Vol. 8 Issue 2 (2015)

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ORIGINAL ARTICLES

Effects of tobacco smoking on the quality of life in oil industry workers with chronic obstructive pul-monaty disease. A.Yu. Abdullaev

Assessment the probability of burnout syndrome formation in health care workers. R.V. Garipova, Z.M. Berkheeva, S.V. Kuzmina

Ramipril and amlodipin therapy effects on endothelial vasodilatation in women with postmenopausal metabolic syndrome. A.R. Ishmanova, I.E. Nikolaeva, A.N. Zakirova, S.M. Yanbaeva

Correlation of the clinical-immunological and neuro-imaging displays of activity of relapsing remitting multiple sclerosis progress. T.A. Kobys

Pneumocystis carinii in pattients with combined coinfection (HIV/tuberculosis) according to patomorfological researches. A.M. Mikhailovskiy, S.A. Churkin

Retrospective analysis of the results of selective portosystemic shunts in patients with portal hypertension. F.G. Nazyrov, A.V. Devyatov, A.Kh. Babadzhanov, S.A. Raimov, R.R. Baybekov, E.I. Nigmatullin

Endovascular revascularization of total renal artery occlusion in patients with ischemic kidney disease. A.Z. Sharafeev, A.F. Khalirakhmanov, A.V. Postnikov, B.M. Sharafutdinov, T.R. Khabibulayev, A.V. Bagautdinov

REVIEW

Epidemiological aspects of children bronchial tubes disease. A.V. Bogdanova, Ts.V. Zandakov, O.N. Titova, E.V. Bojtsova, M.M. Goloborod'ko

Duodenogastric reflux as a cause of reflux-gastritis. Sh.Z. Galiev, N.B. Amirov

Benefits and harm of electronic cigarettes through the prism of different therapeutic methodologies. V.D. Mendelevich

ORGANIZATION OF HEALTHCARE

Clinical and statistical analysis of morbidity with temporary disability of the economically active population of Kazan city. N.N. Shamsiyarov, A.N. Galiullin

HELP FOR PRACTITIONER

Treatment of allergic rhinitis in women during pregnancy. A.A. Vasiljeva, R.F. Khakimova

CLINICAL CASE

Free wall myocardium rupture and thrombolytic therapy. Clinical observation. N.A. Kosheleva, D.V. Krasikov, I.A. Morozov, A.P. Rebrov

 

ORIGINAL ARTICLES

PDF downloadEffects of tobacco smoking on the quality of life in oil industry workers with chronic obstructive pulmonaty disease

AdalYat Yu. Abdullaev, Head of Department of pulmonology Central Oil industry workers hospital, Azerbaijan, Baku, tel. +9-945-021-054-23, e-mail: dr_adalyat@adanet.az

Abstract. Aim. To compare the results of physical examination in patients with chronic obstructive pulmonary disease (COPD) with nicotine addiction to subjective indicators based on the quality of life questionnaire SF-36. Material and methods. We examined 255 patients with chronic obstructive pulmonary disease, with varying degrees of nicotine addiction. All of them were employees of the oil industry. The complex survey included methods of objective evaluation of respiratory function, and the results of a comparative study conducted using SF-36 quality of life in this group of patients. Results. Found that smoking affects not only the objective condition of the patient, but also on subjective health indicators included in the concept of quality of life. Conclusions. Tobacco smoking negatively affects both the physical and social activity in the patients with COPD, as well as their psychological and emotional sphere.

Key words: chronic obstructive pulmonary disease, quality of life, smoking.

 

References

  1. Amirov, N.B. Tabachnaya epidemiya: farmakologicheskie vozmozhnosti bor’by [Tobacco epidemic: pharmacological possibilities of struggle] / N.B. Amirov, T.I. Andreeva // Vestnik sovremennoi klinicheskoi mediciny [Bulletin of modern clinical medicine]. — 2011. — T. IV, vyp. 3. — S.28—33.
  2. Osobennosti formirovaniya bronhoobstruktivnogo sindroma u rabotnikov MVD i MCHS, rabotayuschih v avtoinspekcii i v pozharnoi sluzhbe [Peculiarities of bronchial obstruction in the Interior Ministry and the Emergencies Ministry workers working in the traffic police and fire service] / N.B. Amirov, A.A. Vizel’, M.V. Potapova [i dr.] // Vestnik sovremennoi klinicheskoi mediciny [Bulletin of modern clinical medicine]. — 2008. — T. I, vyp. 1. — S.95—98.
  3. Antonov, N.S. Hronicheskaya obstruktivnaya bolezn’ legkih u kuryaschih: rannyaya stadiya bolezni [Chronic obstructive pulmonary disease in smokers: the early stage of the disease] / N.S. Antonov, G.M. Saharova // Terapevticheskii arhiv [Therapeutic archive]. — 2009. — № 3. — S.82—84.
  4. Global’naya strategiya diagnostiki, lecheniya i profilaktiki 4. hronicheskoi obstruktivnoi bolezni legkih (peresmotr 2008 g.) [Global strategy for the diagnosis, treatment and prevention of chronic obstructive pulmonary disease (revision 2008)] / pod red. A.S. Belevskogo; per. s angl. — M.: Atmosfera, 2009. — 100 s.
  5. Dvoreckii, L.I. Kachestvo zhizni pozhilogo bol’nogo [Quality of life of elderly patients] / L.I. Dvoreckii // Consilium Medicum. — 2009. — № 11. — S.98—102.
  6. Il’kovich, M.M. Bor’ba s tabakokureniem, kak osnova profilaktiki hronicheskoi obstruktivnoi bolezni legkih [Tobacco control, as a basis for the prevention of chronic obstructive pulmonary disease] / M.M. Il’kovich, N.A. Kuzubova, E.A. Kisileva // Pul’monologiya [Pulmonology]. — 2010. — № 2. — S.37—39.
  7. Novik, A.A. Rukovodstvo po issledovaniyu kachestva zhizni v medicine [Guidelines for Quality of Life Research in Medicine]/ A.A. Novik, T.I. Ionova. — M., 2007. — 156 s.
  8. Rebrova, O.Yu. Statisticheskii analiz medicinskih dannyh. Primenenie paketa prikladnyh programm Statistica [Statistical analysis of medical data. Application software package Statistica] / O.Yu. Rebrova. — M., 2000. — 122 s.
  9. Sincova, S.V. Tabakokurenie — epidemiya HHI veka [Smoking — an epidemic of the XXI century] / S.V. Sincova, E.N. Chicherina // Tuberkulez i bolezni legkih [Tuberculosis and Lung Disease]. — 2011. — № 3. — S.23—26.
  10. Stasyuk, O.N. Ocenka kachestva zhizni u bol’nyh hronicheskoi obstruktivnoi bolezn’yu legkih [Quality of life in patients with chronic obstructive pulmonary disease] / O.N. Stasyuk, M.I. Ul’yanova // Nauchno-medicinskii vestnik Central’nogo CHernozem’ya [Scientific and Medical Bulletin of the Central Black Earth region]. — 2008. — № 32. — S.29—32.
  11. Chernyak, B.A. Kachestvo zhizni u bol’nyh hronicheskoi obstruktivnoi bolezni legkih [Quality of life in patients with chronic obstructive pulmonary disease] / B.A. Chernyak // Hronicheskaya obstruktivnaya bolezn’ legkih [Chronic obstructive pulmonary disease] / pod red. A.G. Chuchalina. — M.: Atmosfera, 2008. — S.322—338.
  12. Shmelev, E.I. Izmenenie parametrov spirometrii forsirovannogo vydoha u bol’nyh HOBL (rezul’taty dlitel’nogo nablyudeniya) [Change the settings for forced expiratory spirometry in patients with COPD (long-term monitoring results)] / E.I. Shmelev, I.Yu. Vizel’, A.A. Vizel’ // Tuberkulez i bolezni legkih [Tuberculosis and Lung Disease]. — 2010. — № 8. — S.50—56.
  13. Comparison of demographic data of patients with COPD treated in primary care by country in European Health-related Quality of Life in COPD study / P.W. Jones, G. Brusselle, T. van der Molen [et al.] // Eur. Resp. J. — 2010. — Vol.36, suppl. 54. — P. 4233.
  14. Primary care physician assessment of COPD severity: European Health-related Quality of Life in COPD study / P. Kardos, P.W. Jones, M.L. Levy [et al.] // Eur. Resp. J. — 2010. — Vol. 36, suppl. 54. — P.4228.

 

PDF downloadAssessment the probability of burnout syndrome formation in health care workers

Railya V. Garipova, C.Med.Sci., assistant of professor of Department of hygiene and occupational health of SBEI HPE «Kazan State Medical University» of Russian Ministry of Health, Kazan, Russia, tel. 8-917-255-38-44, е-mail: railyagaripova@mail.ru

Zukhra M. Berkheeva, C.Med.Sci., associate professor of Department of hygiene and occupational health of SBEI HPE «Kazan State Medical University» of Russian Ministry of Health, Kazan, Russia, tel. 8-905-310-74-46, е-mail: kgmu_profpat@mail.ru

Svetlana V. Kuzmina, C.Med.Sci., assistant of professor of Department of hygiene and occupational health of SBEI HPE «Kazan State Medical University» of Russian Ministry of Health, Kazan, Russia, tel. 8-987-296-22-49, е-mail: skouzmina21@list.ru

Abstract. Aim. To study the psychosocial risk factors in the of burnout syndrome formation. Material and methods. Based on a questionnaire developed by WHO experts for the European model of «health management, environment and security in the workplace», we conducted survey of 246 health care workers. The questionnaire presents questions that reflect social status, lifestyle, character and safety of employment, the presence of stress factors both production and non-production nature. Special attention was paid to health, physical activity and nutrition. Results. Survey conducted of the medical personnel showed high prevalence of psychophysical, social and psychological, behavioral symptoms among them that allows to think about the high probability of formation of a syndrome of professional burning out.

Key words: health care workers, occupational stress, burnout syndrome.

 

References

  1. Psihosocial’nye faktory truda, obraz zhizni i zdorov’e vrachei v sovremennyh usloviyah: posobie dlya vrachei [Psychosocial factors of work, lifestyle and health of doctors in modern conditions: а guide for doctors] / V.T. Kaibyshev, A.R. Galimov, N.I. Simonova [i dr.]. — M., 2007. — S.48.
  2. Garipova, R.V. Rol’ psihosocial’nyh faktorov v razvitii sindroma professional’nogo vygoraniya [The role of psychosocial factors in the development of burnout syndrome] / R.V. Garipova, I.R. Galieva // Svyaz’ zabolevaniya s professiei s pozicii dokazatel’noi mediciny: materialy Vseros. nauch.-prakt. konf. s mezhdunarodnym uchastiem [Communication of a disease with a profession from a position of evidential medicine: materials of All-Russian scientific and practical conference with the International participation]. — Kazan’, 2011. — S.243—245.
  3. Garipova, R.V. Osobennosti formirovaniya sindroma professional’nogo vygoraniya u predstavitelei medicinskih special’nostei, rabotayuschih v gorodskoi i sel’skoi mestnosti [Features of formation of professional burnout syndrome in the health care professions working in urban and rural areas] / R.V. Garipova, I.R. Galieva // Zdorov’e cheloveka v XXI veke: sb. nauch. st. IV Ros. nauch.-prakt. konf. [Human health in the XXI century: collection of scientific articles Russian scientific and practical conference]. — Kazan’, 2012. — S.513—517.
  4. Stress and Psychological Disorders in Great Britain 2013 [electronic resource]. — URL: http: //www.hse.gov.uk/statistics/causdis/stress/stress.pdf
  5. Tsai, Y.-C. Factors and symptoms associated with work stress and healthpromoting lifestyles among hospital staff: a pilot study in Taiwan / Y.-C. Tsai, С.-Н. Liu // BMC Health Serv. Res. — 2012. — Vol. 12. — Р.199.
  6. Tyssen, R. Health рroblems and the use of health services among physicians: a review article with particular emphasis on Norwegian studies / R. Tyssen // Industrial Health. — 2007. — Vol. 45. — Р.599—610.
  7. Work-related stress in nursing. — Geneva: ILO, 2000. — 52 p.

 

PDF downloadRamipril and amlodipin therapy effects on endothelial vasodilatation in women with postmenopausal metabolic syndrome

Aigul R. Ishmanova, C.Med.Sci., cardiologist of Republican Cardiology Center, Ufa, Russia, tel. 8-987-109-46-67, e-mail: ishmanova.2012@mail.ru

Irina E. NiKolaeva, C.Med.Sci., Chief of Republican Cardiology Center, Ufa, Russia, tel. 8-917-752-35-46

Alara N. Zakirova, D.Med.Sci., Heard of Department of сlinical сardiology of SBEI HPE «Bashkir State Medical University» Russian Ministry of Health, Ufa, Russia, tel. 8-917-345-99-23

Sakina M. Yanbaeva, C.Med.Sci., cardiologist of Republican Cardiology Center, Ufa, Russia, tel. 8-917-485-16-19

Abstract. Aim. To compare the effects of ramipril and amlodipin on the vasodilatation function of endothelium in arterial hypertension (AH) treatment in women with postmenopausal metabolic syndrome (MS). Material and methods. Study included 80 postmenopausal women with AH and MS. Control group consisted of 25 women without apparent disease. Duration of treatment was 24 weeks. Antihypertensive effect of these drug combinations and their effects on the endothelium-dependent vasodilatation were evaluated. Endothelial function was analyzed by the reactive hyperemia test using high-resolution ultrasound; nitric oxide metabolites were measured in blood serum by the method of Emchenco et. al. (1994). Results. It was shown that ramipril in combination with amlodipine more effectively controlled blood pressure in postmenopausal patients with AH and MS. This combination therapy had a more pronounced endothelium-protective effect characterized by recovering of endothelium-dependent vasodilatation (EDV) and increased production of nitric oxide metabolites. Conclusion. Therefore ramipril in combination with amlodipine can be recommended for the treatment of postmenopausal women with AH and MS.

Key words: arterial hypertension, metabolic syndrome, postmenopausal, endothelial dysfunction, ramipril, amlodipin.

