Vol. 16 Issue 3 (2023)

VSKM 2023 N 3

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ORIGINAL RESEARCH

Relationship of type D personality and endothelial dysfunction in patients with acute myocardial infarction Galyautdinova V.R. (Russia, Ufa), Mutalova E.G. (Russia, Ufa), Nigmatullina A.E. (Russia, Ufa), Samigullina L.I.(Russia, Ufa) P.7

Comparative analysis of 9-year dynamics of cardiovascular status parameters in residents of the arctic and southern territories of the tyumen region Gorbatenko E.A. (Russia, Tomsk), Yaroslavskaya E.I. (Russia, Tomsk), Sapozhnikova A.D. (Russia, Tomsk) P.15

Etiological and clinical features of anaphilactic shock in patients hospitalized in the emergency medicine clinic Delyan V.Y. (Russia, Kazan), Sibgatullina N.A. (Russia, Kazan), Zakirova G.N. (Russia, Kazan), Akhmedzyanova D.G. (Russia, Kazan), Yunusova D.F. (Russia, Kazan) P.24

Somatic mutations in patients with leukoplakia of the oral mucosa Karpuk N.A. (Republic of Belarus, Vitebsk), Rubnikovich S.P (Republic of Belarus, Minsk), Zhyltsou I.V. (Republic of Belarus, Vitebsk), Mazur O.C. (Republic of Belarus, Minsk), Karpuk I.Yu. (Republic of Belarus, Vitebsk), Mikhalenka A.P.(Republic of Belarus, Minsk) P.30

Stabilization of indicators of the cardiological status of patients with COVID19 with the use of ehf therapy Kashtanova N.M. (Russia, Kazan), Zhivotova E.N. (Russia, Kazan), Suchkova G.G. (Russia, Kazan), Druzhinin G.A. (Russia, Kazan), Oranskaya T.I. (Russia, Kazan), Valiullin V.V. (Russia, Kazan), Khairullin A.E. (Russia, Kazan) P.37

Application of autological microfragmented adipose tissue in the treatment of postradiation ulcerative proctitis Leontiev A.V. (Russia, Moscow), Grishina E.A. (Russia, Moscow), Danilov M.A. (Russia, Moscow), Karnaukhov N.S. (Russia, Moscow), Shishin K.V. (Russia, Moscow) P.42

A modern sociosomatic portrait of a woman with pathological climax Mardieva R.R. (Russia, Kazan), Mazitova M.I. (Russia, Kazan), Mazitov D.A. (Russia, Kazan), Faustova K.V. (Russia, Kazan), Garafieva S.M. (Great Britain) P.48

Assessment of the predictive capability of artificial intelligence methods in the prediction of cardiovascular events Nevzorova V.A. (Russia, Vladivostok), Plekhova N.G. (Russia, Vladivostok), Chernenko I.N. (Russia, Vladivostok), Priseko L.G. (Russia, Vladivostok), Menovshchikova A.K. (Russia, Vladivostok) P.54

Oxidative stress severity in patients with myocardial infarction and copd Prokofyeva T.V. (Russia, Astrakhan), Polunina O.S. (Russia, Astrakhan) P.62

The assessment of the relationship significance between vascular remodeling, inflammatory response and polymorphism of endothelial dysfunction genes in male patients with myocardial infarction due to hypertention history Sadikova R.I. (Russia, Ufa), Mutalova E.G. (Russia, Ufa), Frid S.A. (Russia, Ufa), Nigmatullina A.E. (Russia, Ufa) P.68

Comprehensive assessment of clinicalsyndromic and socio-psychological characteristics of patients with somatoform disorders and working in the nuclear industry Sineutskaya E.O. (Russia, Moscow), Petrov D.S. (Russia, Ryazan), Volodin B.Y. (Russia, Ryazan), Shulaev A.V. (Russia, Kazan), Konovalov O.E. (Russia, Moscow) P.77

Pathomorphological changes of the upper respiratory tract in patients suffering from snoring and obstructive sleep apnea syndrom Starkova L.N. (Russia, Ryazan), Pichtileva N.A. (Russia, Ryazan) P.84

REVIEWS

The impact of genetic and epigenetic factors on the development of arterial hypertension Sadykova A.R. (Russia, Kazan), Pilipchuk S.A. (Russia, Kazan), Shaidullina D.M. (Russia, Kazan), Makarov M.A. (Russia, Kazan), Khabiboullina R.T. (Russia, Kazan), Kozlova A.M. (Russia, Kazan) P.90

Evolution of understanding the role of chronic inflammation as a key element in asthma pathogenesis Khakimova M.R. (Russia, Kazan) P.97

CLINICAL CASE

Large left ventricular fibroma in a child Volgina S.Y. (Russia, Kazan), Sagdiev D. A. (Russia, Kazan), Nikolaev D.A. (Russia, Kazan), Solovieva N.A. (Russia, Kazan), Kulakova G.A. (Russia, Kazan), Kurmaeva E.A. (Russia, Kazan) P.106

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ORIGINAL RESEARCH

UDC 616.127-005.8

DOI: 10.20969/VSKM.2023.16(3).7-14

PDF download RELATIONSHIP OF TYPE D PERSONALITY AND ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

GALYAUTDINOVA VELENA R., ORCID ID: 0000-0001-9715-6930; Assistant professor of the Department of advanced internal medicine No 1, Bashkir State Medical University, Russia, 450000, Ufa, Lenin str., 3, tel. 8-347-272-41-73, e-mail: velena.galyautdinova1704@gmail.com

MUTALOVA ELVIRA G., ORCID ID: 0000-0002-7454-9819; D. Med. Sci., professor, the Head of the Department of advanced internal medicine No 1, Bashkir State Medical University, Russia, 450000, Ufa, Lenin str., 3, tel. 8-347-272-41-73, e-mail: emutalova@mail.ru

NIGMATULLINA ALBINA E., ORCID ID: 0000-0002-3511-8477; C. Med. Sci., associate professor of the Department of advanced internal medicine No 1, Bashkir State Medical University, Russia, 450000, Ufa, Lenin str., 3, tel. 8-347-272-41-73, e-mail: e-mail: albanigma@mail.ru

SAMIGULLINA LIANA I., ORCID ID: 0000-0003-1876-7325; C. Med. Sci., associate professor of the Department of advanced internal medicine No 1, Bashkir State Medical University, Russia, 450000, Ufa, Lenin str., 3, tel. 8-347-272-41-73, e-mail:liana_sam@inbox.ru

Abstract. Introduction. Major psychosocial risk factors for acute myocardial infarction include depression, anxiety (various anxiety syndromes and disorders), pessimistic D personality type, work and family stress, anger/hostility, lack of social support, and low socioeconomic status. There are few studies evaluating the association between psychological factors and myocardial infarction. Aim. The aim of the study was to study the relationship of personality type D with the development of endothelial dysfunction in patients with acute myocardial infarction. Material and methods. The study included 158 patients, mean age 58.2±2.5 years, who were admitted to the hospital for ST-segment elevation myocardial infarction. The diagnosis was established according to the clinical guidelines of the Russian Society of Cardiology, 2020. In addition to the traditional clinical and instrumental examination, on the 3rd–7th day after the development of myocardial infarction, patients underwent an assessment of plasma concentrations of in ammatory biomarkers and psychological testing using anxiety and depression rating scales. In the group of patients, individuals with and without personality type D were identi ed. Results and discussion. Personality type D was found in 29.1% of patients with acute myocardial infarction. Patients with personality type D were signi cantly younger, employed and married, had a higher body mass index and a signi cantly greater hereditary burden of arterial hypertension. In patients with personality type D, the values of pro-in ammatory markers were statistically signi cantly di erent from the comparison group, which indicates the intensity of subclinical in ammation and cytokine imbalance. Personality type D was signi cantly associated with total in ammation score and total endothelial dysfunction score. Signi cant di erences were found in the ratio of patients with depressive conditions in subgroups of patients with personality type D. The values of echocardiographic parameters were also associated with the presence of personality type D. Conclusion.Personality type D was associated with impaired endothelial function in men with acute myocardial infarction, they were more likely to have depressive disorders. An adverse e ect of personality type D on the cardiovascular system in patients with myocardial infarction was revealed.

Key words: personality type D, myocardial infarction, depression, endothelial dysfunction, in ammation.

For reference: Galyautdinova VR, Mutalova EG, Nigmatullina AE, Samigullina LI. Relationship of type D personality and endothelial dysfunction in patients with acute myocardial infarction. The Bulletin of Contemporary Clinical Medicine. 2023; 16(3): 7-14. DOI: 10.20969/VSKM.2023.16(3).7-14.

