYSTEM ENZYMES SOD2 (C47T, RS4880) AND CAT (G262A, RS1001179) IN THE PATHOGENESIS OF CHRONIC HEPATITIS C

GINYATULLIN RINAT R., ORCID ID: 0000-0002-3381-3468, Infectious disease doctor, Rybno-Slobodskaya Central Regional Hospital, Russia, Rybnaya Sloboda district, set. Rybnay Sloboda, 6 Sosnovaya St, tel. +7 (843) 61-22-162 Е-mail: big2garin@gmail.com

KRAVCHENKO IRINA E., ORCID ID: 0000-0003-4408-7542, D. Med. Sci., professor of the Department of Infectious Diseases Kazan State Medical University, Russia, Kazan, Butlerov str., 49, tel.: +7 (843) 268-80-72 e-mail: kravchencoie@mail.ru

GALEEVA NELLI V., ORCID ID: 0000-0001-5080-6529, C. Med Sci, assistant professor of the Department of Infectious Diseases Kazan State Medical University, Russia, Kazan, Butlerov str., 49, tel.: +7 (843) 268-80-72, e-mail: nelli_04@mail.ru

GIRFANUTDINOVA ENZHE R., ORCID ID: 0000-0002-9201-1000, Resident of the of the Department of Infectious Diseases Kazan State Medical University, Russia, Kazan, Butlerov str., 49, tel.: +7 (843) 268-80-72. E-mail: severusts80@gmail.com

Abstract. Introduction. An important component in the pathogenesis of chronic hepatitis C is the imbalance in oxidant and antioxidant systems. It is known that mutations in genes of antioxidant enzymes can lead to changes in antioxidant potential. Aim. To determine correlations of polymorphic variants of SOD2 (C47T, rs4880), CAT (G262A, rs1001179) superoxide dismutase and catalase genes with antioxidant system activity and features of clinical course of chronic hepatitis C. Material and Methods. The study of single nucleotide variants of genes of antioxidant enzymes of superoxide dismutase SOD2 (C47T) and catalase CAT (G262A) was undertaken in 90 patients with chronic hepatitis C and 64 healthy controls. Genomic deoxyribonucleic acid from the epithelium of the inner surface of the cheek using ‘SNP-screen ‘ diagnostic reagents was analysed. The levels of superoxide dismutase, catalase, alanine aminotransferase enzymes and degree of liver brosis were determined in the group of chronic hepatitis C patients. Correlations between investigated indexes were studied. Results and discussion. The distribution of alleles and genotypes of single nucleotide variants of catalase CAT (G262A) and superoxide dismutase SOD2 (C47T) genes among healthy subjects and chronic hepatitis C patients (p>0,05) had no signi cant di erence (p>0,05), which testi ed to absence of in uence of the studied gene variants on the risk of hepatitis C virus infection. We revealed statistically signi cant correlation of single-nucleotide variants of SOD2 (C47T) and CAT (G262A) genes with the development of chronic hepatitis C. Patients having G allele (genotypes GG and GA) of CAT (G262A) single nucleotide variants had low level of catalase enzyme, high level of alanine aminotransferase and high degree of F3-F4 brosis (correlation coe cient = -0,88*, p˂0,01). In patients with CC genotype SOD2 (C47T) a strong correlation with serum superoxide dismutase activity, severity of cytolysis syndrome (increased alanine aminotransferase) and degree of liver brosis (correlation coe cient = +0,70; p˂0,01) was established.Conclusion. In infection with hepatitis C virus polymorphic variants of SOD2 (C47T) and CAT (G262A) antioxidant system enzyme genes are the risk factors of hepatitis C progression, in uencing catalase and superoxide dismutase enzyme activity, cytolysis syndrome development, determining liver brosis formation.

Key words: chronic hepatitis C, antioxidant system, genetic polymorphism, catalase, superoxide dismutase, liver brosis.

For reference. Ginyatullin RR, Kravchenko IE, Galeeva NV, Girfanutdinova ER. Polymorphisms of the antioxidant system enzymes SOD2 (C47T, rs4880) and CAT (G262A, rs1001179) in the pathogenesis of chronic hepatitis C. The Bulletin of Contemporary Clinical Medicine. 2023; 16(1): 20-27. DOI: 10.20969/VSKM.2023.16(1).20-27.

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UDC 616-006.6-091 DOI: 10.20969/VSKM.2023.16(1).28-33

PDF download IMPACT OF THE COVID-19 PANDEMIC ON THYROID SURGERY: A RETROSPECTIVE STUDY

ZIMA DMITRY V., ORCID ID: 0000-0003-4732-0311, surgeon of the Clinical Medical Multidisciplinary Center of St. Luke (structural unit) V.I. Vernadsky Crimean Federal University 295051, Russia, Simferopol, Lenin blv, 5/7, e-mail: dmitrii_zima@mail.ru

ZYABLITSKAYA EVGENIA YU., ORCID ID: 0000-0001-8216-4196, D. Med. Sci., Leading Researcher, Central Research Laboratory at the Institute «Medical Academy named after S.I. Georgievsky» V.I. Vernadsky Crimean Federal University, 295051, Russia, Simferopol, Lenin blv, 5/7, e-mail: evgu79@mail.ru.

GOLUBINSKAYA ELENA P., ORCID ID: 0000-0003-3917-924X, Leading Researcher, Central Research Laboratory at the Institute «Medical Academy named after S.I. Georgievsky» V.I. Vernadsky Crimean Federal University,295051, Russia, Simferopol, Lenin blv, 5/7, e-mail: missive@mail.ru

MAKSIMOVA РOLINA E., ORCID ID: 0000-0001-5920-8664, sixth year student of the First Medical Faculty of the Institute «Medical Academy named after S.I. Georgievsky» V.I. Vernadsky Crimean Federal University, 295051, Russia, Simferopol, Lenin blv, 5/7, e-mail: pmaksq@mail.ru

BEZRUKOV OLEG F., ORCID ID: 0000-0002-0161-8959, D. Med. Sci., the Head of surgical Department of the Clinical Medical Multidisciplinary Center of St. Luke (structural unit) V.I. Vernadsky Crimean Federal University, 295051, Russia, Simferopol, Lenin blv, 5/7, e-mail: klinika_csmu@mail.ru

KUBYSHKIN ANATOLY V., ORCID ID: 0000-0002-9400-1826, D. Med. Sci., the Head of Department of Pathophysiology, Institute “Medical Academy named after S.I. GeorgievskyV.I. Vernadsky Crimean Federal University, 295051, Russia, Simferopol, Lenin blv, 5/7, e-mail: kubyshkin_av@mail.ru

NEPRITIMOVA ELENA A., ORCID ID: 0000-0001-8989-3615, Junior Researcher, Central Research Laboratory at the Institute «Medical Academy named after S.I. Georgievsky» V.I. Vernadsky Crimean Federal University,295051, Russia, Simferopol, Lenin blv, 5/7, e-mail: csrl@list.ru

KRIVENTSOV MAXIM A., ORCID ID: 0000-0001-5193-4311, the Head of Department of Pathological Anatomy with a sectional course at the Institute «Medical Academy named after S.I. Georgievsky» V.I. Vernadsky Crimean Federal University,295051, Russia, Simferopol, Lenin blv, 5/7, e-mail: maksimkgmu@gmail.com

GOLOVKIN ILYA O., ORCID ID: 0000-0002-3578-5130, Scopus Author ID: 57212007931, RSCI Author ID: 1099671, Junior Researcher, Central Research Laboratory at the Institute «Medical Academy named after S.I. Georgievsky» V.I. Vernadsky Crimean Federal University,295051, Russia, Simferopol, Lenin blv, 5/7, e-mail: golovkin.io.1996@ gmail.com

Abstract. Introduction. The COVID-19 pandemic has a ected the pathomorphism of many diseases due to the pathophysiological impact of the infectious process and its drug therapy, and sometimes due to changes in the organization of medical care. During the pandemic, the number of patients with thyroid nodules has increased. Aim.To analyze the impact of the COVID-19 pandemic in Crimea on the surgical aspects of thyroid diseases. Material and methods. A study was made of the impact of the COVID-19 pandemic in Crimea on the surgical aspects of thyroid diseases. Statistical work was carried out with the data of the conclusions of cytological and pathomorphological diagnostics in 1244 patients during the period before, during and after the pandemic. A detailed analysis of cytology according to Bethesda was performed with the calculation of the percentage of conclusions of classes I-VI, morphological data of histological studies with a detailed assessment of malignant neoplasms. Results and discussion. After the start of the epidemic, at the preoperative stage of diagnosing thyroid nodules, an increase in the percentage of nodes with signs of cancer was noted compared to the period of 2019. During the pandemic, a reversible increase in the number of operations for toxic goiter and an irreversible increase in the proportion of malignant tumors were established; an increase in the incidence of B-cell adenomas; the prevalence after the pandemic of more di erentiated forms of cancer with a low-risk prognosis, as well as tumors at earlier stages. Such dynamics is probably associated with a complex of factors: antigenic mimicry of the virus, its tropism for thyrocytes, stress and immunosuppression, paradoxically more timely seeking surgical care. Conclusion. The pandemic is characterized by an increase in the number of patients with primary manifestations of thyroid diseases, an increase in the number of toxic goiters and adenomas against the background of gland hyperfunction, a change in the incidence of papillary cancer - an increase in the number of patients, but the identi cation of prognostically more favorable forms.

Key words: thyroid gland, COVID-19 pandemic, cancer, pathomorphosis, surgery.

For reference: Zima DV, Zyablitskaya EY, Golubinskaya EP, et al. Impact of the COVID-19 pandemic on thyroid surgery: a retrospective study. The Bulletin of Contemporary Clinical Medicine. 2023; 16(1): 28-33. DOI: 10.20969/ VSKM.2023.16(1).28-33.