 

References

  1. Bahshaliev, A.B. Sravnitel'naya effektivnost' moksonidina i prestariuma u zhenschin v postmenopauzal'nom periode s myagkoi i umerennoi arterial'noi gipertoniei [Comparative efficacy of moxonidine and prestarium in postmenopausal women with mild to moderate hypertension] / A.B. Bahshaliev, G.M. Sabzalieva // Obzory klinicheskoi kardiologii [Reviews Clinical Cardiology]. — 2007. — № 11. — C.35—39.
  2. Belenkov, Yu.N. Rezul'taty mnogocentrovogo randomizirovannogo otkrytogo issledovaniya po izucheniyu effektivnosti izmeneniya obraza zhizni i terapii ingibitorami APF u bol'nyh AG i MS [Results of a multicenter, randomized, open-label study to evaluate the efficacy of lifestyle changes and treatment with ACE inhibitors in patients with hypertension and MS] / Yu.N. Belenkov, I.E. Chazova, V.B. Mychka // Kardiologiya [Cardiology]. — 2004. — № 4. — C.14—17.
  3. Zadiochenko, V.S. Psihologicheskie osobennosti i kachestvo zhizni bol'nyh arterial'noi gipertenziei i metabolicheskimi faktorami riska [Psychological characteristics and quality of life in patients with hypertension and metabolic risk factors] / V.S. Zadiochenko, S.B. Hrulenko, T.V. Adasheva // Kardiologiya [Cardiology]. — 2000. — № 10. — C.38—41.
  4. Zateischikova, A.A. Endotelial'naya regulyaciya sosudistogo tonusa: metody issledovaniya i klinicheskoe znachenie [Endothelial regulation of vascular tone: research methods and clinical significance] / A.A. Zateischikova, D.A. Zateischikov // Kardiologiya [Cardiology]. — 1998. — № 9. — C.68—80.
  5. Kobalava, Zh.D. Klinicheskie osobennosti i lechenie arterial'noi gipertonii u zhenschin [Clinical features and treatment of hypertension in women] / Zh.D. Kobalava, V.V. Tolkacheva, O.N. Moryleva // Serdce [Heart]. — 2004. — № 6. — C.284—288.
  6. Kovaleva, I.B. Funkciya endoteliya u zhenschin s arterial'noi gipertenziei v postmenopauze [Endothelial function in women with hypertension in postmenopausal] / I.B. Kovaleva, S.E. Myasoedova, I.K. Bogatova // Kardivaskulyarnaya terapiya i profilaktika [Kardiovaskular therapy and prevention]. — 2004. — № 3. — C.4—8.
  7. Leonova, M.V. Sravnitel'naya effektivnost' i bezopasnost' sovremennyh ingibitorov angiotenzinprevraschayuschego fermenta moeksiprila i spiraprila u zhenschin s postmenopauzal'nym metabolicheskim sindromom [Comparative efficacy and safety of modern angiotensin converting enzyme inhibitor moexipril and spirapril in women with postmenopausal metabolic syndrome] / M.V. Leonova, M.A. Demidova, A.V. Tarasov // Kardiologiya [Cardiology]. — 2006. — № 5. — C.40—43.
  8. Mamedov, M.N. Vybor gipotenzivnoi terapii pri metabolicheskom sindrome: deistvie enalaprila na lipidnyi i uglevodnyi obmen [The choice of antihypertensive therapy in metabolic syndrome: effect of enalapril on lipid and carbohydrate metabolism] / M.N. Mamedov, O.V. Kosmatova, I.V. CHudakova // Serdce [Heart]. — 2004. — № 3. — C.129—133.
  9. Nibieridze, D.V. Metabolicheskie i sosudistye effekty antigipertenzivnoi terapii [Metabolic and vascular effects of antihypertensive therapy] / D.V. Nibieridze, R.G. Oganov. — M.: Universum Pablishing, 2005. — C.66—104.
  10. Ol'binskaya, L.I. Arterial'naya gipertoniya u zhenschin v prostmenopauze i ee lechenie enalaprilom [Hypertension in women prostmenopauze and its treatment with enalapril] / L.I. Ol'binskaya, B.A. Hapaev, S.A. Sayumakova // Konsilium medikum [Consilium Medicum]. — 2006. — № 5. — C.38—41.
  11. Ostroumova, O.D. Starenie i disfunkciya endoteliya [Aging and endothelial dysfunction] / O.D. Ostroumova, R.E. Dubinskaya // Kardiologiya [Cardiology]. — 2005. — № 2. — C.59—62.
  12. Ostroumova, O.D. Disfunkciya endoteliya pri CCZ [Endothelial dysfunction with CVD] / O.D. Ostroumova, R.E. Dubinskaya // Kardiovaskulyarnaya terapiya i profilaktika [Cardiovascular therapy and prevention]. — 2004. — № 3. — C.83—85.
  13. Smetnik, V.P. Menopauza i serdechno-sosudistaya sistema [Menopause and cardiovascular system] / V.P. Smetnik, I.G. Shestakova // Terapevticheskii arhiv [Therapeutic archive]. — 1999. — № 10. — C.61—65.

 

PDF downloadCorrelation of the clinical-immunological and neuroimaging displays of activity of relapsing remitting multiple sclerosis progress

Tatiana A. Kobys, C.Med.Sci., candidate of a degree of Department of neurology of National Medical University n.a. o. Bogomolets, Kiev, ukraine, tel. +38 067 287-31-65, e-mail: tkobys@ukr.net

Abstract. Аim. The purpose to the study was to determine the correlation and prognostic values of clinical, immunological and neuroimaging signs of activity of relapsing-remitting multiple sclerosis (RRMS). Material and methods. We examined 72 patients with RRRS. We registered the nature of disease onset, relapse rate, and EDSS level. Neuroimaging was done using GE Signa Excite HD 1,5T scanner. We determined the number of T2- and T1-lesions and further conducted H1-MR spectroscopy in different areas. Synthesis and secretion of cytokines IL-1, IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ were studied in the culture of human mononuclear cells. Statistica 10.0 software was used for data processing. Results. The work presents the findings of the 9-year follow-up of RRMS patients. Signs of the CIS (mono- and polysymptomatic) had average correlation with the level of EDSS and weak correlation with relapse frequency in RRMS patients. Average correlation was found between the number of T1 and T2 lesions > 3 mm and EDSS level. Changes in the level of cerebral metabolites (NAA, Cho) were identified both in demyelination lesions and intact brain tissue. Prognostic value of the timing of the relapse development using the Kaplan — Meier was influenced by such factors as the size of lesions, number of T2 lesions on early stages of the disease and reduced NAA/Cr, Cho/Cr indices. Increased lactate levels in demyelinating lesions had a strong correlation with relapse frequency. We determined persistent elevation of proinflammatory cytokines in patients with active course of the disease and a strong positive correlation with the number of relapses per year. Conclusion. In assessing RRMS activity one should take into account clinical and neuroimaging methods of monitoring, which have varying degrees of relationship and prognostic significance.

Key words: relapsing-remitting multiple sclerosis, disease activity, disability progression, lesions, cerebral metabolytes, cytokines.

 

References

  1. Voloshina, N.P. Vozmozhnosti magnitno-rezonansnoi tomografii v diagnostike i prognoze techeniya rasseyannogo skleroza v zavisimosti ot pola i vozrasta bol’nyh [The possibility of magnetic resonance imaging in the diagnosis and prognosis of multiple sclerosis according to the sex and age of the patients] / N.P. Voloshina, I.K. Gaponov // Ukraїns’kii vіsnik psihonevrologії. — 2010. — T. 2, № 3(64). — S.19—23.
  2. Flomin, Yu.V. Ispol’zovanie MRT pri rasseyannom skleroze [The use of MRI in multiple sclerosis] / Yu.V. Flomin, A.E. Kostyukovskaya, V.N. Kucyn // Neiron-revyu [Neuron-revue]. — 2008. — № 6. — S.1—12.
  3. Shmidt, T.E. Rasseyannyi skleroz [Multiple Sclerosis] / T.E. Shmidt, N.N. Yahno. — M., 2012. — 271 s.
  4. Cadavid, D. Clinical cosequences of MRI activity in treatyd multiple sclerosis / D. Cadavid, S. Kim, B. Peng // MS Journal. — 2011. — Vol. 17, № 1. — P.32—42.
  5. Compston, A. Multiple sclerosis / A. Compston, A. Coles // Lancet. — 2008. — № 372. — P.1502—1517.
  6. Dobson, R. An under-studied source of biomarkers in Multiple Sclerosis / R. Dobson // MS and related disorders. — 2012. — Vol. 1. — P.76—80.
  7. EFNS guidlines on the use of neuroimaging in the management of multiple sclerosis / M. Fillipi, M.A. Rocca, D.L. Arnold [et al.] // Eur. J. Neurol. — 2006. — № 16. — Р.448—456.
  8. Fisniku, L. Disability and T2 MRI lesins: a 20-year follow-up of patient with relapse onset of multiple sclerosis / L. Fisniku, M.A. Rocca, J. Comi // Brain. — 2008. — № 131. — Р.808—817.
  9. Inglese, M. Magnetic Resonance Imaging Monitoring of Multiple Sclerosis Lesion Evolution / M. Inglese, R.I. Grossman, M. Filippi // J. of Neuroimaging. — 2006. — Vol. 15(sup. l4). — P.22—29.
  10. Miller, A. Translation toards personalized medicine in Multiple Sclerosis / A. Miller, N. Aidan, N. Tzunz-Henig // J. of the Neurolog. Sciences. — 2012. — Vol. 274. — P.68—75.
  11. Reproducibility over a 1-month period of 1H-MR spectroscopic imaging NAA/Cr ratios in clinically stabиle multiple sclerosis patients / J.P. Mostert, Y. Blauw, M.W. Koch [et al.] // Eur. Radiol. — 2008. — Vol. 18(8). — P.1736—1740.
  12. Narayana, P.A. Magnetic Resonance Spectroscopy in the Monitoring of Multiple Sclerosis / P.A. Narayana // J. Neuroimaging. — 2005. — Vol. 15(supp. l4). — P.46—57.
  13. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria / C.H. Рolman, S.C. Reingold, B. Banwell [et al.] // Ann. Neurol. — 2011. — Vol. 69. — P.292—302.
  14. Ramagopalan, S.P. Multiple sclerosis: risk factors, prodro- mes and potential causal pathways / S.P. Ramagopalan, R. Dobson, U.C. Meier // Lancet Neurol. — 2010. — Vol. 9. — P.727—739.
  15. H-MR spectroscopy of the brain in multiple sclerosis subtypes with analysis of the metabolite concentrations in gray and white matter: initial findings / P.E. Sijens, J.P. Mostert, M. Oudkerk [et al.] // Eur. Radiol. — 2006. — Vol. 16(2). — P.489—495.
  16. Interferon-γ induces microglial-activation-induced cell death: A hypothetical mechanism of relapse and remission in multiple sclerosis / H. Takeuchi J. Wang, J. Kawanokuchi [et al.] // Neurobiology Disease. — 2006. — Vol. 22. — Р.33—39.
  17. Baseline MRI predicts future attacks and disability in clinically isolated syndromes / M. Tintoré, A. Rovira, J. Río [et al.] // Neurology. — 2006. — Vol. 67(6). — P.968—972
  18. Ziemsenn, T. A new era in multiple sclerosis: new consideration for therapeutic approaches / T. Ziemsenn, M. Tintore // Elsevier. — 2010. — 94 p.

 

PDF downloadPneumocystis carinii in pattients with combined coinfection (HIV/tuberculosis) according to patomorfological researches

Alexey M. MiKhailovskiy, C.Med.Sci., Head of Department of pathology of SAIH «Orenburg Regional TB Clinic», assistant of Department of phthisiology and pulmonology, Orenburg, Russia, tel. 8-922-627-75-22, e-mail: michailovsky2007@yandex.ru

Sergey A. Churkin, C.Med.Sci., Head of SAIH «Orenburg Regional TB Clinic», Orenburg, Russia, e-mail: oobo5@mail.ru

Abstract. Aim. The analysis of pathomorfological picture of combined infection: pneumonia induced by Pneumocystis carinii and progressing tuberculosis in patients with late stages of a HIV-infection. Material and methods. Pathomorfological research of 6 patients with multiple forms of tuberculosis inflammation, HIV-infection and Pneumocystis carinii pneumonia was conducted. The group of the investigated patients contained of 4 men and 2 women in an age interval from 20 to 37 years, with late stages of a HIV-infection and with level CD4 T-lymphocytes < 200 cells/µl. Results. Co infection of tuberculosis and HIV-infection does not exclude presence of other infectious diseases which sometimes play an important role in death. Conclusion. Patients at late stages of a HIV-infection can often have combined infectious diseases. It is revealed that patients at late stages of a HIV-infection may have combination of multiple infectious diseases which sometimes play an important role in death. It specifies a necessity of carrying out of additional methods of research to reveal all infection pathology in patient (morphological, bacteriological and genetic methods).

Key words: pneumocystosis, tuberculosis, HIV-infection, combined confection HIV—tuberculosis.

 

References

  1. Pnevmocistnaya pnevmoniya v sochetanii s tuberkulezom kak pervye klinicheskie proyavleniya na pozdnih stadiyah VICH-infekcii [P.C. pneumonia in a combination with tuberculosis as the first clinical displays at late stages of a HIV-infection] / T.N. Ermak, N.G. Litvinova, E.R. Samitova [i dr.] // Terapevticheskii arhiv [Therapeutic Archives]. — 2005. — № 11. — S.21—23.
  2. Pnevmocistnaya pnevmoniya, tuberkulez legkih i ih sochetanie u bol'nyh VICH-infekciei [P.C. pneumonia, tuberculosis of lungs and their combination at sick of a HIV-infection] / T.N. Ermak, N.G. Litvinova, E.R. Samitova [i dr.[ // Epidemiologiya i infekcionnye bolezni. — 2008. — № 3. — S.31—34.
  3. Kletochnaya biologiya legkih v norme i patologii: rukovodstvo dlya vrachei [Cellular biology of lungs in norm and a pathology] / pod red. V.V. Erohina, L.K. Romanovoi. — M.: Medicina, 2000. — 496 s.: il.
  4. Lepeha, L.N. Pnevmocistoz legkogo v eksperimente i klinike [Lung pneumocystosis in experiment and clinic] / L.N. Lepeha, T.G. Barhina, Yu.G. Parhomenko // Arhiv patologii. — 1998. — № 5. — S.46—52.
  5. Mihailovskii, A.M. Patomorfologiya tuberkuleza na pozdnih stadiyah VICH-infekcii (po dannym autopsii) [Pathology of Tuberculosis in the later stages of HIV infection (according to autopsy)] / A.M. Mihailovskii // Tuberkulez s lekarstvennoi ustoichivost'yu k MBT u bol'nyh VICH-infekciei: materialy III Vseros. nauch.-prakt. konf. — Tver': OOO «Izdatel'stvo «Triada», 2009. — S.68—69.
  6. Mihailovskii, A.M. Osobennosti kliniko-morfologicheskih proyavlenii tuberkuleza, sochetannogo s VICH-infekciei v Orenburgskoi oblasti [Features of kliniko-morphological displays of a tuberculosis, combined with a HIV-infection in the Orenburg region]: avtoref. dis. ... kand. med. nauk / Mihailovskii Aleksei Modestvovich. — M., 2011. — 27 s.
  7. Samitova, E.R. Sluchai sochetaniya pnevmocistnoi pnevmonii s disseminirovannym tuberkulezom legkih u bol'nogo VICH-infekciei [Combination case of P.C. pneumonia with a lung tuberculosis at sick of a HIV-infection] / E.R. Samitova, A.K. Tokmalaev, T.N. Ermak // Vestnik RUDN. — 2006. — № 1. — S.81—83.
  8. Current Epidemiology of Pneumonia / A. Morris, J.D. Lundren, H. Masur [et al.] // Emerg. Infect. Dis. — 2004. — Vol. 10(10). — P.1713—1720.

