Vol. 16 Issue 2 (2023)

VSKM 2023 N 2

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ORIGINAL RESEARCH

Pancreatitis in HIV-infected patients. Causes and trends. Analysis of a case series. Gafarov U.O. (Russia, Moscow), Plotkin D.V. (Russia, Moscow), Reshetnikov M.N. (Russia, Moscow), Romanova E.Y. (Russia, Moscow), Barskiy В.G. (Russia, Moscow), Mokhov D.A (Russia, Moscow), Sterlikov S.A. (Russia, Moscow), Bogorodskaya E.M. (Russia, Moscow) P.7

Nicotine addiction and hormonal imbalance in pregnant smokers with varying degrees of COPD severity Dzyubailo A.V. (Russia, Samara), Lotkov V.S. (Russia, Samara) P.18

The role of renal dysfunction in fatal outcomes in the liver cirrhosis Karzakova L.M. (Russia, Cheboksary), Ivanova A.L. (Russia, Cheboksary), Kudryashov S.I. (Russia, Cheboksary), Odintsova A.V (Russia, Cheboksary), Gurieva A.V (Russia, Cheboksary), Komelyagina N.A. (Russia, Cheboksary), Gavrilova E.S. (Russia, Cheboksary), Anisimova T.A. (Russia, Cheboksary) P.23

Forecasting the probability of COPD development depending on the smoking experience of women of fertile age Lotkov V.S. (Russia, Samara), Dzyubailo A.V. (Russia, Samara) P.34

Development of a simple questionnaire for early detection of premorbid functional health impairments Martyushev Poklad A.V. (Russia, Moscow), Yankevich D.S. (Russia, Moscow), Savitskaya N.G. (Russia, Moscow), Grechko A.V. (Russia, Moscow) P.39

Prognosis of significant ischemic events and lethal outcome in patients with myocardial infarction with chronic obstructive pulmonary disease Prokofyeva T.V. (Russia, Аstrakhan), Polunina O.S. (Russia, Аstrakhan), Polunina E.A. (Russia, Аstrakhan) P.49

The role of leptin in various ageassociated pathologies in old age and in long-livers Topolyanskaya S.V. (Russia, Moscow), Mаmchich D.S. (Russia, Moscow), Eliseeva T.A. (Russia, Moscow), Vakulenko O.N. (Russia, Moscow), Ratchina S.A. (Russia, Moscow), Dvoretski L.I. (Russia, Moscow), Lytkina K.A.(Russia, Moscow), Melkonyan G.G. (Russia, Moscow) P.56

The role of subjective and objective criteria in the assessment of the state of patients with bronchobstructive diseases in remote monitoring conditions Shubina K.M. (Russia, Moscow), Mishlanov V. J. (Russia, Permian), Nikitin I.G. (Russia, Moscow), Bekker K.N. (Russia, Permian), Emelkina V.V. (Russia, Permian), Shubin I.V (Russia, Moscow) P.64

REVIEWS

History and reality of application the 6 minute walk test in children Bushueva E.V. (Russia, Cheboksary) Dianova T.I. (Russia, Cheboksary) Ivanova O.N. (Russia, Cheboksary) Gerasimova L.I. (Russia, Moscow), Petrov A.G. (Russia, Cheboksary) Sitdikova I.D. (Russia, Kazan) P.72

Autism spectrum disorder in children: diagnostic significance of electroencephalography Gamirova R.G (Russia, Kazan), Safina A.R. (Russia, Kazan), Gorobets E.A. (Russia, Kazan), Safina D.R. (Russia, Kazan) P.80

Features of neurotransmitter regulation of ureteral function and prospects for the search for new stoneremoving drugsZyapbarov A.M. (Russia, Kazan), Ziganshin A.U. (Russia, Kazan) P.89

The impact of state institutional norms on the management of the range policy of organizations wholesale medicinesUrusova L.K. (Russia, Pyatigorsk), Goryachev A.B. (Russia, Moscow), Kabakova T.I. (Russia, Pyatigorsk) P.95

FROM PRACTICAL EXPERIENCE

A clinical case of «long-COVID» with damage to the endocrine, cardiovascular and pulmonary systems Ivanova L.A. (Russia, Кrasnodar), Kovalenko Y.S. (Russia, Кrasnodar), Korol I.V. (Russia, Кrasnodar), Smezinova A.V. (Russia, Кrasnodar), Kokova Y.A. (Russia, Кrasnodar), Ananeva E.I.(Russia, Кrasnodar) P.102

CLINICAL CASE

Clinical case of juvenile ossifying fibroma (jof) mimicking frontal sinus mucocele Zeleva O.V. (Russia, Samara), Zelter P.M. (Russia, Samara), Kolsanov A.V. (Russia, Samara), Sidorov E.A. (Russia, Samara), Tsoi A.V.(Russia, Samara), Ivanova O.V. (Russia, Samara) P.108

HEALTHCARE ORGANIZATION

The procedure for cooperation of the center for disaster medicine with medical organizations in emergency situationsKubasov R.V. (Russia, Arkhangelsk),
Sokolnikov V.A. (Russia, Arkhangelsk), Martynov V.O.(Russia, Arkhangelsk), Smykovskaya A.I. (Russia, Arkhangelsk), Krymova E.S. (Russia, Arkhangelsk), Menshutin I.Y. (Russia, Arkhangelsk), Kalinin A.G. (Russia, Arkhangelsk), Sannikov A.L. (Russia, Arkhangelsk), Kubasova E.D. (Russia, Arkhangelsk) P.113

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ORIGINAL RESEARCH

UDC: 616.98.578-828.6-06.616.37

DOI: 10.20969/VSKM.2023.16(2).7-17

PDF download PANCREATITIS IN HIV-INFECTED PATIENTS. CAUSES AND TRENDS. ANALYSIS OF A CASE SERIES.

GAFAROV UMEDZHON O., ORCID ID: 0000-0003-0445-4053; Researcher ID GPK-1408-2022; RSCI Author ID 1009568; SPIN-code: 2538-0186; С. Med. Sci, Surgeon of the Moscow Research and Clinical Center for TB Control of the Moscow Healthcare Department, Russia, 107014, Moscow, Stromynka St., 10; Surgeon of the Rozanov Moscow Regional Hospital, Ivanteevsky branch, Russia, 141280, Moscow Region, Ivanteevka, Pervomayskaya St., 39; e-mail: umed_78@mail.ru

PLOTKIN DMITRIY V., ORCID ID: 0000-0002-6659-7888; Scopus Author ID: 7003838496; Researcher ID AAF-1358-2020; RSCI Author ID 904034; SPIN-code: 7425-9947; С. Med. Sci, Associate Professor, Surgeon of the Moscow Research and Clinical Center for TB Control of the Moscow Healthcare Department, Russia, 107014, Moscow, Stromynka St., 10.; Associate Professor of the Department of General Surgery of the Pirogov Russian National Research Medical University, Russia, 117997, Moscow, Ostrovityanova St., 1.;e-mail: kn13@list.ru

RESHETNIKOV MIKHAIL N., ORCID ID: 0000-0002-4418-4601; Scopus Author ID: 57202426327; Researcher ID AAC-7191-2020; RSCI Author ID 904021; SPIN-code: 7292-6640; С. Med. Sci, Surgeon of the Moscow Research and Clinical Center for TB Control of the Moscow Healthcare Department, Russia, 107014, Moscow, Stromynka St., 10; e-mail: taxol@bk.ru

ROMANOVA ELENA Y., ORCID ID: 0000-0001-6092-9100; RSCI Author ID 1079534; SPIN-code: 6995-6846; Infectiologist of the Moscow Research and Clinical Center for TB Control of the Moscow Healthcare Department, Russia, 107014, Moscow, Stromynka St., 10; e-mail: docavgust@yandex.ru

BARSKIY BORIS G., ORCID ID: 0000-0001-5414-9319; RSCI Author ID 742696; С. Med. Sci, The Head of Department of the Moscow Research and Clinical Center for TB Control of the Moscow Healthcare Department, Russia, 107014, Moscow, Stromynka St., 10; e-mail: bbarsky@mail.ru

MOKHOV DMITRIY A., ORCID ID: 0000-0002-8320-8813; Surgeon of the Rozanov Moscow Regional Hospital, Ivanteevsky branch, Russia, 141280, Moscow Region, Ivanteevka, Pervomayskaya St., 39; e-mail: mokhovdmitriy@ yandex.ru

STERLIKOV SERGEY A., ORCID ID: 0000-0001-8173-8055; Scopus Author ID: 55183564500; Researcher ID AAG-8146-2019; RSCI Author ID 679902; SPIN-code: 8672-4853; Doctor of Medical Sciences, Chief Researcher, Russian Research Institute of Health, Russia, 127254, Moscow, Dobrolyubova St., 11; e-mail: sterlikov@list.ru

BOGORODSKAYA ELENA M., ORCID ID: 0000-0003-4552-5022; Scopus Author ID: 15764671200; Researcher ID AAE-7936-2022; RSCI Author ID: 276837; Doctor of Medical Sciences, Professor, Director of the Moscow Research and Clinical Center for TB Control of the Moscow Healthcare Department, Russia, 107014, Moscow, Stromynka St., 10.; e-mail: BogorodskayaEM@zdrav.mos.ru

Abstract. Introduction. Acute pancreatitis is common in HIV-infected patients and has a number of signi cant features that directly a ect the methods of diagnosis and treatment. Aim. To study risk factors of acute pancreatitis development in patients with HIV-infection with immunosuppressive disorders and to determine treatment and diagnostic algorithm in this group of patients. Material and Methods. Anamnestic data, results of diagnosis and treatment of two groups of patients with acute pancreatitis were analyzed. The rst group included 79 patients with acute pancreatitis combined with HIV infection who were admitted to the clinic for the period from 2017 to 2021. The second group consisted of 558 HIV-negative patients with acute pancreatitis. Results and discussion. In the group of HIV-positive patients it turned out that alimentary factors caused pancreatitis in 31,7% of patients, biliary concretions and hypertension in 16,5% of patients, it was not possible to establish an initiating factor of the disease in 16,5% of cases. In people living with HIV drugs and infectious agents caused acute pancreatitis in 11,4% and 24,1% of cases respectively. Alimentary factors were in the lead in the group of HIV–negative patients (52,2%), gallstone disease was considered as the second main cause of pancreatitis – 36,0% of cases, viral infections and the consequences of the use of drugs respectively accounted for 1,6%, and in 10,2% of patients the cause of acute pancreatitis remained unknown. Discussion. As ourstudy showed, in patients with normal immune status the drug etiology of pancreatitis prevailed in the structure of the causes of pancreatitis, in patients with immunode ciency, respectively, infectious causes of pancreatitis were dominant. Based on the obtained data on the cause of pancreatitis, the rational therapeutic and diagnostic algorithm was formed, the use of which in clinical practice will allow timely initiation of etiotropic and pathogenetic therapy in a group of HIV-positive patients. Conclusion. The etiological structure of HIV-associated acute pancreatitis directly depends on the patient’s immune status and di ers in many ways from that of HIV-negative patients or patients receiving antiretroviral therapy. The severity of the disease and the risk of death remain high in acute pancreatitis caused by infectious agents against the background of immunosuppression.

Key words: acute pancreatitis, HIV, antiretroviral therapy, immune status.

For reference: Gafarov UO, Plotkin DV, Reshetnikov MN, et al. HIV-associated pancreatitis. Causes and trends. Analysis of case series. The Bulletin of Contemporary Clinical Medicine. 2023; 16(2): 7-17.
DOI: 10.20969/VSKM.2023.16(2).7-17.

References

  1. UNAIDS. Fact sheet - Latest global and regional statistics on the status of the AIDS epidemic. – 2022; 6p. https://www.unaids.org/sites/default/files/media_asset/ UNAIDS_FactSheet_en.pdf

  2. Справка ФБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора «ВИЧ-инфекция в Российской Федерации на 31 декабря 2021 г.» - 2021. – 4с. [Spravka FBUN «Central’nyj nauchno-issledovatel’skij institut epidemiologii» Rospotrebnadzora «VICH-infekciya v Rossijskoj Federacii na 31 dekabrya 2021 g.». [Reference of the FBIS «Central Research Institute for Epidemiology» of the Federal Service for Surveillance]. 2021; 4p. (In Russ.)]. http://www.hivrussia.info/wp-content/uploads/2022/03/ Spravka-VICH-v-Rossii-na-31.12.2021-g.pdf

  3. Ермолов А.С., Иванов П.А., Благовестнов Д.А., и др. Диагностика и лечение острого панкреатита: монография // Москва: Видар, 2013 – 384 с. [Ermolov AS, Ivanov PA, Blagovestnov DA, et al. Diagnostika i lechenie ostrogo pankreatita: monogra ya [Diagnosis and treatment of acute pancreatitis: monograph]. Moskva: Vidar [Moscow: Vidar]. 2013; 384 p. (In Russ.)].

  4. Петри С.И., Дарвин В.В. Острый панкреатит у ВИЧ-инфицированных пациентов: современное состояние проблемы // Международный научно-исследовательский журнал. – 2021. – No6(108). – С. 137-142. [Petri SI, Darvin VV. Ostryj pankreatit u VICH-in cirovannyh pacientov: sovremennoe sostoyanie problem [Acute pancreatitis in HIV-infected patients: the current developments]. Mezhdunarodnyj nauchno-issledovatel’skij zhurnal [International Research Journal]. 2021; 6(108): 137-142. (In Russ.)]. DOI: 10.23670/ IRJ.2021.108.6.060

  5. Ющук Н.Д., Маев И.В., Овлашенко Е.И., Кучерявый Ю.А. Поражение поджелудочной железы при ВИЧ-инфекции // Клинические перспективы гастроэнтерологии, гепатологии. - 2007. - No1. - С. 16-28. [Yushchuk ND, Maev IV, Ovlashenko EI, Kucheryavyj YuA. Porazhenie podzheludochnoj zhelezy pri VICH-infekcii [Pancreatic pathology at HIV-infection]. Klinicheskie perspektivy gastroenterologii, gepatologii [Clinical prospects of gastroenterology, hepatology]. 2007; 1: 16-28. (In Russ.)].

  6. Oliveira NM, Ferreira FA, Yonamine RY, et al. Antiretroviral drugs and acute pancreatitis in HIV/AIDS patients: is there any association? A literature review. Einstein (Sao Paulo). 2014; 12(1): 112-9. DOI: 10.1590/s1679-45082014rw2561

  7. Dragovic G. Acute pancreatitis in HIV/AIDS patients: an issue of concern. Asian Pac J Trop Biomed. 2013; 3(6): 422-5. DOI: 10.1016/S2221-1691(13)60091-X

  8. Клинические рекомендации: ВИЧ–инфекция у взрослых. – 2020. – 230с. – [Klinicheskie rekomendacii [Clinical guidelines]. VICH–infekciya u vzroslyh [HIV infection in adults]. – 2020; 230 p. (In Russ.)]. http:// rushiv.ru/wp-content/uploads/2020/06/KR79-ot-21.04.20. pdf?ysclid=l6s9n4yj1l190452654

  9. Szőke D, Ridolfo A, Valente C, et al. Frequency of Pancreatic Hyperamylasemia in Human Immunode ciency Virus-Positive Patients in the Highly Active Antiretroviral Therapy Era. Am J Clin Pathol. 2016; 145(1): 128-33. DOI: 10.1093/ajcp/aqv020

  10. Chehter EZ, Longo MA, Laudanna AA, et al. Involvement of the pancreas in AIDS: a prospective study of 109 post-mortems. AIDS. 2000; 14(13): 1879-86. DOI: 10.1097/00002030-200009080-00001

  11. Плоткин Д.В., Родоман Г.В., Решетников М.Н., и др. CMV–инфекция, как причина острой хирургической патологии // Хирург. – 2019. - No7. - С. 55-69. [Plotkin DV, Rodoman GV, Reshetnikov MN, et al. CMV–infekciya, kak prichina ostroj hirurgicheskoj patologii [CMV infection as the cause of acute surgical pathology]. Khirurg [Surgeon]. 2019; 7: 55-69. (In Russ.)].

  12. Manfredi R, Calza L. HIV infection and the pancreas: risk factors and potential management guidelines. Int J STD AIDS. 2008; 19(2): 99-105. DOI: 10.1258/ ijsa.2007.007076

  13. Blanchard JN, Wohlfeiler M, Canas A, et al. Pancreatitis with didanosine and tenofovir disoproxil fumarate [corrected]. Clin Infect Dis. 2003; 37(5): e57-62. DOI: 10.1086/376991

  14. Пантелеев А.М. Клиническое представление о патогенезе генерализации туберкулеза у больных ВИЧ-инфекцией // Туберкулез и болезни легких. – 2015. – T. 93 No2. – С. 26-31. [Panteleev AM. Klinicheskoe predstavlenie o patogeneze generalizacii tuberkuleza u bol’nyh VICH-infekciej [Clinical notion of the pathogenesis of tuberculosis generalization in HIV-infected patients]. Tuberkulez i bolezni legkih [Tuberculosis and lung disease]. 2015; 93(2): 26-31. (In Russ.)]. DOI: 10.21292/2075-1230-2015-0-2-26-31

  15. Зюзя Ю.Р., Зимина В.Н., Пархоменко Ю.Г., и др. Корреляция морфологических признаков туберкулеза и состояния иммунного статуса при ВИЧ-инфекции // Туберкулез и болезни легких. – 2014. – Т. 92 No 11. - С. 48-53. [Zyuzya YuR, Zimina VN, Parkhomenko YuG, et al. Korrelyaciya morfologicheskih priznakov tuberkuleza i sostoyaniya immunnogo statusa pri VICH-infekcii [Correlation between the morphological signs of tuberculosis and the immune status in HIV infection]. Tuberkulez i bolezni legkih [Tuberculosis and lung disease]. 2014; 92(11): 48-53. (In Russ.)].

  16. Клинические рекомендации. Острый панкреатит у взрослых. – 2020. – 63с. – [Klinicheskie rekomendacii [Clinical guidelines]. Ostryj pankreatit u vzroslyh [Acute pancreatitis in adults]. – 2020; 63p. (In Russ.)]. https:// cr.minzdrav.gov.ru/schema/326_4

  17. Rawla P, Bandaru SS, Vellipuram AR. Review of Infectious Etiology of Acute Pancreatitis. Gastroenterology Res. 2017; 10(3): 153-158. DOI: 10.14740/gr858w

  18. Kanbay M, Sekuk H, Yilmaz U, et al. Acute pancreatitis associated with combined lisinopril and atorvastatin therapy. Dig Dis. 2005; 23(1): 92-4. DOI: 10.1159/000084729

  19. Dickey SE, Mabry WA, Hamilton LA. Possible Sulfamethoxazole/Trimethoprim-Induced Pancreatitis in a Complicated Adolescent Patient Posttraumatic Injury. J Pharm Pract. 2015; 28(4): 419-24. DOI: 10.1177/0897190015585750

  20. Ahmad J, Sayedy N, Sanivarapu R, et al. Pancreatitis in an Immunocompromised Patient. Case Rep Crit Care. 2021; 2021: 8811396. DOI: 10.1155/2021/8811396

  21. Osiro S, Muhammad R, Ruiz J, et al. Acute necrotizing pancreatitis in the setting of CMV viremia and AIDS: a case report and review of literature from 1980 to 2012. JOP. 2012; 13(6): 705-11. DOI: 10.6092/1590-8577/1197

  22. Marques L.M., Hurtado R., Chehter E.Z. HIV and Pancreas in the HAART ERA: Endocrinological Patterns. JOP. J Pancreas (Online) 2015; 16(6): 540-546.

  23. New-Aaron M, Ganesan M, Dagur RS, et al. Pancreatogenic Diabetes: Triggering E ects of Alcohol and HIV. Biology (Basel). 2021; 10(2): 108. DOI: 10.3390/ biology10020108

  24. Anderson F, Thomson SR. Pancreatitis in a high HIV prevalence environment. S Afr Med J. 2017; 107(8): 706-709. DOI: 10.7196/SAMJ.2017.v107i8.1029

  25. ВИЧ-инфекция и СПИД: национальное руководство (под ред. акад. РАМН В.В. Покровского). - М.: ГЭО- ТАР-Медиа, 2013. - 608 с. [VICH-infekciya i SPID. (pod. red. akad. VV Pokrovskogo) [HIV infection and AIDS: National guidelines (ed. acad. RAMS VV Pokrovsky). Moskva: GEOTAR-Media [Moscow: GEOTAR-Media]. 2013. 608 p. (In Russ.)]

  26. Чернявская О.А., Иоанниди Е.А., Фролова А.С. К вопросу о тайне диагноза ВИЧ-инфекции // Биоэтика. - 2016. - Т. 9. - No2. - C. 45-47. [Chernyavskaya OA, Ioannidi EA, Frolova AS. K voprosu o taine diagnoza VICH-infekcii [To the question of the mystery diagnosis HIV infection]. BIOETICA [BIOETHICS]. 2016; 9(2): 45-47. (In Russ.)].

  27. Almaguer AG, Mendoza-Flores L, Sánchez-López LA, et. al. Correlation between rapid HIV testing and fourthgeneration ELISA results for HIV detection among pregnant patients in the delivery room. Int J Gynaecol Obstet. 2017; 137(1): 31-33. DOI: 10.1002/ijgo.12094

  28. Kufa T, Kharsany AB, Cawood C, et. al. Misdiagnosis of HIV infection during a South African community-based survey: implications for rapid HIV testing. J Int AIDS Soc. 2017; 29; 20(6): 21753. DOI: 10.7448/IAS.20.7.21753

  29. Мельников В.Л., Рыбалкин С.Б., Афтаева Л.Н., Митрофанова Н.Н. Клинико-эпидемиологические особенности ВИЧ-инфекции в зависимости от уровня CD4 клеток // Мед. науки. – 2016. Т.3. No 39. – С. 115-121. [Melnikov VL, Rybalkin SB, Aftaeva LN, Mitrofanova NN. Kliniko-epidemiologicheskie osobennosti VICH-infekcii v zavisimosti ot urovnya CD4 kletok [Clinical and epidemiological features of HIV infection depending on the level of CD4 cells]. Med. nauki [Medical Sciences]. 2016; 3(39): 115-121. (In Russ.)]. DOI: 10.21685/2072-30322016-3-13

  30. Rafailidis PI, Mourtzoukou EG, Varbobitis IC, Falagas ME. Severe cytomegalovirus infection in apparently immunocompetent patients: a systematic review. Virol J. 2008; 27; 5:47. DOI: 10.1186/1743-422X-5-47

 

UDC 616.24-008.46:613.84:618.2

DOI: 10.20969/VSKM.2023.16(2).18-22

PDF download NICOTINE ADDICTION AND HORMONAL IMBALANCE IN PREGNANT SMOKERS WITH VARYING DEGREES OF COPD SEVERITY

DZYUBAILO ANNA V., ORCID ID: 0000-0001-6908-4829, C. Med. Sci., associate professor, Head of the Department of Internal Medicine with a course of Outpatient Medicine and Hemotransfusiology of Samara State Medical University, Russia, 443099, Samara, Chapaevskaya St., 89, e-mail: adzyubajlo@yandex.ru

LOTKOV VYACHESLAV S., ORCID ID: 0000-0002-3995-6988, D. Med. Sci,. professor of the Department of Occupational Diseases and Clinical Pharmacology named after professor V.V. Kosarev of Samara State Medical University, Russia, 443099, Samara, Chapaevskaya str., 89, e-mail: v.s.lotkov@gmail.com

Abstract. Introduction. The relationship between the degree of nicotine addiction and the functional state of the thyroid gland, the adrenocorticotropic hormone-cortisol system and hormone imbalance in pregnant women smokers with chronic obstructive pulmonary disease was studied. Aim. The aim of the study was to identify and evaluate the relationship between the degree of nicotine dependence and hormonal imbalance of the thyroid gland, cortisol and progesterone in pregnant smokers with varying degrees of chronic obstructive pulmonary disease severity. Material and methods. The study is based on the results of studying changes in blood hormone indicators in 107 smoking women with chronic obstructive pulmonary disease and 136 non-smoking women in di erent trimesters of pregnancy observed in the antenatal clinic. The control group consisted of healthy non-smoking patients. The diagnosis of chronic obstructive pulmonary disease was made based on the clinical recommendations of the Russian Respiratory Society (2021). The reliability of the results was evaluated using parametric statistics methods. The data obtained were processed using the Statistica 10 program, Microsoft Excel 2010. Results and discussion. The presented data revealed the presence in smokers of a statistically signi cant and very close relationship between the degree of nicotine dependence and the indicators of the imbalance of the hormones studied in all trimesters of pregnancy, with maximum values in the third trimester.This is due to the fact that it is in the third trimester of pregnancy that the maximum increase in the indicators of all studied hormones occurs, even if at the initial stage of pregnancy the indicator could be less than the lower limit of the reference interval, as in the case of thyroid-stimulating hormone.Conclusion. Nicotine addiction creates environment for the development of endocrine imbalance of thyroid hormones, adrenocorticotropic hormone, cortisol and progesterone.

Keywords: degree of nicotine dependence, imbalance of sex hormones.

For reference: Dzyubailo A.V., Lotkov V.S. Nicotine addiction and hormonal imbalance in pregnant smokers with varying degrees of COPD severity. The Bulletin of Contemporary Clinical Medicine. 2023; 16(2): 18-22.
DOI: 10.20969/VSKM.2023.16(2).18-22.

References

1. Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD). 2018.

2. Федеральные клинические рекомендации по лечению ХОБЛ, 2018. [Federal’nye klinicheskie rekomendacii po lecheniyu HOBL [Federal Clinical guidelines for COPD treatment]. 2018. (In Russ.)].