References

1. World Health Organization. https://covid19.who.int/

2. Medas F, Ansaldo GL, Avenia N, et al. Impact of the COVID-19 pandemic on surgery for thyroid cancer in Italy: nationwide retrospective study. Br J Surg. 2021;108(4):e166-e167. DOI: 10.1093/bjs/znab012

3. Søreide K, Hallet J, Matthews JB, et al. Immediate and long-term impact of the COVID-19 pandemic on delivery of surgical services. Br J Surg. 2020; 107(10):1250-1261. DOI: 10.1002/bjs.11670

4. Lisco G, De Tullio A, Jirillo E, et al. Thyroid and COVID-19: a review on pathophysiological, clinical and organizational aspects. J Endocrinol Invest. 2021;44(9):1801-1814. DOI:10.1007/s40618-021-01554-z

5. Naguib R. Potential relationships between COVID-19 and the thyroid gland: an update. J Int Med Res. 2022;50(2):3000605221082898. DOI: 10.1177/03000605221082898

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7. Khoo B, Tan T, Clarke SA, et al. Thyroid Function Before, During, and After COVID-19. J Clin Endocrinol Metab. 2021;106(2):e803-e811. DOI:10.1210/clinem/dgaa830

8. Speer G, Somogyi P. Thyroid complications of SARS and coronavirus disease 2019 (COVID-19). Endocr J. 2021;68(2):129-136. DOI:10.1507/endocrj.EJ20-0443

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10. Мидлтон М.Р. Анализ статистических данных с исполь-зованием Microsoft Excel для O ceXP // М.: БИНОМ. Лаборатория знаний, 2005. – 296 с. [Midlton MR. Analiz statisticheskih dannyh s ispol’zovaniem Microsoft Excel dlya O ceXP [Analyzing statistical data using Microsoft Excel for O ceXP]. M.: BINOM. Laboratoriya znanij [M.: BINOM. Knowledge Lab]. 2005; 296 p. (in Russ.)].

 

UDC: 616.379-008.64:616.61:575 DOI: 10.20969/VSKM.2023.16(1).34-39

PDF download THE ROLE OF GENE POLYMORPHISM OF THE XENOBIOTIC BIOTRANSFORMATION SYSTEM AND ANTIOXIDANT PROTECTION IN THE DEVELOPMENT OF DIABETIC NEPHROPATHY

KOSTUSHOK NADEZHDA Y., ORCID ID: 0000-0002-8709-6011, Assistant Professor and Postgraduate student of the Department of endocrinology faculty of advanced training and professional retraining of specialists of Kuban State Medical University, Russia, 350063, Krasnodar, Sedin str., 4, tel. +7(918)337-50-57, e-mail: ShagalovaN@ list.ru

KOROL INNA V., ORCID ID: 0000-0002-3909-9007, C. Med. Sci., Associate Professor of the Department of endocrinology faculty of advanced training and professional retraining of specialists of Kuban State Medical University, Russia, 350063, Krasnodar, Sedin str., 4, tel. +7(918)414-44-19, e-mail: innakorol1@mail.ru

IVANOVA LYUDMILA A., ORCID ID: 0000-0001-5302-3802, D. Med. Sci., the Head of the Department of endocrinology of faculty of advanced raining and professional specialist retraining of Kuban State Medical University, Russia, 350063, Krasnodar, Sedin str., 4, tel. +7(988)242-13-90, e-mail: endocrinkgmu@mail.ru

PAVLYUCHENKO IVAN I., ORCID ID: 403079 0001-0001-7080 D. Med. Sci., the Head of the Department of biology with the course of medical genetics of Kuban State Medical University, Russia, 350063, Krasnodar, Sedin str., 4, tel. +7(918)366-82-81, e-mail: inter-dekanat@mail.ru

Abstract. Introduction.The main etiopathogenetic mechanisms of the development of multifactorial diseases are genetic predisposition and environmental factors. A special role in the prognosis of type 1 diabetes mellitus is played by diabetic nephropathy, which leads to chronic kidney disease in its outcome. In the conditions of modern technogenic civilization, it is believed that the most signi cant contribution to the formation of predisposition to socially signi cant human diseases can be made by genes of enzymes of protective and adaptive systems of the body – these are, rst of all, genes of enzymes of antioxidant protection and biotransformation of xenobiotics. The aim of the study was to study the role of polymorphic variants of genes of the xenobiotic biotransformation system and antioxidant protection (G681A in the CYP2C19 gene; G1293C in the CYP2E1 gene) in the development of diabetic nephropathy in patients with type 1 diabetes mellitus. Material and methods. The study included patients with type 1 diabetes mellitus (50 people) and healthy individuals (20 people). Molecular-genetic, clinical-laboratory and biochemical research methods were used. The reliability of di erences in the distribution of genotype frequencies between groups of patients and healthy individuals was assessed by the test2, by the method of conjugate tables (four-eld table). Results and discussion. The activity of the processes of free radical oxidation and lipid peroxidation increases many times in type 1 diabetes mellitus, which is con rmed in our study by an increase in the content of malondialdehyde products against the background of an increase in the activity of enzymes of the antioxidant defense system. This is especially evident in individuals carrying heterozygous polymorphism of the CYP2C19 (G681A) and CYP2E1 (G1293C) genes, which is also combined with a more pronounced decrease in kidney function in these patients compared with carriers of other polymorphic variants of the studied genes. Conclusion. Heterozygous polymorphism of the CYP2C19 (G681A) and CYP2E1 (G1293C) genes in combination with increased activity of antioxidant defense enzymes and xenobiotic biotransformation enzymes leads to a more severe course of diabetic nephropathy in patients with type 1 diabetes mellitus.

Key words: diabetic nephropathy, antioxidant defense enzymes, gene CYP2C19 (G681A), gene CYP2E1 (G1293C).

For reference: Kostyushok NYa, Korol IV, Ivanova LA, Pavlyuchenko II. The role of gene polymorphisms in the system of biotransformation of xenobiotics and antioxidant protection in the development of diabetic nephropathy. The Bulletin of Contemporary Clinical Medicine. 2032; 16(1): 34-39. DOI: 10.20969/VSKM.2023.16(1).34-39.

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  3. Невзорова В.А., Вахрушева С.Е., Тилик Т.В., Исае-ва М.П. Полиморфизм генов глютатионтрансферазы GSTP1 и микросомальной эпоксидгидролазы EPHX1 у курильщиков и при ранних стадиях хронической об-структивной болезни легких. Пульмонология. – 2013. - No1. – C. 32-37. [Nevzorova VA, Vahrusheva SE, Tilik TV, Isaeva MP. Polimor zm genov glyutationtransferazy GSTP1 i mikrosomal’noj epoksidgidrolazy EPHX1 u kuril’shchikov i pri rannih stadiyah hronicheskoj obstruktivnoj bolezni legkih. Pul’monologiya [Polymorphism of glutathione transferase GSTP1 and microsomal epoxide hydrolase EPHX1 genes in smokers and in early stages of chronic obstructive pulmonary disease]. Pulmonologiya [Pulmonology]. 2013; 1: 32-37. (In Russ.)]. DOI:10.18093/0869-0189-2013-0-1-32-37

  4. Дьяков Д.А., Акбашева О.Е. Оксидативный стресс и сис-тема протеолиза при сахарном диабете 2 типа. Сахар-ный диабет. – 2022. - No25 (1). – С. 14-20. [D’yakov DA, Akbasheva OE. Oksidativnyy stress i sistema proteoliza pri sakharnom diabete 2 typa [Oxidative stress and the proteolysis system in type 2 diabetes mellitus]. Sakharnyy diabet [Diabetes mellitus]. 2022; 25 (1): 14-20. (In Russ.)]. DOI:10.14341/DM12402

  5. Yaribeygi H, Sathyapalan T, Atkin SL, Sahebkar A. Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus. Oxidative Med. and Cellular Longevity. 2020; 2020: 1-13. DOI:10.1155/2020/8609213

  6. Балаболкин М.И. Роль гликирования белков, окисли-тельного стресса в патогенезе сосудистых осложнений при сахарном диабете // Сахарный диабет. – 2002. - No5 (4). – C. 8-16. [Balabolkin MI. Rol’ glikirovaniya belkov, okislitel’nogo stressa v patogeneze sosudistyh oslozhnenij pri saharnom diabete [The role of protein glycation, oxidative stress in the pathogenesis of vascular complications in diabetes mellitus]. Saharnyj diabet [Diabetes mellitus]. 2002; 5 (4): 8-16. (In Russ.)]. DOI:10.14341/DM200248-16

  7. Бондарь И.А., Филиппенко М.Л., Рогова И.П., Ворони-на Е.Н. Взаимосвязь полиморфизма гена Me тилентетрагидрофолатредуктазы, eNO-синтазы и развития диабетической нефропатии у больных сахарным диа-бетом 1 типа // Бюллетень ВСНЦ СО РАМН. - 2006. - No1 (47). – C. 103-108. [Bondar’ IA, Filippenko ML, Rogova IP, Voronina EN. Vzaimosvyaz’ polimor zma gena Me tilentetragidrofolatreduktazy, eNO-sintazy i razvitiya diabeticheskoj nefropatii u bol’nyh saharnym diabetom 1 tipa [Interrelation of the polymorphism of the gene Me tylentetrahydrofolate reductase, eNO-synthase and the development of diabetic nephropathy in patients with type 1 diabetes mellitus]. Byulletenʹ VSNTS SO RAMN [Bulletin of the VSNC SO RAMS]. 2006; 1 (47): 103-108. (In Russ.)]. https:// le:///C:/Users/Сотрудник/Downloads/ vzaimosvyaz-polimor zma-gena-me-tilentetragid rofo latreduktazy-eno-sintazy-i-razvitiya-diabeticheskoy-nefropatii-u-bolnyh-saharnym -diabetom-i-tipa.pdf

12. Сорокина Ю.А., Ловцова Л.В. Полиморфизм гена эндо-телиальной синтазы азота и сахарный диабет 2 типа // Архив внутренней медицины. – 2014. – No6. - C. 34 – 37. [Sorokina YuA, Lovcova LV. Polimor zm gena endotelial’noj sintazy azota i saharnyj diabet 2 tipa [Endothelial nitrogen synthase gene polymorphism and type 2 diabetes mellitus]. Arhiv vnutrennej mediciny [Archives of Internal Medicine]. 2014; 6: 34 – 37. (In Russ.)]. DOI: 10.20514/2226-6704-2014-0-6-34-37