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UDC: 612.176.2:57.045

DOI: 10.20969/VSKM.2023.16(3).15-23

PDF download COMPARATIVE ANALYSIS OF 9-YEAR DYNAMICS OF CARDIOVASCULAR STATUS PARAMETERS IN RESIDENTS OF THE ARCTIC AND SOUTHERN TERRITORIES OF THE TYUMEN REGION

GORBATENKO ELENA A., ORCID ID: 0000-0003-3675-1503, Scopus Author ID: 14045151200, Researcher ID: M-8298-2019, RSCI Author ID: 568636, Junior Scienti c Researcher, Laboratory of Instrumental Diagnostics, Scienti c Department of Instrumental Research Methods, Tyumen Cardiology Research Center, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia, 625033, Tyumen, Melnikayte str., 111, e-mail: еlena@infarkta.net

YAROSLAVSKAYA ELENA I., ORCID ID: 0000-0003-1436-8853, Scopus Author ID: 36459379400, Researcher ID: C-6778-2016, RSCI Author ID: 644593, Doctor of Medical Sciences, Professor, Doctor of Ultrasound Diagnostics, Head and Leading Scienti c Researcher of the Laboratory of Instrumental Diagnostics, Scienti c Department of Instrumental Research Methods, Tyumen Cardiology Research Center, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia, 625033, Tyumen, Melnikayte str., 111, e-mail: Yaroslavskaya@infarkta.net, yaroslavskayae@gmail.com

SAPOZHNIKOVA ANASTASIA D., ORCID ID: 0000-0003-0961-2348, Scopus Author ID: 57208473755, Researcher ID: G-7090-2019, RSCI Author ID: 1074487, Researcher, Laboratory of Instrumental Diagnostics, Scienti c Department of Instrumental Research Methods, Tyumen Cardiology Research Center, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia, 625033, Tyumen, Melnikayte str., 111, e-mail: SapozhnikovaAD@ infarkta.net

Abstract. Introduction. Studies show that coronary atherosclerosis and coronary artery disease in the Arctic and Subarctic regions have their own characteristics and need to be further studied. Aim. To conduct a comparative prospective analysis of clinical, laboratory, echocardiographic and coronary angiography data in middle-aged residents of the Arctic regions compared with residents of the south of Tyumen region. Material and methods. From the Coronary Angiography Registry we selected 229 patients of mean age 45-59 years who underwent coronary angiography more than once between 2000 and 2021. The average interval between the 1st and 2nd survey points was 9.0±3.4 years. Patients who underwent coronary angiography to verify the diagnosis, patients with stable coronary artery disease and old myocardial infarction were included. Individuals with acute coronary syndrome were not included. Patients were divided into 2 groups: 85 residents of Tyumen and the south of Tyumen region and 144 residents of the Yamal-Nenets Autonomous Okrug. Di erences between groups and dynamics of the studied parameters were assessed using the application package IBM SPSS Statistics 21. Results and discussion. The groups were comparable in demographic characteristics. Initially, cardiovascular status was more severe in Yamal-Nenets Autonomous Okrug group of patients: more severe (II and III) functional classes of exertional angina and a history of myocardial infarction, hemodynamically signi cant coronary lesions, including coronary artery occlusion, were more common. In Yamal-Nenets Autonomous Okrug group, the level of high-density lipoprotein cholesterol was initially lower. During the follow-up period, obesity and echo-signs of post-infarction changes were detected in patients of Yamal-Nenets Autonomous Okrug more often, higher asynergy index and triglyceride levels were recorded. Intergroup di erences in the incidence of myocardial infarction and occlusive lesions and high-density lipoprotein cholesterol levels persisted. Conclusion. During 9-year follow-up, middle-aged patients who underwent elective coronary angiography and lived in the Arctic zone had more severe baseline indicators of cardiovascular status, as well as their more signi cant negative dynamics compared to patients lived in the south of Tyumen region.

Key words: coronary atherosclerosis, Arctic, cardiovascular diseases, coronary artery disease.

For reference: Gorbatenko EA, Yaroslavskaya EI, Sapozhnikova AD. Comparative analysis of 9-year dynamics of cardiovascular status parameters in residents of the Arctic and Southern territories of Tyumen region. The Bulletin of Contemporary Clinical Medicine. 2023; 16(3): 15-23. DOI: 10.20969/VSKM.2023.16(3).15-23.

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  9. Афтанас Л.И., Воевода М.И., Пузырев В.П., Мель-ников В.Н. Арктическая медицина в XXI веке // Здо-ровье коренного и пришлого населения Чукотского автономного округа. Новосибирск: Академическое издательство «Гео», 2018. С. 201-207. [Aftanas LI, Voevoda MI, Puzyrev VP, Melnikov VN. Arkticheskaya meditsina v XXI veke [Arctic Medicine in the 21st Century]. Zdorov’ye korennogo i prishlogo naseleniya Chukotskogo avtonomnogo okruga [Health of the Indigenous and Newcomer Population of Chukotka Autonomous Okrug]. Novosibirsk: Akademicheskoye izdatel’stvo «Geo» [Novosibirsk: Academic Publishing House «Geo»], 2018, pp. 201-207 (In Russ.)].
  10. Сергейчик О.И., Ярославская Е.И., Плюснин А.В. Влияние факторов внешней среды на риск сердеч-но-сосудистых заболеваний населения Арктики (обзор) // Журн. мед.-биол. исследований. – 2022. - Т.10, No1 - С.64-72. [Sergeychik OI, Yaroslavskaya EI, Plyusnin AV. Vliyaniye faktorov vneshney sredy na risk serdechno-sosudistykh zabolevaniy naseleniya Arktiki (obzor) [Impact of Environmental Factors on the Risk of Cardiovascular Disease in the Population of the Arctic (Review)]. Zhurnal mediko-biologicheskikh issledovaniy [Journal of Medical and Biological Research]. 2021; 10(1): 64–72 (In Russ.)]. DOI: 10.37482/2687-1491- Z091

 

UDC 612.017.3:616-02-056.43

DOI: 10.20969/VSKM.2023.16(3).24-30

PDF download ETIOLOGICAL AND CLINICAL FEATURES OF ANAPHILACTIC SHOCK IN PATIENTS HOSPITALIZED IN THE EMERGENCY MEDICINE CLINIC

DELYAN VICTORIA Y., ORCID ID: 0000-0001-6816-4253, SPIN-code: 5562-4056; Associate Professor of the Department of Allergology and Immunology of the Kazan State Medical Academy, Russia, 420012, Kazan, Butlerova st., 36, e-mail: viktoria_delyan@mail.ru

SIBGATULLINA NAILYA A., ORCID ID: 0000-0002-7879-6796; Assistant Professor of the Department of Allergology and Immunology, Kazan State Medical, Russia, 420012, Kazan, st. Butlerova, 36, e-mail: nailyasibg@mail.ru

ZAKIROVA GUZEL N., ORCID ID: 0000-0002-7980-9165; Head of the City Center of Allergology and Immunology, «City Clinical Hospital» No. 7, Russia, 320103, Kazan, st. Chuykova, 54, e-mail: zakirova.guzel@gmail.com

AKHMEDZYANOVA DAMIRA G., ORCID ID: 0000-0001-9809-0806; allergologist-immunologist of the City Center of Allergology and Immunology of the City Clinical Hospital No. 7, Russia, 320103, Kazan, st. Chuykova, 54, e-mail: ahmdamira@yandex.ru

YUNUSOVA DIANA F., ORCID ID: 0000-0002-8023-6034; resident physician, Department of Allergology and Immunology of the Kazan State Medical Academy, Russia, 420012, Kazan, st. Butlerova, 36, e-mail: yunusovadiana10@gmail.com

Abstract. Introduction. Anaphylaxis is a severe generalized hypersensitivity reaction a ecting more than one organ system that can start very quickly and symptoms can be severe or life-threatening. The pro le of triggers and cofactors for anaphylaxis is age dependent and varies across geographies. The clinical manifestations of anaphylaxis are diverse, one of its most severe clinical phenotypes is anaphylactic shock. Aim. To assess the signi cance of various groups of triggers, cofactors and clinical features of anaphylactic shock in patients hospitalized in the Department of Allergology and Immunology of the Kazan City Clinical Hospital No. 7. Material and methods. A retrospective analysis of 107 medical records of inpatients hospitalized in the Department of Allergology and Immunology of City Clinical Hospital No. 7 with a diagnosis of anaphylactic shock (T78.0, T78.2, T80.5, T88.6) was carried out for three calendar years (from 01.01.2018 to 31.12.2020). Statistical data processing was carried out using the Statistical Package for Social Sciences (v.18.0). Results and discussion. It has been shown that medicines were the most common trigger for anaphylactic shock in hospitalized patients, while food and insect bites led to the development of shock much less frequently and with approximately the same frequency. The vast majority of patients did not have concomitant diseases, and also did not take concomitant therapy, which are risk factors for the severe course of anaphylaxis. Skin changes were the most frequent symptom, supplementing the clinic of anaphylactic shock, followed, approximately with equal frequency, by gastrointestinal and respiratory symptoms, neurological symptoms were most rarely recorded. Conclusion. To verify the trigger as the cause of anaphylactic shock, it is necessary to conduct an allergological examination after the resolution of its symptoms. To assess the in uence of exogenous and endogenous cofactors on the occurrence of anaphylaxis and the severity of its course, it is necessary to conduct prospective studies.

Key words: anaphylaxis, anaphylactic shock, triggers, cofactors.

