PDF download Download the whole Issue

LEADING ARTICLE

Dynamics and indicators of development of the medical scientific and practical journal «Bulletin of contemporary clinical medicine» over 5 years (from 2018 to 2022)Amirov N.B. (Russia, Kazan), Vizel A.A. (Russia, Kazan),Kim Z.F. (Russia, Kazan), Amirova R.N. (Russia, Kazan),Amirkhanova S.V. (Russia, Kazan), Daminova M.A. (Russia, Kazan), Khairullina A.I. (Russia, Kazan) P. 8

ORIGINAL RESEARCH

Frequency of alleles and genotypes according to allelic variants of CYP2С9*2 and CYP2С9*3 among patients with pain syndrome who took anti-inflammatory drugs Abdashimov Z.B. (Uzbekistan, Tashkent),
Daminova L.T. (Uzbekistan, Tashkent) P. 17

Clinical and social characteristics of the tuberculosis in children and adolescents in KuzbassBryukhacheva E.O. (Russia, Kemerovo),Lukashova E.N. (Russia, Berezovsky), Kholodov A.A. (Russia, Kemerovo), Lavryashina M.B. (Russia, Kemerovo), Pyanzova T.V. (Russia, Kemerovo) P. 23

Clinical and laboratory characteristics of patients with liver damage in the COVID-19 early rehabilitation period Daminova L.T. (Uzbekistan, Tashkent), Adylova D.S. (Uzbekistan, Tashkent), Muminova S.U. (Uzbekistan, Tashkent) P. 29

The significance of classifications of mechanical injuries of the organs of vision for solving the problems of forensic medical examination Indiaminov S.I. (Uzbekistan, Samarkand), Davranova A.E. (Uzbekistan, Samarkand),
Rasulova M.R. (Uzbekistan, Samarkand) P. 34

Analysis of physical performance of football players considering polymorphism of endurance genes Kayumov A.I. (Uzbekistan, Tashkent), Khamrabayeva F.I. (Uzbekistan, Tashkent), Yunusova L.R. (Uzbekistan, Tashkent) P. 40

Clinical characteristics of patients with lipid metabolism disorders in the outpatient practice of a lipidologist Kim Z.F. (Russia, Kazan), Galyvich A.S. (Russia, Kazan),Sadykova D.I. (Russia, Kazan), Shcherbakov S.Yu.  (Russia, Kazan), Nurieva L.M. (Russia, Kazan), Kim E.S. (Russia, Kazan) P. 44

Analysis and assessment of health demographic processes of persons over working age in the Republic of Tatarstan for 2010–2020 Kitaeva E.A. (Russia, Kazan), Galiullin D.A. (Russia, Kazan),Shulaev A.V. (Russia, Kazan), Yusupova L.А. (Russia, Kazan), Kitaev M.R. (Russia, Kazan), Galiullin A.N. (Russia, Kazan) P. 50

Trabecular bone index in assessing the risk of low-energy fractures after courses of polychemotherapy and autologous bone marrow transplantation in patients with Hodgkin’s lymphoma Kitaeva Ju.S. (Russia, Moscow),
Praskurnichy E.A. (Russia, Moscow), Konstantinova T.S. (Russia, Ekaterinburg), Kuznetsova E.V. (Russia, Ekaterinburg) P. 56

Method of surgical treatment of hammer toe with hallux valgus Kosareva M.A. (Russia, Irkutsk), Leonova S.N. (Russia, Irkutsk), Usoltsev I.V. (Russia, Irkutsk) P. 62

Assessment of dexterity of hands in patients after decompression and ventral subaxial fusion Osolodchenko L.V. (Russia, Lipetsk), Travkov D.A. (Russia, Lipetsk), Vereshchako A.V. (Russia, St. Petersburg),Kosygin V.S. (Russia, Lipetsk), Pomerantsev A.A. (Russia, Lipetsk), Starkin A.N. (Russia, Lipetsk) P. 72

The clinical features of recovery in patients who had coronavirus infection (COVID-19) based on the duration of post-covid period and severity of lung parenchymal abnormalities Praskurnichy E.A. (Russia, Moscow), Zenkova S.I. (Russia, Moscow), Trigolosova I.V. (Russia, Moscow), Orlova O.S. (Russia, Moscow), Elezova L.I. (Russia, Moscow), Shmakov N.A. (Russia, Moscow) P. 79

Lung function disorders in patients with ankylosing spondylitis and their dynamics after a new coronavirus infection COVID-19 Savushkina O.I. (Russia, Moscow), Zaytsev A.A. (Russia, Moscow), Malashenko M.M. (Russia, Moscow), Aseeva N.A. (Russia, Moscow), Astanin P.A. (Russia, Moscow), Kryukov E.V. (Russia, St. Petersburg) P. 86

One-year mortality in patients with diabetes mellitus type II after acute anterior myocardial infarction with Q-waveSokueva Kh.Yu. (Russia, Krasnodar) P. 93

The role of fatty acids in the lipid metabolism disorders mechanisms in individuals with alcohol dependent syndrome Solovyeva V.A. (Russia, Arkhangelsk), Leikhter S.N.(Russia, Arkhangelsk), Solovieva N.V. (Russia, Arkhangelsk),Bichkaeva F.A. (Russia, Arkhangelsk), Ishekov N.S. (Russia, Arkhangelsk), Karyakina O.E.(Russia, Arkhangelsk), Soloviev A.G. (Russia, Arkhangelsk),Udovenkova L.P. (Russia, Arkhangelsk), Vilova T.V. (Russia, Arkhangelsk) P. 100

Pregnancy and COVID-19. Perinatal outcomes Khairullina G.R. (Russia, Kazan), Shukrulloev N.R. (Russia, Kazan), Druzhkova E.B. (Russia, Kazan), Galimzyanov I.I. (Russia, Kazan), Zhogina A.S. (Russia, Kazan) P. 109

Endotelial disfunction in assessing of severity of acute pancreatitis Khalimov E.V. (Russia, Izhevsk), Mikhajlov A.Yu. (Russia, Izhevsk), Soloviev A.A. (Russia, Izhevsk), Styazhkina S.N.(Russia, Izhevsk), Vasilieva A.M. (Russia, Izhevsk),Nesterov B.V. (Russia, Izhevsk) P. 117

Analysis of the lethality of polytrauma in multidiscipline hospital Chikaev V.F. (Russia, Kazan), Akhtyamov I.F. (Russia, Kazan), Petukhov D.M. (Russia, Kazan), Delyan A.M.(Russia, Kazan), Sadriev R.R. (Russia, Kazan), Ismagilov D.O. (Russia, Kazan) P. 122

REVIEWS

Analysis of skin grafting methods for extensive burns of the middle and lower third of the face Pavlyuchenko S.V. (Russia, Voronezh), Popov K.V.(Russia, Voronezh), Zhdanov A.I. (Russia, Voronezh),Bulynin V.V., (Russia, Voronezh), Parkhisenko Yu.A. (Russia, Voronezh), Riasnianskaia L.V. (Russia, Voronezh) P. 127

PRACTICAL EXPERIENCE

Calcification of a paraurethral cyst (а clinical case) Mansur A. (Russia, Moscow), Gritskievich А.А. (Russia, Moscow), Kulchenko N.G. (Russia, Moscow), Derevianko T.I. (Russia, Stavropol), Pospelova O.M.(Russia, Moscow), Myandina G.I. (Russia, Moscow),Miroshkina I.V. (Russia, Moscow) P. 134

___

LEADING ARTICLE

UDC 61 (05)"2018/2022": 005

DOI: 10.20969/VSKM.2022.15(6). 7-16

PDF download DYNAMICS AND INDICATORS OF DEVELOPMENT OF THE MEDICAL SCIENTIFIC AND PRACTICAL JOURNAL «BULLETIN OF CONTEMPORARY CLINICAL MEDICINE» OVER 5 YEARS (from 2018 to 2022)

AMIROV NAIL B., ORCID ID: 0000-0003-0009-9103; SCOPUS Authоr ID: 7005357664; D. Med. Sci., professor of the Department of outpatient medicine and general medical practice of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49; deputy chief of science of the Medical and Healthcare Unit of the Ministry of Internal Affairs of the Russian Federation in the Republic of Tatarstan; editor-in-chief of the journal «The Bulletin of Contemporary Clinical Medicine», Russia, 420059, Kazan, Orenburg tract str., 132, tel. +7 (843) 291-26-76, e-mail: namirov@mail.ru

VIZEL ALEXANDER A., D. Med. Sci., professor, the Head of the Department of phthisiopulmonology of Kazan State Medical University, chief freelance pulmonologist of the Ministry of Health of Tatarstan Republic, deputy editor-in-chief of the journal «The Bulletin of Contemporary Clinical Medicine», Russia, 420012, Kazan, Butlerov str., 49, e-mail: lordara@inbox.ru

KIM ZULFIA F., ORCID ID: 0000-0003-4240-3329; C. Med. Sci., associate professor of the Department of internal medicine of Kazan State Medical University, chief freelance cardiologist of the Ministry of Health of Tatarstan; deputy chief of physician for the Medical Department of the State Clinical Hospital No 7, Kazan; executive secretary of the journal «Bulletin of Contemporary Clinical Medicine», Russia, 420103, Kazan, Chuykov str., 54, tel. +7 (917) 255-55-74, e-mail: profz@yandex.ru

AMIROVA RENATA N., expert physician, the Head of personal insurance sales department, «SOGAZ» , chief of the Department of contracts and marketing of the journal «The Bulletin of Contemporary Clinical Medicine», Russia, Kazan, tel. +7 (903) 307-99-47, e-mail: renata1980@mail.ru

AMIRKHANOVA SURIYA V., C. Sociol. Sci., editor of the journal «The Bulletin of Contemporary Clinical Medicine», e-mail: 17suria@gmail.com

DAMINOVA MARIA A., ORCID ID: 0000-0001-6445-0893; C. Med. Sci., assistant professor of the Department of pediatrics and neonatology named after professor E.M. Lepsky of Kazan State Medical Academy – the branch of Russian Medical Academy of Postgraduate Education, scientific secretary of the journal «The Bulletin of Contemporary Clinical Medicine» 2015–2022, Russia, 420012, Kazan, Butlerov str., 36, tel. + 7 (917) 262-47-79, e-mail: daminova-maria@yandex.ru

KHAIRULLINA ALINA I., ORCID ID: 0000-0002-1661-8249; master of public health, Head of the Department of international of the journal «The Bulletin of Contemporary Clinical Medicine», United Arab Emirates, Dubai, e-mail: alina.khayrullina09@gmail.com

Abstract. Introduction. In 2022, 15 years have passed, since the publication of the rst issue of the journal of «Bulletin of Contemporary Clinical Medicine» in november 2008. Aim. To analyze the dynamics of the development of the journal «Bulletin of Contemporary Clinical Medicine» for a 5-year period, from 2018 to 2022, taking into account the materials of the previous analysis 2008-2018. Material and methods. A comparative analysis of all issues of the journal «Bulletin of Contemporary Clinical Medicine» issued during the study period. All documents and resources accompanying the journal were studied, including the journal website, the platforms https://e-library.ru and https://cyberleninka.ru, as well as the previous analysis published in issue 1 for 2018 (https://www.elibrary.ru/contents.asp?id=34834823). When studying the journal materials, the recommendations of the National Bibliographic Science Citation Database (RSCI), the Higher Attestation Commission under the Ministry of Education and Science of the Russian Federation, the Association of Science Editors and Publishers, and experts from the Scopus and Web of Science databases were taken into account.Results and discussion. Over the period covered by the journal more than 2,000 scienti c papers were published under all the main headings of the journal. Among more than 2000 authors, scientists from various regions and cities of the Russian Federation prevailed, from more than 15 countries of the far and neighboring countries. According to the RSCI data for 2021 published on the e-library platform the impact factor of the journal was: two-year impact factor, taking into account citations from all sources = 0,592; ve-year impact factor = 0,458. Among the journals on the subject of «Medicine and Healthcare» journal ranks 32nd out of 599 medical journals (SCIENCE INDEX) and 214th place out of 4258 scienti c journals (overall rating of scienti c journals, the index of the journal in the ranking = 1,838). Conclusion.The journal «Bulletin of Contemporary Clinical Medicine» is a highly signi cant, rapidly developing mass media on the subject of «Medicine and Healthcare». The strategy and dynamics of the journal’s development is assessed as positive.

Key words: medicine and health, medical journal, peer-reviewed journal.

For reference: Amirov NB, Vizel AA, Kim ZF, et al. Dynamics and indicators of the development of the medical scienti c and practical «Bulletin of Contemporary Clinical Medicine» over 5 years (from 2018 to 2022). Bulletin of Contemporary Clinical Medicine. 2022;15(6): 7-16. DOI: 10.20969/VSKM.2022.15(6).7-16.

References

1. http://vskmjournal.org/ru/redkollegiya/glavnyj-redaktor.html

2. http://vskmjournal.org/ru/redkollegiya.html

3. http://vskmjournal.org/ru/pravila.html

4. https://elibrary.ru/project_risc.asp

5. https://elibrary.ru/title_pro le.asp?id=27925

6. http://kazangmu.ru/

7. http://ulrichsweb.com

8. http://vskmjournal.org/en/editorial-board.html

9. http://vskmjournal.org/ru/

10. http://vskmjournal.org/en/

11. Амиров Н.Б., Визель А.А., Даминова М.А. [и др.]. Публикационная этика и редакционная политика журнала «Вестник современной клинической медицины» // Вестник современной клинической медицины. – 2015. – Т. 8, вып. 3. – С.75–80. [Amirov NB, Vizel’ AA, Daminova MA, Amirova RN, et al. Publikacionnaja etika i redakcionnaja politika zhurnala «Vestnik sovremennoj klinicheskoj mediciny» [Publication ethics and editorial policy of journal «The Bulletin of Contemporary Clinical Medicine»]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Contemporary Clinical Medicine]. 2015; 8 (3): 75-80.

12. http://vskmjournal.org/ru/vypuski-zhurnala/29-2010-ru/76- tom-3-vypusk-4-2010.html

13. Амиров Н.Б., Визель А.А., Даминова М.А. [и др.]. Анализ деятельности и развития медицинского научно-практического журнала «Вестник современной клинической медицины» за 10 лет (с 2008 по 2018 год) // Вестник современной клинической медицины – 2018. – Т.11, вып. 1. – С.7–16. [Amirov NB, Vizel AA, Daminova MA, et al. [Analiz deyatel’nosti i razvitiya medicinskogo nauchno-prakticheskogo zhurnala «Vestnik sovremennoj klinicheskoj mediciny» za 10 let (s 2008 po 2018 god) [Analysis of the activities and development of the medical scienti c and practical journal «Bulletin of Contemporary Clinical Medicine» for 10 years (from 2008 to 2018)]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Contemporary Clinical Medicine]. 2018; 11(1): 7-16. (In Russ.)]. DOI: 10.20969/VSKM.2015.11(1).7-16.

 

ORIGINAL RESEARCH

UDC 616-009.7-085.276.065: 275.174.015.3

DOI: 10.20969/VSKM.2022.15(6).17-22

PDF download FREQUENCY OF ALLELES AND GENOTYPES ACCORDING TO ALLELIC VARIANTS OF CYP2С9*2 AND CYP2С9*3 AMONG PATIENTS WITH PAIN SYNDROME WHO TOOK ANTI-INFLAMMATORY DRUGS

ABDASHIMOV ZAFAR B., ORCID ID:0000-0002-7807-9463; PhD, independent applicant of the Department of subjects of therapeutic direction No 2 of Tashkent State Dental Institute, Uzbekistan, 100047, Tashkent, Yashnabad district, Taraqqiyot str., 103, tel. +99 (871) 230-20-73, e-mail: zafar_abdashimov@mail.com

DAMINOVA LOLA T., ORCID ID: 0000-0003-2344-3544; D. Med. Sci., professor of the Department of therapeutic subjects No 2 of Tashkent State Dental Institute, Uzbekistan, 100047, Tashkent, Yashnabad district, Taraqqiyot str., 103, tel. +99 (871) 230-20-73, e-mail: lola.daminova@yandex.ru

Abstract. Introduction. The most clinically signi cant polymorphic markers of the CYP2C9 gene are the amino acid substitutions of CYP2C9*2. One of the types of human cytochrome P450 – cytochrome CYP2C19 plays an important role in the metabolism of certain drugs, including proton pump inhibitors. The genetic polymorphism of СУР2С19 has pronounced interindividual differences. The signi cance of genetic polymorphism is determined when the occurrence of variant alleles is more than 1% in the population. Aim. The aim of the study was to improve the principles of pharmacotherapy of nonsteroidal anti-in ammatory drugs depending on the frequency of alleles and genotypes according to allelic variants of CYP2С9*2 and CYP2С9*3 in patients with pain syndrome, who took nonsteroidal anti-in ammatory drugs. Material and methods. The study included 69 patients with pain syndrome. The study of the association between the carrier of genotypes according to the CYP2С9*2 and CYP2С9*3 alleles and the development of gastropathies with the use of anti-in ammatory drugs was carried out by conducting a prospective case-control study. Molecular genetic studies were carried out on the basis of the Laboratory of Medical Genetics, the Research Institute of Hematology and Blood Transfusion of the Ministry of Health of the Republic of Uzbekistan. Results and discussion. Our data suggest that the carriage of allelic variants of CYP2C9*2 and CYP2C9*3 should be considered as a risk factor for the development of gastropathies when using anti-in ammatory drugs. It can be assumed that in order to reduce the risk of adverse drug reactions when using anti-in ammatory drugs in this category of patients, their joint administration with proton pump inhibitors is necessary. Conclusion. Signi cantly signi cant differences in the frequencies of CYP2C9 and CYP2C19 alleles between groups of patients with and without complications from the gastrointestinal tract while taking anti-in ammatory drugs and proton pump inhibitors. Therefore, it is necessary to further study the frequencies of alleles and genotypes according to the allelic variants of CYP2С9*2 and CYP2С9*3 among patients with pain syndrome who took anti-in ammatory drugs.

Key words: undesirable drug reactions, allelic variants of CYP2C9*2 and CYP2C9*3, pain syndrome, NSAIDs.

For reference: Abdashimov ZB, Daminova LT. Frequency of alleles and genotypes according to allelic variants of CYP2C9*2 and CYP2C9*3 among patients with pain syndrome who took anti-in ammatory drugs. Bulletin of modern clinical medicine. 2022; 15 (6): 17-22. DOI: 10.20969/VSKM.2022.15(6).17-22.

References

  1. Алексеев В.В. Современные представления и основные принципы терапии боли // Русский медицинский журнал. – 2011. – No 1 (спец. вып.). – С. 6–11. [Alekseev VV. Sovremennye predstavleniya i osnovnye principy terapii boli [Modern ideas and basic principles of pain therapy] Russkij medicinskij zhurnal [Russian Medical Journal]. 2011; 1: 6-11. (In Russ.)].

  2. Биккинина Г.М., Сафуанов А.Р. Нежелательные лекарственные реакции нестероидных противовоспалительных препаратов // Молодой ученый. – 2015. – No 7 (87). – С. 269–272. [Bikkinina GM., Laufanov AR. Nezhelatel’nye lekarstvennye reakcii nesteroidnyh protivovospalitel’nyh preparatov [Undesirable drug reactions of nonsteroidal anti-in ammatory drugs]. Molodoj uchenyj [Young scientist]. 2015; 7 (87): 269-272. (In Russ.)]. URL: https://moluch.ru/archive/87/16884

  3. Журавлева М.В., Кукес В.Г., Прокофьев А.Б. [и др.] Рациональное применение НПВП – баланс эффективности и безопасности (обзор литературы) // Международный журнал прикладных и фундаментальных исследований. – 2016. – No 6-4. – С. 687– 696 [Zhuravleva MV, Kukes VG, Prokof’ev AB, et al. Racional’noe primenenie NPVP – balans effektivnosti i bezopasnosti (obzor literatury)] Rational use of NSAIDs – balance of effectiveness and safety (literature review)]. Mezhdunarodnyj zhurnal prikladnyh i fundamental’nyh issledovanij [International Journal of Applied and Fundamental Research]. 2016; 6-4: 687-696. (In Russ.)].

  4. Кукес В.Г., Грачев С.В., Сычев Д.А., Раменская Г.В. Метаболизм лекарственных средств: научные основы персонализированной медицины. – Москва: ГЭОТАР-Медиа, 2008. – 304 с. [Kukes V., Grachev SV, Sychev DA, Ramenskaya GV. Metabolizm lekarstvennyh sredstv: nauchnye osnovy personalizirovannoj mediciny] Drug metabolism: scienti c foundations of personalized medicine]. Moskva: GEOTAR-Media [Moscow: GEOTAR-Media]. 2008; 304. (In Russ.)].

  5. Каратеев А.Е., Насонов Е.Л., Яхно Н.Н. [и др.]. Рациональное применение нестероидных противовоспалительных препаратов (НПВП) в клинической практике: клинические рекомендации // Современная ревматология. – 2015. – No 1. – С.4–23. [Karateev AE, Nasonov EL, Yahno NN, et al. Racional’noe primenenie nesteroidnyh protivovospalitel’nyh preparatov (NPVP) v klinicheskoj praktike: Klinicheskie rekomendacii]. Rational use of nonsteroidal anti-in ammatory drugs (NSAIDs) in clinical practice: Clinical recommendations]. Sovremennaya revmatologiya [Modern rheumatology]. 2015; 1: 4-23. (In Russ.)].

  6. Решетняк В.К., Кукушкин М.Л. Боль: физиологические и патофизиологические аспекты // Актуальные проблемы патофизиологии. Избранные лекции / под ред. Б.Б. Мороза. – Москва: Медицина, 2001. – С.354–389. [Reshetnyak VK, Kukushkin ML. Bol’: ziologicheskie i pato ziologicheskie aspekty. Aktual’nye problemy patoziologii. Izbrannye lekcii / pod red. B.B. Moroza]. Pain: physiological and pathophysiological aspects. Actual problems of pathophysiology. Selected lectures (Edited by B.B. Moroz)]. Moskva: Medicina [Moscow: Medicine]. 2001; 354-389. (In Russ.)].

  7. Ташенова А.И. Транспортная система гликопротеина-Р и фармакокинетика лекарственных средств // Биомедицина. – 2010. – No 4. – С.24–32. [Tashenova AI. Transportnaya sistema glikoproteina-Р i farmakokinetika lekarstvennyh sredstv] Glycoprotein-P transport system and pharmacokinetics of drugs] Biomedicina [Biomedicine]. 2010; 4: 24-32. (In Russ.)].

  8. Якушева Е.Н., Черных И.В., Щулькин А.В., Попова Н.М. Гликопротеин-P: структура, физиологическая роль и молекулярные механизмы модуляции функциональной активности // Успехи физиологических наук. – 2014. – No 45 (4). – С.90–98. [Yakusheva EN, Chernyh IV, Shchul’kin AV, Popova NM. Glikoprotein-P: struktura, fiziologicheskaya rol’ i molekulyarnye mekhanizmy modulyacii funkcional’noj aktivnosti] Glycoprotein-P: structure, physiological role and molecular mechanisms of functional activity modulation] Uspekhi ziologicheskih nauk [Successes of physiological sciences]. 2014; 45 (4): 90-98. (In Russ.)].

  9. Bhala N, Emberson J, Merhi A, et al. Vascular and upper gastrointestinal effects of non-steroidal anti-in ammatory drugs: metaanalyses of individual participant data from randomised trials. Lancet. 2013; 382 (9894): 769-79. DOI: 10.1016/S0140-6736(13)60900-9.

  10. Blondell RD, Azadfard M, Wisniewski AM. Pharmacologic therapy for acute pain. Am Fam Physician. 2013; 87 (11): 766-772.

  11. Crofford LJ. Use of NSAIDs in treating patients with arthritis. Arthritis Res Ther. 2013;15(3): 2. DOI: 10.1186/ ar4174. Epub 2013 Jul 24.

  12. Li Y.H., Wang Y.H., Li Y, Yang L. MDR1 gene polymorphisms and clinical relevance. Yi Chuan Xue Bao. 2006; 33(2): 93-104.

  13. Yiannakopoulou E. Pharmacogenomics of ace-tylsalicylic acid and other nonsteroidal anti-in ammatory agents: clinical implications. Euro J Clan Pharmacology. 2013; 69: 1369-1373.

 

UDC 616-002.5-053.2(471.17)

DOI: 10.20969/VSKM.2022.15(6).23-28

PDF download CLINICAL AND SOCIAL CHARACTERISTICS OF THE TUBERCULOSIS IN CHILDREN AND ADOLESCENTS IN KUZBASS

BRYUKHACHEVA EKATERINA O., ORCID ID: 0000-0001-5212-9234; assistant professor of the Department of phthisiology of Kemerovo State Medical University, Russia, 650029, Kemerovo, Voroshilov str., 22a, tel. 8-384-254-56-51, e-mail: catia.bek@yandex.ru

LUKASHOVA ELENA N., ORCID ID: 0000-0003-3811-0208; chief doctor of the Kuzbass Children’s Sanatorium for Tuberculosis Patients; Chief regional specialist pediatric phthisiatrician of the Ministry of Health of Kuzbass, Russia, 652431, Kemerovo region, Berezovsky city, Barzas settlement, Lenin str., 14a, e-mail: artyomkass96@gmail.com

KHOLODOV ARTYOM A., ORCID ID: 0000-0001-5249-8822; clinical resident of the Department of phthisiology of Kemerovo State Medical University, Russia, 650029, Kemerovo, Voroshilov str., 22a, tel. 8-384-254-56-51, e-mail: artyomkass96@gmail.com

LAVRYASHINA MARIYA B., ORCID ID: 0000-0001-5249-8822; D. Biol. Sci., associate professor, the Head of the Department of molecular and cellular biology of Kemerovo State Medical University, Russia, 650029, Kemerovo, Voroshilov str., 22a, tel. 8-384-254-56-51, e-mail: lmb2001@mail.ru

PYANZOVA TATYANA V., ORCID ID: 0000-0002-4854-5734; D. Med. Sci., associate professor, Vice-rector for scientific, medical work and the development of regional health care, the Head of the Department of phthisiology of Kemerovo State Medical University, Russia, 650029, Kemerovo, Voroshilov str., 22a, e-mail: tatyana_vezhnina@mail.ru

Abstract. Introduction. The incidence of tuberculosis among children and adolescents in the Russian Federation is decreasing annually, but epidemiological indicators are higher in the Siberian Federal District. Aim. The aim of the studyis to study trends in the clinical characteristics of tuberculosis among children and adolescents in the Kemerovo region – Kuzbass in modern conditions. Material and methods. A retrospective continuous study of all cases of tuberculosis in children and adolescents aged 0 to 18 years, detected in the Kemerovo region – Kuzbass in different time periods: the beginning of 2008–2011 (n=634) – the 1st group, and later in 2018–2021 (n=250) – the 2nd group. Results anddiscussion. The data of our study show that against the background of a signi cant decrease in the incidence of children and adolescents in Kuzbass, the age of children with tuberculosis has changed due to a decrease in the proportion of cases aged 4–7 years from 34,5% to 18,4% and an increase in the proportion of children with tuberculosis. Patients aged 13–17 years from 24,9% to 40,0%. Among tuberculosis cases in 2018–2021, in comparison with the earlier period, an increase in the number of non-vaccinated BCG was revealed (p=0,001, OR=7,963), tuberculosis was detected more often in urban residents (p=0,001, OR=4,290), the share of disseminated tuberculosis in the structure of clinical forms increased (p=0,001, OR=39,984) and combined tuberculosis and HIV infection (p=0,001, OR=14,602), the proportion of children and adolescents receiving treatment for drug-resistant forms of tuberculosis (p=0,001, OR=16,084).Conclusion. The incidence of tuberculosis among children and adolescents in Kuzbass has decreased signi cantly in recent years. At the same time, the age of sick children and adolescents is increasing, the proportion of patients with combined tuberculosis and HIV infection is increasing, as well as people receiving chemotherapy treatment for drug-resistant tuberculosis.

Key words: tuberculosis in children, incidence, dynamics of epidemiological indicators

For reference: Bryukhacheva EO, Lukashova EN, Kholodov AA, et al. Clinical and social characteristics of the tuberculosis in children and adolescents in Kuzbass. The Bulletin of Contemporary Clinical Medicine. 2022; 15(6): 23-28. DOI: 10.20969/VSKM.2022.15(6).23-28.

References

1. Аксенова В.А., Клевно Н.И., Кавтарашвили С.М. [и др.]. Очаг туберкулезной инфекции как риск развития у детей туберкулеза с множественной лекарственной устойчивостью // Туберкулез и болезни легких. – 2018. – Т. 96, No 1. – С. 11–17. [Аksenova VА, Klevno NI, Kavtarashvili SM, et al. Ochag tuberkuleznoy infektsii kak risk razvitiya u detey tuberkuleza s mnozhestvennoy lekarstvennoy ustoychivost’yu [The nidus of tuberculous infection as a risk factor of multiple drug resistant tuberculosis in children]. Tuberkulez i bolezni legkikh [Tuberculosis and Lung Diseases]. 2018; 96 (1): 11-17. (In Russ.)]. DOI: 10.21292/2075-1230-2018-96-1-11-17.

