VSKM 2017 N 1

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REVIEWS

Progress and prospects for long-acting β2-agonists in the treatment of chronic obstructive pulmonary disease (COPD). Puxxedu E., Ora J., Calzetta L., Cazzola M. P. 7

Idiopathic pulmonary fibrosis: state of the problem. Vizel A.A., Vizel I.Yu., Amirov N.B. P. 15

P2Y-receptor agonists and antagonists in modern clinical practice. Kalinina O.S., Ziganshin A.U. P. 22

Laboratory diagnosis of mycobacteriosis. Lyamin A.V., Zhestkov A.V., Ismatullin D.D., Kovalyov A.M. P. 29

The relevance of preventative vaccination against pneumococcal infection in organized groups of military personnel. Shubin I.V. P. 36

ORGANIZATION OF HEALTHCARE

Topical issues of primary health care incidence. Berseneva E.A., Lalabekova M.V., Cherkasov S.N., Meshkov D.O. P. 43

ORIGINAL RESEARCH

Minimally invasive treatment of patients with massive multiple choledocholithiasis. Abramova A.G., Khorev A.N., Kozlov S.V., Pljuta A.V., Blagov D.A., Klokov V.A., Abramov G.S. P. 49

Expert quality assessment primary health care to the population with arterial hypertension. Аtsel E.А., Fomina A.V. P. 53

Evidence-based approach to biological agents in rheumatoid arthritis. Data from Moscow common arthritis registry. Zhilyaev E.V., Me-
zenova T.V., Lukina G.V., Koltsova E.N., Schmidt E.I. P. 65

Consumption of cardio-vascular medications purchased from private pharmacy chain by population? Tukhbatullina R.G., Nagaeva A.R. P. 71

The prevalence of metabolic syndrome components in metallurgical enterprise workers. Chigisova A.N., Ogarkov M.Yu. P. 79

HELP FOR PRACTITIONER

Guidelines on the medical care organization to the patients with hereditary atherogenic lipid disorders in the regions of Russia (joint project of the National society for the research on atherosclerosis and non-profit partnership «The National council of experts on rare diseases»). Sokolov A.A., Alexandrova O.Yu., Kashtalap V.V., Barbarash O.L., Yezhov M.V. P. 84

PRACTICAL EXPERIENCE

Problem of tuberculous detection in pulmonologist’s practice. Borodulina E.A., Povalyaeva L.V., Borodulina E.V., Vdoushkina E.S.,
Borodulin B.E. P. 89

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REVIEWS

UDC 616.24-036.12-085.234(048.8)

DOI: 10.20969/VSKM.2017.10(1).7-14

PDF downloadPROGRESS AND PROSPECTS FOR LONG-ACTING β2-AGONISTS IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

ERMANNO PUXXEDU, pneumologist, assistant of professor of the Department of respiratory medicine, the Department of systems medicine, University of Rome Tor Vergata, Rome, Italy, University Hospital Tor Vergata, Via Montpellier, 1, 00133, Rome, Italy, e-mail: ERMANNOPUX@libero.it

JOSUEL ORA, pneumologist, University hospital Tor Vergata, Via Montpellier, 1, 00133, Rome, Italy, e-mail: josuel78@gmail.com

LUIGINO CALZETTA, D. Med. Sci., research worker of the laboratory of respiratory clinical pharmacology of the Department of systems medicine, University of Rome Tor Vergata, Via Montpellier, 1, 00133, Rome, Italy, e-mail: luigino.calzetta@uniroma2.it

MARIO CAZZOLA, honorary professor of respiratory medicine, the Department of systems medicine, University of Rome Tor Vergata, Via Montpellier, 1, 00133, Rome, Italy, e-mail: mario.cazzola@uniroma2.it

Abstract. Aim. The treatment of chronic obstructive pulmonary disease (COPD) is generally based on the assumption of drug combinations in which β2-agonists are commonly included. Ultra-LABAs were developed to induce a greater adherence to the treatment as a result of the simplification of treatment with the reduction of the daily dose to be taken. Material and methods. We analyzed the current literature data on β2-adrenergic agonists. The potential positioning of ultra-LABAs in the treatment of COPD and their cardiovascular safety is discussed according to the new information on the topics. Results and discussion. The novel fixed-dose combinations of ultra-LABAs with LAMAs and/or ICSs are examined, as well as the novel ultra-LABAs under clinical development and the ultra-LABAs in preclinical development. Conclusion. The huge interest in developing new ultra-LABAs has apparently declined progressively in recent times. Nevertheless, ultra-LABAs are considered a fundamental component of the combinations with other classes of drugs (LAMAs and ICSs) that are central for treating COPD and now are administered on oncedaily basis.

Key words: Cardiovascular safety; combination therapy; COPD; monotherapy; ultra-LABAs.

For reference: Puxxedu E, Ora J, Calzetta L, Cazzola M. Progress and prospects for long-acting β2-agonists in the treatment of COPD. The Bulletin of Contemporary Clinical Medicine. 2017; 10 (1): 7—14. DOI: 10.20969/VSKM.2017.10(1).7-14.