3. Eisner MD, Anthonisen N, Coultas D, et al. An official American Thoracic Society public policy statement: novel risk factors and the global burden of chronic obstructive pulmonary disease. Am J RespirCrit Care Med 2010; 182: 693–718. (http://www.goldcopd. com). DOI: 10.1164/rccm.200811-1757ST

4. Lamprecht B, McBurnie MA, Vollmer WM, et al. BOLD Collaborative Research Group: COPD in never smokers: results from the population-based burden of obstructive lung disease study. Chest 2011; 139: 752–763. (http://www.goldcopd.com). DOI: 10.1378/ chest.10-1253

5. Цветкова О.А., Мустафина М.Х. Хроническая обструктивная болезнь легких у женщин. Пульмонология. – 2010. – No 1. – С. 111-118. [Cvetkova OA, Mustafina MH. Hronicheskaya obstruktivnaya bolezn’ legkih u zhenshchin. [Chronic obstructive pulmonary disease in women]. Pul’monologiya [Pulmonology]. 2010; 1; 111-118. (In Russ.)]. DOI:10.18093/0869-0189-2010-1-111-118

6. Ануварбекова А.А., Уланбекова Т.У. Никотиновая зависимость и факторы, мотивирующие и поддерживающие ее. Международный журнал прикладных и фундаментальных исследований. 2017. – No 12-2. – С. 257-261. [Anuvarbekova AA, Ulanbekova TU. Nikotinovaya zavisimost’ i faktory, motiviruyushchie i podderzhivayushchie ee. [Nicotine addiction and factors motivating and supporting it]. Mezhdunarodnyj zhurnal prikladnyh i fundamental’nyh issledovanij [International Journal of Applied and Fundamental Research]. 2017; 12-2: 257-26. (In Russ.)].

7. Давудова Д.М. Особенности клинического течения бронхиальной астмы и коррекция дисгормональных нарушений у женщин фертильного возраста вне и во время беременности. Автореферат дис. канд. мед. наук. М. – 2008. – 21с. [Davudova DM. Osobennosti klinicheskogo techeniya bronhial’noj astmy i korrekciya disgormonal’nyh narushenij u zhenshchin fertil’nogo vozrasta vne i vo vremya beremennosti [Features of the clinical course of bronchial asthma and correction of dishormonal disorders in women of fertile age outside and during pregnancy]. Avtoreferat dis. kand. med. nauk [Abstract dis. candidate of Medical Sciences]. M; 2008; 21s. (In Russ.)].

8. LE Seyler Jr, О Pomerleau, J B Fertig, et al. The effect of smoking on the secretion of ACTH and cortisol. The science of life. 1984; 34(1): 57-65. DOI: 10.1016/0024-3205(84)90330-8

9. Дзюбайло А.В., Лотков В.С. Влияние табакокурения на акушерский анамнез женщин в период беременности. Санитарный врач. – 2020. – No2. – С. 73-77. [Dzyubajlo AV, Lotkov VS. Vliyanie tabakokureniya na akusherskij anamnez zhenshchin v period beremennosti [The influence of tobacco smoking on the obstetric history of women during pregnancy]. Sanitarnyj vrach [Sanitary doctor]. 2020; 2: 73-77. (In Russ.)].

10. Schultze A, Kurz H, Stumpflen I, Hafner E. Smoking prevalence among pregnant women from 2007 to 2012 at a tertiary-care hospital. Eur. J. Pediatr. 2016; 175(6): 833–840. DOI: 10.1007/ s00431-016-2710-1

 

UDC 616.36-004; 616-61-008.64

DOI: 10.20969/VSKM.2023.16(2).23-33

PDF download THE ROLE OF RENAL DYSFUNCTION IN FATAL OUTCOMES IN THE LIVER CIRRHOSIS

KARZAKOVA LOUISE M., ORCID ID: 0000-0002-5899-6352; SCOPUS Author ID: 56916027300, D. Med. Sci, Professor, Head of Department of Internal Diseases, Chuvash State University, 428015, Russia, Cheboksary, Moskovskii' av., 15, e-mail: luizak58@mail.ru (author for correspondence)

IVANOVA ANTONINA L., ORCID ID: 0000-0003-2054-7591; Assistant Professor of Department of Internal and Advanced Internal Medicine, Chuvash State University, 428015, Russia, Cheboksary, Moskovskii' av., 15, e-mail: ial. antonina@yandex.ru

KUDRYASHOV SERGEY I., ORCID ID: 0000-0003-2277-9425; C. Med. Sci, Associate professor, Department of Internal Diseases, Chuvash State University, 428015, Russia, Cheboksary, Moskovskii' av., 15, e-mail: medicpro21@ mail.ru

ODINTSOVA ANASTASIA V., ORCID ID: 0000-0001-7069-5029; student of the Faculty of Medicine, Chuvash State University, 428015, Russia, Cheboksary, Moskovskii' av., 15, e-mail: anastasia.od.99@mail.ru

GURIEVA AGLAIDA V., ORCID ID: 0000-0002-5862-5594; student of the Faculty of Medicine, Chuvash State University, 428015, Russia, Cheboksary, Moskovskii' av., 15, e-mail: aglaida.gur@yandex.ru

KOMELYAGINA NADEZHDA A., ORCID ID: 0000-0002-4155-4849; C. Med. Sci., Associate Professor of Department of Internal Diseases, Chuvash State University, 428015, Russia, Cheboksary, Moskovskii' av., 15; e-mail: comelya76@ mail.ru

GAVRILOVA ELVIRA S., ORCID ID: 0000-0001-6962-4266; C. Med. Sci., Associate Professor of Department of Internal Diseases, Chuvash State University, 428015, Russia, Cheboksary, Moskovskii' av., 15; e-mail: ges2201@ yandex.ru

ANISIMOVA TATIANA A., ORCID ID: 0000-0001-5687-9278; C. Med. Sci., Associate Professor of the Department of Children’s Diseases, Chuvash State University, 428015, Russia, Cheboksary, Moskovskii' av., 15; e-mail: anis2106@ yandex.ru

Abstract. Introduction. A signi cant proportion of patients hospitalized due to decompensation of liver cirrhosis have some kind of renal dysfunction (acute kidney injury, hepatorenal syndrome, chronic kidney disease). However, their e ect on mortality in cirrhosis has been little studied. Aim. The aim of the research was to study the role of renal dysfunction in fatal outcomes in cirrhosis. Material and methods. The retrospective cohort study was conducted, which included patients with a con rmed diagnosis of cirrhosis hospitalized in the hepatological department and/or the department of anesthesiology-intensive care of City Clinical Hospital No. 1 of the Ministry of Health of Chuvashia in 2014-2018. The medical histories of patients were retrospectively studied. The conclusions of pathoanatomic autopsies were analyzed in deceased patients. At the same time, demographic indicators, etiological factors of cirrhosis, the degree of compensation on the Child-Pugh scale, complications and causes of deaths were taken into account. The results of instrumental studies, laboratory tests were also considered. Particular attention was paid to the study of the frequency of occurrence of various types of renal dysfunction. Potential risk factors for death of patients were determined using a one-dimensional regression analysis. Results and discussion. During 5 years from 2014 to 2018, 634 patients with cirrhosis decompensation received inpatient treatment with a total number of hospitalizations equal to 1,672. During the rst hospitalization, 140 patients died, which is 22.1% of the total number of patients. The average age of the deceased patients was 51.4±13.6 years. Alcoholic liver disease prevailed in the etiological structure of fatal cirrhosis (in 35.7% of cases). Hospital mortality was associated in 74.2% of cases with renal dysfunction. Patients with cirrhosis decompensation died most often (26.4 %) from prerenal acute kidney injury. The fatal outcome in cirrhosis was more dependent on indicators characterizing the functional state of the kidneys (serum levels of urea, creatinine, glomerular ltration rate), the hemostasis system (prothrombin index), and to a lesser extent on indicators characterizing the functional state of the liver. Conclusion. Fatal outcomes in cirrhosis were associated in 74.2% of cases to some extent with renal dysfunction.

Key words: liver cirrhosis, lethality, hepatorenal syndrome, acute kidney injury.

For reference: Karzakova LM, Ivanova AL, Kudryashov SI, et al. The role of renal dysfunction in the fatal outcomes in liver cirrhosis. The Bulletin of Contemporary Clinical Medicine. 2023; 16(2): 23-33. DOI: 10.20969/VSKM.2023.16(2).23-33.

References

  1. Blachier M, Leleu H, Peck-Radosavljevic M, et al. The burden of liver disease in Europe: a review of available epidemiological data. J Hepatol. 2013; 58: 593–608. DOI: 10.1016/j.jhep.2012.12.005

  2. Asrani SK, Devarbhavi H, Eaton J, et al. Burden of liver diseases in the world. J Hepatol. 2019; 70(1): 151-171. DOI:10.1016/j.jhep.2018.09.014

  3. GBD 2017 Cirrhosis Collaborators. The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol Hepatol. 2020; 5(3): 245-266. DOI:10.1016/S2468-1253(19)30349-8

  4. Long B, Koyfman A. The emergency medicine evaluation and management of the patient with cirrhosis. Am J Emerg Med. 2018; 36(4): 689-698. DOI:10.1016/j. ajem.2017.12.047

  5. Simbrunner B, Trauner M, Reiberger T, Mandorfer M. Recent advances in the understanding and management of hepatorenal syndrome. Fac Rev. 2021; 10: 48. DOI:10.12703/r/10-48

  6. Choi YJ, Kim JH, Koo JK, et al. Prevalence of renal dysfunction in patients with cirrhosis according to ADQI-IAC working party proposal. Clin Mol Hepatol. 2014; 20(2): 185-191. DOI:10.3350/cmh.2014.20.2.185

  7. Huelin P, Piano S, Solà E, et al. Validation of a Staging System for Acute Kidney Injury in Patients With Cirrhosis and Association With Acute-on-Chronic Liver Failure. Clin Gastroenterol Hepatol. 2017; 15(3): 438-445.e5. DOI:10.1016/j.cgh.2016.09.156

  8. Xiong J, Pu L, Xiong H, et al. Evaluation of the criteria of hepatorenal syndrome type of acute kidney injury in patients with cirrhosis admitted to ICU. Scand J Gastroenterol. 2018; 53(12): 1590-1596. DOI:10.1080/ 00365521.2018.1545423

  9. Mindikoglu AL, Pappas SC. New Developments in Hepatorenal Syndrome [published correction appears in Clin Gastroenterol Hepatol. 2018 Jun;16(6):988]. Clin Gastroenterol Hepatol. 2018; 16(2): 162-177.e1. DOI:10.1016/j.cgh.2017.05.041

  10. Лазебник Л.Б., Голованова Е.В., Еремина Е.Ю. и др. Алкогольная болезнь печени (АБП) у взрослых // Экспериментальная и клиническая гастроэнтерология. – 2020. – Т. 174. – С. 4–28. [Lazebnik LB, Golovanova EV, Eremina EYu, et al. Alkogol’naya bolezn’ pecheni (ABP) u vzroslyh [Adult Alcoholic Liver Disease]. Eksperimental’naya i klinicheskaya gastroenterologiya [Experimental and clinical gastroenterology]. 2020; 174(2): 4–28. (In Russ.)]. DOI: 10.31146/1682-8658-ecg-174-2-4-28

  11. Reinert DF, Allen JP. The Alcohol Use Disorders Identi cation Test (AUDIT): a review of recent research. Alcohol Clin Exp Res. 2002; 26(2): 272-279.

  12. Hennes EM, Zeniya M, Czaja AJ, et al. Simpli ed criteria for the diagnosis of autoimmune hepatitis. Hepatology. 2008; 48(1): 169-176. DOI:10.1002/hep.22322

13. Лазебник Л.Б., Голованова Е.В., Туркина С.В. и др. Неалкогольная жировая болезнь печени у взрослых: клиника, диагностика, лечение. Рекомендации для терапевтов, третья версия //Экспериментальная и клиническая гастроэнтерология. – 2021. – Т. 185. – С. 4-52. [Lazebnik LB, Golovanova EV, Turkina SV, et al. Nealkogol’naya zhirovaya bolezn’ pecheni u vzroslyh: klinika, diagnostika, lechenie. Rekomendacii dlya terapevtov, tret’ya versiya [Non-alcoholic fatty liver disease in adults: clinic, diagnosis, treatment. Recommendations for therapists, third version]. Eksperimental’naya i klinicheskaya gastroenterologiya [Experimental and clinical gastroenterology]. 2021; 185: 4-52 (In Russ.)]. DOI: 10.31146/1682-8658-ecg-185-1-4-52

14. Reshetnyak VI. Primary biliary cirrhosis: Clinical and laboratory criteria for its diagnosis. World J Gastroenterol. 2015; 21(25): 7683-7708. DOI:10.3748/ wjg.v21.i25.7683

15. Angeli P, Garcia-Tsao G, Nadim MK, Parikh CR. News in pathophysiology, de nition and classi cation of hepatorenal syndrome: A step beyond the International Club of Ascites (ICA) consensus document. J Hepatol. 2019; 71(4): 811-822. DOI:10.1016/j.jhep.2019.07.002

16. Salerno F, Gerbes A, Ginès P, et al. Diagnosis, prevention and treatment of hepatorenal syndrome in cirrhosis. Postgrad Med J. 2008; 84: 662–670. DOI: 10.1136/gut.2006.107789

  1. EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis. J Hepatol. 2018; 69(2): 406-460. DOI:10.1016/j.jhep.2018.03.024

  2. Маевская М.В. Клинические особенности тяжелых форм алкогольной болезни печени. Роль вирусов гепатитов В и С //Российский журнал гастроэнтерологии, гепатологии, колопроктологии. – 2006. – T. 16, No 2. – С. 25–38. [Maevskaya MV. Klinicheskie osobennosti tyazhelyh form alkogol’noj bolezni pecheni. Rol’ virusov gepatitov V i C [Clinical features of severe forms of alcoholic liver disease. The role of hepatitis B and C viruses]. Rossijskij zhurnal gastroenterologii, gepatologii, koloproktologii [Russian Journal of Gastroenterology, Hepatology, Coloproctology]. 2006; 16(2): 25-38. (In Russ.)]

  3. Naveau S, Perlemuter G, Balian A. Epidémiologie et histoire naturalle de la cirrhose [Epidemiology and natural history of cirrhosis]. Rev Prat. 2005; 55(14):1527-1532.

  4. Liaw YF, Kao JH, Piratvisuth T, et al. Asian-Paci c consensus statement on the management of chronic hepatitis B: a 2012 update. Hepatol Int. 2012; 6(3): 531-561. DOI:10.1007/s12072-012-9365-4

  5. Lazo M, Hernaez R, Bonekamp S, et al. Non-alcoholic fatty liver disease and mortality among US adults: prospective cohort study. BMJ. 2011; 343: d6891. DOI: 10.1136/bmj.d6891

22. Desai AP, Knapp SM, Orman ES, et al. Changing epidemiology and outcomes of acute kidney injury in hospitalized patients with cirrhosis – a US population-based study. J Hepatol. 2020; 73(5): 1092-1099. DOI: 10.1016/j.jhep.2020.04.043.

23. Alavi M, Janjua NZ, Chong M, et al. The contribution of alcohol use disorder to decompensated cirrhosis among people with hepatitis C: An international study. J Hepatol. 2018; 68(3): 393-401. DOI:10.1016/j.jhep.2017.10.019

24. Gupta K, Bhurwal A, Law C, et al. Acute kidney injury and hepatorenal syndrome in cirrhosis. World J Gastroenterol. 2021; 27(26): 3984-4003. DOI:10.3748/ wjg.v27.i26.3984

25. Belcher JM, Sanyal AJ, Peixoto AJ, et al. Kidney biomarkers and di erential diagnosis of patients with cirrhosis and acute kidney injury. Hepatology. 2014; 60(2): 622-632. DOI:10.1002/hep.26980

26. Huang Y, Cai J, Ha F, et al. Characteristics of acute kidney injury and its impact on outcome in patients with acute-on-chronic liver failure. BMC Gastroenterol. 2022; 22(1): 231. DOI:10.1186/s12876-022-02316-8

27. Garcia-Tsao G, Parikh CR, Viola A. Acute kidney injury in cirrhosis. Hepatology. 2008; 48: 2064–2077.

28. Planas R, Montoliu S, Balleste B, et al. Natural history of patients hospitalized for management of cirrhotic ascites. Clin Gastroenterol Hepatol. 2006; 4: 1385–1394.

 

UDC 616.24-008.46:613.84

DOI: 10.20969/VSKM.2023.16(2).34-38

PDF download FORECASTING THE PROBABILITY OF COPD DEVELOPMENT DEPENDING ON THE SMOKING EXPERIENCE OF WOMEN OF FERTILE AGE

LOTKOV VYACHESLAV S., ORCID ID: 0000-0002-3995-6988, D. Med. Sci. professor of the Department of Occupational Diseases and Clinical Pharmacology named after professor V.V. Kosarev of Samara State Medical University, Russia, 443099, Samara, Chapaevskaya str., 89, e-mail: v.s.lotkov@gmail.com

DZYUBAILO ANNA V., ORCID ID: 0000-0001-6908-4829, C. Med. Sci., associate professor, Head of the Department of Internal Medicine with a Course of Outpatient Treatment and Hemotransfusiology of Samara State Medical University, Russia, 443099, Samara, Chapaevskaya St., 89, e-mail: adzyubajlo@yandex.ru

Abstract. Introduction. The article presents the results of assessing the likelihood of developing chronic obstructive pulmonary disease, depending on the history of smoking and the number of cigarettes smoked per day by women of fertile age. Aim. The aim is to establish the probability and degree of in uence of nicotine addiction on the formation of chronic obstructive pulmonary disease in women of fertile age. Material and methods. А cohort of 107 smoking women of fertile age with varying degrees of nicotine dependence observed was studied: 53 patients are active smokers exposed to passive smoking at home ( rst group 1), 54 patients are active smokers without passive smoking (group 2). The control group - 42 non-smoking women who do not have chronic diseases. The reliability of the results was evaluated using nonparametric statistical methods (Statistica 10, Microsoft Excel 2010). Results and discussion. With smoking experience in the range from one year to ten years in the second group, the probability of chronic obstructive pulmonary disease formation develops more slowly compared to that in the rst group. This di erence in probabilities is gradually decreasing from year to year. With ten years of smoking experience, the probabilities of chronic obstructive pulmonary disease in both groups become equal, and then the situation changes to the opposite. In the rst group, the probability of chronic obstructive pulmonary disease begins to develop more slowly compared to the second group. The di erence in probabilities is gradually decreasing from year to year, practically comparing with the smoking experience of twenty-two years.Conclusion. Passive smoking, in addition to active smoking, increases the nicotine load with the formation of more pronounced prerequisites for the pathogenetic processes of chronic obstructive pulmonary disease development. The probability of chronic obstructive pulmonary disease development in the second group decreases and it is possible that it is the number of cigarettes (from 10 to 16 cigarettes per day) more than passive smoking that is the main factor in the development of the disease. When overcoming the 11-year interval, regardless of the absence of passive smoking, the predominant factor is the smoking experience of 20 or more years.

Keywords: women of fertile age, degree of nicotine dependence.

For reference: Lotkov VS, Dzyubailo AV, Forecasting the probability of COPD development depending on the smoking experience of women of fertile age. The Bulletin of Contemporary Clinical Medicine. 2023; 16(2): 34-38. DOI: 10.20969/VSKM.2023.16(2).34-38.

References

  1. Kohansal R, Martinez-Camblor P, Agusti A, et al. The natural history of chronic air ow obstruction revisited: an analysis of the Framingham o spring cohort. Am J RespirCrit Care Med 2009;180; 3-10. DOI: 10.1164/ rccm.200901-0047OC

  2. Global strategy for the diagnosis, management, and prevention of Chronic Obstructive Pulmonary Disease, 2015.

  3. Qureshi H., Sharafkhaneh A., Hanania N.A. Еxacerbations: latest evidence and clinical implications. Ther. Adv. Chronic. Dis. 2014. Vol. 5(5). 212—227. DOI: 10.1177/2040622314532862

  4. Death from tobacco. In: WHO Regional O ce for Europe [website]. Copenhagen: WHO Regional O ce for Europe; 2013 (http://www.euro.who.int/en/health-topics/ diseaseprevention/ tobacco/data-and-statistics/death-from-tobacco, accessed 31 October2013).

  5. Raad D, Gaddam S, Schunemann HJ, et al. E ects of water-pipe smoking on lung function: a systematic review and meta-analysis. Chest. 2011;139; 764-74. DOI: 10.1378/chest.10-0991

  6. Антонов В.Н., Игнатова Г.Л., Родионова О.В., и др. Табакокурение и функциональное состояние респираторной системы у больных с хронической обструктивной болезнью легких. Сибирское медицинское обозрение. — 2014. — No 6 (90). — С. 75-78. [Antonov VN, Ignatova GL, Rodionova OV, Grebneva IV, Blinova EV, Pustovalova IA. Tabakokurenie i funkcional'noe sostoyanie respiratornoj sistemy u bol'nyh s hronicheskoj obstruktivnoj bolezn'yu legkih [Tobacco smoking and the functional state of the respiratory system in patients with chronic obstructive pulmonary disease]. Sibirskoe medicinskoe obozrenie [SiberianMedical Review]. 2014; 6 (90): 75-78. (In Russ.)].

  7. Сахарова Г.М., Антонов Н.С. Табакокурение и репродуктивная функция женщин. РМЖ. Мать и дитя. — 2013. — No1. — С. 12-20. [Saharova GM, Antonov NS. Tabakokurenie i reproduktivnaya funkciya zhenshchin [Tobacco smoking and the reproductive function of women]. RMZH. Mat' i ditya [RMZH. Motherandchild]. 2013; 1: 12-20. (In Russ.)].

  8. Герасименко Н.Ф., Заридзе Д.Г., Сахарова Г.М. Здоровье и табак. М.: Форум «Здоровье или табак», 2007. [Gerasimenko NF, Zaridze DG, Saharova GM. Zdorov'e i tabak [Health and tobacco]. Forum «Zdorov'e ili tabak» [Forum «Health and tobacco»]. 2007. (In Russ.)].

  9. Чучалин А.Г. Российское респираторное общество. Федеральные клинические рекомендации по диагностике и лечению хронической обструктивной болезни легких. Пульмонология. — 2014. — No 3. — С.15—54. [CHuchalin AG. Rossijskoe respiratornoe obshchestvo. Federal'nye klinicheskie rekomendacii po diagnostike i lecheniyu hronicheskoj obstruktivnoj bolezni legkih [Russian Respiratory Society. Federal clinical guidelines for the diagnosis and treatment of chronic obstructive pulmonary disease]. Pul'monologiya [Pulmonology]. 2014; 3: 15—54. (In Russ.)].

  10. Lamprecht B, McBurnie MA, Vollmer WM, et al. BOLD Collaborative Research Group: COPD in never smokers: results form the population-based burden of obstructive lung disease study. Chest 2011; 139: 752–763. (http:// www.goldcopd.com)

 

UDC 616-071.1-044.3:616-008

DOI: 10.20969/VSKM.2023.16(2).39-48

PDF download DEVELOPMENT OF A SIMPLE QUESTIONNAIRE FOR EARLY DETECTION OF PREMORBID FUNCTIONAL HEALTH IMPAIRMENTS

MARTYUSHEV-POKLAD ANDREY V., ORCID ID: 0000-0002-1193-1287; Scopus Author ID: 8278501900, Researcher ID: AAD-2072-2022; C. Med. Sci., Senior Researcher, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitation, Russia 107031 Moscow Petrovka street, 25 bld 2; e-mail: avmp2007@gmail.com

YANKEVICH DMITRY S., ORCID ID: 0000-0001-5143-7366; Scopus Author ID: 57192693303; ResearcherID: AAG-1392-2020; C. Med. Sci., Laboratory Head, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitation, Russia 107031 Moscow Petrovka street, 25 bld 2; e-mail: yanson_d@mail.ru

SAVITSKAYA NATALIYA G., ORCID ID: 0000-0001-8674-1632; ResearcherID: AAH-4702-2021, Scopus Author ID: 35773664800; C. Med. Sci., Senior Researcher, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitation, Russia 107031 Moscow Petrovka street, 25 bld 2; e-mail: elirom@mail.ru

GRECHKO ANDREY V., ORCID ID: 0000-0003-3318-796X, Scopus author ID: 57194278611, ResearcherID: C-8208-2018, Director, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitation, Russia 107031 Moscow Petrovka street, 25 bld 2; e-mail: fnkcrr@fnkcrr.ru

Abstract. Introduction. Health systems and health status in developed economies demonstrate failure of chronic disease prevention, in part due to too late health interventions postponed until the patient has a medical diagnosis. Healthcare system can bene t from P4 medicine, which needs special questionnaires to collect person-centered data. The available questionnaires do not match the practical tasks of the P4-medicine paradigm. Aim. The aim is to develop a simple questionnaire for mass early screening of health status in the adults within the P4-medicine paradigm.Material and Methods. We transformed and adapted the Suboptimal health status questionnaire (SHSQ-25) to meet the requirements of mass screening in the P4 medicine paradigm. Information value, sensitivity and speci city of the new questionnaire were tested in several focus groups of respondents through matching with detailed clinical interview aimed at prevention of chronic health conditions. Results and discussion. The Functional impairment questionnaire “FIQ-15” includes 15 questions covering the most common warning symptoms seen in respondents of various health states. Two alternative scales, 5-point and 3-point, are proposed to rate the symptoms. Based on the rate of functional impairments, their impact on everyday functioning, and the need in detailed examination and/or help, respondents are divided into 4 risk groups. More than 400 respondents lled the FIQ-15 over 2 years, 300 of them underwent detailed clinical interviews for questionnaire development and validation. The system of data acquisition and interpretation based on FIQ-15 allows automated mass screening for early functional impairments, fast primary sorting into risk groups (‘tra c light’ system), semi-quantify the severity of functional impairments and their impact on life quality, propose e ective routing of patients to further examination and diagnosing, and involve the respondent in active management of one’s health. Conclusion. The proposed FIQ-15 questionnaire can become a simple, a ordable and informative tool in early mass screening for functional impairments in the P4-medicine paradigm, in sorting the respondents based on their need in detailed examination, and in real life decision support, including the respondent’s participatory decisions regarding one’s health management.

Key words: questionnaire, early screening, premorbid functional impairment, prevention, P4 medicine

For reference: Martyushev-Poklad AV, Yankevich DS, Savitskaya NG, Grechko AV. Development of a simple questionnaire for early detection of premorbid functional health impairments. The Bulletin of Contemporary Clinical Medicine. 2023; 16(2): 39-48. DOI: 10.20969/VSKM.2023.16(2).39-48.