 

PDF downloadRetrospective analysis of the results of selective portosystemic shunts in patients with portal hypertension

Feruz G. Nazyrov, D.Med.Sci., Professor, Director of the Acad. V.Vakhidov republican Specialized center of Surgery, Tashkent, Uzbekistan, tel. 8-371-233-49-09, e-mail: cs75@mail.ru

Andrey V. Devyatov, D.Med.Sci., Professor, chief researcher at the Department of surgery of portal hypertension and pancreatoduodenal zone of the Acad. V.Vakhidov republican Specialized center of Surgery, tashkent, uzbekistan, tel. 8-371-277-06-17, e-mail: avdevyatov1777@gmail.com

Azam Kh. Babadzhanov, C.Med.Sci., senior research fellow at the Department of surgery of portal hypertension and pancreatoduodenal zone of the Acad. V.Vakhidov republican Specialized center of Surgery, tashkent, uzbekistan, tel. 8-371-277-06-17, e-mail: azam747@mail.ru

Salokhiddin A. Raimov, trainee researcher, applicant at the Department of surgery of portal hypertension and pancreatoduodenal zone of the Acad. V.Vakhidov republican Specialized center of Surgery, tashkent, uzbekistan, tel. 8-371-277-06-17, e-mail: cs75@mail.ru

Renat R. Baybekov, junior researcher at the Department of surgery of portal hypertension and pancreatoduodenal zone of the Acad. V.Vakhidov republican Specialized center of Surgery, tashkent, uzbekistan, tel. 8-371-277-06-17, e-mail: renat.baybekov@gmail.com

Elnar I. Nigmatullin, master of the second year of the Tashkent Medical Academy, Tashkent, Uzbekistan, tel. 8-371-277-06-17, e-mail: etoyaek@mail.ru

Abstract. Aim — to analyze the results of selective portosystemic shunt in patients with portal hypertension. Material and methods. Analysis is carried out in three study groups: the first group — the implementation phase, which covered the period from 1976 to 1992; the second group — a step of forming a specialized unit of surgery of PH in RSCS (1992—1998); the third group — stage of improvement techniques of DSRS and expanding indications for this type of bypass (1998—2014). The study included 396 patients with PH, whom were performed DSRS, for the periods indicated. Results and discussion. The incidence of hepatic failure and encephalopathy in the implementation phase of PSSH reached 25% and 33,3%, respectively, in the future, after standardization indications for DSRS its frequency decreased to 14,3% and 17,1%, while in the present period developed in 5,1% of cases and the clinical signs of encephalopathy in 10,9% of patients. The frequency of bleeding against the backdrop of a functioning DSRS established in 16 out of 23 of our patients with bleeding from esophageal varices. The growth of ascites averaged a total group of patients with DSRS — in 11,3% of cases. Depending on the chronological period, the frequency of this complication has decreased from 20,8% in the first period to 10,1% in the third period. Selective shunt thrombosis in the immediate postoperative period was 1,8%, bleeding from esophageal varices — 4,7% of cases. Conclusion. Depending on the characteristics of the vascular transformation of splenic vein DSRS in the present period is dominant and performed in more than 50% of cases, and for the older age group or a low compensatory allowance hepatocytes against a background of cirrhosis of the liver, this type of bypass surgery remains a priority, and sometimes and the only way to decompress of portal pool.

Key words: liver cirrhosis, portal hypertension, portosystemic shunts, the distal splenorenal shunt, bleeding from esophageal varices.

 

References

  1. Nazyrov, F.G. Otdalennye rezul'taty distal'nogo splenorenal'nogo anastomoza u bol'nyh cirrozom pecheni [Long-term results of distal splenorenal anastomosis in patients with cirrhosis] / F.G. Nazyrov, A.V. Devyatov, R.A. Ibadov // Annaly hirurgicheskoi gepatologii [Annals of Surgical Hepatology]. — 2007. — № 4. — S.36—41.
  2. Turakulov, A.B. Hirurgicheskie aspekty sindroma splenomegalii u bol'nyh cirrozom pecheni [Surgical aspects of the syndrome of splenomegaly in patients with cirrhosis]: dis. ... kand. med. nauk / A.B. Turakulov. — Tashkent, 2006. — 126 s.
  3. Regulyaciya cirkulyacii krovi pri hirurgicheskoi korrekcii portal'noi gipertenzii [Regulation of blood circulation in the surgical correction of portal hypertension] / Yu.N. Shanin, B.N. Kotiv, V.N. Cygan, V.I. Ioncev // Voennyi medicinskii zhurnal [Military Medical Journal]. — 2011. — № 332(3). — S.29—34.
  4. Warren—Zeppa distal splenorenal shunts: a 34-year experience / A.S. Livingstone, L.G. Koniaris, E.A. Perez [et al.] // Ann. Surg. — 2006. — Vol. 243(6). — P.884—892.
  5. Orloff, M.J. Fifty-three years' experience with randomized clinical trials of emergency portacaval shunt for bleeding esophageal varices in Cirrhosis: 1958—2011 / M.J. Orloff // JAMA Surg. — 2014. — Vol. 149(2). — P.155—69.
  6. Rare, spontaneous trans–splenic shunt and intra–splenic collaterals with attendant splenic artery aneurysms in an adult patient with compensated cirrhosis and portal hypertension / C.A. Philips, L. Anand, K.N. Kumar [et al.] // Gastroenterol Rep. (Oxf). — 2014. — Vol. 9. — pii: gou047.
  7. A 10 year experience of shunt surgery for esophagogastric varices in a single center in Japan / Y. Sato, H. Oya, S. Yamamoto [et al.] // Hepatogastroenterology. — 2011. — Vol. 58(106). — P.444—452.
  8. Sharma, N. Portal hypertension: A critical appraisal of shunt procedures with emphasis on distal splenorenal shunt in children / N. Sharma, M. Bajpai, A. Kumar [et al.] // J. Indian. Assoc. Pediatr Surg. — 2014. — Vol. 19(2). — P.80—84.
  9. Congenital hepatic fibrosis with extra-hepatic porto-systemic shunt and hepatopulmonary syndrome successfully managed with living related liver transplantation / S. Taneja, Manavwadhawan, S. Gupta [et al.] // Trop. Gastroenterol. — 2014. — Vol. 35(2). — P.116—118.
  10. Rationale for the potential use of mesenchymal stromal cells in liver transplantation / M. Vandermeulen, C. Grégoire, A. Briquet [et al.] // World J. Gastroenterol. — 2014. — Vol. 28, № 20(44). — P.16418—16432.
  11. Nonalcoholic Steatohepatitis is the Second Leading Etiology of Liver Disease Among Adults Awaiting Liver Transplantation in the U.S. / R.J. Wong, M. Aguilar, R. Cheung [et al.] // Gastroenterology. — 2014. — Vol. S0016—5085(14). — P.1474—1477.
  12. Effects of portaazygous disconnection, portocaval shunt and selective shunts on experimental ratliver cirrhosis / X.B. Xu, J.X. Cai, J.H. Dong [et al.] // Zhonghua Gan. Zang. Bing Za Zhi. — 2005. — Vol. 13(2). — P.113—116.

 

PDF downloadEndovascular revascularization of total renal artery occlusion in patients with ischemic kidney disease

Aydar Z. Sharafeev, D.Med.Sci., Head of Department of cardiology, endovascular and cardiovascular surgery of SBEI APE «Kazan State Medical Academy» of Russian Ministry of Health, Head of Department of angiografical and x-ray surgical studies of SAIH RCH № 2, e-mail: aidarch@mail.ru

Ayrat F. Khalirakhmanov, doctor of Department of angiografical and x-ray surgical studies of SAIH RCH № 2, tel. 8-929-722-33-34, e-mail: ai.bolit@mail.ru

Alexander V. Postnikov, doctor of Department of angiografical and x-ray surgical studies of SAIH RCH, tel. 8-960-048-11-98, e-mail: sasha-postnikov@mail.ru

Bulat M. Sharafutdinov, doctor of Department of angiografical and x-ray surgical studies of SAIH RCH № 2, tel. 8-927-404-24-99, e-mail: bulaty555@mail.ru

Timur R. Khabibulayev, doctor of Department of angiografical and x-ray surgical studies of SAIH RCH, tel. 89172553048, e-mail: tim3048@mail.ru

Aydar V. Bagautdinov, doctor of Department of MRT of SAIH RCH № 2, tel. 8-937-611-19-29, e-mail: mammolog1985@mail.ru

Abstract. Aim. To analyze the effect of endovascular revascularization of total occluded renal arteries in patients with IKD in immediate and postpone periods. Material and methods. It was a comprehensive examination of the 15 patients with total occlusions of RAs, which included a study of renal function according to GFR and nephroscintigraphy, daily monitoring of BP, ultrasound imaging of the RA. According to the results, 13 patients underwent recanalization with angioplasty and stenting of chronic occlusions of the RA. For two patients recanalization was not performed. Renal function (GFR), dynamics of blood pressure, the patency of the stents has been controlled at the 7-th day, 1 month, 6 and 12 months. Results. In this study we received immediate and long-term significant improvement in renal function and reducing class of hypertension in most patients. Only one patient was identified with hemodynamic significant restenosis, required balloon dilation. Conclusion. Endovascular revascularization of total renal artery occlusion is an effective and safe procedure in patient with preserved occluded kidney function. Given that, the restoration of blood flow in stenosis of the renal arteries is an independent predictor of improvement distant prediction of survival in patients with renovascular hypertension and impaired renal function, probably revascularization of the renal arteries will lead to improve survival in these patients. This aspect must be the subject of future research.

Key words: total occlusion of the renal artery, renal artery stenting.

 

References

  1. Karev, A.V. Dvuhetapnaya chreskozhnaya angioplastika v lechenii hronicheskih okklyuzii pochechnyh arterii [Two-stage percutaneous angioplasty in the treatment of chronic occlusions of the renal arteries] / A.V. Karev, G.B. Saraev, D.V. Semenov // Mezhdunarodnyi zhurnal intervencionnoi kardioangiologii [International Journal of interventional cardiology]. — 2010. — № 7. — S.23—26.
  2. Ishemicheskaya bolezn' pochek [Ischemic kidney disease] / N.A. Muhin [i dr.] // Consilium Medicum. — 2002. — T. 4, № 7. — S.334—337.
  3. Sharafeev, A.Z. Sovremennoe sostoyanie voprosa stentirovaniya pochechnyh arterii[The present state of renal artery stenting] / A.Z. Sharafeev, A.F. Halirahmanov, B.M. Sharafutdinov // Prakticheskaya medicina [The practice of medicine]. — 2014. — № 20. — S.24—32.
  4. Sluchai uspeshnogo lecheniya ateroskleroticheskoi bilateral'noi okklyuzii pochechnyh arterii [Successful Treatment of bilateral atherosclerotic renal artery occlusion] / H.A. Yaickii, A.M. Ignashov, A.V. Smirnov [i dr.] // Nefrologiya [Nephrology]. — 2005. — T. 9, № 2. — S.117—120.
  5. Alhadad, A. Percutaneous transluminal renal angioplasty and surgical revascularization in renovascular disease a retrospective comparison of results, complications and mortality / A. Alhadad, M. Ahle, K. Ivancev // Eur. J. Endovasc. Surg. — 2004. — № 27. — P.151—156.
  6. Gross, C. Ostial renal artery placement for atherosclerotic renal artery stenosis in patients with coronary artery disease / C. Gross, J. Kramer, J. Waigand // Cath. Cardiovasc. Diagn. — 1998. — № 45. — P.1—8.
  7. Lawrie, G. Long-term results of treatment of the totally occluded renal artery in forty patients with renovascular hypertension / G. Lawrie, G. Morris, M. DeBakey // Surgery. — 1980. — № 88. — P.753—759.
  8. Oskin, T. Chronic renal artery occlusion: Nephrectomy versus revascularization / T. Oskin, K. Hansen, J. Deitch // Vasc. Surg. — 1999. — № 29. — P.22—24.
  9. Sniderman, K. Percutaneous transluminal recanalization and dilatation of totally occluded renal arteries / K. Sniderman, T. Sos // Radiology. — 1982. — № 142. — P.603—610.
  10. Rastan, A. Improved renal function and blood pressure control following renal artery angioplasty: the renal artery angioplasty in patients with renal insufficiency and hypertension using a dedicated renal stent device study (PRECISION) / A. Rastan // Eurolntervention. — 2008. — Vol. 4, № 2. — P.208—213.

 

REVIEW

PDF downloadEpidemiological aspects of children bronchial tubes disease

Alevtina V. Bogdanova, D.Med.Sci., professor, leading researcher of COPD laboratory of Pulmonology Research Institute of Pavlov first Saint Petersburg State Medical university, tel. +7-911-298-93-82, email: AlevBogdanova@yandex.ru

Tsyrendorzhi V. Zandakov, graduate student of Pulmonology Research Institute of Pavlov First Saint Petersburg State Medical University, pediatrician at Federal State Budget Health Institution Central Health Care Department 38 of Russian Federal Medical and Biology Agency, tel. +7-952-249-82-58, email: docent_do@mail.ru

Olga N. Titova, D.Med.Sci., Director of Pulmonology Research Institute of Pavlov First Saint Petersburg State Medical University

Evgenija V. Bojtsova, D.Med.Sci., Head of the Pediatric Pulmonology Laboratory

Maria M. Goloborod'ko, С.Med.Sci., pulmonologist

Abstract. Aim. To review data on chronic diseases of bronchial tubes in children (asthma, bronchopulmonary dysplasia, obliterating bronchiolitis), its prevalence and quality of diagnosis. Material and methods. We reviewed recent publications on prevalence of chronic diseases of bronchial tubes in children. A comparison of the true prevalence of chronic diseases of bronchial tubes in children with official statistics was performed. The analysis of modern classification of bronchopulmonary diseases in children (2009) applying in practical medicine. Results and discussion. Our data suggest that these diseases are one of the most severe respiratory pathology and require significant financial costs to achieve control, and are predictors of pediatric chronic obstructive pulmonary disease (COPD). At the same time, we have late diagnosis in many patients for many years, as evidenced by a comparison of official statistics and epidemiological studies, conducted using a standardized method by questionnaire followed by in-depth survey. Conclusions. Creating a unified, automated forms of diagnosis can solve the problem of early detection of chronic diseases of bronchial tubes in children.

Key words: asthma, bronchopulmonary dysplasia, obliterating bronchiolitis, prevalence, quality of diagnostics.