References

1. Cazzola M, Matera MG, Lötvall J. Ultra long-acting β2-agonists in development for asthma and chronic obstructive pulmonary disease.Expert Opin Investig Drugs. 2005; 14: 775-783.
2. Matera MG, Cazzola M. Ultra-long-acting β2-adrenoceptor agonists: an emerging therapeutic option for asthma and COPD? Drugs. 2007; 67: 503-515.
3. Cazzola M, Matera MG. Emerging inhaled bronchodilators: an update. Eur Respir J. 2009; 34: 757-769.
4. Cazzola M, Calzetta L, Matera MG. Β2-adrenoceptor agonists: current and future direction. Br J Pharmacol. 2011; 163: 4-17.
5. Cazzola M, Rogliani P, Segreti A et al. An update on bronchodilators in Phase I and II clinical trials. Expert Opin Investig Drugs. 2012; 21: 1489-1501.
6. Cazzola M, Page CP, Rogliani P et al. β2-agonist therapy in lung disease. Am J Respir Crit Care Med. 2013;187:690-696.
7. Cazzola M, Calzetta L, Page CP et al. Pharmacological characterization of the interaction between aclidinium bromide and formoterol fumarate on human isolated bronchi. Eur J Pharmacol.2014;745:135-143.
8. Cazzola M, Calzetta L, Puxeddu E et al. Pharmacological characterisation of the interaction between glycopyrronium bromide and indacaterol fumarate in human isolated bronchi, small airways and bronchial epithelial cells. Respir Res. 2016; 17: 70.
9. Cazzola M, Calzetta L, Segreti A et al. Translational study searching for synergy between glycopyrronium and indacaterol. COPD. 2015; 12: 175-181.
10. Cazzola M, Calzetta L, Ora J et al.Searching for the synergistic effect between aclidinium and formoterol: From bench to bedside. Respir Med. 2015; 109: 1305-1311.
11. Calzetta L, Matera MG, Cazzola M. Pharmacological interaction between LABAs and LAMAs in the airways: optimizing synergy. Eur J Pharmacol. 2015; 761: 168-173.
12. Calzetta L, Rogliani P, Matera MG et al. A systematic review with meta-analysis of dual bronchodilation with LAMA/LABA for the treatment of stable COPD. Chest. 2016; 149: 1181-1196.
13. Cazzola M, Calzetta L, Page CP et al. Use of indacaterol for the treatment of COPD: a pharmacokinetic evaluation. Expert Opin Drug Metab Toxicol. 2014; 10: 129-137.
14. Matera MG, Rogliani P, Cazzola M. Indacaterol for the treatment of chronic obstructive pulmonary disease. Expert Opin Pharmacother .2015; 16: 107-115.
15. Matera MG, Rogliani P, Cazzola M. QVA149 (indacaterol/glycopyrronium) for the treatment of chronic obstructive pulmonary disease. Expert Opin Pharmacother. 2015; 16: 1079-1090
16. Matera MG, Ora J, Cazzola M. Differential pharmacology and clinical utility of long-acting bronchodilators in COPD  — focus on olodaterol. Ther Clin Risk Manag. 2015; 11: 1805-1811
17. Cazzola M, Rogliani P, Ora J et al. Olodaterol + tiotropium bromide for the treatment of chronic obstructive pulmonary disease. Expert Rev Clin Pharmacol. 2015; 8: 529-539.
18. Calzetta L, Ciaprini C, Puxeddu E et al. Olodaterol + tiotropium bromide for the treatment of COPD. Expert Rev Respir Med. 2016; 10: 379-386.
19. Matera MG, Capuano A, Cazzola M. Fluticasone furoate and vilanterol inhalation powder for the treatment of COPD. Expert Rev Respir Med. 2015; 9: 5-12.
20. Matera MG, Rogliani P, Rinaldi B et al. Umeclidinium bromide + vilanterol (ANORO) for the treatment of chronic obstructive pulmonary disease. Expert Rev Clin Pharmacol. 2015; 8: 35-41.
21. Calzetta L, Rinaldi B, Cazzola M et al. Pharmacodynamic and pharmacokinetic assessment of fluticasone furoate + vilanterol for the treatment of asthma. Expert Opin Drug Metab Toxicol. 2016; 12: 813-822.
22. Global Initiative for Chronic Obstructive Lung Disease. Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease (updated 2016). Available from: http://www.goldcopd.org/uploads/users/files/GOLD_Report%202016.pdf.
23. Kerstjens HA, Deslée G, Dahl R et al. The impact of treatment with indacaterol in patients with COPD: A post-hoc analysis according to GOLD 2011 categories A to D. Pulm Pharmacol Ther. 2015; 32: 101-108.
24. Mahler DA, Kerstjens HA, Donohue JF et al. Indacaterol vs tiotropium in COPD patients classified as GOLD A and B. Respir Med. 2015; 109: 1031-1309.
25. Ferguson G, Sachs P, Hamilton A et al. Efficacy of olodaterol once daily (QD) via Respimat in GOLD 2/3 COPD patients not receiving background therapy: pooled data from 48-week studies [abstract]. Chest. 2013; 144 (4_meetingabstracts): 727A.
26. Mahler DA, Buhl R, Lawrence D et al. Efficacy and safety of indacaterol and tiotropium in COPD patients according to  dyspnoea severity. Pulm Pharmacol Ther. 2013; 26: 348-355.
27. Rossi A, van der Molen T, del Olmo R et al. INSTEAD: a randomised switch trial of indacaterol versus salmeterol/fluticasone in moderate COPD. Eur Respir J. 2014; 44: 1548-1556.
28. Singh MP. Indacaterol therapy in moderate-to-severe chronic obstructive pulmonary disease: findings from a single-center primary care cohort. Int J Chron Obstruct Pulmon Dis. 2013; 8: 613-619.
29. Wedzicha JA, Buhl R, Lawrence D et al. Monotherapy with indacaterol once daily reduces the rate of exacerbations in patients with moderate-to-severe COPD: Post-hoc pooled analysis of 6 months data from three large phase III trials. Respir Med. 2015; 109: 105-111.
30. Decramer ML, Chapman KR, Dahl R et al. Once-daily indacaterol versus tiotropium for patients with severe chronic obstructive pulmonary disease (INVIGORATE): a randomised, blinded, parallel-group study. Lancet Respir Med. 2013; 1: 524-533.
31. Pascoe S, Locantore N, Dransfield MT et al. Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomised controlled trials. Lancet Respir Med. 2015; 3: 435-442.
32. Iqbal A, Barnes NC, Brooks J. Is blood eosinophil count a predictor of response to bronchodilators in chronic obstructive pulmonary disease? Results from post hoc subgroup analyses. Clin Drug Investig. 2015; 35: 685-688.
33. Price D, Asukai Y, Ananthapavan J et al. A UK-based cost-utility analysis of indacaterol, aonce-daily maintenance bronchodilator for patients with COPD, using real world evidence on resource use. Appl Health Econ Health Policy. 2013; 11: 259-274.
34. Cazzola M, Page CP, Calzetta L et al. Pharmacology and therapeutics of bronchodilators. Pharmacol Rev. 2012; 64: 450-504.
35. Cazzola M, Matera MG, Donner CF. Inhaled β2-adrenoceptor agonists: cardiovascular safety in patients with obstructive lung disease. Drugs. 2005; 65: 1595-1610.
36. Xia N, Wang H, Nie X. Inhaled long-acting β2-agonists do not increase fatal cardiovascular adverse events in COPD: A meta-analysis. PLoS One. 2015; 10: e0137904.
37. McGarvey L, Niewoehner D, Magder S et al. One-year safety of olodaterol once daily via Respimat® in patients with GOLD 2-4 chronic obstructive pulmonary disease: results of a pre-specified pooled analysis. COPD. 2015; 12: 484-493.
38. Rinaldi B, Donniacuo M, Sodano L et al. Effects of chronic treatment with the new ultra-long-acting β2-adrenoceptor agonist indacaterol alone or in combination with the β1-adrenoceptor blocker metoprolol on cardiac remodelling. Br J Pharmacol. 2015; 172: 3627-3637.
39. Matera MG, Calzetta L, Cazzola M. β-Adrenoceptor modulation in chronic obstructive pulmonary disease: present and future perspectives. Drugs. 2013; 73: 1653-1663.
40. Segreti A, Fiori E, Calzetta L et al. The effect of indacaterol during an acute exacerbation of COPD. Pulm Pharmacol Ther. 2013; 26: 630-634.
41. Santus P, Radovanovic D, Di Marco S et al. Effect of indacaterol on lung deflation improves cardiac performance in hyperinflated COPD patients: an interventional, randomized, double-blind clinical trial. Int J Chron Obstruct Pulmon Dis. 2015; 10: 1917-1923.
42. Wedzicha JA, Banerji D, Chapman KR et al. Indacaterol-glycopyrronium versus salmeterol-fluticasone for COPD. N Engl J Med. 2016; 374: 2222-2234.
43. Wessler I, Kirkpatrick CJ.Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans. Br J Pharmacol. 2008; 154: 1558-1571.
44. Cazzola M, Matera MG. Triple combinations in chronic obstructive pulmonary disease  — is three better than two? Expert Opin Pharmacother. 2014; 15: 2475-2478.
45. Siler TM, Kerwin E, Sousa AR et al. Efficacy and safety of umeclidinium added to fluticasone furoate/vilanterol in chronic obstructive pulmonary disease: Results of two randomized studies. Respir Med. 2015; 109: 1155-1163.
46. Pascoe SJ, Lipson DA, Locantore N et al. A phase III randomised controlled trial of single-dose triple therapy in COPD: the IMPACT protocol. Eur Respir J. 2016; 48: 320-330.
47. Aparici M, Gómez-Angelats M, Vilella D et al. Pharmacological characterization of abediterol, a novel inhaled β2-adrenoceptor agonist with long duration of action and a favorable safety profile in preclinical models. J Pharmacol Exp Ther. 2012; 342: 497–509.
48. Aparici M, Gavaldà A, Ramos I et al. In vitro and in vivo preclinical profile of abediterol (LAS100977), an inhaled long-acting β2-adrenoceptor agonist, compared with indacaterol, olodaterol and vilanterol. Eur J Pharmacol. 2016; 770: 61-69.
49. Miralpeix M, Letosa M, Aparici M et al. Abediterol, a novel long-acting β2 agonist, has a fast association rate and long residence time at human β2 receptors [abstract]. Eur Respir J. 2014; 44: P3328.
50. Singh D, Pujol H, Ribera A et al. A dose-ranging study of the bronchodilator effects of abediterol (LAS100977), a long-acting β2-adrenergic agonist, in asthma; a Phase II, randomized study. BMC Pulm Med. 2014; 14: 176.
51. Beier J, Pujol H, Seoane B et al. Abediterol, a novel long-acting β2-agonist: bronchodilation, safety, tolerability and pharmacokinetic results from a single-dose, dose-ranging, active-comparator study in patients with COPD. BMC Pulm Med. 2016; 16: 102.
52. Glossop PA, Lane CAL, Price DA et al. Inhalation by design: novel ultra-long-acting β2-adrenoreceptor agonists for inhaled once-daily treatment of asthma and chronic obstructive pulmonary disease that utilize a sulfonamide agonist headgroup. J Med Chem. 2010; 53: 6640-6652.
53. Li GL, Maclnyre F, Surujbally B et al. Pharmacokinetics of PF-00610355, a novel inhaled long-acting β2-adrenoceptor agonist[abstract]. Eur Respir J. 2009; 34: 777s-778s.
54. Ward J, Macintyre F, Jones I et al. Randomised double-blind, study to determine the efficacy and safety of a once-daily inhaled β2-adrenoceptor agonist, PF-00610355 in asthmatic patients [abstract]. Eur Respir J. 2009; 34: 778s-780s.55.
Nielsen JC, Hutmacher MM, Cleton A et al. Longitudinal FEV1 dose–response model for inhaled PF-00610355 and salmeterol in patients with chronic obstructive pulmonary disease. J Pharmacokinet Pharmacodyn. 2012; 39: 619-634.
56. Diderichsen PM, Cox E, Martin SW et al. Predicted heart rate effect of inhaled PF-00610355, a long acting β-adrenoceptor agonist, in volunteers and patients with chronic obstructive pulmonary disease. Br J Clin Pharmacol. 2013; 76: 752-762.
57. Stocks MJ, Alcaraz L, Bailey A et al. Discovery of AZD3199, An inhaled ultralong acting β2 receptor agonist with rapid onset of action. ACS Med Chem Lett. 2014; 5: 416-21.
58. Bjermer L, Kuna P, Jorup C et al. Clinical pharmacokinetics of AZD3199, an inhaled ultra-long-acting β2-adrenoreceptor agonist (uLABA). Drug Des Devel Ther. 2015; 9: 753-762.
59. Bjermer L, Rosenborg J, Bengtsson T et al. Comparison of the bronchodilator and systemic effects of AZD3199, an inhaled ultra-long-acting β2-adrenoceptor agonist, with formoterol in patients with asthma. Ther Adv Respir Dis. 2013; 7: 264-271.
60. Kuna P, Ivanov Y, Trofimov VI et al. Efficacy and safety of AZD3199 vs formoterol in COPD: a randomized, double-blind study. Respir Res. 2013; 14: 64.
61. Tricco AC, Strifler L, Veroniki AA et al. Comparative safety and effectiveness of long-acting inhaled agents for treating chronic obstructive pulmonary disease: a systematic review and network meta-analysis. BMJ Open. 2015; 5: e009183.
62. Jacobsen JR, Choi SK, Combs J et al. A multivalent approach to the discovery of long-acting β2-adrenoceptor agonists for the treatment of asthma and COPD. Bioorg Med Chem Lett. 2012; 22: 1213-1218.
63. Arnold N, Beattie D, Bradley M et al. The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1- hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-acting β2-adrenoceptor agonist. Bioorg Med Chem Lett. 2014; 24: 4341-4347.
64. Procopiou PA, Barrett VJ, Biggadike K et al. Discovery of a rapidly metabolized, long-acting β2 adrenergic receptor agonist with a short onset time incorporating a sulfone group suitable for once-daily dosing. J Med Chem. 2014; 57: 159-170.
65. Jacobsen JR, Aggen JB, Church TJ et al. Multivalent design of long-acting β2-adrenoceptor agonists incorporating biarylamines. Bioorg Med Chem Lett. 2014; 24: 2625-2630.
66. McKinnell RM, Klein U, Linsell MS et al. Discovery of TD-4306, a long-acting β2-agonist for the treatment of asthma and COPD. Bioorg Med Chem Lett. 2014; 24: 2871-2876.
67. Decramer ML, Chapman KR, Dahl R et al. Once-daily indacaterol versus tiotropium for patients with severe chronic obstructive pulmonary disease (INVIGORATE): a randomised, blinded, parallel-group study. Lancet Respir Med. 2013; 1: 524-533.
68. Vestbo J, Vogelmeier C, Small M et al. Understanding the GOLD 2011 Strategy as applied to a real-world COPD population. Respir Med. 2014; 108: 729-736.
69. Wurst KE, Punekar YS, Shukla A. Treatment evolution after COPD diagnosis in the UK primary care setting. PLoS One. 2014; 9: e105296.
70. Chowdhury BA, Pan G. The FDA and safe use of long-acting beta-agonists in the treatment of asthma. N Engl J Med. 2010; 362: 1169-1171.
71. Hartung DM, Middleton L, Markwardt S et al. Changes in long-acting β-agonist utilization after the FDA’s 2010 drug safety communication. Clin Ther. 2015; 37: 114-123.
72. Toy EL, Baulieu NU, McHale JL et al. Treatment of COPD: relationship between daily dosing frequency, adherence, resource use, and costs. Respir Med. 2011; 105 (3): 435–441.
73. Vestbo J, Anderson JA, Calverley PM et al. Adherence to inhaled therapy, mortality and hospital admission in COPD. Thorax. 2009; 64: 939-943
74. Ágh T, Inotai A, Mészáros Á. Factors associated with medication adherence in patients with chronic obstructive pulmonary disease. Respiration 2011; 82: 328-334.
75. Cazzola M, Rogliani P, Matera MG. Escalation and de-escalation of therapy in COPD: myths, realities and perspectives. Drugs. 2015; 75: 1575-1585.