2. Эргешов А.Э., Овсянкина Е.С., Губкина М.Ф. [и др.]. Организация противотуберкулезной помощи детям и подросткам из групп риска: взгляд из прошлого на современные проблемы (обзор литературы и комментарий) // Вестник Центрального научно-исследовательского института туберкулеза. – 2020. – No 4. – С. 5–13. [Ergeshov AE, Ovsyankina ES, Gubkina MF, et al. Organizatsiya protivotuberkuleznoy pomoshchi detyam i podrostkam iz grupp riska: vzglyad iz proshlogo na sovremennye problemy (obzor literatury i kommentariy) [Organization of tb services for children and adolescents at risk of tb: a look from the past at current issues (a literature review and a comment)]. Vestnik Tsentral’nogo nauchno-issledovatel’skogo instituta tuberkuleza [CTRI Bulletin]. 2020; 4: 5-13. (In Russ.)]. DOI: 10.7868/ S2587667820040019.

3. Бородулина Е., Санталова Г., Бородулин Б. [и др.]. Туберкулезная инфекция у детей в современных условиях // Врач. – 2016. – No 8. – С. 2–5. [Borodulina EA, Santalova GV, Borodulin BE, et al. Tuberkuleznaya infektsiya u detey v sovremennykh usloviyakh [TB infection in children in modern conditions]. Vrach [Doctor]. 2016; 8: 2-5. (In Russ.)]. https://www.elibrary.ru/download/ elibrary_26710075_43366525.pdf

4. Ароян А.Р., Мордык А.В. Некоторые клинические особенности туберкулеза у детей дошкольного и младшего возраста (опыт Омской области) // Педиатрия. Журнал им. Г.Н. Сперанского. – 2022. – Т. 101, No 1. – С. 178–183. [Aroyan AR, Mordik AV. Nekotorye klinicheskie osobennosti tuberkuleza u detey doshkol’nogo i mladshego vozrasta (opyt Omskoy oblasti) [Selectedclinical characteristic features of tuberculosis in childrenof preschool and primary school age (experience of the Omsk region)]. Pediatriya. Zhurnal im. G.N. Speranskogo [Pediatrics. Journal named after G.N.Speransky]. 2022; 101 (1): 178-183. (In Russ.)]. DOI: 10.24110/0031-403X-2022-101-1-178-183.

5. Аскарова Р.И. Социально значимый туберкулез у детей дошкольного возраста // Наука, техника и образование. – 2022. – Т. 84, No 1. – С. 82–85. [Askarova RI. Sotsial’no znachimyy tuberkulez u detey doshkol’nogo vozrasta [Socially signi cant tuberculosis in preschool children]. Nauka, tekhnika i obrazovanie [Science, technology and education]. 2022; 84 (1): 82-85. (In Russ.)]. DOI: 10.24411/2312-8267-2022-10104.

6. Бармина Н.А., Барышникова Л.А. Возможности повышения эффективности профилактики заболевания у детей в очагах туберкулезной инфекции на примере Пермского края // Туберкулез и болезни легких. – 2018. – Т. 96, No 9. – С. 50–56. [Barmina NA, Baryshnikova LA. Vozmozhnosti povysheniya effektivnosti pro laktiki zabolevaniya u detey v ochagakh tuberkuleznoy infektsii na primere Permskogo kraya [Ways to enhance the ef ciency of tuberculosis prevention in the children exposed to tuberculous infection illustrated by the example of Perm Kray]. Tuberkulez i bolezni legkikh [Tuberculosis and Lung Diseases]. 2018; 96 (9): 50-56. (In Russ.)]. DOI: 10.21292/2075-1230-2018-96-9-50-56.

7. Guidance for national tuberculosis programmes on the management of tuberculosis in children. 2nd ed. Geneva, Switzerland: WHO, 2014. PMID: 24999516.

8. Нечаева О.Б. Эпидемическая ситуация по туберкулезу в России // Туберкулез и болезни легких. – 2018. – Т. 96, No 8. – С. 15–24. [Nechaeva OB. Epidemicheskaya situatsiya po tuberkulezu v Rossii [TB situation in Russia]. Tuberkulez i bolezni legkikh. [Tuberculosis and Lung Diseases]. 2018; 96 (8): 15-24. (In Russ.)]. DOI: 1021292/2075-1230-2018-96-8-15-24.

9. Нечаева О.Б. Туберкулез у детей в России // Туберкулез и болезни легких. – 2020. – Т. 98, No 11. – С. 12–20. [Nechaeva OB. Tuberkulez u detey v Rossii [Tuberculosis in children in Russia]. Tuberkulez i bolezni legkikh [Tuberculosis and Lung Diseases]. 2020; 98 (11): 12-20. (In Russ.)]. DOI: 10.21292/2075-1230-2020-98-11-12-20.

10. Аксенова В.А., Клевно Н.И., Казаков А.В., Ковалевская Е.Б. Короткие курсы химиотерапии у детей с лекарственно-устойчивым туберкулезом // Туберкулез и болезни легких. – 2021. – Т. 99, No 2. – С. 34–39. [Klevno NI, Аksenova VA, Kazakov AV, Kovalevskaya EB. Korotkie kursy khimioterapii u detey s lekarstvenno-ustoychivym tuberkulezom [Short coursechemotherapy in children suffering from drug resistanttuberculosis]. Tuberkulez i bolezni legkikh [Tuberculosis and Lung Diseases]. 2021; 99 (2): 34-39. (In Russ.)]. DOI: 10.21292/2075-1230-2021-99-2-34-39.

11. Ikeda S, Cruz AT, Starke JR. Epidemiology and clinical characteristics of childhood TB identi ed using active and passive case nding. Intern. J. Tuberc. Lung Dis. 2021 Jun 1; 25(6): 475-482. DOI: 10.5588/ijtld.20.0916. PMID: 34049610.

12. Афанасьев Е.И., Русских О.Е. Многолетний срав-нительный анализ основных эпидемиологических показателей по туберкулезу в сочетании с ВИЧ-инфекцией в Удмурской Республике // Туберкулез и болезни легких. – 2020. – Т. 98, No 9. – С. 18–22. [Afanasiev EA, Russkikh OE. Mnogoletniy sravnitel’nyy analiz osnovnykh epidemiologicheskikh pokazateley po tuberkulezu v sochetanii s VICh-infektsiey v Udmurskoy Respublike [Long-term comparative analysis of the mainepidemiological indicators for tuberculosis in combinationwith HIV infection in the Udmurt Republic]. Tuberkulez i bolezni legkikh [Tuberculosis and Lung Diseases]. 2020; 98(9): 18-22. (In Russ.)]. DOI: 10.21292/2075-1230-2020-98-9-18-22.

13. Васильева И.А., Белиловский Е.М., Борисов С.Е. [и др.]. Туберкулез, сочетанный с ВИЧ-инфекцией, в странах мира и Российской Федерации // Туберкулез и болезни легких. – 2017. – Т. 95, No 9. – С. 8–18. [Vasilyeva IA, Belilovsky EM, Borisov SE, et al. Tuberkulez, sochetannyy s VICh-infektsiey, v stranakh mira i Rossiyskoy Federatsii [Tuberculosis w ith concurrent H IV infection in the Russian Federation and the world]. Tuberkulez i bolezni legkikh [Tuberculosis and Lung Diseases]. 2017; 95 (9): P. 8-18. (In Russ.)]. DOI: 10.21292/2075-1230-2017-95-9-8-18.

14. Аксенова В.А., Русакова Л.И., Стерликов С.А. Результаты лечения туберкулеза у детей // Туберкулез и болезни легких. – 2021. – Т. 99, No 10. – С. 7–13. [Аksenova VA, Rusakova LI, Sterlikov SA. Rezul’taty lecheniya tuberkuleza u detey [Tuberculosis treatment outcomes in children]. Tuberkulez i bolezni legkikh [Tuberculosis and Lung Diseases]. 2021; 99(10): 7-13. (In Russ.)]. DOI: 10.21292/2075-1230-2021-99-10-7-13.

15. Бармина Н.А. Организация работы с детьми и подростками в очагах туберкулезной инфекции // Тихоокеанский медицинский журнал. – 2021. – No 2. – С. 80–83. [Barmina NA. Organizatsiya raboty s det’mi i podrostkami v ochagakh tuberkuleznoy infektsii [Organization of work with children and adolescents in the outbreaks of tuberculosis infection]. Tikhookeanskiy meditsinskiy zhurnal [Paci c Medical Journal]. 2021; (2): 80-83. (In Russ.)]. DOI: 10.34215/1609-1175-2021-2-80-83.

16. Васильева И.А., Тестов В.В., Стерликов С.А. Эпидемическая ситуация по туберкулезу в годы пандемии COVID-19 – 2020–2021 гг. // Туберкулез и болезни легких. – 2022. – Т. 100, No 3. – С. 6–16. [Vasilyeva IA, Testov VV, Sterlikov SA. Epidemicheskaya situatsiya po tuberkulezu v gody pandemii COVID-19 – 2020–2021 gg. [Tuberculosis Situation in the Years of the COVID-19 Pandemic – 2020–2021]. Tuberkulez i bolezni legkikh [Tuberculosis and Lung Diseases]. 2022; 100 (3): 6-16. (In Russ.)]. DOI: /10.21292/2075-1230-2022-100-3-6-16.

17. Аксенова В.А., Гордина А.В. Вопросы туберкулеза у детей и подростков в Российской Федерации // Тихоокеанский медицинский журнал. – 2021. – No 1. – С. 80–84. [Aksenova VA, Gordina AV. Voprosy tuberkuleza u dete i podrostkov v Rossi sko Federatsii [Issues on tuberculosis among children and adolescents in Russian Federation]. Tikhookeanski meditsinski zhurnal [Paci c Medical Journal]. 2021; 1: 80-84. (In Russ.)]. DOI: 10.34215/1609-1175-2021-1-80-84.

18. Копылова И.Ф., Лукашова Е.Н., Пьянзова Т.В. Структура клинических форм активного туберкулеза у детей и подростков в динамике за 20 лет // Туберкулез и болезни легких. – 2014. – Т. 91, No 8. – С. 57–58. [Kopylova IF, Lukashova EN, P’yanzova TV. Struktura klinicheskikh form aktivnogo tuberkuleza u detey i podrostkov v dinamike za 20 let [The structure of clinical forms of active tuberculosis in children and adolescents over 20 years]. Tuberkulez i bolezni legkikh [Tuberculosis and Lung Diseases]. 2014; 91 (8): 57-58. (In Russ.)]. DOI: 10.21292/2075-1230-2014-0-8-57-58.

 

UDC 616.36-036.8-07:578.834.1

DOI: 10.20969/VSKM.2022.15(6).29-33

PDF download CLINICAL AND LABORATORY CHARACTERISTICS OF PATIENTS WITH LIVER DAMAGE IN THE COVID-19 EARLY REHABILITATION PERIOD

DAMINOVA LOLA T., ORCID ID: 0000-0003-2344-3544; D. Med. Sci., professor of the Department of therapeutic subjects No 2 of Tashkent State Dental Institute, Uzbekistan, 100047, Tashkent, Yashnabad district, Tarakkiyot str., 103, tel. +99-871-230-20-73, e-mail: lola.daminova@yandex.ru

ADYLOVA DURDONA S., ORCID ID: 0000-0002-5243-1473; candidate of a degree of the Department of internal diseases, nephrology and hemodialysisy of Tashkent Pediatric Medical Institute, Uzbekistan, 100140, Tashkent, Yunusabad district, Bogishamol str., 223, tel. +99-871-262-33-20, e-mail: adilovadurdona7@gmail.com

MUMINOVA SITORA U., ORCID ID: 0000-0003-0119-9288; C. Med. Sci., assistant professor of the Department of endocrinology with pediatric endocrinology of Tashkent Pediatric Medical Institute, Uzbekistan, 100140, Tashkent, Yunusabad district, Bogishamol str., 223, tel. +99-871-262-33-20, e-mail: adilovadurdona7@gmail.com

Abstract. Introduction. The emergence of COVID-19 has set health professionals tasks related to the rapid diagnosis and provision of medical care to patients. Patients with COVID-19 also have extrapulmonary symptoms; including clinical signs of damage to the gastrointestinal tract (GI tract) and the hepatobiliary system which are diagnosed in 26–53% of patients. Aim. The aim of the study was to evaluate clinical and laboratory indicators of liver damage in patients in the early rehabilitation period of COVID-19. Material and methods. There were 243 patients with COVID-19 aged 18–60 years under observation. The criteria for inclusion in the study were: transferred no earlier than 10 days before inclusion in the study COVID-19; at the time of inclusion in the study PCR-negative COVID-19. The indicators of the general blood test, in the blood serum – C-reactive protein, alanine aminotransferase, aspartate aminotransferase, gamma glutamyl aminotransferase, lactate dehydrogenase, alkaline phosphatase, total and direct bilirubin, albumin. Results and dis-cussion. The assessment of the clinical condition of patients showed that the prevalence of respiratory syndrome was 81,48%, dyspeptic – 67,90%, hemorheological – 54,73%, asthenic – 42,39%, encephalopathy – 36,21%. In the general blood test, the hemoglobin level, the number of erythrocytes and platelets were signi cantly lower than in the control group (p<0,001, p<0,05 and p<0,001). The activity of blood enzymes in post COVID-19 patients included in the study was signi cantly increased compared to the control group: alanine aminotransferase exceeded the average values in the control group by almost 10 times, aspartate aminotransferase – almost 3 times, lactate dehydrogenase – 3 times, gamma glutamyl aminotransferase and alkaline phosphatase – almost one and a half times. The level of bilirubin b signi cantly exceeded the indicator recorded in the control group (p<0,001). The concentration of albumin in the peripheral blood of patients was reduced (p<0,001 the signi cance of the difference with the control group). Conclusion. In patients with liver damage in post COVID-19 patients the early rehabilitation period, the most frequent clinical syndromes were respiratory (81,48%) and dyspeptic (67,90%). Laboratory changes characteristic of hypochromic anemia, consumption thrombocytopenia, mesenchymal-in ammatory activity, liver functional disorders (the presence of cytolytic cholestatic syndromes and a decrease in protein synthesizing liver function) were also revealed.

Key words: hepatoprotectors, COVID-19, ursodeoxycholic acid, glycyrrhizic acid, phospholipids.

For reference: Daminova LT, Adylova DS, Muminova SU. Clinical and laboratory characteristics of patients with liver damage in the COVID-19 early rehabilitation period. The Bulletin of Contemporary Clinical Medicine. 2022; 15(6): 29-33. DOI: 10.20969/VSKM.2022.15(6).29-33.

References

  1. Wei WE, Li Z, Chiew CJ, et al. Presymptomatic Transmission of SARS-CoV-2. MMWR Morb Mortal Wkly Rep. 2020; 69(14): 411-415. DOI: 10.15585/mmwr.mm6914e1.

  2. Hundt MA, Deng Y, Ciarleglio MM, et al. Abnormal Liver Tests in COVID-19: A Retrospective Observational Cohort Study of 1,827 Patients in a Major U.S. Hospital Network. Hepatology. 2020; 72: 1169-1176. DOI: 10.1002/ hep.31487.

  3. Gu J, Han B, Wang J. COVID-19: Gastrointestinal Manifestations and Potential Fecal-Oral Transmission. Gastroenterology. 2020; 7: 1518-1519. DOI: 10.1053/j. gastro.2020.02.054.

  4. Brugliera L, Spina A, Castellazzi P, et al. Rehabilitation of COVID-19 patients. J Rehabil Med. 2020; 52(4): 1189-1197. DOI: 10.2340/16501977-2678.

  5. Colafrancesco S, Alessandri C, Conti F. COVID-19 gone bad: A new character in the spectrum of hyperferritinemic syndrome?. Autoimun Rev. 2020; 19(7): 1025-1073. DOI: 10.1016/j.autrev.2020.102573.

  6. Lippi G, Plebani M, Henry BM. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a meta-analysis. Clin Chim Acta. 2020; 506: 145-148. DOI: 10.1016/j.cca.2020.03.022.

  7. Effenberger M, Grander C, Grabherr F, et al. Systemic in ammation as fuel for liver injury in COVID-19. Dig Liver Dis. 2021; 158-165. DOI: 10.1016/j.dld.2020.08.004.

  8. Li L, Li S, Xu M, et al. The level of plasma C-reactive protein is closely related to the liver injury in patients with COVID-19. Available from: medRxiv 2020. DOI: 10.1101/2020.02.28.20028514.

  9. Papadopoulos N, Vasileiadi S, Deutsch M. COVID-19 and liver injury: where do we stand? Ann Gastroenterol. 2020; 33: 459-464. DOI: 10.20524/aog.2020.0522.

  10. Cao J, Cai X, Chen M. Liver Injury in COVID-19: Caution and Management. Liver Cancer. 2020; 9: 625-626. DOI: 10.1159/000508696.

  11. Webb GJ, Marjot T, Cook JA, et al. Outcomes following SARS-CoV-2 infection in liver transplant recipients: an international registry study. Lancet Gastroenterol Hepatol. 2020; 5: 1008-1016. DOI: 10.1016/s2468-1253(20)30271-5.

  12. Chai X, Hu L, Zhang Y, et al. Speci c ACE2 expression in cholangiocytes may cause liver damage after 2019-nCoV infection. Available from: biorxiv 2020. DOI: 10.1101/2020.02.03.931766.

  13. Galanopoulos M, Gkeros F, Doukatas A, et al. COVID-19 pandemic: Pathophysiology and manifestations from the gastrointestinal tract. World J Gastroenterol. 2020; 26: 4579-4588. DOI: 10.3748/wjg.v26.i31.4579.

  14. Zhao B, Ni C, Gao R, et al. Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids. Protein Cell. 2020; 11: 771-775. DOI: 10.1007/s13238-020-00718-6.

  15. Rismanbaf A, Zarei S. Liver and kidney injuries in COVID-19 and their effects on drug therapy, a letter to editor. Arch Acad Emerg Med. 2020; 8: 17. PMID: 32185369; PMCID: PMC7075271.

 

UDC 617.7-001.3:001.33+617.7-079.6

DOI: 10.20969/VSKM.2022.15(6)34-39

PDF download THE SIGNIFICANCE OF CLASSIFICATIONS OF MECHANICAL INJURIES OF THE ORGANS OF VISION FOR SOLVING THE PROBLEMS OF FORENSIC MEDICAL EXAMINATION

INDIAMINOV SAYIT I., ORCID ID: 0000-0001-9361-085Х; D. Med. Sci., professor, Head of the Department of forensic medicine of Samarkand State Medical University of Republic of Uzbekistan, 140100, Samarkand, Amir Temur str., 18, e-mail: sayit.indiaminov@bk.ru

DAVRANOVA AZIZA E., ORCID ID: 0000-0002-3836-039Х; PhD, assistant professor of the Department of forensic medicine of Samarkand State Medical University of Republic of Uzbekistan, 140100, Samarkand, Amir Temur str., 18, e-mail: davranova1989@mail.ru

RASULOVA MUKHSINA R., ORCID ID: 0000-0002-8340-0741; PhD, associate professor of the Department of forensic medicine of Samarkand State Medical University of Republic of Uzbekistan, 140100, Samarkand, Amir Temur str., 18, e-mail: rmr-sme@mail.ru

Abstract. Introduction. The development of a uni ed classi cation of injuries of the organ of vision is necessary not only for clinicians, but it is also important for forensic medical experts, both for scienti c developments and for solving practical forensic problems, especially in cases of examination of injuries of mechanical origin to establish the severity of the harm caused to health. Aim. Aim is to identify the most rational classi cation of mechanical injuries of the organ of vision to solve the problems of forensic medical examination of damage to these structures. Material and methods.Studies were conducted on both clinical (150) and expert (178) materials. The main literature of recent years on the problem of injuries of the organ of vision is analyzed. Results and discussion. Currently, there is no uni ed classi cation of injuries of the organ of vision, covering all the clinical and morphological aspects of this problem. To solve forensic problems, the classi cations of injuries of the organ of vision (2002). In this case, the classi cation should take into account the nature, localization of damage to the external and internal structures of the eyes, as well as the presence of combined damage to adjacent anatomical structures – the head and orbit structure, as well as the zygomatic bone. The forensic medical quali cation of the severity of the harm caused to health also depends on the complications and long-term outcomes of injuries to the structures of the eyeball and its appendages. Conclusion. With penetrating wounds of the cornea, in most cases it leads to loss or a sharp decrease in vision. With non-penetrating wounds of the cornea, visual function is usually preserved. The main qualifying criteria for assessing the severity of these injuries are the duration of the health disorder and the amount of loss of stable general ability to work. There is a high risk of developing post-traumatic in ammatory processes, atrophy of the optic nerve and subatrophy of the eyeball. The criteria for qualifying the severity of bodily injuries for these groups of injuries are the amount of permanent loss of general ability to work or complete loss of vision.

Key words: organ of vision, trauma, classi cation, forensic medical examination, mechanism, severity.

For reference: Indiaminov SI, Davranova AE, Rasulova MR. The signi cance of classi cations of mechanical injuries of the organs of vision for solving the problems of forensic medical examination. The Bulletin of Contemporary Clinical Medicine. 2022; 15(6): 34-39. DOI: 10.20969/VSKM.2022.15(6).34-39.

References

  1. Гундорова Р.А., Степанов А.В., Курбанова Н.Ф. Современная офтальмотравматология. – Москва: Медицина, 2007. – 256 с. [Gundorova RA, Stepanov AV, Kurbanova NF. Sovremennaya oftalmotravmatologiya [Modern ophthalmotraumatology]. Moskva: Medicina [Moscow: The medicine]. 2007; 256 (In Russ.)]. URL: https://kingmed.info

  2. Гундорова Р.А., Кашников В.В. Повреждения глаз в чрезвычайных ситуациях: монография. – Новосибирск, 2002. – 5 с. [Gundorova RA, Kashnikov VV. Povrezhdeniya glaz v chrezvychaynykh situatsiyakh: monogra ya [Eye injuries in emergency situations: monograph]. Novosibirsk [Novosibirsk]. 2002; 5. (In Russ.)]. URL: https://search.rsl. ru/ru/record/01002373836

  3. Сидоренко Е.И. Офтальмология: учебник. – Москва: ГЭОТАР-Медиа, 2013. – 640 с. [Sidorenko EI, Ophthalmologiya: uchebnik [Ophthalmology: textbook] Moskwa. GEOTAR-Media [Moscow. GEOTAR-Media] 2013; 640. (In Russ.)]. URL: https://medknigaservis.ru/ wp-content/uploads

  4. Аветисов С.Э., Егоров Е.А., Мошетова Л.К. [и др.]. Офтальмология. Национальное руководство. – Москва, 2008. – 944 с. [Avetisov SE, Egorov EA, Moshetova LK, et al. Ophthalmologiya. Nationalnoe rukovodstvo [Ophthalmology. National Leadership]. Moskwa [Moscow] 2008; 944. (In Russ.)]. URL: https:// vk.com/wall-27885374_111056

  5. Аветисов С.Э., Егоров Е.А., Мошетова Л.К. [и др.]. Офтальмология. Национальное руководство. – Москва, 2019. – 752 с. [Avetisov SE, Egorov EA, Moshetova LK, et al. Ophthalmologiya. Nationalnoe rukovodstvo [Ophthalmology. National Leadership] Moskwa [Moscow] 2019; 752. (In Russ.)]. URL: https://medknigaservis.ru/wp-content/uploads/2019/05/NF0014052.pdf

  6. Ковалевская М.А., Максименков А.Т., Старикова М.А. Контузии глазного яблока при ДТП // Научно-медицинский вестник Центрального Черноземья. – 2018. – No 71. – С.64–71. [Kovalevskaya MA, Maksimenkov AT, Starikova MA. Kontuzii glaznogo yabloka pri DTP [Contusion of the eyeball in an accident.].Nauchno-meditsinskiy vestnik Sentralnogo Chernozemya [Scienti c and Medical Bulletin of the Central Chernozem Region] 2018; 71: 64-71. (In Russ.)]. URL: https://www.new.vestnik-surgery.com/index.php/1990-472X/article/view/16

  7. Волков В.В., Бойко Э.В., Шишкин М.М. [и др.]. Закрытая травма глаза (понятие, распространенность, эпидемиология, этиопатогенез, госпитализация, диагностика, классификация) // Офтальмохирургия. – 2005. – No 1. – С.13–17. [Volkov VV, Boyko EV, Shishkin MM, Saxonova EO, et al. Zakritaya travma glaza (ponyatie, rasprostranyonnost, epidemiologiya, etiopatogenez, gospitalizatsiya, diagnostika, klassifikatsiya) [Closed eye injury (concept, prevalence, epidemiology, etiopathogenesis, hospitalization, diagnosis, classification). Oftalmoxirurgiya [Ophthalmosurgery]. 2005; 1: 13-17. (In Russ.)]. URL: https://cdn.eyepress .ru/0001152/os2005n1.pdf

  8. Kuhn F, Morris R, Witherspoon CD, et al. Standardized classi cation of ocular trauma. Ophthalmology. 1996; 103: 240-243. DOI: 10.1016/s0161-6420(96)30710-0.

  9. Касымов Ф.О., Куликов В.С., Николаенко В.П., Зумбулидзе Н.Г. Механическая травма органа зрения: учебное пособие. – Санкт-Петербург: Издательство СЗГМУ им. И.И. Мечникова, 2015. – 51 с. [Kasymov FO, Kulikov VS, Nikolaenko VP, Zumbulidze NG. Mexanicheskaya travma organa zreniya [Mechanical trauma of the organ of vision] Uchebnoe posobie. Sankt-Peterburg Izdatelstno SZGMU im. I.I. Mechnikova [Textbook. St. Petersburg Publishing house SZGMU im. I.I. Mechnikov]. 2015; 51. (In Russ.)]. URL: https:// glazbook.ru/products/mekhanicheskaya-travma-organa-zreniya

  10. Волков В.В. Открытая травма глаза: монография. – Санкт-Петербург: ВМедА, 2016. – 280 с. [Volkov VV. Otritaya travma glaza [Open eye injury]. Monographiya [Monograph]. Sankt-Peterburg. VMedA [Sankt-Petersburg: VmedA] 2016; 280. (In Russ.)]. URL: https://ophthalmobook.com.ua/knigi/oftalmologiya/ diagnostika/otkryitaya-travma-glaza.html

  11. Гундорова Р.А., Астафьева Н.В., Конджария М. Клинические особенности контузионной (закрытой) травмы глаза при гипотоническом синдроме // Клиническая офтальмология. – 2006. – No 3. – С.107. [Gundorova RA, Astafieva NV, Konjaria M. Klinicheskiye osobennosti kontuzionnoy (zakritoy) travmi glaza pri gipotonicheskom syndrome [Clinical features of contusion (closed) eye injury in hypotonic syndrome] Klinicheskaya oftalmologiya [Clinical Ophthalmology] 2006; 3: 107. (In Russ.)]. URL: https://www.rmj.ru/articles/oftalmologiya/Klinicheskie_ osobennosti_kontuzionnoy_zakrytoy_travmy_glaza_pri_ gipotonicheskom_sindrome/

  12. Нероев В.В., Катаргина Л.А. Федеральные клинические рекомендации «Травма глаза закрытая» //Общероссийская общественная организация «Ассоциация врачей-офтальмологов» [Neroev VV, Katargina LA. Federalnie klinicheskiye rekomendatsii «Travma glaza zakritaya» [Federal clinical guidelines «Injury to the eye closed»] Obsherossiyskaya obshestvennaya organizatsiya «Assotsiatsiya vrachey-oftalmologov» [All-Russian public organization «Association of Ophthalmologists»]. 2017; 45-46. (In Russ.)]. URL: http://avo-portal.ru/documents/fkr/ztg.pdf

  13. Волков В.В. Судебно-медицинская экспертиза травмы глаза // Судебно-медицинская экспертиза. – 2010. – No 6. – С.42–43. [Volkov VV. Sudebno-meditsiskaya ekspertiza travmi glaza [Forensic medical examination of an eye injury] Sudebno-meditsiskaya ekspertiza [Forensic medical examination]. 2010; 6: 42-43. (In Russ.)]. URL: https://www.forens-med.ru/book.php?id=721

  14. Дячун К.В., Кузнецова Н.А., Семенов Д.А. Контузии глазного яблока // Актуальные проблемы офтальмологии. – 2013. – С.82. [Dyachun KV, Kuznetsova NA, Semenov DA. Kontuzii glaznogo yabloka [Contusion of the eyeball] Aktualniye problemi oftalmologii [Actual problems of ophthalmology]. 2013; 82. (In Russ.)]. URL: https:// eyepress.ru/article.aspx?12051

  15. Нормативные документы, регламентирующие судебномедицинскую экспертную деятельность в Республике Узбекистан. – Ташкент, 2012 (приложение 2 к приказу от 01.06.2012 No 153 министра здравоохранения Республики Узбекистан. С. 52). [Normativniye documenti reglamentiruyushiye sulebno-meditsinskuyu expertnuyu deyatelnost v Respublike Uzbekistan [Normative documents regulating forensic medical expert activities in the Republic of Uzbekistan] Тashkent [Tashkent] 2012 (prilojeniye 2 k prikazu ot 01.06.2012 No 153 ministra zdravooxraneniya Respubliki Uzbekistan). [Appendix No 2 to Order No 153 dated June 1, 2012. Minister of Health of the Republic of Uzbekistan]. 2012; 52. (In Russ.)].