13. Берштейн Л.М., Васильев Д.А., Иевлева А.Г., Пороши-на Т.Е. Гормонально-метаболические и генетические маркеры чувствительности к метформину при диабете и раке: предсказание и реальность // Сахарный диабет. – 2014. - No17 (1). – C. 21-28. [Bershtejn LM, Vasil’ev DA, Ievleva AG, Poroshina TE. Gormonal’no-metabolicheskie i geneticheskie markery chuvstvitel’nosti k metforminu pri diabete i rake: predskazanie i real’nost’ [Hormonal-metabolic and genetic markers of metformin sensitivity in diabetes and cancer: prediction and reality]. Saharnyj diabet [Diabetes mellitus]. 2014; 17 (1): 21-28. (In Russ.)]. DOI: 10.14341/DM2014121-28

14. Николаев К.Ю., Урванцева И.А., Батуева К.Ю., и др. Ре-гиональные аспекты ассоциаций полиморфизма гена CYP2C19 с коронарным атеросклерозом при остром коронарном синдроме // Российский кардиологичес-кий журнал. – 2018. - No10. – C. 28-32. [Nikolaev KYu, Urvanceva IA, Batueva KYu, et al. Regional’nye aspekty associacij polimor zma gena CYP2C19 s koronarnym aterosklerozom pri ostrom koronarnom syndrome [Regional aspects of associations of CYP2C19 gene polymorphism with coronary atherosclerosis in acute coronary syndrome]. Rossijskij kardiologicheskij zhurnal [Russian Journal of Cardiology]. 2018; 10: 28-32. (In Russ.)]. DOI: 10.15829/1560-4071-2018-10-28-32

15. Маев И.В., Оганесян Т.С., Момыналиев К.Т., и др. По-лиморфизм гена цитохрома Р-450 2C19 и лечение ин-фекции Helicobacter pylori // Клиническая фармаколо-гия. - 2008. - No3. – С. 78-85. [Maev IV, Oganesyan TS, Momynaliev KT, et al. Polimor zm gena citohroma R-450 2C19 i lechenie infekcii Helicobacter pylori [Cytochrome P-450 2C19 gene polymorphism and treatment of Helicobacter pylori infection]. Klinicheskaya farmakologiya [Clinical Pharmacology]. 2008; 3: 78-85. (In Russ.)]. https:// le:///C:/Users/Сотрудник/Downloads/polimor zm-gena-tsitohroma-r-450-2c19-i-lechenie-infektsii-helicobacter-pylori%20(1).pdf

 

UDC:616-008.9-073.75:616.24-002+616.98:578.834.11 DOI: 10.20969/VSKM.2023.16(1).40-46

PDF download MULTIMODAL DIAGNOSIS IN PATIENTS WITH METABOLIC SYNDROME COMPONENTS WHO HAVE SUFFERED INTERSTITIAL PNEUMONIA ASSOCIATED WITH COVID-19

KRADINOVA ELENA A., ORCID ID: 0000-0003-4659-5823, Author ID Scopus – 6507783606. SPIN-код: 1238-6318; Author ID: 814134, D. Med. Sci., Professor of the Department of Radiation Diagnostics and Radiation Therapy, Institute “Medical Academy named after S.I. Georgievsky Crimean Federal University named after V.I. Vernadsky”, Russian Federation, Republic of Crimea, 295051, Simferopol, Lenin Boulevard, 5/7, tel.: +7 978 810-21-61, e-mail: kradinova2007@rambler.ru

CHERNOROTOV VLADIMIR A., ORCID ID: 0000-0002-3111-97477, Author ID Scopus: 6504127912, SPIN-код: 1238-6318, Author ID: 814134, D. Med. Sci., Professor, Head of the Department of Radiation Diagnostics and Radiation Therapy, Institute “Medical Academy named after S.I. Georgievsky Crimean Federal University named after V.I. Vernadsky”, Russian Federation, Republic of Crimea, 295051, Simferopol, Lenin Boulevard, 5/7, tel.: +7 978 805-55-87, e-mail: chernorotov.csmu@mail.ru

KRADINOV ALEXEI I., ORCID ID: 0000-0003-4613-7590, Author ID 890920, D. Med. Sci., Professor of the Department of Radiation Diagnostics and Radiation Therapy, Institute “Medical Academy named after S.I. Georgievsky Crimean Federal University named after V.I. Vernadsky”, Russian Federation, Republic of Crimea, 295051, Simferopol, Lenin Boulevard, 5/7, tel.: +7 978 837-14-21, e-mail: kradinov 2020@ mail.ru

KUBYSHKIN VLADIMIR A., ORCID ID: 0000-0002-9400-1826, Scopus Author ID: 57189757604, SPIN-код:4289-123, Ph.D. Sci., Associate Professor, Department of Radiation Diagnostics and Radiation Therapy, Institute “Medical Academy named after S.I. Georgievsky Crimean Federal University named after V.I. Vernadsky”, Russian Federation, Republic of Crimea, 295051, Simferopol, Lenin Boulevard, 5/7, tel.: +79787898111, e-mail: simvov@gmail.com

KOSTENICH VIKTOR S., ORCID ID: 0000-0001-5733-6953, SPIN-код: 7863-9039, AuthorID: 1139940, Lecturer, Department of Radiation Diagnostics and Radiation Therapy, Institute “Medical Academy named after S.I. Georgievsky Crimean Federal University named after V.I. Vernadsky”, Russian Federation, Republic of Crimea, 295051, Simferopol, Lenin Boulevard, 5/7, tel.: +7 978 024-04-15, e-mail: v-kostenich@mail.ru

PALICH ANASTASIA R., ORCID ID: 0000-0002-5757-1950, student of the Institute “Medical Academy named after S.I. Georgievsky Crimean Federal University named after V.I. Vernadsky”, Russian Federation, Republic of Crimea, 295051, Simferopol, Lenin Boulevard, 5/7, tel.: +7 918 970-38-36, e-mail: nastia.palich@mail.ru

PALICH ANASTASIA R., ORCID ID: 0000-0002-5757-1950, student of the Institute “Medical Academy named after S.I. Georgievsky Crimean Federal University named after V.I. Vernadsky”, Russian Federation, Republic of Crimea, 295051, Simferopol, Lenin Boulevard, 5/7, tel.: +7 918 970-38-36, e-mail: nastia.palich@mail.ru

Abstract. Introduction. Coronavirus infectious disease caused by SARS-CoV-2 characterized by vast clinical variability. Extrapulmonary complications associated with endothelial damage, thrombosis and impaired regulation of immune responses provide unfavorable impact on the outcome of the disease and rehabilitation opportunities. Also, infection in ict damage to the gastrointestinal tract, hepatobiliary system. A key - roles to avoid aforementioned conditions are proper diagnosis and treatment plan, which should be make as soon as possible among the patients with elements of metabolic syndrome. The aim of the study - analyze the possibilities of multimodal diagnostics in patients with elements of the metabolic syndrome who get infected by SARS-CoV-2. Material and methods. In 41 patients with positive SARS-CoV-2, according to a nasopharyngeal smear study, the elements of the metabolic syndrome such as an increase in body mass index, serum triglycerides, and blood pressure were determined. Dynamic ultrasound of the abdominal cavity organs, CT scan of the chest in the near and distant periods were performed. Results and discussion. In the period 2020 - 2021. in patients with elements of the metabolic syndrome who have su ered of interstitial pneumonia caused by COVID-19, the predominant patterns was di use mosaic changes in lung tissue lesions with the spread of changes in lung parenchyma to more than one segment were identi ed. In a comparative aspect, dynamic multimodal diagnostics of abdominal organs was performed, con rming extrapulmonary complications from the liver: hepatosplenomegaly (p ≤ 0.01), changes of hemodynamics in hepatic vessels in patients with MS (p ≤ 0.05), increased sti ness and formation of liver parenchyma brosis in almost 15% (F2-F3). Conclusion. Study con rm the need for careful and long-term monitoring of patients, who are a in group of risk to develop metabolic syndrome with multimodal noninvasive ultrasound control of the condition of target organs.

Key words: pneumonia caused by COVID-19, metabolic syndrome, diagnosis, extrapulmonary complications

For reference: Kradinova EA, Chernorotov VA, Kradinov AI, Kubyshkin VA, Kostenich VS, Palich AR. Multimodal diagnostics in patients with metabolic syndrome components who have su ered interstitial pneumonia associated with COVID-19. The Bulletin of Contemporary Clinical Medicine. 2023; 16(1): 40-46. DOI: 10.20969/VSKM.2023.16(1).40-46.

References

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UDC:616.12-008.331.1-06:616.248]-073.432.19 DOI: 10.20969/VSKM.2023.16(1).47-51

PDF download ECHOCARDIOGRAPHIC RESEARCH INDICATORS IN PATIENTS WITH BRONCHIAL ASTHMA AND HYPERTENSION DISEASE

MISHLANOV VITALIY Ju., ORCID ID: 0000-0002-8428-6020, D. Med. Sci. Professor, Corresponding Member of RAS, a Head of propaedeutics of internal diseases department No 1 of E.A.Vagner Perm State Medical University, address: Pushkin str. 13, fl. 260, 614000 Perm, Russia; ph. 8-950-467-76-96, e-mail: permmed@hotmail.com

KOSHURNIKOVA EKATERINA P. ORCID ID: 0000-0002-4889-9794, C. Med. Sci. Associate Professor of propaedeutics of internal diseases department No 1 of E.A.Vagner Perm State Medical University, cardiologist, ultrasound and functional diagnostician, address: Blucher str. 3, fl. 15, 614081, Perm, Russia; ph. 8-912-883-22-32, e-mail: ekaterina_koshur@mail.ru

ERGASHEVA UMIDA P. ORCID ID: 0000-0001-8941-7870, Resident of the department of Cardiology with a course of interventional methods of diagnosis and treatment, National medical research center of cardiology, Russia, 121552, Moscow, st. 3rd Cherepkovskaya, 15a, e-mail: ergasheva1998@inbox.ru