 

UDC 616.24-004(048.8)

DOI: 10.20969/VSKM.2017.10(1).14-21

PDF downloadIDIOPATHIC PULMONARY FIBROSIS: STATE OF THE PROBLEM

VIZEL ALEXANDER A., D. Med. Sci., professor, Head of the Department of phthisiopulmonology of Kazan State Medical University, chief independent pulmonologist of the Ministry of Health of Republic of Tatarstan, Russia, 420012, Kazan, Butlerov str., 49, e-mail: lordara@inbox.ru

VIZEL IRINA YU., C. Med. Sci., assistant of professor of the Department of phthisiopulmonology of Kazan State Medical University, professor of Russian Academy of Natural History, Russia, 420012, Kazan, Butlerov str., 49, e-mail: tatpulmo@mail.ru

AMIROV NAIL B., D. Med. Sci., professor of the Department of general medical practice of Kazan State Medical University, аcademician of Russian Academy of Natural History, Russia, 420012, Kazan, Butlerov str., 49, e-mail: namirov@mail.ru

Abstract. Aim. Content analysis and review of the works devoted to the modern understanding of idiopathic pulmonary fibrosis and its treatment. Material and methods. Publications of national and foreign authors were reviewed. Results and discussion. Idiopathic pulmonary fibrosis is a special form of chronic progressive fibrosing interstitial pneumonia of unknown etiology that occurs predominantly in older people. It only affects lungs and it is associated with histological and/or X-ray pattern of usual interstitial pneumonia. Prediction flow of idiopathic pulmonary fibrosis is worse than in some cancers. Diagnosis of idiopathic pulmonary fibrosis is based on the result of the multidisciplinary conclusion of pulmonologist, radiologist and pathologist. The leading diagnostic criterion is a set of X-ray computer tomography data of high resolution, which are the changes in basal predominance or cortical parts of the lungs; diffuse reticular changes; «honeycomb lung» with traction bronchiectasis or without them and the absence of any signs that are contrary to this pathology. Functional assessment of the patients is based on the measurement of vital and diffusion capacity of the lungs. Surgical methods for the preparation of tissue samples are only recommended for non-compliance of the X-ray signs of idiopathic pulmonary fibrosis or if other diseases are suspected. Application of nintedaniba, pirfenidoza, sildenafil and N-acetylcysteine is being discussed in terms of existing medical methods. Conclusion. The new understanding of idiopathic pulmonary fibrosis is achieved at present. The new mechanisms of pathogenesis largely associated with the repeated damage and repair of the anomalous than inflammation were established. In the last decades there were clinical studies that gave hope for emergence of the medications that slow down lung fibrosis development and reduce mortality from this disease.

Key words: idiopathic pulmonary fibrosis, pathogenesis, diagnosis, treatment.

For reference: Vizel AA, Vizel IYu, Amirov NB. Idiopathic pulmonary fibrosis: state of the problem. The Bulletin of Contemporary Clinical Medicine. 2017; 10 (1): 14—21. DOI: 10.20969/VSKM.2017.10(1).14-21.

References

1. Troy L, Glaspole I, Goh N et al. Prevalence and prognosis of unclassifiable interstitial lung disease. Eur Respir J. 2014; 43 (5): 1529–1530.
2. Skolnik K, Ryerson CJ. Unclassifiable interstitial lung disease: a review. Respirology. 2016; 21 (1): 51–56.
3. ERS. Respiratory Epidemiology: monograph. 2014; 65: DOI: 10.1183/2312508X.erm6514
4. Liebow A. Definition and classification of interstitial pneumonias in human pathology. Prog Respir Res. 1975; 8: 1–32.
5. Katzenstein AL, Myers JL. Idiopathic pulmonary fibrosis: clinical relevance of pathologic classification. Am J Respir Crit Care Med. 1998; 157 (4 Pt 1): 1301–1315.
6. American Thoracic Society; European Respiratory Society: American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med. 2002; 165 (2): 277–304.
7. l’kovich MM, Novikova LN, Dvorakovskaja IV. Idiopaticheskij fibrozirujushhij al’veolit: protivorechija v sovremennyh predstavlenijah [Idiopathic fibrosing alveolitis: contradictions in the current understanding]. Bolezni organov dyhanija [Diseases of the respiratory system]. 2009; 1: 3.
8. Popova EN. Idiopaticheskij fibrozirujushhij al’veolit: diagnostika i lechenie [Idiopathic fibrosing alveolitis: diagnosis and treatment]. Vrach [Doctor]. 2005; 5: 24-27.
9. Sulbaeva KR, Hamitov RF, Kudrjavceva JeZ. Analiz gospital’nogo techenija idiopaticheskogo fibrozirujushhego al’veolita [Analysis of hospital flow of idiopathic fibrosing alveolitis]. Vestnik Sovremennoj Klinicheskoj Mediciny [The Bulletin of Contemporary Clinical Medicine]. 2009; 2 (3): 34-36.
10. Hamman L, Rich AR. Fulminating diffuse interstitial fibrosis of the lungs. Trans Am Clin Climatol Assoc. 1935; 51: 154-163.
11. Il’kovich M.M. Idiopaticheskij fibrozirujushhij al’veolit  — v knige: Disseminirovannye processy v ljogkih, pod redakciey NV Putova [Idiopathic fibrosing alveolitis  — in the book: Disseminated processes in the lungs, ed NV Putova. Moskva [Moscow]: Medicina [Medicine]. 1984: 83-105.
12. Ryu JH, Moua T, Azadeh N, Baqir M, Yi ES. Current concepts and dilemmas in idiopathic interstitial pneumonias. F1000Res. 2016; 5: 2661.
13. Chuchalin AG, Avdeev SN, Avdeev SN, Belevskij AS, Demura SA, Il’kovich MM, Kogan EA, Samsonova MV, Speranskaja AA, Tjurin IE, Chernjaev AL, Chernjak BA, Chernjak AV, Shmeljov EI. Diagnostika i lechenie idiopaticheskogo ljogochnogo fibroza. Federal’nye klinicheskie rekomendacii [Diagnosis and treatment of idiopathic pulmonary fibrosis. Federal clinical guidelines]. Pul’monologija [Pulmonology]. 2016; 26 (4): 399-420.
14. Shmeljov EI. Idiopaticheskij fibrozirujushhij al’veolit [Idiopathic fibrosing alveolitis]. Atmosfera; Pul’monologija i allergologija [Atmosphere: pulmonology and allergology]. 2004; 1: 3-8.
15. Avdeev SN. Razlichnye varianty techenija idiopaticheskogo ljogochnogo fibroza: fenotipy i komorbidnye sostojanija [Different variants of idiopathic pulmonary fibrosis: phenotypes and comorbid conditions]. Prakticheskaja pul’monologija [Practical pulmonology]. 2016; 2: 37-46.
16. Tjurin IE. Rentgenologicheskoe issledovanie bol’nyh idiopaticheskim ljogochnym fibrozom. Metodicheskie rekomendacii dlja vrachej rentgenologov, pul’monologov, terapevtov, vrachej obshhej praktiki [X-rays of patients with idiopathic pulmonary fibrosis. Guidelines for radiologists, pulmonologists, internists, general practitioners]. Moskva [Moscow]: RMAPO. 2016; 32 p.
17. Raghu G, Collard HR, Egan JJ et al. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med. 2011; 183 (6): 788–824.
18. Casan Clarà P, Martínez González C, Ancochea J. Pruebas de función pulmonar en la fibrosis pulmonar idiopática: más allá de la espirometría? Arch Bronconeumol. 2016; 52 (9): 457–458.
19. Kreider ME, Hansen-Flaschen J, Ahmad NN et al. Complications of video-assisted thoracoscopic lung biopsy in patients with interstitial lung disease. Ann Thorac Surg. 2007; 83 (3): 1140–1144.
20. Tomassetti S, Wells AU, Costabel U et al. Bronchoscopic lung cryobiopsy increases diagnostic confidence in the multidisciplinary diagnosis of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2016; 193 (7): 745–752.
21. Walsh SL, Wells AU, Desai SR et al. Multicentre evaluation of multidisciplinary team meeting agreement on diagnosis in diffuse parenchymal lung disease: a case-cohort study. Lancet Respir Med. 2016; 4 (7): 557–565.
22. Collard HR, Moore BB, Flaherty KR et al. Acute exacerbations of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2007; 176 (7): 636–643.
23. Fujimoto H, Kobayashi T, Azuma A. Idiopathic pulmonary fibrosis: treatment and prognosis. Clin Med Insights Circ Respir Pulm Med. 2016; 9 (Suppl 1): 179-185.
24. Rochwerg B, Neupane B, Zhang Y, Garcia CC, Raghu G, Richeldi L, Brozek J, Beyene J, Schünemann H. Treatment of idiopathic pulmonary fibrosis: a network meta-analysis. BMC Med. 2016; 14: 18.
25. Yu W, Guo F, Song X. Effects and mechanisms of pirfenidone, prednisone and acetylcysteine on pulmonary fibrosis in rat idiopathic pulmonary fibrosis models. Pharm Biol. 2017; 55 (1): 450-455.