For reference: Delyan VY, Sibgatullina NA, Zakirova GN, et al. Etiological and clinical features of anaphilactic shock in patients hospitalized in the emergency medicine clinic. The Bulletin of Contemporary Clinical Medicine. 2023; 16(2): 24-30. DOI: 10.20969/VSKM.2023.16(2).24-30.

References

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IB, Asta eva NG, et al. Ana lakticheskij shok. Klinicheskie rekomendacii Rossijskoj associacii allergologov i klinicheskih immunologov i Obshcherossijskoj obshchestvennoj organizacii «Federaciya anesteziologov i reanimatologov» [Anaphylactic shock. Clinical guidelines of Russian Association of Allergists and Clinical Immunologists and the All-Russian Public Organization “Federation of Anesthesiologists and Reanimatologists”]. Vestnik intensivnoj terapii im. A.I. Saltanova [Annals of Critical Care]. 2020; 3: 15–26. (In Russ.)]. DOI: 10.21320/1818-474X-2020-3-15-26

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UDC 616.311-002.157

DOI: 10.20969/VSKM.2023.16(3).30-36

PDF download SOMATIC MUTATIONS IN PATIENTS WITH LEUKOPLAKIA OF THE ORAL MUCOSA

KARPUK NATALIA A., ORCID ID: 0000-0001-9991-7034; Associate Professor, Associate Professor of the Department of General and Orthopedic Dentistry with the course of FAT and RP Vitebsk State Medical University, 210009, Republic of Belarus, Vitebsk, Frunze Ave., 27; e-mail: ms.karpuk@mail.ru

RUBNIKOVICH SERGEY P., ORCID ID: 0000-0002-7450-3757; Corresponding Member, D. Sc. (Med.), Professor, Rector. Belarusian State Medical University, 220116, Republic of Belarus, Minsk, Dzerzhinski Ave., 83; e-mail: rubnikovichs@mail.ru

ZHYLTSOU IVAN V., ORCID ID: 0000-0002-4912-2880; D. Sc. (Med.), Professor, Head of the Department of Evidence-Based Medicine and Clinical Diagnostics of the Faculty of Advanced Training and Retraining of Vitebsk State Medical University, 210009, Republic of Belarus, Vitebsk, Frunze Ave., 27; e-mail: zhyltsou@tut.by

MAZUR OKSANA C., ORCID ID: 0000-0002-6093-4548; Researcher, Laboratory of Environmental Genetics and Biotechnology, Institute of Genetics and Cytology of the Belarusian National Academy of Sciences, 220072, Republic of Belarus, Minsk, Akademicheskaya st., 27; e-mail: terezia@mail.ru

KARPUK IVAN Yu., ORCID ID: 0000-0001-9991-7035; D. Sc. (Med.), dean of the Faculty of Dentistry, Professor of the Department of General Dentistry including the course of Prosthodontic Dentistryof. Vitebsk State Medical University, 210009, Republic of Belarus, Vitebsk, Frunze Ave., 27; e-mail: ikarpuk@mail.ru

MIKHALENKA ALENA P., ORCID ID: 0000-0003-4543-2862; PhD (Biol.), Senior Researcher, Laboratory of Environmental Genetics and Biotechnology, Institute of Genetics and Cytology of the Belarusian National Academy of Sciences, 220072, Republic of Belarus, Minsk, Akademicheskaya st., 27; e-mail: michalenko75@mail.ru

Abstract. Introduction. Genetic basis for the development of leukoplakia of the oral mucosa is not well understood. Early prediction of oral mucosa cancer development is an important public health problem, which results in the importance of studying the pathogenesis of precancerous diseases. Malignant neoplasms of oral mucosa are mainly the cases of squamous cell carcinoma which commonly develops as the outcome of previous potentially malignant diseases, the leading of which is oral mucosa leukoplakia. Aim. The goal of study is to determine pathogenic somatic mutations in patients with oral mucosa leukoplakia and grade 1 epithelial dysplasia. Material and methods. We have studied 24 samples of altered epithelium of patients with oral mucosa leukoplakia. The QIAamp DNA FFPE Tissue Kit (Qiagen, Germany) was used to isolate deoxyribonucleic acid from the samples. Sequencing was performed with Illumina NextSeq 550 sequencer and TruSightTM Oncology 500 DNA Kit (Illumina, USA). All operations for deoxyribonucleic acid extraction, sampling and sequencing were performed step by step in strict accordance with the instructions supplied with the reagent kits. Bioinformatic analysis was performed using Illumina BaseSpace and Galaxy Project software in accordance with current guidelines. Results and discussion. Pathogenic and probably pathogenic somatic mutations identi ed during this study in TP53, KRAS, APC, NRAS and BRAF genes, both singly and in combination, are reliably (risk ratios 3000-11000) associated with the development of leukoplakia of the oral mucosa with epithelial dysplasia of 1st degree. The multiplicity of genetic variants associated with epithelial dysplasia, as well as the fact that a number of variants do not occur in all patients simultaneously, suggests that the same histotype of oral mucosa dysplasia may develop under the in uence of various mutations. Conclusion. Pathogenic and probably pathogenic variants of TP53, KRAS, APC, NRAS and BRAF genes, both singly and in combinations, are reliably associated with the development of leukoplakia of the oral mucosa with epithelial dysplasia of 1st degree (risk ratios 3000-11000).

Key words: deoxyribonucleic acid sequencing, somatic mutations, leukoplakia of the oral mucosa, oral mucosa.

For reference: Karpuk NA, Rubnikovich SP, Zhyltsou IV, et al. Somatic mutations in patients with leukoplakia of the oral mucosa. The Bulletin of Contemporary Clinical Medicine. 2023; 16(3): 30-36. DOI: 10.20969/VSKM.2023.16(3).30-36.

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UDC: 616.127-005.4-073.756.8

DOI: 10.20969/VSKM.2023.16(3).37-41

PDF download STABILIZATION OF INDICATORS OF THE CARDIOLOGICAL STATUS OF PATIENTS WITH COVID-19 WITH THE USE OF EHF THERAPY

KASHTANOVA NATALIA M., ORCID ID: 0000-0001-5544-6614, C. Chem. Sci., Associate Professor of the Department of Medical and Biological Physics with Computer Science and Medical Equipment of the Kazan State Medical University, 420012, Russia, Kazan, Butlerova str., 49; e-mail: natalia.kashtanova@kazangmu.ru

ZHIVOTOVA ELENA N., ORCID ID: 0000-0003-3733-674X, C. Phys-math. Sci., Associate Professor of the Department of Medical and Biological Physics with Computer Science and Medical Equipment of the Kazan State Medical University, 420012, Russia, Kazan, Butlerova str., 49; e-mail: elzhivotova@gmail.com

SUCHKOVA GALINA G., ORCID ID: 0000-0002-8640-8546, C. Chem. Sci., Assistant Professor of the Department of Medical and Biological Physics with Computer Science and Medical Equipment of the Kazan State Medical University, 420012, Russia, Kazan, Butlerova str., 49; e-mail: galinasd@mail.ru

DRUZHININ GEORGY A., ORCID ID: 0000-0002-1086-8503, Assistant Professor of the Department of Medical and Biological Physics with Computer Science and Medical Equipment of the Kazan State Medical University, 420012, Russia, Kazan, Butlerova str., 49; e-mail: scor.druzh@mail.ru

ORANSKAYA TATIANA I., ORCID ID: 0000-0002-8408-455X, C. Biol. Sci., Associate Professor of the Department of Medical and Biological Physics with Computer Science and Medical Equipment of the Kazan State Medical University, 420012, Russia, Kazan, Butlerova str., 49; e-mail: tatiana.oranskaya@kazangmu.ru

VALIULLIN VIKTOR V., ORCID ID: 0000-0002-0299-696X, D. Biol. Sci., Professor of the Department of Histology, Cytology and Embryology of the Kazan State Medical University, 420012, Russia, Kazan, Butlerova str., 49; e-mail: valiullinvv@yandex.ru

KHAIRULLIN ADEL E., ORCID ID: 0000-0001-6155-622X, Scopus ID: 57188687928, C. Biol. Sci., Assistant Professor of the Department of Biochemistry and Clinical Laboratory Diagnostics of the Kazan State Medical University, 420012, Russia, Kazan, Butlerova str., 49, Senior Researcher of the Research Institute «Mechanobiology», Kazan (Volga Region) Federal University, 420012, Russia, Kazan, 74 Karl Marx Street; e-mail: khajrulli@yandex.ru

Abstract. Introduction. Currently, non-drug methods of correction of impaired body functions are becoming increasingly important. Especially intensive research is being conducted on biological e ects associated with the e ects of electromagnetic radiation on living organisms. Aim. The aim of the study is to study the possible facilitating e ect of extremely high-frequency therapy in recovery after physical exertion of COVID–19 patients. Material and methods.The research was conducted on volunteer students of the 1st and 2nd year of KSMU. Control groups of girls and boys were formed, as well as groups of COVID-19 patients. Extremely high-frequency radiation treatment of the C5 point on the anteromedial (inner-elbow) side of the forearm was performed, which is used in the treatment of a number of heart diseases by acupuncture. During the study, the blood pressure and heart rate of the subject were rst measured using a standard tonometer – without load (control) and after 20 squats of the subject. After that, the extremely high- frequency emitter was brought to the indicated area of the forearm, and 3–minute therapy was performed. Then the blood pressure and heart rate of the subject were measured again. Alternative series were also carried out, with measurement without extremely high-frequency treatment. The comparison of the average values of the samples was carried out on the basis of the Student’s t-test. Results and discussion. It was found that in non-COVID-19 patients, the extremely high-frequency therapy performed did not signi cantly change the parameters of blood pressure and heart rate in the groups of boys and girls. In young men who have been ill with COVID-19, there is a tendency to earlier recovery after physical exertion when using extremely high-frequency therapy. Extremely high-frequency therapy had a greater impact on girls who had had COVID-19 than on those who had not had this disease. At the same time, this group of subjects clearly has a vector for a more complete recovery after physical exertion for all the studied indicators. However, only systolic pressure was signi cantly equalized (p<0.05). Conclusion. The stabilizing e ect of extremely high-frequency therapy on systolic blood pressure values in COVID-19 girls was revealed.