References

  1. Оказание медицинской помощи взрослому населению в Центрах здоровья : Методические рекомендации / О. В. Кривонос, С. А. Бойцов, Н. В. Погосова [и др.]. – М., 2012. – 110 с. [Okazanie medicinskoj pomoshchi vzroslomu naseleniyu v Centrah zdorov’ya : Metodicheskie rekomendacii [Provision of medical care to the adult population in Health Centers : Methodological recommendations] Krivonos OV, Boytsov SA, Pogosova NV, et al. Moscow, 2012, 110 p. (in Russ.)].

  2. Организация проведения профилактического медицинского осмотра и диспансеризации определенных групп взрослого населения: Методические рекомендации / Ред. Драпкина О.М., Дроздова Л.Ю. М., 2019. – 165 с. Прил.1. [Organizaciya provedeniya pro lakticheskogo medicinskogo osmotra i dispanserizacii opredelennyh grupp vzroslogo naseleniya : Metodicheskie rekomendacii. [Organization of preventive medical examination and health checkups of certain groups of the adult population: Methodological recommendations] Drapkina OM, Drozdova LYu (Editors). Moscow, 2019, 165 p., Suppl.1 (in Russ.)].

  3. Martyushev-Poklad A, Yankevich D, Petrova M. Improving the E ectiveness of Healthcare: Diagnosis-Centered Care Vs Person-Centered Health Promotion, a Long Forgotten New Model. Front Public Health 2022 May 16; 10:819096. DOI: 10.3389/fpubh.2022.819096

  4. Porter ME. What is value in health care? N Engl J Med 2010 Dec 23;363(26):2477-81. DOI: 10.1056/ NEJMp1011024

  5. Field J, Holmes MM, Newell D. PROMs data: can it be used to make decisions for individual patients? A narrative review. Patient Relat Outcome Meas 2019; 10:233-241. DOI: 10.2147/PROM.S156291

  6. Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 1992 Jun;30(6):473-83.

  7. Trell E. «HealthOmeter»: An Aid in Advancing Preventive Medicine Media Revolution. Adv Prev Med 2015;2015:798971. DOI: 10.1155/2015/798971

  8. Yan YX, Liu YQ, Li M, et al. Development and evaluation of a questionnaire for measuring suboptimal health status in urban Chinese. J Epidemiol 2009;19(6):333-41. DOI: 10.2188/jea.je20080086

  9. Купаев В. И., Марутина Е. Ю., Борисов О. Ю. Чувствительность метода оценки субоптимального статуса здоровья с помощью опросника SHSQ-25 // Вестник современной клинической медицины. – 2014. – Т. 7. – No 2. – С. 18-21. [Kupaev VI, Marutina EYu, Borisov OYu. Chuvstvitel’nost’ metoda ocenki suboptimal’nogo statusa zdorov’ya s pomoshch’yu oprosnika SHSQ-25 [Sensitivity estimates of suboptimal health status using SHSQ-25 questionnaire] Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Contemporary Clinical Medicine] 2014; 7(2): 18-21 (in Russ.)].

  10. Bevans M, Ross A, Cella D. Patient-Reported Outcomes Measurement Information System (PROMIS): e cient, standardized tools to measure self-reported health and quality of life. Nurs Outlook 2014;62(5):339-345. DOI:10.1016/j.outlook.2014.05.009

  11. Мартюшев-Поклад А.В., Янкевич Д.С., Пантелеев С.Н. и др. Состояние классических средств информатизации здравоохранения и организационная модель медицинской помощи: возможности для развития // Врач и информационные технологии. - 2020. - No S5. - С. 6-16. [Martyushev-Poklad AV, Yankevich DS, Panteleev SN, et al. Sostoyanie klassicheskih sredstv informatizacii zdravoohraneniya i organizacionnaya model’ medicinskoj pomoshchi: vozmozhnosti dlya razvitiya [Healthcare information systems and organizational model of care: current situation and opportunities for progress] Vrach i informacionnye tekhnologii [Medical Doctor and IT] 2020; S5: 6-16. (in Russ.)] DOI: 10.37690/1811-0193- 2020-5-6-16

  12. Mezzich J. 2014 Geneva Declaration on Person- and People-centered Integrated Health Care for All. International Journal of Person Centered Medicine 2014; 4(2): 66-68.

  13. Таратухин Е.О. Пациент-центрированная медицина. Новая реальность // Российский кардиологический журнал. – 2016. – Т.21 - No9. – С.79–83. [Taratukhin EO. Pacient-centrirovannaya medicina. Novaya real’nost’ [Patient-centered medicine. A new reality] Rossijskij kardiologicheskij zhurnal [Russian Journal of Cardiology] 2016; 21(9): 79-83 (in Russ.)]. DOI:10.15829/1560-4071-2016-9-79-83

  14. Исследование в психологии: методы и планирование / Дж. Гудвин. — 3-е изд. — СПб.: Питер, 2004. — 558 с. [Goodwin CG. Research in Psychology. Methods and Design. 3rd ed., Piter, S-Petersburg, 558 p. (in Russ.)].

 

UDC:616.127-005.8-06-036.88:616.24-007.272-036.12

DOI: 10.20969/VSKM.2023.16(2).49-55

PDF download PROGNOSIS OF SIGNIFICANT ISCHEMIC EVENTS AND LETHAL OUTCOME IN PATIENTS WITH MYOCARDIAL INFARCTION WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

PROKOFYEVA TATIANA V., ORCID ID: 0000-0002-3260-2677; C. Med. Sci., associate professor of the Internal Medicine Department of Pediatric Department, Astrakhan State Medical University, Astrakhan, 54-170 Pobedy St., 414040, Russia, Astrakhan, e-mail: prokofeva-73@inbox.ru

POLUNINA OLGA S., ORCID ID: 0000-0001-8299-6582, D. Med. Sci., Professor, Head of Internal Medicine Department of Pediatric Department, Astrakhan State Medical University, 414000, Russia, Astrakhan, Bakinskaya str. 121, e-mail: admed@yandex.ru

POLUNINA EKATERINA A., ORCID ID: 0000-0002-3679-432X, D. Med. Sci., associate professor of the Internal Medicine Department of Pediatric Department, Astrakhan State Medical University, Astrakhan, 414000, Russia, Astrakhan, Bakinskaya str. 121, e-mail: gilti2@yandex.ru

Abstract. Introduction. Myocardial infarction remains signi cant due to its high prevalence and disability. Of particular importance is the prediction of the risk of adverse events in myocardial infarction patients with cardiorespiratory comorbidity, in particular with chronic obstructive pulmonary disease. It can be assumed that endogenous intoxication syndrome can be considered as a predictor of life-threatening events (repeated myocardial infarction, stroke) and lethal outcome in patients with myocardial infarction against chronic obstructive pulmonary disease. Aim. The aim is to determine the probability of combined endpoint development (repeated myocardial infarction, stroke, lethal outcome) in patients with myocardial infarction against chronic obstructive pulmonary disease during 12-month follow-up depending on gender-anamnestic and clinical-functional characteristics. Material and methods. We examined 325 patients with myocardial infarction - 195 patients with myocardial infarction against chronic obstructive pulmonary disease and 130 patients with myocardial infarction without chronic obstructive pulmonary disease (comparison group). As markers of endogenous intoxication syndrome, we studied middle weight molecules, hematological intoxication indices, blood gas indices, apoptosis, protein and lipid peroxidation and antioxidant protection, in ammation and renal function. Statistical data processing was performed using SPSS 26.0 software package. Results and discussion. Two-stage cluster analysis resulted in four clusters characterizing the type of endogenous intoxication syndrome: «polymarker-retentive», «necrotic- in ammatory», «hypoxic-in ammatory» and a cluster with no endogenous intoxication syndrome. The polymarker- retentive type of endogenous intoxication syndrome prevailed among patients with myocardial infarction against chronic obstructive pulmonary disease. Recurrent myocardial infarction, stroke and mortality constituted the combined endpoint. A decision tree was constructed to determine the probability of developing the combined endpoint in patients with myocardial infarction against the background of chronic obstructive pulmonary disease during the 12-month follow-up. It was found that the most signi cant predictors of combined endpoint occurrence are polymarker-retentive type of endogenous intoxication syndrome, the presence of acute infarction period complications and pronounced bronchoobstruction (degree 3-4). Conclusion. The constructed decision tree allows to stratify patients with high risk of repeated infarction, stroke and lethal outcome during the rst year of follow-up after myocardial infarction against chronic obstructive pulmonary disease without increasing economic costs, which promotes optimization of treatment and secondary prevention in this category of patients.

Keywords: myocardial infarction, chronic obstructive pulmonary disease, cardiorespiratory comorbidity, endogenous intoxication syndrome, decision tree.

For reference: Prokofyeva TV, Polunina OS, Polunina EA Prognosis of signi cant ischemic events and lethal outcome in patients with myocardial infarction against chronic obstructive pulmonary disease. The Bulletin of Contemporary Clinical Medicine. 2023; 16(2): 49-55. DOI: 10.20969/VSKM.2023.16(2).49-55.

References

  1. Шишкина Е.А., Хлынова О.В., Черемных А.Б. Прогнозирование постгоспитальной летальности у больных инфарктом миокарда молодого и среднего возраста // Доктор.Ру. – 2020. – Т. 19, вып. 5. – С.24–29. [SHishkina EA, Hlynova OV, CHeremnyh AB. Prognozirovanie postgospital'noj letal'nosti u bol'nyh infarktom miokarda molodogo i srednego vozrasta [Prediction of posthospital mortality in young and middle-aged myocardial infarction patients]. Doktor. Ru [Doktor.Ru]. 2020; 19 (5): 24–29. (In Russ.)]. DOI: 10.31550/1727-2378-2020-19-5-24-29
  2. Shah NS, Hu man MD, Ning H, Lloyd-Jones DM. Trends in myocardial infarction secondary prevention: The National Health and Nutritional Examination Survey (NHANES), 1999–2012. J Am Heart Assoc. 2015; 4 (4): pii:e001709.
  3. Jernberg T, Hasvold P, Henriksson M, et al. Cardiovascular risk in postmyocardial infarction patients: nationwide real world data demonstrate the importance of longterm perspective. Eur Heart J. 2015; 36 (19): 1163–70.
  4. Жмуров Д.В., Парфентева М.А., Семенова Ю.В. Инфаркт миокарда // Colloquium-Journal. – 2020. – Т.31, вып. 1(83). – С. 56-61. [Zhmurov DV, Parfenteva MA, Semenova YuV. Infarkt miokarda [Myocardial infarction]. Colloquium-Journal. 2020; 31.1(83): 56-61. (In Russ.)]. DOI: 10.24412/2520-2480-2020-3183-55-60
  5. Зафираки В.К., Космачева Е.Д., Мирзаев С.Г., и др. Хроническая обструктивная болезнь легких у больных ишемической болезнью сердца ухудшает отдаленный прогноз после чрескожных коронарных вмешательств // Кардиология. – 2021. – Т. 61, вып. 11. – С.24–32. [Za raki VK, Kosmacheva ED, Mirzaev SG, i dr. Hronicheskaya obstruktivnaya bolezn' legkih u bol'nyh ishemicheskoj bolezn'yu serdca uhudshaet otdalennyj prognoz posle chreskozhnyh koronarnyh vmeshatel'stv [Chronic obstructive pulmonary disease in patients with coronary heart disease worsens long-term prognosis after percutaneous coronary interventions]. Kardiologiya [Cardiology]. 2021; 61 (11): 24–32. (In Russ.)]. DOI: 10.18087/cardio.2021.11. n1820

  1. Григорьева Н.Ю., Майорова М.В., Королёва М.Е., Самолюк М.О. Особенности формирования и развития сердечно-сосудистых заболеваний у больных хронической обструктивной болезнью легких // Терапевтический архив. – 2019. – Т. 91, вып. 1. – С.16-47. [Grigor'eva NY, Majorova MV, Korolyova ME, Samolyuk MO. Osobennosti formirovaniya i razvitiya serdechno-sosudistyh zabolevanij u bol'nyh hronicheskoj obstruktivnoj bolezn'yu legkih [Peculiarities of formation and development of cardiovascular diseases in patients with chronic obstructive pulmonary disease]. Terapevticheskij arhiv [Therapeutic Archive]. 2019; 91 (1): 16–47. (In Russ.)]. DOI: 10.26442/00403660.201 9.01.000027

  2. Полунина О.С., Уклистая Т.А., Полунина Е.А. Распространенность коморбидного сочетания хронической обструктивной болезни легких и сердечно-сосудистой патологии по данным ретроспективного анализа // Астраханский медицинский журнал. – 2018. – Т. 13, вып. 2. – С.90–96. [Polunina OS, Uklistaya TA, Polunina EA. Rasprostranennost' komorbidnogo sochetaniya hronicheskoj obstruktivnoj bolezni legkih i serdechno-sosudistoj patologii po dannym retrospektivnogo analiza [Prevalence of comorbid combination of chronic obstructive pulmonary disease and cardiovascular pathology according to retrospective analysis]. Astrahanskij medicinskij zhurnal [Astrakhan Medical Journal]. 2018; 13 (2): 90-96. (In Russ.)].

  3. Барбараш О.Л., Седых Д.Ю., Горбунова Е.В. Основные факторы, определяющие риск развития повторного инфаркта миокарда // Сердце: журнал для практикующих врачей. – 2017. – Т. 16, вып. 1. – С.10-50. [Barbarash OL, Sedyh DY, Gorbunova EV. Osnovnye faktory, opredelyayushchie risk razvitiya povtornogo infarkta miokarda [The main factors determining the risk of recurrent myocardial infarction]. Serdce: zhurnal dlya praktikuyushchih vrachej [The Heart: A Journal for Practitioners]. 2017; 16 (1): 10-50. (In Russ.)] DOI: 10.18087/rhj.2017.1.2280

  4. Митьковская Н.П., Пинчук А.Ф., Павлович Т.П., и др. Прогнозирование неблагоприятных исходов у пациентов с постинфарктным кардиосклерозом // Кардиология в Беларуси. – 2015. – Т. 5, вып. 42. – С. 44-50. [Mitkovskaya NP, Pinchuk AF, Pavlovitch TP, et al. Prognozirovanie neblagopriyatnyh iskhodov u pacientov s postinfarktnym kardiosklerozom [Prediction of adverse outcomes in patients with postinfarction cardiosclerosis]. Kardiologiya v Belarusi [Cardiology in Belarus]. 2015; 5 (42): 44-50. (In Russ)] eLIBRARY ID: 25134637

  5. Новикова Р.А., Алексейчик С.Е., Гончарик Т.А., и др. Повторный инфаркт миокарда, причины его развития, трудности диагностики и профилактика // Экстренная медицина. – 2017. – Т. 6, вып. 2. – С. 229-234. [Novikova RA, Alekseichik SE, Goncharik TA, et al. Povtornyj infarkt miokarda, prichiny ego razvitiya, trudnosti diagnostiki i pro laktika [Recurrent myocardial infarction, causes of its development, diagnostic di culties and prevention]. Ekstrennaya medicina [Emergency Medicine]. 2017; 6 (2): 229-234. (In Russ.)] eLIBRARY ID: 29120607

  6. Золотавина М.Л., Пашина Е.В. Современные методологические проблемы оценки эндогенной интоксикации // Наука и мир. – 2014. – Т. 11, вып. 15. С.38-41. [Zolotavina ML, Pashina EV. Sovremennye metodologicheskie problemy ocenki endogennoj intoksikacii [Modern problems of science and education]. Nauka i mir [Science and World]. 2014; 11 (15): 38-41. (In Russ)].

  7. Пашина Е.В., Золотавина М.Л. Комплекс биохимических показателей в оценке формирования стадий эндогенной интоксикации в клетке // Современные проблемы науки и образования. – 2019. – No 6. [Pashina EV, Zolotavina ML. Kompleks biohimicheskih pokazatelej v ocenke formirovaniya stadij endogennoj intoksikacii v kletke [Complex of biochemical indices in the assessment of the formation of stages of endogenous intoxication in a cell]. Sovremennye problemy nauki i obrazovaniya [Modern problems of science and education]. 2019; 6. URL: https:// science-education.ru/ru/article/view?id=29437 (data obrashcheniya: 09.12.2021). (In Russ.)].

  8. Четвертое универсальное определение инфаркта миокарда. – 2018. [Chetvertoe universal'noe opredelenie infarkta miokarda [The fourth universal de nition of myocardial infarction]. 2018. (In Russ.)]. URL: https://russjcardiol.elpub.ru/jour/article/ viewFile/3259/2531

  9. Global Initiative for Chronic Obstructive Lung Disease. 2022; 177 p. URL: GOLD-REPORT-2022-v1.1-22Nov2021_WMV.pdf

  10. Воронцова Н.Л., Богданов М.В., Головкин А.С., Григорьев Е.В. Эндогенная интоксикация у больных ИБС до и после коронарного шунтирования. Эфферентная терапия. – 2011. – Т. 17, вып. 4. – С. 68-74. [Vorontsova NL, Bogdanov MV, Golovkin AS, Grigoriev EV. Endogennaya intoksikaciya u bol'nyh IBS do i posle koronarnogo shuntirovaniya [Endogenous intoxication in CHD patients before and after coronary bypass grafting]. E erentnaya terapiya [E erent Therapy]. 2011; 17 (4): 68-74. (In Russ.)].

  11. Афанасьева А.Н., Демьянов С.В., Репин А.Н., и др. Лабораторная оценка эндогенной интоксикации у больных инфарктом миокарда // Российский кардиологический журнал. – 2007. – Т. 12, вып. 3. –С. 36-40. [Afanasyeva AN, Demyanov SV, Repin AN, et al. Laboratornaya ocenka endogennoj intoksikacii u bol'nyh infarktom miokarda [Laboratory evaluation of endogenous intoxication in patients with myocardial infarction]. Rossijskij kardiologicheskij zhurnal [Russian Journal of Cardiology]. 2007; 12 (3): 36-40. (In Russ.)].

 

UDC: 616-053.9

DOI: 10.20969/VSKM.2023.16(2).56-63

PDF download THE ROLE OF LEPTIN IN VARIOUS AGE-ASSOCIATED PATHOLOGIES IN OLD AGE AND IN LONG-LIVERS

TOPOLYANSKAYA SVETLANA V., ORCID ID: 0000-0002-4131-8432; C. Med. Sci., associate professor, Department of Advanced Internal Medicine N2, First Moscow State Medical University, Russia, 119991, Moscow, Trubetskaya str., 8/2; general practitioner of War Veterans Hospital N3, Russia, 129336, Moscow, Startovaya str., 4, e-mail: sshekshina@yandex.ru

MАMCHICH DARYA S., ORCID ID: 0000-0003-3331-4033; student, First Moscow State Medical University,  Russia, 119991, Moscow, Trubetskaya str., 8/2; e-mail: dasha.mamchich@gmail.com

ELISEEVA TATYANA A., ORCID ID: 0000-0002-6921-0589; geriatrician of War Veterans Hospital N3, Russia, 129336, Moscow, Startovaya str., 4, e-mail: eliseet@yandex.ru

VAKULENKO OLGA N., ORCID ID: 0000-0002-4139-5075; The head of 6 geriatric department of War Veterans Hospital N3, Russia, 129336, Moscow, Startovaya str., 4, e-mail: onv.62@mail.ru

RATCHINA SVETLANA A., ORCID ID: 0000-0002-3329-7846; D. Med. Sci., Professor, The head of Department of Advanced Internal Medicine N2, First Moscow State Medical University, Russia, 119991, Moscow, Trubetskaya str., 8/2; e-mail: svetlana.ratchina@antibiotic.ru

DVORETSKI LEONID I., ORCID ID: 0000-0003-3186-0102; D. Med. Sci., Professor, Professor of Department of Advanced Internal Medicine, First Moscow State Medical University, Russia, 119991, Moscow, Trubetskaya str., 8/2; e-mail: dvoretski@mail.ru

LYTKINA KARINA A., ORCID ID: 0000-0001-9647-7492; C. Med. Sci., Deputy Chief Physician of War Veterans Hospital N3, Russia, 129336, Moscow, Startovaya str., 4, e-mail: lytkina.k@mail.ru

MELKONYAN GEORGYI G., ORCID ID: 0000-0002-4021-5044; D. Med. Sci., Chief Physician of War Veterans Hospital N3, Russia, 129336, Moscow, Startovaya str., 4, e-mail: gvv3@zdrav.mos.ru

Abstract. Introduction. Leptin is an adipokine synthesized by adipose tissue. This substance is involved in the development of some age-related pathological conditions. Aim. Determination of leptin concentration and analysis of the relationship of this adipokine with obesity and other pathological conditions in elderly patients and centenarians.Material and methods. This work was a cross-sectional study. 110 very elderly patients and centenarians were enrolled in the study: 90 with coronary artery disease – in the study group, 20 without coronary artery disease– in the control group. The mean age of study patient was 88.5+4.5 years. The serum leptin concentration was determined by enzyme-linked immunosorbent assay. Normal leptin values for women were 2.6-11.1 ng/ml, for men – 2.0-5.6 ng/ml.Results and discussion. Elevated leptin levels were found in 58.2% of patients, decreased – in 16.4%, normal – in 25.4%. In patients with coronary artery disease the mean concentration of leptin reached 16.7 ng/ml, in patients without coronary artery disease– 15.3 ng/ml (p=0.6). In patients with chronic heart failure the probability of detecting low leptin levels increased by 3.2 times, compared with patients without heart failure (OR=3.2; 95% CI=1.1-9.9; p=0.03). In patients with obesity the mean leptin level was 28.5 ng/ml, while in patients without obesity – 12.2 ng/ml (p=0.00002). The signi cant correlation was found between the leptin concentration and body mass index (p<0.000001), as well as fat mass (p=0.000001). Higher leptin levels were observed in patients with diabetes mellitus (26.3 ng/ml vs 13.5 ng/ml in patients without diabetes mellitus, p=0.0003). In patients with low leptin concentration lower bone mineral density was registered (p=0.0003). Conclusion. The study results suggest frequent leptin pathology in very elderly patients and centenarians, both with and without coronary artery disease. Higher leptin levels are associated with various metabolic disorders. Lower leptin levels are typical for patients with chronic heart failure.

Keywords: leptin, fat, obesity, coronary artery disease, old age, centenarians.

For reference: Topolyanskaya SV, Mamchich DS, Eliseeva TA, et al. The role of leptin in various age-associated pathologies in old age and in long-livers. The Bulletin of Contemporary Clinical Medicine. 2023; 16(2): 56-63. DOI: 10.20969/VSKM.2023.16(2).56-63.

References

  1. Chapman IM. Obesity Paradox during Aging. Interdiscipl Top Gerontol. 2010; 37: 20-36. DOI: 10.1159/000319992

  2. Isidori A, Strollo F, Morè M, et al. Leptin and Aging: Correlation with Endocrine Changes in Male and Female Healthy Adult Populations of Di erent Body Weights. J Clin Endocrinol Metab. 2000; 85 (5): 1954-1962. DOI: 10.1210/jcem.85.5.6572

  3. Pérez L, Pareja-Galeano H, Sanchis-Gomar F, et al. ‘Adipaging’: ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue. J Physiol (Lond). 2016; 594 (12): 3187-3207. DOI: 10.1113/jp271691

  4. Dardeno T, Chou S, Moon H, et al. Leptin in human physiology and therapeutics. Front Neuroendocrinol. 2010; 31 (3): 377-393. DOI: 10.1016/j.yfrne.2010.06.002

  5. Chen M-C, Hsu B-G, Lee C-J, Wang J-H. Hyperleptinaemia positively correlates with cardiometabolic syndrome in hypertensive patients. Int J Clin Exp Pathol. 2016; 9 (12): 12959-12967.

  6. Roszkowska-Gancarz M, Jonas M, Owczarz M, et al. Age-related changes of leptin and leptin receptor variants in healthy elderly and long-lived adults. Geriatr Gerontol Int. 2014; 15 (3): 365-371. DOI: 10.1111/ ggi.12267

  7. Lana A, Valdés-Bécares A, Buño A, Rodríguez-Artalejo F, Lopez-Garcia E. Serum Leptin Concentration is Associated with Incident Frailty in Older Adults. Aging Dis. 2017; 8 (2): 240. DOI: 10.14336/ad.2016.0819

  8. Chai S, Sun F, Nie X, Wang J. Leptin and coronary heart disease: A systematic review and meta-analysis. Atherosclerosis.2014;233(1):3-10. DOI:10.1016/j. atherosclerosis.2013.11.069

  9. Picard F, Carter S, Caron A, Richard D. Role of leptin resistance in the development of obesity in older patients. Clin Interv Aging. 2013; 8: 829-844. DOI: 10.2147/cia.s36367

  10. Al Maskari MY, Alnaqdy AA. Correlation between serum leptin levels, body mass index and obesity in Omanis. Sultan Qaboos Univ Med J. 2006; 6 (2): 27–31.