 

UDC 615.273(048.8)

DOI: 10.20969/VSKM.2017.10(1).22-28

PDF downloadP2Y-RECEPTOR AGONISTS AND ANTAGONISTS IN MODERN CLINICAL PRACTICE

KALININA OLGA S., special pharmaceutical discipline teacher of Medical and Pharmaceutical College of Kazan State Medical  University, Russia, 420012, Kazan, Butlerov str., 49, tel. 8-950-318-23-23, e-mail: os_kalinina@bk.ru

ZIGANSHIN AYRAT U., D. Med. Sci., professor, Head of the Department of pharmacology of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. 8-987-297-88-64, e-mail: auziganshin@gmail.com

Abstract. Aim. To analyze the recent publications on the medications, which are P2Y-receptor agonists and antagonists in modern clinical practice. Material and methods. Current article is an analytical review of Russian and foreign literature. Results and discussion. P2 receptors are widely spread in different tissues and participate in a variety of physiological and pathological processes. A number of substances which are potential P2 receptor agonists or antagonists are synthesized and investigated. Some of them are introduced into clinical practice, which is an undoubted achievement of pharmacology. The article presents characteristics of the drugs affecting P2Y receptors as well as their advantages and disadvantages. Conclusion. Currently P2Y12-receptor antagonists are widely used in treatment of cardiovascular diseases. Research and development of new compounds, potential P2 receptors agonists and antagonists is being carried out. There is a high probability of occurrence and introduction of new drugs into clinical practice.

Key words: P2Y-receptor, antagonists, agonists, antiplatelet agents.

For reference: Kalinina OS, Ziganshin AU. P2Y-receptor agonists and antagonists in modern clinical practice. The Bulletin of Contemporary Clinical Medicine. 2017; 10 (1): 22—28. DOI: 10.20969/VSKM.2017.10(1).22-28.