Key words: EHF-therapy, COVID-19, physical rehabilitation, recovery after exercise.

For reference: Kashtanova NM, Zhivotova EN, Suchkova GG, et al. Stabilization of indicators of the cardiological status of patients with COVID-19 with use of EHF therapy. The Bulletin of Contemporary Clinical Medicine. 2023; 16(3): 37-41. DOI: 10.20969/VSKM.2023.16(3).37-41.

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UDC: 616.127-005.4-073.756.8

DOI: 10.20969/VSKM.2023.16(3).42-47

PDF download APPLICATION OF AUTOLOGICAL MICROFRAGMENTED ADIPOSE TISSUE IN THE TREATMENT OF POST-RADIATION ULCERATIVE PROCTITIS

LEONTIEV ALEXANDER V., ORCID ID: 0000-0003-3363-6841, C. Med. Sci, Coloproctologist, Coloproctology Department, Moscow Clinical Scienti c and Practical Center named after I.I. A.S. Loginov of the Moscow Healthcare Department, Russia, 111123, Moscow, highway Entuziastov 86, e-mail: a.leontev@mknc.ru

GRISHINA ELENA A., ORCID ID: 0000-0002-1265-8382, Endoscopist, Department of Operative Endoscopy, Moscow Clinical Scienti c and Practical Center named after I.I. A.S. Loginova of the Moscow Healthcare Department, Russia, 111123, Moscow, highway Entuziastov 86, e-mail: a.grishina@mknc.ru

DANILOV MIKHAIL A., ORCID ID: 0000-0001-9439-9873, C. Med. Sci, Head of the Coloproctology Department, Moscow Clinical Scienti c and Practical Center named after I.I. A.S. Loginov of the Moscow Healthcare Department, Russia, 111123, Moscow, highway Entuziastov 86, e-mail: m.danilov@mknc.ru

KARNAUKHOV NIKOLAY S., ORCID ID: 0000-0003-0889-2720, C. Med. Sci, Head of the Department of Pathology, Moscow Clinical Scienti c and Practical Center named after I.I. A.S. Loginov of the Moscow Healthcare Department, Russia, 111123, Moscow, highway Entuziastov 86, e-mail: n.karnaukhov@mknc.ru

SHISHIN KIRILL V., ORCID ID: 0000-0003-0010-5294, D. Med. Sci, Head of the Department of Endoscopy, Moscow Clinical Scienti c and Practical Center named after A.I. A.S. Loginov of the Moscow Healthcare Department, Russia, 111123, Moscow, highway Entuziastov 86, e-mail: k.shishin@mknc.ru

Abstract. Introduction. Post-radiation ulcerative proctitis is a serious complication after radiotherapy for cancer of the prostate, cervix and uterine body, anal canal, and other pelvic tumors. Given the mechanism of occurrence, there are currently no pathogenetic methods for the treatment of post-radiation ulcerative proctitis. Aim. Is to develop a technique and evaluate its e ectiveness in the treatment of patients with post-radiation rectal ulcers using autologous microfragmented adipose tissue. Material and methods. The study included 30 patients, of which 24 (80.0% were women and 6 (20.0%) were men. Manual lipoaspiration was used to obtain autologous adipose tissue. Then, microfragmentation was performed through transfers. The introduction of autologous concentrated adipose tissue was performed in edges of post-radiation ulcerative defect of the rectal wall under endoscopic control. Results and discussion. The duration of the manipulation from the moment of adipose tissue sampling to the end of the injection was a little more than an hour (Me = 75.0 min). No intraoperative complications were identi ed. One patient (3.3%) had a local recurrence of cervical cancer, and therefore the patient was excluded from the study. Control rectoscopy after 6 months in 28 (93.3%) patients showed complete epithelialization of post-radiation ulcerative defects of the rectum.Conclusion. The technique of using autologous microfragmented adipose tissue is a ordable and e ective in the treatment of patients with post-radiation ulcerative proctitis.

Key words: rectal ulcer, autologous adipose tissue, late complications of radiotherapy.

For reference: Leontiev AV, Grishina EA, Danilov MA, et al. Application of autological microfragmented adipose tissue in the treatment of post-radiation ulcerative proctitis. The Bulletin of Contemporary Clinical Medicine. 2023; 16(3): 42- 47. DOI: 10.20969/VSKM.2023.16(3).42-47.

References

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  2. Dahiya DS, Kichloo A, Tuma F, Albosta M, Wani F. Radiation Proctitis and Management Strategies. Clin Endosc. 2022;55: 22-32. DOI: 10.5946/ce.2020.288

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  5. Терюшкова Ж. И. Новые технологии в лечении пост-лучевых повреждений прямой кишки: специальность 3.1.9 «Хирургия». Автореферат диссертации на со-искание ученой степени кандидата медицинских наук. Башкирский государственный медицинский университет. –2021. – с. 46. [Teryushkova ZhI. Novyye tekhnologii prokhozhdeniya postluchevykh povrezhdeniy pryamoy kishki: spetsial’nost’ 3.1.9 «Khirurgiya» [New technologies in the tre atment of post-radiation injuries of the rectum: specialty 3.1.9 «Surgery»]. Avtoreferat dissertatsii na soiskaniye uchenoy stepeni kandidata vysshikh nauk. Bashkirskiy gosudarstvennyy meditsinskiy universitet [Abstract of the dissertation for the degree of candidate of medical sciences. Bashkir State Medical University]. 2021; s. 46. (In Russ.)].

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UDC 618.11-008.64

DOI: 10.20969/VSKM.2023.16(3).48-53

PDF download A MODERN SOCIO-SOMATIC PORTRAIT OF A WOMAN WITH PATHOLOGICAL CLIMAX

MARDIEVA REZEDA R., ORCID ID: 0000-0003-2568-0121; Assistant professor of the Department of Obstetrics and Gynecology, Kazan State Medical Academy, Russia, 420012, Kazan, st. Mushtari, 11, obstetrician-gynecologist in City Clinical Hospital No7, Russia, 420132, Kazan, Marshal Chuikov st, 56, e-mail: rezedamardieva@gmail.com

MAZITOVA MADINA I., ORCID ID: 0000-0002-9608-2076; D.Med.Sci., Professor of the Department of Obstetrics and Gynecology, Kazan State Medical Academy, Russia, 420012, Kazan, Mushtari st, 11, obstetrician-gynecologist of the Institute of Health and Longevity «Razumed», Russia, 420111, Kazan, Kirova lane, 2a, e-mail: madina13@list.ru

MAZITOV DANIIAR A., ORCID ID: 0000-0003-1305-4377; Junior Researcher in Laboratory of Intelligent Chemical Robotics, Department of Organic Chemistry, Institute of Chemistry named after A.M. Butlerov, Kazan Federal University, Russia, 420111, Kazan, Kremlevskaya st, 29, building 1, Neural network developer at Z-Union, e-mail: daniyarttt@ gmail.com

FAUSTOVA KARINA V., ORCID ID: 0000-0001-8702-0159; Resident of the Department of Obstetrics and Gynecology, Kazan State Medical Academy, Russia, 420012, Kazan, Mushtari st, 11, e-mail: faustova_rina@mail.ru

GARAFIEVA SALIMA M., ORCID ID: 0000-0002-5547-8277; Student, University of Manchester, Oxford Rd, Manchester M13 9PL, UK, e-mail: Salima.gara eva@gmail.com

Abstract. Introduction. Nowadays, the number of menopausal women in the world population has strong tendency to increase. According to statistics the majority have a moderate and severe course of it. This is the reason preventive gerontology develops today, especially climatology. That is why using new machine learning technologies is relevant today. Such method as gradient boosting helped us to identify the characteristic features and factors that cause the pathological course of menopause in women which made it possible to draw up a medical «portrait» of such patients. Using the knowledge of these factors in uence it is easily to recognize women needs to be observed even before the manifestations of menopause. Aim. The aim of the study is to conduct a socio-somatic «portrait» of a modern patient with a pathological menopause. Material and methods. A detailed survey of 1275 women aged 45–60 years was carried out with an assessment of the socio-cultural status, general somatic and gynecological health. The received data were sorted and categorized using modern statistical processing methods and machine learning method - gradient boosting. Results and discussion. Firstly, there are factors with high in uence on menopausal syndrome developing: level of education, oncological anamnesis, diseases of the gastrointestinal tract, vegetative and insomnia disorders, the use of intrauterine contraceptives, the number of children 2 or more, the presence of abortions in anamnesis. The rest of the questionnaires were characterized as having only a small impact. This is a pathology of the thyroid gland, the cardiovascular system; hyperplastic processes in history; occupation, namely social and medical workers, as well as a negative attitude towards menopause. The greater number of these features one woman has, the higher the likelihood of developing a pathological menopause she gets. Conclusion. The collective image we have received of a modern patient with pathological menopausal syndrome is based on aspects of the life and health of women which it is worth paying attention on. This can serve as a kind of guideline for clinicians in order to achieve correction of hypoestrogenism with the development of a pathological menopause.