Abstract. Introduction. The presence of comorbidities in patients with bronchial asthma can increase the frequency of attacks, lead to more severe symptoms during exacerbations, and reduce the quality of life of patients. Aim. The purpose is the evaluation of morphological and functional changes in the heart of patients with a comorbidity of bronchial asthma with the hypertension disease. Material and methods. The study included 55 patients, 4 groups were formed. The main group included 19 people with a combination of bronchial asthma with the hypertension disease. Primary comparison group was 20 people with bronchial asthma. The second comparison group consisted of 16 people with hypertension. The control group consisted of 25 healthy people. Echocardiographic parameters were studied and compared with the clinical and functional picture of the disease. The analysis of the results was performed by using methods of descriptive statistics. The correlation analysis was performed with considering the Spearman’s rank correlation coe cient. Results and discussion. In the analysis of the heart morphological and functional characteristics of patients with bronchial asthma and hypertension disease in comparison with the control groups there was an increase in the left atrium dimension and volume, right ventricular wall thickness, right ventricular out ow tract at proximal, a decrease in stroke volume and end- systolic volume with negligible changes of the ejection fraction, a decrease in the thickness of the posterior wall of the left ventricle and the interventricular septum. Conclusion. This article distinguishes the characteristics of progression of the disease, as well as suggests mechanisms of pathogenetic interaction in comorbidity of hypertension disease and bronchial asthma by assessing the main parameters of echocardiography. This method is used for the earliest detection of structural and functional changes. In patients with bronchial asthma and hypertension was pronounced morphological changes in the right parts of the heart and functional changes in the pulmonary circulation in comparison in patients with isolated disease. However, because of decrease in diastolic pressure in left parts of the heart and redistribution blood volume on the right side of the heart in the left parts of the heart are less susceptible to remodeling.

Keywords: bronchial asthma, hypertension disease, comorbidity, echocardiography.

For reference: Mishlanov VJu, Koshurnikova EP, Ergasheva UP. Echocardiographic research indicators in patients with bronchial asthma and hypertension disease. The Bulletin of Contemporary Clinical Medicine. 2023; 16(1): 47-51. DOI: 10.20969/VSKM.2023.16(1).47-51.

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10. Кароли Н.А., Ребров А.П. Артериальная гипертензия у пациентов с бронхиальной астмой и хронической обструк-тивной болезнью легких // Клиницист. – 2011. – Т. 5, No 2. – С. 20-30. [Karoli NA, Rebrov АP. Arterial’naya gipertenziya u pacientov s bronhial’noj astmoj i hronicheskoj obstruktivnoj bolezn’yu legkih [Arterial hypertension in patients with bron-chial asthma and chronic obstructive pulmonary disease]. Klinicist [The Clinician]. 2011; 5(2): 20-30 р. (In Russ.)]. DOI: 10.17650/1818-8338-2011-2-20-30.

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UDC 616.12-008.1: 616.12-089: 616-08-07 DOI: 10.20969/VSKM.2023.16(1).52-59

PDF download COMPARATIVE ANALYSIS OF CLINICAL-ANAMNESTIC AND LABORATORY-INSTRUMENTAL CHARACTERISTICS OF PATIENTS WITH CORONARY ARTERY DISEASE LIVING IN THE FAR NORTH AND IN THE TEMPERATE CLIMATIC ZONE

MUSIKHINA NATALIA A., ORCID ID: 0000-0002-8280-2028, SPIN code: 9244-6574, Author ID: 6504001940, C. Med. Sci., Head of the Department of Emergency Cardiology, Scientific Department of Clinical Cardiology, Tyumen Cardiology Research Center - branch of the Federal State Budgetary Scientific Institution «Tomsk National Research Medical Center of the Russian Academy of Sciences», 634009, Russia, Tomsk, Kooperativny Lane, 5. 625026, Russia, Tyumen, Melnikaite Str., 111, phone: +7 912 396 09-11, e-mail: musihina@infarkta.net

PETELINA TATYANA I., ORCID ID: 0000-0001-6251-4179, SPIN code: 5896-5350, Author ID: 406971, D. Med. Sci., Leading Researcher of the Department of Arterial Hypertension and Coronary Insufficiency, Scientific Department of Clinical Cardiology, Tyumen Cardiology Research Center - branch of the Federal State Budgetary Scientific Institution «Tomsk National Research Medical Center of the Russian Academy of Sciences», 634009, Russia, Tomsk, Kooperativny Lane, 5. 625026, Russia, Tyumen, Melnikaite Str., 111, phone: +7 922 263 33-62, e-mail: petelina@infarkta.net

GORBATENKO ELENA A., ORCID ID: 0000-0003-3675-1503, SPIN code: 9472-4512, Author ID:568636, Junior Researcher, Laboratory of Instrumental Diagnostics, Scientific Department of Instrumental Research Methods, Tyumen Cardiology Research Center - branch of the Federal State Budgetary Scientific Institution «Tomsk National Research Medical Center of the Russian Academy of Sciences», 634009, Russia, Tomsk, Kooperativny Lane, 5. 625026, Russia, Tyumen, Melnikaite Str., 111, phone: +7 982 986 30-16, e-mail: Elena@infarkta.net

LARIONOVA OLGA N., ORCID ID: 0000-0001-7721-6633, SPIN-код: 9582-0615, Author ID: 754938, Research Laboratory Assistant, Department of Emergency Cardiology, Scientific Department of Clinical Cardiology, Tyumen Cardiology Research Center - branch of the Federal State Budgetary Scientific Institution «Tomsk National Research Medical Center of the Russian Academy of Sciences», 634009, Russia, Tomsk, Kooperativny Lane, 5. 625026, Russia, Tyumen, Melnikaite Str., 111, phone: +7 912 996 92-01, e-mail: LarionovaON@infarkta.net

Abstract. Introduction.Climatic conditions of the Far North are a factor in the early development and progression of coronary artery disease. Aim. To study the clinical-anamnestic and laboratory-instrumental characteristics of patients with coronary artery disease living in the Far North and the temperate climate zone. Material and methods.An observational analytical study of 302 patients with coronary artery disease admitted to the hospital for coronary angiography was performed. Group 1 (n=168) included patients living in the Yamalo-Nenets Autonomous Okrug, group 2 (n=134) included patients living in the temperate climate zone. The clinical status of patients, drug therapy, laboratory data, and coronary angiography results were assessed. Student’s t-test, Mann-Whitney U-test, χ2 test or Fisher’s exact test were used when comparing indicators between the groups. Results and discussion. In group 1, despite the younger age of patients, a history of myocardial infarction and chronic heart failure with a low left ventricular ejection fraction were more often recorded, which may be due to the so-called “polar tension syndrome”, which triggers pathological mechanisms of remodeling of the cardiovascular system. In elderly patients in group 2, hypertensive crises were more often recorded, and systolic blood pressure was higher and did not reach the target values. There were no di erences in the nature of the lesion of the coronary bed. In both groups, a high incidence of hyperlipidemia was established and elevated levels of homocysteine, matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1, which are markers of atherosclerotic plaque instability and rapid progression of atherosclerosis, were registered. There were no di erences in adherence to statin therapy, but the average dose of atorvastatin in group 2 was 2 times lower than in group 1. Group 1 patients were more adherent to taking antiplatelet agents, mainly due to middle-aged patients. Conclusion. In patients with coronary artery disease living in the Far North, despite their younger age, myocardial infarction and severe heart failure were more often found. All patients had a high incidence of hyperlipidemia and elevated levels of immune in ammation biomarkers. Regional di erences in prescribed therapy and in the formation of patients’ adherence to treatment were revealed.

Key words: coronary artery disease, Far North, hyperlipidemia, in ammatory biomarkers, adherence to treatment.

For reference: Musikhina NA, Petelina TI, Gorbatenko EA, Larionova ON. Comparative analysis of clinical-anamnestic and laboratory-instrumental characteristics of patients with coronary artery disease living in the far north and in the temperate climatic zone. The Bulletin of Contemporary Clinical Medicine. 2023; 16.(1): 52-59. DOI: 10.20969/ VSKM.2023.16(1).52-59.

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UDC 678.834.1, 159.9 DOI: 10.20969/VSKM.2023/16(1).60-63

PDF download THE USE OF QUESTIONNAIRES FOR DIFFERENTIAL DIAGNOSIS OF DEPRESSIVE DISORDERS, DETERMINATION OF STRESS TOLERANCE AND SOCIAL ADAPTATION AS PART OF AN INTEGRATED APPROACH OF TREATMENT AND REHABILITATION OF INTERNAL AFFAIRS OFFICERS WHO HAVE BEEN EXPOSED TO A NEW CORONAVIRUS INFECTION COVID-19

NESTERENKO ANNA B., ORCID ID: 0000-0001-8653-5601, deputy head of the unit – doctor of the Federal Medical Unit of the Ministry of Internal Affairs of Russia in the Amur region, 675000, Russia, Blagoveshchensk, Pionerskaya Str., 23, tel.: +74162594380, e-mail: anesterenko27@mvd.ru

BOGATYREV VICTOR E., ORCID ID: 0000-0001-7018-0607, deputy head of the unit – head of the commission – doctor (military medical commission) of the Federal Medical Unit of the Ministry of Internal Affairs of Russia in the Amur Region, 675000, Russia, Blagoveshchensk, Pionerskaya Str., 23, tel.: +74162594357, e-mail: vbogatyrev2@mvd.ru

VASILEVA YULIA A., ORCID ID: 0000-0002-6414-851X, the head of the center is a psychiatrist of the Center for psychophysiological diagnostics of the Federal Medical Unit of the Ministry of Internal Affairs of Russia in the Amur Region, 675000, Blagoveshchensk, Pionerskaya Str., 23, tel.: + 74162594349, e-mail: iuvasileva45@mvd.ru

KRASNOPEROVA OLGA I., ORCID ID: 0000-0003-2902-5503, medical psychologist of the Center for Psychophysiological Diagnostics of the Federal Medical Unit of the Ministry of Internal Affairs of Russia in the Amur region, 675000, Russia, Blagoveshchensk, Pionerskaya Str., 23, tel.: +74162594360, e-mail: Lolita_Blaga@mail.ru

LUKASHEVICH RADMILA A., ORCID ID: 0000-0002-7277-3366, medical psychologist of the Center for Psychophysiological Diagnostics of the Federal Medical Unit of the Ministry of Internal Affairs of Russia in the Amur region, 675000, Blagoveshchensk, Pionerskaya Str., 23, tel.: + 74162594360, e-mail: Breaz999@mail.ru

Abstract. Introduction. Psychoemotional disorders arising against the background of general somatic diseases, and often being their root cause, undoubtedly a ect not only the prognosis and dynamics of somatic pathology, but also the quality of life of the individual as a whole. Aim. The aim of the work was to assess the extent of stress load, identify premorbid deviations of the psycho-emotional state, as well as the presence of signs of borderline mental disorders in order to use the results in the planning and implementation of psychocorrective (psychotherapeutic) interventions.Material and methods. A study of the psycho-emotional state of 98 employees of internal a airs bodies who were admitted for treatment to the therapeutic department of the hospital of Federal Medical Unit of the Ministry of Internal A airs of Russia in the Amur region was carried out. 46 of those examined tested positive for COVID-19. Results and discussion. A comparative analysis of the frequency of occurrence of deviations in the psycho-emotional state in patients who underwent COVID-19 and patients who did not have a new coronavirus infection did not reveal statistically signi cant di erences. Conclusion. It was concluded that the approach of continuous psychological testing of patients entering hospitalization helps to quickly identify a contingent with signs of comorbid pathology (simultaneous coexistence of somatic diseases and psycho-emotional disorders), which in turn makes it possible to plan and implement psycho-correctional measures in a timely manner.