 

UDC 796.012.12:796.332:575.174.015.3

DOI: 10.20969/VSKM.2022.15(6).40-43

PDF download ANALYSIS OF PHYSICAL PERFORMANCE OF FOOTBALL PLAYERS CONSIDERING POLYMORPHISM OF ENDURANCE GENES

KAYUMOV AZIZ I., ORCID ID: 0000-0002-6285-0110; assistant professor of the Department of gastroenterology and physiotherapy of Center for the development of professional qualifications of medical workers, Uzbekistan, 100077, Tashkent, M.Ulugbek district, Parkent str., 51, tel. +99-871-123-45-67, e-mail: qayumov-aziz@mail.com

KHAMRABAYEVA FERUZA I., ORCID ID: 0000-0002-4689-2986; D. Med. Sci., professor, the Head of the Department
of gastroenterology and physiotherapy of Center for the development of professional qualifications of medical workers, Uzbekistan, 100077, Tashkent, M.Ulugbek district, Parkent str., 51, tel. +99-871-123-45-67, e-mail: qayumov-aziz@mail.com

YUNUSOVA LALITA R., ORCID ID: 0000-0002-7807-9463; Ph.D, associate professor of the Department of oncology and medical radiology of Tashkent State Dental Institute, Uzbekistan, 100047, Tashkent, Yashnabad district, Tarakkiyot, str., 103, tel. +99-871-230-20-73, e-mail: lolita_yunusova@mail.ru

Abstract. Introduction. There are about 40 genes with polymorphisms associated with the development and manifestation of such human physical qualities as endurance, as well as functional characteristics and biochemical parameters that changing under the in uence of physical activities of different kinds. In addition to the «sports» genetic markers of endurance, there are also genetic markers of «trainable endurance» identi ed as a result of dynamic (longitudinal) studies, when the effect of training and its relationship with genotypes is analyzed. Aim. The current studyaimed to identify and analyze the polymorphism of three genes: angiotensin-converting enzyme, 1-alpha coactivator of the gamma receptor activated by peroxisome proliferators and angiotensin II type 1 receptor in young athletes involved in football. Material and methods. Samples of the buccal epithelium of 91 youth football teams of Tashkent were used as the material for the study. The analysis of gene polymorphism was carried out by polymerase chain reaction (PCR). Results and discussion. Our data suggest that the analysis of polygenic pro les of the examined young football players allowed us to identify genetically predisposed individuals to display the quality of «endurance» in them. Information about the genotype can be used by coaches to select promising athletes, choose an individual approach to training, correctly build the process of wellness classes and prevent the negative effect of excessive training effects that can lead to hypertrophy of the heart muscle. Conclusion. It should be noted that all the students we examined are genetically predisposed to playing football. A smaller number of individuals are likely to achieve a certain success and sportsmanship, since, in addition to genetic predisposition, favorable environmental factors are still necessary for this.

Key words: physical performance, football players, polymorphism of endurance genes, ACE, PPARGC1A, AT2R1

For reference: Kayumov AI, Khamrabayeva FI, Yunusova LR. Analysis of physical performance of football players considering polymorphism of endurance genes. The Bulletin of Contemporary Clinical Medicine. 2022; 15(6): 40-43.DOI: 10.20969/VSKM.2022.15(6).40-43.

References

  1. Ахметов И.И. Анализ комбинации генетических маркеров мышечной деятельности // Русский медицинский журнал. – 2011. – No 1 (спец. выпуск). – С. 6–11. [Ahmetov I.I. Analiz kombinacii geneticheskih markerov myshechnoj deyatel’nosti] [Analysis of the combination of genetic markers of muscle activity] Russkij medicinskij zhurnal [Russian Medical Journal]. 2011; 1: 6-11. (In Russ.)].

  2. Гейчук И.Н. Молекулярно-генетическое типирование полиморфизмов // Международный журнал прикладных и фундаментальных исследований. – 2016. – No 6-4. – С. 687–696. [Gejchuk I.N. Molekulyarno-geneticheskoe tipirovanie polimorfizmov] [Molecular genetic typing of polymorphisms] Mezhdunarodnyj zhurnal prikladnyh i fundamental’nyh issledovanij [International Journal of Applied and Fundamental Research]. 2016; (6-4): 687-696. (In Russ.)].

  3. Wolfarth B, Bray MS, Hagberg JM, Perusse L, et al. The human gene map for performance and health-related tness phenotypes: the 2004 update. Med. Sci. Sports Exerc. 2005; 37(6): 881-903. DOI: 10.1249/ mss.0b013e3181844179.

  4. Ahmetov II, Rogozkin VA. Genes, athlete status and training – An overview / In: Genetics and Sports / Edited by M. Collins. Basel, Karger, 2009. DOI: 10.1159/000235696.

  5. Bhambhani Y, Mactavish J, Warren S. Boosting in athletes with high-level spinal cord injury: knowledge, incidence and attitudes of athletes in paralympic sport. Disability and Rehabilitation. 2010; 32 (26): 2172-2190. DOI: 10.3109/09638288.2010.505678.

  6.  Chow JW, Levy СЕ. Wheelchair propulsion biomechanics and wheelers’ quality of life: an exploratory review. Disability and Rehabilitation: Assistive Technology. 2011; 6 (5): 365-377. DOI: 10.3109/17483107.2010.525290.

  7. Williams AG, Folland JP. Similarity of polygenic pro les limits the potential for elite human physical performance. J. Physiol. 2008; 586: 113-121. DOI: 10.1113/jphysiol. 2007.141887.

  8. Van der Woude LH, De Groot S, Janssen TW. Manual wheelchairs: research and innovation in rehabilitation, sports, daily life and health. Med Eng Phys. 2006; 28: 905-915. DOI: 10.1016/j.medengphy.2005.12.001.

  9. Levy CE, Chow JW. Pushrim-activated powerassist wheelchairs: elegance in motion. Am. J. Phys. Med. Rehabil. 2004; 83: 166-167. DOI: 10.1097/01. PHM.0000107500.89679.8E.

  10. Simpson RC, Lopresti EF, Cooper RA. How many people would bene t from a smart wheelchair? J. Rehabil. Res. 2008; 45: 53-72. DOI: 10.1682/jrrd.2007.01.0015.

 

UDC 616.1-008.8:577.125.8

DOI: 10.20969/VSKM.2022.15(6).44-49

PDF download CLINICAL CHARACTERISTICS OF PATIENTS WITH LIPID METABOLISM DISORDERS IN THE OUTPATIENT PRACTICE OF A LIPIDOLOGIST

KIM ZULFIYA F., ORCID ID: 0000-0003-4240-3329; C. Med. Sci., associate professor of the Department of internal medicine of Kazan State Medical University; deputy head physician on medical affairs of City Clinical Hospital No 7, Russia, Kazan, Chuykov str., 54; Chief freelance cardiologist of the Ministry of Health of Republic of Tatarstan, e-mail: profz@yandex.ru

GALYVICH ALBERT S., ORCID ID: 0000-0002-4510-6197; D. Med. Sci., professor, the Head of the Department of cardiology of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49; Chief freelance cardiologist of the Ministry of Health of the Russian Federation in the Volga Federal District, e-mail: agalyavich@mail.ru

SADYKOVA DINARA I., ORCID ID: 0000-0002-6662-3548; D. Med. Sci., the Head of the Department of hospital pediatrics of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49; Chief freelance pediatric specialist cardiologist of the Ministry of Health of the Russian Federation in the Volga Federal District and RT, e-mail: sadykovadi@mail.ru

SHCHERBAKOV STANISLAV YU., ORCID ID: 0000-0001-7417-2452; аssistant professor of the Department of anesthesiology and resuscitation, disaster medicine of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49; anesthesiologist-resuscitator of City Clinical Hospital No 7, Russia, Kazan, Chuykov str., 54, e-mail: vnim4nie@yandex.ru

NURIEVA LUIZA M., ORCID ID: 0000-0002-1762-9492; cardiologist of City Clinical Hospital No 7, Russia, Kazan, Chuykov str., 54, e-mail: nurievaluiza@list.ru

KIM EVGENY S., ORCID ID: 0000-0002-6997-6488; administrator of the Department cardiology No 1 of City Clinical Hospital No 7, Russia, Kazan, Chuykov str., 54, e-mail: evgenykim1996@gmail.com

Abstract. Introduction. In the Russian Federation, the general structure of morbidity is dominated by diseases of the circulatory system. The most common risk factor for the development of cardiovascular pathology are lipid metabolism disorders, and the most common cause of morbidity and mortality of patients is atherosclerosis. Aim. Assessment ofclinical, instrumental and laboratory characteristics of patients with lipid metabolism disorders who applied to the Adult Lipidology Center. Material and methods. We analyzed the causes and nature of lipid metabolism disorders in Adult Lipidology Center`s patients: 159 people aged 23–79 years [mean age (50,71±12,12) years]: 104 women (65,4%) and 55 men (34,6%). Methods of descriptive statistics were used for statistical processing of the research data. Results and discussion. There are 115 people of working age among patients (63,5% of women and 36,5% of men). Male patients were signi cantly younger than women (p<0,001) and they had higher average triglycerides (p=0,04). Causes for secondary dyslipidemia were identi ed in 23,27% of patients. Cardiovascular diseases were detected in 127 patients (79,87%). The most frequent cardiovascular diseases in male patients with the phenotype of a certain familial hypercholesterolemia were coronary artery disease (40%), atherosclerosis of the brachiocephalic arteries (22,73%), while in women hypertension (25%) and atheroscelerosis of the brachiocephalic arteries (8,16%). Conclusion. Themost common diseases are coronary heart disease, atherosclerosis of the brachiocephalic arteries and hypertension. In every fourth patient dyslipidemia has the characteristics of a secondary pathology (23,27%); from 4 to 6% of patients have the phenotype of familial hypercholesterolemia, the genotype of familial hypercholesterolemia was con rmed in 16,67% of cases.

Key words: lipid metabolism disorders, dyslipidemia, familial hypercholesterolemia, atherosclerosis.

For reference: Kim ZF, Galyvich AS, Sadykova DI, et al. Clinical characteristics of patients with lipid metabolism disorders in the outpatient practice of a lipidologist. The Bulletin of Contemporary Clinical Medicine. 2022; 15 (6): 44-49. DOI: 10.20969/VSKM.2022.15(6).44-49.

References

1. Ежов М.В., Близнюк С.А., Алексеева И.А. [и др.]. Распространенность гиперхолестеринемии и применение статинов в амбулаторной практике в Российской Федерации. Исследование АЙСБЕРГ – диагностирование пациентов с гиперхолестеринемией в условиях амбулаторной практики на раннем этапе с целью улучшения сердечно-сосудистого прогноза // Атеросклероз и дислипидемии. – 2017. – No 4. – С.5–18. [Ezhov MV, Bliznyuk SA, Alekseeva IA, et al. Rasprostranennost’ giperholesterinemii i primeneniya statinov v ambulatornoj praktike v Rossijskoj Federacii. Issledovanie AJSBERG – diagnostirovanie pacientov s giperholesterinemieJ v usloviyah ambulatornoj praktiki na rannem etape s cel’yu uluchsheniya serdechno-sosudistogo prognoza.] [Prevalence of hypercholesterolemia and use of statins in outpatient practice in the Russian Federation. The ICEBERG study is the diagnosis of patients with hypercholesterolemia in patients with ambulatory practice at an early stage in order to improve the cardiovascular prognosis] Ateroskleroz i dislipidemii [The Journal of Atherosclerosis and Dyslipidemias]. 2017; 4: 5-18. (In Russ.)].

2. Ежов М.В., Барбараш О.Л., Воевода М.И. [и др.]. Организация работы липидных центров в Российской Федерации – новые возможности // Российский кардиологический журнал. – 2021. – Т. 26, No 6. – С.44–89. [Ezhov MV, Barbarash OL, Voevoda MI, et al. Organizaciya raboty lipidnyh centrov v Rossijskoj Federacii – novye vozmozhnosti.[Organization of lipid centers operation in the Russian Federation – new opportunities] Rossijskij kardiologicheskij zhurnal [Russian Journal of Cardiology]. 2021; 26(6): 44-89. (In Russ.)]. DOI: 10.15829/1560-4071-2021-44-89.

3. Кухарчук В.В., Ежов М.В., Сергиенко И.В. [и др.]. Диагностика и коррекция нарушений липидного обмена с целью профилактики и лечения атеросклероза. Российские рекомендации, VII пересмотр // Атеросклероз и дислипидемии. – 2020. –Т. 1, No 38. – С.7–42. [Kukharchuk VV, Ezhov MV, Sergienko IV, et al. Ateroskleroz i dislipidemii. Diagnostika i korrekciya narushenij lipidnogo obmena s cel’yu profilaktiki i lecheniya ateroskleroza][Diagnostics and correction of lipid metabolism disorders in order to prevent and treat of atherosclerosis] Rossijskie rekomendacii, VII peresmotr [Russian recommendations VII revision]. 2020; 1(38): 7-42. (In Russ.)]. DOI: 10.34687/2219-8202.JAD.2020.01.0002.

4. Соколов А.А., Александрова О.Ю., Кашталап В.В. [и др.]. Методические рекомендации по организации медицинской помощи больным с наследственными атерогенными нарушениями липидного обмена в субъектах РФ // Атеросклероз и дислипидемии. – 2016. – No 4. – С.14–20 [Sokolov AA, Alexandrova OYu, Kashtalap VV, et al. Metodicheskie rekomendacii po organizacii medicinskoj pomoshchi bol’nym s nasledstvennymi aterogennymi narusheniyami lipidnogo obmena v sub”ektah RF][Methodical recommendations on the organization of medical care for patients with hereditary atherogenic disorders of lipid metabolism in the subjects of the Russian Federation] Ateroskleroz i dislipidemii [The Journal of Atherosclerosis and Dyslipidemias]. 2016; 4: 14-20. (In Russ.)].

5. Алиева А.С., Реутова О.В., Павлюк Е.И. [и др.]. Реализованные модели и перспективы управления нарушениями липидного обмена. Концепция центров по редким заболеваниям в липидологии // Российский кардиологический журнал. – 2021. –Т. 26, No 6. – С.45–38. [Alieva AS, Reutova OV, Pavlyuk EI, et al. Realizovannye modeli i perspektivy upravleniya narusheniyami lipidnogo obmena. Koncepciya centrov po redkim zabolevaniyam v lipidologii][ Realized models and prospects for the management of lipid metabolism disorders. The concept of centers for rare diseases in lipidology] Rossijskij kardiologicheskij zhurnal [Russian Journal of Cardiology]. 2021; 26(6): 45-38. (In Russ.)]. DOI:10.15829/1560-4071-2021-4538.

6. Садыкова Д.И., Зиатдинов А.И., Сенек С.А. [и др.]. Опыт организации медицинской помощи детям с нарушениями липидного обмена на примере работы Центра липидологии Детской республиканской клинической больницы в Республике Татарстан // Атеросклероз и дислипидемии. – 2021. – Т. 1, No 42. – С.52–58. [Sadykova DI, Ziatdinov AI, Senek SA, et al. Opyt organizacii medicinskoj pomoshchi detyam s narusheniyami lipidnogo obmena na primere raboty Centra lipidologii Detskoj respublikanskoj klinicheskoj bol’nicy v Respublike Tatarstan] [Experience in organizing medical care for children with lipid metabolism disorders on the example of the Lipidology Center of the Children’s Republican Clinical Hospital in the Republic of Tatarstan].. Ateroskleroz i dislipidemii [Atherosclerosis and dyslipidemia]. 2021; 1(42): 52-58. (In Russ.)]. DOI: 10.34687/2219-8202.JAD.2021.01.0005.

7. Ежов М.В., Бажан С.С., Ершова А.И. [и др.]. Клинические рекомендации по семейной гиепрхолестеринемии // Атеросклероз. – 2019. – Т. 15, No 1. – С.58–98. [Ezhov MV, Bazhan SS, Ershova AI, et al. Klinicheskie rekomendacii po semejnoj gieprholesterinemii] [Clinical guidelines for familial hepercholesterolemia] Ateroskleroz [Ateroscleroz]. 2019; 15(1): 58-98. (In Russ.)].

8. Mach F., Baigent C., L Catapano A., et al. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modi cation to reduce cardiovascular risk: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS), European Heart Journal. 2020; 41(1): 111-188. DOI: 10.1093/eurheartj/ehz455.

9. Карпов Ю.А., Кухарчук В.В., Бойцов С.А. Заключение совета экспертов Национального общества по изучению атеросклероза (НОА). Семейная гиперхолестеринемия в Российской Федерации: нерешенные проблемы диагностики и лечения // Атеросклероз и дислипидемии. – 2015. – No 2. – С.5–16. [Karpov YuA, Kukharchuk VV, Boytsov SA. Zaklyuchenie soveta ekspertov Nacional’nogo obshchestva po izucheniyu ateroskleroza (NOA). Semejnaya giperholesterinemiya v Rossijskoj Federacii: nereshennye problemy diagnostiki i lecheniya][Consensus Statement of the Russian National Atherosclerosis Society (RNAS) Familial hypercholesterolemia in Russia: outstanding issues in diagnosis and management] Ateroskleroz i dislipidemii [The Journal of Atherosclerosis and Dyslipidemias]. 2015; 2: 5-16. (In Russ.)].

10. Сергиенко И.В., Аншелес А.А. Выявление пациентов с семейной гиперхолестеринемией в российской популяции на примере Москвы и Московской области // Рациональная фармакотерапия в кардиологии. – 2018. – Т. 14, No 1. – С.77–87. [Sergienko IV, Ansheles AA. Vyyavlenie pacientov s semejnoj giperholesterinemiej v rossijskoj populyacii na primere Moskvy i Moskovskoj oblasti] [Identi cation of patients with familial hypercholesterolemia in the Russian population using the example of Moscow and the Moscow region] Racional’naya farmakoterapiya v kardiologii [Rational pharmacotherapy in cardiology] 2018; 14(1): 77-87. (In Russ.)]. DOI: 10.20996/1819-6446-2018-14-1-77-87.

11. Gerald FW, Samuel G, Anthony SW. Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation. Inter J Cardiol. 2014; 171: 309-325. DOI: 10.1016/j.ijcard.2013.11.025.

 

UDC 616-08-039.71-053.9:314.116(470.41) "2010/2020"

DOI: 10.20969/VSKM.2022.15(6).50-55

PDF download ANALYSIS AND ASSESSMENT OF HEALTH DEMOGRAPHIC PROCESSES OF PERSONS OVER WORKING AGE IN THE REPUBLIC OF TATARSTAN FOR 2010–2020

KITAEVA ENDZHE A., ORCID ID: 0000-0003-2147-9025; C. Med. Sci., assistant professor of the Department of general hygiene of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. +7-927-033-78-41, e-mail: kitaevaenge@mail.ru

GALIULLIN DAMIR A., ORCID ID: 0000-0002-8878-2777; C. Med. Sci., the Head of the medical department of nationwide charitable foundation «Yardem», Russia, 420006, Kazan, Yutazinskaya str., 8, tel. +7-917-291-72-14, e-mail: gvkim68@mail.ru

SHULAEV ALEKSEY V., ORCID ID: 0000-0002-2073-2538; D. Med. Sci., professor of the Department of general hygiene of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, e-mail: shulaev8@gmail.com

YUSUPOVA LUIZA А., ORCID ID: 0000-0002-4504-9700; D. Med. Sci., professor, the Head of the Department of dermatovenereology and cosmetology of Kazan State Medical Academy – the branch of the Russian Medical Academy of Continues Education, Russia, 420012, Kazan, Mushtary str., 11, tel. +7-843-238-69-16, e-mail: yuluizadoc@hotmail.com

KITAEV MANSUR R., ORCID ID: 0000-0001-7047-7996; C. Med. Sci., Chief Physician of the Children’s City Polyclinic No 6, Russia, 420087, Kazan, Otradnaya str., 38a, e-mail: mansurkitaev@mail.ru

GALIULLIN AFGAT N., ORCID ID: 0000-0002-1294-4055; D. Med. Sci., professor of the Department of general hygiene of the Training and Methodological Center «Lean Technologies in Health Care» of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. +7-987-296-87-64, e-mail: kybm@mail.ru

Abstract. Introduction. The article presents data from the analysis of medical and demographic processes in thehealth of the older population for 2010–2020 in the Republic of Tatarstan. Aim. The aim of the study is to formulateconcluding statements based on the analysis of medical and demographic health processes of people over working age for 2010–2020 in the Republic of Tatarstan. These ndings will be further studied in public health perspective and delivery of medical care for these people. Material and methods. The analysis of the population, mortality, disability, morbidity rates, life expectancy of people older than working age was carried out on the basis of of cial statistics for the period from 2010 to 2020 using the «Vital movement» table, materials of the State Autonomous Health Institution «Republican Information and Analytical Center» of the Ministry of Health of the Republic of Tatarstan, «Health and Health Statistics for 2010–2020». Results and discussion. The medical and statistical indicators of the demographicaging of the population of the Republic of Tatarstan are given. The article gives a characteristics of morbidity, mortality, disability, life expectancy, healthy life expectancy, as well as the prevalence of major socially signi cant diseases among people older than working age before the pandemic COVID-19 in the Republic of Tatarstan. Conclusion. The datapresented in the article are of practical importance in carrying out social and hygienic monitoring, predicting medical and demographic processes in the health of people older than working age, and using them in planning measures to protect public health.

Key words: medico-demographic processes, population size, disability, mortality, life expectancy, healthy life expectancy.For reference: Kitaeva EA, Galiullin DA, Shulaev AV, et al. Analysis and assessment of health demographic processes of persons over working age in the Republic of Tatarstan for 2010–2020. The Bulletin of Contemporary Clinical Medicine. 2022; 15 (6): 50-55. DOI: 10.20969/VSKM.2022.15(6).50-55.

References

1. Гринин В.М., Шестемирова Э.И. Демографическое старение в России на современном этапе // Вестник РАМН. – 2015. – Т. 70, No 3. – С.348–354. [Grinin VM, Shestemirova EI. Demogra cheskoye stareniye v Rossii na sovremennom etape [Demographic aging in Russia at the present stage]. Vestnik RAMN [Bulletin of the Russian Academy of Medical Sciences]. 2015; 70 (3): 348-354. (In Russ.)]. DOI: 10.15690/vramn.v70i3.1332.

2. Бурдаев Н.И., Сбоева С.Г., Кривошеев С.А. Анализ программ обеспечения активного долголетия лиц старшего возраста в Московском регионе //Сеченовский вестник. – 2019. – No 10 (2). – С.45. [Burdaev NI, Sboeva SG, Krivosheev SA. Analysis of programs for ensuring active longevity of senior citizens in the Moscow region [Analiz programm obespecheniya aktivnogo dolgoletii lits starshego aozrasta v Moskovskom regione]. Sechenovskiy vestnik [Sechenovsky Bulletin]. 2019; 10 (2): 45. (In Russ.)]. DOI: 10.26442/22187332.2019.2.45-53.

3. Галиуллин А.Н., Шамсияров Н.Н. Изучение медико-демографических процессов – основа развития стратегии здоровья // Фундаментальные исследования. – 2013. – No 12. – С.445–448 [Galiullin AN, Shamsiyarov NN. Izucheniye mediko-demogra cheskikh protsessov – osnova razvitiya strategii zdorov’ya [The study of medical and demographic processes is the basis for the development of a health strategy]. Fundamental’nyye issledovaniya [Fundamental Research]. 2013; 12: 445-448. (In Russ.)].

4. Чистякова Н.Е. Демографические проблемы сохранения и использования человеческого капитала населения старшего возраста // Экономика Северо-Запада: проблемы и перспективы развития. – 2017. – No 34. – С.139–150. [Chistyakova NE. Demogra cheskiye problemy sokhraneniya i ispol’zovaniya chelovecheskogo kapitala naseleniya starshego vozrasta [Demographic
problems of preservation and use of human capital of the older population]. Ekonomika Severo-Zapada: problemy i perspektivy razvitiya [Economics of the North-West: problems and development prospects]. 2017; 34: 139-150. (In Russ.)].

5. Галиуллин А.Н., Шамсияров Н.Н. Стратегия развития демографических процессов в мегаполисе // Фундаментальные исследования. – 2014. – No 2. – С.48–51. [Galiullin AN, Shamsiyarov NN. Strategiya razvitiya demogra cheskikh protsessov v megapolise [Strategy for the development of demographic processes in the metropolis]. Fundamental’nyye issledovaniya [Fundamental research]. 2014; 2: 48-51. (In Russ.)].

6. Корнилова М.В. Реализация государственной программы «Московское долголетие» как способ минимизации рисков пожилых // Общество: социология, психология, педагогика. – 2020. – No 9 (77). – С.25–30. [Kornilova MV. Realizatsiya gosudarstvennoy programmy «Moskovskoye dolgoletiye» kak sposob minimizatsii riskov pozhilykh [Implementation of the state program «Moscow longevity» as a way to minimize the risks of the elderly]. Society: sociology, psychology, pedagogy [Obshchestvo: sotsiologiya, psikhologiya, pedagogika]. 2020; 9 (77): 25-30. (In Russ.)]. DOI: 10.24158/spp.2020.9.3.

7. Комарова Л.Н. Проблемы качества жизни старших возрастных групп // Евразийское научное объединение. – 2017. – Т. 1, No 2. – С.70–72. [Komarova LN. Problemy kachestva zhizni starshikh vozrastnykh grupp [Problems of the quality of life of older age groups]. Yevraziyskoye nauchnoye obyedineniye [Eurasian Scienti c Association]. 2017; 1(2): 70-72. (In Russ.)]. DOI:10.23888/ HMJ20219144-50.

8. Щербакова Е.М. Старшее поколение населения России // Демоскоп Weekly. – 2019. – No 797/798. – С.1–20 [Shcherbakova EM. Starsheye pokoleniye naseleniya Rossii [The older generation of the population of Russia]. Demoskop Weekly [Demoscope Weekly]. 2019; 797/798: 1-20. (In Russ.)]. POP/DB/WPP/Rev.2017/SA2/POP/ F09-1.

9. Петросян А.Н., Шевчук Е.И., Кириллов П.Л. [и др.]. Состояние лиц старше трудоспособного возраста // Географические особенности старения населения России. – 2019. – No 6 (2). – С.55–83. [Petrosyan AN, Shevchuk EI, Kirillov PL, et al. Sostoyaniye lits starshe trudosposobnogo vozrasta [The state of persons older than working age]. Geogra cheskiye osobennosti stareniya naseleniya Rossii [Geographical features of the aging of the population of Russia]. 2019; 6 (2): 55-83. (In Russ.)].

10. Шляфер С.И. Заболеваемость населения старше трудоспособного возраста Российской Федерации // Современные проблемы здравоохранения медицинской статистики. – 2014. – No 1. – С.15–28. [Shlyafer SI. Zabolevayemost’ naseleniya starshe trudosposobnogo vozrasta Rossiyskoy Federatsii [The incidence of the population older than the working age of the Russian Federation]. Sovremennyye problemy zdravookhraneniya meditsinskoy statistiki [Modern problems of health care of medical statistics]. 2014; 1: 15-28. (In Russ.)].

11. Трубин В.В., Николаева Н.А., Павлеева Н.А. [и др.]. Пожилое население России: проблемы и перспективы // Социальный бюллетень. – 2016. – No 3. – 45 с. [Trubin VV, Nikolaeva NA, Pavleeva NA, et al. Pozhiloye naseleniye Rossii: problemy i perspektivy [The elderly population of Russia: problems and prospects]. Sotsial’naya byulleten’ [Social Bulletin]. 2016; 3: 45. (In Russ.)].