Keywords: menopausal syndrome, menopause, menopause, machine learning, gradient boosting, modern portrait.

For reference: Mardieva RR, Mazitova MI, Mazitov DA, et al. A modern socio-somatic portrait of a woman with pathological climax. The Bulletin of Contemporary Clinical Medicine. 2023; 16(3): 48-53. DOI: 10.20969/VSKM.2023.16(3).48-53.

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UDC 616.12-008.331.1-053.81-07:616.153.915-074

DOI: 10.20969/VSKM.2023.16(3).54-61

PDF download ASSESSMENT OF THE PREDICTIVE CAPABILITY OF ARTIFICIAL INTELLIGENCE METHODS IN THE PREDICTION OF CARDIOVASCULAR EVENTS

NEVZOROVA VERA A., ORCID ID: 0000-0002-0117-0349, SCOPUS Author ID:6603425593; D. Med. Sci., professor, director of the Institute of therapy and instrumental diagnostics of Paci c State Medical University, Russia, 690002, Vladivostok, Ostryakov ave., 2, e-mail: nevzorova@inbox.ru (mailto:nevzorova@inbox.ru)

PLEKHOVA NATALIA G., ORCID ID: 0000-0002-8701-7213; SCOPUS Author ID: 6603245380; D. Bio. Sci., the Head of Central research laboratory of Paci c State Medical University, Russia, 690002, Vladivostok, Ostryakov ave., 2, tel. 8(423)242-97-78, e-mail: pl_nat@hotmail.com (mailto:pl_nat@hotmail.com)

CHERNENKO IVAN N., ORCID ID: 0000-0001-5261-810X; D. Bio. Sci., the Head of Central research laboratory of Paci c State Medical University, Russia, 690002, Vladivostok, Ostryakov ave., 2, tel. 8(423)242-97-78, e-mail: chernencrj2010@mail.ru (mailto:chernencrj2010@mail.ru)

PRISEKO LUDMILA G., ORCID ID: 0000-0002-3946-2064, postgraduate student (scienti c specialty 3.1.18 «Internal Medicine»), teacher at the Institute of Therapy and Instrumental Diagnostics of the Paci c State Medical University; Address: 2, Ostryakova ave., Vladivostok, Russian Federation 690002; Phone: 89147237764; e-mail: ludmilka.95.95@ yandex.ru (mailto: udmilka.95.95@yandex.ru)

MENOVSHCHIKOVA ANNA K., ORCID ID: 0000-0002-2375-6973; student of the 5th year of education of the Paci c State Medical University; Address: 2, Ostryakova ave., Vladivostok, Russian Federation 690002; Phone: 89243336797; e-mail: menovshhikovaan@mail.ru (mailto: menovshhikovaan@mail.ru)

Abstract. Introduction. Predicting the risk of cardiovascular diseases and adverse outcomes are a promising direction in medicine. Using machine learning methods to process large databases to identify new predictors and establish more complex and deeper interactions between them creates other predictive capabilities in a personalized approach to risk assessment. The new approach to improving forecasting is the ability to use arti cial intelligence techniques by creating a combination of sophisticated mathematical models and algorithms under certain conditions of computational power and improved database quality. Aim. To estimate the accuracy and reliability of models based on machine learning for solving problems of cardiovascular disease risk prediction. Materials and Methods. Data from a one-stage anonymous survey of volunteers in Primorsky Krai were collected in a multicenter observational study «Epidemiology of Cardiovascular Diseases in the Regions of the Russian Federation». A total of 2 131 participants took part in the study. The main and additional predictors of cardiovascular diseases were selected for further analysis and inclusion in prediction models. Models were created and evaluated using statistical and neural network libraries of the Python programming language. The quality of the models was determined by calculating the total area under the receiver operating characteristic curve. Results and discussion. Compared to the established risk prediction algorithm by calculating the area under the receiver operating characteristic curve, machine-learning algorithms improved the prediction: random forest +1.7%, logistic regression +3.2%, neural networks +3.6%. The algorithm with the highest performance (neural networks) predicted 320 cases (sensitivity 70.2%) and 1217 non-cases (speci city 74.7%), correctly predicting 248 (+7.6%) more patients who developed cardiovascular disease compared to the established absolute cardiovascular risk calculation scale Systematic Coronary Risk Evaluation. Conclusion. The use of neural networks with multilayer perceptron, as one of the methods of layer-by-layer construction of machine learning algorithm, is the best option for creating a prognostic model and currently provides the most reliable results.

Key words: cardiovascular risk, cardiovascular disease, Python, neural network, Random Forest.

For reference: Nevzorova VA, Plekhova NG, Chernenko IN, et al. Assessment of the predictive capability of arti cial intelligence methods in the prediction of cardiovascular events. The Bulletin of Contemporary Clinical Medicine. 2023; 16(3): 54-61. DOI: 10.20969/VSKM.2023.16(3).54-61.

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UDC: 616.127-005.8:616.24-007.272-036.12:612.014.464

DOI: 10.20969/VSKM.2023.16(3).62-67

PDF download OXIDATIVE STRESS SEVERITY IN PATIENTS WITH MYOCARDIAL INFARCTION AND COPD

PROKOFYEVA TATIANA V., ORCID ID: 0000-0002-3260-2677; C. Med. Sci., associate professor of the Internal Medicine Department of Pediatric Department, Astrakhan State Medical University, Astrakhan, 54-170 Pobedy St., 414040, Russia, Astrakhan, e-mail: prokofeva-73@inbox.ru

POLUNINA OLGA S., ORCID ID: 0000-0001-8299-6582, D. Med. Sci., Professor, Head of Internal Medicine Department of Pediatric Department, Astrakhan State Medical University, 414000, Russia, Astrakhan, Bakinskaya str. 121, e-mail: admed@yandex.ru

Abstract. Introduction. Oxidative stress is a pathogenetic link in the development of many diseases, including pathology of the respiratory system and cardiovascular events. Comorbidity is a topical problem of modern medicine. One of the frequent combinations is myocardial infarction against the background of chronic obstructive pulmonary disease. The peculiarities of changes in protein and lipid peroxidation, as well as the state of antioxidant protection in comorbid patients are of interest. Aim. To study protein and lipid peroxidation processes in patients with myocardial infarction against the background of chronic obstructive pulmonary disease. Material and Methods: 195 patients with myocardial infarction against the background of chronic obstructive pulmonary disease were examined. Comparison groups were represented by 130 patients with myocardial infarction without chronic obstructive pulmonary disease and 104 patients with chronic obstructive pulmonary disease. The control group included 110 somatically healthy individuals. The level of malondialdehyde was assessed as a marker of lipid peroxidation, the level of deep protein oxidation products was assessed as a marker of free radical oxidation of proteins. Antioxidant protection was assessed using plasma level of total superoxide dismutase. To evaluate non-enzymatic components of antioxidant protection, total serum antioxidant status was determined by spectroscopy. The data were statistically processed using the SPSS 26.0 software package. Results and discussion. In patients with chronic obstructive pulmonary disease the levels of protein and lipid oxidation markers were higher than in myocardial infarction. The highest levels were noted in comorbid patients. Antioxidant levels were decreased in all groups compared to controls. Patients with monosomatic myocardial infarction had lower levels of antioxidants compared with patients with chronic obstructive pulmonary disease. The lowest values were observed in the group of comorbid patients. Conclusion. Chronic obstructive pulmonary disease is accompanied by a more pronounced activation of lipid and protein peroxidation processes, but accompanied by activation of adaptive mechanisms, which is not observed in acute coronary pathology. The greatest severity of oxidative stress is characteristic of comorbid patients.

Key words: myocardial infarction, chronic obstructive pulmonary disease, comorbidity, oxidative stress, protein and lipid peroxidation.