  11. Njelekela M, Kuga S, Hiraoka J, et al. Determinants of hyperleptinaemia in an African population. East Afr Med J. 2004; 80 (4). DOI: 10.4314/eamj.v80i4.8641

  12. Bottner A. Serum leptin levels in heart failure patients may be altered di erently according to clinical stage. Eur Heart J. 2000; 21 (4): 334-335. DOI: 10.1053/ euhj.1999.1979

  13. New insights in bone metabolism in elderly female with osteoporosis-the role of leptin. [Accessed August 26, 2022]. https://www.revistagalenus.ro/practica- medicala/new-insights-in-bone-metabolism-in-elderly-female-with-osteoporosis-the-role-of-leptin/

  14. Upadhyay J, Farr OM, Mantzoros CS. The role leptin in regulation bone metabolism. Metabolism. 2015; 64 (1): 105-113. DOI: 10.1016/j.metabol.2014.10.021

  15. Bandaru P, Shankar A. Association Between Plasma Leptin Levels and Diabetes Mellitus. Metab Syndr Relat Disord. 2011; 9 (1): 19-23. DOI: 10.1089/ met.2010.0037

  16. Fischer S, Hanefeld M, Ha ner S, et al. Insulin-resistant patients with type 2 diabetes mellitus have higher serum leptin levels independently of body fat mass. Acta Diabetol. 2002; 39 (3): 105-110. DOI: 10.1007/ s005920200027

  17. Malecha-Jedraszek A, Burska A, Matyjaszek-Matuszek B, Donica H. Serum leptin concentration in patients with type 2 diabetes. Current Issues in Pharmacy and Medical Sciences. 2015; 28 (4): 236-240. DOI: 10.1515/cipms-2015-0078

 

UDC 616.233-002

DOI: 10.20969/VSKM.2023.16(2).64-71

PDF download THE ROLE OF SUBJECTIVE AND OBJECTIVE CRITERIA IN THE ASSESSMENT OF THE STATE OF PATIENTS WITH BRONCHOBSTRUCTIVE DISEASES IN REMOTE MONITORING CONDITIONS

SHUBINA KSENIIA M., ORCID: 0009-0001-2444-8251, Internal medicine doctor of scienti c and clinical centre No 2, Russian research center of surgery named after academician B.V. Petrovsky, Moscow, Russia, 117593, Lithuanian Boulevard, 1A, phone: 89162557548, e-mail: ksu664@gmail.com

MISHLANOV VITALIY J., ORCID: 0000-0002-8428-6020, D. Med. Sci., Professor, Corresponding Member of RAS, Secretary of the Electronic and Mobile Medicine Group of the European Respiratory Society, the Head of Department of introduction into internal medicine No 1, E.A. Vagner Perm State Medical University, Russia, 614990, Perm, Petropavlovskaya str. 26, phone: 89504677696, e-mail: permmed@hotmail.com

NIKITIN IGOR G., ORCID: 0000-0003-1699-0881, D. Med. Sci., Professor, the Head of Department of Advanced Internal Medicine of Pirogov Russian National Research Medical University, Russia, 117593, Moscow, Lithuanian Boulevard, 1A, phone: 89161615727, e-mail: igor.nikitin.64@mail.ru

BEKKER KSENIIA N., ORCID: 0000-0002-3023-4305, C. Med. Sci., associate professor of the Department of introduction into internal medicine No 1 of E.A. Vagner Perm State Medical University, Russia, 614990, Perm, st. Petropavlovskaya, 26, phone: 89824694142, e-mail: ksenya51@mail.ru

EMELKINA VERONIKA V., ORCID: 0009-0003-0934-9196, Postgraduate student of the Department of introduction into internal medicine No 1 of E.A. Vagner Perm State Medical University, Russia, 614990, Perm, st. Petropavlovskaya, 26, phone: 89082497243, e-mail: emelkina.ya97@yandex.ru

SHUBIN IGOR V., ORCID: 0000-0003-2393-4685, D. Med. Sci., Honored Doctor of the Russian Federation, professor of Department of Advanced Internal Medicine of Pirogov Russian National Research Medical University, Russia, 105077, Moscow, 11th Parkova St., 32, bldg. 4, phone: 89055003530, e-mail: shubin-igor@mail.ru

Abstract. Introduction. Wearable or home electronic devices with the function of transmitting information at a distance are used for the purpose of remote dynamic monitoring of the condition of patients. Aim. To determine the e ectiveness of the use of "new" criteria for assessing the health status of patients with broncho-obstructive diseases in order to monitor remotely. Material and methods. 28 patients with broncho-obstructive diseases who were admitted for inpatient treatment were examined. Most of them had comorbidities, mainly cardiovascular pathology. A general clinical examination and special research methods were performed: an interactive survey using the respiratory module of the Electronic Polyclinic program, remote monitoring of vital signs using a smart watch and a mobile application for recording and transmitting information, a 6-minute walk test with simultaneous recording of vital signs with using a smart watch, a questionnaire and a scale for assessing the usability of the System usability scale system. The analysis of the results was performed by using the Statistica 13.0 software package. Results and discussion. Interactive survey corresponded to the severity of dyspnea according to the mMRC and Borg scales. The 6-minute walk test showed a signi cant limitation of physical activity and an increase in heart rate. The deep sleep phase has been limited. The CRP index averaged 7.78±8.48 μg/l. More than 85% of patients expressed their willingness to continue observation. The results of the correlation analysis demonstrated a direct relationship with the patient's physical activity assessment and the results of the 6-minute walk test, and an inverse relationship with the 6-minute walk test result and the patients' age, severity of respiratory failure and CRP concentration. The duration of deep sleep is inversely correlated with the SpO2 value. Our studies made it possible to compare the obtained data with the results of traditional methods of examining a patient, to con rm the position that the physical activity of a patient with broncho-obstructive disease is connected with indicators of the function of external respiration, and also that the total duration of sleep of COPD patients mainly consists of light sleep with a decrease in the duration of deep sleep. An inverse relationship was found with the duration of deep sleep and the concentration of CRP and the value of SpO2. The described monitoring system allows you to timely adjust the treatment regimen, reduce the number of hospitalizations, the risk of exacerbation or death.Conclusion. Additional instrumental control of vital parameters increases the e ciency of the system of long-term remote monitoring of patients with broncho-obstructive diseases. the indicators represent the severity of the symptoms of the disease and the degree of violations of the indicators of the function of external respiration.

Keywords: broncho-obstructive diseases, remote monitoring, interactive survey, smart watch, shortness of breath, sleep quality, CRP.

For reference: Shubina KM, Mishlanov VJ, Nikitin IG, et al. The role of subjective and objective criteria in the assessment of the state of patients with bronchoobstructive diseases in remote monitoring conditions. The Bulletin of Contemporary Clinical Medicine. 2023; 16(2): 64-71. DOI: 10.20969/VSKM.2023.16(2).64-71.

References

1. Чучалин А.Г., Черешнев В.А., Мишланов В.Ю., и др. Биоэтика, искусственный интеллект и медицинская диагностика. Пермь: ПГМУ, 2019. - 208с. [Chuchalin AG, Chereshnev VA, Mishlanov VYu, et al. Bioetika, iskusstvennyj intellekt i medicinskaya diagnostika [Bioethics, artificial intelligence and medical diagnostics]. Perm': PGMU [Perm: PGMU]. 2019; 208 p. (In Russ.)].

2. Chuchalin AG, Chereshnev VA, Mishlanov VJu, Mishlanov YaV, Nikitin AE, Shubin IV Bioethics, artificial intelligence and medical diagnosis / Trans. by V. Alekseev. Perm: E.A. Vagner PSMU. 2019; 184 p.

3. Шубин И.В., Мишланов В.Ю., Кошурникова Е.П. Клинический электронный регистр больных хронической обструктивной болезнью легких: анализ эффективности медикаментозной терапии и вакцинопрофилактики больных хронической обструктивной болезнью легких, их влияние на летальность // Практическая пульмонология. – 2020. – № 3. – С. 40-48. [Shubin IV, Mishlanov VYu, Koshurnikova EP. Klinicheskij elektronnyj registr bol'nyh hronicheskoj obstruktivnoj bolezn'yu legkih: analiz effektivnosti medikamentoznoj terapii i vakcinoprofilaktiki bol'nyh hronicheskoj obstruktivnoj bolezn'yu legkih, ih vliyanie na letal'nost' [Clinical electronic register of patients with chronic obstructive pulmonary disease: analysis of the effectiveness of drug therapy and vaccination of patients with chronic obstructive pulmonary disease, their impact on mortality]. Prakticheskaya pul'monologiya [Practical pulmonology]. 2020; 1: 40-48 (In Russ.)].

4. Шубин И.В., Мишланов В.Ю., Кошурникова Е.П. Клинический электронный регистр больных хронической обструктивной болезнью легких: анализ факторов, ассоциированных с летальностью // Вестник современной клинической медицины. – 2021. – Т. 14, № 1. – С. 62-68. [Shubin IV, Mishlanov VYu, Koshurnikova EP. Klinicheskij elektronnyj registr bol'nyh hronicheskoj obstruktivnoj bolezn'yu legkih: analiz faktorov, associirovannyh s letal'nost'yu [Clinical electronic register of patients with chronic obstructive pulmonary disease: analysis of factors associated with mortality]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Contemporary Clinical Medicine]. 2021; 14 (1): 62-68 (In Russ.)]. DOI: 10.20969/VSKM.2021.14(1).62-68

5. Шубин И.В., Мишланов В.Ю., Кошурникова Е.П. Применение методики структурированного интерактивного опроса в динамическом наблюдении и дифференциальной диагностике бронхообструктивных заболеваний и внебольничной пневмонии // Вестник Центрального научно-исследовательского института туберкулеза, 2020. – № 4. – С. 64-72. [Shubin IV, Mishlanov VYu, Koshurnikova EP. Primenenie metodiki strukturirovannogo interaktivnogo oprosa v dinamicheskom nablyudeniii differencial'noj diagnostike bronhoobstruktivnyh zabolevanij i vnebol'nichnoj pnevmonii [Application of structured interactive survey methodology in dynamic observation and differential diagnosis of bronchoobstructive diseases and communityacquired pneumonia]. Vestnik Central'nogo nauchnoissledovatel'skogo instituta tuberkuleza [Bulletin of the Central Research Institute of Tuberculosis]. 2020; 1: 64-72 (In Russ.)]. DOI: 10.7868/S258766782004007X

6. Мишланов В.Ю., Шубин И.В., Рощин Д.О., Плутницкий А.Н. Вопросы оказания медицинской помощи больным пульмонологического профиля: до и после эпидемии Covid-19 в Российской Федерации // Вестник Росздравнадзора. – 2020. – № 4. – С. 76-81. [Mishlanov VYu, Shubin IV, Roshchin DO, Plutnickij AN. Voprosy okazaniya medicinskoj pomoshchi bol'nym pul'monologicheskogo profilya: do i posle epidemii Covid-19 v Rossijskoj Federacii [Issues of providing medical care to patients with a pulmonological profile: before and after the Covid-19 epidemic in the Russian Federation] Vestnik Roszdravnadzora [Bulletin of Roszdravnadzor]. 2020; 4: 76-81 (In Russ.)]. DOI: 10.35576/2070-7940-2020-4-76-81

7. Приказ Министерства здравоохранения Российской Федерации от 15.03.2022 года № 168н «Об утверждении Порядка проведения диспансерного наблюдения за взрослыми». [Prikaz Ministerstva zdravoohraneniya Rossijskoj Federacii ot 15.03.2022 goda № 168n «Ob utverzhdenii Poryadka provedeniya dispansernogo nablyudeniya za vzroslymi» [Order of the Ministry of Health of the Russian Federation No. 168n dated 03/15/2022 "On approval of the Procedure for conducting dispensary supervision of adults"(In Russ.)]. http://publication.pravo.gov.ru/Document/View/0001202204210027. Доступно 29.03.2023

8. Мишланов В.Ю., Шубин И.В., Беккер К.Н., и др.Анализ электронного клинического регистра больных хронической обструктивной болезнью легких: эффективность динамического наблюдения и различных программ лечения // Терапевтический архив. – 2019. – Т. 91. – №1. – C. 78-83. [Mishlanov VYu, Shubin IV, Bekker KN, et al. Analiz elektronnogo klinicheskogo registra bol'nyh hronicheskoj obstruktivnoj bolezn'yu legkih: effektivnost' dinamicheskogo nablyudeniya i razlichnyh programm lecheniya [Analysis of the electronic clinical register of patients with chronic obstructive pulmonary disease: the effectiveness of dynamic monitoring and various treatment programs]. Terapevticheskij arhiv [Therapeutic Archive]. 2019; 91 (1): 78-83 (In Russ.)]. DOI: 10.26442/00403660.2019.01.000034

9. Brooke J. SUS: a quick and dirty usability scale. Usability Eval. Ind. 1995. 189.

10. Deldar K, Bahaadinbeigy K, Tara SM. Teleconsultation and Clinical Decision Making: a Systematic Review. Acta Inform Med. 2016 Jul 16; 24(4): 286-292.

11. Bernocchi P, Giordano A, Pintavalle G, Galli T, Ballini Spoglia E, Baratti D, Scalvini S. Feasibility and Clinical Efficacy of a Multidisciplinary Home-Telehealth Program to Prevent Falls in Older Adults: A Randomized Controlled Trial. J Am Med Dir Assoc. 2019 Mar; 20(3)340-346.

12. Shanbehzadeh M, Kazemi-Arpanahi H, Kalkhajeh SG, Basati G. Systematic review on telemedicine platforms in lockdown periods: Lessons learned from the COVID-19 pandemic. J Educ Health Promot. 2021 Jun 30; 10:211.

13. McKinstry B, Alexander H, Maxwell G, Blaikie L, Patel S, Guthrie B; Technology Enabled Care TeleCOVID Group. The Use of Telemonitoring in Managing the COVID-19 Pandemic: Pilot Implementation Study. JMIR Form Res. 2021 Sep 27;5(9):e20131

14. Martin SB, Morrow JR Jr, Jackson AW, Dunn AL. Variables related to meeting the CDC/ACSM physical activity guidelines. Med Sci Sports Exerc. 2000; 32(12):2087–92.

15. Albarrati AM, Gale NS, Munnery MM, Cockcroft JR, Shale DJ. Daily physical activity and related risk factors in COPD. BMC Pulm Med. 2020 Mar 5; 20(1):60.

16. Plaisance EP, Grandjean PW. Physical activity and high-sensitivity C-reactive protein. Sports Med. 2006; 36(5):443-58. DOI: 10.2165/00007256-200636050-00006. PMID: 16646631

17. Pokrzywinski RF, Meads DM, McKenna SP, Glendenning GA, Revicki DA. Development and psychometric assessment of the COPD and Asthma Sleep Impact Scale (CASIS). Health Qual Life Outcomes. 2009 Dec 7; 7: 98.

18. Azkona M.S., Nuñez A., Esquinas C., Barrecheguren M., Loeb E., Izquierdo J.L., De Lucas P., Perez M., Miravitlles M. Assessing the impact of COPD on sleep quality with the CASIS questionnaire European Respiratory Journal Sep 2019, 54 (suppl 63) OA3290.

19. Serin EK, Ister ED, Ozdemir A. The relationship between sleep quality and dyspnoea severity in patients with COPD. Afr Health Sci. 2020 Dec; 20(4):1785-1792.

20. Мишланов В.Ю., Чучалин А.Г., Черешнев В.А., др. Новые технологии в реабилитации больных респираторными заболеваниями. Телемониторинг и телереабилитация // Практическая пульмонология. – 2019. – № 3. – С. 28-31. [Mishlanov VYu, Chuchalin AG, Chereshnev VA, et al. Novye tekhnologii v reabilitacii bol'nyh respiratornymi zabolevaniyami. Telemonitoring i telereabilitaciya [New technologies in the rehabilitation of patients with respiratory diseases. Telemonitoring and telereabilitation]. Prakticheskaya pul'monologiya [Practical pulmonology]. 2019; 3: 28-31 (In Russ.)].

21. Шубин И.В., Мишланов В.Ю., Кошурникова Е.П. Клинический электронный регистр больных хронической обструктивной болезнью легких: анализ эффективности медикаментозной терапии и вакцинопрофилактики больных хронической обструктивной болезнью легких, их влияние на летальность // Практическая пульмонология. – 2021. – № 3. – С. 40-48. [Shubin IV, Mishlanov VYu, Koshurnikova EP. Klinicheskij elektronnyj registr bol'nyh hronicheskoj obstruktivnoj bolezn'yu legkih: analiz effektivnosti medikamentoznoj terapii i vakcinoprofilaktiki bol'nyh hronicheskoj obstruktivnoj bolezn'yu legkih, ih vliyanie na letal'nost' [Clinical electronic register of patients with chronic obstructive pulmonary disease: analysis of the effectiveness of drug therapy and vaccination of patients with chronic obstructive pulmonary disease, their impact on mortality]. Prakticheskaya pul'monologiya [Practical pulmonology]. 2021; 3: 40-48 (In Russ.)].

22. Шубин И.В. Диагностический и лечебный алгоритмы у больных с хроническими обструктивными заболеваниями органов дыхания и пневмонией. Автореф. дисс. … докт. мед. наук. СПб. – 2022. – 47 с. [Shubin IV. Diagnosticheskij i lechebnyj algoritmy u bol'nyh s hronicheskimi obstruktivnymi zabolevaniyami organov dyhaniya i pnevmoniej. Avtoreferat dissertacii doktora medicinskih nauk [Diagnostic and therapeutic algorithms in patients with chronic obstructive respiratory diseases and pneumonia. Abstract of the dissertation of a doctor of medical sciences]. Sankt-Peterburg [Saint-Petersburg]. 2022, 47p. (In Russ.)].

23. Каткова А.В., Шубин И.В., Мишланов В.Ю., и др. Интерактивный опрос с помощью автоматизированной системы «Электронная поликлиника» при консультировании в удалённом доступе // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и технические науки. – 2019. – № 9. – С. 125-131. [KatkovaAV, Shubin IV, Mishlanov VYu, aet al. Interaktivnyj opros s pomoshch'yu avtomatizirovannoj sistemy «Elektronnaya poliklinika» pri konsul'tirovanii v udalyonnom dostupe [Interactive survey using the automated system "Electronic polyclinic" for consulting in remote access]. Sovremennaya nauka: aktual'nye problemy teorii i praktiki. Seriya: Estestvennye i tekhnicheskie nauki [Modern science: actual problems of theory and practice. Series: Natural and Technical Sciences]. 2019; 9: 125-131 (In Russ.)].

24. Мишланов В.Ю., Чучалин А.Г., Черешнев В.А., и др. Новые технологии в медицине. Телемониторинг и телереабилитация // Современный мир, актуальные вопросы биоэтики, молекулярной и персонализированной медицины: сборник материалов международного Евро-Азиатского конгресса по вопросам биоэтики, молекулярной и персонализированной медицины «Biomed-inn-2019» / под ред. проф. И.П. Корюкиной, проф. Ю.В. Каракуловой, проф. В.Ю. Мишланова, проф. Е.Г. Фурмана. – Пермь: Изд-во Перм. нац. исслед. политехн. ун-та, 2019. – С. 117-125. [Mishlanov VYu, Chuchalin AG, Chereshnev VA, et al. Novye tekhnologii v medicine. Telemonitoring i telereabilitaciya [New technologies in medicine. Telemonitoring and telereabilitation]. Sovremennyj mir, aktual'nye voprosy bioetiki, molekulyarnoj i personalizirovannoj mediciny: sbornik materialov mezhdunarodnogo Evro-Aziatskogo kongressa po voprosam bioetiki, molekulyarnoj i personalizirovannoj mediciny «Biomed-inn-2019» [The modern world, topical issues of bioethics, molecular and personalized medicine: proceedings of the International Euro-Asian Congress on Bioethics, Molecular and Personalized Medicine "Biomedinn-2019"]. 2019; 117-125 (In Russ.)].

25. Шубин И.В., Мишланов В.Ю. Основные элементы электронной информационной системы здравоохранения в Российской Федерации (обзор и анализ научных публикаций) // Вестник современной клинической медицины. – 2020. – Т. 13, вып. 3. – С. 74–80. [Shubin IV, Mishlanov VYu. Osnovnye elementy elektronnoj informacionnoj sistemy zdravoohraneniya v Rossijskoj Federacii (obzor i analiz nauchnyh publikacij) [The main elements of the electronic health information system in the Russian Federation (review and analysis of scientific publications)]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Contemporary Clinical Medicine]. 2020; 13 (3): 74–80 (In Russ.)]. DOI: 10.20969/VSKM.2020.13(3).74-80

  

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UDC: 616-072.85

DOI: 10.20969/VSKM.2023.16(2).72-79

PDF download HISTORY AND REALITY OF APPLICATION THE 6 MINUTE WALK TEST IN CHILDREN

BUSHUEVA ELVIRA V., ORCID ID: 0000-0001-7026-3250; Doctor of Medical Sciences, Professor of the Department of Pediatrics and Pediatric Surgery, Faculty of Medicine, Chuvash State University named after I.N. Ulyanov, Address: 428017 Chuvash Republic, Cheboksary, Moskovsky Ave., 45, е-mail: evbush@mail.ru

DIANOVA TATYANA I., ORCID ID: 0000-0001-6622-9906; Senior Lecturer of the Department of Pediatrics and Pediatric Surgery, Faculty of Medicine, Chuvash State University named after I.N. Ulyanov, 428017, Chuvash Republic, Cheboksary, Moskovsky Ave., 45, е-mail: D.t.i_21@mail.ru

IVANOVA OLGA N., ORCID ID: 0000-0002-6059-9890; Senior Lecturer of the Department of Pediatrics and Pediatric Surgery, Faculty of Medicine, Chuvash State University named after I.N. Ulyanov, 428017, Chuvash Republic, Cheboksary, Moskovsky Ave., 45, е-mail: lonleb@mail.ru

GERASIMOVA LYUDMILA I., ORCID ID: 0000-0002-3976-0934; MD, Dr. Med. Sci, prof., Professor of the Department of Obstetrics and Gynecology of the Medical Institute of Continuing Education of the Federal State Budgetary Educational Institution of Higher Education «Russian Biotechnological University» (FSBEU HE «ROSBIOTEKH»),125080, Moscow, Volokolamsk highway, 11, e-mail: profgera@mail.ru

PETROV ANDREY G., ORCID ID: 0000-0001-6622-9906; Associate Professor of the Department of Pediatrics and Pediatric Surgery, Faculty of Medicine, Chuvash State University named after I.N. Ulyanov, 428017, Chuvash Republic, Cheboksary, Moskovsky Ave., 45, e-mail: dr.petrov-a.g@yandex.ru

SITDIKOVA IRINA D., ORCID ID: 0000-0002-6835-402X, Dr. Med. Sci., Professor of the Department of Biomedical Engineering and Innovation Management, Kazan (Volga region) Federal University, 420008, Kazan, Russian Federation, 18 Kremlevskaya St, е-mail: sar1002@mail.ru

Abstract. Introduction. The application of the 6-minute walk test to assess the functional status of a patient is a safe, simple and easily accessible method in assessing the patient’s functional abilities, the e ectiveness of treatment and rehabilitation and the prognosis of various diseases. Aim. TTo analyze the scienti c medical literature containing the application of the 6-minute walk test in assessing the functional status of children and adolescents. Material and methods. The test was rst described in 1963 in adult patients with diseases of the bronchopulmonary system, with subsequent improvements the test was used in patients with heart disease and became a simple objective indicator of functional physical performance. After the adoption of the standards for the 6-minute walk test by the American Thoracic Society jointly with the European Respiratory Society (2002), widespread application began not only in patients, but also in healthy adults. For the rst time, the 6-minute walk test among healthy children was conducted in 2005 in China, later control test values, percentile curves, reference equations and formulas were presented by Austria, Great Britain, the USA, etc. Scientists con rmed the safety and simplicity of the 6-minute walk test, proved a high correlation of the test with gender, height, age, weight, body mass index, pulse and blood pressure, arm span, etc. They proved that the ethnicity and geographical di erences of the subjects are very important indicators that a ect the test results. In the Russian Federation, the implementation of the 6-minute walk test is limited to sick children and regulatory values, and we have not found reference formulas. Conclusion. The reference values obtained for the 6-minute walk test in healthy children in one country should not be used for children in other countries, since the analysis showed a signi cant di erence in the control values of the distance traveled.

Key words: 6-minute walk test, children, adolescents, functional state.

For reference: Bushueva EV, Dianova TI, Ivanova ON, et al. History and reality of application the 6 minute walk test in children. The Bulletin of Contemporary Clinical Medicine. 2023; 16(2): 72-79. DOI: 10.20969/VSKM.2023.16(2).72-79.

References

  1. ATS Committee on Pro ciency Standards for Clinical Pulmonary Function Laboratories. ATS statement: guidelines for the sixminute walk test. Am J Respir Crit Care Med. 2002; 166 (1): 111-7. DOI: 10.1164/ ajrccm.166.1.at1102

  2. Чикина С.А., Атаман К.С. Внелабораторные нагрузочные тесты // Астма и аллергия. – 2018. – No4. – С.17-21. [Chikina SA, Ataman KS. Vnelaboratornye nagruzochnye testy [Extralaboratory stress tests]. Astma i allergija [Asthma and Allergies]. 2018; (4):17-21. (In Russ.)].

  3. Чикина С.А. Внелабораторные нагрузочные тесты при патологии органов дыхания // Креативная хирургия и онкология. – 2010. – No1. – C.82-95. [Chikina SA. Vnelaboratornye nagruzochnye testy pri patologii organov dykhaniya [Pulmonology loading tests out of laboratories to estimate the patient physical state]. Kreativnaja hirurgija i onkologija [Creative surgery and oncology]. 2010; (1): 82-95. (In Russ.)].

  4. Wasserman K; Hansen JE, Sue, et al. Principles of Exercise Testing and Interpretation. Journal of Cardiopulmonary Rehabilitation. 1987; 7 (4): 189.

  5. Weisman IM, Zeballos RJ. An integrated approach to the interpretation of cardiopulmonary exercise testing. Clin Chest Med. 1994; 15 (2): 421-45.

  6. Cahalin L, Pappagianopoulos P, Prevost S, et al. The relationship of the 6-min walk test to maximal oxygen consumption in transplant candidates with end-stage lung disease. Chest.1995; 108 (2): 452-459. DOI: 10.1378/chest.108.2.452

  7. Singh SJ, Morgan MD, Hardman AE, et al. Comparison of oxygen uptake during a conventional treadmill test and the shuttle walking test in chronic air ow limitation. Eur Respir J. 1994; 7 (11): 2016-2020.

  8. Morales FJ, Martínez A, Méndez M, et al. A shuttle walk test for assessment of functional capacity in chronic heart failure. Am Heart J. 1999; 138 (2 Pt 1): 291-298. DOI: 10.1016/s0002-8703(99)70114-6

  9. Guyatt GH, Townsend M, Keller J, et al. Measuring functional status in chronic lung disease: conclusions from a randomized control trial. Respir Med. 1991; 85 Suppl B: 17-21; discussion 33-37.