Key words: psychoemotional disorders, COVID-19, psychocorrectional (psychotherapeutic) measures.

For references: Nesterenko AB, Bogatyrev VE, Vasileva YA, et al. The use of questionnaires for di erential diagnosis of depressive disorders, determination of stress tolerance and social adaptation as part of an integrated approach of treatment and rehabilitation of internal a airs o cers who have been exposed to a new coronavirus infection COVID-19. The Bulletin of Contemporary Clinical Medicine. 2023; 16(1): 60-63. DOI: 10.20969/VSKM.2023.16(1).60-63.

References

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  2. Смулевич А.Б. Психосоматические расстройства в клинической практике // Москва: Медпресс-информ, 2019. – 776 с. [Smulevich AB. Psihosomaticheskie rasstrojstva v klinicheskoj praktike [Psychosomatic disorders in clinical practice]. Moskva: Medpress-inform [Moscow: Medpress-inform]. 2019; 776 p. (In Russ.)].

  3. Барканова О.В. Методики диагностики эмоциональ-ной сферы: психологический практикум // Красно-ярск: Литера-принт, 2009. – 237 с. [Barkanova OV. Metodiki diagnostiki emocional’noj sfery: psihologicheskij praktikum [Methods of diagnostics of the emotional sphere: psychological workshop]. Krasnoyarsk: Litera-print [Krasnoyarsk: Litera-print]. 2009; 237 p. (In Russ.)].

  4. Головей Л.А., Рыбалко Е.Ф. Практикум по возрастной психологии: учебное пособие // СПб.: Речь, 2005. – 688 с. [Golovey LA, Rybalko EF. Praktikum po vozrastnoj psihologii: uchebnoe posobie [Practicum on age psychology: studies help]. SPb.: Rech’ [St. Petersburg: Speech]. 2005; 688 p. (In Russ.)].

  5. Фетискин Н.П. Социально-психологическая диагнос-тика развития личности и малых групп: учебное по-собие // Москва: Изд-во Института психотерапии, 2002. – 490 с. [Fetiskin NP. Social’no-psihologicheskaya diagnostika razvitiya lichnosti i malyh grupp: uchebnoe posobie [Socio-psychological diagnostics of personality development and small groups: studies help]. Moskva: Izd-vo Instituta psihoterapii [Moscow: Publishing House of the Institute of Psychotherapy]. 2002; 490 p. (In Russ.)].

  6. Сидороенко В.А., Сухоруков А.Л. Организация психо-лого-психиатрической помощи сотрудникам органов внутренних дел Российской Федерации в ситуации пандемии COVID-19: методические рекомендации // Москва: ДТ МВД России, 2020. – Домодедово: ВИПК МВД России, 2020. – 66 с. [Sidoroenko VA, Sukhorukov AL. Organizaciya psihologo-psihiatricheskoj pomoshchi sotrudnikam organov vnutrennih del Rossijskoj Federacii v situacii pandemii COVID-19: metodicheskie rekomendacii [Organization of psychological and psychiatric assistance to policemans in the situation of the COVID-19 pandemic: methodological recommendations]. Moskva: DT MVD Rossii, Domodedovo: VIPK MVD Rossii [Moscow: Ministry of Internal A airs of Russia, Domodedovo: VIPK of the Ministry of Internal A airs of Russia]. 2020; 66 p. (In Russ.)].

7. Сидороенко В.А., Сухоруков А.Л. Организация и про-ведение терапии, медико-психологической и пси-хосоциальной реабилитации ветеранам органов внутренних дел с психическими расстройствами: учебно-методическое пособие // Домодедово: ВИПК МВД России, 2020. – 54 с. [Sidoroenko VA, Sukhorukov AL. Organizaciya i provedenie terapii, mediko-psihologicheskoj i psihosocial’noj reabilitacii veteranam organov vnutrennih del s psihicheskimi rasstrojstvami: uchebno-metodicheskoe posobie [Organization and conduct of therapy, medical-psychological and psychosocial rehabilitation for veterans of Ministry of Internal A airs of Russia with mental disorders: an educational and methodological manual]. Domodedovo: VIPK MVD Rossii [Domodedovo: VIPK of the Ministry of Internal A airs of Russia]. 2020; 54 p. (In Russ.)].

8. Ичитовкина Е.Г., Богдасаров Ю.В., Соловьев А.Г. Па-топсихологическое обследование в центрах психичес-кого здоровья МВД России: учебное пособие // Домо-дедово: ВИПК МВД России, 2019. – 118 с. [Ichitovkina EG, Bogdasarov YuV, Soloviev AG. Patopsihologicheskoe obsledovanie v centrah psihicheskogo zdorov’ya MVD Rossii: uchebnoe posobie [Pathopsychological examination in mental health centers of the Ministry of Internal A airs of Russia: study guide]. Domodedovo: VIPK MVD Rossii [Domodedovo: VIPK of the Ministry of Internal A airs of Russia]. 2019; 118 p. (In Russ.)].

9. Павлов И.С. Психотерапия в практике // Москва: ПЕРСЭ, 2012. – 608 с. [Pavlov IS. Psihoterapiya v praktike [Psychotherapy in practice]. Moskva: PERSE [Moscow: PERSE]. 2012; 608 p. (In Russ.)].

10. Кривдюк Н.А., Третьяк Л.Л. Модификация техники работы с интроектами при проработке сепарацион-ных переживаний в гештальт-подходе // Российский психотерапевтический журнал. - 2017. - 1. - С. 87 - 92. [Krivdyuk NA, Tretyak LL. Modi kaciya texniki raboty s introektami pri prorabotke separacionnyx perezhivanij v geshtal`t-podxode [Modi cation of the technique of working with introjects when working out separation experiences in the gestalt approach]. Rossijskij psixoterapevticheskij zhurnal [Russian Psychotherapeutic Journal]. 2017; 1: 87 -92. (In Russ.)].

 

UDC 616. 053.8 DOI: 10.20969/VSKM.2023.16(1).64-68

PDF download FEATURES OF DYNAMICS OF DISTURBANCES OF VIBRATION SENSITIVITY AND PAIN MANIFESTATIONS IN DISTAL SYMMETRICAL SENSORY-MOTOR POLYNEUROPATHY IN PATIENTS WITH DIABETES MELLITUS OF THE I AND II TYPES USING A LOW-FREQUENCY ALTERNATING MAGNETIC FIELD

SAKOVETS TATYANA G., ORCID ID: 0000-0002-0713-9836, Scopus Author ID: 35300646500, Web of Science ResearcherID: GXV-6528-2022, C. Med. Sci., associate professor, Department of Neurology and Rehabilitation, Kazan State Medical University, 420012, Russia, Kazan, Butlerova str., 49; e-mail: tsakovets@yandex.ru

BOGDANOV ENVER I., ORCID ID: 0000-0001-9332-8053, Scopus Author ID: 7004572584, Web of Science ResearcherID: AAV-8421-2021, D. Med. Sci., Professor, Head of the Department of Neurology and Rehabilitation, Kazan State Medical University, 420012, Russia, Kazan, Butlerova str., 49; e-mail: enver_bogdanov@mail.ru

BARYSHEVA ELENA N., ORCID ID: 0000-0001-8740-4275, Scopus Author ID: 57352887300, Head of the Physiotherapy Department of the Clinical Hospital of the Medical Unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, 420059, Russia, Kazan, Orenburgsky tract, 132; e-mail: e.barysheva@mail.ru

Abstract. Introduction. Damage to peripheral nerve bers in diabetes mellitus is considered the most severe complication that worsens the prognosis of the disease. Diabetic distal symmetrical polyneuropathy is detected in the vast majority of patients. A positive therapeutic response in patients with diabetic polyneuropathy can be obtained using low-frequency magnetic therapy. Aim. The aim was to determine the e ectiveness of low-frequency magnetic therapy in the treatment of vibration sensitivity and pain manifestations in diabetic distal symmetric sensory-motor polyneuropathy in patients on insulin therapy. Material and methods. The study included patients with manifestations of diabetic distal symmetric sensory-motor polyneuropathy, who are on isulin therapy. All patients were observed before the start of therapy and after completion of the course of treatment. There were 20 patients in the control group, 19 patients in the main group. In the main group, low-frequency magnetotherapy was prescribed for 10 days. Patients with contraindications to physiotherapy treatment were included in the control group. Results and discussion. The absence of regression of moderate and severe disorders of vibration sensitivity in the control group was observed signi cantly with a higher frequency. The torpid course of mild disorders of vibration sensitivity was noted only in the control group. In patients experiencing deep pain in the lower extremities, complete regression of mild, moderate and severe pain was observed only in the main group. Only in the control group, a torpid course of moderate deep pain manifestations was observed. Moderate acute shooting pain in the lower extremities regressed completely in the main group with a signi cantly higher frequency compared to the control group. Only in the control group, there was a lack of dynamics of moderate acute pain, a feeling of moderate burning in the legs. In the main group, a complete regression of moderate discomfort in the legs in the form of a burning sensation was noted with greater frequency. Conclusion. In the treatment of disorders of vibration sensitivity and pain manifestations in distal symmetrical sensory-motor polyneuropathy in patients with diabetes mellitus of the I and II insulin-consuming types, it is advisable to use low-frequency magnetotherapy.