For reference: Prokofyeva TV, Polunina OS. Oxidative stress severity in patients with myocardial infarction and COPD. The Bulletin of Contemporary Clinical Medicine. 2023; 16(3): 62-67. DOI: 10.20969/VSKM.2023.16(3).62-67.

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  1. Григорьева Н.Ю., Майорова М.В., Королёва М.Е., Самолюк М.О. Особенности формирования и раз-вития сердечно-сосудистых заболеваний у больных хронической обструктивной болезнью легких // Тера-певтический архив. – 2019. – Т. 91, вып. 1. – С.16-47. [Grigor’eva NY, Majorova MV, Korolyova ME, Samolyuk MO. Osobennosti formirovaniya i razvitiya serdechno- sosudistyh zabolevanij u bol’nyh hronicheskoj obstruktivnoj bolezn’yu legkih [Peculiarities of formation and development of cardiovascular diseases in patients with chronic obstructive pulmonary disease]. Terapevticheskij arhiv [Therapeutic Archive]. 2019; 91 (1): 16–47. (In Russ.)]. DOI: 10.26442/00403660.2019.01.000027

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  3. Филиппова М.О., Севостьянова И.В., Полунина Е.А. Свободно-радикальная модификация белков и ли-пидов при фибрилляции предсердий // Кубанский научный медицинский вестник. – 2016. – Том 6, вып. 161. – С.131-135. [Filippova MO, Sevost’yanova IV, Polunina EA. Svobodno-radikal’naya modi kaciya belkov i lipidov pri brillyacii predserdij [Free-radical modi cation of proteins and lipids in atrial brillation]. Kubanskij nauchnyj medicinskij vestnik [Kuban Scienti c Medical Bulletin]. 2016; 6 (161): 131-135. (In Russ.)]. https://ksma.elpub.ru/jour/article/view/642/643

  4. Мамедова Ф.И. Влияние оксидативного стресса на состояние эндотелия у пациентов с сердечной недо-статочностью и сахарным диабетом 2-го типа // Ка-занский медицинский журнал. – 2020. – Том 101, вып. 1. – С.13-17. [Mamedova FI. Vliyanie oksidativnogo stressa na sostoyanie endoteliya u pacientov s serdechnoj nedostatochnost’yu i saharnym diabetom 2-go tipa [E ect of oxidative stress on endothelial status in patients with heart failure and type 2 diabetes mellitus]. Kazanskij medicinskij zhurnal [Kazan Medical Journal]. 2020; 101 (1): 13-17. (In Russ.)]. DOI: 10.17816/ KMJ2020-13

14. Эфендиев А.М., Мамедова Ф.И., Азизова Г.И., Да-дашова А.Р. Прогностическая значимость факторов апоптоза и оксидативного стресса при хронической сердечной недостаточности // Сибирский меди-цинский журнал (Иркутск). – 2018. – No2. – С.13-16. Efendiev AM, Mamedova FI, Azizova GI, Dadashova AR. Prognosticheskaya znachimost’ faktorov apoptoza i oksidativnogo stressa pri hronicheskoj serdechnoj nedostatochnosti [Prognostic signi cance of apoptosis and oxidative stress factors in chronic heart failure]. Sibirskij medicinskij zhurnal (Irkutsk) [Siberian Medical Journal (Irkutsk)]. 2018; 2: 13-16. (In Russ.)]. https://cyberleninka.ru/article/n/prognosticheskaya- znachimost-faktorov-apoptoza-i-oksidativnogo-stressa- pri-hronicheskoy-serdechnoy-nedostatochnosti/viewer

15. Панасенкова Ю.С., Павлюченко И.И., Коков Е.А., Охременко О.С. Показатели окислительного стрес-са у пациентов с хронической обструктивной бо-лезнью легких различной степени тяжести в ста-дии обострения // Кубанский научный медицинский вестник. – 2015. – Том 4, вып. 153. – С.106-109. [Panasenkova YuS, Pavlyuchenko II, Kokov EA, Ohremenko OS. Pokazateli oksilitel’nogo stressa u pacientov s hronicheskoj obstruktivnoj bolezn’yu legkih razlichnoj stepeni tyazhesti v stadii obostreniya [Metrics of oxidative stress in patients with chronic obstructive pulmonary disease of varying severity in the acute stage]. Kubanskij nauchnyj medicinskij vestnik [Kuban Scienti c Medical Bulletin]. 2015; 4 (153): 106-109. (In Russ.)]. https://ksma.elpub.ru/jour/article/view/372/373

16. Павлюченко И.И., Коков Е.А., Кокова Л.Н., Охремен-ко О.С. Влияние фенотипа заболевания на показа-тели системы антиоксидантной защиты и уровень некоторых интерлейкинов крови у пациентов с хро-нической обструктивной болезнью легких // Педи-атр. – 2017. – Т. 8, вып. 6. –С.38-41. [Pavlyuchenko II, Kokov EA, Kokova LN, Ohremenko OS. Vliyanie fenotipa zabolevaniya na pokazateli sistemy antioksidantnoj zashchity i uroven’ nekotoryh interlejkinov krovi u pacientov s hronicheskoj obstruktivnoj bolezn’yu legkih [In uence of disease phenotype on antioxidant defense system parameters and levels of some blood interleukins in patients with chronic obstructive pulmonary disease]. Pediatr [Pediatr]. 2017; 8 (6): 38-41. (In Russ.)]. DOI: 10.17816/PED8638-41

17. Четвертое универсальное определение инфаркта ми-окарда. – 2018. [Chetvertoe universal’noe opredelenie infarkta miokarda [The fourth universal de nition of myocardial infarction]. 2018. (In Russ.)]. https:// russjcardiol.elpub.ru/jour/article/viewFile/3259/2531

18. Global Initiative for Chronic Obstructive Lung Disease. 2022; 177 p. GOLD-REPORT-2022-v1.1-22Nov2021_ WMV.pdf

 

UDC 616.127-005.8

DOI: 10.20969/VSKM.2023.16(3).68-76

PDF download THE ASSESSMENT OF THE RELATIONSHIP SIGNIFICANCE BETWEEN VASCULAR REMODELING, INFLAMMATORY RESPONSE AND POLYMORPHISM OF ENDOTHELIAL DYSFUNCTION GENES IN MALE PATIENTS WITH MYOCARDIAL INFARCTION DUE TO HYPERTENTION HISTORY

SADIKOVA REGINA I., ORCID ID: 0000-0002-6653-9194; C. Med. Sci., Assistant professor of the Department of advanced internal medicine No 1, Bashkir State Medical University, Russia, 450000, Ufa, Lenin str., 3, e-mail: regina281210@yandex.ru

MUTALOVA ELVIRA G., ORCID ID: 0000-0002-7454-9819; D. Med. Sci., professor, the Head of the Department of advanced internal medicine No 1, Bashkir State Medical University, Russia, 450000, Ufa, Lenin str., 3, e-mail: emutalova@mail.ru

FRID SVETLANA A., ORCID ID: 000-0003-0131-4266; C. Med. Sci., associate professor of the Department of advanced internal medicine No 1, Bashkir State Medical University, Russia, 450000, Ufa, Lenin str., 3, e-mail: valex69@mail.ru

NIGMATULLINA ALBINA E., ORCID ID: 0000-0002-3511-8477; C. Med. Sci., associate professor of the Department of advanced internal medicine No 1, Bashkir State Medical University, Russia, 450000, Ufa, Lenin str., 3, e-mail: e-mail: albanigma@mail.ru

Abstract. Introduction. Endothelial dysfunction, arterial hypertension and surrogate events of myocardial infarction are interrelated phenomena, while the genetic predisposition in these patients is an independent risk factor for the development of cardiovascular pathology. Aim. The aim of the study was to evaluate the signi cance of the interaction of associations of polymorphic loci of adhesion molecule genes (immunoglobulin VCAM1), MCP-1 chemokine, vascular endothelial growth factor (VEGFA), nitric oxide control enzyme (DDAH1), markers of the in ammatory response, vascular remodeling and endothelial dysfunction in patients with male myocardial infarction, depending on the presence or absence of arterial hypertension in history in the development of myocardial infarction. Material and methods. 667 male patients and 621 practically healthy individuals in the comparison group were examined. Patients underwent determination of general clinical parameters, serum concentrations of monocyte-chemoattractant protein-1 (MCP-1), vascular endothelial growth factor (VEGFA), cytokines (IL-1,6; TNF-α), molecular genetic study, measurement of media intima thickness of the common carotid artery. Selected in the group of patients with myocardial infarction, individuals with or without a history of arterial hypertension. Results and discussion. As a result of a comparative analysis of groups of patients with and without a history of arterial hypertension with a group of healthy individuals, signi cant di erences in the frequencies of genotypes and alleles for the following polymorphic gene loci were revealed: MCP-1, VEGFA, DDAH1, VCAM1. The serum concentration of cytokines (IL-1,6; TNF-α) in patients, regardless of the presence or absence of a history of hypertension, signi cantly exceeded the level in the comparison group. The VEGFA index in patients with myocardial infarction with arterial hypertension was signi cantly increased compared to the serum level in patients with myocardial infarction without arterial hypertension. Conclusion. A higher signi cance of the interaction between indicators of vascular remodeling, in ammation, endothelial dysfunction gene polymorphism in the development of myocardial infarction in patients with a history of hypertension, in contrast to non-hypertensive patients with myocardial infarction, was revealed, which indicates a powerful contribution of arterial hypertension to the etiology and implementation of myocardial infarction.