  10. Noseda A, Carpiaux JP, Prigogine T, Schmerber J. Lung function, maximum and submaximum exercise testing in COPD patients: reproducibility over a long interval. Lung. 1989; 167(4): 247-257. DOI: 10.1007/BF02714953

11. Чечельницкая С.М, Румянцев А.Г., Касаткин В.Н. и др. Особенности физического статуса детей 4–18 лет, лечившихся от гемобластозов и опухолей ЦНС // Педиатрия. Журнал им. Г.Н. Сперанского. – 2019. – Т. 98. – No 2. – С.227-234. [Chechelnitskaya SM, Rumyantsev AG, Kasatkin VN, et al. Osobennosti zicheskogo statusa detei 4–18 let, lechivshikhsya ot gemoblastozov i opukholei TsNS [Peculiarities of the physical status of children aged 4-18 treated for hemoblastosis and CNS tumors]. Pediatriya. Zhurnal im. G.N. Speranskogo [Journal “Pediatria” named after G.N. Speransky]. 2019; 98 (2): 227-234. (In Russ.)].

12. Бубнова М.Г., Персиянова-Дуброва А.Л. Применение теста с шестиминутной ходьбой в кардиореабилитации // Кардиоваскулярная терапия и профилактика. 2020 – Т.19. – No4. – С.102-111. [Bubnova MG, Persiyanova-Dubrova AL. Primenenie testa s shestiminutnoi khod’boi v kardioreabilitatsii [Six-minute walk test in cardiac rehabilitation]. Kardiovaskulyarnaya terapiya i pro laktika [Cardiovascular Therapy and Prevention]. 2020; 19 (4): 102-111. (In Russ.)]. DOI:10.15829/1728-8800-2020-2561

13. Михайловская Т.В., Назарова О.А., Довгалюк Ю.В., и др. Методологические подходы к оценке результатов теста с шестиминутной ходьбой у больных ишемической болезнью сердца // Вестник восстановительной медицины. – 2021. – Т. 20. – No3. – С.37-44. [Mikhailovskaya TV, Nazarova OA, Dovgalyuk YV, et al. Metodologicheskie podkhody k otsenke rezul’tatov testa s shestiminutnoi khod’boi u bol’nykh ishemicheskoi bolezn’yu serdtsa [Methodological issues of assessment of six-minute walk test in patients with coronary artery disease]. Vestnik vosstanovitel’noi meditsiny [Bulletin of Rehabilitation Medicine]. 2021; 20 (3):37-44. (In Russ.)]. DOI: 10.38025/2078-1962-2021-20-3-37-44

14. Чечельницкая С.М., Баербах А.В., Сарайкин Ю.В., и др. Применение теста 6-минутной ходьбы для оценки физической выносливости детей и подростков, лечившихся от онкологических заболеваний // Современные проблемы науки и образования. – 2018. – No6. [Chechelnitskaya SM, Baerbakh AV, Saraykin YV, et al. rimenenie testa 6-minutnoi khod’by dlya otsenki zicheskoi vynoslivosti detei i podrostkov, lechivshikhsya ot onkologicheskikh zabolevanii [Application of the test of 6-minute walking for estimation of the physical endurance of children and adolescents treated for oncological diseases]. Sovremennye problemy nauki i obrazovaniya [Modern Problems of Science and Education. Surgery]. 2018; (6). (In Russ.)]. URL: https://science-education.ru/ru/ article/view?id=28343 (дата обращения: 24.10.2022).

15. Чикина С.Ю. Роль теста с 6-минутной ходьбой в ведении больных с бронхолегочными заболеваниями // Практическая пульмонология. – 2015. – No 4. – С.34-38. [Chikina SA. Rol’ testa s 6-minutnoi khod’boi v vedenii bol’nykh s bronkholegochnymi zabolevaniyami [The role of the 6-minute walk test in the management of patients with bronchopulmonary  diseases]. Prakticheskaya pul’monologiya [Practical Pulmonology]. 2015; (4): 34-38. (In Russ.)].

  1. Михайловская Т.В., Мишина И.Е., Назарова О.А., и др. Способы оценки толерантности к физической нагрузке по результатам теста с шестиминутной ходьбой в ходе реабилитации пациентов с ишемической болезнью сердца // Физическая и реабилитационная медицина, медицинская реабилитация. – 2021. – T.3. – No1. – C.4-10. [Mikhailovskaya TV, Mishina IE, Nazarova OA, et al. Sposoby otsenki tolerantnosti k zicheskoi nagruzke po rezul’tatam testa s shestiminutnoi khod’boi v khode reabilitatsii patsientov s ishemicheskoi bolezn’yu serdtsa [Methods of evaluation of tolerance yo physical activity based on six-minute walking test during outpatient rehabilitation of patients with ischemic heart disease]. Fizicheskaya i reabilitatsionnaya meditsina, meditsinskaya reabilitatsiya [Physical and rehabilitation medicine, medical rehabilitation] 2021; 3(1): 4–10. (In Russ.)]. DOI: 10.36425/rehab64360

  2. Будневский А.В., Кравченко А.Я., Токмачев Р.Е., и др. Диагностические, прогностические и терапевтические возможности использования теста 6-минутной ходьбы у пациентов с хронической сердечной недостаточностью // Кардиоваскулярная терапия и профилактика. – 2020. – T. 19. – No6. – C.106-116. [Budnevsky AV, Kravchenko AYa, Tokmachev RE, et al. Diagnosticheskie, prognosticheskie i terapevticheskie vozmozhnosti ispol’zovaniya testa 6-minutnoi khod’by u patsientov s khronicheskoi serdechnoi nedostatochnost’yu [Diagnostic, prognostic and therapeutic potential of 6-minute walk test in patients with heart failure]. Kardiovaskulyarnaya terapiya [Cardiovascular Therapy and Prevention]. 2020; 19(6): 106-116. (In Russ.)]. DOI:10.15829/1728-8800-2020-2460

  3. Balke B. A simple eld test for the assessment of physical tness. Civil Aeromedical Research Institute US. 1963; (53): 1-8.

  4. Cooper KH. Correlation between eld and treadmill testing. JAMA. 1968; 203: 201-204.

  5. Butland RJ, Pang J, Gross ER, et al. Two-, Six-, and 12-Minute Walking Tests in Respiratory Disease. Br Med J (Clin Res Ed). 1982; 284 (6329): 1607-8. DOI: 10.1136/bmj.284.6329.1607

  6. Guyatt GH, Sullivan MJ, Thompson PJ, et al. The 6-minute walk: a new measure of exercise capacity in patients with chronic heart failure. Can Med Assoc J. 1985; 132 (8): 919-923.

  7. Lipkin DP, Scriven AJ, Crake T, Poole-Wilson PA. Six-minute walking test for assessing exercise capacity in chronic heart failure. Br Med J (Clin Res Ed). 1986; 292: 653-655. DOI: 10.1136/bmj.292.6521.653

  8. Langenfeld H, Schneider B, Grimm W, et al. The six-minute walk-an adequate exercise test for pacemaker patients? Pacing Clin Electrophysiol. 1990; 13(12Pt2): 1761-1765. DOI: 10.1111/j.1540-8159.1990.tb06886.x

  9. Bernstein ML, Despars JA, Singh NP, et al. Reanalysis of the 12-minute walk in patients with chronic obstructive pulmonary disease. Chest. 1994; 105 (1): 163–167.

25. Leach RM, Davidson AC, Chinn S, et al. Portable liquid oxygen and exercise ability in severe respiratory disability. Thorax. 1992; 47: 781–789.

26. Enright PL, Sherrill DL. Reference equations for the six-minute walk in healthy adults. Am J Respir Crit Care Med. 1998; 158 (5 Pt 1): 1384-1387. DOI: 10.1164 / ajrccm.158.5.9710086.

27. Nixon PA, Joswiak ML, Fricker FJ. A six-minute walk test for assessing exercise tolerance in severely ill children. J Pediatr. 1996; 129: 362–366.

28. Gulmans VA, Veldhoven N, Meer K, Helders P. The six-minute walking test in children with cystic brosis: reliability and validity Pediatr Pulmonol. 1996; 22(2): 85-89. DOI: 10.1002/(SICI)1099-0496(199608)22:2<85:AID-PPUL1>3.0.CO;2-I

29. Upton CJ, Tyrrell JC, Hiller EJ. Two-minute walking distance in cystic brosis Arch Dis Child. 1988; 63 (12): 1444-1448. DOI: 10.1136/adc.63.12.1444

30. Li AM, Yin J, Yu CCW, Tsang T, et al. The six-minute walk test in healthy children: reliability and validity. Eur Respir J. 2005; 25 (6): 1057-1060. DOI: 10.1183/09031936.05.00134904

31. Geiger R, Strasak A, Treml B, et al. Six-minute walk test in children and adolescents. J Pediatr. 2007; 150 (4): 395-9, 399.e1-2. DOI: 10.1016/j.jpeds.2006.12.052

32. Lammers AE, Hislop AA, Flynn Y, Haworth SG. The 6-minute walk test: normal values for children of 4-11 years of age. Arch Dis Child. 2008; 93 (6): 464-468. DOI: 10.1136/adc.2007.123653

33. Priesnitz CV, Rodrigues GH, Stumpf CS, Viapiana G, et al. Reference values for the 6-min walk test in healthy children aged 6-12 years. Pediatr Pulmonol. 2009; 44 (12) :1174-1179. DOI: 10.1002/ppul.21062

34. Saad HB, Prefaut C, Missaoui R, et al. Reference equation for 6-min walk distance in healthy North African children 6-16 years old. Pediatr Pulmonol. 2009; 44 (4): 316-324. DOI: 10.1002/ppul.20942

35. D’silva C, Vaishali K, Venkatesan P. Six-minute walk test-normal values of school children aged 7-12 y in India: a cross-sectional study. Indian J Pediatr. 2012; 79 (5): 597-601. DOI: 10.1007/s12098-011-0559-x

36. Klepper SE, Muir N. Reference values on the 6-minute walk test for children living in the United States. Pediatr Phys Ther. 2011; 23 (1): 32-40. DOI: 10.1097/ PEP.0b013e3182095e44

37. Gatica D, Puppo H, Villarroel G, et al. Reference values for the 6-minutes walking test in healthy Chilean children. Rev Med Chil. 2012; 140 (8): 1014-21. DOI: 10.4067/S0034-98872012000800007

38. Foeldvari I, Himmelmann GW. Preliminary results for 6-minute walk values in healthy German children. Pediatric Rheumatology. 2011; 9 (Suppl 1): P74. DOI:10.1186/1546-0096-9-S1-P74

39. Ulrich S, Hildenbrand FF, Treder U, et al. Reference values for the 6-minute walk test in healthy children and adolescents in Switzerland. BMC Pulm Med. 2013; 13: 49. DOI: 10.1186/1471-2466-13-49

40. Kanburoglu MK, Fevzi Murat Ozdemir FM, Secil Ozkan S, Tunaoglu FS. Reference values of the 6-minute walk test in healthy Turkish children and adolescents between 11 and 18 years of age. Respir Care. 2014; 59 (9): 1369-1375. DOI: 10.4187/respcare.02891

  1. Kahraman BÖ, Yüksel E, Nalbant A, et al. Reference values and prediction equation for the 6-minute walk test in healthy children aged 6–12 years old. Turk J Med Sci. 2019; 49 (4): 1126-1131. DOI: 10.3906/sag-1901-232

  2. Kahraman BÖ, Yüksel E, Nalbant A, et al. Arm span as a predictor of the six-minute walk test in healthy children. Braz J Phys Ther. 2021; 25 (3): 281-285. DOI: 10.1016/j.bjpt.2020.07.003.

  3. Chen CA, Chang CH, Lin MT, et al. Six-Minute Walking Test: Normal Reference Values for Taiwanese Children and Adolescents. Acta Cardiol Sin. 2015; 31 (3): 193-201. DOI: 10.6515/ acs20140721d

  4. de Assis Pereira Cacau L, Carvalho VO, Dos Santos Pin A, et al. TC6minBrasil Investigators; Authors of the TC6minBrasil study: Steering Committee: Reference Values for the 6-min Walk Distance in Healthy Children Age 7 to 12 Years in Brazil: Main Results of the TC6minBrasil Multi-Center Study. Respir Care. 2018; 63 (3): 339-346. DOI: 10.4187/respcare.05686

  5. Vandoni M, Correale L, Puci MV, et al. Six-minute walk distance and reference values in healthy Italian children: A cross-sectional study. PLoS One. 2018; 13 (10): e0205792. DOI: 10.1371/journal.pone.0205792

  6. Mylius CF, Paap D, Takken T. Reference value for the 6-minute walk test in children and adolescents: a systematic review Expert Rev Respir Med. 2016; 10 (12): 1335-1352. DOI: 10.1080/17476348.2016.1258305

  7. Rodríguez-Núñez I, Mondaca F, Casas B, et al. Normal values of 6-minute walk test in healthy children and adolescents: A systematic review and meta-analysis. Rev Chil Pediatr. 2018; 89 (1): 128-136. DOI: 10.4067/ S0370-41062018000100128

  8. Kasović M, Štefan L, Petrić V. Normative data for the 6-min walk test in 11–14 year-olds: a population-based study. BMC Pulm Med. 2021; 21(1): 297. DOI: 10.1186/s12890-021-01666-5

49. Guimarães ALA, Gomes Neto M, Carvalho VO. Can the use of reference values for the 6-min walk test from another country result in misinterpretation? Pediatr Pulmonol. 2022; 57 (11): 2866-2867. DOI: 10.1002/ppul.26106

50. Moalla W, Gauthier R, Maingourd Y, Ahmaidi S. Six-minute walking test to assess exercise tolerance and cardiorespiratory responses during training program in children with congenital heart disease. Int J Sports Med. 2005; 26 (9): 756-62. DOI: 10.1055/s-2004-830558. PMID: 16237621

51. Paap E, van der Net J, Helders P J M, Takken T. Physiologic response of the six-minute walk test in children with juvenile idiopathic arthritis. Arthritis Rheum. 2005; 53 (3): 351-356. DOI: 10.1002/art.21175

52. Cunha MT, Rozov T,de Oliveira RC, Jardim José R. Six-minute walk test in children and adolescents with cystic brosis. Pediatr Pulmonol. 2006; 41 (7): 618-22. DOI: 10.1002/ppul.20308

53. Morinder G, Mattsson E, Sollander C, et al. Six-minute walk test in obese children and adolescents: reproducibility and validity. Physiother Res Int. 2009; 14 (2): 91-104. DOI: 10.1002/pri.428

54. Elmahgoub SS, Van de Velde A, Peersman W, et al. Reproducibility, validity and predictors of six-minute walk test in overweight and obese adolescents with intellectual disability. Disabil Rehabil. 2012; 34(10): 846-51. DOI: 10.3109/09638288.2011.623757

55. Andrade LB, Silva DA, Salgado TL, et al. Comparison of six-minute walk test in children with moderate/severe asthma with reference values for healthy children. J Pediatr (Rio J). 2014; 90 (3): 250-257. DOI: 10.1016/j. jped.2013.08.006

 

UDC: 616.8-00; 616.8-092

DOI: 10.20969/VSKM.2023.16(2).80-88

PDF download AUTISM SPECTRUM DISORDER IN CHILDREN: DIAGNOSTIC SIGNIFICANCE OF ELECTROENCEPHALOGRAPHY

GAMIROVA RIMMA G., ORCID ID: 0000-0002-8582-592X; Scopus Author ID 25422029100, Researcher ID N-6910-2013, RSCI Author ID 641154, C. Med. Sci., Associate Professor, Head of Department of Neurology with courses in psychiatry, clinical psychology and medical genetics, Senior Researcher of Neurocognitive Research Laboratory of Kazan Federal University, Kazan, Russia, 420008, Kremlyovskaya Street, 18, email: r-gamirov@mail.ru

SAFINA AISILU R., ORCID IR: 0000-0001-9986-3217; Neurologist of the Neurology Department, Medical Unit of Kazan Federal University; Kazan, Russia, 420043, Chekhov street, 1А, email: aisilu.khakimova.1995@mail.ru

GOROBETS ELENA A., ORCID ID: 0000-0002-3859-5543; Scopus Author ID 56414621100 Researcher ID N-7983-2013, RSCI Author ID 728307, C. Philol. Sci., Associate Professor, Psychologist, Head of the Center for Speech Pathology, Head of the Department of Applied and Experimental Linguistics, Head of Neurocognitive Research Laboratory, Kazan Federal University, Kazan, Russia, 420008, Kremlyovskaya Street, 18, email: elena_gorobets@mail.ru

SAFINA DIANA R., ORCID ID: 0000-0002-6466-4979; Scopus Author ID 57224137067, Researcher ID AAS-1754-2020, RSCI Author ID 57224137067, C. Med. Sci., senior lecturer of Department of Neurology with courses in psychiatry, clinical psychology and medical genetics, Kazan Federal University, Kazan, Russia, 420008, Kremlyovskaya Street,, 18, email: safina_neuro@mail.ru

Abstract. Introduction. Early diagnosis of autism spectrum disorder in children is signi cant clinical problem due to the ever-increasing incidence of this condition in children. Aim. The aim of the study is a comprehensive analysis of data on the features of the bioelectrical activity of the brain in children with autism spectrum disorders, identi cation of the electroencephalography signi cance in the diagnosis of these disorders, including the ability to di erentiate their subtypes. Material and Methods. The materials for the review were scienti c articles indexed in Russian and international databases (Russian Science Citation Index, Scopus, Pubmed) for the period from 1995 to 2022. Results and discussion. The article presents systematized data related to the analysis of electroencephalograms in children with autism spectrum disorder which is carried out in di erent ways: visual and quantitative. The authors analyzed the changes in the electroencephalograms obtained using spectral analysis, identifying the functional connections of di erent areas of the brain, with the implementation of non-linear assessment methods. The theory of «mirror neurons» was discussed in connection with the peculiarities of the sensorimotor rhythm reactivity in children with autism spectrum disorder. Conclusion. The presence of electroencephalographic changes in children with autism spectrum disorders is con rmed, especially in the period from 3 to 12 months, although the degree of the sensitivity of methods for their detection at this stage is insu cient for accurate diagnosis. Dynamic electroencephalographic monitoring should be recommended for children with autistic disorders, especially if subclinical epileptiform activity is detected. It is also worth paying attention to the change in functional rhythms in dynamics. In general, results of electroencephalography are often more informative than neuroimaging methods, which in most cases do not reveal organic brain damage in the presence of obvious developmental disorder in a child. The most promising at present are non-linear methods of electroencephalograms analysis.

Key words: Autism spectrum disorders, electroencephalography, early diagnosis, neurophysiology, bioelectrical activity of the brain.

For reference: Gamirova RG, Sa na AR, Gorobets EA, Sa na DR. Autism spectrum disorder in children: diagnostic signi cance of electroencephalography. The Bulletin of Contemporary Clinical Medicine. 2023; 16(2): 80-88. DOI: 10.20969/VSKM.2023.16(2).80-88.

References

1. Rosello B, Berenguer C, Baixauli I, et al. Theory of Mind Profiles in Children With Autism Spectrum Disorder: Adaptive/Social Skills and Pragmatic Competence. Front Psychol. 2020; 11:567401. DOI: 10.3389/fpsyg.2020.567401

2. Мукаетова-Ладинска Е.Б., Симашкова Н.В., Мукаетова М.С. и др. Расстройства аутистического спектра у детей и взрослых: подходы к проблеме в разных странах // Журнал неврологии и психиатрии им. С.С. Корсакова. – 2018. – Т. 118, №12. - С. 92-99. [Mukaetova-Ladinska EB, Simashkova NV, Mukaetova MS, et al. Rasstroistva autisticheskogo spektra u detei i vzroslykh: podkhody k probleme v raznykh stranakh [Autism spectrum disorders in children and adults: the experience of reserches from different countries]. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova [S.S. Korsakov Journal of Neurology and Psychiatry]. 2018; 118 (12): 92-99. (In Russ.)]. DOI: 10.17116/jnevro201811812192

3. Zeidan J, Fombonne E, Scorah J, et al. Global prevalence of autism: a systematic review update. Autism Res. 2022; 1-13. DOI: 10.1002/aur.2696

4. Amaral DG, Li D, Libero L, et al. In pursuit of neurophenotypes: the consequences of having autism and a big brain. Autism Res. 2017; 10: 711–722. DOI: 10.1002/aur.1755

5. Sheldrick RC, Garfinkel D. Is a Positive DevelopmentalBehavioral Screening Score Sufficient to Justify Referral? A Review of Evidence and Theory. Acad Pediatr. 2017; 17: 464–470. DOI: 10.1016/j.acap.2017.01.016

6. Lord C, Risi S, Lambrecht L, et al. The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism. J Autism Dev Disord. 2000; 30 (3): 205–223. DOI: 10.1023/A:1005592401947

7. Gotham K, Pickles A, Lord C. Standardizing ADOS scores for a measure of severity in autism spectrum disorders. J Autism Dev Disord. 2009; 39: 693–705. DOI: 10.1007/s10803-008-0674-3

8. Reiersen AM. Early Identification of Autism Spectrum Disorder: Is Diagnosis by Age 3 a Reasonable Goal? Journal of the American Academy of Child and Adolescent Psychiatry. 2017; 56: 284–285. DOI: 10.1016/j.jaac.2017.02.003

9. Emerson RW, Adams Ch, Nishino T, et al. Functional neuroimaging of high-risk 6-month-old infants predicts a diagnosis of autism at 24 months of age. Sci Transl Med. 2017; 9 (393): 2882. DOI: 10.1126/scitranslmed. aag2882

10. Nowicka A, Cygan H, Tacikowski P. Name recognition in autism: EEG evidence of altered patterns of brain activity and connectivity. Mol. Autism. 2016; 7 (1): 38. DOI: 10.1186/s13229-016-0102-z

11. Sato JR, Vidal M, de Siqueira Santos S, et al. Complex Network Measures in Autism Spectrum Disorders. IEEE/ACM Trans Comput Biol Bioinform. 2018; 15 (2): 581-587. DOI: 10.1109/TCBB.2015.2476787

12. Chikhi S, Matton N, Blanchet S. EEG power spectral measures of cognitive workload: a meta-analysis. Psychophysiology. 2022; 59 (6): e14009. DOI: 10.1111/psyp.14009

13. Kaminska A, Eisermann M, Plouin P. Child EEG (and maturation). Handb Clin Neurol. 2019; 160: 125-142. DOI: 10.1016/B978-0-444-64032-1.00008-4

14. Wang J, Barstein J, Ethridge LE, et al. Resting state EEG abnormalities in autism spectrum disorders. J Neurodev Disord. 2013; 5 (1): 24. DOI: 10.1186/1866-1955-5-24

15. Arkilo D, Devinsky O, Mudigoudar B, et al. Electroencephalographic patterns during sleep in children with chromosome 15q11.2–13.1 duplications (Dup15q). Epilepsy Behav. 2016; 57(PtA): 133–6. DOI: 10.1016/j. yebeh.2016.02.010

16. Spence SJ, Schneider MT. The Role of Epilepsy and Epileptiform EEGs in Autism Spectrum Disorders. Pediatric Research. 2009; 65(6): 599–606. DOI: 10.1203/PDR.0b013e31819e7168

17. Yasuhara A. Correlation between EEG abnormalities and symptoms of autism spectrum disorder (ASD). Brain and Development. 2010; 32 (10): 791-798. DOI: 10.1016/j.braindev.2010.08.010

18. Gamirova R, Shaimardanova R, Ziganshina L. Pharmacoepidemiology of antiepileptic drugs in children: comparative analysis of e cacy and safety. International Journal of Risk and Safety in Medicine. 2012; 24 (3): 179-185. DOI: 10.3233/JRS-2012-0565

19. Viscidi EW, Triche EW, Pescosolido MF, et al. Clinical characteristics of children with autism spectrum disorder and co-occurring epilepsy. PLoS One. 2013; 8 (7): e67797. DOI: 10.1371/journal.pone.0067797

20. Tuchman R. Autism and epilepsy: what has regression got to do with it? Epilepsy Curr. 2006; 6: 107–11. DOI: 10.1111/j.1535-7511.2006.00113.x

21. Knickmeyer RC, Gouttard S, Kang C, et al. A structural MRI study of human brain development from birth to 2 years. J Neurosci. 2008; 28: 12176–82. DOI: 10.1523/ JNEUROSCI.3479-08.2008

22. Tuchman R, Cuccaro M, Alessandri M. Autizm and epilepsy: historical perspective. Brain and Development. 2010; 32 (9): 709-718. DOI: 10.1016/j. braindev.2010.04.008

23. Tuchman R, Rapin I. Regression in pervasive developmental disorders: seizures and epileptiform electroencephalogram correlates. Pediatrics. 1997; 99: 560-566. DOI: 10.1542/peds.99.4.560

24. Chez MG, Chang M, Krasne V, et al. Frequency of epileptiform EEG abnormalities in a sequential screening of autistic patients with no known clinical epilepsy from 1996 to 2005. Epilepsy Behav. 2006; 8: 267–71. DOI: 10.1016/j.yebeh.2005.11.001

25. Gabis L, Pomeroy J, Andriola MR. Autism and epilepsy: cause, consequence, comorbidity, or coincidence? Epilepsy Behav. 2005; 7 (4): 652–6. DOI: 10.1016 / j.yebeh.2005.08.008

26. Parmeggiani A, Barcia G, Posar A, et al. Epilepsy and EEG paroxysmal abnormalities in autism spectrum disorders. Brain Dev. 2010; 32 (9): 783–9. DOI: 10.1016/j.braindev.2010.07.003

27. Mantovani JF. Autistic regression and Landau-Kle ner syndrome: progress or confusion? Devel Med Child Neurol. 2000; 42: 349–53. DOI: 10.1017/ s0012162200210621

28. Lewine JD, Andrews R, Chez M, et al. Magnetoencephalographic patterns of epileptiform activity in children with regressive autism spectrum disorders. Pediatrics. 1999; 104 (3): 405–18. DOI: 10.1542/peds.104.3.405

29. Воронкова К.В., Пылаева О.А., Холин А.А. и др. Эпилепсия и аутизм. Данные собственного иссле-дования // Неврология, нейропсихиатрия, психосоматика. - 2013. - T. 5, No1S. - C.19–23. [Voronkova KV, Pylaeva OA, Kholin AA, et al. Epilepsiya i autizm. Dannyye sobstvennogo issledovaniya [Epilepsy and autism. Own results]. Nevrologiya, neiropsikhiatriya, psikhosomatika [Neurology, Neuropsychiatry, Psychosomatics]. 2013; 5 (S1): 19–23. (In Russ.)]. DOI: 10.14412/2074-2711-2013-2483