 

References

  1. Bogorod, A.E. Bolezni legkih v svete Mezhdunarodnoi statisticheskoi klassifikacii X peresmotra [Lung disease in the International Statistical Classification X revision] / A.E. Bogorod, S.Yu. Kaganov, N.N. Rozinova // Pul'monologiya detskogo vozrasta: problemy i resheniya [Pulmonology childhood: Problems and solutions] / pod obsch. red. Yu.L. Mizernickogo, A.D. Caregorodceva. — M.; Ivanovo, 2002. — Vyp. 2. — S.11—18.
  2. Kovtun, O.P. Rossiiskaya pediatriya: pervoocherednye zadachi [Pulmonology childhood: Problems and solutions] / O.P. Kovtun // Zdravoohranenie [Health]. — 2013. — Vyp. 1. — S.32—39.
  3. Geppe, N.A. Klassifikaciya klinicheskih form bronholegochnyh zabolevanii u detei [Classification of clinical forms of bronchopulmonary diseases in children] / N.A. Geppe, I.K. Volkov. — M.: Rossiiskoe respiratornoe obschestvo [Russian society of respiratory], 2009. — 18 s.
  4. Bogdanova, A.V. Diagnostika, klinicheskie osobennosti i lechenie bronholegochnoi displazii u detei [Diagnosis, clinical features and treatment of bronchopulmonary dysplasia in children] / A.V. Bogdanova // Bolezni organov dyhaniya. Klinika i lechenie bronholegochnoi displazii u detei [Diseases of the respiratory system. The symptoms and treatment of bronchopulmonary dysplasia in children] / pod red. A.N. Kokosova. — SPb.: Lan', 1999. — S.48—57.
  5. Bogdanova, A.V. Klinika, principy terapii i ishody bronholegochnoi displazii [Clinic, principles of therapy and outcome of bronchopulmonary dysplasia] / A.V. Bogdanova, E.V. Boicova // Rossiiskii medicinskii zhurnal. — 2002. — T. 10, № 5. — S.262—264.
  6. Bogdanova, A.V. Farmakoterapiya pri hronicheskoi obstruktivnoi patologii legkih u detei [Pharmacotherapy in chronic obstructive pulmonary disease in children] / A.V. Bogdanova, E.V. Boicova, G.L. Murygina // Rukovodstvo po farmakoterapii v pediatrii i detskoi hirurgii [Pharmacotherapy in Pediatrics and Pediatric Surgery] / pod red. S.Yu. Kaganova. — M.: Medpraktika, 2002. — T. 1. — S.154—164.
  7. Bogdanova, A.V. Hronicheskaya obstruktivnaya bolezn' legkih u detei [Chronic obstructive pulmonary disease in children] / A.V. Bogdanova, S.V. Starevskaya, S.D. Popov // Hronicheskaya obstruktivnaya patologiya legkih u vzroslyh i detei [Chronic obstructive pulmonary diseases in adults and children] / pod red. A.N. Kokosova. — SPb.: SpecLit, 2004. — S.263—282.
  8. Boicova, E.V. Obliteriruyuschii bronhiolit u detei [Bronchiolitis obliterans in children] / E.V. Boicova // Hronicheskaya obstruktivnaya patologiya u vzroslyh i detei [Chronic obstructive pathology in adults and children] / pod red. A.N. Kokosova. — SPb.: SpecLit, 2004. — S.287—288.
  9. Geppe, N.A. Farmakoekonomicheskie aspekty sovremennoi protivoastmaticheskoi terapii [Pharmacoeconomic aspects of modern anti-asthmatic therapy] / N.A. Geppe, A.V. Karpushkina. S.P. Mairko // Atmosfera. Pul'monologiya i allergologiya [Atmosphere. Pulmonology and Allergology]. — 2002. — № 2(5). — S.45—48.
  10. Nacional'naya programma «Bronhial'naya astma u detei. Strategiya lecheniya i profilaktika» [National program «Bronchial asthma in children. Strategy, treatment and prevention»] / Ros. respiratornoe obschestvo, Pediatr. respiratornoe obschestvo; nauch. red. I.K. Volkov [i dr.]. — 4-e izd., ispr. i dop. — M.: Original-maket, 2012. — 182 s.
  11. Starevskaya, S.V. Bronholegochnaya displaziya u detei (faktory riska formirovaniya, kliniko-rentgenologicheskie osobennosti razlichnoi stepeni tyazhesti zabolevaniya) [Bronchopulmonary dysplasia in children (risk factors of formation, clinical and radiological features of varying severity of disease)]: avtoref. dis. ... kand. med. nauk / Starevskaya Svetlana Valer'evna. — SPb., 2001. — 21 s.
  12. Spichak, T.V. Postinfekcionnyi obliteriruyuschii bronhiolit u detei [Postinfectious bronchiolitis obliterans in children] / T.V. Spichak. — M.: Nauchnyi mir, 2005. — 80 s.
  13. Glowacka, E. Bronchopulmonary dysplasia — early and long-term pulmonary sequelae / E. Glowacka, G. Lis // Pneumonol. Pol. — 2008. — № 76(6). — P.437—445.
  14. Moonnumakal, S.P. Bronchiolitis obliterans in children / S.P. Moonnumakal, L.L. Fan // Curr. Opin. Pediatr. — 2008. — Vol. 20(3). — P.272—800.
  15. Antonov, N.S. Hronicheskie obstruktivnye zabolevaniya legkih. Rasprostranennost', diagnostika, lechenie, profilaktika [Chronic obstructive pulmonary disease. Prevalence, diagnosis, treatment, prevention]: avtoref. dis. ... d-ra med. nauk / Antonov Nikolai Sergeevich. — M., 2002. — 46 c.
  16. Boicova, E.V. Posledstviya bronholegochnoi displazii dlya respiratornogo zdorov'ya detei, podrostkov i molodyh vzroslyh [The consequences of bronchopulmonary dysplasia for respiratory health of children, adolescents and young adults] / E.V. Boicova, A.V. Bogdanova, D.Yu. Ovsyannikov // Voprosy diagnostiki v pediatrii [Problems of diagnosis in pediatrics]. — 2013. — T. 5, № 1. — S.5—11.
  17. Volkov, I.K. Hronicheskaya obstruktivnaya bolezn' legkih: vzglyad pediatra [Chronic obstructive pulmonary disease: a look pediatrician] / I.K. Volkov // Atmosfera. Pul'monologiya i allergologiya: zhurnal dlya praktikuyuschih vrachei [Atmosphere. Pulmonology and Allergology: journal for practitioners]. — 2011. — № 2. — S.2—5.
  18. Davydova, I.V. Formirovanie, techenie i ishody bronholegochnoi displazii u detei [Formation, course and outcomes of bronchopulmonary dysplasia in infants]: avtoref. dis. ... d-ra med. nauk / Davydova Irina Vladimirovna. — M., 2010. — 48 s.
  19. High-resolution CT of chest in children and young adults who were born prematurely: findings in a population-based study / S.M. Aukland, T. Holvorsen, K. Fosse [et al.] // Am. J. Roentgenol. — 2006. — № 187. — P.1012—1018.
  20. Baraldi, E. Chronic lung disease after premature birth / E. Baraldi, M. Filippone // N. Engi. J. Med. — 2007. — № 357. — P.1946—1955.
  21. Global strategy for asthma management and prevention Global initiative for asthma (GINA) // GINA. — 2010. — URL: http://canhgiacduoc.org.vn/SiteData/3/UserFiles/ThongTinYDuoc/HuongdanDieutri/Hen/GINA_Pocket_Adult_2010.pdf
  22. Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report / C.S. Devulapalli, K.С. Carlsen, G. Haland [еt al.] // Allergy. — 2008. — Vol. 63. — P.5.
  23. Doyle, L.W. Respiratory function at age in extremely lou birthweight / very preterm children in Victoria in 1991—1992 / L.W. Doyle // Pediatr. Pulmonol. — 2006. — № 118. — P.108—113.
  24. Bronchopulmonary dysplasia in very low birth weight subjects and lung function in late adolescence / L.W. Doyle, B. Faber, C. Calanan [et al.] // Pediatric. — 2006. — № 118. — P.108—113.
  25. Ellison-Loschmann, L. Socioeconomic status, asthma and chronic bronchitis in a large community-based stady / L. Ellison-Loschmann, J. Sunyer, E. Plana // Eur. Respir. J. — 2007. — Vol. 29. — P.897—905.
  26. Van Gent, R. Poor perception of dyspnea in children with undiagnosed asthma / R. van Gent., L.E.M. van Essen-Zandvliet // Eur. Respir. J. — 2007. — Vol. 30. — P.887—891.
  27. Vrijland, E.J.L.E. Pulmonary function testing in premature infants and infants with bronchopulmonary dysplasia / E.J.L.E. Vrijland, E.J. Dulrman // Eur. Respirу Mon. — 2010. — № 47. — P.251—262.
  28. Emphysema in yang adult survivors of moderate-to-severe bronchopulmonary dysplasia / P.M. Wong, A.N. Lees, N. French [et al.] // Eur. Respirу J. — 2008. — № 32. — P.321—328.
  29. Alekseevskih, Yu.G. Strukturno-funkcional'nye osobennosti krupnyh i melkih bronhov i razlichiya voznikayuschih v nih vospalitel'nyh reakcii [Structural and functional features of the large and small bronchi and differences arising in these inflammatory reactions] / Yu.G. Alekseevskih, I.K. Esipova // Arhiv patologii. — 1994. — № 4. — S.6—9.
  30. Epidemiologicheskie podhody k izucheniyu rasprostranennosti recidiviruyuschih i hronicheskih bronholegochnyh zabolevanii u detei na primere Sankt-Peterburga: metod. rekomendacii [Epidemiological approaches to the study of the prevalence of recurrent and chronic bronchopulmonary diseases in children by the example of St. Petersburg: guidelines] / A.V. Bogdanova, E.V. Boicova, A.O. Karelin [i dr.]. — SPb., 2004. — 25 s.
  31. Zaiceva, O.V. Bronhoobstruktivnyi sindrom [Bronchial obstruction] / O.V. Zaiceva // Infekciya respiratornogo trakta u detei rannego vozrasta [In Respiratory tract infections in infants] / pod red. G.A. Samsyginoi. — M., 2006. — C.279.
  32. Goloborod'ko, M.M. Rasprostranennost' i faktory riska formirovaniya boleznei melkih bronhov u detei na primere g. Sankt-Peterburga i Leningradskoi oblasti [Prevalence and risk factors for the formation of small airways disease in children by the example of St. Petersburg and Leningrad region]: dis. ... kand. med. nauk / Goloborod'ko Mariya Mihailovna — SPb., 2009. — 15 s.
  33. Gosudarstvennyi doklad o sostoyanii zdorov'ya naseleniya Rossiiskoi Federacii v 2005 g. [State report on the health status of the population of the Russian Federation in 2005] // Zdravoohranenie Rossiiskoi Federacii [Health of the Russian Federation]. — 2007. — № 5. — C.3—34.
  34. 2010 Child Asthma Data: Prevalence Tables [electronic resource] // Centers for Disease Control and Prevention. — 2010. —URL: http: www.cdc.gov/asthma/brfss/2010/child/lifetime/tablek/htm
  35. Truncova, E.S. Rasprostranennost' hronicheskih i recidiviruyuschih nespecificheskih zabolevanii legkih v Yuzhnom regione strany (g. Astrahan') [The prevalence of chronic and recurrent nonspecific pulmonary diseases in the Southern region of the country (Astrakhan)]: avtoref. dis. ... kand. med. nauk / Truncova Evgeniya Semenovna. — SPb., 2005. — C.7—16.
  36. Gaiduk, I.M. Respiratornaya allergiya u detei: epidemiologiya, sovremennyi podhod k terapii i profilaktike [Respiratory allergies in children: epidemiology, modern approach to therapy and prevention]: avtoref. dis. ... d-ra med. nauk / Gaiduk Irina Mihailovna. — SPb., 2013. — 35 s.
  37. Zabolevaemost' detskogo naseleniya Rossii v 2011 g.: stat. materialy / Ministerstvo zdravoohraneniya i social'nogo razvitiya [The incidence of child population in Russia in 2011 statistics.The Ministry of Health Social Development]. — M., 2012. — ch. 5. — 144 s.

 

PDF downloadDuodenogastric reflux as a cause of reflux-gastritis

Shamil Z. Galiev, graduate student of Department of general practice of SBEI HPE «Kazan State Medical University», Kazan, Russia, tel. 8-927-421-03-08, e-mail: galis160@gmail.com

Nail B. Amirov, D.Med.Sci., professor of Department of general practice of SBEI HPE «Kazan State Medical University», Kazan, Russia, tel. 8-905-313-01-11

Abstract. Aim. The purpose of the study is to look into the problem of duodenogastric reflux (DGR) among different categories of patients. And also to identify consequences of the disease. Material and methods. The literature review shows different existing positions on pathophysiological mechanisms of the DGR and development of reflux gastritis. The main attention is paid on of the articles pointing on the link between DGR and the development of precancerous changes in the gastric mucosa. Comparison of different surveys on how biliary reflux affects H. Pylori displays controversy in their data. Results. Mainly it’s because the clinical picture of DGR has no specific symptoms, so generally the diagnosis is based on instrumental methods of research. Conclusion. It is known than different groups of drugs are used in the treatment of the DGR and reflux gastritis. Nevertheless their efficiency has not been studied uniformly. And the generally accepted regimen for this illness seems has not been found yet. It is shown the validity of UDCA prescription for DGR treatment.

Key words: duodenal reflux, reflux gastritis, intestinal metaplasia, UDCA.

 