Key words: diabetic polyneuropathy, diabetes mellitus, low frequency alternating magnetic eld.

For reference: Sakovets TG, Bogdanov EI, Barysheva EN. Features of dynamics of disturbances of vibration sensitivity and pain manifestations in distal symmetrical sensory-motor polyneuropathy in patients with diabetes mellitus of the I and II types using a low-frequency alternating magnetic eld. The Bulletin of Contemporary Clinical Medicine. 2023; 16(1): 64-68. DOI: 10.20969/VSKM.2023.16(1).64-68.

References

  1. Богданов Э.И., Саковец Т.Г. Эффективность церебро-лизина в лечении диабетической полиневропатии // Журнал неврологии и психиатрии им. С.С. Корсакова. – 2011. – Т.111, вып 2. – С. 35-39. [Bogdanov EI, Sakovecz TG. E ektivnost czerebrolizina v lechenii diabeticheskoj polinejropatii [The e ectiveness of cerebrolysin in the treatment of diabetic polyneuropathy]. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova [Journal of Neurology and Psychiatry]. 2011; 111(2): 35-39. (in Russ.)].

  2. Ахмеджанова Л.Т., Баринов А.Н., Строков И.А. Диа-бетические и недиабетические полиневропатии у пациентов с сахарным диабетом //Журнал невроло-гии и психиатрии им. С.С. Корсакова. – 2018. – Т.118, вып.4. – С. 113-120. [Akhmedzhanova LT, Barinov AN, Strokov IA. Diabeticheskie i nediabeticheskie polinejropatii u paczientov s sakharnym diabetom [Diabetic and non-diabetic polyneuropathy in patients with diabetes mellitus]. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova [Journal of Neurology and Psychiatry]. 2018;118(4): 113-120. (in Russ.)]. DOI: 10.17116/jnevro201811841113-120

  3. Зилов А.В. Варианты диабетической автономной по-линевропатии: возможные пути коррекции // Доктор. Ру. – 2021. – Т.20, вып. 2. – С. 60-66. [Zilov AV. Varianty diabeticheskoj avtonomnoj polinejropatii: vozmozhnye puti korrekczii [Variants of diabetic autonomic polyneuropathy: possible ways of correction]. Doktor.Ru [Doctor.Ru]. 2021; 20(2): 60-66. (in Russ.)]. DOI: 10315/1727-2378-2021-20-2-60-66

  4. Daousi C, MacFarlane IA, Woodward A, et al. Chronic painful peripheral neuropathy in a urban community: a controlled comparison of people with and without diabetes. Diabet Med. 2004; 21: 976-982. DOI: 10.1111/j.1464-5491.2004.01271.x

5. Botez SA, Herrmann DN. Sensory neuropathies, from symptoms to treatment. Curr Opin Neuirol. 2010; 23: 502-508. DOI: 10.1097/WCO.0b013e32833c7a19

6. В.М. Боголюбов (ред.). Медицинская реабилитация. Том I // Москва: Издательство БИНОМ, 2010. – 461с. [Bogolyubov VM, editor. Mediczinskaya reabilitacziya. Tom I [Medical rehabilitation. Volume 1]. Moskva: Izdatelstvo BINOM [Moscow: Publishing house BINOM]. 2010; 461p. (in Russ.)].

7. Волотовская А.В., Козловская Л.Е. Физические фак-торы в лечении сахарного диабета и его осложнений. (Учебно-методическое пособие) // Физиотерапия, баль-неология и реабилитация. – 2013. – No2. – С. 34-42. [Volotovskaya AV, Kozlovskaya LE. Fizicheskie faktory v lechenii sakharnogo diabeta i ego oslozhnenij (Uchebno-metodicheskoe posobie) [Physical factors in the treatment of diabetes mellitus and its complications (Educational manual)]. Fizioterapiya, balneologiya i reabilitacziya [Physiotherapy, balneology and rehabilitation ]. 2013; 2: 34-42. (in Russ.)].

8. Ясногорский В.Г. (ред.). Справочник по физиотера-пии // Москва: Медицина, 1992. – 512 с. [Yasnogorskii VG., editor. Spravochnik po zioterapii [Handbook of physiotherapy]. Moskva: Mediczina [Moscow: Medicine]. 1992; 512p. (in Russ.)].

9. Александров В.В., Алгазин А.И. Основы вос-становительной медицины и физиотера-пии // Москва: ГЭОТАР-Медиа, 2013. – 136 с. [Aleksandrov VV, Algazin AI. Osnovy vosstano vitelnoj mediczinyi zioterapii [Fundamentals of restorative medicine and physiotherapy]. Moskva: GEOTAR-Media [Moscow: GEOTAR-Media]. 2013; 136p. (in Russ.)].

10. Пономаренко Г.Н. (ред.). Физическая и реабилитаци-онная медицина: национальное руководство // Мос-ква: ГЭОТАР-Медиа, 2020. – 688 с. [Ponomarenko GN, editor. Fizicheskaya i reabilitaczionnaya mediczina: naczionalnoe rukovodstvo [Physical and rehabilitation medicine: national leadership]. Moskva: GEOTAR-Media [Moscow: GEOTAR-Media]. 2020; 688p. (in Russ.)].

11. Куликов А.Г., Воронина Д.Д. Возможности общей магни-тотерапии в лечении и реабилитации (обзор) // Вопро-сы курортологии, физиотерапии и лечебной физичес-кой культуры. – 2016. – Т.93, вып. 2. – С.35-39. [Kulikov AG, Voronina DD. Vozmozhnosti obshchej magnitoterapii v lechenii i reabilitacii (obzor) [The potential of general magnetic therapy for the treatment and rehabilitation (a review)]. Voprosy kurortologii, zioterapii, i lechebnoi zicheskoi kultury [Issues of balneology, physiotherapy and therapeutic physical culture]. 2016; 93(2): 4852. (In Russ.)]. DOI: https://DOI.org/10.17116/kurort2016248-52

12. Илларионов В.Е. Магнитотерапия // Москва: Ле-нанд, 2016. – 136 с. [Illarionov VE. Magnitoterapiya [Magnetotherapy]. Moskva: Lenand [Moscow: Lenand]. 2016; 136 р. (In Russ.)].

13. Улащик В.С. (ред.). Магнитотерапия: теоретические основы и практическое применение // Минск: Бела-руская навука, 2015. – 379 с. [Ulashchik VS, editor. Magnitoterapiya: teoreticheskie osnovy i prakticheskoe primenenie [Magnetotherapy: theoretical foundations and practical application]. Minsk: Belaruskaya navuka [Minsk: Belarusian Science]. 2015; 379p. (in Russ.)].

 

UDC: 616.24-036.12+613.62 DOI: 10.20969/VSKM.2023.16(1).69-79

PDF download CLINICAL AND LABORATORY PHENOTYPES OF OCCUPATIONAL СHRONIC OBSTRUCTIVE PULMONARY DISEASE

FEDOTOV VASILY D., ORCID ID: 0000-0003-4307-9321, SPIN-код: 6335-6935, Author ID: 678642, C. Med. Sci., senior research scientist of the Clinical Department of the Federal budget scientific institution “Nizhny Novgorod research institute for hygiene and occupational pathology” Rospotrebnadzor, 603105, Nizhny Novgorod Oblast, Nizhny Novgorod, Semashko Str., 20, Russian Federation, Internal medicine and General medicine practice V.G.Vogralika, Associate Professor, Volga Medical Research University, Nizhny Novgorod, Russian Federation. Russian Federation, Nizhny Novgorod, Minin and Pozharsky sq., 10/1, 603950, BOX-470; Chief Freelance Specialist of pulmonology of Ministry of Health of Nizhegorodskaya oblast, tel. +7 920 014 61 06, e-mail: basil11@yandex.ru

LAVRENYUK NATALIA A., ORCID ID: 0000-0002-2439-5196, C. Med. Sci., Head of the Occupational Pathology Unit, Clinical Department of the Federal Budgetary Science Institution ‘’Nizhny Novgorod Research and Scientific Institute of Hygiene and Occupational Pathology’’ of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing; tel.: +7 831 419 61 94; е-mail: recept@nniigp.ru

DOBROTINA IRINA S., ORCID ID: 0000-0001-6892-8380, SPIN-код: 1083-5471, Author ID: 312760, C. Med. Sci., Internal Medicine and General medicine practice V.G.Vogralika, Associate Professor, Volga Medical Research University, Russian Federation. Russian Federation, Nizhny Novgorod, Minin and Pozharsky sq., 10/1, 603950, BOX-470; tel. +7 960 184 19 62; e-mail: dobrotina@mail.ru

TULICHEV ALEXANDER A., ORCID ID: 0000-0002-3157-2218, RSCI Author ID: 942582, C. Med. Sci., Internal Medicine department, Assistant Professor Volga Medical Research University, Russian Federation. Russian Federation, Nizhny Novgorod, Minin and Pozharsky sq., 10/1, 603950, BOX-470; tel. +7 962 513 35 02; e-mail: mr.tulichev@mail.ru

SOLOVIANOVA ELENA N., ORCID ID: 0000-0002-7965-1177 SPIN-код: 1654-0683; AuthorID: 440494, C. Med. Sci., Internal Medicine and General medicine practice V.G.Vogralika, Associate Professor, Volga Medical Research University, Russian Federation, Nizhny Novgorod, Minin and Pozharsky sq., 10/1, 603950, BOX-470; tel. +7 951 913 93 17; e-mail: elenas-nn@mail.ru

TULICHEVA NINA A., ORCID ID: 0000-0001-8654-0515, student of General medicine faculty of Volga Medical Research University, Russian Federation, Nizhny Novgorod, Minin and Pozharsky sq., 10/1, 603950, BOX-470; tel. +7 962 513 35 02; e-mail: mr.tulichev@mail.ru.