30. Capdevila OS, Dayyat E, Kheirandish-Gozal L, et al. Prevalence of epileptiform activity in healthy children during sleep. Sleep Med. 2008; 9 (3): 303-309. DOI: 10.1016/j.sleep.2007.03.024

31. Kim HL, Donnelly JH, Tournay AE, et al. Absence of seizures despite high prevalence of epileptiform EEG abnormalities in children with autism monitored in a tertiary care center. Epilepsia. 2006; 47 (2): 394–8. DOI: 10.1111/j.1528-1167.2006.00434.x

32. Мухин К.Ю. Когнитивная эпилептиформная дезинтеграция: дефиниция, диагностика, терапия // Русский журнал детской неврологии. - 2012. - Т. 7, No1. - С.3-20. [Mukhin KY. Kognitivnaya epileptiformnaya dezintegratsiya: de nitsiya, diagnostika, terapiya [Cognitive epileptiform disintegration: de nition, diagnosis, therapy]. Russkiy zhurnal detskoy nevrologii [Russian Journal of Child Neurology]. 2012; 7 (1): 3-20. (In Russ.)]. DOI: 10.17650/2073-8803-2012-7-1-3-20

33. Кузьмич Г.В., Синельникова А.Н., Мухин К.Ю. Дискуссионные вопросы коморбидности аутизма и эпилепсии: субклиническая эпилептиформная активность и аутистический эпилептиформный регресс // Русский журнал детской неврологии. – 2019. – Т. 14, No1. - С.40–48. [Kuzmich GV, Sinelnikova AN, Mukhin KY. Diskussionnyye voprosy komorbidnosti autizma i epilepsii: subklinicheskaya epileptiformnaya aktivnost i autisticheskiy epileptiformnyy regress [Controversial issues in comorbidity between epilepsy and autism: subclinical epileptiform activity and autistic epileptiform regression]. Russkiy zhurnal detskoy nevrologii [Russian Journal of Child Neurology]. 2019; 14 (1): 40-48. (In Russ.)]. DOI: 10.17650/2073-8803-2019-14-1-40-48

34. Boutros NN, Lajiness-O’Neill R, Zillgitt A, et al. EEG changes associated with autistic spectrum disorders. Neuropsychiatr Electrophysiol. 2015; 1 (1): 1–20. DOI:10.1186/S40810-014-0001-5

35. Perez Velazquez JL, Galan RF. Information gain in the brain’s resting state: a new perspective on autism. Front Neuroinformatics. 2013; 7: 37. DOI: 10.3389/ fninf.2013.00037

36. Motter A, Albert R. Networks in motion. Phys Today. 2012; 65 (4): 43–8. DOI: 10.1063/PT.3.1518

37. Lippe S, Kovacevic N, McIntosh AR. Di erential maturation of brain signal complexity in the human auditory and visual system. Front Hum Neurosci. 2009; 3: 48. DOI: 10.3389/neuro.09.048.2009

38. Takahashi T. Complexity of spontaneous brain activity in mental disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2013; 45: 258–66. DOI: 10.1016/j.
pnpbp.2012.05.001

39. Catarino A, Churches O, Baron-Cohen S, et al. Atypical EEG complexity in autism spectrum conditions: a multiscale entropy analysis. Neurophysiol Clin. 2011; 122 (12): 2375–83. DOI: 10.1016/j.clinph.2011.05.004

40. Wen D, Zhou Y, Li X. A critical review: coupling and synchronization analysis methods of EEG signal with mild cognitive impairment. Front Aging Neurosci. 2015; 7: 54. DOI: 10.3389/fnagi.2015.00054

41. Rapp PE, Keyser DO, Albano A, et al. Traumatic brain injury detection using electrophysiological methods. Front Hum Neurosci. 2015; 9: 11. DOI: 10.3389/ fnhum.2015.00011

42. Tierney AL, Gabard-Durnam L, Vogel-Farley V, et al. Developmental trajectories of resting EEG power: an endophenotype of autism spectrum disorder. PLoS One. 2012; 7: e39127. DOI: 10.1371/journal.pone.0039127

43. Levin AR, Varcin KJ, O’Leary HM, et al. EEG Power at 3 Months in Infants at High Familial Risk for Autism. Journal of Neurodevelopmental Disorders. 2017; 9: 1–13. DOI: 10.1186/s11689-017-9214-9

44. Chan AS, Leung WW. Di erentiating autistic children with quantitative encephalography: a 3-month longitudinal study. J Child Neurol. 2006; 21 (5): 391–9. DOI: 10.1177/08830738060210050501

45. Sheikhani A, Behnam H, Noroozian M, et al. Abnormalities of quantitative electroencephalography in children with Asperger disorder in various conditions. Res Autism Spectr Disord. 2009; 3 (2): 538–46. DOI: 10.1016/j.rasd.2008.11.002

46. Van Diessen E, Senders J, Jansen FE, et al. Increased power of resting-state gamma oscillations in autism spectrum disorder detected by routine electroencephalography. Eur Arch Psychiatry Clin Neurosci. 2015; 265 (6): 537–40. DOI: 10.1007/ s00406-014-0527-3

47. Stroganova TA, Nygren G, Tsetlin MM, et al. Abnormal EEG lateralization in boys with autism. Neurophysiol Clin. 2007; 118 (8): 1842–54. DOI: 10.1016/j. clinph.2007.05.005

48. Lushchekina E, Podreznaya E, Lushchekin V, et al. Comparative studies of EEG theta and gamma rhythms in normal children and children with early childhood autism. Neurosci Behav Physiol. 2014; 44 (8): 902–8. DOI: 10.1007/s11055-014-9999-x

49. Якупова Л.П., Симашкова Н.В. Связь нарушений ЭЭГ с клиническими особенностями расстройств аутистического спектра // Вестник совета молодых ученых и специалистов Челябинской области. ― 2016. ― Т. 3, No2. ― С.134-7. [Yakupova LP, Simashkova NV. Svyaz narusheniy EEG s klinicheskimi osobennostyami rasstroystv autisticheskogo spektra [Communication of EEG disturbances with clinical features of autism spectrum disorders]. Vestnik soveta molodykh uchenykh i spetsialistov Chelyabinskoy oblasti [Bulletin of the Council of Young Scientists and Specialists of the Chelyabinsk Region]. 2016; 3 (2): 134-7 (in Russ.)].

50. Najjar R, Brooker RJ. Delta-beta coupling is associated with paternal caregiving behaviors during preschool. Int J Psychophysiol. 2017; 112: 31-39. DOI: 10.1016/j. ijpsycho.2016.11.014

51. Kujawa A, Brooker RJ. Methods and metrics for EEG/ERP assessment of emotion and cognition in young children. Dev Psychobiol. 2022; 64 (6): e22284. DOI: 10.1002/dev.22284

52. Gasser T, Verleger R, Bächer P, et al. Development of the EEG of school-age children and adolescents. I. Analysis of band power. Electroencephalogr Clin Neurophysiol. 1988; 69 (2): 91–9. DOI: 10.1016/0013-4694(88)90205-2

53. Гамирова Р.Г., Горобец Е.А., Ахутина Т.В., Есин Р.Г. Влияние противоэпилептических средств на когнитивные функции у детей и подростков // Российский вестник перинатологии и педиатрии. – 2018. – Т. 63, No5. - C.130-134. [Gamirova RG, Gorobets EA, Ahutina TV, Esin RG. Vliyaniye protivoepilepticheskikh sredstv na kognitivnyye funktsii u detey i podrostkov [Impact of Antiepileptic Drugs on Cognitive Functions in Children and Adolescents]. Ros Vestn Perinatol i Pediatr [Russian Bulletin of Perinatology and Pediatrics]. 2018; 63 (5): 130–134 (in Russ.)]. DOI: 10.21508/1027– 4065–2018–63–5–130–134

54. Arzy S, Allali G, Brunet D, et al. Antiepileptic drugs modify power of high EEG frequencies and their neural generators. Eur J Neurol. 2010; 17 (10): 1308–12. DOI: 10.1111/j.1468-1331.2010.03018.x

55. Orekhova EV, Elsabbagh M, Jones EJH, et al. EEG hyper-connectivity in high-risk infants is associated with later autism. J Neurodev Disord. 2014; 6 (1): 1–11. DOI: 10.1186/1866-1955-6-40

56. Cantor DS, Thatcher RW, Hrybyk M, et al. Computerized EEG analyses of autistic children. J Autism Dev Disord. 1986; 16 (2): 169–87. DOI: 10.1007/BF01531728

57. Buckley AW, Scott R, Tyler A, et al. State-dependent di erences in functional connectivity in young children with autism spectrum disorder. EBioMedicine. 2015; 2 (12): 1905–15. DOI: 10.1016/j.ebiom.2015.11.004

58. Murias M, Webb SJ, Greenson J, et al. Resting state cortical connectivity re ected in EEG coherence in individuals with autism. Biol Psychiatry. 2007; 62 (3): 270–3. DOI: 10.1016/j.biopsych.2006.11.012

59. Coben R, Clarke AR, Hudspeth W, et al. EEG power and coherence in autistic spectrum disorder. Neurophysiol Clin. 2008; 119 (5): 1002–9. DOI: 10.1016/j.clinph.2008.01.013

60. Costa M, Goldberger AL, Peng CK. Multiscale entropy analysis of biological signals. Phys Rev E Stat Nonlin Soft Matter Phys. 2005; 71 (2): 021906. DOI: 10.1103/ PhysRevE.71.021906

61. Al-Fahoum AS, Al-Fraihat AA. Methods of EEG signal features extraction using linear analysis in frequency and time-frequency domains. ISRN Neurosci. 2014; 2014: 730218. DOI: 10.1155/2014/730218

62. Billeci L, Sicca F, Maharatna K, et al. On the application of quantitative EEG for characterizing autistic brain: a systematic review. Front Hum Neurosci. 2013. 5 (7): 442.DOI: 10.3389/fnhum.2013.00442

63. Okazaki R, Takahashi T, Ueno K, et al. Changes in EEG complexity with electroconvulsive therapy in a patient with autism spectrum disorders: a multiscale entropy approach. Front Hum Neurosci. 2015; 9: 106. DOI:
10.3389/fnhum.2015.00106

64. Catarino A, Churches O, Baron-Cohen S, et al. Atypical EEG complexity in autism spectrum conditions: a multiscale entropy analysis. Neurophysiol Clin. 2011; 122 (12): 2375–83. DOI: 10.1016/j.clinph.2011.05.004

65. Eldridge J, Lane AE, Belkin M, et al. Robust features for the automatic identi cation of autism spectrum disorder in children. J Neurodev Disord. 2014; 6 (1): 12. DOI: 10.1186/1866-1955-6-12

66. Ahmadlou M, Adeli H, Adeli A. Fractality and a wavelet-chaos-neural network methodology for EEG-based diagnosis of autistic spectrum disorder. J Clin Neurophysiol. 2010; 27 (5): 328–33. DOI: 10.1097/ WNP.0b013e3181f40dc8

67. Bosl WJ, Tager-Flusberg H, Nelson CA. EEG Analytics for Early Detection of Autism Spectrum Disorder: A data-driven approach. Sci Rep. 2018; 8 (1): 6828. DOI: 10.1038/s41598-018-24318-x

68. Tager-Flusberg H. The origins of social impairments in autism spectrum disorder: studies of infants at risk. Neural Networks. 2010; 23 (8-9): 1072-6. DOI: 10.1016/j.neunet.2010.07.008

69. Gurau O, Bosl WJ, Newton CR. How Useful Is Electroencephalography in the Diagnosis of Autism Spectrum Disorders and the Delineation of Subtypes: a Systematic Review. Front Psychiatry. 2017; 8: 121. DOI: 10.3389/fpsyt.2017.00121

70. Gao Z, Jin N. Complex network from time series based on phase space reconstruction. Chaos. 2009; 19: 033137. DOI: 10.1063/1.3227736

71. Andreou M, Skrimpa V. Theory of Mind De cits and Neurophysiological Operations in Autism Spectrum Disorders: a Review. Brain Sci. 2020; 10 (6): 393. DOI: 10.3390/brainsci10060393

72. Oberman LM, Hubbard EM, McCleery JP, et al. EEG evidence for mirror neuron dysfunction in autism spectrum disorders. Brain Res Cogn Brain Res. 2005; 24 (2): 190-8. DOI: 10.1016/j.cogbrainres.2005.01.014

73. Williams JH. Self-other relations in social development and autism: multiple roles for mirror neurons and other brain bases. Autism Res. 2008; 1 (2): 73-90. DOI: 10.1002/aur.15

74. Raymaekers R, Wiersema JR, Roeyers H. EEG study of the mirror neuron system in children with high functioning autism. Brain Res. 2009; 1304: 113-21. DOI: 10.1016/j.brainres.2009.09.068

75. Aaronson B, Estes A, Rogers SJ, et al. The Early Start Denver Model Intervention and Mu Rhythm Attenuation in Autism Spectrum Disorders. J Autism Dev Disord. 2022; 52 (7): 3304-3313. DOI: 10.1007/s10803-021-05190-7

76. Кайда А.И., Михайлова А.А., Эйсмонт Е.В. и др. Реактивность μ-ритма ЭЭГ у детей при имитации движений визуальных образов биологического и небиологического происхождения // Вестник Россий-ского государственного медицинского университета. – 2020. – No2. – С.67–75. [Kayda AI, Mikhaylova AA, Eysmont EV, et al. Reaktivnost μ -ritma EEG u detey pri imitatsii dvizheniy vizualnykh obrazov biologicheskogo i nebiologicheskogo proiskhozhdeniya [EEG μ-rhythm reactivity in children during imitation pf biological and non-biological motion]. Vestnik Rossiyskogo gosudarstvennogo meditsinskogo universiteta [Bulletin of Russian State Medical University]. 2020; 2: 67-75 (in Russ.)]. DOI: 10.24075/vrgmu.2020.019

77. Holtmann M, Steiner S, Hohmann S, et al. Neurofeedback in autism spectrum disorders. Dev Med Child Neurol. 2011; 53 (11): 986-93. DOI: 10.1111/j.1469-8749.2011.04043.x

78. Bernier R, Dawson G, Webb S, et al. EEG mu rhythm and imitation impairments in individuals with autism spectrum disorder. Brain and Cognition. 2007; 64 (3): 228-237. DOI: 10.1016/j.bandc.2007.03.004

79. Gyawali S, Patra BN. Autism spectrum disorder: trends in research exploring etiopathogenesis. Psychiatry Clin Neurosci. 2019; 73 (8): 466-475. DOI: 10.1111/ pcn.12860

80. Rapp PE, Keyser DO, Albano A, et al. Traumatic brain injury detection using electrophysiological methods. Frontiers in human neuroscience. 2015; 9:11. DOI: 10.3389/fnhum.2015.00011

81. Белоусова М.В., Гамирова Р.Г., Прусаков В.Ф. Клинико-электроэнцефалографические особенности детей с расстройствами аутистического спектра, имеющих речевые нарушения // Сибирский вестник психиатрии и наркологии. -2014 – Т.3, No 84. - С. 38-42. [Belousova MV, Gamirova RG, Prusakov VF. Kliniko-elektroencefalogra cheskie osobennosti detej s rasstrojstvami autisticheskogo spektra, imeyushchih rechevye narusheniya [Clinical and electroencephalographic features of children with autism and speech disorders] Sibirskij vestnik psihiatrii i narkologii [Siberian Bulletin of Psychiatry and Narcology]. 2014; 3 (84): 38-42 (in Russ.)]. https:// elibrary.ru/download/elibrary_22456206_18314950.pdf

 

UDC 611.621:612.062

DOI: 10.20969/VSKM.2023.16(2).89-94

PDF download FEATURES OF NEUROTRANSMITTER REGULATION OF URETERAL FUNCTION AND PROSPECTS FOR THE SEARCH FOR NEW STONE-REMOVING DRUGS

ZYAPBAROV AINUR M., ORCID ID: 0000-0001-8388-9172; postgraduate student Department of Pharmacology of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49; e-mail: zyapbarov43@gmail.com

ZIGANSHIN AYRAT U., ORCID ID: 0000-0002-9087-7927; D. Med. Sci., professor., Head of the Department of Pharmacology, Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49; e-mail: ayrat.ziganshin@ kazangmu.ru

Abstract. Introduction. The study of the neurotransmitter regulation of the ureters allows a better understanding of the function of the ureters, not only in the norm, but also the mechanism of development of renal colic, one of the most common acute conditions in urology. Moreover, the main type of treatment for renal colic is drug therapy used to relieve pain, as well as drug stone expelling therapy, which is gradually replenished with new drugs. Aim. The aim of the study is to review current information on the neurotransmitter regulation of the ureters. Material and Methods. A review current information on the neurotransmitter regulation of the ureters was carried out. Results and discussion. To date, the role of alpha- and beta-adrenergic receptors, cholinergic receptors is the most studied, the mechanism of action of cyclooxygenase inhibitors and Ca channel blockers is also well studied. Drugs belonging to the above groups continue to be widely and successfully used in clinical practice, including in emergency urology, and also continue to be replenished with new representatives of these groups of medicines. Recently, new clinical data have appeared on the e ectiveness of the use of type 5 phosphodiesterase inhibitors, and the role of serotonin receptors in the ureters continues to be studied. Another interesting area is the study of the role of P2 receptors in normal and pathological conditions. The wide expression of all known P2 receptor subtypes on ureteral cells, as well as the release of adenosine triphosphoric acid by urothelial cells with an increase in intraureteral pressure, suggests their important role in the contractile activity of the ureters. Conclusion. The impact on the P2 receptors of the ureters can become one of the promising areas for the search and development of new stone-removing drugs with a new mechanism of action. The article discusses the roles of the above receptors and enzymes in the neurotransmitter regulation of the ureters.

Key words: neurotransmitter regulation of the ureters, P2 receptors, urothelium, stone expulsion therapy, receptor expression.
For reference: Zyapbarov AM, Ziganshin AU. Features of neurotransmitter regulation of ureteral function and prospects for the search for new stone-removing drugs. The Bulletin of Contemporary Clinical Medicine. 2023; 16(2): 89-94. DOI: 10.20969/VSKM.2023.16(2).89-94.

References

  1. Corbo J, Wang J. Kidney and ureteral stones. Emerg Med Clin North Am. 2019; 37(4): 637-648. DOI: 10.1016/j.emc.2019.07.004
  2. Manchanda R, Appukattan S, Padmakumar M. Electrophysiology of Syncytial Smooth Muscle. Journal of Experimental Neuroscience. 2019; 13: 1-16. DOI: 10.1177/1179069518821917
  3. Abbracchio MP, Williams M. Purinergic and Pyrimidinergic signalling I. Springer. 2001; 526 p. ISBN 3-540-67849-2
  4. Vernez SL, Okhunov Z, Wikenheiser J, et al. Precise characterization and 3-dimensional reconstruction of the autonomic nerve distribution of the human ureter. J Urol. 2017; 197 (3 Pt1): 723-729. DOI: 10.1016/j. juro.2016.08.118
  5. Lim I, Sellers DJ, Chess-Williams R. Current and emerging pharmacological targets for medical expulsive  therapy. J Basic Clin Pharmacol Toxicol. 2022; 130 (1): 16-22. DOI: 10.1111/bcpt.13613

  1. Michel MC, Ochodnicky P, Homma Y, Igawa Y. Beta-adrenoreceptor agonist e ects in experimental models of bladder dysfunction. Pharmacol Ther. 2011; 131(1): 40-49. DOI: 10.1016/j.pharmthera.2011.03.014

  2. Pezzone MA, Watkins SC, Alber SM, et al. Identi cation of c-kit-positive cells in the mouse ureter: the interstitial cells of Cajal of the urinary tract. Am J Physiol Renal Physiol. 2003; 284(5): 925-929. DOI: 10.1152/ ajprenal.00138.2002

  3. Lee HW, Baak CH, Lee MY, Kim YC. Spontaneous contractions augmented by cholinergic and adrenergic systems in the human ureter. Korean J Physiol Pharmacol. 2011; 15(1): 37-41. DOI: 10.4196/ kjpp.2011.15.1.37

  4. Metzger R, Schuster T, Till H, et al. Cajal-like cells in the human upper urinary tract. J Urol. 2004; 172(2): 769-772. DOI: 10.1097/01.ju.0000130571.15243.59

  5. Lee HW, Baak CH, Lee MY, Kim YC. Spontaneous contractions augmented by cholinergic and adrenergic systems in the human ureter. Korean J Physiol Pharmacol. 2011; 15 (1): 37-41. DOI: 10.4196/ kjpp.2011.15.37

  6. Hatton WJ, Mason HS, Carl A, et al. Functional and molecular expression of a voltage-dependent K (+) channel in interstitial cells of Cajal. J Physiol. 2001; 533 (Pt 2): 315-327. DOI: 10.1111/j.1469-7793.2001.0315a.x

  7. Raz S, Zeigler M, Caine M. Hormonal in uence on the adrenergic receptors of the ureter. Br J Urol. 1972; 44 (4): 405-410. DOI: 10.1111/j.1464-410x.1972.tb10100.x

  8. Hernandez M, Prieto D, Simonsen U, et al. Noradrenaline modulates smooth muscle activity of the isolated intravesical ureter of the pig through di erent types of adrenoceptors. Br J Pharmacol. 1992; 107 (4): 924-931. DOI: 10.1111/j.1476-5381.1992.tb13387

  9. Park HK, Choi EY, Jeong BC, et al. Localizations and expressions of alpha-1A, alpha-1B and alpha-1D adrenoreceptors in human ureter . Urol Res. 2007; 35 (6): 325-329. DOI: 10.1007/s00240-007-0118-0

  10. Sasaki S, Tomiyama Y, Kobayashi S, et al. Characterization of alpha1-adrenoreceptor subtypes mediating contraction in human isolated ureters. Urology. 2011; 77 (3): 13-17. DOI: 10.1016/j. urology.2010.09.034

  11. Villa L, Buono R, Fossati N, et al. E ects by silodosin on the partially obstructed rat ureter in vivo and on human and rat isolated ureters. Brit J Pharmacol. 2013; 169 (1): 230-238. DOI: 10.1111/bph.12123

  12. Abrams PH, Feneley RC. The actions of prostaglandins on the smooth muscle of the human urinary tract in vitro. Br J Urol. 1975; 47 (7): 909-915. DOI: 10.1111/j.1464-410x.1975.tb04075.x

  13. Wanajo I, Tomiyama Y, Yamazaki Y, et al. Pharmacological characterization of beta-adrenoceptor subtypes mediating relaxation in porcine isolated ureteral smooth muscle. J Urol. 2004; 172 (3): 1155-1159. DOI: 10.1097/01.ju.0000133557.39515.b6

  14. Gidener S, Gumustekin M, Kirkali Z. Pharmacological analysis of 5-hydroxytryptamine e ects on human isolated ureter. Pharmacol Res. 1999; 39 (6): 487-491. DOI: 10.1006/phrs.1999.0469

20. Tomiyama Y, Murakami M, Hayakawa K, et al. Pharmacological pro le of KUL-7211, a selective beta-adrenoceptor agonist, in isolated ureteral smooth. J Pharmacol Sci. 2003; 92 (4): 411-419. DOI: 10.1254/ jphs.92.411

21. Cai D, Wei G, Wu P, et al. The e cacy of Mirabegron in medical expulsive therapy for ureteral stones: A systematic review and Meta-analysis. Int J Clin Pract. 2022; 2022:2293182. DOI: 10.1155/2022/2293182

22. Sakamoto K, Suri D, Rajasekaran M. Characterization of muscarinic receptor subtypes in human ureter. J Endourol. 2006; 20 (11): 939-942. DOI: 10.1089/ end.2006.20.939

23. Del Tacca M. Acetylcholine content of and release from isolated pelviureteral tract. Naunyn Schmiedebergs Arch Pharmacol. 1978; 302 (3): 293-297. DOI: 10.1007/ BF00508298

24. Hernandez M, Simonsen U, Prieto D, et al. Di erent muscarinic receptor subtypes mediating the phasic activity and basal tone of pig isolated intravesical ureter. Br J Pharmacol. 1993; 110 (4): 1413-1420. DOI: 10.1111/j.1476-5381.1993.tb13978.x

25. Gidener S, Gumustekin M, Kirkali Z. Pharmacological analysis of 5-hydroxytryptamine e ects on human isolated ureter. Pharmacol Res. 1999; 39 (6): 487-491. DOI: 10.1006/phrs.1999.0469

26. Hernandez M, Barahona MV, Simonsen U, et al. Characterization of the 5-hydroxytryptamine receptors mediating contractions in the pig isolated intravesical ureter. Brit J Pharmacol. 2003; 138 (1): 137-144. DOI: 10.1038/sj.bjp.0705019

27. Vodenicharov A, Leiser R, Gulubova M, Vlaykova T. Morphological and immunocytochemical investigations on mast cells in porcine ureter. Anat Histol Embryol. 2005; 34 (6): 343-349. DOI:10.1111/j.1439-0264.2005.00618.x

28. Forman A, Andersson KE, Henriksson L, et al. E ects of nifedipine on the smooth muscle of the human urinary tract in vitro and in vivo. Acta Pharmacol Toxicol (Copenh).1978; 43(2): 111-118. DOI: 10.1111/j.1600-0773.1978.tb02244.x

29. Troxel SA, Jones AW, Magliola L, Benson JS. Physiologic e ect of nifedipine and tamsulosin on contractility of distal ureter. J Endourol. 2006; 20(8): 565-568. DOI: 10.1089/end.2006.20.565

30. Porpiglia F, Ghignone G, Fiori C, et al. Nifedipine versus tamsulosin for the management of lower ureteral stones. J Urol. 2004; 172(2): 568-571. DOI: 10.1097/01.ju.0000132390.61756. 