References

  1. Pimanov, S.I. Gastrit, ezofagit i yazvennaya bolezn' [Gastritis, esophagitis and peptic ulcer] / S.I. Pimanov. — N. Novgorod: Izd-vo NGMA. — 2000. — 380 s.
  2. Mihas'kiv, I.N. Rol' reflyuksa duodenal'nogo soderzhimogo v geneze raka kul'ti zheludka posle rezekcii zheludka [The role of reflux of duodenal contents in the genesis of cancer of the gastric stump after gastrectomy] / I.N. Mihas'kiv // Hirurgiya [Surgery]. — 1980. — № 2. — S.44—51.
  3. Vahrushev, Ya.M. Kompleksnoe izuchenie patogene- ticheskih mehanizmov erozivnogo porazheniya zheludka i dvenadcatiperstnoi kishki [Comprehensive study of pathogenetic mechanisms of erosive lesions of the stomach and duodenum] / Ya.M. Vahrushev, E.V. Nikishina // Pocsiiskii gastroenterologicheskii zhurnal [Russian Journal of Gastroenterology]. — 1998. — № 3. — S.22—29.
  4. Sannikov, O.R. Optimizaciya diagnostiki duodeno- gastral'nogo reflyuksa posle holecistektomii [Optimizing the diagnosis of duodenal reflux after cholecystectomy]: avtoref. dis. ... kand. med. nauk / O.R. Sannikov. — Perm', 2007. — 22 s.
  5. Babak, O.Ya. Zhelchnyi reflyuks: sovremennye vzglyady na patogenez i lechenie [Bile reflux: current views on the pathogenesis and treatment] / O.Ya. Babak // Suchasna gastroenterologiya [Modern Gastroenterology]. — 2003. — № 1(11). — S.28—30.
  6. Aruin, L.I. Morfologicheskaya diagnostika boleznei zheludka i kishechnika [Morphological diagnosis of diseases of the stomach and intestines] / L.I. Aruin, L.L. Kapuller, V.A. Isakov. — M.: Triada-H, 1998. — 496 s.
  7. Goncharik, I.I. Klinicheskaya gastroenterologiya [Clinical Gastroenterology] / I.I. Goncharik. — Minsk: Interpresservis, 2002. — 334 s.
  8. Volkov, V.S. Duodenogastral'nyi reflyuks i yazvennaya bolezn' dvenadcatiperstnoi kishki — rasstavim tochki nad «i» [Duodenal reflux and duodenal ulcer — dot the «i»] / V.S. Volkov, I.Yu. Kolesnikova // Verhnevolzhskii medicinskii zhurnal [Verhnevolzhskiy Medical Journal]. — 2010. — T. 8, № 1. — S.26—29.
  9. Kolesnikova, I.Yu. Pochemu ne voznikaet yazva dvenadcatiperstnoi kishki u bol'nyh hronicheskim gastroduodenitom? [Why is not there a duodenal ulcer in patients with chronic gastroduodenitis?] / I.Yu. Kolesnikova, V.S. Volkov, E.K. Lukasheva // Rossiiskie medicinskie vesti [Russian Medical News]. — 2012. — T. XVII., № 3. — S.69—72.
  10. Kolesnikova, I.Yu. Osobennosti duodenogastral'nogo reflyuksa pri yazvennoi bolezni dvenadcatiperstnoi kishki i ego dinamika posle eradikacii Helicobacter pylori [Features of duodenogastric reflux with duodenal ulcer and its dynamics after Helicobacter pylori eradication] / I.Yu. Kolesnikova, V.S. Volkov, L.A. Lyubskaya // Eksperimental'naya i klinicheskaya gastroenterologiya [Experimental and Clinical Gastroenterology ]. — 2011. — № 5. — S.16—19.
  11. Pan'ko, S.V. Znachenie sutochnogo rN-monitorirovaniya v diagnostike reflyuksnoi patologii zheludochno-kishechnogo trakta [Meaning of daily pH monitoring in diagnosing reflux diseases of the gastrointestinal tract] / S.V. Pan'ko, G.A. Zhurbenko, A.S. Karpickii [i dr.] // Biologicheskie ritmy: materialy Mezhdunar. nauch.-prakt. konf. 11—12 okt. 2012 g. [Biological rhythms: Materials intern. scientific and practical. conference]. — Brest, 2012. — S.147—149.
  12. Osipenko, M.F. Podhody k diagnostike i terapii gastrita, associirovannogo s reflyuksom zhelchi [Approaches to diagnosis and treatment of gastritis associated with bile reflux] / M.F. Osipenko, M.A. Livzan // Lechaschii vrach [Treating physician]. — 2012. — № 2. — S.50—53.
  13. Bueverov, A.O. Duodenogastroezofageal'nyi reflyuks kak prichina reflyuks-ezofagita [Duodenogastroesophageal reflux as a reason of reflux oesophagitis] / A.O. Bueverov, T.L. Lapina // Farmateka. — 2006. — № 1. — S.1—5.
  14. Zvyaginceva, T.D. Hronicheskaya duodenal'naya neprohodimost' i principy konservativnoi terapii [Chronic duodenal obstruction and principles of conservative therapy] / T.D. Zvyaginceva, I.I. Shargorod // Novosti mediciny i farmacii. Gastroenterologiya (tematicheskii nomer) [News of medicine and pharmacy. Gastroenterology]. — 2011. — № 367 (gazeta). — URL: http://www.mif-ua.com (data obrascheniya 26.10.2014).
  15. Zvyaginceva, T.D. Duodenogastral'nyi reflyuks v praktike vracha-gastroenterologa: ochevidnye opasnosti i skrytaya ugroza [Duodenogastric reflux in practice of Gastroenterologist: obvious dangers and hidden threat] / T.D. Zvyaginceva, A.I. Chernobai // Zdorov'e Ukrainy. — 2012. — № 3. — S.11.
  16. Yurchenko, I.N. Duodenogastral'nyi reflyuks pri gastroezofageal'noi reflyuksnoi bolezni [Duodenogastric reflux with gastroesophageal reflux disease] / I.N. Yurchenko, N.A. Kashirina, N.A. Vlasova // Materialy XVII rossiiskoi gastronedeli [Materials XVII Russian gastro week] // RZHGGK. — 2011. — № 5, pril. 38. — C.19.
  17. Selezneva, E.Ya. Vnutrizheludochnaya rN-metriya v ocenke sekretornyh i motornyh narushenii zheludka [Intragastric pH-metry in the evaluation of secretory and motor disorders of the stomach] / E.Ya. Selezneva // Rossiiskii gastroenterologicheskii zhurnal [Russian Journal of Gastroenterology]. — 1998. — № 4 — S.69—72.
  18. Gibadulina, I.O. Vozmozhnosti ul'trazvukovoi ocenki funkcional'nyh rezul'tatov hirurgicheskoi korrekcii duodenogastral'nogo reflyuksa [Ultrasound evaluation of the functional capabilities of the results of surgical correction of duodenogastric reflux] / I.O. Gibadulina, N.V. Gibadulin // SonoAce-Ultrasound. — 2011. — № 22 (med. zhurnal). — URL: http://www.medison.ru/si/
  19. Rukovodstvo po ul'trazvukovoi diagnostike zabolevanii pischevoda, zheludka i dvenadcatiperstnoi kishki [Guide to the ultrasound diagnosis of diseases of the esophagus, stomach and duodenum] / pod red. G.K. Zherlova, S.A. Sokolova. — Novosibirsk: Nauka, 2005. — 208 s.
  20. Belousov, S.S. Gastroezofageal'naya reflyuksnaya bolezn' i duodenogastral'nyi reflyuks [Gastroesophageal reflux disease and duodenogastric reflux] / S.S. Belousov, S.V. Muratov, A.M. Ahmad. — N. Novgorod: Izd-vo Nizhegorodskoi gos. med. akademii, 2005. — 120 s.
  21. Lapchenko, E.S. Sostoyanie slizistoi obolochki zheludka u bol'nyh s duodenogastral'nym reflyuksom [Condition of the gastric mucosa in patients with duodeno-gastric reflux] / E.S. Lapchenko, T.M. Preobrazhenskaya, E.V. Galaeva, I.D. Loranskaya // Eksperimental'naya i klinicheskaya gastroenterologiya [Experimental and Clinical Gastroenterology]. — 2010. — № 9. — S.25—29.
  22. Ivashkin, V.T. Mesto antacidov v sovremennoi terapii yazvennoi bolezni [The place of antacids in modern therapy of peptic ulcer] / V.T. Ivashkin, E.K. Baranskaya, O.S. Shifrin, E.Yu. Yur'eva // Russkii medicinskii zhurnal. Bolezni organov pischevareniya [Russian Medical Journal. Diseases of the digestive]. — 2002. — T. 4, № 2. — URL: http://www.rmj.ru/
  23. Chen, S.L. Effects of bile reflux on gastric mucosal lesions in patients with dyspepsia or chronic gastritis / S.L. Chen, J.Z. Mo, Z.J. Cao [et al.] // World J. Gastroenterol. — 2005. — Vol. 11, № 18. — P.2834—2847.
  24. Abe, H. Influence of bile reflux and Helicobacter pylori infection on gastritis in the remnant gastric mucosa after distal gastrectomy / H. Abe, K. Murakami, S. Satoh [et al.] // J. Gastroenterol. — 2005. — Vol. 40, № 6. — P.563—569.
  25. Hanninen, M.L. Sensitivity of Helicobacter pylori to different bile salts / M.L. Hanninen // Eur. J. Clin. Microbiol. Infect. Dis. — 1991. — Vol. 10. — P.515—518.
  26. Caldwell, M.T.P. Helicobacter pylori infection increases following cholecystectomy / M.T.P. Caldwell, M. McDermott, S. Jazrawi [et al.] // Ir. J. Med. Sci. — 1995. — Vol. 164. — P.52—55.
  27. Chen, D.F. H. pylori exist in the gallbladder mucosa of patients with chronic cholecystitis / D.F. Chen, L. Hu, P. Yi, D.C. Fang [et al.] // World J. Gastroenterol. — 2007. — Vol. 13, № 10. — P.1608—1611.
  28. Bechi, P. Are there alternative methods for measuring «bile» reflux? / P. Bechi, F. Pucciani, F. Baldini [et al.] // Dig. Dis. Sci. — 1993. — Vol. 38, № 7. — P.1297—1306.
  29. Lin, J.K. A study of diagnosis of primary biliary reflux gastritis / J.K. Lin, P.J. Hu, C.J. Li [et al.] // Zhonghua Nei Ke Za Zhi. — 2003. — Vol. 42, № 2. — P.81—83.
  30. Vere, C.C. Endoscopical and histological features in bile reflux gastritis / C.C. Vere, S. Cazacu, V. Comănescu [et al.] // Rom. J. Morphol. Embryol. — 2005. — Vol. 46, № 4. — P.269—274.
  31. Li, X.B. Role of bile reflux and Helicobacter pylori infection on inflammation of gastric remnant after distal gastrectomy / X.B. Li, H. Lu, H.M. Chen [et al.] // J. Dig. Dis. — 2008. — Vol. 9, № 4 — P.208—212.
  32. Sjövall, H. Meaningful or redundant complexity — mechanisms behind cyclic changes in gastroduodenal pH in the fasting state / H. Sjövall // Acta Physiol (Oxf). — 2011. — Vol. 201, № 1. — P.127—131.
  33. Zullo, A. Gastric Pathology in Cholecystectomy Patients: Role of Helicobacter pylori and Bile Reflux / A. Zullo, V. Rinaldi, C. Hassan [et al.] // Journal of Clinical Gastroenterology. — 1998. — Vol. 27, № 4. — P.335—338.
  34. Ladas, S.D. Helicobacter pylori may induce bile reflux: link between H. pylori and bile induced injury to gastric epithelium / S.D. Ladas, J. Katsogridakis, H. Malamou [et al.] // Gut. — 1996. — Vol. 38, № 1. — P.15—18.
  35. Fall, K. Risk for Gastric Cancer After Cholecystectomy / K. Fall, W. Ye, O. Nyren // The American Journal of Gastroenterology. — 2007. — Vol. 102, № 6. — P.1180—1184.
  36. Mac Dowall, J.E. Cell proliferation in type C gastritis affecting the intact stomach / J.E. Mac Dowall, P. Willis, R. Prescott [et al.] // Clin. Pathol. — 2000. — Vol. 53. — P.784—787.
  37. Fuchs, K.H. The role of 24-hr gastric pH-monitoring in the interpretation of 24-hr gastric bile monitoring for duodenogastric reflux / K.H. Fuchs, M. Fein, J. Maroske [et al.] // Hepatogastroenterology. — 1999. — Vol. 46, № 25. — P.60—65.
  38. Tibbling, G.L. Gastric bile monitoring: an in vivo and in vitro study of Bilitec reliability / G.L. Tibbling, L. Blackadder, T. Franzén, E. Kullman // Scand. J. Gastroenterol. — 2002. — Vol. 37, № 11. — P.1334—1337.
  39. Bechi, P. Technical aspects and clinical indications of 24-hour intragastric bile monitoring / P. Bechi, F. Cianchi // Hepatogastroenterology. — 1999. — Vol. 46, № 25. — P.54—59.
  40. Sobala, G.M. Bile reflux and intestinal metaplasia in gastric mucosa / G.M. Sobala, H.J. O'Connor, E.P. Dewar [et al.] // J. Clin. Pathol. — 1993. — Vol. 46. — P.235—240.
  41. Dixon M.F. Bile reflux gastritis and intestinal metaplasia at the cardia / M.F. Dixon, N.P. Mapstone, P.M. Neville [et al.] // Gut. — 2002. — Vol. 51. — P.351—355.
  42. Matsuhisa, T. Relation between bile acid reflux into the stomach and the risk of atrophic gastritis and intestinal metaplasia: a multicenter study of 2283 cases / T. Matsuhisa, T. Arakawa, T. Watanabe [et al.] // Dig. Endosc. — 2013. — Vol. 25, № 5. — P.519—525.
  43. Xu, Y. Bile Acids Induce Cdx2 Expression Through the Farnesoid X Receptor in Gastric Epithelial Cells / Y. Xu, T. Watanabe, T. Tanigawa [et al.] // J. Clin. Biochem. Nutr. — 2010. — Vol. 46, № 1. — P.81—86.
  44. Tatsugami, M. Bile acid promotes intestinal meta- plasia and gastric carcinogenesis. / M. Tatsugami, M. Ito, S. Tanaka [et al.] // Cancer Epidemiol Biomarkers Prev. — 2012. — Vol. 21, № 11. — P.2101—2107.
  45. Aprea, G. Morpho-functional gastric pre-and post- operative changes in elderly patients undergoing laparoscopic cholecystectomy for gallstone related disease / G. Aprea, A. Canfora, A. Ferronetti [et al.] // BMC Surg. — 2012. — Vol. 12, № 1. — P.5.
  46. Kuran, S. Bile reflux index after therapeutic biliary procedures / S. Kuran, E. Parlak, G. Aydog [et al.] // BMC Gastroenterol. — 2008. — Vol. 8. — P.4.
  47. Atak, I. The effect of laparoscopic cholecystectomy on the development of alkaline reflux gastritis and intestinal metaplasia / I. Atak, K. Ozdil, M. Yücel [et al.] // Hepatogastroenterology. — 2012. — Vol. 59, № 113. — P.59—61.
  48. Chen, T.-F. Comparative evaluation of intragastric bile acids and hepatobiliary scintigraphy in the diagnosis of duodenogastric reflux / T.-F. Chen, P.K. Yadav, R.-J. Wu [et al.] //World J. Gastroenterol. — 2013. — Vol. 19, № 14. — P.2187—2196.
  49. Menges, M. Increased acid and bile reflux in Barrett’s oesophagus compared to reflux oesophagitis, and effect of proton pump inhibitor therapy / M. Menges, M. Muller, M. Zeitz // Am. J. Gastroenterol. — 2001. — Vol. 96. — P.331—337.
  50. Chen, H. Rabeprazole combined with hydrotalcite is effective for patients with bile reflux gastritis after cholecystectomy / H. Chen, X. Li, Z. Ge [et al.] // Can. J. Gastroenterol. — 2010. — Vol. 24, № 3. — P.197—201.
  51. Vinter-Jensen, L. A double-blind placebo-controlled trial of omeprazole on characteristics of the migrating motor complex in healthy volunteers / L. Vinter-Jensen, K. Kraglund, S.A. Pedersen // Aliment. Pharmacol. Ther. — 1989. — Vol. 3, № 6. — P.615—620.
  52. Stefaniwsky, A.B. Ursodeoxycholic acid treatment of bile reflux gastritis. / A.B. Stefaniwsky, G.S. Tint, J. Speck [et al.] // Gastroenterology. — 1985. — Vol. 89, № 5. — P.1000—1004.
  53. Ozkaya, M. The effect of ursodeoxycholic acid treat- ment on epidermal growth factor in patients with bile ref- lux gastritis / M. Ozkaya, A. Erten, I. Sahin [et al.] // Turk. J. Gastroenterol. — 2002. — Vol. 13, № 4. — P.198—202.
  54. Thao, T.D. Antibacterial and anti-atrophic effects of a highly soluble, acid stable UDCA formula in Helicobacter pylori-induced gastritis / T.D. Thao, H.C. Ryu, S.H. Yoo [et al.] // Biochem. Pharmacol. — 2008. — Vol. 75, № 11. — P.2135—2146.
  55. Kawamura, T. Effect of ursodeoxycholic acid on water immersion restraint stress ulcer of rats / T. Kawa- mura, F. Koizumi, A. Ishimori // Nihon Shokakibyo Gakkai Zasshi. — 1989. — Vol. 86, № 10. — P.2373—2378.
  56. Kawiorski, W. Current diagnosis of gastroduodenal reflux and biliary gastritis / W. Kawiorski, R.M. Herman, J. Legutko // Przegl. Lek. — 2001. — Vol. 58, № 2. — P.90—94.