References

1. McMurray J, Adamopoulos S, Anker S et al. Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Eur Heart J. 2012; 33 (14): 1787–1847.
2. Zetterberg F, Svensson P. State of affairs: Design and structure-activity relationships of reversible P2Y12 receptor antagonists. Bioorg Med Chem Lett. 2016; 26: 2739-2754.
3. Dash D. Current Status of Antiplatelet Therapy in Acute Coronary Syndrome. Cardiovascular & Hematological Agents in Medicinal Chemistry. 2015; 13: 40-49.
4. Hamm C., Bassand J, Zahger D. ESC Committee for Practice Guidelines. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-elevation of the European Society of Cardiology(ESC). Eur Heart J. 2011; 32: 2999-3054.
5. Laine M, Paganelli F, Bonello L. P2Y12-ADP receptor antagonists: Days of future and past. World J Cardiol. 2016; 8: 327–332.
6. Zhang Y, Zhang S, Ding Z. Role of P2Y12 Receptor in Thrombosis. Adv Exp Med Biol. 2016; 906: 307-324.
7. Gachet C. P2 receptors, platelet function and pharmacological implications. Thromb Haemost. 2008; 99: 466-472.
8. Mega J, Close S, Wiviott S et al. Cytochrome P–450 polymorphisms and response to Clopidogrel. N Engl J Med. 2009; DOI: 10.1056/NEJMoa0809171. Available at: http://www.nejm.org.
9. Bhatt DL, Flather MD, Hacke W et al. CHARISMA Investigators. Patients with prior myocardial infarction, stroke, or symptomatic peripheral arterial disease in the CHARISMA trial. J Am Coll Cardiol. 2007; 49: 1982–1988.
10. Mehta SR, Bassand JP, Chrolavicius S et al. Design and rationale of CURRENT–OASIS 7: a randomized, 2 x 2 factorial trial evaluating optimal dosing strategies for clopidogrel and aspirin in patients with ST and non–ST–elevation acute coronary syndromes managed with an early invasive strategy. Am Heart J. 2008; 156: 1080–1088.
11. Wang TH, Bhatt DL, Fox KA et al. CHARISMA Investigators. An analysis of mortality rates with dual–antiplatelet therapy in the primary prevention population of the CHARISMA trial. Eur Heart J. 2007; 28: 2200–2207.
12. Vandvic PO, Linkoff AM, Spenser FA et al. Primary and secondary prevention of cardiovascular disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012; 141: e637S.
13. Sabatine M, Cannon C, Braunwald E. CLARITY-TIMI 28 Investigators. Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-elevation. N Engl J Med. 2005; 352: 1179-1189.
14. Storozhakov TI, Tronina OA. Sovremennye aspekty primenenija preparata klopidogrel dlja lechenija i profilaktiki aterotromboza [Modern aspects of clopidogrel application for atherothrombosis treatment and prevention]. Atmosfera; Novosti kardiologii [Atmosphere; Cardiology news]. 2011; 1: 29-36.
15. Shilov AM. Sovremennye aspekty antiagregantnoj terapii v profilaktike trombozov (kak prichiny serdechno–sosudistyh oslozhnenij) v praktike vracha pervichnogo zvena [Modern aspects of antiplatelet therapy in the prevention of thrombosis (as a cause of cardiovascular complications) in the practice of primary care physicians]. RMZh [RMJ]. 2011; 26: 1068-1075.
16. Doğan A, Kahraman S, Çiftçi C. Effect of obesity and serum leptin level on clopidogrel resistance.Turk Kardiyol Dern Ars. 2016; 44: 548-553.
17. Sulimov VA, Moroz EV. Rezistentnost’ k antitrombocitarnym preparatam (aspirinu, klopidogrelu) u pacientov, podvergajushhihsja jelektivnomu stentirovaniju koronarnyh arterij [Resistance to antiplatelet drugs (aspirin, clopidogrel) in patients undergoing elective coronary stenting].Racional’naja farmakoterapija v kardiologii [Rational pharmacotherapy in cardiology]. 2012; 1: 23-30.
18. Serebruany V, Cherala G, Atar D et al. Association of platelet responsiveness with clopidogrel metabolism: Role of compliance in the assessment of «re-sistance». Am Heart J. 2009; 158: 925-932.
19. Bagrij AJe. Preparaty, blokirujushhie P2Y12-receptory trombocitov: dlja praktikujushhego vracha? [Drugs inhibiting platelet P2Y12-receptor: for the practitioner?]. Novosti mediciny i farmacii [Medicine and Pharmacy News]. 2011; 368: 31-38.
20. Hermosillo A, Spinler S. Aspirin, clopidogrel, and warfarin: is the combination appropriate and effective or inappropriate and too dangerous? Ann Pharmacother. 2008; 42: 790–805.
21. Manolis A, Tzeis S, Andrikopoulus G et al. Aspirin and clopidogrel: a sweeping combination in cardiology. Curr Med Chem Cardiovas Hematol Agents. 2005; 3: 203-219.
22. Qiu Z, Li N, Chen X et al. Pharmacokinetics of vicagrel, a promising analog of clopidogrel, in rats and beagle dogs. J Pharm Sci. 2013; 102: 741-749.
23. Shan J, Zhang B, Sun H et al. Overcoming clopidogrel resistance: discovery of vicagrel as a highly potent and orally bioavailable antiplatelet agent. J Med Chem. 2012; 55: 3342-3352.
24. Ziganshin AU. Novye antiagreganty  — blokatory trombocitarnyh R2-receptorov [New antiplatelet agents  — P2 platelet receptors antagonists]. Kazanskii Medicinskii Zhurnal [Kazan Medical Journal]. 2010; 1: 73-79.
25. Cannon CP, Harrington RA, James S et al. Comparison of ticagrelor with clopidogrel in patients with a planned invasive stategy for acute coronary syndromes (PLATO): a randomized double-blind study. Lancet. 2010; 375: 283-293.
26. Flierl U, Zauner F, Schäfer A. Efficacy of prasugrel administration immediately after percutaneous coronary intervention in ST-elevation myocardial infarction. Thromb Haemost. 2016; 117 (1): 96-102.
27. Gunarathne A, Hussain S, Gershlick A. Prasugrel hydrochloride for the treatment of acute coronary syndrome patients. Expert Rev Cardiovasc Ther. 2016; 14: 1215-1226.
28. Ichikawa S, Tsukahara K, Kimura K. Pharmacodynamic Assessment of Platelet Reactivity After a Loading Dose of Prasugrel or Clopidogrel in Patients With ST-Segment Elevation Myocardial Infarction. Circ J. 2016; 12: 2520-2527.
29. Olivier C, Diehl P, Schnabel K. Third generation P2Y12 antagonists inhibit platelet aggregation more effectively than clopidogrel in a myocardial infarction registry. Thromb Haemost. 2014; 111: 266-272.
30. Wiviotti S, Braunwald E, McCabe CH et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2007; 357: 2001–2015.
31. Olivier C, Schnabel K, Weber S. Platelet reactivity after administration of third generation P2Y12-antagonists does not depend on body weight in contrast to clopidogrel. J Thromb Thrombolysis. 2016; 42: 84-89.
32. Levine GN, Bates ER, Ting HH et al. 2011 ACCF/AHA/SCAI Guideline for percutaneous coronary intervention: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions. J Am Coll Cardiol. 2011; 58: 44–122.
33. Chong TT, Liu P, Wu W et al. Impact of novel P2Y12 receptor inhibitors on platelet reactivity in acute coronary syndrome patients undergoing percutaneous coronary intervention. Zhonghua Xin Xue Guan Bing Za Zhi. 2016; 2: 138-143.
34. Hajsadeghi S, Chitsazan M, Moghadami S. Prasugrel Results in Higher Decrease in High-Sensitivity C-Reactive Protein Level in Patients Undergoing Percutaneous Coronary Intervention Comparing to Clopidogrel. Clin Med Insights Cardiol. 2016; 10: 149–155.
35. Burjakina TN, Zatejshhikov DA. Mesto obratimyh ingibitorov receptorov R2Y12 pri ostrom koronarnom syndrome [The place of P2Y12 receptors reversible inhibitors in acute coronary syndrome]. Kardiologija [Cardiology]. 2012; 4: 45-53.
36. Sumarokov AB. Novye dezagregantnye preparaty: Chast’ 2 [New antiplatelet drugs: Part 2]. Racional’naja farmakoterapija v kardiologii [Rational Pharmacotherapy in Cardiology]. 2011; 7: 637-645.
37. Nechaeva GI, Drokina OV, Fisun NI. Sovremennaja antiagregantnaja terapija: mesto tikagrelora v klinicheskih rekomendacijah [Current antiplatelet therapy: the place of ticagrelor clinical guidelines]. Lechashhij vrach [The attending physician]. 2015; 3: 36-41.
38. Wallentin L, Becker RC, Budaj A et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2009; 361: 1045–1057.
39. Dalal J, Digrajkar A, Gandhi A. Oral antiplatelet therapy and platelet inhibition: An experience from a tertiary care center. Indian Heart J.2016; 68: 624-631.
40. Ahn Y, Lee J, Kim S. Identification of a New Morpholine Scaffold as a P2Y12 Receptor Antagonist. Molecules. 2016; 21: 1114.
41. Hamm C, Bassand J, Zahger D. ESC Committee for Practice Guidelines: ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-elevation of the European Society of Cardiology (ESC). Eur Heart J. 2011; 32: 2999-3054.
42. Würtz M, Grove E. Proton Pump Inhibitors in Cardiovascular Disease: Drug Interactions with Antiplatelet Drugs. Adv Exp Med Biol. 2016; 906: 325-350.
43. Johnson D, Chilton R, Liker H. Proton-pump inhibitors in patients requiring antiplatelet therapy: new FDA labeling. Postgrad Med. 2014; 126: 239-245.
44. Mitina TM, Jakovlev DS, Spasov AA. Antiagregantnaja i antitromboticheskaja aktivnosti novogo R2Y12-antagonista  — soedinenija Sbt-119 ex i in vivo [Antiplatelet and antithrombotic activity of the new P2Y12 antagonist, compound Sbt-119, ex and in vivo]. Vestnik VolgGMU [VolgSMU Herald]. 2011; 4: 19-21.
45. Keating G. Diquafosol ophthalmic solution 3 %: a review of its use in dry eye. Drugs. 2015; 75 (8): 911-922.
46. Baek J, Doh S, Chung S. The Effect of Topical Diquafosol Tetrasodium 3% on Dry Eye After Cataract Surgery. Curr Eye Res. 2016; 41 (10): 1281-1285.
47. Jin S, Min J. Clinical evaluation of the effect of diquafosol ophthalmic solution in glaucoma patients with dry eye syndrome. Jpn J Ophthalmol. 2016; 60: 150-155.
48. Jang HL, In SS, Sam YY et al. Effectiveness and Optical Quality of Topical 3,0% Diquafosol versus 0.05% Cyclosporine A in Dry Eye Patients following Cataract Surgery. J Ophthalmol.2016; doi:10.1155/2016/8150757.
49. Hwang H, Sung Y, Kim E. Additive Effect of preservative-free sodium hyaluronate 0.1% in treatment of dry eye syndrome with diquafosol 3% eye drops. Cornea. 2014; 33: 935-941.
50. Ratjen F, Durham T, Moss R. Long term effects of denufosol tetrasodium in patients with cystic fibrosis. J Cyst Fibros. 2012; 11: 539-549.

 


UDC [616.98:579.873.21]-078(048.8)

DOI: 10.20969/VSKM.2017.10(1).29-35

PDF downloadLABORATORY DIAGNOSIS OF MYCOBACTERIOSIS

LYAMIN ARTEM V., C. Med. Sci., associate professor of the Department of general and clinical microbiology, immunology and allergology of Samara State Medical University, Russia, 443079, Samara, Gagarin str., 18, tel. +7-846-260-33-61, e-mail: avlyamin@rambler.ru

ZHESTKOV ALEXANDER V., D. Med. Sci., professor, Head of the Department of general and clinical microbiology, immunology and allergology of Samara State Medical University, Russia, 443079, Samara, Gagarin str., 18, tel. +7-846-260-33-61, e-mail: avzhestkov2015@yandex.ru

ISMATULLIN DANIR D., 6-year student of faculty of preventative medicine of Samara State Medical University, Russia, 443079, Samara, Gagarin str., 18, tel. +7-846-260-33-61, e-mail: danirhalitov@mail.ru

KOVALYOV ALEXANDER M., C. Biol. Sci., biologist of bacteriological laboratory of N.V. Postnikov Samara Region Clinical Tuberculosis Dispensary, Russia, 443068, Samara, Novo-Sadovaya str., 154, tel. +7-927-659-06-24, e-mail: alexferreiro@yandex.ru

Abstract. Mycobacteriosis unifies a group of diseases characterized by lesions of various organs with predominant localization in bronchopulmonary system. One of the etiological features is extremely high diversity of pathogens belonging to the group of nontuberculous mycobacteria (NTMB). Aim. Analysis of modern data on the diagnosis of mycobacteriosis and NTM identification. Material and methods. Review of publications of national and foreign authors. The article analyses the peculiarities of laboratory diagnosis of mycobacteriosis based on the NTMB allocation from biological material and evaluation of their clinical significance. Results and discussion. Analysis of the recent studies has illuminated a modern view on the underlying causes of the rise in mycobacteriosis incidence. The basic features of pre-analytical phase, methods of decontamination, microscopic examination as well as clinical material cultivation are presented. Current identification methods and their comparative characteristics are described. Conclusion. There are no approved guidelines for the diagnosis of mycobacteriosis in Russia. Variety of NTMB, in its turn, requires optimization of the algorithms for their isolation and identification. The results from foreign publications show contradictory aspects of laboratory diagnosis of mycobacteriosis and require further research in this direction.