31. Chiagnat V, Danuser H, Sto el M, et al. E ects of a non-selective COX inhibitor and selective COX-2 inhibitors on contractility of human and porcine ureters in vitro and in vivo. Brit J Pharmacol. 2008; 154(6): 1297-1307. DOI: 10.1038/bjp.2008.193

32. Abrams PH, Feneley RC. The actions of prostaglandins on the smooth muscle of the human urinary tract in vitro. Br J Urol. 1975; 47(7): 909-915. DOI: 10.1111/j.1464-410x.1975.tb04075.x

33. Angelo-Khattar M, Thulesius O, Nilsson T, et al. Motility of the human ureter, with special reference to the e ect  of indomethacin. Scand J Urol Nephrol. 1985; 19(4): 261-265. DOI: 10.3109/0036598509180267

  1. Nakada SY, Jerde TJ, Bjorling DE, Saban R. Selective cyclooxygenase-2 inhibitors reduce ureteral contraction in vitro: a better alternative for renal colic? J Urol. 2000; 163(2): 607-612. https://pubmed.ncbi.nlm.nih.gov/10647695/

  2. Lim I, Chess-Williams R, Sellers DJ. A porcine model of ureteral contractile activity: In uences of age, tissue orientation, region, urothelium, COX and NO. J Pharmacol Toxicol Methods. 2020; 102:106661. DOI: 10.1016/j.vascn.2019.106661

  3. Stief CG, Taher A, Truss M, et al. Phosphodiesterase isoenzymes in human ureteral smooth muscle: identi cation, characterization and functional e ects of various phosphodiesterase inhibitors in vitro. Urol Int. 1995; 55(4): 183-189. DOI: 10.1159/000282783

  4. Gratzke C, Uckert S, Kedia G, et al. In vitro e ects of PDE5 inhibitors sildena l, vardena l and tadala l on isolated human ureteral smooth muscle: a basic research approach. Urol Res. 2007; 35(1): 49-54. DOI: 10.1007/s00240-006-0073-1

  5. Bai Y, Yang Y, Wang X, et al. Tadala l facilitates the distal ureteral stone expulsion: A Meta-analysis. J Endourol. 2017; 31(6): 557-563. DOI: 10.1089/end.2016.0837

  6. Зиганшин А.У., Зиганшина Л.Е. Р2-рецепторы: перспективная мишень для будущих лекарств: монография // Москва: ГЭОТАР-Медиа, 2009; 136 с. [Ziganshin AU, Ziganshina LE. P2-receptory: perspektivnaya mishen’ dlya budushchih lekarstv: monogra ya [Purine P2-receptors: a promising target for future drugs: monograph]. Moskva: GEOTAR-Media [Moscow: GEOTAR-Media]. 2009; 136 p. (In Russ.)] ISBN 978-5-9704-1501-6

  7. Burnstock G. Purinergic signalling: Its unpopular beginning, its acceptance and its exciting future. Bioessays. 2012; 34(3): 218-225. DOI: 10.1002/ bies.201100130

41. Ralevic V, Burnstock G. Receptors for purines and pyrimidines. Pharmacol Rev. 1998; 50(3): 413-492. https://pubmed.ncbi.nlm.nih.gov/9755289/

42. Birder L, Andersson K-E. Urothelial signaling. Physiol Rev. 2013; 93(2): 653-680. DOI: 10.1152/ physrev.00030.2012

43. Shabir S, Cross W, Kirkwood LA. Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. Am J Physiol Renal Physiol. 2013; 305(3): 396-406. DOI: 10.1152/ajprenal.00127.2013

44. Rong W, Burnstock G. Activation of ureter nociceptors by exogenous and endogenous ATP in guinea pig. Neuropharmacology. 2004; 47(7): 1093-1101. DOI: 10.1016/j.neuropharm.2004.08.003

45. Lee HY, Bardini M, Burnstock G. Distribution of P2X receptors in the urinary bladder and the ureter of the rat. J Urol. 2000; 163(6): 2002-2007. https://pubmed. ncbi.nlm.nih.gov/10799247/

46. Burnstock G. Purinergic mechanosensory transduction and visceral pain. Mol Pain. 2009; 5: 69-81. DOI: 10.1186/1744-8069-5-69

47. Risholm L. Studies on renal colic and its treatment by posterior splanchnic block. Acta Chir Scand. 1954; 184: 5-64. https://pubmed.ncbi.nlm.nih.gov/13137835/

48. Calvert RC, Thompson CS, Burnstock G. ATP release from the human ureter on distension and P2X3 receptor expression on suburothelial sensory nerves. Purinergic Signalling. 2008; 4(4): 377-381. DOI: 10.1007/s11302-008-9132-1

49. Canda AE, Turna B, Cinar GM, Nazli O. Physiology and pharmacology of the human ureter: basis for current and future treatments. Urol Int. 2007; 78(4): 289-298. DOI: 10.1159/000100830

 

UDC 614.273:615.15

DOI: 10.20969/VSKM.2023.16(2).95-101

PDF download THE IMPACT OF STATE INSTITUTIONAL NORMS ON THE MANAGEMENT OF THE RANGE POLICY OF ORGANIZATIONS WHOLESALE MEDICINES

URUSOVA LEYLA K., ORCID ID: 0000-0002-4829-2642, postgraduate student of the Department of Pharmacy, Pyatigorsk Medical and Pharmaceutical Institute – branch of the Volgograd State Medical University, Russia, Pyatigorsk, Kalinina Avenue 11, e -mail: flora0996@mail.ru

GORYACHEV ANDREY B., ORCID ID: 0000-0002-6844-4578, Scopus author ID: 25642462600, Dr. Pharm. Sci., Associate Professor, Professor of the Department of Life Safety and Disaster Medicine, Sechenov First Moscow State Medical University, Russia, 119991, Moscow, st. Trubetskaya 8, building 2, e-mail: abgor61@gmail.com

KABAKOVA TAISIA I., ORCID ID: 0000-0001-6182-5637, Scopus author ID: 57207985290, Dr. Pharm. Sci., Associate Professor, Professor of the Department of Management and Economics in Pharmacy, Pyatigorsk Medical and Pharmaceutical Institute –branch of the Volgograd State Medical University, Russia, Pyatigorsk, Kalinina Avenue 11, e -mail: kabtais@mail.ru

Abstract. Introduction. Continuous analysis of regulatory norms and their implementation is a signi cant factor that a ects the e ciency of the wholesale segment of the pharmaceutical market in the dynamically evolving legal eld. Aim. Summarize and analyze state institutional norms that a ect the processes of managing the assortment policy of drug wholesalers in the modern pharmaceutical market. Material and Methods. The object of the study was the regulatory legal acts that in uence the formation and management of the assortment policy in the wholesale segment of the pharmaceutical market. In the course of the work, methods of documentary observation and comparison, content analysis of legislative acts and regulatory legal documents were used. Results and discussion. It was revealed that the formation of the medicinal assortment is signi cantly in uenced by institutional norms that determine the procedure for the circulation of medicines (state regulation of maximum selling prices, preferential provision of medicines for decreed groups of citizens, and others). It has been established that institutional norms, on the one hand, provide a guaranteed demand for pharmaceutical products of a reduced range, and on the other hand, limit pro ts due to state regulation of selling prices. However, the share of goods of this assortment does not exceed 15-20% in terms of the number of inventory units and 25% in terms of wholesale sales, which allows us to provide a stable, complete assortment with a high turnover and pro table commercial activity. Conclusion. Thus, state institutional norms have a signi cant impact on the formation of the product range of Russian pharmaceutical distributors, but this does not undermine the pro tability of their economic activities and ensures the social responsibility of the business.

Key words: drugs, product range, pharmaceutical distributor, wholesale trade, institutional norms.

For reference: Urusova LKh, Goryachev AB, Kabakova TI. The impact of state institutional norms on the management of the range policy of organizations wholesale medicines. The Bulletin of Contemporary Clinical Medicine. 2023; 16(2): 95-101. DOI: 10.20969/VSKM.2023.16(2).95-101.

References

  1. Федеральный закон от 28.12.2009 No 381-ФЗ «Об основах государственного регулирования торговой деятельности в Российской Федерации». [Federal’nyj zakon ot 28.12.2009 No 381-FZ «Ob osnovah gosudarstvennogo regulirovaniya torgovoj deyatel’nosti v Rossijskoj Federacii» [Federal Law No. 381-FZ of December 28, 2009 “On the Fundamentals of State Regulation of Trading Activities in the Russian Federation”]. (In Russ)]. https://www.consultant.ru/ document/cons_doc_LAW_95629/

  2. Федеральный закон от 12.04.2010 No 61-ФЗ «Об обращении лекарственных средств». [Federal’nyj zakon ot 12.04.2010 No 61-FZ «Ob obrashchenii lekarstvennyh sredstv» [Federal Law No. 61-FZ of April 12, 2010 “On the Circulation of Medicines”]. (In Russ)]. https://www.consultant.ru/document/cons_ doc_LAW_99350/

  3. Решение Совета Евразийской экономической комиссии от 03.11.2016 No 80 «Об утверждении Правил надлежащей дистрибьюторской практики в рамках Евразийского экономического союза». [Reshenie Soveta Evrazijskoj ekonomicheskoj komissii ot 03.11.2016 No 80 «Ob utverzhdenii Pravil nadlezhashchej distrib’yutorskoj praktiki v ramkah Evrazijskogo ekonomicheskog soyuza» [Decision of the Council of the Eurasian Economic Commission dated 03.11.2016 No. 80 “On approval of the Rules for Good Distribution Practice within the Eurasian Economic Union”]. (In Russ)]. https://www.consultant. ru/document/cons_doc_LAW_207404/

  4. Федеральный закон от 04.05.2011 No 99-ФЗ «О лицензировании отдельных видов деятельности». [Federal’nyj zakon ot 04.05.2011 No 99-FZ «O licenzirovanii otdel’nyh vidov deyatel’nosti» [Federal Law No. 99-FZ dated 04.05.2011 “On Licensing Certain Types of Activities”]. (In Russ)]. https://www.consultant. ru/document/cons_doc_LAW_113658/

  5. Постановление Правительства РФ от 31.03.2022 No 547 «Об утверждении Положения о лицензировании фармацевтической деятельности». [Postanovlenie Pravitel’stva RF ot 31.03.2022 No 547 «Ob utverzhdenii Polozheniya o licenzirovanii farmacevticheskoj deyatel’nosti» [Decree of the Government of the Russian Federation of March 31, 2022 No. 547 “On Approval of the Regulation on Licensing Pharmaceutical Activities”]. (In Russ)]. https://www.consultant.ru/ document/cons_doc_LAW_413815/

  6. Распоряжение Правительства РФ от 12.10.2019 No 2406-р (ред. от 06.10.2022) «Об утверждении перечня жизненно необходимых и важнейших лекарственных препаратов, а также перечней лекарственных препаратов для медицинского применения и минимального ассортимента лекарственных препаратов, необходимых для оказания медицинской помощи». [Rasporyazhenie Pravitel’stva RF ot 12.10.2019 No 2406-r (red. ot 06.10.2022) «Ob utverzhdenii perechnya zhiznenno neobhodimyh i vazhnejshih lekarstvennyh preparatov, a takzhe perechnej lekarstvennyh preparatov dlya medicinskogo primeneniya i minimal’nogo assortimenta lekarstvennyh preparatov, neobhodimyh dlya okazaniya medicinskoj pomoshchi» [Decree of the Government of the Russian Federation of October 12, 2019 No. 2406-r (as amended on October 6, 2022) “On approval of the list of vital and essential medicines, as well as the lists of medicines for medical use and the minimum range of medicines necessary for the provision of medical care”]. (In Russ)]. https://www.consultant.ru/document/ cons_doc_LAW_335635/

  7. Постановление Правительства РФ от 15.09.2015 No 979 (ред. от 31.10.2020) «Методика расчета предельных отпускных цен производителей на лекарственные препараты, включенные в перечень жизненно необходимых и важнейших лекарственных препаратов». [Postanovlenie Pravitel’stva RF ot 15.09.2015 No 979 (red. ot 31.10.2020) «Metodika rascheta predel’nyh otpusknyh cen proizvoditelej nalekarstvennye preparaty, vklyuchennye v perechen’ zhiznenno neobhodimyh i vazhnejshih lekarstvennyh preparatov» [Decree of the Government of the Russian Federation of September 15, 2015 No. 979 (as amended on October 31, 2020) “Methodology for calculating the maximum selling prices of manufacturers for medicines included in the list of vital and essential medicines”]. (In Russ)]. https://www.consultant.ru/document/cons_ doc_LAW_186127/

  8. Приказ ФАС России от 09.09.2020 No 820/20 «Об утверждении Методики установления органами исполнительной власти субъектов Российской Федерации предельных размеров оптовых надбавок и предельных размеров розничных надбавок к фактическим отпускным ценам, установленным производителями лекарственных препаратов, на лекарственные препараты, включенные в перечень жизненно необходимых и важнейших лекарственных препаратов». [Prikaz FAS Rossiiot 09.09.2020 No 820/20 «Ob utverzhdenii Metodiki ustanovleniya organami ispolnitel’noj vlasti sub»ektov Rossijskoj Federacii predel’nyh razmerov optovyh nadbavok i predel’nyh razmerov roznichnyh nadbavok k fakticheskim otpusknym cenam, ustanovlennym proizvoditelyami lekarstvennyh preparatov, na lekarstvennye preparaty, vklyuchennye v perechen’ zhiznenno neobhodimyh i vazhnejshih lekarstvennyh preparatov» [Order of the Federal Antimonopoly Service of Russia dated 09.09.2020 No. 820/20 “On Approval of the Methodology for Setting the Limits of Wholesale Markups and Limits of Retail Markups by the Executive Authorities of the Subjects of the Russian Federation to the Actual Selling Prices Set by Manufacturers of Medicinal Products for Medicinal Products Included in the List life-saving and essential medicines”]. (In Russ)]. https://www.consultant.ru/ document/cons_doc_LAW_362490/

  1. Федеральный закон от 17.07.1999 No 178-ФЗ «О государственной социальной помощи». [Federal’nyj zakon ot 17.07.1999 No 178-FZ «O gosudarstvennoj social’noj pomoshchi» [Federal Law of July 17, 1999 No. 178-FZ “On State Social Assistance”]. (In Russ)]. https://www.consultant.ru/document/cons_doc_ LAW_23735/

  2. Федеральный закон от 21.11.2011 No 323-ФЗ «Об основах охраны здоровья граждан в Российской Федерации». [Federal’nyj zakon ot 21.11.2011 No 323-FZ «Ob osnovah ohrany zdorov’ya grazhdan v Rossijskoj Federacii» [Federal Law No. 323-FZ of November 21, 2011 “On the Fundamentals of Protecting the Health of Citizens in the Russian Federation”]. (In Russ.)]. http:// www.consultant.ru/document/cons_doc_LAW_121895

  3. Постановление Правительства РФ от 26.11.2018 No 1416 (ред. от 26.06.2021) «О порядке организации обеспечения лекарственными препаратами лиц, больных гемофилией, муковисцидозом, гипофизарным нанизмом, болезнью Гоше, злокачественными новообразованиями лимфоидной, кроветворной и родственных им тканей, рассеянным склерозом, гемолитико-уремическим синдромом, юношеским артритом с системным началом, мукополисахаридозом I, II и VI типов, апластической анемией неуточненной, наследственным дефицитом факторов II (фибриногена), VII (лабильного), X (Стюарта Прауэра), лиц после трансплантации органов и (или) тканей, а также о признании утратившими силу некоторых актов Правительства Российской Федерации». [PostanovleniePravitel’stva RF ot 26.11.2018 No 1416 (red. ot 26.06.2021) «O poryadke organizacii obespecheniya lekarstvennymi preparatami lic, bol’nyh gemo liej, mukoviscidozom, gipo zarnym nanizmom, bolezn’yu Goshe, zlokachestvennymi novoobrazovaniyami limfoidnoj, krovetvornoj i rodstvennyh im tkanej, rasseyannym sklerozom, gemolitiko-uremicheskim sindromom, yunosheskim artritom s sistemnym nachalom, mukopolisaharidozom I, II i VI tipov, aplasticheskoj anemiej neutochnennoj, nasledstvennym de citom faktorov II ( brinogena), VII (labil’nogo), X (Styuarta Prauera), lic posle transplantacii organov i (ili) tkanej, a takzhe o priznanii utrativshimi silu nekotoryh aktov Pravitel’stva Rossijskoj Federacii» [Decree of the Government of the Russian Federation of November 26, 2018 No. 1416 (as amended on June 26, 2021) “On the procedure for organizing the provision of medicines to persons with hemophilia, cystic brosis, pituitary dwar sm, Gaucher disease, malignant neoplasms of the lymphoid, hematopoietic and related tissues, multiple sclerosis, hemolytic uremic syndrome, juvenile arthritis with a systemic onset, mucopolysaccharidosis types I, II and VI, unspeci ed aplastic anemia, hereditary de ciency of factors II ( brinogen), VII (labile), X (Stuart-Prower), persons after organ transplantation and (or ) fabrics, as well as on the invalidation of certain acts of the Government of the Russian Federation”]. (In Russ.)]. https://www.consultant.ru/document/cons_doc_ LAW_311869/

  4. Приказ Минздрава России от 31.08.2016 No 647н «Об утверждении Правил надлежащей аптечной практики лекарственных препаратов для медицинского применения». [Prikaz Minzdrava Rossii ot 31.08.2016 No 647n «Ob utverzhdenii Pravil nadlezhashchej aptechnoj praktiki lekarstvennyh preparatov dlya medicinskogo primeneniya» [Order of the Ministry of Health of Russia dated August 31, 2016 No. 647n “On Approval of the Rules for Good Pharmacy Practice of Medicinal Products for Medical Use”]. (In Russ.)]. https://www.consultant.ru/document/ cons_doc_LAW_210618/

  5. Постановление Правительства РФ от 10.05.2007 No 280 «О федеральной целевой Программе «Предупреждение и борьба с социально значимыми заболеваниями (2007-2012 годы)». [Postanovlenie Pravitel’stva RF ot 10.05.2007 No 280 «O federal’noj celevoj Programme «Preduprezhdenie i bor’ba s social’no znachimymi zabolevaniyami (2007-2012 gody)» [Decree of the Government of the Russian Federation of May 10, 2007 No. 280 “On the Federal Target Program “Prevention and Control of Socially Signi cant Diseases (2007-2012)”]. (In Russ.)]. https:// base.garant.ru/4184672/

  6. Распоряжение Правительства РФ от 21.12.2020 No 3468-р «Об утверждении Государственной стратегии противодействия распространению ВИЧ-инфекции в Российской Федерации на период до 2030 года». [Rasporyazhenie Pravitel’stva RF ot 21.12.2020 No 3468-r «Ob utverzhdenii Gosudarstvennoj strategii protivodejstviya rasprostraneniyu VICh-infekcii v Rossijskoj Federacii na period do 2030 goda» [Decree of the Government of the Russian Federation of December 21, 2020 No. 3468-r “On Approval of the State Strategy to Combat the Spread of HIV Infection in the Russian Federation for the Period until 2030”]. (In Russ.)]. https://www.consultant.ru/document/cons_ doc_LAW_372322/

 

FROM PRACTICAL EXPERIENCE

UDC [616.43+616.1+616.24]:578.834.1:616-06

DOI: 10.20969/VSKM.2023.16(2).102-107

PDF download A CLINICAL CASE OF «LONG-COVID» WITH DAMAGE TO THE ENDOCRINE, CARDIOVASCULAR AND PULMONARY SYSTEMS

IVANOVA LIUDMILA A., ORCID ID: 0000-0001-5302-3802; D. Med. Sci., professor, Head of the Department of endocrinology of faculty of advanced training and professional specialist retraining of Kuban State Medical University, Russia, 350063, Krasnodar, Sedin str., 4, e-mail: endocrinkgmu@mail.ru

KOVALENKO YULIYA S., ORCID ID: 0000-0002-7236-7341; С. Med. Sci., Associate Professor, Head of the Department of endocrinology of faculty of advanced training and professional specialist retraining of Kuban State Medical University, Russia, 350063, Krasnodar, Sedin str., 4, e-mail: julendo@mail.ru

KOROL INNA V., ORCID ID: 0000-0002-3909-9007; C. Med. Sci., Associate Professor of the Department of endocrinology of faculty of advanced training and professional specialist retraining of Kuban State Medical University, Russia, 350063, Krasnodar, Sedin str., 4, e-mail: innakorol1@mail.ru

SMEZINOVA ANNA V., ORCID ID: 0000-0003-3698-5924, Assistant Professor of the Department of endocrinology of faculty of advanced training and professional specialist retraining of Kuban State Medical University, Russia, 350063, Krasnodar, Sedin str., 4, e-mail: nanun1971@yandex.ru

KOKOVA YEVGENIYA A., ORCID ID: 0000-0002-7236-7341, endocrinologist of the clinic Kuban State Medical University, Russia, 350042, Krasnodar, Zipovskaya str., 4/1, e-mail: zelenova2007@mail.ru

ANANEVA ELENA I., ORCID ID: 0000-0002-0781-1258, clinical resident of the Department of endocrinology of faculty of advanced training and professional specialist retraining of Kuban State Medical University, Russia, 350063, Krasnodar, Sedin str., 4, e-mail: elenaananevaa@gmail.com

Abstract. Introduction. Coronavirus infection caused by the SARS-CoV-2 virus is characterized by a large range of clinical manifestations, which is associated with the presence of angiotensin-converting enzyme-2 receptors in many organs and tissues of the body. Subacute thyroiditis induced by COVID-19 is di cult to recognize due to the frequent absence of classical symptoms of thyroiditis. Aim. Demonstrate the features of the clinical course of a new coronavirus infection complicated by subacute thyroiditis and pericarditis in the distant period. Material and Methods. A clinical case of patient K., 56 years old, with damage to the pulmonary, cardiovascular and endocrine systems as a result of a new coronavirus infection was presented. Results and discussion. Subacute thyroiditis as a result of SARS-CoV-2 infection may have an atypical course. A pathognomonic feature of subacute thyroiditis is the high rate of erythrocyte sedimentation. The treatment of subacute thyroiditis in most cases requires the prescription of glucocorticoids. In some patients, prescribing nonsteroidal anti-in ammatory drugs may be su cient to relieve symptoms. There was no clear association of cardiovascular symptoms in long-term COVID-19 with pre-existing cardiovascular pathology..Conclusion. In the case of subacute thyroiditis developed as a result of SARS-CoV-2 infection, it is necessary to prescribe anti-in ammatory therapy in a timely manner. From a practical point of view, it is important to recognize cardiorespiratory symptoms in time as a non-speci c manifestation of the long-term COVID-19 syndrome and the manifestation of cardiovascular pathology.

Key words: COVID-19, SARS-CoV-2, «long covid», subacute thyroiditis, glucocorticoids.

For reference: Ivanova LA, Kovalenko YS, Korol IV, et al. A clinical case of «long-covid» with damage to the endocrine, cardiovascular and pulmonary systems. The Bulletin of Contemporary Clinical Medicine. 2023; 16(2): 102-107. DOI: 10.20969/VSKM.2023.16(2).102-107.

References

  1. Коваленко Ю.С., Иванова Л.А., Король И.В., Бижева Т.В. Сахарный диабет и COVID-19. Особенности взаимного влияния двух пандемий // Вестник современной клинической медицины. – 2021. – Т. 14, вып. 4. – С.58–66. [Kovalenko YuS, Ivanova LA, Korol` IV, Bizheva TV. Saxarny`j diabet i COVID-19. Osobennosti vzaimnogo vliyaniya dvux pandemij [Diabetes mellitus and COVID-19. Features of the mutual in uence of two pandemics]. Vestnik sovremennoj klinicheskoj mediciny` [The Bulletin of Contemporary Clinical Medicine]. 2021; 14 (4): 58–66. (In Russ.)]. DOI: 10.20969/VSKM.2021.14(4).58-66

  2. Авдеев С.Н., Адамян Л.В., Алексеева Е.И., и др. Временные методические рекомендации по профилактике, диагностике и лечению новой коронавирусной инфекции (COVID-19). Версия 13 (14.10.21) // М-во здравоохранения Российской Федерации. – Москва: ГЭОТАР-Медиа, 2021. – 237 с. [Avdeev SN, Adamyan LV, Alekseeva EI, et al. Vremennye metodicheskie rekomendacii po pro laktike, diagnostike i lecheniyu novoj koronavirusnoj infekcii (COVID-19); Versiya 13 (14.10.21) [Interim guidelines for the prevention, diagnosis and treatment of novel coronavirus disease (COVID-19); Version 13 (14.10.21)]. Moskva: GeotarMedia [Moscow: Geotar-Media]. 2021; 237 p. (In Russ.)].

  3. Garg MK, Gopalakrishnan M, Yadav P, Misra S. Endocrine Involvement in COVID-19: Mechanisms, Clinical Features, and Implications for Care. Indian J Endocrinol Metab. 2020; Sep-Oct 24 (5): 381-386. DOI: 10.4103/ijem.IJEM_440_20

  4. Brancatella A, Ricci D, Viola N, et al. Subacute Thyroiditis After Sars-COV-2 Infection. J Clin Endocrinol Metab. 2020; 105 (7): 276. DOI: 10.1210/clinem/dgaa276

  5. Stasiak M, Lewiński A. New aspects in the pathogenesis and management of subacute thyroiditis. Rev Endocr Metab Disord. 2021; 22 (4): 1027-1039. DOI: 10.1007/ s11154-021-09648-y

  6. Yelin D, Wirtheim E, Vetter P, et al. Long-term consequences of COVID-19: research needs. Lancet Infect Dis. 2020; Oct 20(10): 1115-1117. DOI: 10.1016/ S1473-3099(20)30701-5

  7. Sykes DL, Holdsworth L, Jawad N, et al. Post-COVID-19 Symptom Burden: What is Long-COVID and How Should We Manage It? Lung. 2021; 199 (2): 113-119. DOI: 10.1007/s00408-021-00423-z

  8. Rowley A.H. Understanding SARS-CoV-2-related multisystem in ammatory syndrome in children. Nat. Rev. Immunol. 2020; 20: 453–454. https://doi. org/10.1038/s41577-020-0367-5

  9. Дедов И.И., Мельниченко Г.А. Эндокринология: национальное руководство // Москва: ГЭОТАР-Медиа, 2021. – 1112 с. [Dedov II, Mel’nichenko GA. Endokrinologiya: nacional’noe rukovodstvo [Endocrinology: national guidelines]. Moskva: GEOTAR-Media [Moscow: GEOTAR-Media]. 2018; 800 p. (In Russ.)].