 

PDF downloadBenefits and harm of electronic cigarettes through the prism of different therapeutic methodologies

Vladimir D. Mendelevich, D.Med.Sci., Professor, Chair of Department of medical and general psychology of SBEI HPE «Kazan State Medical University», Kazan, Russia, tel. +7-843-238-60-74, e-mail: mend@tbit.ru

Abstract. Aim. The article provides an analytical overview of current research on the assessment of benefit and harm of using electronic cigarettes (ES) for nicotine addiction. Material and methods. Analyzed the results of a study of several dozen works carried out in the design of evidence-based research. Results. It is concluded that the evaluation of the effectiveness depends on what kind of therapeutic paradigm adheres the researcher — the strategy of «zero tolerance» or «harm reduction». In the first case, the positive impact is assessed solely on the basis of complete smoking cessation (both conventional and electronic cigarettes), the second — using criteria of reduced harmful effects of smoking. Attention is drawn to the fact that physicians have a relationship with real patients; most of them did not wish to give up smoking and will continue to smoke despite the obvious health risks. Conclusion. It is noted that nicotine addiction is one of the most severe and resistant to therapy, and on the severity of the addictive potential of nicotine is in third place out of fifteen drugs, second only to heroin and crack. This necessitates the use in evaluating the effectiveness of ES criteria of harm reduction strategies.

Key words: e-cigarettes, therapy, harm reduction.

 

References

  1. Amirov, N.B. Tabachnaya epidemiya: farmakologicheskie vozmozhnosti bor'by [Tobacco epidemic: pharmacological possibilities of struggle] / N.B. Amirov, T.I. Andreeva // Vestnik sovremennoi klinicheskoi mediciny [ Bulletin of Contemporary Clinical Medicine]. — 2011. — T. IV, vyp. 3. — S.28—33.
  2. Elektronnye sigarety: ocenka bezopasnosti i riskov dlya zdorov'ya [Electronic cigarettes: to assess the safety and health risks] / N.S. Antonov, G.M. Saharova, V.V. Donitova [i dr.] // Pul'monologiya [Pulmonology]. — 2014. — № 3. — S.123—127.
  3. Zobin, M.L. Snizhenie vreda pri alkogol'nyh problemah: rasshirenie vozmozhnostei lecheniya [Harm reduction for alcohol problems: the empowerment of treatment] / M.L. Zobin // Nevrologicheskii vestnik. — 2014. — № 1, ch. 2. — S.65—73.
  4. Ivanec, N.N. Narkologiya — predmet i zadachi. Sovremennaya koncepciya terapii narkologicheskih zabolevanii [Drug Addiction — subject and objectives. The modern concept of treatment of substance abuse] / N.N. Ivanec // Lekcii po narkologii [Lectures on Addictions]. — M.: Nolidzh, 2000. — S.7—15.
  5. Marcevich, S.Yu. Problema tabakokureniya v Rossii. Medikamentoznaya terapiya nikotinovoi zavisimosti: novye i starye preparaty s pozicii dokazatel'noi mediciny [The problem of smoking in Russia. Drug therapy of nicotine dependence: new and old drugs from the standpoint of evidence-based medicine] / S.Yu. Marcevich, Yu.V. Lukina // Profilakticheskaya medicina [Preventive Medicine]. — 2010. — № 6. — S.24—28.
  6. Mendelevich, V.D. Rasstroistva zavisimogo povedeniya (k postanovke problemy) [Dependent behavior disorder (to the problem)] / V.D. Mendelevich // Rossiiskii psihiatricheskii zhurnal [Russian Journal of Psychiatry]. — 2003. — № 1. — S.5—9.
  7. Mendelevich, V.D. Sovremennaya rossiiskaya narkologiya: paradoksal'nost' principov i nebezuprechnost' procedur [Modern Russian drug and alcohol abuse: the paradox of the principles and procedures of the faulty] / V.D. Mendelevich // Narkologiya [Drug Addiction]. — 2005. — № 1. — S.56—64.
  8. Mendelevich, V.D. Psihopatologizaciya narko- logicheskih rasstroistv kak dominiruyuschaya paradigma otechestvennoi narkologii [Psihopatologizatsiya substance abuse disorders as the dominant paradigm of the national Addiction] / V.D. Mendelevich // Nezavisimyi psihiatricheskii zhurnal [Independent Journal of Psychiatry]. — 2010. — № 3. — S.21—27.
  9. Mendelevich, V.D. Kal'yanokurenie: medicinskie, sociokul'turnye i psihologicheskie aspekty [Hookah smoking: health, socio-cultural and psychological aspects] / V.D. Mendelevich // Narkologiya [Drug Addiction]. — 2014. — № 12. — S.56—63.
  10. Prekraschenie potrebleniya tabaka i lechenie tabachnoi zavisimosti: nauchno obosnovannye rekomendacii [Cessation of tobacco use and treatment of tobacco dependence. Evidence-based recommendations] / pod red. A.K. Demina. — M.; Vashington, 2013. — 244 s.
  11. Saharova, G.M. Okazanie pomoschi po otkazu ot tabaka v terapevticheskoi praktike [On the question of rational treatment in Addiction]: ucheb. posobie / G.M. Saharova, N.S. Antonov. — M., 2010. — 58 s.
  12. Sivolap, Yu.P. K voprosu o racional'nom lechenii v narkologii [On the question of rational treatment in Addiction] / Yu.P. Sivolap // Narkologiya [Drug Addiction]. — 2011. — № 12. — S.79—81.
  13. Speranskaya, O.I. Pervichnaya i vtorichnaya terapevticheskaya rezistentnost' k nikotinzamestitel'noi terapii u lic s tabachnoi zavisimost'yu [Primary and secondary treatment resistance to nicotine replacement therapy in patients with tobacco dependence] / O.I. Speranskaya, V.K. Smirnov, K.A. Bogdanov // Zhurnal nevrologii i psihiatrii im. S.S. Korsakova [Journal of Neurology and Psychiatry named after S.S. Korsakov]. — 2013. — № 9. — S.59—62.
  14. Elektronnye sistemy dostavki nikotina: doklad VOZ [Electronic Systems transmit nicotine. WHO report]. — M., 2014. — URL: http://apps.who.int/gb/fctc/PDF/cop6/FCTC_COP6_10-ru.pdf
  15. Adkison, S.E. Electronic nicotine delivery systems: international tobacco control four-country survey / S.E. Adkison, R.J. O’Connor, M. Bansal-Travers [et al.] // Am. J. Prev. Med. — 2013. — Vol. 44. — P.207—215.
  16. Adriaens, K. Effectiveness of the electronic cigarette: An eight-week flemish study with six-month follow-up on smoking reduction, craving and experienced benefits and complaints / K. Adriaens, D. Van Gucht, P. Declerck [et al.] // Int. J. Environ Res. Public. Health. — 2014. — Vol. 11(11). — P.11220—11248.
  17. Baker, T.B. Treating Smokers in the Health Care Setting / T.B. Baker // N. Engl. J. Med. — 2011. — Vol. 365. — P.1222—1231.
  18. Barbeau, A.M. Perceived efficacy of e-cigarettes versus nicotine replacement therapy among successful e-cigarette users: a qualitative approach / A.M. Barbeau, J. Burda, M. Siegel // Addiction Science & Clinical Practice. — 2013. — Vol. 8. — P.5.
  19. Berg, C.J. Attitudes toward E-Cigarettes, Reasons for Initiating E-Cigarette Use, and Changes in Smoking Behavior after Initiation: A Pilot Longitudinal Study of Regular Cigarette Smokers / C.J. Berg, D.B. Barr, E. Stratton [et al.] // Open J. Prev. Med. — 2014. — Vol. 4(10). — P.789—800.
  20. Blasi, F. Electronic nicotine delivery systems (ENDS): the beginning of the end or the end of the beginning? / F. Blasi, M. Ward // Eur. Respir. J. — 2014. — Vol. 44(3). — P.585—588.
  21. Borderud, S.P. Electronic cigarette use among patients with cancer: characteristics of electronic cigarette users and their smoking cessation outcomes/ S.P. Borderud, Y. Li, J.E. Burkhalter [et al.] // Cancer. — 2014. — Vol. 120(22). — P.3527—3535.
  22. Brandon, T.H. Electronic Nicotine Delivery Systems: A Policy Statement from the American Association for Cancer Research and the American Society of Clinical Oncology / T.H. Brandon, M.L. Goniewicz, N.H. Hanna [et al.] // Clin. Cancer Res. — 2015.
  23. Breland, A.B. Youth smoking cessation interventions: Treatments, barriers, and recommendations for Virginia / A.B. Breland, S. Colby, G. Dino [et al.]. — Richmond, Virginia: Virginia Commonwealth University, Institute for Drug and Alcohol Studies, 2009. — URL: http://www.vcu.edu/idas/vytp/reports/index.html
  24. BMA response to the WHO report into e-cigarettes. — 2014. — URL: http://web2.bma.org.uk/pressrel.nsf/wall/258CF3FDC71A2A6480257D410033523D?OpenDocument
  25. Boyle, R. Use of electronic health records to support smoking cessation / R. Boyle, L. Solberg, M. Fiore // Cochrane Database of Systematic Reviews. — 2014, Issue 12. — Art. № CD008743.
  26. Brown, J. Real-world effectiveness of e-cigarettes when used to aid smoking cessation: a cross-sectional population study / J. Brown, E. Beard, D. Kotz [et al.] // Addicition. — 2014. — Vol. 109(9). — P.1531—1540.
  27. Bullen, C. Electronic cigarettes for smoking cessation: a randomised controlled trial / C. Bullen, C. Howe, M. Laugesen [et al.] // Lancet. — 2013. — Vol. 382(9905). — P.1629—1637.
  28. Bullen, C. Effect of an electronic nicotine deli- very device (e cigarette) on desire to smoke and with- drawal, user preferences and nicotine delivery: rando- mised cross-over trial / C. Bullen, H. McRobbie, S. Thorn- ley [et al.] // Tob. Control. — 2010. — Vol. 19. — P.98—103.
  29. Cahill, K. Nicotine receptor partial agonists for smoking cessation / K. Cahill, L.F. Stead, T. Lancaster // Cochrane Database of Systematic Reviews. — 2013. — Issue 6. — Art. № CD006103. DOI: 10.1002/14651858.CD006103.pub6.
  30. Cahill, K. Pharmacological interventions for smoking cessation: an overview and network meta-analysis / K. Cahill, S. Stevens, R. Perera [et al.] // Cochrane Database of Systematic Reviews. — 2013. — Issue 5. — Art. № CD009329. DOI: 10.1002/14651858.CD009329.pub2.
  31. Cahn, Z. Electronic cigarettes as a harm reduction strategy for tobacco control: A step forward or a repeat of past mistakes? / Z. Cahn, M. Siegel // J. Public Health Policy. — 2010. — Vol. 32.
  32. Callahan-Lyon, P. Electronic cigarettes: human health effects / P. Callahan-Lyon // Tob. Control. — 2014. — Vol. 23. — ii36—ii40.
  33. Callinan, J.E. Legislative smoking bans for reducing secondhand smoke exposure, smoking prevalence and tobacco consumption / J.E. Callinan, A. Clarke, K. Doherty [et al.] // Cochrane Database of Systematic Reviews. — 2010. — Issue 4. — Art. № CD005992.
  34. Caponnetto, P. The emerging phenomenon of electronic cigarettes / P. Caponnetto, D. Campagna, G. Papale [et al.] // Expert Rev. Respir. Med. — 2012. — Vol. 6(1). — P.63—74.
  35. Caponnetto, P. Efficiency and Safety of an electronic cigarette (ECLAT) as Tobacco Cigarettes Substitute: A Prospective 12-Month Randomized Control Design Study / P. Caponnetto, D. Campagna, F. Cibella [et al.] // PLOS. — 2013. — Vol. 8(6). — P.e66317.
  36. Caponnetto, P. Effect of a nicotine free inhalator as part of a smoking cessation program P. Caponnetto, F. Cibella, S. Mancuso [et al.] // Eur. Respir. J. — 2011. — Vol. 38(5). — P.1005—1011.
  37. Carroll Chapman, S.L. E-cigarette prevalence and correlates of use among adolescents versus adults: a review and comparison / S.L. Carroll Chapman, L.T. Wu // J. Psychiatr. Res. — 2014. — Vol. 54. — P.43—54.
  38. Christensen, T. Profile of e-cigarette use and its relationship with cigarette quit attempts and abstinence in Kansas adults / T. Christensen, E. Welsh, B. Faseru // Prev. Med. — 2014. — Vol. 69. — P.90—94.
  39. Courtwright, D.T. The NIDA brain disease paradigm: History, resistance and spinoffs / D.T. Courtwright // BioSocieties. — 2010. — Vol. 5.(1). — P.137—147.
  40. David, S.P. Opioid antagonists for smoking cessation / S.P. David, T. Lancaster, L.F. Stead [et al.] // Cochrane Database of Systematic Reviews. — 2013. — Issue 6. — Art. № CD003086. DOI: 10.1002/14651858.CD003086.pub3.
  41. Dawkins, L. The electroniccigarette: effects on desire to smoke, withdrawal symptoms and cognition / L. Dawkins, J. Turner, S. Hasna [et al.] // Addict. Behav. — 2012. — Vol. 37. — P.970—973.
  42. Dockrell, M. E-Cigarettes: Prevalence and Attitudes in Great Britain / M. Dockrell [et al.] // Nicotine & Tobacco Research. — 2013. — Vol. 15(10). — P.1737—1744.
  43. Drummond, M.B. Electronic cigarettes. Potential harms and benefits / M.B. Drummond, D. Upson // Ann. Am. Thorac. Soc. — 2014. — Vol. 11(2). — P.236—242.
  44. Durcan, M.J. The effect of bupropion sustained-release on cigarette craving after smoking cessation / M.J. Durcan, G. Deener, J. White [et al.] // Clin. Ther. — 2002. — Vol. 24. — P.540—551.
  45. Etter, J.F. Electronic cigarette: users profile, utilization, satisfaction and perceived efficacy / J.F. Etter, C. Bullen // Addiction. — 2011. — Vol. 106(11). — P.2017—2028.
  46. Etter, J.F. A longitudinal study of electronic cigarette users / J.F. Etter, C. Bullen // Addict. Behav. — 2014. — Vol. 39. — P.491—494.
  47. Fagerstrom, K. Determinants of tobacco use and renaming the FTND to the Fagerstrom Test for Cigarette Dependence / K. Fagerstrom // Nicotine Tob. Res. — 2012. — Vol. 14(1). — P.75—78.
  48. Farsalinos, K.E. Safety evaluation and risk assessment of electronic cigarettes as tobacco cigarette substitutes: a systematic review / K.E. Farsalinos, R. Polosa // Ther Adv. Drug. Saf. — 2014. — Vol. 5(2). — P.67—86.
  49. Fiore, M.C. Treating tobacco use and dependence: 2008 update / M.C. Fiore, C.R. Jaen, T.B. Baker [et al.]. — Rockville M.D.: Department of Health and Human Services, U.S. — Public Health Service, 2008.
  50. Franck, C. Electronic cigarettes in North America: history, use, and implications for smoking cessation / C. Franck, T. Budlovsky, S.B. Windle [et al.] // Circulation. — 2014. — Vol. 129(19). — P.1945—1952.
  51. Goniewicz, M.L. Levels of selected carcinogens and toxicants in vapour from electronic cigarettes / M.L. Goniewicz, J. Knysak, M. Gawron [et al.] // Tob. Control. — 2014. — Vol. 23. — P.133—139.
  52. Gonzales, D. Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs sustained-release Bupropion and placebo for smoking cessation: a randomized controlled trial / D. Gonzales, S.I. Rennard, M. Nides [et al.] // JAMA. — 2006. — Vol. 296. — P.47—55.
  53. Gourlay, S.G. Clonidine for smoking cessation / S.G. Gourlay, L.F. Stead, N. Benowitz // Cochrane Tobacco Addiction Group. Published Online. — Assessed as up-to-date: 15 JUN. — 2008 DOI: 10.1002/14651858.CD000058.pub2
  54. Grana, R. A longitudinal analysis of electronic cigarette use and smoking cessation / R. Grana, L. Popova, P. Ling // JAMA Int. Med. — 2014. — Vol. 187.
  55. Grana, R. E-Cigarettes: A Scientific Review / R. Grana, N. Benowitz, S. Glantz // Circulation. — 2014. — Vol. 129. — P.1972—1986.
  56. Guideline on the development of medicinal products for the treatment of alcohol dependence. European Medicines Agency. — 2010. — URL: http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2010/03/WC500074898.pdf
  57. Harrell, P.T. Electronic nicotine delivery systems («e-cigarettes»): review of safety and smoking cessation efficacy / P.T. Harrell, V.N. Simmons, J.B. Correa [et al.] // Otolaryngol Head Neck Surg. — 2014. — Vol. 151(3). — P.381—393.
  58. Harm Reduction: Concepts and Practices. Available online: www.tobaccoharmreduction. org/faq/harmreduction.htm (accessed on 21 February 2014).
  59. Hughes, J.R. Antidepressants for smoking cessation / J.R. Hughes, L.F. Stead, J. Hartmann-Boyce [et al.] Cochrane Database of Systematic Reviews. — 2014. — Issue 1. — Art. № CD000031. DOI: 10.1002/14651858.CD000031.pub4.
  60. Jorenby, D.E. Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained release bupropion for smoking cessation: a randomized controlled trial / D.E. Jorenby, J.T. Hays, N.A. Rigotti [et al.] // J. Am. Med. Assoc. — 2006. — Vol. 296. — P.56—63.
  61. Kośmider, L. Electronic cigarette — a safe substitute for tobacco cigarette or a new threat? / L. Kośmider, J. Knysak, M.Ł. Goniewicz [et al.] // Przegl. Lek. — 2012. — Vol. 69(10). — P.1084—1089.
  62. Lancaster, T. Individual behavioral counselling for smoking cessation / T. Lancaster, L.F. Stead // Cochrane Database Syst. Rev. — 2005. — Vol. 2. — CD001292.
  63. Le Houezec, J. Smoking reduction and temporary abstinence: new approaches for smoking cessation / J. Le Houezec, U. Säwe // J. Mal. Vasc. — 2003. — Vol. 28(5). — P.293—300.
  64. McCarthy, D.E. Psychological mediators of bupropion sustained-release treatment for smoking cessation / D.E. McCarthy, T.M. Piasecki, D.L. Lawrence [et al.] // Addiction. — 2008. — Vol. 103. — P.1521—1533.
  65. McNeill, A. Reducing harm from tobacco use / A. McNeill, M.R. Munafo // J. Psychopharmacol. — 2013. — Vol. 27.
  66. McRobbie, H. Electronic cigarettes for smoking cessation and reduction / H. McRobbie, C. Bullen, J. Hartmann-Boyce [et al.] // Cochrane Database of Systematic Reviews. — 2014. — Issue 12. — Art. № CD010216.
  67. Morgan, C.J.A. Harms and benefits associated with psychoactive drugs: findings of an international survey of active drug users / C.J.A. Morgan, L.A. Noronha, M. Muetzelfeld [et al.] // J. Psychopharmacol. — 2013. — Vol. 27(6). — P.497—506.
  68. Nutt, D. Drug harms in the UK: a multicriteria decision analysis / D. Nutt, L.A. King, L.D. Philips // Lancet. — 2010. — Vol. 376. — P.1558—1565.
  69. Orr, K.K. Efficacy of electronic cigarettes for smoking cessation / K.K. Orr, N.J. Asal // Ann. Pharmacother. — 2014. — Vol. 48(11). — P.1502—1506.
  70. Owen, P. Should abstinence be the goal for alcohol treatment? / P. Owen, G.A. Marlatt // American Journal on Addictions. — 2001. — Vol. 10(4). — P.289—295.
  71. Pearson, J.L. E-Cigarettes and Smoking Cessation: Insights and Cautions From a Secondary Analysis of Data From a Study of Online Treatment-Seeking Smokers / J.L. Pearson, C.A. Stanton, S. Cha [et al.] // Nicotine Tob. Res. — 2014. — Vol. 26. — P.269.
  72. Pearson, J.L. Е-Cigarette awareness, use, and harm perceptions in US adults / J.L. Pearson, A. Richardson, R.S. Niaura [et al.] // Am. J. Public. Health. — 2012. — Vol. 102. — P.1758—1766.
  73. Peralta, A.R. Safety and efficacy of electronic cigarettes: a review / A.R. Peralta, V.P. Guntur // Mo Med. — 2014. — Vol. 111(3). — P.238—244.
  74. Perkins, K.A. Cognitive-Behavioral Therapy for Smoking Cessation: A Practical Guidebook to the Most Effective Treatments / K.A. Perkins, C.A. Conklin, M.D. Levine. — Routledge; New York, 2008.
  75. Piper, M.E. A randomized placebo-controlled clinical trial of 5 smoking cessation pharmacotherapies / M.E. Piper, S.S. Smith, T.R. Schlam [et al.] // Arch. Gen. Psychiatry. — 2009. — Vol. 66. — P.1253—1262.
  76. Pisinger, Ch. A systematic review of health effects of electronic cigarettes / Ch. Pisinger, M. Dossing // Preventive Medicine. — 2014. — Vol. 69. — P.248—260.
  77. Polosa, R. Effect of an electronic nicotine delivery device (e-Cigarette) on smoking reduction and cessation: a prospective 6-month pilot study / R. Polosa, P. Caponnetto, J.B. Morjaria [et al.] // BMC Public Health. — 2011. — Vol. 11. — P.786.
  78. Polosa, R. Effect of smoking abstinence and reduction in asthmatic smokers switching to electronic cigarettes: evidence for harm reversal / R. Polosa, J. Morjaria, P. Caponnetto [et al.] // Int. J. Environ Res. Public. Health. — 2014. — Vol. 11(5). — P.4965—4977.
  79. Polosa, R. Effectiveness and tolerability of electronic cigarette in real-life: a 24-month prospective observational study / R. Polosa, J.B. Morjaria, P. Caponnetto [et al.] // Intern. Emerg. Med. — 2014. — Vol. 9(5). — P.537—456.
  80. Popova, L. Alternative tobacco product use and smoking cessation: a national study / L. Popova, P.M. Ling // Am. J. Public. Health. — 2013. — Vol. 103. — P.923—930.
  81. Position Statement on Electronic Cigarettes [ECs] or Electronic Nicotine Delivery Systems [ENDS], International Union Against Tuberculosis and Lung Disease, 44th Union World Conference on Lung Health. — Paris, 2013.
  82. Rahman, M.A. Electronic Cigarettes Are Effective for Smoking Cessation: Evidence From a Systematic Review and Meta-analysis / M.A. Rahman, N.R. Hann, A.M. Wilson [et al.] // Circulation. — 2014. — Vol. 130. — A14945.
  83. Rodu, B. The scientific foundation for tobacco harm reduction, 2006—2011 / B. Rodu // Harm. Reduct. J. — 2011. — Vol. 8.
  84. Rodu, B. Tobacco harm reduction: an alternative cessation strategy for inveterate smokers / B. Rodu, W.T. Godshall // Harm reduction journal. — 2006. — Vol. 3. — P.37.
  85. Shahab, L. Electronic cigarettes are at least as effective as nicotine patches for smoking cessation / L. Shahab, M. Goniewicz // Evid. Based Med. — 2014. — Vol. 19(4). — P.133.
  86. Stead, L.F. Combined pharmacotherapy and behavioural interventions for smoking cessation. Editorial Group / L.F. Stead, T. Lancaster // Cochrane Tobacco Addiction Group. Published Online: 17 OCT 2012. Assessed as up-to-date: 4 SEP 2012. DOI: 10.1002/14651858.CD008286.pub2.
  87. Stead, L.F. Interventions to reduce harm from continued tobacco use / L.F. Stead, T. Lancaster // Cochrane Database Syst Rev. 2007 Jul 18;(3):CD005231.
  88. Stead, L.F. Nicotine replacement therapy for smoking cessation / L.F. Stead, R. Perera, C. Bullen [et al.] // Cochrane Database of Systematic Reviews. — 2012. — Issue 11. — Art. № CD000146. DOI: 10.1002/14651858.CD000146.pub4.
  89. Steinberg, M.B. E-Сigarette versus nicotine inhaler: comparing the perceptions and experiences of inhaled nicotine devices / M.B. Steinberg, M.H. Zimmermann, C.D. Delnevo [et al.] // Journal of General Internal Medicine. — 2014. — Vol. 29(11). — P.1444.
  90. Suter, M.A. Is There Evidence for Potential Harm of Electronic Cigarette Use in Pregnancy? / M.A. Suter, J. Mastrobattista, M. Sachs [et al.] // Birth Defects Res. A. Clin. Mol. Teratol. — 2014.
  91. The health consequences of smoking — 50 years of progress: a report of the Surgeon General. Atlanta (GA): US Department of Health and Human Services. — 2014.
  92. UNODC, WHO. Principles of drug dependence treatment. — Vienna: UNODC, 2008. — URL: http://www.who.int/tobacco/global_interaction/tobreg/9789241209458.pdf
  93. Van Amsterdam, J. Reduced-risk drinking as a viable treatment goal in problematic alcohol use and alcohol dependence / J. van Amsterdam, W. van den Brink // Journal of Psychopharmacology. — 2013. — URL: http://jop.sagepub.com/content/early/2013/07/02/0269881113495320
  94. Vansickel, A.R. A clinical laboratory model for evalua-ting the acute effects of electronic cigarettes: nicotine delivery profile and cardiovascular and subjective effects / A.R. Vansickel, C.O. Cobb, M.F. Weaver [et al.] // Cancer Epidemiol. Biomarkers Prev. — 2010. — Vol. 19. — P.1945—1953.
  95. Vickerman, K.A. Use of electronic cigarettes among state tobacco cessation quitline callers / K.A. Vickerman, K.M. Carpenter, T. Altman [et al.] // Nicotine Tob. Res. — 2013. — Vol. 15. — P.1787—1791.
  96. Vijayaraghavan, M. Interest in Smoking Cessation Related to a Smoke-Free Policy Among Homeless Adults / M. Vijayaraghavan, J.P. Pierce // J. Community Health. — 2015.
  97. Wang, D. «Cut down to quit» with nicotine repla- cement therapies in smoking cessation: a systematic review of effectiveness and economic analysis / D. Wang, M. Connock, P. Barton [et al.] // Health Technol Assess. — 2008. — Vol. 12(2). — P.1—135.
  98. WHO: guidelines for the psychosocially assisted pharmacological treatment of opioid dependence. — Geneva, 2009. — 123 p.
  99. World Health Organization. Waterpipe Tobacco Smoking: Health Effects, Research Needs and Recommended Actions by Regulators. — Geneva, Switzerland; World Health Organization, 2005.