Key words: myocardial infarction, arterial hypertension, endothelial dysfunction, cytokines, monocytic chemoattractant protein-1, vascular endothelial growth factor.

For reference: Sadikova RI, Mutalova EG, Frid SA, Nigmatullina AE. The assessment of the relationship signi cance between vascular remodeling, in ammatory response and polymorphism of endothelial dysfunction genes in male patients with myocardial infarction due to hypertention history. The Bulletin of Contemporary Clinical Medicine. 2023; 16(3): 68-76. DOI: 10.20969/VSKM.2023.16(3).68-76.

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UDC 616.89-02:616.892-616.1/.4-0728

DOI: 10.20969/VSKM.2023.16(3).77-83

PDF download COMPREHENSIVE ASSESSMENT OF CLINICAL-SYNDROMIC AND SOCIO- PSYCHOLOGICAL CHARACTERISTICS OF PATIENTS WITH SOMATOFORM DISORDERS AND WORKING IN THE NUCLEAR INDUSTRY

SINEUTSKAYA EKATERINA O., ORCID ID: 0000-0002-7253-9828; SPIN-код: 2156-1060, AuthorID: 1173308; Head of the inpatient department, psychiatrist, psychotherapist. Center for the Study of Eating Disorders, Russia, 325589, Moscow, Polessky proezd 16, page 6, e-mail: juna-rom@mail.ru

PETROV DMITRY SERG., ORCID ID: 0000-0002-7869-8643; SPIN-код: 5340-7683, AuthorID: 759678, Doctor of Medical Sciences, Head of the Department of Psychological Counseling and Psychotherapy with the course of Psychiatry; Ryazan State Medical University named after Academician I.P. Pavlov, Russia, Ryazan, st. Vysokovoltnaya, 9, e-mail: Petrovds@list.ru

VOLODIN BORIS YURI., ORCID ID: 0000-0001-7355-4483; SPIN-код: 8374-0562, AuthorID: 758056, Doctor of Medical Sciences, professor of the Department of Psychological Counseling and Psychotherapy with the course of Psychiatry; Ryazan State Medical University named after Academician I.P. Pavlov, Russia, Ryazan, st. Vysokovoltnaya, 9, e-mail: borisvolodin@rambler.ru

SHULAEV ALEXEY V., ORCID ID: 0000-0002-2073-2538; Scopus Author ID 57313158200, SPIN-код: 3229-1913, AuthorID: 210271, Doctor of Medical Sciences, professor, vice-Rector for Clinical Work, Head of the Department of General Hygiene of Kazan State Medical University, Russia, Kazan, st. Butlerova, 49, e-mail: alexs_shu@mail.ru

KONOVALOV OLEG EV., ORCID ID: 0000-0003-1974-9882; Scopus Author ID 7006781195; SPIN-код: 5181-8547, AuthorID: 250753, Doctor of Medical Sciences, professor of the Department of Public Health, Health Care and Hygiene of the Federal State Autonomous Educational Institution of Higher Education Russian University of Peoples’ Friendship of the Ministry of Education and Science of Russia, Russia, Moscow, st. Miklukho-Maklaya, 10, bldg. 2, e-mail: konovalov_oe@mail.ru

Abstract. Introduction. The paper presents the results of a study of the quality of life, individual psychological characteristics, clinical and syndromic picture of somatoform disorders of 90 patients admitted for inpatient treatment at the Federal State Budgetary Institution «Central Psychiatric Hospital of the Federal Medical and Biological Agency» of Russia. Material and methods. The examination was conducted in two groups of 45 patients: the main group - women employees of nuclear production and the control group, including people working under normal conditions. The assessment of the level of alexithymia, quality of life, individual psychological characteristics of patients and features of the clinical picture of somatoform disorders in patients working in the nuclear industry was carried out. Results and discussion. The patients employed in nuclear production mainly su ered from somatized disorder (71.1%), hypochondriac disorder (20.0%) and, most rarely, somatoform dysfunction of the autonomic nervous system (8.9%). Psychopathological symptoms of somatoform disorders in nuclear industry employees are characterized by asthenic and senestopathic syndromes. The indicators for assessing their quality of life are reduced according to the scales: general health, physical functioning, role-based functioning due to physical condition. Patients working in harmful conditions are at risk due to the high level of alexetimia in somatoform disorders and have di culties with recognizing emotions, feelings and their verbalization. Focusing on the features of the clinical picture of somatoform disorder and timely identi cation of the targets of exposure will allow us to develop in more detail the strategy and tactics of specialized care, improve the social adaptation of patients and, as a result, improve their quality of life. Conclusion.Employees of nuclear production are in a state of increased responsibility, neuropsychic stress, which increases the risk of neurotic disorders. The state of neuroticism may be aggravated by a high level of alexithymia in this group of patients, which probably leads to the formation and maintenance of somatoform disorders. The results obtained indicate the importance of organizing preventive measures aimed at maintaining the health of personnel working in the nuclear industry.

Keywords: somatoform mental disorders, alexithymia, quality of life, nuclear industry.

For reference: Sineutskaya EO, Petrov DS, Volodin BY, at al. Comprehensive assessment of clinical-syndromic and socio-psychological characteristics of patients with somatoform disorders and working in the nuclear industry. The Bulletin of Contemporary Clinical Medicine. 2023; 16(3): 77-83. DOI: 10.20969/VSKM.2023.16(3).77-83.

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UDC 616.211/.22-008.4-091

DOI: 10.20969/VSKM.2023.16(3).84-89

PDF download PATHOMORPHOLOGICAL CHANGES OF THE UPPER RESPIRATORY TRACT IN PATIENTS SUFFERING FROM SNORING AND OBSTRUCTIVE SLEEP APNEA SYNDROM

STARKOVA LARISA N., ORCID ID: 0000-0001-8945-2529, Web of Science Researcher ID CAJ-1638-2022, C. Med. Sci. Associate Professor, Department of Surgical Dentistry, Maxillofacial Surgery with the course of otorhinolaryngology of the Ryazan State Medical University named after I.P Pavlov, Russia, Ryazan 39000, Vysokovoltnaya 9, e-mail: starkovalarisa12235@ gmail.com

PICHTILEVA NATALIA A., ORCID ID: 0000-0003-1253-9719, Web of Science Researcher ID CAJ-1847-2022 Assistant Professor of the Department of Surgical Dentistry, Maxillofacial Surgery with the course of otorhinolaryngology of the Ryazan State Medical University named after I. P. Pavlov, Ryazan, Russia 39000, Vysokovoltnaya 9, com 89209616078, pixtileva@gmail

Abstract. Introduction. The most common cause of snoring with periodic stops of breathing during sleep is considered to be obstruction of the pharynx at the level of the soft palate. Similar changes in the soft palate can occur as a secondary in ammatory process in diseases of the pharynx and nose. Aim. The aim of the study is to study histological changes in the soft tissues of the upper respiratory tract, in patients with snoring and obstructive sleep apnea syndrome. Material and methods. Pathomorphological studies of soft tissues of the upper respiratory tract of 57 patients with snoring and obstructive sleep apnea syndrome resected during uvulopalatopharyngoplasty were performed. Results and discussion. Morphological studies of the soft palate resected in patients with snoring revealed changes in almost all tissues of the upper respiratory tract already in the initial stages of the disease. Our research revealed multiple pathological changes characteristic of chronic productive nonspeci c in ammation in the form of hyperplasia of the lymphoid tissue of the lingual and palatine tonsils, multilayered squamous epithelium, mucous glands with retention of mucosal secretions, in ammatory in ltration of all studied tissues with dilation and fullness of their vessels, hypertrophy and atrophy of the muscle bers of the soft palate with brinous and fatty inclusions between them. Conclusion. Comparison of the results of clinical, anthropological and histological studies suggests that pathological changes characteristic of chronic productive nonspeci c in ammation have been revealed in the soft palate: glandular hyperplasia with retention of mucosal secretions, in ammatory in ltration with vasodilation and fullness of blood vessels, hypertrophy and atrophy of muscle bers with brous and fatty inclusions between them.

Keywords: soft palate, lower nasal concha, lingual tonsil hyperplasia, chronic tonsillitis.

For reference: Starkova LN, Pichtileva NA. Pathomorphological changes of the upper respiratory tract in patients su ering from snoring and obstructive sleep apnea syndrome.The Bulletin of Contemporary Clinical Medicine. 2023; 16(3): 84-89. DOI: 10.20969/VSKM.2023.16(3).84-89.