  10. Ghantous E, Szekely Y, Lichter Y, et al. Pericardial Involvement in Patients Hospitalized With COVID-19: Prevalence, Associates, and Clinical Implications. J Am Heart Assoc. 2022; 11 (7): 024363. DOI: 10.1161/ JAHA.121.024363

 

CLINICAL CASE

UDC: 616.216.2

DOI: 10.20969/VSKM.2023.16(2).108-112

PDF download CLINICAL CASE OF JUVENILE OSSIFYING FIBROMA (JOF) MIMICKING FRONTAL SINUS MUCOCELE

ZELEVA OLESYA V., ORCID ID: 0000-0003-0143-4655; the Head of the Otorhinolaryngological Department, Samara State Medical University, Samara, Russia, 443099, st. Chapaevskaya, 89, e-mail: olesyalorik@gmail.com

ZELTER PAVEL M., ORCID ID: 0000-0003-1346-5942; C. Med. Sci, Assistant Professor of the Department of Radiation Diagnostics and Radiation Therapy, Samara State Medical University, Samara, Russia, 443099, st. Chapaevskaya, 89, e-mail: pzelter@mail.ru

KOLSANOV ALEKSANDR V., ORCID ID: 0000-0002-4144-7090; Rector of Samara State Medical University, the Head of the Department of Operative Surgery and Clinical Anatomy with a Course of Innovative Technologies, Professor of the Russian Academy of Sciences, D. Med. Sci., Professor, Samara State Medical University, Samara, Russia, 443099, st. Chapaevskaya, 89, e-mail: avkolsanov@mail.ru

SIDOROV EGOR A., ORCID ID: 0000-0002-2850-8768; Radiologist, Assistant Professor of the Department of Radiation Diagnostics and Radiation Therapy, Samara State Medical University, Samara, Russia, 443099, st. Chapaevskaya, 89, e-mail: egors9494@yandex.ru

TSOI ALEXANDER V., ORCID ID: 0000-0002-6746-5625; Otorhinolaryngologist, Samara State Medical University, Samara, Russia, 443099, st. Chapaevskaya, 89, e-mail: friend.003@mail.ru

IVANOVA OLGA V., ORCID ID: 0000-0003-4524-2671; the Head of the Pathoanatomical Department, Pathologist, C. Med. Sci., Samara State Medical University, Samara, Russia, 443099, st. Chapaevskaya, 89, e-mail: o.v.ivanova@ samsmu.ru

Abstract. Introduction. Di erential diagnosis of neoplasms of the paranasal sinuses does not lose its relevance. Benign formations of the nasal cavity and paranasal sinuses at the beginning of their formation have an asymptomatic course, as well as not always speci c signs in diagnostic studies. Computed tomography monitoring of the patient’s condition indicates a favorable prognosis for this patient. Aim. TTo present our own clinical observation of the successful diagnosis and treatment of juvenile ossifying broma imitating the mucocele of the frontal sinus. Material and Methods.Patient F., 20 years old, complains of swelling of the upper and lower eyelids of the left eye, a pulsation and pain in the left brow area, discomfort in the projection of the left maxillary sinus, di culty in breathing. Conducted general clinical, laboratory and instrumental research methods. The article details the history of the disease, clinical manifestations, the results of the examination with pathomorphological examination, conservative and surgical treatment with a description of the operation. Results and discussion. The operation was successful. The patient was discharged on the seventh day after surgery with a clinical diagnosis of juvenile ossifying broma. The control CT scan of the paranasal sinuses was performed after 6 months, the content in the left frontal sinus was not determined. Conclusion. TThese data are necessary for practitioners when conducting di erential diagnosis, because only the data of the intraoperative picture and the histological veri cation made it possible to make the correct diagnosis.

Key words: benign neoplasms of the paranasal sinuses, broma, mucocele, paranasal sinuses.

For reference: Zeleva OV, Zelter PM, Kolsanov AV, et al. Clinical observation of juvenile ossifying broma imitating the mucocele of the frontal sinus. The Bulletin of Contemporary Clinical Medicine. 2023; 16(2): 108-112.
DOI: 10.20969/VSKM.2023.16(2).108-112.

References

1. Lund VJ, Clarke PM, Swift AC, et al. Nose and paranasal sinus tumours: United Kingdom National Multidisciplinary Guidelines. J Laryngol Otol. 2016 May;130(S2): S111-S118. DOI: 10.1017/S0022215116000530. PMID: 27841122; PMCID: PMC4873911

2. Saito K, Fukuta K, Takahashi M, et al. Benign broosseous lesions involving the skull base, paranasal sinuses, and nasal cavity. Report of two cases. J Neurosurg. 1998 Jun;88(6):1116-9. DOI: 10.3171/jns.1998.88.6.1116. PMID: 9609311

3. Mikals SJ, McCuiston AM, Ramanathan M. Unilateral Nasal Obstruction. JAMA Otolaryngol Head Neck Surg. 2018;144(1):80–81. DOI:10.1001/jamaoto.2017.1801

4. Kwon Y, Shin D, Kim J, et al. Juvenile psammomatoid ossifying broma of the maxilla. Arch Craniofac Surg. 2020 Jun;21(3):193-197. DOI: 10.7181/acfs.2020.00108

5. Peterson BR, Nelson BL. Juvenile Active Ossifying Fibroma. Head Neck Pathol. 2015 Sep;9(3):384-6. DOI: 10.1007/s12105-014-0595-8

6. Sally Nguyen, Marc-André Hamel, Jade Chénard-Roy, et al. Juvenile psammomatoid ossifying broma: A radiolucent lesion to suspect preoperatively, Radiology Case Reports, Volume 14, Issue 8, 2019, Pages 1014-1020, ISSN 1930-0433, DOI: 10.1016/j.radcr.2019.05.017

7. Barth H, Maune S, E. Schluter E, et al. Benign bro-osseous tumors of the frontal skull base with intracranial extension. Report of 2 cases. Hno, 52 (2) (2004), pp. 140-144 DOI: 10.1007/s00106-003-0860-8

8. Yilmaz I, Bal N, Ozluoglu LN. Isolated cementoossif ying f ibroma of the ethmoid bulla: a case report. Ear Nose Throat J 2006; 85:322–324 DOI: 10.1177/014556130608500512

9. Грачев Н.С., Костоусова А.И., Ворожцов И.Н., и др. Ювенильная оссифицирующая фиброма синоназальной области. Российская ринология. – 2020. – Т. 28. – No 2. – С. 65-72. [Grachev NS, Kostousova AI, Vorozhcov IN. Yuvenil’naya ossi ciruyushchaya broma sinonazal’noj oblasti [Juvenile ossifying broma of the sinonasal region]. Rossijskaya rinologiya [Russian rhinology]. 2020; 28(2): 65-72. (In Russ.)]. DOI: 10.17116/rosrino20202802165

10. Горожанина А.И., Грачев Н.С., Рогожин Д.В., и др. Диагностика и хирургическая тактика при ювенильной оссифицирующей фиброме: обзор литературы. Head and Neck / Голова и шея // Российское издание. Журнал Общероссийской общественной организации Федерация специалистов по лечению заболеваний головы и шеи. 2021. Т. 9. No 3. С. 96-105. [Gorozhanina AI, Grachev NS, Rogozhin DV. Diagnostika i hirurgicheskaya taktika pri yuvenil’noj ossi ciruyushchej brome: obzor literatury [Diagnosis and surgical tactics in juvenile ossifying broma: literature review]. Golova i sheya. Rossijskoe izdanie. Zhurnal Obshcherossijskoj obshchestvennoj organizacii Federaciya specialistov po lecheniyu zabolevanij golovy i shei. [Head and Neck. Russian edition. Journal of the All-Russian Public Organization Federation of Specialists in the Treatment of Head and Neck Diseases]. 2021; 9 (3): 96-105. (In Russ.)]. DOI: 10.25792/HN.2021.9.3.96–105

 

HEALTHCARE ORGANIZATION

UDC 616-01+614.881

DOI: 10.20969/VSKM.2023.16(2).113-119

PDF download THE PROCEDURE FOR COOPERATION OF THE CENTER FOR DISASTER MEDICINE WITH MEDICAL ORGANIZATIONS IN EMERGENCY SITUATIONS

KUBASOV ROMAN V., ORCID ID: 0000-0003-1698-6479; Cand. Biol. Sci., Associate Professor of the Department of Mobilization Training of Healthcare and Disaster Medicine, Northern State Medical University, 163000, Russia, Arkhangelsk, Troitskiy Ave., 51; e-mail: romanas2001@gmail.com

SOKOLNIKOV VASILY A., ORCID ID: 0000-0002-2886-0497; Head of the Center for Disaster Medicine of "Arkhangelsk Regional Clinical Ambulance Station", 163000, Russia, Arkhangelsk, Dzerzhinsky Ave., 14; e-mail: v_sokolnikovv@mail.ru

MARTYNOV VLADISLAV O., ORCID ID: 0000-0003-1374-5928; student of the Northern State Medical University, 163000, Russia, Arkhangelsk, Troitskiy Ave., 51; e-mail: mr.vlad29rus@gmail.com

SMYKOVSKAYA ADELINA I., ORCID ID: 0000-0001-8140-328X; student of the Northern State Medical University, 163000, Russia, Arkhangelsk, Troitskiy Ave., 51; e-mail: adel.smykovskaya@gmail.com

KRYMOVA EKATERINA S., ORCID ID: 0000-0003-3036-5273; student of the Northern State Medical University, 163000, Russia, Arkhangelsk, Troitskiy Ave., 51; e-mail: Katerina_kiselev@list.ru

MENSHUTIN IGOR Y., ORCID ID: 0000-0001-8058-8593; Candidate of Medical Sciences, Senior Lecturer of the Department of Mobilization Training of Healthcare and Disaster Medicine, Northern State Medical University, 163000, Russia, Arkhangelsk, Troitskiy Ave., 51; Chief Physician of the Arkhangelsk Region State Medical Institution "Arkhangelsk City Clinical Hospital No. 4", 163000, Russia, Arkhangelsk, Dachnaya str., 30; e-mail: mensh80@mail.ru

KALININ ALEXEY G., ORCID ID: 0000-0002-0425-6359; Doctor of Medical Sciences, Professor of the Institute of Public Health, Healthcare and Social Work of the Northern State Medical University, 163000, Russia, Arkhangelsk, Troitskiy Ave., 51; e-mail: aleksei.kalinin1959@mail.ru

SANNIKOV ANATOLY L. ORCID ID: 0000-0003-0405-659X; Doctor of Medical Sciences, Professor of the Institute of Public Health, Healthcare and Social Work of the Northern State Medical University, 163000, Russia, Arkhangelsk, Troitskiy Ave., 51; e-mail: jsannikov@yandex.ru

KUBASOVA ELENA D., ORCID ID: 0000-0001-9683-7814; cand. Biol. sciences, Dean of the Faculty of Pharmacy, Associate Professor of the Department of Pharmacology and Pharmacy, Northern State Medical University, 163000, Russia, Arkhangelsk, Troitskiy Ave., 51; e-mail: lapkino@mail.ru

Abstract. Introduction. Each emergency situation is characterized by signi cant health consequences. Solving the issue of saving lives, providing medical care and keeping the health of victims is one of the most important tasks. For the timely and successful supply of emergency medical care, there is a need to create special schemes for the cooperation of medical organizations. Aim. estimation of the system of interrelation of the Arkhangelsk Regional Disaster Medicine Center with medical organizations to provide emergency medical aid to victims in emergency situations. Material and methods. Normative legal documents regulating the work of the Arkhangelsk Disaster Medicine Center were used for the study. The source of the information was the o cial websites of the Ministry of Health of the Arkhangelsk region, the Arkhangelsk Regional Clinical Ambulance Station. Results and discussion. In case of an emergency in the region, the main volume of medical evacuation measures and emergency medical care is organized by the Disaster Medicine system. Since 2019, this function has been performed by the Disaster Medicine Center of the Arkhangelsk Regional Clinical Ambulance Station. Intradepartmental and interdepartmental cooperation is strictly regulated by the relevant normative documents. Information about the su ered is sent to the operational dispatch department of the Disaster Medicine Center. At the same time, all information is transferred to the Federal Disaster Medicine Center. A medical organization is required to report about su ered to the Disaster medicine center every day. Also, the functionality of the Disaster medicine center includes the need to create a "task plan" that accumulates information about the bed pool, formations and other forces and means located in the region. Conclusion. An analysis of recent work has shown that the integration of emergency medical care stations and disaster medicine centers into one juridical entity has had a positive e ect as part of the improvement of emergency medical care. Thanks to this, the interaction schemes between the various units of the disaster medicine service have been improved. All transformations for the modernization of organizational processes conform to modern requirements and legislative needs.

Keywords: emergency situations, territorial center of disaster medicine, interaction.

For reference: Kubasov RV, Sokolnikov VA, Martynov VO, et al. The procedure for cooperation of the center for disaster medicine with medical organizations in emergency situations. The Bulletin of Contemporary Clinical Medicine. 2023; 16(2): 113-119. DOI: 10.20969/VSKM.2023.16(2).113-119.

References

1. Makin S, Ross D. Priorities of primary care in disaster medicine. BMJ Mil Health. 2022; 9: e002115. DOI: 10.1136/bmjmilitary-2022-002115

2. Sarin RR, Hick JL, Livinski AA et al. Disaster Medicine: A Comprehensive Review of the Literature From 2016. Disaster Med Public Health Prep. 2019; 13(5-6): 946-957. DOI: 10.1017/dmp.2019.18

3. Scott LA. Disaster Medicine in the Post-9/11 Era. South Med J. 2017; 110(8): 492-493. DOI: 10.14423/ SMJ.0000000000000675

4. Карпенко И.В. Всероссийская служба медицины катастроф: немного истории // Медицинская сестра. – 2012. – No 4. – С. 3-5. [Karpenko IV. Vserossijskaya sluzhba mediciny katastrof: nemnogo istorii [Russian disaster medicine service: historical aspects]. Medicinskaya sestra [The Nurse]. 2012; 4: 3-5. (In Rus.)].

5. Федоров В.Д. К истории создания службы медицины катастроф в России // Медицина катастроф. –2010.–Т.70.–No2.–С.4-6.[FyodorovVD.K istorii sozdaniya sluzhby mediciny katastrof v Rossii. [History of creation of disaster medicine service in Russia]. Medicina katastrof [Disaster Medicine]. 2019; 3: 5–11 (In Rus.)].

6. Binns C, Low WY. Fukushima Disaster. Asia Pac J Public Health. 2017; 29(2_suppl): 5S-6S. DOI: 10.1177/1010539517697598

7. Tin D, Hart A, Ciottone GR. Rethinking disaster vulnerabilities. Am J Emerg Med. 2021; 45: 660-661. DOI: 10.1016/j.ajem.2020.10.073

8. Khan F, Amatya B, Lee SY, Vasudevan V. Rehabilitation in Disaster Relief. Phys Med Rehabil Clin N Am. 2019; 30(4): 723-747. DOI: 10.1016/j.pmr.2019.06.001

9. Перегудов Н.А., Фалалеева Л.А., Новикова Е.В. Анализ деятельности территориального центра медицины катастроф по Смоленску и Смоленской области за 2017-2018 год (Обзор литературы) // Смоленский медицинский альманах. – 2019. – No 1. – С. 219-222. [Peregudov NA, Falaleeva LA, Novikova EV. Analiz deyatel'nosti territorial'nogo centra mediciny katastrof po Smolensku i Smolenskoj oblasti za 2017-2018 god (Obzor literatury) [Analysis of the activity of the territorial center of medicine of disasters in the Smolensk and the Smolensk region in 2017-2018]. Smolenskij medicinskij al'manah [Smolensk Medical Almanac]. 2019; 1: 219-222. (In Rus.)].

10. Jia H, Chen F, Du E. Adaptation to Disaster Risk- An Overview. Int J Environ Res Public Health. 2021; 18(21): 11187. DOI: 10.3390/ijerph182111187

11. Архангельский Д.А., Закревский Ю.Н., Рыбников В.Ю. Медицинская эвакуация больных (пострадавших) в арктической зоне нештатными формированиями службы медицины катастроф Северного флота России // Медико-биологические и социально-психологические проблемы безопасности в чрезвычайных ситуациях. – 2018. – No. 4. – С. 27-33. DOI 10.25016/2541-7487-2018-0-4-27-33 [Arkhangel’skiy DA, Zakrevskiy YuN, Rybnikov VYu. Medicinskaya evakuaciya bol'nyh (postradavshih) v arkticheskoj zone neshtatnymi formirovaniyami sluzhby mediciny katastrof Severnogo flota Rossii [Medical evacuation of patients (injured) in the Arctic zone by nonstaff units of the Disaster Medicine Service of the Northern Fleet of Russia]. Mediko-biologicheskie i social'no-psihologicheskie problemy bezopasnosti v chrezvychajnyh situaciyah [Medicо-Biological and Socio-Psychological Problems of Safety in Emergency Situations]. 2018;4: 27–33. (In Rus.)]. DOI 10.25016/2541-7487-2018-0-4-27-33

  1. Гончаров С.Ф., Быстров М.В., Баранова Н.Н. и др. Мобильные медицинские формирования службы медицины катастроф Министерства здравоохранения Российской Федерации // Медицина катастроф. – 2019. – Т. 107. – No 3. – С. 5-11. DOI: 10.33266/2070-1004-2019-3-5-11 [Goncharov SF, Bystrov MV, Baranova NN et al. Mobil'nye medicinskie formirovaniya sluzhby mediciny katastrof Ministerstva zdravoohraneniya Rossijskoj Federacii [Mobile Medical Formations of Service for Disaster Medicine of Ministry of Health of Russian Federation]. Medicina katastrof [Disaster Medicine]. 2019; 3: 5–11 (In Rus.)]. DOI: 10.33266/2070-1004-2019-3-5-11

  2. Crow DA, Albright EA, Koebele E. The role of coalitions in disaster policymaking. Disasters. 2021; 45. – No 1: 19-45. DOI: 10.1111/disa.12396

  3. Betka AA, Bergren MD, Rowen JL. Improving rural disaster response preparedness. Public Health Nurs. 2021; 38(5): 856-861. DOI: 10.1111/phn.12924

  4. Glow SD, Colucci VJ, Allington DR et al. Managing multiple-casualty incidents: a rural medical preparedness training assessment. Prehosp Disaster Med. 2013; 28(4): 334-341. DOI: 10.1017/ S1049023X13000423

  5. Баранов А.В., Моршнев В.А., Петчин И.В. и др. Анализ учебной деятельности Территориального центра медицины катастроф Архангельской области // Вестник Российской военно-медицинской академии. – 2017. – No 1. – С. 185-188. [Baranov AV, Morshnev VA, Petchin IV et al. Analiz uchebnoj deyatel'nosti Territorial'nogo centra mediciny katastrof Arhangel'skoj oblasti [Analysis of educational activity of territorial center of disaster medicine in Arkhangelsk region]. Vestnik Rossijskoj voenno-medicinskoj akademii [Bulletin of the Russian Military Medical Academy]. 2017; 1: 185-188 (In Rus.)].

  6. Федотов С.А., Потапов В.И., Закиров Р.Р. и др. Основные направления совершенствования деятельности территориальной Службы медицины катастроф г. Москвы // Медицинский алфавит.–2018.–Т.9.–No1.–С.5-7.[FedotovSF, Potapov VI, Zakirov RR et al. Osnovnye napravleniya sovershenstvovaniya deyatel'nosti territorial'noj Sluzhby mediciny katastrof g. Moskvy [Main directions of improving activities of territorial Moscow Disaster Medicine Service]. Medicinskij alfavit [Medical alphabet]. 2018; 9(1): 5-7. (In Rus.)].

18. Кобыляцкая И.А., Шкатова Е.Ю., Мохова Л.Я. и др. Актуальные вопросы работы специальных служб по ликвидации последствий чрезвычайных ситуаций в зарубежных странах // Вестник современной клинической медицины. – 2019. – Т. 12. – No 4. – С. 59–63. DOI: 10.20969/VSKM.2019.12(4).59-63. [Kobylyatskaya IA, Shkatova EY, Mokhova LYа, et al. Aktual'nye voprosy raboty special'nyh sluzhb po likvidacii posledstvij chrezvychajnyh situacij v zarubezhnyh stranah [Current issues of special emergency service operation in foreign countries]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Contemporary Clinical Medicine]. 2019; 12(4): 59-63. (In Rus.)]. DOI: 10.20969/ VSKM.2019.12(4).59-63

19. Kirsch TD, Lee CJ, Kimball MM, et al. Opportunities to Strengthen the National Disaster Medical System: The Military–Civilian NDMS Interoperability Study. Health security. 2022; 20(4): 339-347. DOI: 10.1089/ hs.2021.0221

20. Melnychuk E, Sallade TD, Kraus CK. Hospitals as disaster victims: Lessons not learned? J Am Coll Emerg Physicians Open. 2022; 3(1): e12632. DOI: 10.1002/emp2.12632

21. Djalali A, Della Corte F, Foletti M et al. Art of disaster preparedness in European union: a survey on the health systems. PLoS Curr. 2014; 6. DOI: 10.1371/ currents.dis.56cf1c5c1b0deae1595a48e294685d2f

22. Hecker N., Domres B. D. The German emergency and disaster medicine and management system—history and present. Chinese journal of traumatology. 2018; 21(2): 64-72. DOI: 10.1016/j.cjtee.2017.09.003

23. Kippnich M, Kowalzik B, Cermak R et al. Disaster Control and Civil Protection in Germany. Anasthesiol Intensivmed Notfallmed Schmerzther. 2017; 52(9): 606-617. DOI: 10.1055/s-0042-120231

24. Chinese Society of Disaster Medicine Chinese Medical Association et al. Blue book of disaster prevention and emergency in Chinese alliance. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2018; 30(6): 515-517. DOI: 10.3760/cma.j.issn.2095-4352.2018.06.00

25. Hou S, Lv Q, Ding H, et al. Disaster medicine in China: present and future. Disaster medicine and public health preparedness. 2018; 12(2). 157-165. DOI: 10.1017/dmp.2016.71

26. Агапитов А.А., Бойков А.А. Силы и средства службы медицины катастроф Санкт-Петербурга // Медико-биологические и социально-психологические проблемы безопасности в чрезвычайных ситуациях. – 2016. – No 4. – С. 21-30. [Agapitov AA, Boikov AA. Sily i sredstva sluzhby mediciny katastrof SanktPeterburga [Forces and assets of disaster medicine service of St. Petersburg]. Mediko-biologicheskie i social'no-psihologicheskie problemy bezopasnosti v chrezvychajnyh situaciyah [Medical-Biological and Sociopsychological Problems of Safety in Emergency Situations]. 2016; 4: 21–30 (In Rus.)].

27. Лемешкин Р.Н., Гуменюк В.И., Гуменюк О.В. и др. Проблемные вопросы организации взаимодействия медицинских сил и средств различных министерств и ведомств в Единой государственной системе предупреждения и ликвидации чрезвычайных ситуаций // Вестник Российской военно-медицинской академии. – 2016. – No 1. – С. 176-183. [Lemeshkin RN, Gumenyuk VI, Gumenyuk OV Problemnye voprosy organizacii vzaimodejstviya medicinskih sil i sredstv razlichnyh ministerstv i vedomstv v Edinoj gosudarstvennoj sisteme preduprezhdeniya i likvidacii chrezvychajnyh situacij [Problematic issues of organization of interaction of medical forces and means of various ministries and departments in uniform state system of the prevention and elimination of emergency situations]. Vestnik Rossijskoj voenno-medicinskoj akademii [Bulletin of the Russian Military Medical Academy]. 2016; 1: 176-183. (In Rus.)].

28. Быстров М.В. Анализ организационных моделей функционирования службы медицины катастроф Министерства здравоохранения Российской Федерации на региональном уровне // Медицина катастроф. – 2021. – No 4. – С. 5-10. DOI: 10.33266/2070-1004-2021-4-5-10 [Bystrov MV. Analiz organizacionnyh modelej funkcionirovaniya sluzhby mediciny katastrof Ministerstva zdravoohraneniya Rossijskoj Federacii na regional'nom urovne [Analysis of Organizational Models of Disaster Medicine Service of the Ministry of Health of the Russian Federation at Regional Level]. Medicina katastrof [Disaster Medicine]. 2021; 4: 5-10 (In Russ.). DOI: 10.33266/2070-1004-2021-4-5-10 (In Rus.)].

29. Себелев А.И., Ярмолич В.А., Поройский С.В. и др. Оказание экстренной медицинской помощи пострадавшим в дорожно-транспортных происшествиях в Волгоградской области // Медицина катастроф. – 2019. – No 3. – С. 12-16. [Sebelev AI, Yarmolich VA, Poroysky SV, et al. Okazanie ekstrennoj medicinskoj pomoshchi postradavshim v dorozhno-transportnyh proisshestviyah v Volgogradskoj oblasti [Provision of Emergency Medical Assistance to Victims of Traffic Accidents in Volgograd Oblast]. Medicina katastrof [Disaster Medicine]. 2019; 3: 12–16 (In Rus.)]. DOI: 10.33266/2070-1004-2019-3-12-16

30. Белоусов А.И., Базанов С.В., Халезин Э.С. Организация работы региональной службы медицины катастроф ивановской области по реализации федеральной целевой программы "Повышение безопасности дорожного движения в 2006-2012 годах" // Медицина катастроф. – 2008. – Т. 62. – No 2. – С. 34-36. [Belousov AI, Bazanov SV, Khalezin ES. Organizaciya raboty regional'noj sluzhby mediciny katastrof ivanovskoj oblasti po realizacii federal'noj celevoj programmy "Povyshenie bezopasnosti dorozhnogo dvizheniya v 2006-2012 godah" [Organization of work of regional disaster medicine service of Ivanovkaya oblast in realization of federal purposeful program "Rise of traffic safety in 2006-2012"]. Medicina katastrof [Disaster Medicine]. 2008; 2 (62): 34-36. (In Rus.)].