 

ORGANIZATION OF HEALTHCARE

PDF downloadClinical and statistical analysis of morbidity with temporary disability of the economically active population of Kazan city

NuriKhan N. Shamsiyarov, C.Med.Sci., Honored Doctor of the Republic of Tatarstan, Deputy Director of the organizational and methodical work of ICC, tel. 8-927-442-78-70, e-mail: kybm@mail.ru

Afgat N. Galiullin, D.Med.Sci., Professor of Department of health management of SBEI HPE «Kazan State Medical University», tel. 8-987-296-87-64, e-mail: kybm@mail.ru

Abstract. Aim. To analyze morbidity with temporary disability (MTD) by the clinical and statistical analysis of economically active population of Kazan city. To perform the analysis of MTD according to a form 16BH. Material and methods. We studied 1011 variables on 6 indicators for this purpose in 1995—2011 years. Results. MTD coefficient was decreased from 861,1 in days (on 100 cases of the working population) in 1995 to 495,0 in 2011. Thus the morbidity coefficient in cases for this period decreased on 8,1 case on 100 cases of the working population. We demonstrated structure of MTD. In this structure, in the prevailing diseases forming the MTD high level were respiratory diseases, traumas and poisoning, bone and muscular system diseases. Predicting of morbidity with temporary disability of the population of economically active age from 2012 to 2016 is carried out. Conclusion. The received results of Kazan city are yielded in comparison with coefficient of MTD of the Republic of Tatarstan.

Key words: MTD, morbidity, cases, days of morbidity, the working population.

 

References

  1. Amirov, N.H. Trud i zdorov'e rukovoditelei [Safety and health managers] / N.H Amirov. — M.: GEOTARMed, 2002. — 134 s.
  2. Bant'eva, M.N. Vozrastnye aspekty zabolevaemosti vzroslogo naseleniya po obraschaemosti v ambulatorno-poliklinicheskie uchrezhdeniya [Age aspects of morbidity in the adult population in the uptake Outpatient clinics] / M.N. Bant'eva, N.S. Prilipko // Social'nye aspekty zdorov'ya [Social aspects of health]. — 2013. — № 4. — S.32.
  3. Sistemnyi analiz razvitiya mediko-demograficheskih processov v megapolise v period social'no-ekonomicheskih reform: monografiya [System analysis of medical and demographic processes in the metropolis during the period of social and economic reforms: a monograph] / A.N. Galiullin, N.N. Shamsiyarov, A.V. Glushakov [i dr]. — Kazan': Medicina, 2013 — 122 s.
  4. Nizamov, I.G. Zabolevaemost' s vremennoi utratoi trudosposobnosti k optimizacii upravleniya ohranoi zdorov'ya trudovyh kollektivov [The incidence of temporary disability to optimize the management of health labor collectives] / I.G. Nizamov. — Kazan': Medicina, 1993. — 144 s.
  5. Son, I.M. Sovremennye osobennosti zabolevaemosti vzroslogo naseleniya [Modern features of the adult population morbidity] / I.M. Son, S.A. Leonov, E.V. Ogryzko // Zdravoohranenie Rossiiskoi Federacii [Health of the Russian Federation]. — 2010. — № 1. — S.3—6.
  6. Starovoitova, I.M. Medicinskaya ekspertiza: ekspertiza vremennoi netrudosposobnosti, mediko-social'naya, voenno-vrachebnaya [Medical Examination: The examination of temporary disability, medical and social, military and medical] / I.M. Starovoitova, K.A. Sarkisov, N.P. Potehin. — 2-e izd., dop i pererab. — M.: GEOTAR-Media, 2010. — 668 s.
  7. Belyaevskii, A.I. Sistema ocenki organizacii i kachestva ekspertizy vremennoi netrudosposobnosti na regional'nom urovne [The system of assessment of the organization and the quality of examination of temporary disability at the regional level]: metod. posobie / A.I. Belyaevskii, G.I. Chechenin. — Novokuzneck, 2004. — 36 s.
  8. Verhovodova, O.V. Posobie po vremennoi netrudo- sposobnosti i podhody k kontrolyu ih vyplat (obzor slozhivsheisya v Rossii i za rubezhom praktiki) ) [Temporary disability benefits and approaches to control their payments (review existing in Russia and abroad practice)] / O.V. Verhovodova // Voprosy ekspertizy i kachestva medicinskoi pomoschi [Questions expertise and quality of care]. — 2006. — № 6. — S.46—57.
  9. Starodubov, V.I. Upravlyaemye faktory v profilaktike zabolevanij [Managed factors in disease prevention] / V.I. Starodubov, N.P. Soboleva, A.N. Lukashev. — M., 2003. — 175 s.