 

UDC 616-006.442-085.277.3-06:616.71-001.5+611.018.46-089.843

DOI: 10.20969/VSKM.2022.15(6).56-61

PDF download TRABECULAR BONE INDEX IN ASSESSING THE RISK OF LOW-ENERGY FRACTURES AFTER COURSES OF POLYCHEMOTHERAPY AND AUTOLOGOUS BONE MARROW TRANSPLANTATION

IN PATIENTS WITH HODGKIN’S LYMPHOMA

KITAEVA JULIA S., ORCID ID: 0000-0002-4092-6305; postgraduate student of the Department of internal medicine of State Scientific Center of the Russian Federation – Federal Medical Biophysical Center named after A.I. Burnazyan, Russia, 123098, Moscow, Zhivopisnaya str., 46, e-mail: JKhema@yandex.ru

PRASKURNICHY EVGENIY A., ORCID ID: 0000-0002-9523-5966; D. Med. Sci., professor, vice-rector for research and innovation of Medical and Biological University of Innovation and Continuing Education, the Head of the Department of internal medicine of State Scientific Center of the Russian Federation – Federal Medical Biophysical Center named after A.I. Burnazyan, Russia, 123098, Moscow, Zhivopisnaya str., 46, e-mail: praskurnichey@mail.ru

KONSTANTINOVA TATYANA S., ORCID ID: 0000-0003-4687-0784; C. Med. Sci., associate professor of the Department of propaedeutics of internal diseases of Ural State Medical University, Russia, 620014, Ekaterinburg, Repin str., 3, e-mail: kthema@yandex.ru

KUZNETSOVA ELENA V., ORCID: ID 0000-0002-1631-486X; C. Med. Sci., associate professor of the Department of propaedeutics of internal diseases of Ural State Medical University, Russia, 620014, Ekaterinburg, Repin str., 3, e-mail: aliska@k66.ru

Abstract. Introduction. Hodgkin’s lymphoma is one of the few hematologic diseases that is potentially treatable in the current health care setting. The use of cytostatic drugs, glucocorticosteroids, and the young age of disease debut are crucial factors in the development of osteoporosis in this group of patients. Aim. The aim of this work is to study the trabecular bone index to assess the risk of fractures in patients with Hodgkin’s lymphoma after standard polychemotherapy and polychemotherapy with autologous hematopoietic stem cell transplantation. Material and methods. In this study, patients with Hodgkin’s lymphoma were evaluated after courses of standard polychemotherapy and polychemotherapy with autologous hematopoietic stem cell transplantation. Results and discussion. In the studied groups, there was no decrease in bone mineral density below the age norm. In patients of the studied groups, the T-score in the lumbar spine is statistically signi cantly lower than in other areas of measurement. The values of bone mineral density and Z-criterion did not differ statistically signi cantly in the groups. In the groups of polychemotherapy and polychemotherapy with autologous hematopoietic stem cell transplantation, a low risk of fractures was noted in 26 (59%) patients and 25 (57%), respectively, intermediate – in 11 (25%) and 6 (14%) patients, respectively, high – in 7 (16%) and 13 (29%) patients, respectively. Thus, the trabecular bone index appeared to be more sensitive for assessing the risk of low-energy fractures in patients with Hodgkin’s lymphoma. The promise of using the trabecular bone index in the diagnosis of osteoporosis has been demonstrated in a number of clinical studies. In groups of patients with Hodgkin’s lymphoma, the risk of lowenergy fractures can be strati ed depending on the level of trabecular bone index. According to Russian and international clinical guidelines, all patients at risk of low-energy fractures should receive osteoporosis therapy. Conclusion. Theuse of the method of determining the trabecular bone index, as an addition to dual-energy absorptiometry, allows more accurate veri cation of the violation of the microarchitectonics of the bone tissue and assess the risk of low-energy fractures in this category of patients.

Key words: Hodgkin’s lymphoma, trabecular bone index, osteoporosis.

For reference: Kitaeva YS, Praskurnichy EA, Konstantinova TS, Kuznetsova EV. Trabecular bone index in assessing the risk of low-energy fractures after courses of polychemotherapy and autologous bone marrow transplantation in patients with Hodgkin’s lymphoma. The Bulletin of Contemporary Clinical Medicine. 2022; 15(6): 56-61.DOI: 10.20969/VSKM.2022.15(6).56-61.

References

1. Лесняк О.М. Аудит состояния проблемы остеопороза в странах Восточной Европы и Центральной Азии 2010 // Остеопороз и остеопатии. – 2011. – No 2. – С. 3–6. [Lesnyak OM. Audit sostoyaniya problemy osteoporoza v stranakh Vostochnoy Yevropy i Tsentral’noy Azii 2010] [Audit of the state of the problem of osteoporosis in Eastern Europe and Central Asia 2010]. Osteoporoz i osteopatii [Osteoporosis and osteopathies]. 2011; 2; 3-6. (In Russ.)].

2. Лесняк О.М., Баранова И.А., Белова К.Ю. [и др.]. Остеопороз в Российской Федерации: эпидемиология, медико-социальные и экономические аспекты проблемы (обзор литературы) // Травматология и ортопедия России. – 2018. – T. 1, No 24. – С. 155–168. [Lesnyak OM, Baranova IA, Belova KYu, et al. Osteoporoz v Rossiyskoy Federatsii: epidemiologiya, medikosotsial’nyye i ekonomicheskiye aspekty problemy (obzor literatury). [Osteoporosis in Russian Federation: Epidemiology, socio-medical and economical aspects (Review)]. Travmatologiya i ortopediya Rossii [Traumatology and Orthopedics in Russia]. 2018; 1 (24): 155-168. (In Russ.)].

3. Войтко М.С., Поспелова Т.И., Климонтов В.В., Файзуллина О.Н. Оценка минеральной плотности костной ткани у больных лимфомой Ходжкина // Сибирский научный медицинский журнал. – 2019. – Т. 1, No 39. – С. 43–49. [Voitko MS, Pospelova TI, Klimontov VV, Fayzullina ON. Otsenka mineral’noy plotnosti kostnoy tkani u bol’nykh limfomoy Khodzhkina. [Assessment of bone mineral density in patients with Hodgkin ́s lymphoma]. Sibirskiy nauchnyy meditsinskiy zhurnal [Siberian Scienti c Medical Journal]. 2019; 1 (39): 43-49. (In Russ.)]. DOI: http://dx.doi.org/10.15372/SSMJ20190106.

4. Демина Е.А. [и др.]. Общие принципы диагностики лимфом. Российские клинические рекомендации по диагностике и лечению злокачественных лимфопролиферативных заболеваний / под ред. И.В. Поддубной, В.Г. Савченко. – 2018. – С. 9–27. [Demina EA, et al. Obshchiye printsipy diagnostiki limfom. Rossiyskiye klinicheskiye rekomendatsii po diagnostike i lecheniyu zlokachestvennykh limfoproliferativnykh zabolevaniy. Pod red. I.V. Poddubnoy, V.G. Savchenko. [General principles for the diagnosis of lymphomas. Russian clinical guidelines for the diagnosis and treatment of malignant lymphoproliferative diseases. Pod red. I.V. Poddubnoi, V.G. Savchenko]. 2018; 9-27 (in Russ.)].

5. Pothuaud L, Carceller P, Hans D. Correlations between greylevel variations in 2D projection images (TBS) and 3D microarchitecture: applications in the study of human trabecular bone microarchitecture. Bone. 2008; 42(4): 775-787. DOI: 10.1016/j.bone.2007.11.018.

6. Silva BC, Leslie WD, Resch Н, et al. Trabecular bone score: a noninvasive analytical method based upon the DXA image. J. Bone Miner. Res. 2014; 29 (3): 518-530. DOI: 10.1002/jbmr.2176.

7. Muschitz C, Kocijan R, Haschka J, et al. TBS re ects trabecular microarchitecture in premenopausal women and men with idiopathic osteoporosis and low-traumatic fractures. Bone. 2015; 79: 259-266. DOI: 10.1016/j. bone.2015.06.007.

8. Гребенникова Т.А., Белая Ж.Е. Трабекулярный костный индекс для диагностики остеопороза при сахарном диабете 2-го типа: клинический случай // Остеопороз и остеопатии. – 2017. – Т. 20, No 1. – С. 22–27. [Grebennikova TA, Belaya ZhE. Trabekulyarnyy kostnyy indeks dlya diagnostiki osteoporoza pri sakharnom diabete 2 tipa: klinicheskiy sluchay. [Trabecular bone index for the diagnosis of osteoporosis in type 2 diabetes mellitus: a clinical case]. Osteoporoz i osteopatii [Osteoporosis and osteopathy]. 2017; 20 (1): 22-27. (In Russ.)].

9. Войтко М.С., Поспелова Т.И., Климонтов В.В. Проблема остеопороза у больных с распространенными стадиями лимфомы Ходжкина // Актуальные вопросы гематологии и трансфузиологии. – 2019. – С. 11–12. [Voitko MS, Pospelova TI, Klimontov VV. Problema osteoporoza u bol’nykh s rasprostranennymi stadiyami limfomy Khodzhkina. [The problem of osteoporosis in patients with advanced stages of Hodgkin’s lymphoma]. Aktual’nyye voprosy gematologii i transfuziologii [Topical issues of hematology and transfusiology]. 2019;11-12. (In Russ.)].

10. Цориев Т.Т., Белая Ж.Е., Мельниченко Г.А. Трабекулярный костный индекс – неинвазивный метод оценки качества костной ткани на основании рутинной двухэнергетической денситометрии. Перспективы использования в клинической практике // Альманах клинической медицины. – 2016. – Т. 44, No 4. – С. 462–476. [Tsoriev TT, Belaya ZE, Mel’nichenko GA. [Trabekulyarnyy kostnyy indeks – neinvazivnyy metod otsenki kachestva kostnoy tkani na osnovanii rutinnoy dvukhenergeticheskoy densitometrii. Perspektivy ispol’zovaniya v klinicheskoy praktike] [Trabecular Bone Score – A non-Invasive Analytical Method to Evaluate Bone Quality Based on Routine Dual-Energy Absorptiometry. Perspectives of Its Use in Clinical Practice]. Al’manakh Klinicheskoy Meditsiny [Almanac of Clinical Medicine]. 2016; 44 (4): 462-476. (In Russ.)]. DOI: 10.18786/2072-0505-2016-44-4-462-476.

11. Hans D, Barthe N, Boutroy S, et al. Correlations Between Trabecular Bone Score, Measured Using Anteroposterior Dual-Energy X-Ray Absorptiometry Acquisition, and 3-Dimensional Parameters of Bone Microarchitecture: An Experimental Study on Human Cadaver Vertebrae. J. Clin. Densitom. 2011; 14 (3): 302-312.

 

UDC 616.587-007.24-089

DOI: 10.20969/VSKM.2022.15(6).62-71

PDF download METHOD OF SURGICAL TREATMENT OF HAMMER TOE WITH HALLUX VALGUS

KOSAREVA MARIYA A., ORCID ID: 0000-0003-0530-3409; junior researcher of Irkutsk Science Centre of Surgery
and Traumatology, Russia, 664003, Irkutsk, Bortsov Revolyucii str., 1, tel. 8-395-229-03-44, e-mail: mary.good.mary@yandex.ru

LEONOVA SVETLANA N., ORCID ID: 0000-0003-3675-6355; D. Med. Sci., senior researcher of Irkutsk Science Centre of Surgery and Traumatology, Russia, 664003, Irkutsk, Bortsov Revolyucii str., 1, tel. 8-395-229-03-44, e-mail: svetlana.leonova.1963@mail.ru

USOLTSEV IVAN V., ORCID ID: 0000-0002-4175-8403; C. Med. Sci., researcher of Irkutsk Science Centre of Surgery and Traumatology, Russia, 664003, Irkutsk, Bortsov Revolyucii str., 1, tel. 8-395-229-03-44, e-mail: ivu38@mail.ru

Abstract. Introduction. The results of treatment of patients with hammer-toe deformity of the small toes associated with hallux valgus were analyzed. Disadvantages and complications of known methods of treatment are revealed. A new pathogenetic method was proposed, including the sequential execution of two osteotomies. Aim. To evaluate the effectiveness of the proposed method of surgical treatment of patients with hammer-toe deformity associated with hallux valgus. Material and methods. The proposed method of hammer-toe surgical treatment includes two osteotomies: diaphyseal osteotomy of the metatarsal bone and osteotomy of the proximal phalanx of the nger. The angle of open-wedge proximal phalanx osteotomy is equal to the angle of the residual rear deviation of the toe. Placement of the formed auto- or allo- bone grafts in the space of open-wedge proximal phalanx osteotomy. 36 patients were operated with this method. The effectiveness of this method was evaluated by comparative analysis with a group of 40 patientsoperated on by the Helal osteotomy. Results and discussion. The proposed method made it possible to eliminate the hammer-toe deformity of the second toe, signi cantly reduce the number of cases of residual rear deviation and signi cantly improve the functional result, eliminate hyperkeratosis on the foot, increase patient satisfaction. The values of the achieved correction of the rear deviation of the second nger in the metatarsophalangeal joint were determined, de ning the repositionable capabilities of surgical methods equal to (40,17±2,32) degrees when using the proposed method, and (18,70± 3,27) degrees when performing osteotomy according to Helal osteotomy. Conclusion. The use ofthe proposed method of surgical treatment of patients with hammer-toe deformity associated with hallux valgus allows to increase the effectiveness of treatment, achieve permanent correction of deformation and correction of excessive dorsal deviation of the small toe in the metatarsophalangeal joint, improve the appearance of the foot, anatomical and functional result, reduce the risk of residual deformation in the form of a dorsal deviation of the nger.

Key words: hallux valgus, hammer-toe deformity, metatarsal osteotomy, osteotomy of the proximal phalanx of the nger.

For reference: Kosareva MA, Leonova SN, Usoltsev IV. Method of surgical treatment of hammer toe with hallux valgus. The Bulletin of Contemporary Clinical Medicine. 2022; 15(6): 62-71. DOI: 10.20969/VSKM.2022.15(6).62-71.

References

1. Angirasa AK, Barrett MJ, Silvester D. Smart. Toe implant compared with Kirschner wire fixation for hammer digit corrective surgery: areview of 28 patients. J Foot Ankle Surg. 2012; 51(6): 711-713. DOI:10.1053/j. jfas.2012.06.013.

2. Miller DJ, Throckmorton TW, Azar FM, et al. Business and practice management knowledge deficiencies in graduating orthopedic residents. Am J Orthop (Belle Mead NJ). 2015; 44 (10): E373-378.

3. Canales MB, Razzante MC, Ehredt DJ, Clougherty CO. A simple method of intramedullary xation for proximal interphalangeal arthrodesis. J Foot Ankle Surg. 2014; 53(6): 817-824. DOI: 10.1053/j.jfas.2014.03.017.

4. Coughlin MJ. Lesser toe deformities. In: Coughlin MJSC, Anderson RB, eds. Mann’s surgery of the foot and ankle. Ninth ed. Elsevier. 2014: 322-424.

5. Косарева М.А., Леонова С.Н. Проблемы хирургического лечения молоткообразной деформации пальцев стопы (обзор литературы) // Acta Biomedica Scientifica. – 2020. – Т. 5, No 6. – С. 235–242. [Kosareva MA, Leonova SN. Problemy hirurgicheskogo lecheniya molotkoobraznoj deformacii pal’cev stopy (obzor literatury) [Problems of Surgical Treatment of Hammer Toes (Review of Literature)]. Acta Biomedica Scienti ca. [Acta Biomedica Scienti ca] 2020; 5(6): 235-242. (In Russ.)]. DOI: 10.29413/ABS.2020-5.6.30.

6. Способ хирургического восстановления плантарной пластинки малого плюснефалангового сустава прямым подошвенным доступом при травматических разрывах ее вследствие перегрузочной метатарзалгии: пат. 2673382(13)C1, Рос. Федерация, МПК А61В 17/56 / А.Н. Блаженко, В.Н. Черевцов, А.А. Тадж, В.Г. Процко, Н.В. Загородний; заявитель и патентообладатель Процко Виктор Геннадьевич. No 2018126338; заявл. 2018.07.17; опубл. 2018.11.26, Бюл. No 33. [Sposob hirurgicheskogo vosstanovleniya plantarnoj plastinki malogo plyusnefalangovogo sustava pryamym podoshvennym dostupom pri travmaticheskih razryvah ee vsledstvie peregruzochnoj metatarzalgii: pat. 2673382(13) C1. [A method of surgical restoration of the planetary plate of the small metatarsophalangeal joint by direct plantar access in case of traumatic ruptures due to overload metatarsalgia: pat. 2673382(13)C1]. Ros. Federaciya [Rus. Federation], MPK A61V 17/56 / AN Blazhenko, VN Cherevcov, AA Tadzh, VG Procko, NV Zagorodnij; zayavitel’ i patentoobladatel’ Procko Viktor Gennad’evich. [the applicant and the patent holder Procko Viktor Gennad’evich]. No 2018126338; zayavl. 2018.07.17; opubl. 2018.11.26, Byul. No 33.[ Bulletin No 33] (in Russ.)].

7. Stainsby GD. Pathological anatomy and dynamic effectof the displaced plantar plate and the importance of theintegrity of the plantar plate-deep transverse metatarsal ligament tie-bar. Ann R Coll Surg Engl. 1997; 79(1): 58-68.

8. Кузьмина Ю.О. Выбор метода хирургической коррекции молоткообразной деформации пальцев стоп: диссертация на соискание ученой степени кандидата медицинских наук: 14.00.22 / Кузьмина Юлия Олеговна. – Москва, 2009. – 92 c. [Kuz’mina, YuO. Vybor metoda hirurgicheskoj korrekcii molotkoobraznoj deformacii pal’cev stop: dis. kand. med. nauk: 14.00.22. [The choice of the method of surgical correction of hammer-shaped deformity of the toes: dis. Candidate of Medical Sciences: 14.00.22. Moscow, 2009: 92. (in Russ.)].

9. Kirby KA. Foot and Lower Extremity Biomechanics IV: Precision Intricast Newsletters, 2009-2013. Precision Intricast, Inc., Payson, AZ, 2014: 89-90. DOI:10.7547/0990476.

10. Черкес-Заде Д.И., Каменев Ю.Ф. Хирургия стопы. – 2-е изд., перераб. и доп. – Москва: Медицина, 2002. – 328 с.: ил. [Cherkes-Zade D.I., Kamenev Yu.F. Hirurgiya stopy. Izd. 2-e, pererab. i dop. Moscow: Medicina [Foot surgery. 2nd ed., reprint. and additional. – Moscow: Medicine]. 2002: 328. (in Russ.)].

11. Тадж А.А., Процко В.Г., Черевцов В.Н., Волков А.В. Сравнение результатов Хелал и Вейль остеотомии для лечения метатарзалгии при вторичном вывихе в плюснефаланговых суставах I, III и IV плюсневых костей // Дневник казанской медицинской школы. – 2017. – Т III (XVII). – С.54–61. [Tadzh AA, Procko VG, Cherevcov VN, Volkov AV. Sravnenie rezul’tatov Helal i Vejl’ osteotomii dlya lecheniya metatarzalgii pri vtorichnom vyvihe v plyusnefalangovyh sustavah 2, 3 i 4 plyusnevyh kostej. [Comparison of the results of Helal and Weil osteotomy for the treatment of metatarsalgia with secondary dislocation in the metatarsophalangeal joints of the 2nd, 3rd and 4th metatarsal bones.] Dnevnik Kazanskoj medicinskoj shkoly. [Diary of the Kazan Medical School]. 2017; III (XVII): 54-61 (in Russ.)].

12. Бобров Д.С., Шубкина А.А., Лычагин А.В. [и др.]. Хирургическое лечение молоткообразной деформации пальцев стоп (обзор литературы) // Вестник РАМН. – 2019. – Т. 74, No 4. – С. 272–282. [Bobrov DS, Shubkina AA, Lychagin AV, et al. Hirurgicheskoe lechenie molotkoobraznoj deformacii pal’cev stop (obzor literatury). [Surgical treatment of hammertoes (literature review)]. Vestnik RAMN. [Annals of the Russian academy of medical sciences]. 2019; 74(4): 272-282. (In Russ.)] DOI:10.15690/ vramn1096.

13. Trnka HJ, et al. Comparison of the results of the Weil and Helal osteotomies for the treatment of metatarsalgiasecondary to dislocation of the lesser metatarsophalangealjoints. Foot Ankle Int. 1999 Feb; 20(2): 72-79.

14. Migues A, Slullitel G, Bilbao F, et al. Floating-toe deformity as a complication of the Weil osteotomy. Foot Ankle Int. 2004; 25(9): 609-613. DOI: 10.1177/107110070402500902.

15. Черевцов В.Н., Тадж А.А., Процко В.Г., Тамоев С.К. Лечение синдрома центральной метатарзалгии // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и технические науки. – 2017. – No 7/8. – С. 139–144. [Cherevcov VN, Tadzh AA, Procko VG, Tamoev SK. Lechenie sindroma central’noj metatarzalgii. [Treatment of central metatarsalgia syndrome.] Sovremennaya nauka: aktual’nye problemy teorii i praktiki. Seriya: Estestvennye i Tekhnicheskie Nauki. [Modern science: actual problems of theory and practice. Series: Natural and Technical Sciences]. 2017; 7/8: 139-144. (In Russ.)].

16. Highlander P, VonHerbulis E, Gonzalez A, et al. Complications of the Weil osteotomy. Foot Ankle Spec. 2011; 4(3): 165-170. DOI :10.1177/1938640011402822.

17. Coughlin MJ, Dorris J, Polk E. Operative repair of the xed hammertoe deformity. Foot Ankle Int. 2000; 21(2): 94-104. DOI: 10.1177/107110070002100202.

18. Бобров Д.С., Шубкина А.А., Лычагин А.В., Слиняков Л.Ю. [и др.]. Результаты хирургического лечения перегрузочной метатарзалгии с использованием минимально инвазивных методик // Кафедра травматологии и ортопедии. – 2018. – No 4 (34). – С. 7–15. [Bobrov DS, Shubkina A, Lychagin AV, et al. Rezul’taty hirurgicheskogo lecheniya peregruzochnoj metatarzalgii s ispol’zovaniem minimal’no invazivnyh metodik. [Outcome surgical treatment of metatarsalgia using minimally invasive techniques]. Kafedra travmatologii i ortopedii.[Department of Traumatology and Orthopedics]. 2018; 4(34):7-15. (In Russ.)]. DOI: 10.17238/issn2226-2016.2018.4.7-15.

19. Albright RH, Hassan M, Randich J, et al. Risk Factors for Failure in Hammertoe Surgery. Foot Ankle Int. 2020; 41(5): 562-571. DOI: 10.1177/1071100720904931.

20. Thompson FM, Hamilton WG. Problems of the second metatarsophalangeal joint. Orthopedics. 1987; 10(1): 83-89.

21. Леонова С.Н., Усольцев И.В. Способ оперативного лечения вальгусного отклонения первого пальца стопы: медицинская технология. – Иркутск: ИНЦХТ, 2016. – 20 с. [Leonova SN, Usol’cev IV. Sposob operativnogo lecheniya val’gusnogo otkloneniya pervogo pal’ca stopy: medicinskaya tekhnologiya. [Method of surgical treatment of valgus deviation of the rst toe Method of surgical treatment of valgus deviation of the rst toe: medical technology]. Irkutsk: INCHT [Irkutsk: INCHT]. 2016; 20 (In Russ.)].

22. Способ исправления тыльного отклонения малого пальца стопы: пат. 2773681 С1, Рос. Федерация, МПК А61В 17/56 / И.В. Усольцев, С.Н. Леонова, М.А. Косарева; заявитель и патентообладатель ИНЦХТ. – No 2021120801; заявл. 2021.07.13; опубл. 2022.06.07. Бюл. No 16. [Sposob ispravleniya tyl’nogo otkloneniya malogo pal’ca stopy: pat. 2773681 S1. [Method of correction of the back deviation of the small toe: pat. 2773681 C1 Method of correction of the back deviation of the small toe: pat. 2773681 C1.] Ros. Federaciya. [Rus. Federation] MPK A61V 17/56 / IV Usol’cev, SN Leonova, MA Kosareva; zayavitel’ i patentoobladatel’ INCHT. [The applicant and the patent holder INCHT] No 2021120801; zayavl. 2021.07.13; opubl. 2022.06.07. Byul. No 16. [Bulletin No 16] (In Russ.)].

23. Helal B.: Metatarsal osteotomy for metatarsalgla. J. Bone Joint Surg., 57B: 187-192, 1975.

24. Kelikian H. Hallux Valgus, Allied Deformities of the Forefoot and Metatarsalgia. Philadelphia, London: W.B. Saunders Corp., 1965: 503.

 

UDC 616.711.1-001-06:616.832-001.35+616.8-009.1:617.57

DOI: 10.20969/VSKM.2022.15 (6).72-77

PDF download ASSESSMENT OF DEXTERITY OF HANDS IN PATIENTS AFTER DECOMPRESSION AND VENTRAL SUBAXIAL FUSION

OSOLODCHENKO LEONID V., ORCID ID: 0000-0002-4256-6622; C. Med. Sci., the Head of the Department of neurosurgery of Lipetsk Regional Clinical Hospital, Russia, 398055, Lipetsk, Moskovskaya str., 6a, e-mail: leoniddoctor@bk.ru

TRAVKOV DMITRY A., ORCID ID: 0000-0003-4457-3911; neurosurgeon of Lipetsk Regional Clinical Hospital, Russia, 398055, Lipetsk, Moskovskaya str., 6a, e-mail: docdat@ro.ru

VERESHCHAKO ANATOLY V., ORCID ID: 0000-0002-9636-5316; D. Med. Sci., professor of the Department of neurosurgery of North-Western State Medical University named after I.I. Mechnikov, Russia, 192242, St. Petersburg, Budapeshskaya str., 3, e-mail: vereshako@inbox.ru

KOSYGIN VLADISLAV S., ORCID ID: 0000-0002-9148-2214; neurosurgeon of Lipetsk Regional Clinical Hospital, Russia, 398055, Lipetsk, Moskovskaya str., 6a, e-mail: vlkosigin@yandex.ru

POMERANTSEV ANDREY A., ORCID ID: 0000-0003-4197-2183; C. Ped. Sci., associate professor of the Department of physical culture, physiology and biomedical disciplines of Lipetsk State Pedagogical University named after P.P. Semenov-Tyan-Shansky, Russia, 398020, Lipetsk, Lenin str., 42, tel. 8-904-297-66-13, e-mail: a.pomerantsev.1981@gmail.com

STARKIN ALEXANDER N., ORCID ID: 0000-0002-5842-2981; C. Ped. Sci., associate professor of the Department of physical culture, physiology and biomedical disciplines of Lipetsk State Pedagogical University named after P.P. Semenov-Tyan-Shansky, Russia, 398020, Lipetsk, Lenin str., 42, tel. 8-960-148-66-65, e-mail: starkin.an@mail.ru

Abstract. Aim. Improving the long-term results of surgical treatment requires not only timely diagnosis, but also self-monitoring of the dynamics of impaired functions on the part of the patient. The aim of the study was to establish the reliability of the test by comparing its results with clinical data and information from electroneuromyography of the upper extremities in patients after decompression-ventral subaxial fusion. Material and methods. The presence of motordisorders reduction or loss of bicipital, tricipital and carporadial re exes and electroneuromyography data was compared with the results of the method according to patent RU2717365C1 in 27 patients after decompression-ventral subaxial cervicospondylodesis due to diseases and injuries of the cervical spine. Results and discussion. It was found that the test was slowed down in patients with motor de ciency of the upper extremities with a corresponding level of damage to the performed reverse gesture. The same pattern with respect to the decrease or absence of appropriate re exes, as well as the slowing down of the motor spine system according to the electroneuromyography. Conclusions. The testis quite sensitive and objective, can be recommended to patients for self-control. The use of this method for patients does not cancel the need for planned diagnostic measures and does not replace them. The development of such tests can help improve the selection of rehabilitation measures.

Key words: ventral subaxial cervical fusion, dexterity of the hands.

For reference: Osolodchenko LV, Travkov DA, Vereshchako AV, et al. Assessment of dexterity of hands in patients after decompression and ventral subaxial fusion. The Bulletin of Contemporary Clinical Medicine. 2022; 15(6): 72-77.DOI: 10.20969/VSKM.2022.15(6).72-77.

References

1. Tasiou A, Giannis T, Brotis AG, et al. Anterior cervical spine surgery-associated complications in a retrospective case-control study. J Spine Surg. 2017; 3(3): 444-459. DOI: 10.21037/jss.2017.08.03.

2. He J, Wu T, Ding C, Wang B, Hong Y, Liu H. Bibliometric and visualized analysis of the top 100 most-cited articles on anterior cervical surgery. EFORT Open Rev. 2021; 6(12): 1203-1213. DOI:10.1302/2058-5241.6.210074.

3. Cheung JP, Luk KD. Complications of Anterior and Posterior Cervical Spine Surgery. Asian Spine J. 2016; 10(2): 385-400. DOI: 10.4184/asj.2016.10.2.385.