Key words: mycobacteriosis, nontuberculous mycobacteria, laboratory diagnosis.

For reference: Lyamin  AV, Zhestkov  AV, Ismatullin  DD, Kovalyov  AM. Laboratory diagnosis of mycobacteriosis. The Bulletin of Contemporary Clinical Medicine. 2017; 10 (1): 29—35. DOI: 10.20969/VSKM.2017.10(1).29-35.

References

1. Daley CL, Griffith DE. Pulmonary non-tuberculous mycobacterial infections. Int J Tuberc Lung Dis. 2010; 14 (6): 665–671.
2. Vejsfeller D. Biologija i izmenchivost’ mikobakterij tuberkuleza i atipichnye mikobakterii: jeksperimental’nye i teoreticheskie issledovanija [Biology and variability of Mycobacterium tuberculosis and atypical mycobacteria: an experimental and theoretical study]. Budapesht. 1975; 335 p.
3. Eliseev PI. Rol’ molekuljarno-geneticheskih metodov; Genotype v povyshenii jeffektivnosti diagnostiki tuberkuleza s lekarstvennoj ustojchivost’ju mikobakterij i mikobakteriozov [Role of molecular-genetic techniques; Genotype to improve the diagnosis of drug-resistant tuberculosis mycobacteria and mycobacteriosis]. Sankt-Peterburg [Saint Petersburg]. 2013; 23 p.
4. Majrova AA. Identifikacija netuberkuleznyh mikobakterij i vybor optimal’noj kombinacii metodov dlja ih vidovoj differenciacii [Identification of nontuberculous mycobacteria and the selection of the optimal combination of methods for species differentiation]. Moskva [Moscow]. 2007; 26 p.
5. Springer B, Stockman L, Tescher K et al. Two-laboratory collaborative study on identification of mycobacteria: molecular versus phenotypic methods. J Clin Microbiol. 1996; 34; 296–303.
6. Jergeshov AJe, Shmelev EI, Kovalevskaja MN, Larionova EE. Chernousova L.N. Netuberkuleznye mikobakterii u pacientov s zabolevanijami organov dyhanija (kliniko-laboratornoe issledovanie) [Non-tuberculous mycobacteria in patients with respiratory diseases (clinico-laboratory research)]. Pul’monologija [Pulmonology]. 2016; 26 (3): 303-308.
7. Al’hovik OI, Dymova MA, Cherednichenko AG. Rasprostranennost’ netuberkuleznyh mikobakterij v Sibiri [The prevalence of nontuberculous mycobacteria in Siberia]: Tezisy dokladov Vserossijskoj nauchno-prakticheskoj konferencii po medicinskoj mikrobiologii i klinicheskoj mikologii [Abstracts of all-Russian scientific-practical conference
on medical Microbiology and clinical Mycology]. XIX Kashkinskie chtenija Problemy medicinskoj mikologii [Problems in medical Mycology]. 2016; 37.
8. Dolgova VV, Men’shikova VV. Klinicheskaja laboratornaja diagnostika: nacional’noe rukovodstvo [Clinical diagnosis laboratornaja: national enterprise guide]. Moskva [Moscow]: GJeOTAR-Media. 2013; 808 p.
9. Adekambi T, Berger P, Raoult D, Drancourt M. RpoB gene sequence-based characterization of emerging non-tuberculous mycobacteria with descriptions of Mycobacterium bolletii sp nov, Mycobacterium phocaicum sp nov and Mycobacterium aubagnense sp nov. Int J Syst Evol Micr. 2006; 56: 133–143.
10. Tortoli E, Rindi L, Garcia MJ, Chiaradonna P, Dei R, Garzelli C et al. Proposal to elevate the genetic variant MAC-A, included in the Mycobacterium avium complex, to species rank as Mycobacterium chimaera sp nov. Int J Syst Evol Micr. 2004; 54: 1277–1285.
11. Griffith DE, Aksamit T, Brown-Eliot BA et al. An official ATS IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial disease. Am J Respir Crit Care Med. 2007; 175: 367–416.
12. Pye A, Hili SL, Bharadwa P. Effect of storage and postage on recovery and quantitation of bacteria in sputum samples. J Clin Pathol. 2008; 61: 352-354.
13. Mase SR, Ramsay A. Yield of serial sputum specimen examinations in the diagnosis of pulmonary tuberculosis: a systematic review. Int J Tuberc Lung Dis. 2007; 11: 485-495.
14. Sevast’janova EV, Golyshevskaja VI. Vyjavlenie tuberkuleza metodom mikroskopii [Detection method microscopy]. Tver’ [Tver]: Triada. 2008; 100 p.
15. Golyshevskaja VI. Sovremennoe sostojanie mikrobiologicheskoj diagnostiki tuberkuleza v Rossii [The modern state of microbiological diagnosis of TB in Russia]. Aktual’nye problemy tuberkuleza i boleznej legkih: materialy nauchnoj sessii, posvjashhennoj 85-letiju CNIIT RAMN [Actual problems of tuberculosis and lung disease: materials of scientific session dedicated to the 85th anniversary of the RAMS], Moskva [Moscow]. 2006; 17–18.
16. Golyshevskaja VI, Shul’gina MV, Erohin VV. Kul’tural’nye metody diagnostiki tuberkuleza: uchebnoe posobie dlja provedenija bazovogo kursa obuchenija specialistov bakteriologicheskih laboratorij uchrezhdenij protivotuberkuleznoj
sluzhby [Culture methods for diagnosis of tuberculosis: a training manual for conducting the basic course of training specialists of the bacteriological laboratory of the TB control service]. Tver’ [Tver]: Triada. 2008; 208p.
17. Lopakov KV, SabgajdaTP, Popov SA. Novyj integral’nyj pokazatel’ «Jepidemiologicheskij potencial tuberkuleza» social’nye aspekty zdorov’ja naselenija [New integrated indicator of «the potential Epidemiological tuberculosis»]. Social’nye aspekty zdorov’ja naselenija [Social aspects of population health]. 2009; 1: 4.
18. Perel’man MI, Korjakin VA, Protopopova NM. Tuberkulez [Tuberculosis]. Moskva [Moscow]: Medicina [Medicine]. 2002; 150-233.
19. Golyshevskaja VI, Sevast’janova EV, Irtuganova OA, Erohin VV. Sovremennoe sostojanie laboratornoj sluzhby Rossii po diagnostike tuberkuleza: osnovnye problemy i puti ih preodolenija [Modern state of the laboratory service of Russia in the diagnosis of tuberculosis: problems and ways of overcoming them]. Problemy tuberkuleza i boleznej legkih [Problems of tuberculosis and lung disease]. 2006; 12: 36–42.
20. Labinskaja AS, Kostjukova NN. Opportunisticheskie infekcii: vozbuditeli i jetiologicheskaja diagnostika [Opportunistic infections: causative agents and aetiological diagnosis]. Moskva [Moscow]: BINOM. 2013;
752 p.
21. McNabb AD, Eisler K, Adlie M, Amos M, Rodrigues G, Stephens WA, Black I, Renton J. Assessment of partial sequencing of the 65-kilodalton heat shock protein gene (hsp65) for routine identification of mycobacterium species isolated from clinical sources. J Clin Microbiol. 2004; 42: 3000–3011.
22. Tortoli E. Impact of genotypic studies on mycobacterial taxonomy: the new mycobacteria of the 1990’s. Clin Microbiol Rev. 2003; 2: 319–354.
23. Hall L, Doerr KA, Wohlfiel SL, Roberts GD. Evaluation of the MicroSeq system for identification of mycobacteria by 16S ribosomal DNA sequencing and its integration into a routine clinical mycobacteriology laboratory. J Clin Microbiol. 2003; 41: 1447–1453.
24. Huitt GA, Daley CL. Elsevier Clinic in chest medicine. Nontuberculous mycobacteria. 2015; 36 (1): 12

 

UDC [616.98:579.862.1]-057.36-084.47(048.8)

DOI: 10.20969/VSKM.2017.10(1).36-42

PDF downloadTHE RELEVANCE OF PREVENTATIVE VACCINATION AGAINST PNEUMOCOCCAL INFECTION IN ORGANIZED GROUPS OF MILITARY PERSONNEL

SHUBIN IGOR V., C. Med. Sci., Honored Doctor of the Russian Federation, Head of the Сlinical vaccinology laboratory of Scientific Research Institute of Pulmonology, 105077, Moscow, 11th Parkovaya str., 32, build. 4, chief therapist of Army Medical Department of Chief Command of Interior troops of the Ministry of Internal Affairs of Russia, 111250, Moscow, Krasnokazarmennaya str., 9a, e-mail: shubin-igor@mail.ru

Abstract. Pneumococcal disease is a serious problem in Russia and all around the world. It acquires special relevance in organized groups of servicemen due to a high people concentration and, consequently, large number of healthy pneumococci carriers in the team. Aim. Identification of the relevance of pneumococcal vaccination in organized servicemen groups. Material and methods. Analysis of publications and statistical data on the problem of pneumococcal disease in organized servicemen groups. Results and discussion. A number of adverse factors that accompany military service lead to a large number of non-invasive and invasive pneumococcal infection cases. They hereby cause harm for health. Complications of pneumococcal disease that are particularly difficult to occur, are often leading to death. In addition, the high incidence leads to high economic losses. Among various preventive measures carried out by the Command and troop medical service, the priority is given to vaccination. Conclusion. Vaccination against pneumococcus allows reducing the incidence of invasive and non-invasive pneumococcal infections several times in organized servicemen groups.