HELP FOR PRACTITIONER

PDF downloadTreatment of allergic rhinitis in women during pregnancy

Alla A. Vasiljeva, C.Med.Sci., associate professor of Department of clinical immunology and allergology of SBEI HPE «Kazan State Medical University», Kazan, Russia

Rezeda F. Khakimova, D.Med.Sci., Professor of Department of clinical immunology and allergology of SBei HPe «Kazan State Medical university», Kazan, russia, e-mail: khakimova@yandex.ru

Abstract. Aim. In this manuscript we show contemporary data on the diagnosis and treatment of allergic rhinitis in women during pregnancy. Material and methods. Pregnant women suffering from allergic rhinitis. The authors describe the choice of medications based on the evidence-based medicine, as well as also according to the toxicity of these medications to a pregnant woman and her future child. Results. Given that the organism of a pregnant woman undergoes specific physiological changes, many pathological conditions in this group of population present and run differently. It is known that allergic rhinitis in pregnants has more complicated course, оftenly, accompanying asthma gets worse. During allergic rhinitis in pregnancy it is important to do elimantion actions, as well as to use intranasal irrigation-elimination and barrier medications. Conclusion. Intranasal corticosteroids are the most effective drugs for basis therapy of allergic rhinitis in pregnant. Among those is Budesonide, that belongs to category B according to FDA.

Key words: allergic rhinitis, pregnancy, base therapy, symptomatic therapy.

 

References

  1. Allergologiya i immunologiya: nacional'noe rukovodstvo [Allergy and immunology: the national guide] / pod red. R.M. Haitova, N.I. Il'inoi. — M.: GEOTAR-Media, 2009. — 656 s.
  2. Allergologiya. Federal'nye klinicheskie rekomendacii [Allergology. Federal guidelines] / pod red. akad. RAN R.M. Haitova, prof. N.I. Il'ina. — M.: Farmarus Print Media, 2014. — 214 s.
  3. Belaya kniga WAO po allergii 2011—2012 [WAO White Book on Allergy 2011-2012]: rezyume / pod red. R.I. Sepiashvili, T.A. Slavyanskoi. — M.: Medicina-Zdorov'e, 2011. — 12 s.
  4. Vasil'eva, A.A. Allergicheskii rinit [Allergic rhinitis] / A.A. Vasil'eva, R.F. Hakimova. — Kazan': KGMU, 2009. — 50 s.
  5. Voznesenskii, N.A. K voprosu o bezopasnosti ingalya-cionnyh i intranazal'nyh glyukokortikosteroidov [To the question about the safety of inhaled and intranasal glucocorticosteroides] / N.A. Voznesenskii // Atmosfera. Pul'monologiya i allergologiya [Atmosphere. Pulmonology and Allergology]. — 2005. — № 2. — S.50—54.
  6. Voznesenskii, N.A. Aktual'nye aspekty primeneniya intranazal'nyh glyukokortikosteroidov [Relevant aspects of the use of intranasal glucocorticosteroides] / N.A. Voznesenskii, D.P. Polyakov // Atmosfera. Pul'monologiya i allergologiya [Atmosphere. Pulmonology and Allergology]. — 2010. — № 1. — S.20—24.
  7. Effektivnost' i bezopasnost' nazal'nogo spreya «Nazaval» v profilaktike i lechenii persistiruyuschego allergicheskogo rinita [The efficacy and safety of nasal spray Nazaval in the prevention and treatment of persistent allergic rhinitis] / T.V. Zaharzhevskaya, I.V. Sidorenko, V.K. Treskunov [i dr.] // Rossiiskii allergologicheskii zhurnal [Russian Allergology Jornal]. — 2009. — № 5. — S.82—86.
  8. Kolhir, P.V. Dokazatel'naya allergologiya-immunologiya [Evidence-Allergology-Immunology] / P.V. Kolhir. — M.: Prakticheskaya medicina, 2010. — 528 s.
  9. Krechikov, V.A. Risk primeneniya lekarstvennyh prepa- ratov pri beremennosti: fokus na budesonide [The risk of drugs used during pregnancy: focus on budesonide] / V.A. Krechikov, S.N. Kozlov // Atmosfera. Pul'monologiya i allergologiya [Atmosphere. Pulmonology and Aller- gology]. — 2008. — № 3. — S.22—26.
  10. Kurbacheva, O.M. Lechenie allergicheskogo rinita: kogda, kak i zachem? [Treatment of allergic rhinitis: when, how and why?] / O.M. Kurbacheva, N.I. Il'ina // Rossiiskii allergologicheskii zhurnal [Russian Allergology Jornal]. — 2006. — № 2. — S.66—75.
  11. Kurbacheva, O.M. Allergicheskii rinit i beremennost': vozmozhnosti sovremennoi terapii [Allergic rhinitis and pregnancy: the possibilities of modern therapy] / O.M. Kurbacheva, S.M. Shvec // Akusherstvo i ginekologiya [Obstetrics and gynecology]. — 2013. — № 2. — S.74—79.
  12. Lopatin, A.S. Diagnostika i lechenie rinita i rinosinusita u beremennyh [Diagnosis and treatment of rhinitis and rhinosinusitis in pregnant] / A.S. Lopatin // Rossiiskii allergologicheskii zhurnal [Russian Allergology Jornal]. — 2006. — № 1. — S.6—12.
  13. Luss, L.V. Allergiya i beremennost' [Allergy and pregnancy]/ L.V. Luss // Doktor ru [Doctor.ru]. — 2011. — № 3(62). — S.36—43.
  14. Nacional'naya programma «Bronhial'naya astma u detei. Strategiya lecheniya i profilaktika» [The national programme of Bronchial asthma in children. The strategy of treatment and prevention]. — 4-e izd., pererab. i dop. — M.: Original-maket, 2012. — 184 s.
  15. Ushkalova, E.A. Problemy bezopasnosti lekarstven- nyh sredstv vo vremya beremennosti [The national programme of Bronchial asthma in children. The stra- tegy of treatment and prevention] / E.A. Ushkalova // Trudnyi pacient [The Difficult patient]. — 2005. — № 2. — URL: http://www.t-pacient.ru/archive/n2-2005/n2- 2005l .html
  16. Allergic rhinitis and its impact on asthma guidelines. — 2010. — Vol. 9/8. — P.1—153. — URL: http://www.whiar.org/docs/ARIAReport_2010.pdf
  17. American College of Obstetricians and Gynecologists (ACOG) and American College of Allergy, Asthma and Immunology (ACAAI) // Ann. Allergy Asthma Immunol. — 2000. — Vol. 84. — P.475—480.
  18. Ellegard, E.K. Fluticasone propionate aqueous nasal spray in pregnancy rhinitis / E.K. Ellegard, M. Hellgren, N.G. Karlsson // Clin. Otolaryngol. — 2001. — Vol. 26. — № 5. — P.394—400.
  19. Emberlin, J.C. Double blind placebo controlled cross over trial of inert cellulose powder, by nasal provocation with grass pollen to assess efficacy of the product in controlling symptoms of hay ferer in adults / J.C. Emberlin, R.A. Lewis // Curr. Med. Res. Opin. — 2006. — Vol. 22, № 2. — P.275—285.
  20. FDA Pregnancy Labeling Task Force. — URL: http: //www.fda.gov/cder/handbook/categc.htm
  21. Gluck, P.A. A review of pregnancy outcomes after exposure to orally inhaled or intranasal budesonide / P.A. Gluck, J.C. Gluck // Curr. Med. Res. Opin. — 2005. — Vol. 21. — P.1075—1084.
  22. Incaudo, G.A. Diagnosis and treatment of allergic rhinitis and sinusitis during pregnancy and lactation / G.A. Incaudo // Clin. Rev. Allergy Immunol. — 2004. — Vol. 27(2). — P.159—178.
  23. Josling, P. Use of cellulose powder for the treatment of seasonal allergic rhinitis / P. Josling, S. Steadman // Adv. Ther. — 2003. — Vol. 20, № 4. — P.213—219.
  24. Keles, N. Treatment of allergic rhinitis during pregnancy / N. Keles // Am. J. Rhinol. — 2004. — Vol. 18(1). — P.23—28.
  25. Norjavaara, E. Normal pregnancy outcomes in a population-based study including 2,968 pregnant women exposed to budesonide / E. Norjavaara, M.G. de Verdier // J. Allergy Clin. Immunol. — 2003. — Vol. 111, № 4. — P.736—742.
  26. Osur, S.L. The management of asthma and rhinitis during pregnancy / S.L. Osur // J. Womens Health. — 2005. — Vol. 14(3). — P.263—276.
  27. Schatz, M. Changes in asthma severity during pregnancy correlate with rhinitis changes / M. Schatz // Allergy Asthma Immunol. — 2002. — Vol. 89. — P.463—466.
  28. Sur, D.K. Treatment of Allergic Rhinitis / D.K. Sur, S. Scandale //Am. Fam. Physician. — 2010. — № 81(12). — P.1440—1446.

 

CLINICAL CASE

PDF downloadFree wall myocardium rupture and thrombolytic therapy. Clinical observation

Natalya A. Kosheleva, D.Med.Sci., associate professor of Depatment of hospital therapy of SBEI HPE «Saratov State Medical university n.a. V.i. razumovsky», Head of office of urgent cardiology of Saratov regional clinical Hospital, Saratov, Russia, e-mail: kosheleva2009@yandex.ru

Dmitry V. Krasikov, internship doctor of Department of hospital therapy general medicine faculty of SBEI HPE «Saratov State Medical university n.a. V.i. razumovskiy», Saratov, russia, e-mail: krasikovmd@gmail.com

Igor A. Morozov, C.Med.Sci., Deputy chief physician on the Regional vascular center of Saratov Regional Clinical Hospital, Saratov, Russia, e-mail: igormorozov@mac.com

Andrey P. Rebrov, D.Med.Sci., professor, Head of Depatment of hospital therapy of SBEI HPE «Saratov State Medical university n.a. V.i. razumovsky», Saratov, russia, e-mail: andreyrebrov@yandex.ru

Abstract. Aim — to show an effective option of thrombolysis in myocardial reinfarction, complicated by late rupture of the anterior wall of the left ventricle. Material and methods. Clinical observation. Results and discussion. Reperfusion strategy prevented the development of early complications of acute myocardial infarction, but showed its two-faced effect. The described pathogenetic expansion mechanism of the myocardial necrosis zone explains the connection of thrombolytic therapy with the subsequent development of cardiac rupture. Conclusions. This clinical observation shows that thrombolytic therapy, being the main focus in the treatment of patients with myocardial infarction and ST-segment elevation, may increase the number of cardiac ruptures. The predictor of the impending cardiac rupture is the appearance of idioventricular rhythm. If over the next 1,5—2,0 hours the primary PCI is possible, balloon angioplasty and stenting of coronary arteries are preferable.

Key words: myocardial infarction, cardiac ruptures, thrombolytic therapy.

 

References

  1. Gafarov, V.V.  Infarkt miokarda (prognozirovanie ishodov na osnove programmy VOZ «Registr ostrogo infarkta miokarda», MONIKA) [Myocardial infarction (predicting outcomes based on the WHO program «Register of acute myocardial infarction», MONICA)] / V.V. Gafarov, M.Yu. Blaginina // Kardiologiya [Cardiology]. — 2005. — № 9. — S.80—81.
  2. Gorohovskii, B.I. Anevrizma i razryvy serdca [Aneurysm and heart failure] / B.I. Gorohovskii. — M.: MIA, 2001. — 1075 s.
  3. Gordeev, I.G. Reperfuziya u bol'nyh ostrym infarktom miokarda [Reperfusion in patients with acute myocardial infarction] / I.G. Gordeev, I.V. Il'enko, L.L. Klykov // Rossiiskii kardiologicheskii zhurnal [Russian Journal of Cardiology]. — 2006. — № 3. — S.71—75.
  4. Zeltyn'-Abramov, E.M. Naruzhnye razryvy serdca v ostrom periode infarkta miokarda: kliniko-instrumental'nye prediktory [Reperfusion in patients with acute myocardial infarction] / E.M. Zeltyn'-Abramov, A.E. Radzevich // Rossiiskii kardiologicheskii zhurnal [Russian Journal of Cardiology]. — 2010. — № 2. — S.10—13.
  5. Strozhakov, G.I. Razryvy miokarda [Myocardial rupture] / G.I. Strozhakov // Serdce. — 2007. — T. 6, № 4(36). — S.224—225.
  6. Yavelov, I.G. Problemy trombolizisa v nachale XXI veka [Problems thrombolysis at the beginning of the XXI century] / I.G. Yavelov // Serdce [Heart]. — 2007. — T. 6, № 4(36). — S.184—188.
  7. Becker, R.C. A composite view of cardiacrupture in United States National Registry of Myocardial Infarction / R.C. Becker, J. Gore, C. Labrew // J. Am. Coll. Cardiol. — 1996. — Vol. 27. — P.1321—1326.
  8. Ventricular Septal Rupture after Acute Myocardial Infarction / Y. Birnbaum, M.C. Fishbein, C. Blanche [et al.] // N. Engl. J. Med. — 2002. — Vol. 347, № 31. — P.1426—1432.
  9. Harvey, W. Complete works: translated by Willis R. / W. Harvey. — London: Sydenham Society, 1847. — 127 p.
  10. ESC guidelines for the management of acute myocardial 10. infarction in patients presenting with ST segment elevation / P.G. Steg, S.K. James, D. Atar [et al.] // Eur. Heart J. — 2012. — Vol. 33. — P.2569—2619.
  11. Keely, E.C.11. Free wall rupture in the elderly: deleterious effect of fibrinolytic therapy on the ageing heart / E.C. Keely, J.A. de Lemos // Eur. Heart J. — 2005. — Vol. 26. — P.1693—1694.