4. Нехлопочин А.С., Мироненко Т.В., Нехлопочин С.Н. Динамика интенсивности болевого синдрома у пациентов, перенесших передний субаксиальный спондилодез // Нервные болезни. – 2018. – No 2. – С. 32–37. [Nehlopochin AS, Mironenko TV, Nehlopochin SN. Dinamika intensivnosti bolevogo sindroma u pacientov, perenesshih perednij subaksial’nyj spondilodez [Dynamic of Pain Intensity in Patients after Anterior Subaxial Cervical Spinal Fusion]. Nervnye bolezni [Nervous Diseases]. 2018; 2: 32-37. (In Russ.)]. DOI:10.24411/2226-0757-2018-12020.

5. Слынько Е.И., Нехлопочин А.С. Качество жизни пациентов после вентрального субаксиального цервикоспондилодеза в отдаленном послеоперационном периоде // Травма. – 2019. – Т. 20, No 2. – С. 88–95. [Slyn’ko EI, Nehlopochin AS. Kachestvo zhizni pacientov posle ventral’nogo subaksial’nogo cervikospondilodeza v otdalennom posleoperacionnom periode [Quality of life of patients after ventral subaxial cervicospondylodesis in the long-term postoperative period]. Travma [Trauma]. 2019; 20(2): 88-95. (In Russ.)]. DOI 10.22141/1608-1706.2.20.2019.168025.

6. Cole TS, Almefty KK, Godzik J, et al. Functional improvement in hand strength and dexterity after surgical treatment of cervical spondylotic myelopathy: a prospective quantitative study. J Neurosurg Spine. 2020 Feb; 7:1-7. DOI: 10.3171/2019.10.SPINE19685.

7. Omori M, Shibuya S, Nakajima T, et al. Hand Dexterity Impairment in Patients with Cervical Myelopathy: A New Quantitative Assessment Using a Natural Prehension Movement. Behav Neurol. 2018; 2: 5138234. Published 2018 Jul 4. DOI:10.1155/2018/5138234.

8. Burr P, Choudhury P. Fine Motor Disability. StatPearls [Internet]. Treasure Island (FL). 2021, Jan. https://www.ncbi. nlm.nih.gov/books/NBK563266 [Updated 2021 Aug 11].

9. Smith ZA, Barry AJ, Paliwal M, et al. Assessing hand dysfunction in cervical spondylotic myelopathy. PloS one. 2019; 14(10): e0223009. URL: https://doi.org/10.1371/ journal.pone.0223009

10. Meiners T, Abel R, Lindel K, et al. Improvements in activities of daily living following functional hand surgery for treatment of lesions to the cervical spinal cord: selfassessment by patients. Spinal cord. 2002; 40(11): 574-580.

11. Li R, Huang ZC, Cui HY, et al. Utility of somatosensory and motor-evoked potentials in re ecting gross and ne motor functions after cervical spinal cord contusion injury. Neural regeneration research. 2021; 16(7): 1323-1330. URL: https://doi.org/10.4103/1673-5374.301486

12. Минниахметова Л.А., Тахаутдинов Р.Р. Клинико-физиологическое обоснование и основные механизмы лечебного действия физических упражнений // Проблемы и перспективы развития образования в России. – 2014. – No 31. – С.137–141. [Minniahmetova LA, Tahautdinov RR. Kliniko-ziologicheskoe obosnovanie i osnovnye mehanizmy lechebnogo dejstvija zicheskih uprazhnenij [Clinical and physiological justi cation and the main mechanisms of the therapeutic effect of physicalexercises]. Problemy i perspektivy razvitija obrazovanija v Rossii [Problems and prospects of education development in Russia]. 2014; 31: 137-141. (In Russ.)].

13. Higo N. Effects of rehabilitative training on recovery of hand motor function: a review of animal studies. Neurosci Res. 2014 Jan; 78: 9-15. DOI: 10.1016/j.neures.2013.09.008/

14. Sandrow-Feinberg HR, Izzi J, Shumsky JS, et al. Forced exercise as a rehabilitation strategy after unilateral cervical spinal cord contusion injury. J Neurotrauma. 2009; 26(5): 721-731. DOI: 10.1089/neu.2008.0750.

15. Tederko P, Krasuski M, Tarnacka B. Effectiveness of rehabilitation after cervical disk surgery: a systematic review of controlled studies. Clin Rehabil. 2019; 33(3): 370-380. DOI:10.1177/0269215518810777.

16. McFarland C, Wang-Price S, Gordon CR, et al. Comparison of Clinical Outcomes between Early Cervical Spine Stabilizer Training and Usual Care in Individuals following Anterior Cervical Discectomy and Fusion. Rehabil Res Pract. 2020; 2020: 5946152. DOI: 10.1155/2020/5946152.

17. Peolsson A, Peterson G, Hermansen A, et al. Physiotherapy after anterior cervical spine surgery for cervical disc disease: study protocol of a prospective randomised study to compare internet-based neck-speci c exercise with prescribed physical activity. BMJ open. 2019; 9(2): e027387. DOI: 10.1136/bmjopen-2018-027387.

18. Swanson BT, Leger RR. Physical therapy following anterior cervical discectomy and fusion: a study of current clinical practice and therapist beliefs. International Journal of Physiotherapy. 2015; 2(2): 399-406. DOI: 10.15621/ ijphy/2015/v2i2/65249.

19. Peolsson A, Öberg B, Wibault J, et al. Outcome of physiotherapy after surgery for cervical disc disease: a prospective randomised multi-centre trial. BMC Musculoskelet Disord. 2014; 15: 34. DOI:10.1186/1471-2474-15-34.

20. Wibault J, Öberg B, Dedering Å, et al. Structured postoperative physiotherapy in patients with cervical radiculopathy: 6-month outcomes of a randomized clinical trial. Journal of neurosurgery. Spine. 2018; 28(1): 1-9. DOI: 10.3171/2017.5.SPINE16736.

21. Бут-Гусаим В.В., Ярош А.С. Методы оценки мелкой моторики и силы кисти у пациентов с центральными и периферическими парезами, возможности их использования // Журнал Гродненского государственного медицинского университета. – 2017. – Т. 15, No 3. – С.356–359. [But-Gusaim VV. Jarosh AS. Metody ocenki melkoj motoriki i sily kisti u pacientov s central’nymi i perifericheskimi parezami, vozmozhnosti ih ispol’zovanija [Methods for assessing fine motor skills and hand strength in patients with central and peripheral paresis, the possibility of their use]. Zhurnal Grodnenskogo gosudarstvennogo medicinskogo universiteta [Journal of the Grodno State Medical University]. 2017; 15(3): 356-359. (In Russ.)]. DOI 10.25298/2221-8785-2017-15-3-356-359.

22. Grasse KM, Hays SA, Rahebi KC, et al. A suite of automated tools to quantify hand and wrist motor function after cervical spinal cord injury. J Neuroeng Rehabil. 2019; 16(1): 48. DOI:10.1186/s12984-019-0518-8.

23. Yancosek KE, Howell D. A narrative review of dexterity assessments. J Hand Ther. 2009; 22(3): 258-270. DOI: 10.1016/j.jht.2008.11.004.

24. Térémetz M, Colle F, Hamdoun S, et al. A novel method for the quanti cation of key components of manual dexterity after stroke. J Neuroeng Rehabil. 2015; 12: 64. Published 2015 Aug 2. DOI:10.1186/s12984-015-0054-0.

25. Proud EL, Bilney B, Miller KJ, et al. Measuring Hand Dexterity in People With Parkinson’s Disease: Reliability of Pegboard Tests. Am J Occup Ther. 2019; 73(4): 7304205050p1-7304205050p8. DOI:10.5014/ ajot.2019.031112.

26. Nardone R, Höller Y, Brigo F, et al. The contribution ofneurophysiology in the diagnosis and management ofcervical spondylotic myelopathy: a review. Spinal Cord. 2016; 54(10): 756-766. DOI: 10.1038/sc.2016.82.

27. Патент РФ No 2717365, 23.03.2020. Померанцев А.А., Старкин А.Н. Способ оценки мелкой моторики рук // Патент России No 2018147383.2018. Бюл. No 9. [Pomerancev AA, Starkin AN. Sposob ocenki melkoj motoriki ruk [Method for assessing hand fine motor skills]. RF Patent [Patent RU]. No 2018147383.2018; 9. (In Russ.)].

 

UDC 616-036.22:578.834.1-06:616.24

DOI:10.20969/VSKM.2022.15 (6).78-84

PDF download THE CLINICAL FEATURES OF RECOVERY IN PATIENTS WHO HAD CORONAVIRUS INFECTION COVID-19 BASED ON THE DURATION OF POST-COVID PERIOD AND SEVERITY OF LUNG PARENCHYMAL ABNORMALITIES

PRASKURNICHY EVGENY A., ORCID ID: 0000-0002-9523-5966; D. Med. Sci., professor, the Head of the Department of Internal Medicine of State Scientific Center of the Russian Federation – Federal Medical Biophysical Center named after A.I. Burnazyan, Russia, Moscow, 123098, Zhivopisnaya str., 46, e-mail: praskurnichey@mail.ru

ZENKOVA SVETLANA I., ORCID ID: 0000-0003-1161-713X; endocrinologist of Central Clinical Health Resort for Children with Parents «Malakhovka», Russia, 140033, Moscow region, Malakhovka village, Kalinin str., 29, e-mail: sveta.zenkova.94@mail.ru

TRIGOLOSOVA IRINA V., ORCID ID: 0000-0002-8397-3304; C. Med. Sci., associate professor of the Department of Internal Medicine of State Scientific Center of the Russian Federation – Federal Medical Biophysical Center named after A.I. Burnazyan, Russia, 123098, Moscow, Zhivopisnaya str., 46; endocrinologist of Central Clinical Health Resort for Children with Parents «Malakhovka», Russia, 140033, Moscow region, Malakhovka village, Kalinin str., 29, e-mail: trigolosova_ira@mail.ru

ORLOVA OLGA S., ORCID ID: 0000-0002-7222-9731; postgraduate student of the Department of Internal Medicine of State Scientific Center of the Russian Federation – Federal Medical Biophysical Center named after A.I. Burnazyan, Russia, 123098, Moscow, Zhivopisnaya str., 46, e-mail: orlova.os@mail.ru

ELEZOVA LYUBOV I., ORCID ID: 0000-0002-5592-1232; C. Med. Sci., deputy chief of Medical Officer of the Central Clinical Health Resort for Children with Parents «Malakhovka», Russia, 140033, Moscow region, Malakhovka village, Kalinin str., 29, e-maill: elelu@mail.ru

SHMAKOV NIKOLAI A., ORCID ID 0000-0002-6721-8464; C. Med. Sci., Chief physician of the Central Clinical Health Resort for Children with Parents «Malakhovka», Russia, 140033, Moscow region, Malakhovka village, Kalinin str., 29, e-mai: cdksmal@mail.ru

Abstract. Introduction. Post-COVID syndrome is a complex of symptoms that develops in almost half of the patients who have had a new coronavirus infection (COVID-19). The frequency of symptom development based on the duration of the post-COVID period, age, gender, and severity of the course of the disease are highly relevant subjects, as they will allow to form approaches to the diagnosis, treatment, and prevention of post-COVID syndrome. Material and methods. 43 patients were included (men – 10, women – 33), age 65 [60–71]. The questionnaire was designed after a comprehensive review of literature from the past studies based on similar objectives. We divided patients in two groups in depending on recovery: up to 3 months (n=23), after to 3 months (n=20). In depend on degree of lung parenchymal abnormalities two groups were formed: less than 25%, more than 25%. Vital signs (respiratory rate, SpO2, hearth rate) were collected. The tolerance in physical activity we investigate by modi ed Medical Research Council breathlessness scale – mMRC, six-minute test. Borgscale, hurt rate and oxygen saturation were measured immediately before and after test. Data were analyzed using Statistical Package for Social Sciences version 22.0. Results and discussion.The majority of the patients complained on persistent fatigue (75%), dyspnea (59%), joint pain (45%), anxiety (38%) and chest pain (37%). We didn’t nd difference in frequencies of majority of complaints in depend on duration of post-COVID period. In patients with LA>25% mMRC, respiratory rate, Borg scale in six-minute test higher than in patientswith LA<25%. Conclusion. In elderly patients, symptoms persisted for more than 3 months after a new coronavirus infection, which is associated with a higher risk of chronic pathological processes in elderly patients. With lung lesion volume of more than 25%, respiratory functional test values are higher than in the group of patients with smaller lesion volume, which is most likely caused by preserved structural damage of lung tissue.

Key words: coronavirus infection, post-COVID-19 period, post-COVID-19 syndrome, rehabilitation, pandemic.

For reference: Praskurnichiy EA, Zenkova SI, Trigolosova IV, et al. The clinical features of recovery in patients who had coronavirus infection COVID-19 based on the duration of post-covid period and severity of lung parenchymal abnor-malities. The Bulletin of Contemporary Clinical Medicine. 2022; 15 (6): 78-84.DOI: 10.20969/VSKM.2022.15(6).78-84.

References

1. Воробьев П.А. (ред.). Рекомендации по ведению больных с коронавирусной инфекцией COVID-19 в острой фазе и при постковидном синдроме в амбулаторных условиях // Проблемы стандартизации в здравоохранении. – 2021. – T.7, вып.8. – C. 3–96. [Vorobyov PA (editor). Rekomendacii po vedeniyu bol’nyh s koronavirusnoj infekciej COVID-19 v ostroj faze i pri postkovidnom sindrome v ambulatornyh usloviyah [Recommendations for following up with ambulant coronavirus disease COVID-19 in the acute phase Post-COVID-19 period patients]. Problemy standartizacii v zdravoohranenii [Health Care Standardization Problem]. 2021; 7(8): 3-96. (In Russ.)].

2. Moriguchi T, Harii N, Goto J, Harada D, Sugawara H, et al. A rst case of meningitis/encephalitis associated with SARS-Coronavirus-2. Int J Infect Dis. 2020; 94: 55-58. DOI: 10.1016/ j.ijid.2020.03.062.

3. Бескаравайная Т.В. В МКБ-10 добавлен постковидный синдром // Медвестник. – 2020. [Beskaravaynaya Т.V. V MKB-10 dobavlen postkovidnyj sindrom [Added Post-COVID-19 syndrome to ICD-10]. Medvestnik [Medveslnik]. 2020. (In Russ.)].

4. Международная статистическая классификация болезней и проблем, связанных со здоровьем, 10-го пересмотра, официальная обновляемая онлайн версия. [Mezhdunarodnaya statisticheskaya klassi kaciya boleznej i problem, svyazannyh so zdorov’em, 10-go peresmotra, o cial’naya obnovlyaemaya onlajn versiya [Of cial updated Russian-language online version of ICD-10]. (In Russ.)]. URL: https://mkb-10.com

5. Iqbal A, Iqbal K, Arshad Ali S, et al. The COVID-19 Sequelae: A Cross-Sectional Evaluation of Post-recovery Symptoms and the Need for Rehabilitation of COVID-19 Survivors. Cureus. 2021; 13 (2): e13080. DOI: 10.7759/cureus.13080.

6. Anastasio F, Barbuto S, Scarnecchia E, et al. Medium-term impact of COVID-19 on pulmonary function, functional capacity and quality of life. Eur Respir J. 2021; 58 (3): 2004015. DOI: 10.1183/13993003.04015-2020.

7. Raman B, Cassar MP, Tunnicliffe EM, et al. Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge. E Clinical Medicine. 2021; 31: 100683. DOI: 10.1016 / j.eclinm.2020.100683.

8. Dar SA, Khurshid SQ, Wani ZA, et al. Stigma in coronavirus disease-19 survivors in Kashmir, India: a crosssectional exploratory study. PLoSOne. 2020; 15(11): e0240152.
DOI: 10.1371/journal.pone.0240152.

9. Kamal M, Abo Omirah M, Hussein A, Saeed H. Assessment and characterisation of post-COVID-19 manifestations. Int J Clin Pract. 2021; 75 (3): e13746. DOI: 10.1111/ ijcp.13746.

10. Авдеев А.В., Адамян Л.В., Алексеева Е.И. [и др.]. Временные методические рекомендации Министерства здравоохранения Российской Федерации «Профилактика, диагностика и лечение новой коронавирусной инфекции COVID-19», 12-я версия от 21.09.21 / Министерство здравоохранения Российской Федерации. – Москва, 2021. – 231 с. [Avdeev AV, Adamyan LV, Alekseeva EI, et al. Vremennye metodicheskie rekomendacii Ministerstva Zdravoohraneniya Rossijskoj Federacii «Pro laktika, diagnostika i lechenie novoj koronavirusnoj infekcii COVID-19», 12 versiya of 21.09.21 [Interim guidelines of the Ministry of Health of the Russian Federation «Prevention, diagnosis and treatment of a new coronavirus infection COVID-19», version 12 of 21.09.21] Ministerstvo zdravoohraneniya Rossijskoj Federacii [Ministry of Health of the Russian Federation]. Moskva [Moscow]: 2021; 231. (In Russ.)]. URL: https:// static0.minzdrav.gov.ru/system/attachments/attaches/000/058/075/original/%D0%92%D0%9C%D0%A0_COVID–19_V12.pdf

11. Singh AK, Gupta R, Ghosh A, Misra A. Diabetes in COVID-19: Prevalence, pathophysiology, prognosis and practical considerations. Diabetes Metab Syndr. 2020;14(4): 303-310. DOI: 10.1016 / j.dsx.2020.04.004.

12. Iaccarino G, Grassi G, Borghi C, et al. Age and Multimorbidity Predict Death Among COVID-19 Patients: Results of the SARS-RAS Study of the Italian Society of Hypertension. Hypertension. 2020; 76 (2): 366-372. DOI: 10.1161 / HYPERTENSIONAHA.120.15324.

13. Gu J, Han B, Wang J. COVID-19: Gastrointestinal Manifestations and Potential Fecal-Oral Transmission. Gastroenterology. 2020; 158(6):1518-1519. DOI: 10.1053/ j.gastro.2020.02.054.

14. Zheng KI, Gao F, Wang XB, et al. Letter to the Editor: Obesity as a risk factor for greater severity of COVID-19 in patients with metabolic associated fatty liver disease. Metabolism. 2020; 108:154-244. DOI: 10.1016/j.metabol.2020.154244.

15. Jothimani D, Venugopal R, Abedin MF, et al. COVID-19 and the liver. J Hepatol. 2020; 73(5):1231-1240. DOI: 10.1016 / j.jhep.2020.06.006.

 

UDC 616.24-008.4-07:616.711-007.274:578.834.1

DOI: 10.20969/VSKM.2022.15(6).85-92

PDF download LUNG FUNCTION DISORDERS IN PATIENTS WITH ANKYLOSING SPONDYLITIS AND THEIR DYNAMICS AFTER A NEW CORONAVIRUS INFECTION COVID-19

SAVUSHKINA OLGA I., ORCID ID: 0000-0002-7486-4990; C. Bio. Sci., the Head of the Department of lung function testing of Center of Functional Diagnostic Investigations of Main Military Clinical Hospital named after N.N. Burdenko, Russia, 105094, Moscow, Gospital’naya sq., 3; senior researcher of Laboratory of functional and utrasound research Methods of Pulmonology Scientific Research Institute, Russia, 115682, Moscow, Orekhovyi av., 28, tel. +7-499-263-38-61, +7-926-231-84-12, e-mail: olga-savushkina@yandex.ru

ZAYTSEV ANDREY A., ORCID ID: 0000-0002-0934-7313; D. Med. Sci., professor, Honored Doctor Russian Federation, chief pulmonologist of Main Military Clinical Hospital named after N.N. Burdenko, Russia, 105094, Moscow, Gospital’naya sq., 3; the Head of the Department of pulmonology (with a course in allergology) of Moscow State University of Food Production, Russia, 125080, Moscow, Volokolamsk highway, 11, tel. +7-499-263-10-47, +7-916-588-32-12, e-mail: a-zaicev@yandex.ru

MALASHENKO MARIA M., ORCID ID: 0000-0002-1648-798Х; C. Med. Sci., the Head of the Department of physiotherapy of Main Military Clinical Hospital named after N.N. Burdenko, Russia, 105094, Moscow, Gospital’naya sq., 3, tel. +7-910-451-55-89, e-mail: mar-malashenko@yandex.ru

ASEEVA NATALIYA A., ORCID ID: 0000-0002-3882-8132; doctor of the Department of lung function testing of Center of Functional Diagnostic Investigations of Main Military Clinical Hospital named after N.N. Burdenko, Russia, 105094, Moscow, Gospital’naya sq., 3, tel. +7-499-263-38-61, e-mail: aweesa@yandex.ru

ASTANIN PAVEL A., ORCID ID: 0000-0002-1854-8686; postgraduate student, assistant professor of the Department of medical cybernetics and informatics of Russian National Research Medical University named after N.I. Pirogov, Russia, 117321, Moscow, Ostrovityanov str., 1, tel. +7-983-158-08-14, e-mail: med_cyber@mail.ru

KRYUKOV EVGENIY V., ORCID ID: 0000-0002-8396-1936; D. Med. Sci., professor, Corresponding Member of the Russian Academy of Sciences, Commander of Military Medical Academy named after S.M. Kirov, Russia, 194044, St. Petersburg, Akademic Lebedev str., 6, tel. +7-812-667-71-18, e-mail: evgeniy.md@mail.ru

Abstract. Introduction. Lung function disorders in patients with ankylosing spondylitis can be caused both by the disease itself and the side effect of the treatment. Aim. The aim was to investigate the lung function in patients with ankylosing spondylitis and analyze its dynamics after COVID-19 on the example of clinical case. Material and methods. 29 patients were enrolled in the study. Spirometry, body plethysmography, diffusion test was performed. In 1 patient the dynamics of parameters was analysed after COVID-19. Statistical analyses were performed using SPSS 23.0. Quantitative data with a normal distribution were presented as the mean and standard deviation (m±σ). The data with different type of distribution were presented as the median and interquartile range (Me [Q1; Q3]). The differences between quantitative parameters were assessed by student’s t-test for data with normal distribution and by the Wilcoxon test for data with different distribution. To assess the differences between qualitative parameters the Fisher’s exact test was used. A value of p<0,05 was considered to be statistically signi cant. Results and discussion. A retrospective cross-sectional study was performed. The predicted values of the European Community for Steel and Coal 1993 and the Global Lung function Initiative were used in the analysis. On average, no ventilation disorders were detected in the group. However, 7 (24%) patients had airway obstruction. Restriction and impaired lung diffusion capacity were detected in 3 (10%) and 12 (41%) patients using European Community for Steel and Coal 1993 predicted values system and in 2 (7%) and 6 (21%) patients using the Global Lung function Initiative predicted values system respectively. The differences were statistically signi cant. In clinical case, the previously established lung function disorders became more pronounced after COVID-19: ventilation capacity, total lung capacity, diffusion lung capacity decreased by 50%, 35%, 38% respectively.Conclusion. Lung function tests should be included in the examination plan of patients with ankylosing spondylitis. Patients with ankylosing spondylitis may have a more severe course of COVID-19. The system of the predicted values used should be presented in the medical report.

Key words: ankylosing spondylitis, pulmonary function tests, new coronavirus disease.

For reference: Savushkina OI, Zaytsev АА, Malashenko ММ, et al. Lung function disorders in patients with ankylosing spondylitis and their dynamics after a new coronavirus infection COVID-19. The Bulletin of Contemporary Clinical Medicine. 2022; 15 (6): 85-92. DOI: 10.20969/VSKM.2022.15(6).85-92.

References

1. Мазуров В.И. Клиническая ревматология. Руководство для врачей. – Москва: Е-ното, 2021. – 696 с. [Mazurov VI. Klinicheskaya revmatologiya. Rukovodstvo dlya vrachej [Clinical rheumatology. Guide for doctors]. Moskva: E-noto, 2021; 696 (In Russ.)].

2. Осипок Н.В., Щукина С.В., Дмитриченко Т.М. Факторы риска развития и прогрессирования поражения легких у больных анкилозирующим спондилитом // Сибирский медицинский журнал. – 2010. – No 5. – С. 44–47. [Osipok NV, Shchukina SV, Dmitrichenko TM. Faktory riska razvitiya i progressirovaniya porazheniya legkih u bol’nyh ankiloziruyushchim spondilitom [Risk factors of development and progressing of pulmonary lesion in patients with ankylosing spondiloarthritis]. Sibirskij medicinskij zhurnal [Siberian Medical Journal]. 2010; 5: 44-47. (In Russ.)].

3. Wang R, Ward MM. Epidemiology of axial spondyloarthritis: an update. Current Opinion in Rheumatology. 2018; 30 (2). 137-143. DOI: 10.1097/BOR.0000000000000475.

4. Астанин П.А., Наркевич А.Н. Цифровые технологии в оценке течения заболеваний с выраженным болевым синдромом на примере анкилозирующего спондилита // Российский журнал боли. – 2021. – Т. 19, No 2. – С. 38–41. [Astanin PA, Narkevich AN. Cifrovye tekhnologii v ocenke techeniya zabolevanij s vyrazhennym bolevym sindromom na primere ankiloziruyushchego spondilita [Digital technology for estimation of course of diseases with acute pain syndrome on the example of ankylosing spondylitis]. Rossijskij zhurnal boli [Russian Journal of Pain]. 2021; 2: 38-41. (In Russ.)]. DOI: 10.17116/ pain20211902138.

5. Hegedűs B, Varga J, Somfay A. Interdisciplinary rehabilitation in patients with ankylosing spondylitis. Orv. Hetil. 2016; 157 (28): 1126-1132. DOI: 10.1556/650.2016.30472.

6. Berdal G, Halvorsen S, van der Heijde D, et al. Restrictive pulmonary function is more prevalent in patients with ankylosing spondylitis than in matched population controls and is associated with impaired spinal mobility: A comparative study. Arthritis Research & Therapy. 2012; 14 (1): 19. DOI: 10.1186/ar3699.

7. Liu Ch, Wu B, Guo Y, et al. Correlation between diaphragmatic sagittal rotation and pulmonary dysfunction in patients with ankylosing spondylitis accompanied by kyphosis. J. Int. Med. Res. 2019; 47 (5): 1877-1883. DOI: 10.1177/0300060518811486.

8. Чучалин А.Г. Пульмонология. Национальное руководство. Краткое издание. – Москва: ГЭОТАР-Медиа, 2013. – 768 с. [Chuchalin AG. Pul’monologiya. Nacional’noe rukovodstvo. Kratkoe izdanie [Pulmonology. National leadership. Short edition]. Moskva: GEOTAR-Media, 2013; 768. (In Russ.)].

9. Wanger J, Clausen JL, Coates A, et al. Standardisation of the measurement of lung volumes. Eur. Respir. J. 2005; 26 (3): 511-522. DOI: 10.1183/09031936.05.00035005.

10. Graham BL, Brusasco V, Burgos F, et al. ERS/ATS Standards for single-breath carbon monoxide uptake in the lung. Eur. Respir. J. 2017; 49: 1600016. DOI: 10.1183/13993003.00016-2016.

11. Graham BL, Steenbruggen I, Miller MR, et al. Standardization of Spirometry 2019 Update. An Of cial American Thoracic Society and European Respiratory Society Technical Statement. Am J Respir Crit Care Med. 2019; 200 (8): 70-88. DOI: 10.1164/rccm.201908-1590ST.

12. Спирометрия. Методическое руководство // Российское респираторное общество. – 2021. – 62 с. [Spirometriya. Metodicheskoe rukovodstvo [Spirometry. Methodological guide]. Rossijskoe respiratornoe obshchestvo [Russian respiratory society]. 2021; 62. (In Russ.)].

13. Pellegrino R, Viegi G, Brusasco V, et al. Interpretative strategies for lung function tests. Eur. Respir. J. 2005; 26 (5): 948-968. DOI: 10.1183/09031936.05.00035205.

14. Ахатова С.Р., Мингазетдинова Л.Н. Оценка состояния функции внешнего дыхания и внутрилегочной гемодинамики в патогенезе анкилозирующего спондилоартрита // Вестник Башкирского университета. – 2006. – No 3. – С 1–3. [Ahatova SR, Mingazetdinova LN. Ocenka sostoyaniya funkcii vneshnego dyhaniya i vnutrilegochnoj gemodinamiki v patogeneze ankiloziruyushchego spondiloartrita [External respiration function and intrapulmonary hemodynamics assessment in the ankylosing spondylitis pathogenesis]. Vestnik Bashkirskogo universiteta [Bulletin of Bashkir University]. 2006; 3: 1-3. (In Russ.)].

15. Ozdemir O, Akpınar MG, Inanici F, et al. Pulmonary abnormalities on high-resolution computed tomography in ankylosing spondylitis: relationship to disease duration and pulmonary function testing. Rheumatol Int. 2012; 32 (7): 2031-2036. DOI: 10.1007/s00296-011-1923-x.