KHUDYAKOVA EKATERINA M., ORCID ID: 0000-0002-1802-4719, student of General medicine faculty of Volga Medical Research University, Russian Federation, Nizhny Novgorod, Minin and Pozharsky sq., 10/1, 603950, BOX-470; tel. +7 920 068 38 38; e-mail: ekhudyakova23@yandex.ru.

Abstract. Introduction. The pathogenetic di erences between the phenotypes of occupational chronic obstructive pulmonary disease which develop after silica-containing dust exposure are still unclear. The research aims to study the relationship of occupational chronic obstructive pulmonary disease clinical phenotypes with in ammation. Material and methods. 123 patients were included in the study. Basing on the forced expiratory volume in 1 second, clinical symptoms and the history of exacerbations, the patients were divided into 4 groups (group 1 - 30 people (24%) phenotype «B1», group 2 - 16 people phenotype «B2» (13%), group 3 - 32 people (26%) phenotype «D», group 4 - 45 people (36%) phenotype «A»). The groups of patients were comparable in age, body mass index, duration of working period in hazardous conditions, the number of cardiovascular comorbidities (p>0.05), but di ered in spirometry, the number of exacerbations and the number of eosinophils in the blood (p = 0.02, p = 0.0001 and p=0.006) and therapy. Results and discussion. The concentration of hyaluronic acid in the blood serum was increased in all groups of the patients, but most of all in the «D» phenotype, 204.5 ng/ml, p=0.0024. Immunoglobulin A was above the normal level in the patients with phenotypes «B2» and «D»6,32 and 9.84 mg/l, p=0.0059. Endothelial synthase in phenotypes «B2» and «D» was more than 2 times higher than in other groups (57.9 and 64.5 pg/ml, р=0.013). The groups did not di er in terms of endothelin-1. Correlation analysis revealed statistically signi cant (p<0.05) correlations between exacerbations, eosinophils, comorbidities, forced expiratory volume in 1 second. Immunoglobulin A had a direct relationship with endothelial synthase and an inverse relationship with forced expiratory volume in 1 second. Hyaluronic acid directly correlated with the number of exacerbations and eosinophils and inversely with forced expiratory volume in 1 second. Endothelial synthase had a direct relationship with eosinophils and cardiovascular comorbidities and an inverse relationship with forced expiratory volume in 1 second. Conclusion. The concentration of hyaluronic acid, immunoglobulin A and endothelial synthase in the blood serum re ects the activity of remodelling bronchi, the risk of exacerbations and connections to cardiovascular comorbidities.

Key words: COPD, occupational diseases, in ammation, hyaluronic acid.

For references: Fedotov VD, Lavrenyuk NA, Dobrotina IS, et al. Clinical and laboratory phenotypes of occupational chronic obstructive pulmonary disease. The Bulletin of Contemporary Clinical Medicine. 2023; 16(1): 69-79. DOI: 10.20969/VSKM.2023.16(1).69-79.

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6. Овчаренко С.И. К вопросу о фенотипах хронической об-структивной болезни легких // Фарматека. – 2011. – No 4 (217). – С. 44-46. [Ovcharenko SI. K voprosu o fenotipah hronicheskoj obstruktivnoj bolezni legkih [The issue of phenotypes in chronic obstructive pulmonary disease]. Farmateka [Farmateka]. 2011; 4 (217): 44-46.] (In Russ.)]. DOI: 10.18411/spc-18-01-2018-12

7. Miravitlles M, Soler-Cataluña JJ, Calle M et al. Treatment of COPD by clinical phenotypes: putting old evidence into clinical practice. Eur Respir J. 2013; 41 (6): 1252-1256. DOI: 10.1183/09031936.00118912

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UDC: 616.12-008:615.851 DOI: 10.20969/VSKM.2023.16(1).80-88

PDF download PSYCHOSOCIAL ADAPTATION OF PATIENTS WITH CHRONIC CARDIOVASCULAR DISEASE

GALYAUTDINOV GENSHAT S., ORCID ID: 0000-0001-7403-0200; Scopus Author ID: 6507148532, Resercher ID: АБЕ-6977-2020, RSCI Author ID: 294616; D. Med. Sci., Professor, Department of Internal Medicine, Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. 7 (843) 236-04-11, e-mail: galgen077@mail.ru

MENDELEVICH VLADIMIR D., ORCID ID: 0000-0001-8489-3130; Scopus Author ID: 6602765981, Resercher ID: О-4908-2016, RSCI AuthorID: 538389; D. Med. Sci., Professor, Head of the department of psychiatry and medical psychology, Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. +7 (843) 236-70-49, e-mail: mendelevich_vl@mail.ru

ZHIDYAEVSKIJ ALEXANDER G., ORCID ID: 0000-0002-4245-5201; Scopus Author ID: 57217636256, Resercher ID: ABE-5593-2020, RSCI Author ID: 990136; assistant professor, Department of Psychiatry and Medical psychology, Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. +7 (843) 236-05-63, e-mail: zhidyaevskij@mail.ru (author for correspondence)

NESTERINA MARIA K., 0000-0001-6901-5903; Scopus Author ID: 57734765200, Resercher ID: GXG-6933-2022, RSCI Author ID: 1167592; 6th year student, Faculty of general medicine, Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. +7 (906) 130-33-66, e-mail: mari.nesterina@mail.ru

Abstract. Introduction. The high prevalence of chronic cardiovascular diseases, which are the leading cause of morbidity and mortality throughout the world, makes this problem not only medical but also social. It becomes important to study the role of psychosocial risk factors in their development and progression, as well as mechanisms allowing to adapt to the changing living conditions for this reason. Aim. The aim of the study is to review the current information on the process of adaptation to chronic cardiovascular disease from social, psychological and clinical perspectives.Material and Methods. A review of current research from 1997 to 2022, published in eLibrary, Google Scholar, and PubMed databases, was conducted on the analysis of psychosocial and clinical risk factors and their impact on patient adaptive capacity in chronic cardiovascular disease using the two keywords «psychosocial adaptation», «cardiovascular disease». Results and discussion. Psychosocial adaptation to chronic cardiovascular disease occurs in complex from social, psychological and clinical points of view. The patient’s social status, which includes, in addition to the level of education, profession, quali cation and lifestyle, can change under the in uence of the disease. The process of psychological adaptation depends on the psychological and psychiatric characteristics of the patient, such as personality traits, severity of a ective disorders, and cognitive status. The presence of the illness, severity of its course, severity of symptoms and adherence to therapy naturally in uence both psychological and social adaptation.Conclusion. Successful recognition of psychosocial risk factors and correct evaluation of patient’s adaptation to chronic cardiovascular disease will allow to carry out qualitative cardiological rehabilitation, directly in uence quality of life, adherence to treatment and improve prognosis of the main disease.

Key words: psychosocial adaptation, cardiovascular diseases, cardiac rehabilitation.

For reference: Galyautdinov GS, Mendelevich VD, Zhidyaevskij AG, Nesterina MK. Psychosocial adaptation of patients with chronic cardiovascular disease. The Bulletin of Contemporary Clinical Medicine. 2023; 16(1): 80-88. DOI: 10.20969/VSKM.2023.16(1).80-88.

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UDC 616.1-008.6:616-07 DOI: 10.20969/VSKM.2023.16(1).89-94

PDF download DIAGNOSTIC SIGNIFICANCE OF ENDOCAN AND ENDOGLIN AS MARKERS OF ENDOTHELIAL DYSFUNCTION IN THE PATHOLOGY OF THE CARDIOVASCULAR SYSTEM

ZAKHARYAN ELENA A., ORCID ID: 0000-0002-7384-9705, Scopus ID: 57216831737, SPIN-code: 6221-9905, C. Med. Sci., Associate professor, Department of Internal Medicine No1, Medical Academy named after S.I. Georgievsky, Crimean Federal University, 295006, Russia, Crimea, Simferopol, Lenina blvd. 5/7, tel. +79787879353, e-mail: locren@yandex.ru

AGEEVA ELIZABETH S., ORCID ID: 0000-0003-3770-2965, Scopus ID: 39361073400, SPIN code: 9958-7298, D. Med. Sci., Associate Professor, Head of Medical Biology Department, Medical Academy named after S.I. Georgievsky, Crimean Federal University, 295006, Russia, Crimea, Simferopol, Lenina blvd. 5/7, e-mail: ageevaeliz@rambler.ru

SHRAMKO YULIANA I., ORCID ID: 00-0003-4946-7317, SPIN-code: 5040-6016, C.Biological Sci., Associate Professor of General and Clinical Pathophysiology Department, Medical Academy named after S.I. Georgievsky, Crimean Federal University, 295006, Russia, Crimea, Simferopol, Lenina blvd. 5/7, tel. +79787529673, e-mail: shramko_6767@mail.ru

MALY KONSTANTIN D., ORCID ID: 0000-0002-6591-2719, SPIN-code: 9812-4544, C. Med. Sci., Associate Professor, Department of Biochemistry, Medical Academy named after S.I. Georgievsky, Crimean Federal University, 295006, Russia, Crimea, Simferopol, Lenin Blvd, 5/7, e-mail: kdmalykd@gmail.com

SARANAEVA ELVINA S., ORCID ID: 0000-0002-5362-2327, student, Medical Academy named after S.I. Georgievsky, Crimean Federal University, 295006, Russia, Crimea, Simferopol, Lenina blvd, e-mail: miss. elvinasaranaeva@gmail.com

MITRONINA ANZHELIKA E., ORCID ID: 0000-0002-5022-9079, student, Medical Academy named after S.I. Georgievsky, Crimean Federal University, 295006, Russia, Crimea, Simferopol, Lenina blvd. +79781330734, e-mail: mitronina1998@gmail.com

IBRAGIMOVA REGINA E., ORCID ID: 0000-0003-0734-9400, SPIN-code: 7718-5222, student, Medical Academy named after S.I. Georgievsky, Crimean Federal University, 295006, Russia, Crimea, Simferopol, Lenin Blvd. 5/7, tel. +79787710984, e-mail: irregina.2000@mail.ru