Key words: pneumococcus, pneumonia, vaccination, military personnel.

For reference: Shubin IV. The relevance of preventative vaccination against pneumococcal infection in organized groups of military personnel. The Bulletin of Contemporary Clinical Medicine. 2017; 10 (1): 36—42. DOI: 10.20969/VSKM.2017.10(1).36-42.

References

1. Prikaz Federal’noj sluzhby gosudarstvennoj statistiki ot 31 dekabrja 2010 goda №482 [Order of the Federal State Statistics Service on December 31, 2010 №482].
2. Ezhlova EB, Mel’nikova AA, Baranov AA et al. Immunizacija polisaharidnoj polivalentnoj vakcinoj dlja profilaktiki pnevmokokkovoj infekcii: metodicheskie rekomendacii [Immunization with polyvalent polysaccharide vaccine for the prevention of pneumococcal disease: guidelines]. Moskva [Moscow]: Federal’nyj centr gigieny i jepidemiologii Rospotrebnadzora [Federal Center of Hygiene and Epidemiology]. 2008; 14 p.
3. Tatochenko VK, Ozereckovskij NA, Fedorov AM. Immunoprofilaktika  — 2014: Spravochnik [Immunization  — 2014: Guide]. Moskva [Moscow]: Pediatr## [Pediatr]. 2014; 199 p.
4. Chuchalin AG, Shubin IV, Bashtovoj MA et al. Aktual’nye voprosy diagnostiki i lechenija grippa v pandemicheskij period (po materialam XIX-XX Nacional’nyh kongressov po boleznjam organov dyhanija) [ Current problems in the diagnosis and treatment of influenza in the pandemic period (based on xux-XX National Congress on respiratory diseases)]. Medicinskii vestnik MVD [Medical Bulletin MIA]. 2011; L (1): 13-17.
5. Jaroslavcev VV, Sabanin JuV, Kas’kov OV et al. Vnebol’nichnaja pnevmonija u voennosluzhashhih vnutrennih vojsk MVD Rossii: osobennosti jepidemicheskogo processa [Community-acquired pneumonia in servicemen of internal troops of Russia: features of epidemic process]. Voenno  — medicinskii zhurnal [Military Medical Journal]. 2011; 11: 40-43.
6. Rajcheva MV, Shubin IV, Marsova LA [et al]. Jetiologicheskaja diagnostika vnebol’nichnoj pnevmonii u molodyh muzhchin
v organizovannyh kollektivah s ispol’zovaniem testa «BinaxNOW®» [The etiological diagnosis of community-acquired pneumonia in young men in organized groups using a test «BinahNOSch®»]. Medicinskii vestnik MVD [Medical Bulletin MIA]. 2011; LI (2): 61.
7. Rajcheva MV, Bilichenko TN, Shubin IV et al. Vlijanie novogo virusa grippa A (H1N1) na chastotu gospitalizacii po povodu pnevmonii v organizovannyh kollektivah [The impact of the new virus influenza A (H1N1) at the rate of hospitalization for pneumonia in organized groups]. Medicinskii vestnik MVD [Medical Bulletin MIA]. 2013; LHII (1): 57-61.
8. Rybin VV, Kas’kov OV, Jaroslavcev VV et al. Nekotorye jepidemiologicheskie aspekty boleznej organov dyhanija vo vnutrennih vojskah MVD Rossii [Some epidemiological aspects of respiratory diseases in the internal troops of the Russian Interior Ministry]. Voenno  — medicinskii zhurnal [Military Medical Journal]. 2012; 7: 28-31.
9. Sinopal’nikov AI, Kozlov RS. Vnebol’nichnye infekcii dyhatel’nyh putej: diagnostika i lechenie: rukovodstvo dlja vrachej [Community-acquired respiratory tract infections: diagnosis and treatment. Guidelines for doctors]. Moskva: Izdatelskiy dom «M-Vesti» [Moscow: Publishing House «M-Vesti»]. 2008; 272 p.
10. Chuchalin AG, Sinopal’nikov AI, Kozlov RS et al. Vnebol’nichnaja pnevmonija u vzroslyh: prakticheskie rekomendacii po diagnostike, lecheniju i profilaktike [Community-acquired pneumonia in adults: practical recommendations for diagnosis, treatment and prevention]. Moskva: MAKMAH [Moscow: IACMAC]. 2010; 54 p.
11. Shubin IV, Rajcheva MV, Bashtovoj MA, Chuchalin AG. Sovremennye podhody k diagnostike i lecheniju grippa v pandemicheskij period [Current approaches to diagnosis and treatment of influenza in the pandemic period]. Voenno  — medicinskii zhurnal [Military Medical Journal]. 2010; 331 (4): 27-32.
12. Shubin IV, Chuchalin AG. Diagnostika i lechenie ostryh respiratornyh virusnyh infekcij, grippa i grippoznoj pnevmonii [Diagnosis and treatment of acute respiratory viral infections, influenza and influenza pneumonia]. Zhurnal «Poliklinika» [«Clinic» Magazine]. 2011; 2: 63-66.
13. Chuchalin AG, Sinopal’nikov AI, Kozlov RS et al. Klinicheskie rekomendacii po diagnostike, lecheniju i profilaktike tjazhjoloj vnebol’nichnoj pnevmonii u vzroslyh [Clinical Recommendations for diagnosis, treatment and prevention of severe community-acquired pneumonia in adults]. Moskva [Moscow]: Izdatelskiy dom «M-Vesti» [Publishing. House «M-Vesti»]. 2014; 92 p.
14. Shubin IV, Budul JuI, Rajcheva MV et al. Metodicheskie ukazanija «Diagnostika, lechenie i profilaktika vnebol’nichnoj pnevmonii vo vnutrennih vojskah MVD Rossii» [Methodical guidelines «Diagnosis, treatment and prevention of community-acquired pneumonia in the Interior Troops of Russia]. Moskva: GKVV MVD Rossii [Moscow: Russian Ministry of Internal Affairs GKVV]. 2013; 2: 74 p.
15. Benja FM, Shevchuk PA, Rahcheev SV. Opyt immunoprofilaktiki vnebol’nichnoj pnevmonii v voinskih kollektivah [Experience the immunization community-acquired pneumonia in military units]. Voenno  — medicinskii zhurnal [Military Medical Journal]. 2008; 12: 39-41.
16. Sabanin JuV. Vakcinoprofilaktika aktual’nyh infekcij v sisteme protivojepidemicheskih meroprijatij vo vnutrennih vojskah MVD Rossii : dissertacija doktora medicinskih nauk [Vaccination of topical infections in the system of anti-epidemic measures in Internal Forces of Russia: the dissertation of the doctor of medical sciences]. Moskva [Moscow]. 2009; 283 p.
17. Gladinec IV, Ivashhenko AN, Rybin VV et al. O sovershenstvovanii profilaktiki ostryh boleznej organov dyhanija vo vnutrennih vojskah MVD Rossii [On improving the prevention of acute respiratory diseases in Internal Forces ofRussia]. Medicinskii vestnik MVD [Medical Bulletin MIA]. 2014; 2 (69): 29-34.
18. Zhogolev SD, Ogarkov PI, Zhogolev PD et al. Jepidemiologija i profilaktika vnebol’nichnyh pnevmonij u voennosluzhashhih
[Epidemiologiya and prevention of community-acquired pneumonia in the military]. Voenno  — medicinskii zhurnal [Military Medical Journal]. 2013; 11: 55-60.
19. Sabanin JuV, Rihter VV, Rybin VV et al. Specificheskaja profilaktika vnebol’nichnoj pnevmonii vo vnutrennih vojskah MVD Rossii [Specific prevention of community-acquired pneumonia in the internal troops of the Russian Interior Ministry]. Voenno  — medicinskii zhurnal [Military Medical Journal]. 2008; 10: 31-34.
20. Bajturov OR, Shubin IV. Nizkaja adaptacija voennosluzhashhih novogo popolnenija kak odin iz faktorov razvitija zabolevanij i simptomov, v chastnosti, dlitel’nogo subfebriliteta [Slow adaptation of servicemen of the new replenishment as one of the factors in the development of diseases and conditions, in particular, long subfebrile]. Medicinskii vestnik MVD [Medical Bulletin MIA]. 2014; LHVIII (1): 28-32.
21. Belevitin AB, Akimkin VG, Mosjagin VD et al. Organizacionno-jepidemiologicheskie aspekty profilaktiki vnebol’nichnoj pnevmonii v voinskih kollektivah [Organizational and epidemiological aspects of the prevention of community-acquired pneumonia in military units]. Voenno  — medicinskii zhurnal [Military Medical Journal]. 2009; 9: 56-63.
22. O’Shea MK et al. Respiratory infections in the military. J R Army Med Corps. 2013; 159: 181–189.
23. Budul JuI. Mediko-jekonomicheskoe obosnovanie immunizacii voennosluzhashhih po prizyvu vnutrennih vojsk MVD Rossii vakcinoj «Pnevmo23» [Medico-economic assessment of immunization conscripts of internal troops of the Russian Interior Ministry vaccine «Pnevmo23»]. Aktual’nye problemy medicinskogo obespechenija vojsk (sil) na strategicheskih napravlenijah: sbornik tezisov dokladov Vsearmejskoj nauchno-prakticheskoj konferencii 22 nojabrja 2013 goda [Actual problems of medical support
of troops (forces) in strategic areas: abstracts of the All-Army scientific and practical conference November 22, 2013]. SPb: VMedA [Saint Petersburg: MMA]. 2013; 13-14.