16. Er G, Angin E. Determining the relationship of kinesiophobia with respiratory functions and functional capacity in ankylosing spondylitis. Medicine. 2017; 96 (29): 74-86. DOI: 10.1097/MD.0000000000007486.

17. Hasiloglu ZI, Havan N, Rezvani A., et al. Lung parenchymal changes in patients with ankylosing spondylitis. World J. Radiol. 2012; 4 (5): 215-219. DOI: 10.4329/wjr.v4.i5.215.

18. Maghraoui Al, Dehhaoui M. Prevalence and characteristics of lung involvement on high resolution computed tomography in patients with ankylosing spondylitis: a systematic review. Pulmonary Medicine. 2012; 2: 965-956. DOI: 10.1155/2012/965956.

19. Wardyn PM, de Broucker V, Chenivesse C, et al. Assessing the applicability of the new Global Lung Function Initiative reference values for the diffusing capacity of the lung for carbon monoxide in a large population set. PLoS One. 2021; 16 (1): e0245434. DOI: 10.1371/journal.pone.0245434.

20. Quanjer PH, Stanojevic S, Cole TJ, et al. ERS Global
Lung Function Initiative. Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations. Eur Respir J. 2012; 40 (6): 1324-1343. DOI: 10.1183/09031936.00080312.

21. Stanojevic S, Graham BL, Cooper BG, et al. Of cial ERS technical standards: Global Lung Function Initiative reference values for the carbon monoxide transfer factor for Caucasians. Eur Respir J. 2017; 50: 1700010. DOI: 10.1183/13993003.00010-2017.

22. Hall GL, Filipow N, Ruppel G, et al. Of cial ERS technical standard: Global Lung Function Initiative reference values for static lung volumes in individuals of European ancestry. Eur Respir J. 2021; 57 (3): 2000289. DOI: 10.1183/13993003.00289-2020.

23. Gica Ş, Akkubak Y, Aksoy ZK, et al. Effects of the COVID-19 pandemic on psychology and disease activity in patients with ankylosing spondylitis and rheumatoid arthritis. Turk J Med Sci. 2021; 51: 1631-1639. DOI: 10.3906/sag-2011-188.

24. Fredi M, Cavazzana L, Moschetti L, et al. COVID-19 in patients with rheumatic diseases in northern Italy: a single-centre observational and case-control study. Lancet Rheumatol. 2020; 2 (9): 549-556. DOI: 10.1016/S2665-9913(20)30169-7.

25. Ciurea A, Papagiannoulis E, Bürki K, et al. Impact of the COVID-19 pandemic on the disease course of patients with in ammatory rheumatic diseases: results from the Swiss Clinical Quality Management cohort. Ann Rheum Dis. 2020; 80 (2): 1-4. DOI: 10.1136/annrheumdis-2020-218705.

26. Зайцев А.А., Голухова Е.З., Мамалыга М.Л. Эффективность пульс-терапии метилпреднизолоном у пациентов с COVID-19 // Клиническая микробиология и антимикробная химиотерапия. – 2020. – No 22 (2). – С. 88–91. [Zaitsev AA, Golukhova EZ, Mamalyga ML. Effektivnost’ pul’s-terapii metilprednizolonom u pacientov s COVID-19 [Ef cacy of methylprednisolone pulse therapy in patients with COVID-19]. Klinicheskaya mikrobiologiya i antimikrobnaya himioterapiya [Clinical Microbiology and Antimicrobial Chemotherapy]. 2020; 22(2): 88-91. (In Russ.)]. DOI: 10.36488/cmac.2020.2.88-91.

 

UDC 616.379-008.64-036.88:616.127-005.8-06

DOI: 10.20969/VSKM.2022.15(6).93-99

PDF download ONE-YEAR MORTALITY IN PATIENTS WITH DIABETES MELLITUS TYPE II AFTER ACUTE ANTERIOR MYOCARDIAL INFARCTION WITH Q-WAVE

SOKUEVA KHEDI YU., ORCID ID: 0000-0002-6706-1153; postgraduate student of the Department of endocrinology of faculty of advanced training and professional specialist retraining of Kuban State Medical University, Russia, 350063, Krasnodar, Sedin str., 4, tel. +7-928-738-38-82, e-mail: s.khaidi@yandex.ru

Abstract. Introduction. Type II diabetes is now a global epidemic, its prevalence has signi cantly increased globally. Myocardial infarction is the primary cause of death in type II diabetes patients. Aim. The aim is to study one-year mortality in patients with diabetes mellitus type II after acute anterior myocardial infarction with Q-wave, receiving one of the sulfonylureas. Material and methods. Participated in the study 246 patients with type II diabetes and acute anterior Q-wave myocardial infarction receiving sulfonylureas. The patients were divided into 2 groups: control group (n=156) and the main group (n=90). All patients received standard examination and treatment of acute myocardial infarction. Patients from the main group were given a second breakfast 2 hours after taking sulfonylurea to prevent hypoglycemic reactions. Results and discussion. One year after acute anterior Q-wave myocardial infarction in patients with type II diabetes mellitus mortality in the control group was 26,2% (n=41), and in the main group – 1,1% (n=1). The mortality rate in the control group was signi cantly higher, which was statistically signi cant (p<0,05). The main cause of mortality in patients in control was a severe degree of chronic heart failure (31,7%, n=13), in second place are episodes of heart arrhythmia (24,3%, n=10), and repeated myocardial infarction (24,3%, n=10), and the rarest cause was pulmonary embolism (3,7%, n=3). The greatest mortality in the control group was observed in the glibenclamide subgroup (39%, n=16), then in the glimepiride subgroup (34,1%, n=14) and gliclazide (26,9%, n=11). In the control group, hypoglycemia was higher (49,3%, n=78) than in the main group (15,5%, n=14), which was statistically signi cant (p<0,05). The incidence of hypoglycemia in the glibenclamide subgroup was statistically higher (p<0,05) than in the gliclazide and glimepiride subgroups. Conclusion. Mortality in patients with type II diabetes within a year after an acute anterior myocardial infarction with a Q-wave in a group of patients where the risk of receiving repeated hypoglycemic reactions is minimized is signi cantly less.

Key words: sulfonylureas, diabetes mellitus, myocardial infarction, mortality, cardiovascular disease.

For reference: Sokueva KhYu. One-year mortality in patients with diabetes mellitus type II after acute anterior myocardial infarction with Q-wave. The Bulletin of Contemporary Clinical Medicine. 2022; 15(6): 93-99.

References

1. DF Diabetes Atlas, 8th edition. Brussels: International Diabetes Federation; 2017. Available from: https://www. idf.org/e-library/epidemiologyresearch/diabetes-atlas/134-idf-diabetes-atlas-8th-edition. html.

2. Остроумова О.Д., Голобородова И.В., Фомина В.М. Сердечно-сосудистые риски у больных сахарным диабетом II типа // Кардиоваскулярная терапия и профилактика. – 2018. – Т. 17, No 3. – С.81–94. [Ostroumova O.D., Goloborodova I.V., Fomina V.M. Serdechno-sosudistyye riski u bol’nykh sakharnym diabetom 2 tipa [Cardiovascular risk in type II diabetes patients.] Kardiovaskulyarnaya terapiya i profilaktika [Cardiovascular Therapy and Prevention]. 2018; 17(3): 81-94. (In Russ.)]. DOI:10.15829/1728-8800-2018-4-81-94.

3. Bertoluci MC, Rocha VZ. Cardiovascular risk assessment in patients with diabetes. Diabetol Metab Syndr. 2017; 19(9): 70. DOI:10.1186/s13098-017-0270-9.

4. Avogaro A, Bonora E, Consoli A, et al. Glucose-lowering therapy and cardiovascular outcomes in patients with type 2 diabetes mellitus and acute coronary syndrome. Diab Vasc Dis Res. 2019; 16: 399-414. DOI: 10.1177/1479164119845612.

5. Hajar R. Diabetes as «Coronary Artery Disease Risk Equivalent»: A Historical Perspective. Heart Views. 2017; 18 (1): 34-37. DOI: 10.4103/HEARTVIEWS. HEARTVIEWS_37_17.

6. Macisaac RJ, Jerums G. Intensive glucose control and cardiovascular outcomes in type 2 diabetes. Heart Lung Circ. 2010; 20(10): 647-654. DOI: 10.1016/j. hlc.2010.07.013.

7. Yamada M, Kurachi Y. The nucleotide-binding domains of sulfonylurea receptor 2A and 2B play different functional roles in nicorandil-induced activation of ATP-sensitive K+ channels. Journal Mol Pharmacol. 2004; 65(5): 1198-1207. DOI: 10.1124/mol.65.5.1198.

8. Lee TF, Burt MG, Heilbronn LK, et al. Relative hyperglycemia is associated with complications following an acute myocardial infarction: a post-hoc analysis of HI-5 data. Cardiovasc Diabetol. 2017; 16: 157. DOI: 10.1186/ s12933-017-0642-3.

9. Bolk J, van der Ploeg T, Cornel JH, et al. Impaired glucose metabolism predicts mortality after a myocardial infarction. Int J Cardiol. 2001; 79: 207-214.

10. Hanefeld M, Frier BM, Pistrosch F. Hypoglycemia and cardiovascular risk: is there a major link? Diabetes Care. 2016; 39: 205-209.

11. Иванова Л.А., Сокуева Х.Ю., Король И.В. Влияние второго завтрака на частоту гипогликемических состояний у больных сахарным диабетом II типа и острым инфарктом миокарда с зубцом Q, получающих препараты сульфонилмочевины // Вестник современной клинической медицины. – 2019. – Т. 12, No 3. – С.33–39. [Ivanova LA, Sokueva HYu, Korol IV. Vliyaniye vtorogo zavtraka na chastotu gipoglikemicheskikh sostoyaniy u bol’nykh sakharnym diabetom II tipa i ostrym infarktom miokarda s zubtsom Q, poluchayushchikh preparaty sul’fonilmocheviny [The impact of the second breakfast on the frequency of hypoglycemic states in patients with type II diabetes mellitus and acute myocardial infarction with Q-vawe, receiving sulphonylurea medications]. Vestnik sovremennoy klinicheskoy meditsiny [The Bulletin of Contemporary Clinical Medicine]. 2019; 12(3): 33-39. (In Russ.)]. DOI: 10.20969/VSKM.2019.12(3).33-39.

12. Dluhi RG, McMahonn GT. Intensive Glycemic Control in the ACCORD and ADVANCE Trials. N Eng J Med. 2008; 358: 2630-2633. DOI: 10.1056/NEJMe0804182.

13. Witte DR, Tesfaye S, Chaturvedi N, et al. Risk factors for cardiac autonomic neuropathy in type 1 diabetes mellitus. Diabetologia. 2005; 48(1): 164-171. DOI:10.1007/s00125-004-1617-y.

14. Yang Sh, Park K, Zhou Yu. The Impact of Hypoglycemia on the Cardiovascular System: Physiology and Pathophysiology. Angiology. 2016; 67(9): 802-809. DOI: 10.1177/0003319715623400.

 

UDC 577.125.8:616.89-008.441.3+612.397.23

DOI: 10.20969/VSKM.2022.15(6).100-108

PDF download THE ROLE OF FATTY ACIDS IN THE LIPID METABOLISM DISORDERS MECHANISMS IN INDIVIDUALS WITH ALCOHOL DEPENDENT SYNDROME

SOLOVYEVA VERONICA A., ORCID ID: 0000-0002-2954-8040; postgraduate student of the Department of human biology and biotechnical systems of Northern (Arctic) Federal University named after M.V. Lomonosov, Russia, 163000, Arkhangelsk, Embankment Severnaya Dvina, 17, e-mail: taurus221@ yandex.ru

LEIKHTER SVETLANA N., ORCID ID: 0000-0002-0538-6753; C. Biol. Sci., associate professor of the Department of clinical biochemistry microbiology and laboratory diagnostics of Northern State Medical University, Russia, 163000, Arkhangelsk, Troitsky av. 51, e-mail: sleihter@rambler.ru

SOLOVIEVA NATALIA V., ORCID ID: 0000-0002-0664-4224; D. Med. Sci., associate professor, the Head of the Department of pathological physiology of Northern State Medical University, Russia, 163000, Arkhangelsk, Troitskiy av., 51, e-mail: patophiz@yandex.ru

BICHKAEVA FATIMA A., ORCID ID: 0000-0001-8507-1489; D. Biol. Sci.,the Head of the Laboratory of biological and inorganic chemistry of Federal Research Center for Integrated Arctic Research named after N.P. Laverov–Ural branch of Russian Academy of Sciences, Russia, 163000, Arkhangelsk, Lomonosov av., 249, e-mail: fatima@fciarctic.ru

ISHEKOV NICOLAY S., ORCID ID: 0000-0002-1537-035X; D. Med. Sci., professor of the Department of psychiatry and clinical psychology of Northern State Medical University, Russia, 163000, Arkhangelsk, Troitsky av., 51, e-mail: ishekovani@mail.ru

KARYAKINA OLGA E., ORCID ID: 0000-0003-0781-0164; C. Biol. Sci., associate professor of the Department of human biology and biotechnical systems of Northern (Arctic) Federal University named after M.V. Lomonosov, Russia, 163000, Arkhangelsk, Embankment Severnaya Dvina, 17, e-mail: novogil@mail.ru

SOLOVIEV ANDREY G., ORCID ID: 0000-0002-0350-1359; D. Med. Sci., professor, the Head of the Department of psychiatry and clinical psychology of Northern State Medical University, Russia, 163000, Arkhangelsk, Troitsky av., 51, e-mail: asoloviev1@yandex.ru

UDOVENKOVA LARISA P., ORCID ID: 0000-0001-9835-025X; deputy chief of First City Clinical Hospital named after E.E. Volosevich, Russia, 163001, Arkhangelsk, Suvorov str., 1, e-mail: udovenkovalp@gmail.com

VILOVA TATYANA V., ORCID ID 0000-0002-8481-6511; D. Med. Sci., professor of the Department of therapeutic dentistry of Northern State Medical University, Russia, 163000, Arkhangelsk, Troitsky av., 51, e-mail: vitavladi@list.ru

Abstract. Introduction. The determination of blood serum fatty acid composition is promising in lipid metabolismdisorders study in narcological patients. Aim. The study aim was to establish the fatty acids role in lipid metabolism disorders mechanisms in patients with alcohol dependence syndrome. Material and methods. 208 people were examined, including 96 patients with the second stage alcohol dependence syndrome; 112 people were practically healthy persons during professional examinations. Saturated, monounsaturated, polyunsaturated fatty acids were determined by gas-liquid chromatography. The total polyunsaturated content, omega-3 and omega-6 acids was calculated. Statistical processing was carried out using the SPSS 15.0 application software package. Results and discussion. In narcological patients, a low saturated fatty acids content was revealed, which, against the liver dysfunction background, leads to their insuf cient inclusion in the triglycerides and low-density lipoproteins structure. The low content of ω-3 α-linolenic, docosahexaenoic and ω-6-linoleic, arachidonic acids helps to reduce the biologically active substances synthesis with pro- and anti-in ammatory activity. The necessity of blood serum fatty acid composition purposeful study to clarify the comorbid alcohol-attributive morbidity development is substantiated. Conclusion. To identify the lipid metabolismdisorders mechanisms in narcological patients, it is more important to determine not the lipid metabolism «traditional» parameters, but the blood serum fatty acid composition. The low ω-3 and ω-6 fatty acids content affects the biologically active substances synthesis with pro- and anti-in ammatory activity, which may explain the decrease in reactivity in patients with somatic pathology. The identi ed alcohol-associated violation the fatty acid composition signs can be considered as chronic alcohol intoxication screening markers when conducting lipid metabolism study in drug-related risk groups, for example, when they are in somatic hospitals.

Key words: alcohol dependence syndrome, lipid metabolism, disruption mechanisms, fatty acids.

For reference: Solovieva VA, Leihter SN, Solovyeva NV, et al. The role of fatty acids in the lipid metabolism disorders mechanisms in individuals with alcohol dependence syndrome. The Bulletin of Contemporary Clinical Medicine. 2022; 15(6):100-108. DOI: 10.20969/VSKM.2022.15(6).100-108.

References

1. Вязьмин А.М. Мордовский Э.А., Соловьев А.Г. Смерт-ность от состояний, связанных с употреблением алкоголя // Проблемы социальной гигиены, здравоохранения и истории медицины. – 2013. –No 2. – С.13–16. [Vyazmin AM, Mordovian EA, Soloviev AG. Smertnost’ ot sostoyanij, svyazannyh s upotrebleniem alkogolya [Mortality from alcohol-related conditions]. Problemy social’noj gigieny, zdravoohraneniya i istorii mediciny [Problems of Social Hygiene, Public Health and the History of Medicine]. 2013; 2:13-16. (In Russ.)].

2. Сумин А.Н. Субклинический мультифакторный атеросклероз: как его выявить и надо ли? // Артериальная гипертензия. – 2017. – Т. 23, No 1. – С.69–73. [Sumin AN. Subklinicheskij mul’tifaktornyj ateroskleroz: kak ego vyyavit’ i nado li? [Subclinical multifactorial atherosclerosis: how to detect it and whether it is necessary?]. Arterial’naya gipertenziya [Arterial hypertension]. 2017; 23(1): 69-73. (In Russ.)]. DOI: 10.18705/1607-419X-2017-23-1-69-73.

3. Cecere A, Riccioni G, Sforza N, Marano R, et al. Coronary artery calcium score and coronary computed tomography angiography for patients with asymptomatic polyvascular (non-coronary) atherosclerosis // Singapore Med. J. 2016. DOI: 10.11622/smedj.2016186. [Epub ahead of print].

4. Драпкина О.М., Буеверова Е. Л., Ивашкин В.Т. Атерогенная дислипидемия и печень // Атеросклероз и дислипидемии. – 2010. – No 1. – С.25–31. [Drapkina OM, Bueverova EL, Ivashkin VT. Aterogennaya dislipidemiya I pechen’ [Atherogenic dyslipidemia and liver] Ateroskleroz i dislipidemii [The Journal of Atherosclerosis and Dyslipidemia]. 2010; 1: 25-31. (In Russ.)]. DOI: 10.34687/2219-8202.JAD.2021.02.0001.

5. Корок Е.В., Сумин А.Н., Синьков А.Н. [и др.]. Частота выявления интактных коронарных артерий в зависимости от показаний для плановой коронарной ангиографии // Российский кардиологический журнал. – 2016. – No 2 (130). – С.52–59. [Korok EV, Sumin AN, Sinkov AN, et al. Chastota vyyavleniya intaktnyh koronarnyh arterij v zavisimosti ot pokazanij dlya planovoj koronarno jangiogra i [Frequency of detection of intact coronary arteries depending on indications for planned coronary angiography] Rossijskij kardiologicheskij zhurnal [Russian Journal of Cardiology]. 2016; 2 (130): 52-59. (In Russ.)]. DOI: http // dx. doi .org / 10.15829/ 1560-4071-20156-2-52-59.

6. Тенюкова К.Ю., Марков Д.С. Скрининговые исследования липидного обмена для своевременной диагностики и профилактики атеросклероза // Вестник Чувашского университета. – 2011. – No 3. – С.463–466. [Tenyukova KYu, Markov DS. Skriningovye issledovaniya lipidnogo obmena dlya svoevremennoj diagnostiki i profilaktiki ateroskleroza [Screening studies of lipid metabolism for the timely diagnosis and prevention of atherosclerosis] Vestnik Chuvashskogo universiteta [Bulletin of the Chuvash University]. 2011; 3: 463-466. (In Russ.)].

7. Васильев В., Гордиенко А., Корнейчук Н. Алкогольная кардиомиопатия: эпидемиология, патогенез и принципы диагностики // Врач. – 2017. – No. 9. – С.6–8. [Vasiliev V, Gordienko A, Korneychuk N. Alkogol’naya kardiomiopatiya : epidemiologiya, patogenez I principy diagnostiki [Alcoholic cardiomyopathy: epidemiology, pathogenesis and principles of diagnosis]. Vrach [Doctor]. 2017; 9: 6-8. (In Russ.)].

8. Соколик В.В., Чурсина В.С., Артемчук А.А.Подавление активности сывороточной эстеразы и липопротеиновой липазы при остром и продолжительном действии этанола // Биомедицинская химия. – 2006. – No 1. – С.95– 100. [Sokolik VV, Chursina VS, Artemchuk AA. Podavlenie aktivnosti syvorotochnoj esterazy i lipoproteinovoj lipazy pri ostrom i prodolzhitel’nom dejstvii etanola [Suppression of the activity of serum esterase and lipoprotein lipase in acute and prolonged action of ethanol] Biomedicinskaya himiya [Biomedical chemistry]. 2006; 1: 95-100. (In Russ.)].

9. Тарасова О.И., Огурцов П.П., Мазурчик Н.В., Моисеев В.С. Современные лабораторные маркеры употребления алкоголя // Клиническая фармакология и терапия. – 2007. – Т. 16, No 1. – С.10–15. [Tarasova OI, Ogurcov PP, Mazurchik NV, Moiseev V.S. Sovremennye laboratornye marker upotrebleniya alkogolya [Modern laboratory markers of alcohol consumption] Klinicheskaya farmakologiya i terapiya [Clinical pharmacology and therapy]. 2007; 1 (16): 10-15. (In Russ.)].

10. Корякин А.М., Епифанцева Н.Н., Ещева Л.А. [и др.]. Повреждение, воспаление сосудистого эндотелия, гиперкоагуляция как факторы риска сердечно-сосудистых заболеваний у больных хроническим алкоголизмом // Сибирский медицинский журнал. – 2014. – No 4. – С.52–55. [Koryakin AM, Epifantseva NN, Eshcheva LA, et al. Povrezhdenie, vospalenie sosudistogo endoteliya, giperkoagulyaciya kak factory riska serdechno-sosudistyh zabolevanij u bol’nyh hronicheskim alkogolizmom [Damage, in ammation of the vascular endothelium, hypercoagulability as risk factors of cardiovascular disease in patients with chronic alcoholism] Sibirskij medicinskij zhurnal [Siberian medical journal]. 2014; 4: 52-55. (In Russ.)].

11. Жармаханова Г.М., Исакова С.С., Кайбагарова И.Б. [и др.]. Патофизиологические механизмы развития атеросклероза на фоне суточных колебаний гликемии // Медицинский журнал Западного Казахстана. – 2017. – No 2. – С.11–17. [Zharmahanova GM, Isakova SS, Kajbagarova IB, et al. Pato ziologicheskie mekhanizmy razvitiya ateroskleroza na fone sutochnyh kolebanij glikemii [Pathophysiological mechanisms of atherosclerosis development against the background of daily fluctuations of glycemia] Medicinskij zhurnal Zapadnogo Kazahstana [Medical Journal of Western Kazakhstan]. 2017; 2: 11-17. (In Russ.)].

12. Мартинчик А.Н., Кудрявцева К.В., Батурин А.К., Лобанов А.А. Потребление алкоголя взрослым населением Арктической зоны и населением других природно-климатических зон // Научный вестник Ямало-Ненецкого автономного округа. – 2017. – T. 2, No 95. – C.39–43. [Martinchik AN, Kudryavceva KV, Baturin AK, Lobanov AA. Potreblenie alkogolya vzroslym naseleniem Arkticheskoj zony I naseleniem drugih prirodno-klimaticheskih zon [Alcohol consumption in the adult population of the Arctic zone and the population of other climatic zones] Nauch. vestn. Yamalo-Nenec. avt. Okruga [Nauch. Vestn. Yamalo-Nenets. auth. Districts]. 2017; 2 (95): 39-43. (In Russ.)].

13. Рожкова Т.А., Ариповский А.В., Яровая Е.Б. [и др.]. Индивидуальные жирные кислоты плазмы крови: биологическая роль субстратов, параметры количества и качества, диагностика атеросклероза и атероматоза // Клиническая лабораторная диагностика. – 2017. – No 11. – С.655–665. [Rozhkova TA, Aripovsky AV, Yarovaya EB, et al. Individual’nye zhirnye kisloty plazmy krovi: biologicheskaya rol’ substratov, parameter y kolichestva I kachestva, diagnostika ateroskleroza I ateromatoza [Individual plasma fatty acids: biological role of substrates, parameters of quantity and quality, diagnosis of atherosclerosis and atheromatosis]. Klinicheskaya laboratornaya diagnostika [Clinical Laboratory Diagnostics]. 2017; 11: 655-665. (In Russ.)]. DOI: 10.18821/0869-2084-2017-62-11-655-665.

14. Таратухин Е.О. Атеросклероз и жирные кислоты: важная взаимосвязь и новое направление терапии // Российский кардиологический журнал. – 2011 – No 5. – С.77–80. [Taratuhin EO. Ateroskleroz i zhirnye kisloty: vazhnaya vzaimosvyaz’ i novoe napravlenie terapii [Atherosclerosis and fatty acids: an important relationship and a new direction of therapy] Rossijskij kardiologicheski jzhurnal [Russian Journal of Cardiology]. 2011; 5: 77-80. (In Russ.)].

15. Sakamoto A, Saotome M, Iguchi K, Maekawa Marine-Derived Y. Omega-3 Polyunsaturated Fatty Acids and Heart Failure: Current Understanding for Basic to Clinical Relevance. Int. J. Mol. Sci. 2019; 16(20): 123-130.

16. Ishihara T, Yoshida M, Arita M. Omega-3 fatty acid-derived mediators that control in ammation and tissue homeostasis. Int. Immunol. 2019. pii: dxz001. DOI: 10.1093/intimm/dxz001.

17. Richard C, Calder CP. Docosahexaenoic Acid. Adv Nutr. 2016; 6 (7): 1139-1141.

18. Tsurutani Y, Inoue K, Sugisawa C, et al. Increased Serum Dihomo-gamma-linolenic Acid Levels Are Associated with Obesity, Body Fat Accumulation, and Insulin Resistance in Japanese Patients with Type 2 Diabetes. Intern Med. 2018; 20 (57): 2929-2935.

19. Shahidi F, Ambigaipalan P. Omega-3 Polyunsaturated Fatty Acids and Their Health Bene ts. Annu Rev Food Sci Technol. 2018; 9: 345-381.

20. Carlson SJ, O’Loughlin AA, Anez-Bustillos L, et al. A diet with docosahexaenoic and arachidonic acids as the sole source of polyunsaturated fatty acids is suf cient to support visual, cognitive, motor, and social development in mice. Front. Neurosci. 2019; 13: 72. DOI: 10.3389/ fnins.2019.00072.

21. Stark KD, Van Elswyk ME, Higgins MR, et al. Global survey of the omega-3 fatty acids, docosahexaenoic acid and eicosapentaenoic acid in the blood stream of healthy adults. Progr. Lipid Res. 2016; 63: 132-152.

22. World Medical Association Declaration of Helsinki – Ethical Principles for Medical Research Involving Human Subjects, 2013.

23. Бичкаева Ф.А., Баранова Н.Ф., Власова О.С. [и др.] Методика измерений массовой концентрации метиловых эфиров жирных кислот (МЭЖК) в сыворотке крови методом газожидкостной хроматографии. Реестр методик измерений УрО РАН No 88-16365-001-2019, No ФР.1.31.2019.33742. [Bichkaeva FA, Baranova NF, Vlasova OS, et al. Metodika izmerenij massovoj koncentracii metilovyh e rov zhirnyh kislot (MEZhK) v syvorotke krovi metodom gazozhidkostnoj hromatogra i [Method for measuring the mass concentration of fatty acid methyl esters (FAMEs) in serum by gas-liquid chromatography] Reestr metodik izmerenij UrO RAN No 88-16365-001-2019, No FR.1.31.2019.33742 [The register of measurement methods of the Ural Branch of the Russian Academy of Sciences No 88-16365-001-2019, No FR.1.31.2019.33742]. (In Russ.)].

24. Соловьева В.А., Лейхтер С.Н., Соловьева Н.В. [и др.]. Роль насыщенных жирных кислот в нарушениях липидного обмена у пациентов с синдромом зависимости от алкоголя // Журнал неврологии и психиатрии им. С.С. Корсакова. – 2020. – No 9. – С.93–97. [Solovyova, VA, Leuchter, SN, Solovyova NV, et al. Rol’ nasyshchennyh zhirnyh kislot v narusheniyah lipidnogo obmena u pacientov s sindromom zavisimosti ot alkogolya [The role of saturated fatty acids in lipid metabolism disorders in patients with alcohol dependence syndrome] Zhurnal nevrologii I psihiatrii im. S.S. Korsakova [Journal of Neurology and Psychiatry named after S.S. Korsakov]. 2020; 9: 93-97. (In Russ.)].