GURTOVA ANNA K., ORCID ID: 0000-0001-8633-1166, laboratory assistant of Center of Collective Use of Scientific Equipment «Molecular Biology», Medical Academy named after S.I. Georgievsky, Crimean Federal University, 295006, Russia, Crimea, Simferopol, Lenin Blvd, 5/7, e-mail: gurtovayanna@mail.ru

Abstract. Introduction. Endothelial dysfunction is a key link in the atherosclerotic process and therefore the study of speci c markers may provide new opportunities for the development of therapeutic strategies for its correction.Aim of this work was to study the role of new biomarkers of endothelial dysfunction (endocan and endoglin) in early detection and prognosis of cardiovascular pathology. Material and methods. Meta-analysis of the literature sources in the scienti c electronic bibliographic databases PubMed and Social Sciences Citation Index was carried out. Results and discussion. The meta-analysis demonstrated diagnostic and prognostic signi cance of endoglin and endocan in pathology of the cardiovascular system. Conclusion. Having reviewed the publications of leading scienti c journals, it is clear that endothelium plays an important role both as a trigger and a catalyst in many cardiovascular diseases. The data presented in this review demonstrates the important role of new biomarkers of endothelial dysfunction, such as endocan and endoglin, in early diagnosis and determining the prognosis of cardiovascular pathology. Further exploration of options for their interpretation may be crucial for developing new therapeutic and diagnostic strategies.Key words: endocan, endoglin, biomarkers, endothelial dysfunction.

For reference: Zakharyan EA, Ageeva ES, Shramko JI, et al. Diagnostic signi cance of endocan and endoglin as markers of endothelial dysfunction in the pathology of the cardiovascular system. The Bulletin of Contemporary Clinical Medicine. 2023; 16(1): 89-94. DOI: 10.20969/VSKM.2023.16(1).89-94.

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HEALTH ORGANIZATION

UDC 614.1 (470.41) DOI: 10.20969/VSKM.2023.16(1).95-100

PDF download THE TRENDS OF THE MEDICAL DEMOGRAPHIC INDICES IN THE REPUBLIC OF TATARSTAN

TAFEEVA ELENA A., ORCID ID: 0000-0002-4161-2463; D. Med. Sci., professor of the Department of General Hygiene of the Kazan State Medical University, 420012, Russia, Kazan, Butlerov str., 49, tel.: +7 917263-08-21, e.mail: tafeeva@mail.ru

FROLOVA OKSANA A., ORCID ID: 0000-0002-6675-0563; D. Med. Sci., professor of the Department of General Hygiene of the Kazan State Medical Academy – filiation of Russian Medical Academy of Continued Medical Education, 420012, Russia, Kazan, Mushtary St., 11, tel.: +7 906322-85-33, e.mail: frolova_oa@mail.ru

FROLOV DMITRIJ N., ORCID ID: 0000-0001-9274-4231; C. Med. Sci., assistant professor of the Department of General Hygiene of the Kazan State Medical Academy – filiation of Russian Medical Academy of Continued Medical Education, 420012, Russia, Kazan, Mushtary St. 11, tel.: +7 906327-71-40, e.mail: frolmed@mail.ru

YANGIROVA ELZA H., ORCID ID: 0000-0002-4138-8588; SPIN-code: 6204-6939; postgraduate student of the Department of General Hygiene of the Kazan State Medical Academy – filiation of Russian Medical Academy of Continued Medical Education, 420012, Russia, Kazan, Mushtary St., 11, tel.: +7 906322-33-40, e.mail: elza-y@mail.ru

Abstract. Introduction. The regions of the Russian Federation di er in fertility, mortality and dynamics of medical demographic indices. These di erences are to be considered for improvements the demographic situation in the country. Aim. The aim of the study is analyzing regional features of the development of the medical and demographic situation for 2006-2020 in the Republic of Tatarstan. Material and methods. This research was conducted based on the o cial statistical reporting forms from 2016 to 2020 using descriptive statistical methods. Results and discussion. In the general structure of the republic population over the studied period, the proportion of elderly people has increased by 0.61%, children - by 1.01%, while the share of the working-age population has decreased by 1.58%. Mortality rates for men of working age are on average 4 times higher than for women. The greatest di erence in indicators is noted for such reasons as injuries and poisoning (6 times), diseases of the blood system (5.3 times), respiratory diseases (4 times). The highest rate of increase in mortality among people of retirement age for the period 2016-2020 are observed due to diseases of the respiratory system and the endocrine system. The overall increase in mortality in men was 72.8% and 81.5%, in women - 146.4% and 81.1%, respectively, the highest increase in mortality was observed in 2020 due to the spread of COVID-19. Conclusion. The analysis carried out testi es to the tendencies formed in the Republic of Tatarstan in reducing the number of working-age population, birth rates, in the background of an increase in mortality. Due to the spread of COVID-19 in 2020, there was a sharp increase in the death rate of the working-age and retirement age population. The study of the structure of causes of death showed di erences in the distribution of deaths by age and sex among the adult population of the republic.

Key words: demographic potential; mortality; life expectancy; population; gender di erences.

For reference. Tafeeva EA., Frolova OA, Frolov DN, Yangirova EH. The trends of the medical demographic indices in the Republic of Tatarstan. The Bulletin of Contemporary Clinical Medicine. 2023; 16(1): 95-100. DOI: 10.20969/ VSKM.2023.16(1).95-100.

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CLINICAL CASE

UDC 616.441-007.21 DOI: 10.20969/VSKM.2023.16(1).101-107

PDF download SPECIAL ASPECTS OF NEUROMORPHOMETRY IN CONGENITAL HYPOTHYROIDISM (CLINICAL CASE)

SAMOILOVA IULIIA G., ORCID ID: 0000-0002-2667-4842, Dr. Med. Sci, Professor, Professor of the Pediatric Diseases Department, Head of the Clinical Research Center of the Siberian State Medical University, Chief Specialist of the Tomsk Region Department of Health for Medical Prevention, 634050, Tomsk, Moskovsky Tract, 2, tel. +79138267424, e-mail: samoilova_y@inbox.ru

OLEYNIK OXANA A., ORCID ID: 0000-0002-2915-384X, Cand. Med. Sci., Associate Professor, Associate Professor of the Pediatric Diseases Department, expert of the Center for Clinical Research of the Siberian State Medical University, 634050, Tomsk, Moskovsky Tract, 2, tel. +79138503840, e-mail: oleynikoa@mail.ru

MATVEEVA MARIIA V., ORCID: 0000-0001-9966-6686, Dr. Med. Sci, Professor of the Pediatric Diseases Department of the Siberian State Medical University, 634050, Tomsk, Moskovsky Tract, 2, tel. +79138152552, e-mail: matveeva.mariia@yandex.ru

TOLMACHEV IVAN V., ORCID ID: 0000-0002-2888-5539, Candidate of Medical Sciences, head of Target Search Laboratory of Medical Engineering Technologies of the Foundation for Advanced Research, Assoc. Professor of the Department of Medical and Biological Cybernetics of the Siberian State Medical University, 634050, Tomsk, Moskovsky Tract 2, tel. +79095419329, e-mail: ivantolm@mail.ru

PODCHINENOVA DARIA V., ORCID ID: 0000-0001-6212-4568, Candidate of Medical Sciences, Assoc. Professor of the Pediatric Diseases Department of the Siberian State Medical University, 634050, Tomsk, Moskovsky Tract, tel.: +79234034931 , e-mail: darvas_42@mail.ru

VACHADZE TAMARA D., ORCID ID: 0000-0001-6384-1972, resident, Department of Endocrinology of the Siberian State Medical University, 634050, Tomsk, Moskovsky Tract 2, tel.: +79627790562, e-mail: vtooma@mail.ru

GALYUKOVA DARYA E., ORCID ID: 0000-0003-2660-469X, 3rd year student of pediatrics faculty, Siberian State Medical University. 634050, Tomsk, Moskovsky Trakt 2, phone: +79131274461, e-mail: darya.galyukova@yandex.ru

Abstract. Introduction. Based on the neonatal screening results the congenital hypothyroidism prevalence in the Russian Federation is 1 case per 3950 newborns. Moreover, thyroid hormones play an important role in glial myelination, neuronal migration, cortical layer formation, synaptogenesis and neurogenesis. Aim. To assess a patient with congenital hypothyroidism brain morphometric and neuropsychological status. Material and methods. This article describes a 24-year-old patient clinical case with congenital hypothyroidism, thyroid agenesis and cognitive decline associated with altered brain substance volume. Results and discussion. Many studies have shown that hypothyroidism is associated with cognitive de cits such as reduced attention, memory, psychomotor and executive functions. This clinical case con rms the known ndings in the drug withdrawal background, with functions related to visual-constructive skills, uency and memory being most a ected by thyroid hormone de ciency. Some authors attribute these changes to decreased regional cerebral blood ow in brain regions associated with cognitive functions. A number of functional magnetic resonance imaging (MRI) studies have found the default mode network or reversible changes deactivation in the brain during working memory tasks. It is possible that functional changes occur when there is impaired the pathological process compensation, but in the congenital hypothyroidism changes, agenesis and increased duration case are possible. A study and brain morphometric revealed a decrease in subcortical structures, which some authors believe are responsible for neuroplasticity and cognitive function. Conclusion. In connection with this clinical example ndings, attention should be drawn to the timely diagnosis importance as early as possible in the maternity home, euthyroidism maintenance, and hormonal status monitoring with correction also in adulthood, taking into account the possible e ect on changes in brain structures and neuropsychological disorders development.

Key words: Congenital hypothyroidism, thyroid agenesis, MoCA Test, Magnetic resonance imaging, Brain morphometry.

For reference: Samoilova YuG, Oleynik OA, Matveeva MV, et al. Special aspects of neuromorphometry in congenital hypothyroidism (clinical case). The Вulletin of Contemporary Clinical Medicine. 2023. 16(1): 101-107. DOI: 10.20969/ VSKM.2023.16(1).101-107.

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