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REVIEWS

UDC: 616.12-008.331.1-02

DOI: 10.20969/VSKM.2023.16(3).90-96

PDF download THE IMPACT OF GENETIC AND EPIGENETIC FACTORS ON THE DEVELOPMENT OF ARTERIAL HYPERTENSION

SADYKOVA AIDA R., ORCID ID: 0000-0001-8324-2424; С. Med. Sci., associate professor, Department of Internal Diseases of Kazan State Medical University, 49 Butlerov Str., 420012, Kazan, Russia, tel.: +7 (843) 236-93-03, e-mail: aidasad@mail.ru

PILIPCHUK SVETLANA A., ORCID ID: 0009-0004-5164-8146; Student of Kazan State Medical University. Address: 49 Butlerov Str., 420012, Kazan, Russia, e-mail: pilipchuk-svetlana@mail.ru

SHAIDULLINA DIANA M., ORCID ID: 0000-0003-0792-062Х; Student of Kazan State Medical University, Address: 49 Butlerov Str., 420012, Kazan, Russia, e-mail: shaidullina2017@mail.ru

MAKAROV MAXIM A., ORCID ID: 0000-0002-4014-4098; С. Med. Sci., associate professor, Department of Internal Diseases of Kazan State Medical University, 49 Butlerov Str., 420012, Kazan, Russia, tel.: +7 (843) 236-93-03, e-mail: maks.vfrfhjd2011@yandex.ru

KHABIBOULLINA RAMZIYA T., ORCID ID: 0009-0002-4037-603X; Deputy Chief Physician of the City Clinical Hospital No11, 34/24 Maximov Str., 420127, Kazan, Russia, e-mail: ramt69@mail.ru

KOZLOVA AIGOUL M., ORCID ID: 0009-0003-4059-7171; the Head of Department of topometric preparation of the Republican Clinical Oncology Dispensary, 29 Sibirskiy Tract Str., 420029, Kazan, Russia, e-mail: aigoul@mail.ru

Abstract. Introduction. Arterial hypertension should be considered as a heterogeneous disease, the development of which is based on the interaction of genetic, epigenetic, metabolic and environmental factors. Mistakes in epigenetic mechanisms can lead to the development of arterial hypertension. Therefore, at present, the attention of many specialists is riveted to the study of epigenetic factors. Aim. Тo analyze the results of modern research on the problem of epigenetic factors in uencing the development of hypertension. Material and methods. Review of publications on genetic and epigenetic factors in uencing the development of hypertension was carried out. Results and discussion.The main epigenetic mechanisms are deoxyribonucleic acid methylation, histone con guration, non-coding ribonucleic acid, and the spatial organization of genetic material in the nucleus. Currently, there is more and more evidence that epigenetic factors are involved in changing the phenotype of the vascular endothelium in response to environmental factors. Speci c modi cations of histones can control the expression of endothelial NO-synthetase, disturbances in the production of nitric oxide lead to the predominance of vasoconstriction and an increase in blood pressure. Data have been obtained that histone modi cations are able to modulate gene expression in vascular smooth muscle cells, which leads to an increase in total peripheral vascular resistance, which is also one of the mechanisms for the development of arterial hypertension. Conclusion. Epigenetic factors also in uence the development of arterial hypertension along with genetic, metabolic, electrolyte, and environmental factors. This is important for identifying biological markers for the development of this disease and targets for its pharmacotherapy.

Key words: arterial hypertension, epigenetic factors, genetic factors.

For reference: Sadykova AR, Pilipchuk SA, Shaidullina D et al. The impact of genetic and epigenetic factors on the development of arterial hypertension.The Bulletin of Contemporary Clinical Medicine. 2023; 16(3): 90-96.
DOI: 10.20969/VSKM.2023.16(3).90-96.

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UDC 616.248:616-002.2(091)

DOI: 10.20969/VSKM.2023.16(3).97-105

PDF download EVOLUTION OF UNDERSTANDING THE ROLE OF CHRONIC INFLAMMATION AS A KEY ELEMENT IN ASTHMA PATHOGENESIS

KHAKIMOVA MILYAUSHA R., ORCID ID: 0000-0002-3533-2596; SCOPUS Author ID: 57220855607; Researcher ID: GNW-3481-2022; RSCI Author ID: 1158851; postgraduate student of the Department of Clinical Immunology and Allergology of Kazan State Medical University, Russia, 420012, Kazan, Butlerov Str., 49; e-mail: mileushe7@gmail.com

Abstract. Introduction. Asthma is considered as a heterogeneous disease. Recently, the pathophysiological mechanisms of chronic airway in ammation development have been established. However, the evolution of understanding the asthma pathogenesis is a matter of great interest. Aim. Based on literature review, our aim was to provide the key milestones in the formation of modern understandings in asthma etiology and pathogenesis. Material and methods. We searched across PubMed and eLibrary.ru databases to identify articles published in 1900-2022, using the keywords ‘bronchial asthma’, ‘history’, ‘pathogenesis’, ‘eosinophilic in ammation’, ‘endotypes’, ‘biomarkers’, ‘innate lymphoid cells’ and ‘Th2 lymphocytes’. Results and discussion. Since ancient times scientists were interested in the mechanisms of asthma development. ‘Asthma’ derived from Greek word that means ‘shortness of breath’ and ‘su ocation’. In the Middle Ages, science was scholasticism oriented, so the understandings of asthma were based only on observational studies, and the works of Hippocrates and Galen were considered irrefutable. Subsequently, in Modern times observational studies were supported by experiments and that gave the opportunity to study the asthma pathogenesis. Since the 20th century studies on identifying the roles of heredity, sensitization and mechanisms of airway in ammation have ourished and that led to the identi cation of asthma endotypes and phenotypes. Recent trends in the understanding of pathogenesis at molecular levels provided a personalized approach to asthma treatment.Conclusion. Thus, accumulated clinical observational and experimental data gained new insights into asthma pathogenesis and led to the development of biologics for the management of asthma. This study was funded by grant from Kazan State Medical University N2/22-10 (02.08.2022).

Key words: bronchial asthma, history, pathogenesis, eosinophilic in ammation, biomarkers.

For reference: Khakimova MR. Evolution of understanding the role of chronic in ammation as a key element in asthma pathogenesis. The Bulletin of Contemporary Clinical Medicine. 2023; 16(3): 97-105.
DOI: 10.20969/VSKM.2023.16(3).97-105.

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CLINICAL CASE

UDC: 616.124.2-006.3-053.2114:5

DOI: 10.20969/VSKM.2023.16(3).106-110

PDF download LARGE LEFT VENTRICULAR FIBROMA IN A CHILD

VOLGINA SVETLANA Y., ORCID ID: 0000-0002-4147-2309; D. Med. Sci., professor of the department of Advanced Internal Medicine of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49; e-mail: Volgina_Svetlana@mail.ru

SAGDIEV DANIL A., ORCID ID: 0009-0007-5756-050X; 6th year student of pediatric faculty of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, е-mail: danils43@yandex.ru

NIKOLAEV DMITRIY A., ORCID ID: 0009-0005-6056-6705; 6th year student of pediatric faculty of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, е-mail: dimabrass1@gmail.com

SOLOVIEVA NAILYA A., ORCID ID: 0000-0002-9687-4583; C. Med. Sci., associate professor of the department of Advanced Internal Medicine of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, е-mail: Nailya-soloveva@mail.ru

KULAKOVA GALINA A., ORCID ID: 0000-0003-1741-2629; C. Med. Sci., associate professor of the department of Advanced Internal Medicine of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, е-mail: galinkul@mail.ru

KURMAEVA ELENA A., ORCID ID: 0000-0003-0873-8037; C. Med. Sci., associate professor of the department of Advanced Internal Medicine of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, е-mail: kurmaelena@rambler.ru

Abstract. Introduction. Fibroma is considered as benign solitary tumor, which is the second most common among primary heart tumors in children. It rarely starts to regresses, contributes to the formation of hemodynamic disorders and congestive heart failure, as well as life-threatening arrhythmias, and also can lead to the development of sudden death.Aim. Informing physicians about a rare cardiac broma in children on the example of a clinical case. Material and methods. Describing a clinical case of patient K., 7 months old, who was referred to the cardiac surgery department for a planned operation to remove a left ventricular mass, which was diagnosed prenatally at 32 weeks. Results and discussion. A dynamic observation was carried out, during which, according to echocardiography and magnetic resonance imaging, an increase in the tumor from 35x25 mm to 70x35 mm and the formation of mitral stenosis were noted. The average pressure gradient in the mitral valve increased from 2 to 11 mm Hg there was a limitation of the mobility of its valves. A partial resection of the tumor was performed. Morphological and immunohistochemical studies con rmed the diagnosis of broma. The postoperative period proceeded well. Conclusion. Cardiac bromas in children, regardless to the clinical course of the disease, require long-term monitoring of patients with an electrocardiological study, echocardiography and magnetic resonance imaging method, and if there is a threat of complications, surgical removal of the tumor.

Key words: cardiac broma, child, clinical case.

For reference: Volgina SY, Sagdiev DA, Nikolaev DA et al. Large left ventricular broma in a child: clinical case. The Вulletin of Contemporary Clinical Medicine. 2023. 16(3): 106-110. DOI: 10.20969/VSKM.2023.16(3).106-110.

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