25. Соловьева В.А., Лейхтер С.Н., Соловьева Н.В. [и др.]. Содержание полиненасыщенных жирных кислот у больных с синдромом зависимости от алкоголя // Наркология. – 2019. – No 8. – С.53–60. [Solovieva VA, Leichter SN, Solovieva NV, et al. Soderzhanie polinenasyshchennyh zhirnyh kislot u bol’nyh s sindromom zavisimosti ot alkogolya [The content of polyunsaturated fatty acids in patients with alcohol dependence syndrome] Narkologiya [Narkologiya]. 2019; 8: 53-60. (In Russ.)].

26. Боровик, Т.Э., Грибакин С.Г., Скворцова В.А. [и др.]. Длинноцепочечные полиненасыщенные жирные кислоты и их роль в детском питании. Обзор литературы // Вопросы современной педиатрии. – 2012. – No 4. – С.21–28. [Borovik TE, Gribakin SG, Skvortsova VA, et al. Dlinnocepochechnye polinenasyshchennye zhirnye kisloty i ih rol’ v detskom pitanii. Obzor literatury [Long chain polyunsaturated fatty acids and their role in baby food. Literature review] Voprosy sovremennoj pediatrii [Current Pediatrics]. 2012; 4: 21-28. (In Russ.)].

27. Новгородцева Т.П., Денисенко Ю.К., Антонюк М.В., Жукова Н.В. Модификация состава жирных кислот мембраны эритроцитов при хронической обструктивной болезни легких // Бюллетень Сибирского отделения Российской академии медицинских наук. – 2013. – No 5. – С.64–69. [Novgorodceva TP, Denisenko YuK, Antonyuk MV, Zhukova NV. Modi kaciya sostava zhirnyh kislot membrany eritrocitov pri hronicheskoj obstruktivnyj bolezni legkih [Modi cation of fatty acid composition of erythrocyte membrane in chronic obstructive pulmonary disease] Byulleten’ Sibirskogo otdeleniya Rossijskoj akademii medicinskih nauk [Bulletin of the Siberian Branch of the Russian Academy of Medical Sciences]. 2013; 5: 64-69. (In Russ.)].

 

UDC 618.3-06:578.834.1

DOI: 10.20969/VSKM.2022.15(6).109-116

PDF download PREGNANCY AND COVID-19. PERINATAL OUTCOMES

KHAIRULLINA GUZEL R., ORCID ID: 0000-0002-4102-8013; C. Med. S., associate professor of the Department of obstetrics and gynecology of Kazan State Medical University, Russia, 420012, Kazan, Tolstoy str., 4, e-mail: bas.gulya@mail.ru

SHUKRULLOEV NADIR R., ORCID ID: 0000-0001-5541-4460; student of Kazan State Medical University, Russia, 420012, Kazan, Tolstoy str., 4, e-mail: nadir_shuk.2011@mail.ru

DRUZHKOVA EVGENIA B., ORCID ID: 0000-0001-5283-1904; obstetrician-gynecologist of Republican Clinical Hospital, Russia, 420064, Kazan, Orenburg tract, str., 138, e-mail: evgenya.druzhkowa@yandex.ru

GALIMZYANOV ILDUS I., ORCID ID: 0000-0002-4478-0702; student of Kazan State Medical University, Russia, 420012, Kazan, Tolstoy str., 4, e-mail: bezponyatii111@gmail.com

ZHOGINA ANASTASIA S., ORCID ID: 0000-0001-7363-3392; student of Kazan State Medical University, Russia, 420012, Kazan, Tolstoy str., 4, e-mail: nastya2000ziv@mail.ru

Abstract. Introduction. The coronavirus infection COVID-19 has become a major medical problem around the world. Despite the fact that the infection is new and research on COVID-19 is ongoing, the main risk factors for severe consequences for pregnant women have already been identi ed. Aim. The aim of our study – analyze the impact of coronavirus infection and its consequences on the course of pregnancy and perinatal outcomes. Material and methods.The medical records of 4422 pregnant women were studied on the basis of the Kazan city obstetric hospital. The study included two groups: an experimental group – 67 patients who underwent COVID-19 at various times during pregnancy and a control group – 65 patients with a normal pregnancy. The analysis of the collected data was performed in the GraphPad Prism 9 software (GraphPad Software, San Diego, CA, USA). Results and discussion. Most often, pregnant women had infection COVID-19 during the third trimester, n=51 (76%). The main complications during pregnancy in the experimental group were moderate preeclampsia – 6; 9% (in the control group – 2; 3%) and the threatened preterm labor – 14; 17% (in the control group – 2; 3%). The main complications in newborns: respiratory distress syndrome (9; 13%) and intrauterine pneumonia (3; 5%). The calculated odds ratios showed that the chance of getting 7 or more points on the Apgar scale in the control group was 7,2 times higher compared to the experimental group at 1 minute, and 10,1 times higher at the fth minute. A signi cant difference (p-value=0,0027) was also shown between the average values of body weight of newborns in the experimental group [(3047±186) g] and control [(3403±243) g]. Conclusion.The number of cases of complicated pregnancy was signi cantly higher in experimental the group compared to the control group. Children in the control group are more likely to have higher Apgar score and have higher body weight than children born to mothers included in the experimental group. Also, the number of newborns with complications (mainly pathology of the respiratory system) in the early neonatal period was higher in the experimental group comparedto the control group.

Key words: COVID-19, pregnancy management, perinatal outcomes.

For reference: Khairullina GR, Shukrulloev NR, Druzhkova EB, et al. Pregnancy and COVID-19. Perinatal outcomes. The Bulletin of Contemporary Clinical Medicine. 2022; 15 (6): 109-116. DOI: 10.20969/VSKM.2022.15(6).109-116.

References

1. Методические рекомендации: организация оказания медицинской помощи беременным, роженицам, родильницам и новорожденным при новой коронавирусной инфекции COVID-19. Версия 4 (05.07.2021). – 131 c. [Metodicheskie rekomendacii: organizacia okazaniya medicinskoy pomoschi beremennym, rozhenicam i novorozhdennyh pri novoy koronavirusnoy infekcii СOVID-19 [Guidelines: organization of medical care for pregnant women, women in childbirth, puerperas and newborns with a new coronavirus infection COVID-19. Version 4 (05.07.2021); 131 (In Russ.)]. URL: https://static-0.minzdrav.gov.ru/system/attachments/ attaches/000/057/333/original/05072021_MR_Preg_ v4.pdf

2. Калиматова Д.М., Доброхотова Ю.Э. Особенности течения беременности и родов при инфекции COVID-19 // Практическая медицина. – 2020. –Т.18, No2. – С. 6–11. [Kalimatova DM, Dobrokhotov YE. Osobennosti techeniya beremennosti I rodov pri infekcii COVID-19 [Features of the course of pregnancy and childbirth during COVID-19 infection] //Prakticheskaya medicina [Practical medicine]. 2020; 18(2): 6-11. (In Russ.)]. DOI: 10.32000/2072-1757-2020-2-6-11.

3. Косолапова, Ю.А., Морозов Л.А., Инвияева Е.В. Влияние COVID-19 на исходы беременности и состояние новорожденных (обзор литературы) // Акушерство и гинекология. – 2021. – Т.9, No4. – С. 63–70. [Kosolapova YA, Morozov LA, Inviyaeva EV. Vliyanie COVID-19 na ischodi beremennosti I sostoyanie novorozhdennych (obzor literatury) [The impact of COVID-19 on pregnancy outcomes and the condition of newborns (literature review)] // Akusherstvo I ginecologiya [Obstetrics and Gynecology]. 2021; 9(4): 63-70. (In Russ.)] DOI: 10. 33029/2303-9698-2021-9-4-63-70.

4. Юпатов, Е.Ю., Мальцева Л.И., Замалеева Р.С. Новая коронавирусная инфекция COVID-19 в практике акушера-гинеколога: обзор современных данных и рекомендаций // Акушерство, гинекология и репродукция. – 2020. – Т.14, No2. – С. 148–158. [Yupatov EY, Maltseva LI, Zamaleeva RS. Novaya koronavirusnaya infekciya COVID-19 v praktike akushera-ginecologa: obzor sovremennih dannyh I recomendaciy [New coronavirus infection COVID-19 in the practice of an obstetrician-gynecologist: a review of current data and recommendations]// Akusherstvo, ginecologiya i reprodukciya [Obstetrics, Gynecology and Reproduction]. 2020; 14(2): 148-158. (In Russ.)]. DOI: 10.17749/2313-7347-2020-14-2-148-158.

5. Синчихин, С.П., Степанян Л.В, Мамиев О.Б. Новая коронавирусная инфекция и другие респираторные вирусные заболевания у беременных: клиническая лекция // Гинекология. – 2020. –Т.22, No2.– С.11. [Sinchikhin SP, Stepanyan LV, Mamiev OB. Novaya koronavirusnaya infekciya i drugie respiretornye virusnye zabolevaniya u beremennyh: klinicheskaya lekciya. [New coronavirus infection and other respiratory viral diseases in pregnant women: clinical lecture]// Ginecologiya [Gynecology]. 2020; 22(2): 11. (In Russ.)]. DOI: 10.26442/2079-5696-2020-22-2-11.

6. Eishafeey F., Magdi R., Hindi N, et al. A systematic scoping review of COVID-19 during pregnancy and childbirth. Int J. Gynaecol. Obstet. 2020. DOI: 10.1002/ijgo.13182.

7. Monteleone P.A., Nakano M., Lazar V, et al. A review of initial data on pregnancy during the COVID-19 outbreak: implications for assisted reproductive treatments. JBRA Assist. reproduction. 2020; 24(2): 219-225. DOI: 10.5935/1518-0557.20200030.

8. Zhao S., Lin Q., Ran J, et al. Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak. Int. J. Infect. Dis. 2020; 92: 214-217. DOI: 10.1016/j.ijid.2020.01.050.

9. Гурбанова Д.Ф., Гаджиева Ф.Р. Влияние COVID-19 на беременность и послеродовой период // Гинекология. – 2020. – No2. – С. 3. [Gurbanova DF, Gadzhiev FR. Vliyaniye COVID-19 na beremennost i poslerodovoy period [The impact of COVID-19 on pregnancy and the postpartum period] // Ginecologiya [Gynecology]. 2020; (2): 3. (In Russ.)]. DOI: 10.24411/2410-2865-2021-10301.

10. Yuan J, Qian H, Cao S, et al. Is there possibility of vertical transmission of COVID-19: a systematic review. Transl Pediatr. 2021; 10(2): 423-434. DOI: 10.21037/tp-20-144.

11. Knight M, Bunch K, Vousden N, et al. Characteristics and outcomes of pregnant women admitted to hospital with con rmed SARS-CoV-2 infection in UK: national population based cohort study. BMJ. 2020; 369: m2107. DOI:10.1136/bmj.m2107.

12. Kourtis AP, Read JS, Jamieson DJ. Pregnancy and infection. N Engl J Med. 2014; 370 (23): 2211-2218. DOI: 10.1056/NEJMra1213566.

13. Aghaeepour N, Ganio EA, Mcilwain D, et al. An immune clock of human pregnancy. Sci Immunol. 2017; 2(15): eaan2946. DOI:10.1126/sciimmunol.aan2946.

14. Selim M, Mohamed S, Abdo M, et al. Is COVID-19 Similar in Pregnant and Non-Pregnant Women? Cureus. 2020; 12(6): e8888. DOI:10.7759/cureus.8888.

15. Burton GJ, Redman CW, Roberts JM, et al. Pre-eclampsia: pathophysiology and clinical implications. BMJ. 2019; 366: l2381. DOI:10.1136/bmj.l2381.

16. Di Mascio D, Khalil A, Saccone G, et al. Outcome of coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis. Am J Obstet Gynecol MFM. 2020; 2(2):100-107. DOI: 10.1016/j.ajogmf.2020.100-107

17. Wastnedge EAN, Reynolds RM, van Boeckel SR, et al. Pregnancy and COVID-19. Physiol Rev. 2021; 101(1): 303-318. DOI: 10.1152/physrev.00024.2020.

18. Stoecklein S, et al. Effects of SARS-CoV-2 on prenatal lung growth assessed by fetal MR. The Lancet. Respiratory medicine. 2022; 10(4): e36-e37. DOI :10.1016/S2213-2600(22)00060-1.

19. Shanes ED. Placental pathology in COVID-19 (Pre-print). MedRxiv 20093229 2020. DOI: 10.1101/ 2020.05.08.20093229.

 

UDC 616.37-002.1-08+616.15-07

DOI: 10.20969/VSKM.2022.15(6)117-121

PDF download ENDOTELIAL DISFUNCTION IN ASSESSING OF SEVERITY OF ACUTE PANCREATITIS

KHALIMOV EDUARD V., ORCID ID: 0000-0001-6274-4310; D. Med. Sci., professor of the Department of general surgery of Izhevsk State Medical Academy, Russia, 426034, Izhevsk, Kommunar str., 281, 29, tel. 8-912-451-82-80, e-mail: ob.hirurgiy21@mail.ru

MIKHAJLOV ALEXANDER YU., ORCID ID: 0000-0002-9368-8021; C. Med. Sci., associate professor of the Department of general surgery of Izhevsk State Medical Academy, Russia, 426034, Izhevsk, Kommunar str., 281, tel. 8-912-748-89-19, e-mail: dr.alexandrmich@gmail.com

SOLOVIEV ALEXANDER A., ORCID ID: 0000-0001-5787-8269; C. Med. Sci., associate professor of the Department of histology, embryology and cytology of Izhevsk State Medical Academy, Russia, 426034, Izhevsk, Kommunar str., 281, tel. 8-912-466-31-25, e-mail: solcyto@udm.ru

STYAZHKINA SVETLANA N., ORCID ID: 0000-0001-5787-8269; D. Med. Sci., professor of the Department of surgery of Izhevsk State Medical Academy, Russia, 426034, Izhevsk, Kommunar str., 281, tel. 8-950-820-51-10, e-mail: sstazkina064@gmail.com

VASILIEVA ANNA M., ORCID ID: 0000-0001-7883-4935; student of Faculty of medicine of Izhevsk State Medical Academy, Russia, 426034, Izhevsk, Kommunar str., 281, tel. 8-919-917-81-15, e-mail: annavasilieva205@gmail.com

NESTEROV BORIS V., ORCID ID: 0000-0002-8876-5205; student of Faculty of medicine of Izhevsk State Medical Academy, Russia, 426034, Izhevsk, Kommunar str., 281, tel. 8-919-918-32-36, e-mail: nesterovym@yahoo.com

Abstract. Introduction. The questions of the ef cacy estimation of the treatment carried out at various forms of acute pancreatitis and the choice of the optimal terms of surgical treatment are still debatable. The given work is an attempt to nd effective indications for the adequate treatment of patients with this pathology. Aim. Aim is to estimate the numberof desquamated peripheral blood endothelial cells and degree of their coloring in patients with acute pancreatitis in the dynamics of the disease. Material and methods. We studied desquamated endothelial cells in 22 patients divided into 2 groups: group A – with acute edematous pancreatitis, and group B – with acute destructive pancreatitis with surgical treatment. We were studied the dynamics of the number of desquamated peripheral blood endothelial cells and degree of their coloring in both ways of treatment and their compliance with the scales that shows the severity of the disease.Results and discussion. In group A patients on day 7–9 while clinical and laboratory parameters of acute pancreatitis was decreased we noticed that the number of desquamated endothelial cells was decreased in the eld of vision from 8 to 4,7. In group B the increasement of the parameters of the scales of criteria for acute pancreatitis and leukocyte intoxication has the same result – number of cells in the eld of vision were decreased from 195 to 50. This patterns of the dynamics of the intensity of coloring of desquamated endothelial cells in both groups are re ected in the coloring coef cient, that was made by our study group. We found that in group A the color coef cient decreases from 1,5 to 0,2 (hyperchromically colored cells prevail), and in group B the coef cient increases from 0,8 to 1,2 (hypochromically colored cells increased). Conclusion. The study of the degree of endotheliocyte staining, re ecting the compensatory possibilities of the organism and treatment ef cacy, is of great importance in the assessment of the severity and prognosis of acute pancreatitis treatment. An increasment of the color coef cient of desquamated endothelial cells by 0,4 may indicate that it’s time for surgical methods of treatment.

Key words: pancreatitis, acute pancreatitis, desquamated endotheliocytes, severity, endothelial disfunction.

For references: Khalimov EV, Mikhailov AY, Solov’ev AA, et al. Endotelial disfunction in assessing of severity of acute pancreatitis. The Bulletin of Contemporary clinical medicine. 2022; 15(6): 117-121. DOI: 10.20969/VSKM.2022.15(6).117-121.

References

1. Клинические рекомендации: острый панкреатит // Министерство здравоохранения Российской Федерации. – 2019. – С.6. [Clinicheskye recomendacii: ostryi pancreatit [Clinical guidelines: acute pancreatitis]. Ministerstvo zdravoohranenya Rossiskoy Federacii [Ministry Healthcare of the Russian Federation]. 2019; 6 (In Russ.)]. URL: https://diseases.medelement.com/disease

2. Dulce M, Taxonera C, Giner M. Update on pathogenesis and clinical management of acute pancreatitis. Word J Gastrointenstinal Pathophysiol. 2012; 3(3): 60-70. DOI: 10.4291/wjgp.v3.i3.60.

3. Отдельнов Л.А., Мухин А.С. Абдоминальный компартмент – синдром при тяжелом остром панкреатите // Вестник хирургии. – 2020. – No 2.– С.73–78. [Otdel’nov LA, Muhin AS. Abdominal’nyj kompartment – sindrom pri tyazhelom ostrom pankreatite [Abdominal compartment – a syndrome in severe acute pancreatitis]. Vestnik hirurgii [Bulletin of Surgery]. 2020; 2: 73-78. (In Russ.)]. DOI: 10.24884/0042-4625-2020-179-2-73-78.

4. Авакимян С.В., Авакимян В.А., Дидигов М.Т., Бабенко Е.С. Выбор метода лечения острого панкреатита в зависимости от прогноза течения заболевания // Вестник хирургии. – 2016. – No 1 – С.37–41. [Avakimyan SV, Avakimyan VA, Didigov MT, Babenko ES. Vybor metoda lecheniya ostrogo pankreatita v zavisimosti ot prognoza techeniya zabolevaniya [The choice of treatment for acute pancreatitis depending on the prognosis of the course of the disease]. Vestnik hirurgii [Bulletin of Surgery] 2016; 1: 37-41. (In Russ.)]. DOI: 616.37-002-08:616-037.

5. Kokosis G, Perez A, Pappas TN. Surgical management of necrotizing pancreatitis: an overview. World J Castroenterol. 2014; 20(43): 1606-1611. DOI: 10.3748/ wjg.v20.i43.16106.

6. Greenberg JA. Clinical practice guideline: management of acute pancreatitis. Сanadian Journal of Surgery. 2016; 59(2): 128. DOI: 10.1503/cjs.015015.

7. Freeman ML. Interventions for necrotizingn pacreatitis. Summary of multidisciplinary consensus conference pancreas. 2012; 1776-1194. DOI: 10.1097/ MPA.0b013e318269c660.

8. Чекасов В.А., Щекотова А.П., Латышева С.Э., Загородских Е.Б. Новые возможности прогнозирования ослож-нений острого панкреатита и оценка эффективности лечения // Пермский медицинский журнал. – 2013. – Т. 30, No 2. – С.10–15. [Chekasov VA, Shchyokotova AP, Latysheva SE, Zagorodskih EB. Novye vozmozhnosti prognozirovaniya oslozhnenij ostrogo pankreatita i ocenki effektivnosti lecheniya [New possibilities for predicting the complications of acute pancreatitis and evaluating the effectiveness of treatment]. Permskij medicinskij zhurnal [Perm medical journal]. 2013; 30(2): 10-15. (In Russ.)]. DOI: 616.37-002-036.11-06-037-08.

9. Тарасенко В.С. Патоморфологические механизмы развития острого панкреатита // Инноватика и экспертиза. – 2016. – No 3(18) – С.175–183. [Tarasenko VS. Patomorfologicheskie mekhanizmy razvitiya ostrogo pankreatita [Pathomorphological mechanisms of development of acute pancreatitis]. Innovatika i ekspertiza [Innovation and expertise]. 2016; 3(18): 175-183. (In Russ.)]. URL: https://www.elibrary.ru/ item.asp?id=29032671

10. Малкова О.Г., Медведева С.Ю., Лейдерман И.Н., Левит А.Л. Некоторые аспекты патогенеза системной воспалительной реакции у больных с неотложной хиругической патологией органов брюшной полости (воспаление, сепсис и сосудистая проницаемость) // Вестник уральской медицинской академической науки. – 2009. – No 3. – С.92–95. [Malkova OG, Medvedeva SYu, Lejderman IN, Levit AL. Nekotorye aspekty patogeneza sistemnoj vospalitel’noj reakcii u bol’nyh s neotlozhnoj hirugicheskoj patologiej organov bryushnoj polosti (vospalenie, sepsis i sosudistaya pronicaemost’) [Some aspects of the pathogenesis of systemic inflammatory response in patients with urgent surgical pathology of the abdominal organs (inflammation, sepsis and vascular permeability)]. Vestnik ural’skoj medicinskoj akademicheskoj nauki [Bulletin of the Ural Medical academic science]. 2009; 3: 92-95 (In Russ.)]. URL: https://www.elibrary.ru/item. asp?id=12877521

11. Васина Л.В., Власов Т.Д., Петрищев Н.Н. Функциональная гетерогенность эндотелия (обзор) // Артериальная гипертензия. – 2017. – Т. 23, No 2. – С.88–102. [Vasina LV, Vlasov TD, Petrishchev NN. Funkcional’naya geterogennost’ endoteliya (obzor) [Functional heterogeneity of the endothelium (review)]. Arterial’naya gipertenziya [Arterial hypertension]. 2017; 23(2): 88-102. (In Russ.)]. DOI: 10.18705/1607-419X2017-23-2-88-102.

12. Куликов Д.В. Корольков А.Ю., Морозов В.П., Ваганов А.А. Нерешенные вопросы лечения острого деструктивного панкреатита // Вестник экспериментальной и клинической хирургии. – 2019. – Т. 12, No 2. – С.134–140. [Kulikov DV, Korol’kov AYu, Morozov VP, Vaganov AA. Nereshennye voprosy lecheniya ostrogo destruktivnogo pankreatita [Unresolved issues in the treatment of acute destructive pancreatitis]. Vestnik eksperimental’noj i klinicheskoj hirurgii [Bulletin of experimental and clinical surgery]. 2019; 12(2): 134-140. (In Russ.)]. URL: https://www.researchgate. net/publication/336426531_Unresolved_issues_of_ treatment_of_the_early_phase_of_acute_destructive_ pancreatitis/fulltext/5da07cd9a6fdcc8fc3476c3f/ Unresolved-issues-of-treatment-of-the-early-phase-of-acute-destructive-pancreatitis.pdf

13. Минеев Д.А., Самарцев В.А. Возможности определения эндотелиальной дисфункции при различных формах острого панкреатита с помощью ультразвуковой допплерографии // Здоровье семьи – XXI век. – 2018. – No 1. – С.41–42. [Mineev DA, Samarcev VA. Vozmozhnosti opredeleniya endotelial’noj disfunkcii pri razlichnyh formah ostrogo pankreatita s pomoshch’yu ul’trazvukovoj doplerogra i [Possibilities for determining endothelial dysfunction in various forms of acute pancreatitis using Doppler ultrasound]. Zdorov’e sem’i XXI vek [Health of the family 21st century]. 2018; 1: 41-42. (In Russ.)]. URL: https://www.elibrary.ru/item.asp?id=35186224

14. Загородских Е.Б. Показатели повреждения эндотелия и хирургическая тактика при остром панкреатите тяжелого течения: диссертация на соискание ученой степени кандидата медицинских наук. – Пермь, 2014. [Zagorodskih EB. Pokazateli povrezhdeniya endoteliya i hirurgicheskaya taktika pri ostrom pankreatite tyazhelogo techeniya [Indicators of endothelial damage and surgical tactics in severe acute pancreatitis]. Dissertaciya k. m. n. Perm’ [Dissertation Ph.D. Perm]. 2014. (In Russ.)]. URL: https://www.psma.ru/index.php?option=com_ mtree&task=att_download&link_id=27&cf_id=24

15. Овсяник Д.М. Диагностика инфицированного панкреонекроза на основании оценки показателей эндотелиальной дисфункции // Новости хирургии. – 2014. – Т. 22, No 4. – С.428–435. [Ovsyanik DM. Diagnostika inficirovannogo pankreonekroza na osnovanii ocenki pokazatelej endotelial’noj disfunkcii [Diagnosis of infected pancreatic necrosis based on the assessment of indicators of endothelial dysfunction]. Novosti hirurgii [News of Surgery]. 2014; 22(4): 428-435. (In Russ.)]. URL: https:// cyberleninka.ru/article/n/diagnostika-in tsirovannogopankreonekroza-na-osnovanii-otsenki-pokazateley-endotelialnoy-disfunktsii/viewer

16. Халимов Э.В., Михайлов А.Ю., Тихомирова Г.И., Майбуров В.В. Плазменный нерасщепленный фибронектин в оценке тяжести острого панкреатита // Современные проблемы науки и образования. – 2019. – No 3. – С.139. [Halimov EV, Mihajlov AY., Tihomirova GI, Majburov VV. Plazmennyj nerasshcheplennyj bronektin v ocenke tyazhesti ostrogo pankreatita [Plasma uncleaved bronectin in assessing the severity of acute pancreatitis]. Sovremennye problemy nauki i obrazovaniya [Modern problems of science and education]. 2019; 3: 139. (In Russ.)]. URL: https://science-education.ru/ru/article/ view?id=28892

17. Иванова Р.Ю., Муллахметов Б.А., Угланова Л.Н. Эндотелиальная дисфункция у больных с острым панкреатитом // Современные аспекты медицины и биологии: материалы VIII Межрегиональной межвузовской научно-практической конференции молодых ученых и студентов. – Ижевск, 2019. – С.94–95. [Ivanova RU, Mullakhmetov BA, Uglanova LN. Endotelial’naya disfunkciya u bol’nyh s ostrym pankreatitom [Endothelial dysfunction in patients with acute pancreatitis]. Materialy VIII Mezhregional’noj mezhvuzovskoj nauchno-prakticheskoj konferencii molodyh uchenyh i studentov, Izhevsk [Modern aspects of medicine and biology: materials of the 8th Interregional Interuniversity Scienti c and Practical Conference of Young Scientists and Students, Izhevsk]. 2019; 94-95. (In Russ.)] URL: https:// scirate.1spbgmu.ru/SciRateSMUWeb/attachments/13455/ SciProduct/24822/2019_Sovremennye_aspekty_ meditsiny_i_biologii.pdf

 

UDC 616-001-031.82-06:616-036.88:614.29

DOI: 10.20969/VSKM.2022.15(6).122-126

PDF download ANALYSIS OF THE LETHALITY OF POLYTRAUMA IN MULTIDISCIPLINE HOSPITAL

CHIKAEV VYACHESLAV F., ORCID ID: 0000-0002-4135-0387; D. Med. Sci., professor of the Department of traumatology, orthopedics and emergency surgery of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. 8-927-434-48-29, e-mail: prof.chikaev@gmail.com

AKHTYAMOV ILDAR F., ORCID ID: 0000-0002-4910-8835; D. Med. Sci., professor, the Head of the Department of traumatology, orthopedics and emergency surgery of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. +7-905-315-01-50, e-mail: yalta60@mail.ru

PETUKHOV DENIS M., ORCID ID: 0000-0002-5946-2950; surgeon of Kazan Municipal Clinical Hospital No 7, Russia, 420103, Kazan, 54, Chuikov str., tel. +7-917-276-89-76, e-mail petuhoff@gmail.com

DELYAN ARTUR M., ORCID ID: 0000-0003-4918-9759; Chief Physician of Kazan Municipal Clinical Hospital No 7, Russia, 420103, Kazan, Chuikov str., 54, tel. +7 (843) 221-39-83, e-mail: gkb7@bk.ru

SADRIEV RAFAT R., ORCID ID: 0000-0003-1079-8047; D. Med. Sci., Chief anesthesiology and resuscitation specialist of Kazan Municipal Clinical Hospital No 7, Russia, 420103, Kazan, Chuikov str., 54, tel. +7-917-289-95-83, e-mail: dr-sadriev@mail.ru

ISMAGILOV DAMIR O., ORCID ID: 0000-0003-3045-7346; neurosurgeon of Kazan Municipal Clinical Hospital No 7, Russia, 420103, Kazan, Chuikov str., 54, tel. +7-927-433-28-11, e-mail: meg1205@mail.ru

Abstract. Introduction. Severe concomitant trauma is one of the most dif cult problems of modern medicine due to high mortality. The analysis of the structure of lethality and its causes can help to improve the effectiveness of care for combined trauma. Aim. The aim was to analyze the causes of mortality of patients with combined injuries in a multidisciplinary hospital of level 3. Material and methods. We studied the nature of injuries and the causes of death of 117 patients with fatal polytrauma hospitalized in the city municipal hospital No 7 in Kazan. The severity of the patients’ condition, the features of anatomical injuries, the causes, the nature of complications, depending on the duration of mortality, were studied. Results and discussion. In the structure of injuries in the patients with polytrauma and fatal outcome, the leading one was craniocerebral trauma 73,5% (n=86). Of these, 76,7% (n=66) cases were diagnosed with severe brain contusion. Injury scale was 28,5±8,4. The second position among the injuries was occupied by a chest injury, 57,2% (n=67). Injuries of the musculoskeletal system were characterized by severe and moderate traumas, injury scale was 4–9 points. Abdominal trauma was detected in 18,8% (n=22) cases. In the patients, due to the impact of mechanical damage, blood loss, peripheral and central respiratory disorders in the early post-traumatic period, central hemodynamic disorders, hypovolemia, we see developing hypoxia in most of the tissues. All this leads to a cascade pathogenetic process and is characterized by hypothermia, metabolic and metabolic disorders, hypocoagulation. Conclusion. Themain cause of death of patients with combined trauma is severe mechanical damage, excessive afferent nociceptive impulses, accompanied by a breakdown of the compensatory capabilities. Blood loss leads to perfusion disorders, coagulopathy, hemic hypoxia, and irreversible changes in the tissues. Severe brain contusion, chest trauma intensify hypoxia due to central and peripheral respiratory disorders. At late period, the cause of death is multiple organ failure and related complications.

Key words: combined injury, blood loss, hypoxia, lethality.

For referenсe: Chikaev VF, Akhtyamov IF, Petukhov DM, et al. Analysis of the lethality of victims of polytrauma in a multidisciplinary hospital. The Bulletin of Contemporary Clinical Medicine. 2022; 15(6): 122-126.DOI: 10.20969/VSKM.2022.15(6).122-126.

References

1. Агаджанян В.В., Кравцов С.А., Железнякова И.А. [и др.]. Интеграция критериев степени тяжести политравмы с международной классификацией болезни // Политравма. ‒ 2014. – No 1. – С. 6–14. [Agadzhanyan VV, Kravtsov SA, Zheleznyakova IA. Integraciya kriteriev stepeni tyazhesti politravmy s mezhdunarodnoj klassi kaciej bolezni [Integration of criteria for the severity of polytrauma with the international classi cation of the disease ]. Politravma [Polytrauma]. 2014; 1: 6-14. (In Russ.)].

2. Евдокимов Е.А. Неотложная медицина как основа совершенствования оказания медицинской помощи пострадавшим в дорожно-транспортных происшествиях // Неотложная медицина в мегаполисе: тезисы докладов междунар. форума. – Москва: ГЕОС, 2006. ‒ С. 78–80. [Evdokimov EA. Neotlozhnaya medicina kak osnova sovershenstvovaniya okazaniya medicinskoj pomoshchi postradavshim v dorozhno-transportnyh proisshestviyah [Emergency medicine as a basis for improving the provision of medical care to victims of road traf c accidents] // Neotlozhnaya medicina v megapolise: tezisy doklfdov mezhd. foruma [Abstracts of the report. int. Forum «Emergency Medicine in the Metropolis»]. Moscow: GEOS. 2006; 78-80. (In Russ.)].

3. Коробушкин Г.В., Шигеев С.В., Жуков А.И. Анализ причин смерти в выборке пациентов с политравмой в Москве // Политравма. – 2020. ‒ No 2. – С. 47–53. [Korobushkin GV, Shigeev SV, Zhukov AI. Analiz prichin smerti v vyborke pacientov s politravmoj v Moskve [Analysis of the causes of death in a sample of patients with polytrauma in Moscow]. Politravma [Polytrauma]. 2020; 2: 47-53. (In Russ.)]. DOI: 10.24411/1819-1495-2020-10019.

4. Левченко Т.В., Кравцов С.А., Корнев А.Н. [и др.]. Анализ госпитальной летальности и качества клинической диагностики пострадавших с политравмой// Политравма. – 2014. ‒ No 3. – С. 24–32. [Levchenko TV, Kravtsov SA, Kornev AN, et al. Analiz gospital’noj letal’nosti i kachestva klinicheskoj diagnostiki postradavshih s politravmoj [Analysis of hospital mortality and the quality of clinical diagnostics of patients with polytrauma]. Politravma [Polytrauma]. 2014; 3: 24-32. (In Russ.)].

5. Алексанин С.С., Гудзь Ю.В., Рыбников В.Ю. Концепция и технологии организации оказания медицинской помощи пострадавшим в чрезвычайных ситуациях с травмами силами и средствами МЧС России. ‒ Санкт-Петербург: Политехника Сервис, 2019. ‒ 200 с. [Aleksanin SS, Gudz VY, Rybnikov VY. Koncepciya i tekhnologii organizacii okazaniya medicinskoj pomoshchi, postradavshim v chrezvychajnyh situaciyah s travmami silami i sredstvami MChS Rossii [The concept and technologies of organizing the provision of medical assistance to victims in emergency situations with injuries by the forces of the EMERCOM of Russia]. SPb.: Politekhnika Servis [St. Petersburg: Polytechnic Service]. 2019; 200 (In Russ.)].

6. Агаджанян В.В., Кравцов С.А, Шаталин А.В. Госпитальная летальность при политравме и основные направления ее снижения // Политравма. ‒ 2015. ‒ No 1. – С. 6–15. [Agadzhanyan VV, Kravtsov SA, Shatalin AV, et al. Gospital’naya letal’nost’ pri politravme i osnovnye napravleniya eyo snizheniya [Hospital mortality in polytrauma and the main directions of its reduction]. Politravma [Polytrauma]. 2015; 1: 6-15. (In Russ.)].

7. Багненко С.Ф. Скорая медицинская помощь: клинические рекомендации. – Москва: ГЭОТАР-Медиа, 2019. ‒ С. 623–670. [Bagnenko SF. Skoraya medicinskaya pomoshch’: Klinicheskie rekomendacii [Ambulance: Clinical guidelines]. Moscow: GEOTAR-Media, 2019; 623-670. (In Russ.)].

8. Назаров И.П. Интенсивная терапия критических состояний (лекционный курс): [монография]. ISBN 978-5-222-10494-1. ‒ 2007. – 608 с. [Nazarov I.P. Intensivnaya terapiya kriticheskih sostoyanij (lekcionnyj kurs): [monogra ya]. [Intensive therapy of critical conditions (lecture course): [monograph].ISBN 978-5-222-10494-1. 2007; 608. (In Russ.)].

9. Багненко С.Ф., Стожаров В.В., Мирошниченко А.Г. Госпитализация как показатель работы службы скорой медицинской помощи // Скорая медицинская помощь. ‒
2005. ‒ No 3. – C. 9–14. [Bagnenko SF, Stozharov VV, Miroshnichenko AG, et al. Gospitalizaciya kak pokazatel’ raboty sluzhby skoroj medicinskoj pomoshchi [Hospitalization as an indicator of the work of the ambulance service] // Skoraya medicinskaya pomoshch’ [Ambulance]. 2005; 3: 9-14. (In Russ.)].

10. Бондаренко А.В., Герасимова О.А., Лукьянов В.В. [и др.]. Состав, структура повреждений, летальность и особенности оказания помощи пострадавшим на этапах лечения политравмы // Политравма. ‒ 2014. ‒ No 1. – С. 15 –21. [Bondarenko AV, Gerasimova OA, Lukyanov VV, et al. Sostav, struktura povrezhdenij, letal’nost’ i osobennosti okazaniya pomoshchi, postradavshim na etapah lecheniya politravmy [Composition, structure of injuries, mortality and peculiarities of rendering assistance to victims at the stages of treatment of polytrauma]// Politravma [Polytrauma]. 2014; 1: 15-21. (In Russ.)].

11. Колтович А., Пфейфер Р., Ивченко Д., Алмахмауд Х. Хирургический метод «Damage control» в мирных и военных условиях // Политравма. ‒ 2014. ‒ No 4. – С. 6‒15. [Koltovich A., Pfeifer R, Ivchenko D, Almakhmaud H. Hirurgicheskij metod «Damage control» v mirnyh i voennyh usloviyah [Surgical method «Damage control» in peaceful and military conditions] // Politravma [Polytrauma]. 2014; 4: 6-15. (In Russ.)].

12. Чепурных Е.Е., Григорьев В.Г. Сочетанные повреждения печени // Бюллетень ВЦНС СО РАМН. ‒ 2005. ‒ No 3 (41). ‒ С. 177‒180. [Chepurnykh EE, Grigoriev VG. Sochetannye povrezhdeniya pecheni [Combined liver damage] // Byulleten’ VCNS SO RAMN. [Bulletin of VTSNS SB RAMS]. 2005; 3 (41): 177-180. (In Russ.)].

13. Устьянцева И.М., Хохлова О.И., Петухова О.В. [и др.]. Прогностическая значимость маркеров воспаления, липополисахаридсвязывающего протеина и лактата в развитии сепсиса у пациентов с политравмой // Политравма. ‒ 2014. ‒ No 3. ‒ C. 15‒23. [Ustyantseva IM, Khokhlova OI, Petukhova OV. Prognosticheskaya znachimost’ markyorov vospaleniya, lipopolisaharid svyazyvayushchego proteina i laktata v razvitii sepsisa u pacientov s politravmoj. [Prognostic signi cance of in ammation markers, lipopolysaccharide binding protein and lactate in the development of sepsis in patients with polytrauma] // Politravma [Polytrauma]. 2014; 3: 15-23. (In Russ.)].

14. Lier H, Krep H, Schroeder S, Stuber F. Preconditions of hemostasis in trauma: a review. The in uence of acidosis, hypocalcemia, anemia, and hypothermia on functional hemostasis in trauma. J. Trauma. 2008; 65: 951-960. DOI: 10.1097/TA.0b013e318187e15b.

15. Dirkmann D, Hanke A, Gorlinger K, Peters J. Hypothermia and acidosis synergistical impair coagulation in human whole blood. Anesth. Analg. 2008; 106: 1627-1632. DOI: 10.1213/ane.0b013e31817340ad.

16. Hess JR, Brohi K, Dutton RP, et al. The coagulopathy of trauma: a review of mechanisms. J. Trauma. 2008; 65: 748-754. DOI: 10.1097/TA.0b013e3181877a9c.

17. Чикаев В.Ф., Ахтямов И.Ф., Зиатдинов Б.Г., Галяутдинов Ф.Ш. Организационные аспекты работы противошоковой палаты приемного отделения при госпитализации пострадавших с политравмой // Политравма. ‒ 2017. ‒ No 3. ‒ С. 6‒11. [Chikaev VF, Akhtyamov IF, Ziatdinov BG, Galyautdinov FS. Organizacionnye aspekty raboty protivoshokovoj palaty priemnogo otdeleniya pri gospitalizacii postradavshih s politravmoj [Organizational aspects of the work of the anti-shock ward of the emergency department during hospitalization of patients with polytrauma]// Politravma [Polytrauma]. 2017; 3: 6-11. (In Russ.)].

 

REVIEWS

UDC 616.5-089.844:617.52-001.17-031.82

DOI: 10.20969/VSKM.2022.15(6).127-132

PDF download ANALYSIS OF SKIN GRAFTING METHODS FOR EXTENSIVE BURNS OF THE MIDDLE AND LOWER THIRD OF THE FACE

PAVLYUCHENKO SERGEY V., ORCID ID:0000-0003-3138-5452; C. Med. Sci., associate professor of the Department of specialized surgical disciplines of the Voronezh State Medical University named after N.N. Burdenko, Russia, 394036, Voronezh, Studentskaya str., 10, tel. 8-473-257-97-17, e-mail: pavl-ortoped@rambler.ru

POPOV KONSTANTIN V., ORCID ID: 0000-0001-6258-7941; postgraduate student of the Department of specialized surgical disciplines of the Voronezh State Medical University named after N.N. Burdenko, Russia, 394036, Voronezh, Studentskaya str., 10, tel.8-920-212-34-01, e-mail: slayer111@list.ru

ZHDANOV ALEXANDER I., ORCID ID: 0000-0001-7110-6249; C. Med. Sci., professor of the Department of specialized surgical disciplines of the Voronezh State Medical University named after N.N. Burdenko, Russia, 394036, Voronezh, Studentskaya str., 10, tel.8-473-257-97-17, e-mail: alexzhdanov23@rambler.ru

BULYNIN VIKTOR V., ORCID ID: 0000-0003-3447-1129; C. Med. Sci., professor of the Department of specialized surgical disciplines of the Voronezh State Medical University named after N.N. Burdenko, Russia, 394036, Voronezh, Studentskaya str., 10, tel.8-473-257-97-17, e-mail: specsurg@vrngmu.ru

PARKHISENKO YURI A., ORCID ID: 0000-0001-7400-5013; C. Med. Sci., professor of the Department of specialized surgical disciplines of the Voronezh State Medical University named after N.N. Burdenko, Russia, 394036, Voronezh, Studentskaya str., 10, tel.8-473-257-97-17, e-mail: specsurg@vrngmu.ru

RIASNIANSKAIA LIDIA V., ORCID ID: 0000-0002-8021-7298; 6th year student of the Voronezh State Medical University named after N.N. Burdenko, Russia, 394036, Voronezh, Studentskaya str., 10, tel. 8-951-871-12-93, e-mail:lilir.v@yandex.ru

Abstract. Introduction. The article analyzes the most advanced approaches to the choice of plastic replacement of burn defects in the middle and lower thirds of the face and neck. Aim. The aim is to review of current data on the analysis of autograft transplantation technique and algorithm depending on the speci c surgical school. Material and methods.A review of current medical publications in foreign literature for the last 5 years has been carried out. Results anddiscussion. Further prospects for the use of allogeneic and synthetic materials, which are auxiliary tools necessary to optimize the technology of skin graft engraftment, are evaluated. A comparative assessment of the methods in which skin grafts were used with methods based on the use of free skin aps and local aps, previously expanded with a tissue expander, was made. Conclusion. According to the literature, the most suitable aps for face transplantation have been identi ed, depending on the aesthetic aspects of the initial defect and the anatomical features of the blood supply sources of both the donor zone and the recipient bed. In connection with recent advances in the eld of allotransplantation of the face, which marks the beginning of a new period in reconstructive surgery of the face, signi cant shortcomings and, at the same time, undoubted advantages of this technique have been noted.

Key words: skin graft, free ap, tissue expansion, burn defect of the face.

For references: Pavlyuchenko SV, Popov KV, Zhdanov AI, et al. Analysis of skin grafting methods for extensive burns of the middle and lower third of the face. The Bulletin of Contemporary Clinical Medicine. 2022; 15(6):127-132. DOI:10.20969/VSKM.2022.15(6).127-132.

References

1. Lalloué C, Aimard R, Vincent L, et al. Stratégie de prise en charge initiale des brûlures de la face: à propos de 3 cas Long-term strategy of the initial management of facial burns: About 3 cases. Ann Chir Plast Esthet. 2019; 64: 112-119.

2. Schulz A, Shoham Y, Rosenberg L, et al. Enzymatic versus traditional surgical debridement of severely burned hands: a comparison of selectivity, ef cacy, healing time, and three-month scar quality. J Burn Care Res. 2017; 38(4): 745-755.

3. Hirche C, Citterio A, Hoeksema H, et al. Eschar removal by bromelain based enzymatic debridement in burns: a European consensus. Burns. 2017; 43 (8): 1640-1653.

4. Zhang W, Xie WG, Zhang WD, et al. Expanded aps with vascular anastomosis for the treatment of scar contracture deformities of extensively burned patients. Zhonghua Shao Shang Za Zhi. 2019; 35 (6): 410-416. DOI: 10.3760/cma.j.issn.1009-2587.2019.06.003.

5. Chen B, Song H, Xu M, Gao Q. Reconstruction of cica-contracture on the face and neck with skin flap and expanded skin ap pedicled by anterior branch of transverse cervical artery. J of cranial maxillo facial surgery 2016; 44: 1280-1286.

6. Chang SS, He CN, Tang XJ, et al. Effect of perforator ap of the proper digital artery of the ulnar or radial side of nger in the treatment of webbed scar contracture of the same finger in child. Zhonghua Shao Shang Za Zhi. 2019; 35 (5): 356-361. DOI: 10.3760/cma.j.is sn.1009-2587.2019.05.006.

7. Song H, Chai J. Pre-expanded Transverse Cervical Artery Perforator Flap. Clin Plast. 2017; 44 (1): 41-47. DOI: 10.1016/j.cps.2016.08.002.

8. Wang J, Wu J, Xu M, et al. A comprehensive reconstruction strategy for moderate to severe faciocervical scar contractures.Lasers Med Sci. 2021; 36(6): 1275-1282. DOI: 10.1007/s10103-020-03178-w.

9. Kwon SH, Barrera JA, Noishiki C, et al. Current and Emerging Topical Scar Mitigation Therapies for Craniofacial Burn Wound Healing.Front Physiol. 2020; 29(11): 916. DOI: 10.3389/fphys.2020.00916.

10. Khali an S, Brazio PS, Mohan R, et al. Facial transplantation: the rst 9 years. Lancet. 2016; 384(9960): 2153-2163.

11. Norbert P, Timm WP: Moving forwards: the anterior supraclavicular artery perforator (a-SAP) ap: a new pedicled or free perforator ap based on the anterior supraclavicular vessels. J Plast Reconstr Aesthet Surg. 2013; 66: 489-496.

12. Akita S, Hayashida K, Takaki S, et al. The neck burn scar contracture: a concept of effective treatment. Burns Trauma. 2017; 5: 22. DOI: 10.1186/s41038-017-0086-8. eCollection 2017.

13. Giordano L, Santo DiD, Bondi S, et al. The supraclavicular artery island flap (SCAIF) in head and neck reconstruction: an Italian multi-institutional experience.Acta Otorhinolaryngol Ital. 2018; 38 (6): 497-503. DOI:10.14639/0392-100X-1794.

14. Hern n A. Aguilar MD, Horacio F. Mayer. A new method for securing dermal substitutes and skin grafts to dif cult portions of the face using a custom 3D-printed facemask. J of American Burns Associations. 2019; 124: 115-123.

15. Yamakawa S, Hayashida K. Advances in surgical applications of growth factors for wound healing.Burns Trauma. 2019; 7: 10. DOI: 10.1186/s41038-019-0148-1.

16. Rashid M, Zia-Ul-Islam M, Sarwar SU, Bhatti AM. The ‘expansile’ supraclavicular artery ap for release of post-burn neck contractures. J Plast Reconstr Aesthet Surg. 2006; 59: 1094-1101.

17. Telang P, Jagannathan M, Devale M. A study of the use of the supraclavicular artery ap for resurfacing of head, neck, and upper torso defects. Indian J Plast Surg. 2009; 42(1): 4-12.

18. Kadam KS, Bagal RP, Angane AY, et al. A Cross-Sectional Study of Quality of life, Psychiatric Illness, Perceived Social Support, Suicidal Risk and Selfesteem among patients with burns. J Family Med Prim Care. 2021; 10(1): 432-438. DOI: 10.4103/jfmpc.jfmpc_1604_20.

19. Du Y, Lv GZ, Yu S, et al. Long-term medical treatment of patients with severe burns at exposed sites. World J Clin Cases. 2020; 8(16): 3515-3526. DOI: 10.12998/wjcc.
v8.i16.3515.

20. Kanapathy M, Mosahebi A. Comparative study on the donor site aesthetic outcome between epidermal graft and split-thickness skin graft. Int Wound J. 2019; 16(2): 354-359. DOI: 10.1111/iwj.13039. Epub 2018 Nov 15.

21. Legemate CM, Lucas Y, Oen I, van der Vlies CH. Regrafting of the Split-Thickness Skin Graft Donor-Site: Is It Bene cial? J Burn Care Res. 2020; 41(1): 211-214. DOI: 10.1093/jbcr/irz166.

22. Kanapathy M, Bystrzonowski N, Hachach-Haram N, et al. Lower donor site morbidity and higher patient satisfaction with epidermal grafting in comparison to split thickness skin grafting: A randomized controlled trial. J Plast Reconstr Aesthet Surg. 2020; 73(8): 1556-1564. DOI: 10.1016/j. bjps.2020.03.006.

23. Ucak M. A strong reconstruction option for tissue loss on hand and wrist due to firearm injury in the Syrian war: Reverse posterior interosseous flap. Medicine. 2021; 100(32): 26816. DOI: 10.1097/ MD.0000000000026816.

24. Kanapathy M, Hachach-Haram N, Bystrzonowski N, et al. Epidermal graft encourages wound healing by down-regulation of gap junctional protein and activation of wound bed without graft integration as opposed to split-thickness skin graft. Int Wound J. 2021; 18(3): 332-341. DOI: 10.1111/ iwj.13536. Epub 2021 Mar 9.

25. Jackson SR, Roman S. Matriderm and Split Skin Grafting for Full-Thickness Pediatric Facial Burns. J Burn Care Res. 2019; 40(2): 251-254. DOI: 10.1093/jbcr/irz006.

 

PRACTICAL EXPERIENCE

UDC 616.62-006.03:616-003.84

DOI: 10.20969/VSKM.2022.15(6).133-137

PDF download CALCIFICATION OF A PARAURETHRAL CYST (а clinical case)

MANSUR AKHMAD, ORCID ID: 0000-0001-9880-5410; assistant professor of the Department of urology and operative nephrology with course of oncourology of the Medical Institute at Peoples’ Friendship University of Russia, Russia, 117198, Moscow, Miklukho-Maklay str., 6, e-mail: Аhmed1986-ma@mail.ru

GRITSKIEVICH АLEXANDER А., ORCID ID: 0000-0002-5160-925Х; D. Med. Sci., the Head of the Department of the urology of A.V. Vishnevsky National Medical Research Center of Surgery; professor of the Department of urology and operative nephrology with course of oncourology of Medical Institute at Peoples’ Friendship University of Russia, Russia, 117198, Moscow, Miklukho-Maklay str., 6, e-mail: grekaa@mail.ru

KULCHENKO NINA G., ORCID ID: 0000-0002-4468-3670; SPIN: 1899-7871; Author ID: 543055; C. Med. Sci., urologist, associate professor of the Department of human anatomy of Medical Institute at Peoples’ Friendship University of Russia, Russia, 117198, Moscow, Miklukho-Maklay str., 6, e-mail: kle-kni@mail.ru

DEREVIANKO TATJANA I., ORCID ID: 0000-0003-1659-319X; professor, the Head of the Department of urology, pediatric urology-andrology, obstetrics and gynecology of Stavropol State Medical University, Russia, 355017, Stavropol, e-mail: uro-dep@yandex.ru

POSPELOVA OLGA M., ORCID ID: 0000-0002-5762-9171; internal medicine physician, hematologist, clinical pharmacologist of Moscow Multidisciplinary Clinical Center «Kommunarka», Russia, 142770, Moscow, e-mail: pospelova.olga@mail.ru

MYANDINA GALINA I., ORCID ID: 0000-0002-7613-326X; D. Biol. Sci., professor of the Department of biology and general genetics of the Medical Institute at Peoples’ Friendship University of Russia, Russia, 117198, Moscow, Miklukho-Maklay str., 6, e-mail: myandina_gi@pfur.ru

MIROSHKINA IRINA V., ORCID ID: 0000-0002-5341-2100; junior researcher of the Department urology of A.V. Vishnevsky National Medical Research Center of Surgery, Rossia, 117997, Moscow, e-mail: homa0308@gmail.com

Abstract. Introduction. Paraurethral cyst is a benign neoplasm of the perineal region, round, having a retention cavity with liquid contents. Being located near the urethra, paraurethral cyst can cause disturbances in the patient’s urodynamics, which are manifested both in the prolongation of urination time and in the reduction of the maximum urination rate. Prolonged persistence of paraurethral cyst can lead to morphological changes in its wall, up to malignant transformation. The recommended treatment is surgery. Aim. Analysis of the scienti c medical literature on paraurethral cyst with the presentation of personal clinical observation. Material and methods. An analysis of the medical literature devoted to the problem has been performed. We demonstrate a clinical observation of a woman with calcinosis paraurethral cyst. Resultsand discussion. In a 43-year-old patient, during the examination, we suspected calci cation of the paraurethral cyst wall, because of which during the operation there were dif culties in excising this benign neoplasm from the surrounding tissues. Clinical urinalysis and urinalysis according to Nechiporenko did not reveal any changes. According to the ultrasound of the perineum, uneven thickening of the walls of the paraurethral cyst up to 3 mm and hyperechogenicity of its wall and homogeneity of the cyst cavity were noted. According to uro owmetry: Qmax – 16,3 ml/s, the average volumetric ow rate of urine – 6,1 ml/s, urination time – 69 s. Technical dif culties during the operation did not affect the course of the postoperative period. The patient was discharged from the hospital in a satisfactory condition. Two weeks after the operation, the patient noted a subjective improvement in the quality of urination, and uro owmetry indicators improved by an average of 25%. Conclusion. Long-term paraurethral cyst not only cause urodynamic disturbances in patients, but also undergo structural changes. Preliminary diagnosis allows you to suspect changes in the paraurethral cyst wall, which should be considered when choosing a treatment tactic for a particular patient.

Key words: paraurethral cyst, calci cation, benign formation of the perineal region, urodynamic disorder.

For references: Mansur A, Gritskievich АА, Kulchenko NG, et al. Calci cation of a paraurethral cyst (а clinical case). The Bulletin of Contemporary Clinical Medicine. 2022; 15(6): 133-137. DOI: 10.20969/VSKM.2022.15(6).133-137.

References

1. Blaivas JG, Flisser AJ, Bleustein CB, Panagopoulos G. Periurethral masses: etiology and diagnosis in a large series of women. Obstet Gynecol. 2004; 103 (5 Pt 1): 842-847. DOI: 10.1097/01.AOG.0000124848.63750.e6.

2. Костин А.А., Шаплыгин Л.В., Кульченко Н.Г. [и др.]. Парауретральные кисты у женщин. Особенности диагностики // Исследования и практика в медицине. – 2020. – Т. 7, вып. 1. – С.48–54. [Kostin AA, Shaplygin LV, Kulchenko NG, et al. Parauretral’nye kisty u zhenshchin. Osobennosti diagnostiki [Paraurethral cysts in women. Features of diagnostics]. Issled. prakt. Med. [Research and Practical Medicine Journal]. 2020; 7 (1): 48-54. (In Russ.)]. DOI: 10.17709/2409-2231-2020-7-1-59.

3. Костин А.А., Шаплыгин Л.В., Кульченко Н.Г., Мансур А. Комбинированное лечение инфицированной кисты парауретральной железы // Исследования и практика в медицине. – 2021. – Т. 8, вып. 1. – С.69–74. [Kostin AA, Shaplygin LV, Kulchenkо NG, Mansur A. Kombinirovannoe lechenie inficirovannoj kisty parauretral’noj zhelezy [Combined treatment of an infected paraurethral cyst]. Issled. i prakt. V Med. [Research and Practical Medicine Journal]. 2021; 8 (1): 69-74. (In Russ.)]. DOI: 10.17709/2409-2231-2021-8-1-7.

4. Eilber KS, Raz S. Benign cystic lesions of the vagina: a literature review. J Urol. 2003; 170 (3): 717-22. DOI: 10.1097/01.ju.0000062543.99821.a2.

5. Shari aghdas F, Daneshpajooh A, Mirzaei M. Paraurethral cyst in adult women: experience with 85 cases. Urol J. 2014; 11 (5): 1896-1899. URL: https://pubmed.ncbi.nlm. nih.gov/25361711/

6. Milani R, Manodoro S, Cola A, et al. Surgical excision of paraurethral cyst. Int Braz J Urol. 2020; 46(2): 298-299. DOI: 10.1590/S1677-5538.IBJU.2018.0761.

7. Saito J, Tanaka H, Hoshina M, et al. Paraurethral cyst in a female newborn: A case report. Pediatr Int. 2020; 62 (1): 103-105. DOI: 10.1111/ped.14043.

8. Bataineh ZA, Al Quran TM, Alabdulghany MH, et al. Neonatal Para-urethral Cyst: A Report of Three Cases. J Pediatr Adolesc Gynecol. 2022; 35 (1): 85-87. DOI: 10.1016/j.jpag.2021.07.002.

9. Sto kov S, Emin A, Stambolov B. Parauretalni kistidiagnoza, diferentsialna diagnoza i lechenie (s prinos ot edin slucha ) [Paraurethral cysts-diagnosis, differential diagnosis and treatment (a case report)]. Akush Ginekol (So ia). 2004; 43(6): 57-60.

10. Shah SR, Biggs GY, Rosenblum N, Nitti VW. Surgical management of Skene’s gland abscess/infection: a contemporary series. Int Urogynecol J. 2012; 23 (2): 159-164. DOI: 10.1007/s00192-011-1488-y.