 

ORGANIZATION OF HEALTHCARE

UDC 614.2(470.331):616-082

DOI: 10.20969/VSKM.2017.10(1).43-47

PDF downloadTOPICAL ISSUES OF PRIMARY HEALTH CARE INCIDENCE

BERSENEVA EVGENIA A., D. Med. Sci., Head of Higher and supplementary professional education department of N. Semashko National Research Institute of Public Health, Russia, 105064, Moscow, Vorontsovo Pole str., 12/1, build. 1, tel. +7-916-216-84-59, e-mail: eaberseneva@gmail.com

LALABEKOVA MARINA V., vice-principal on public relations and discipline of N. Pirogov Russian National Research Medical University, Russia, 117997, Moscow, Ostrovityanova str., 1, tel. + 7-903-295-66-81, e-mail: lalabekova_mv@rsmu.ru

CHERKASOV SERGEY N., D. Med. Sci., chief research worker of N. Semashko National Research Institute of Public Health, Russia, 105064, Moscow, Vorontsovo Pole str., 12/1, build. 1, tel. + 7-967-079-68-96, e-mail: cherkasovsn@nriph.ru

MESHKOV DMITRY O., D. Med. Sci., Head of scientific research coordination sector of N. Semashko National Research Institute of Public Health, Russia, 105064, Moscow, Vorontsovo Pole str., 12/1, build. 1, tel. + 7-985-179-10-83, e-mail: meshkovdo@nriph.ru

Abstract. Topical issues of primary health care volume territory planning in the Tver region of the Russian Federation are considered in the article. Aim. Study of territorial features of primary health care incidence in the Tver region of the Russian Federation. Material and methods. The research was conducted according to statistical accounting of primary health care incidence in the Tver region. The incidence was studied on 5 types of territories different in population structure as well as in medical care access and primary incidence levels. Results and discussion. Standard rates were developed for primary health care volume planning taking into account the features of the territory. Dependence of the incidence on age, gender, place of residence and primary incidence level was proved both for medical and pre-medical healthcare levels. Conclusion. On the basis of the results received, we find it possible to recommend using the standards in various territorial subjects of the Russian Federation.

Key words: primary health-care, territorial planning, standard rates of medical care volume.

For reference: Berseneva EA, Lalabekova MV, Meshkov DO, Cherkasov SN. Topical issues of primary health care incidence. The Bulletin of Contemporary Clinical Medicine. 2017; 10 (1): 43—47. DOI: 10.20969/VSKM.2017.10(1).43-47

References

1. Habriev RU, Lindenbraten AL, Komarov JuM. Strategii ohrany zdorov’ja naselenija kak osnova social’noj politiki gosudarstva [Population Health strategies as basis of social policy of the state]. Problemy social’noj gigieny, zdravoohranenija i istorii mediciny [Problems of social hygiene, health care and history of medicine]. 2014; 3: 3-5.
2. Shherbakov DV. Problemy planirovanya i ocenki potrebnosti naselenya v specializirovannoy (v tom chisle vyisokotehnologichnoy) medicinskoy pomoshhi [Problems of planning and assessment of need of the population for specialized medical care]. Rossijskaja akademija medicinskih nauk; Bjulleten’ Nacional’nogo nauchno-issledovatel’skogo instituta obshhestvennogo zdorov’ja [Russian academy of medical sciences; Bulletin of National research institute of public health]. 2014; 1: 327-329.
3. Shipova VM, Voroncov TN. Sovremennye problem planirovanija medicinskoj pomoshhi [Modern problems of medical care planning]. Rossijskaja akademija medicinskih nauk; Bjulleten’ Nacional’nogo nauchno-issledovatel’skogo instituta obshhestvennogo zdorov’ja [Russian academy of medical sciences; Bulletin of National research institute of public health]. 2014; 1: 306-310.
4. Shhepin VO, Rastorgueva TI, Karpova OB. Sovremennye demograficheskie tendencii v Possijskoj Federacii [Current demographic trends in the Russian Federation]. Rossijskaja akademija medicinskih nauk. Bjulleten’ Nacional’nogo nauchno-issledovatel’skogo instituta obshhestvennogo zdorov’ja [Russian academy of medical sciences. Bulletin of National research institute of public health]. 2013; 2: 10-13.
5. Cherkasov SN, Kurnosikov MS, Sopova IL. Ispol’zovanie demograficheskogo analiza pri planirovanii ob#emov medicinskoj pomoshhi [Population analysis use when planning medical care amounts]. V sbornike: Jekologija I zdorov’e cheloveka na Severe sbornik nauchnyh trudov VI-go Kongressa s mezhdunarodnym uchastiem; Pod redakciej Petrova PG [In the collection: Ecology and health of the person in the north the collection of scientific works of the VI Congress with the international participation; Under Petrov P edition]. 2016: 601-605.
6. Lalabekova MV, Cherkasov SN, Berseneva EA, Meshkov DO. Demograficheskie process na territorii Tverskoj oblasti za period s 1994 po 2015 [Demographic processes in the territory of the Tver region from 1994 for 2015]. Rossijskaja akademija medicinskih nauk. Bjulleten’ Nacional’nogo nauchno-issledovatel’skogo instituta obshhestvennogo zdorov’ja [Russian academy of medical sciences. Bulletin of National research institute of public health]. 2015; 6: 87-100.
7. Berseneva EA. Informacionnye sistemy v upravlenii lechebno-profilakticheskim uchrezhdeniem [Information systems in medical organization management]. Vrach i informacionnye tehnologii [Doctor and information technologies]. 2006; 4: 75-76.
8. Berseneva EA. Aktual’nye voprosy sozdania avtomatizirovannoy sistemy rascheta ob’emov pervichnoy medico-sanitarnoy pomoshhi v Tverskoy oblasty [Topical issues of tver region primary health care volumes calculation automated system creation]. Vestnik sovremennoy klinicheskoy mediciny [The Bulletin of Contemporary Clinical Medicine]. 2016; 9 (4): 15-20.

 

ORIGINAL RESEARCH

UDC 616.367-003.7-089

DOI: 10.20969/VSKM.2017.10(1).48-53

PDF downloadMINIMALLY INVASIVE TREATMENT OF PATIENTS WITH MASSIVE MULTIPLE CHOLEDOCHOLITHIASIS

ABRAMOVA ALISA G., graduate student of the Department of surgery of Yaroslavl State Medical University, Russia, 150023,  Yaroslavl, Gagarin str., 12, tel. 8-920-655-67-96, e-mail: Aliceabramova@rambler.ru

KHOREV ALEXANDER N., D. Med. Sci., professor, Head of the Department of surgery of Yaroslavl State Medical University, Russia, 150023, Yaroslavl, Gagarin str., 12, tel. 8-902-330-51-11, e-mail: khorev48@mail.ru

KOZLOV SERGEY V., C. Med. Sci., associate professor of the Department of surgery of Yaroslavl State Medical University,
Russia, 150023, Yaroslavl, Gagarin str., 12, tel. 8-920-656-25-25, e-mail: SVKy@yandex.ru

PLJUTA ANDREY V., C. Med. Sci., associate professor of the Department of surgery of Yaroslavl State Medical University,
Russia, 150023, Yaroslavl, Gagarin str., 12, tel. 8-905-634-01-96

BLAGOV DMITRIY A., C. Med. Sci., associate professor of the Department of surgery of Yaroslavl State Medical University, Russia, 150023, Yaroslavl, Gagarin str., 12, tel. 8-903-825-76-83, e-mail: D-Blagov@yandex.ru

KLOKOV VADIM A., C. Med. Sci., assistant of professor of the Department of surgery of Yaroslavl State Medical University, Russia, 150023, Yaroslavl, Gagarin str., 12, tel. 8-903-691-07-37, e-mail: klokov-mail@yandex.ru

ABRAMOV GARIK S., surgeon of Clinical hospital №10, Russia, 150023, Yaroslavl, Gagarin str., 12, tel. 8-930-103-12-70,
e-mail: Garikabramov59@gmail.com

Abstract. Aim. To evaluate clinical effect of minimally invasive choledocholithiasis surgery. Material and methods. We conducted an analysis of minimally invasive surgical treatment of 198 massive multiple choledocholithiasis cases. The patients have been divided into 4 groups according to the surgical method: Group A  — 68 patients with endoscopic papillosphincterotomy, lithotripsy, lithoextraction; Group B  — 30 patients with mini laparotomy, choledochotomy, lithoextraction, mechanical dilation of the major duodenal papilla and internal drainage of the common bile duct; Group C  — 46 patients with mini laparotomycholedochotomy, lithoextraction and choledochoduodenostomy; Group D  — 54 patients with mini laparotomy, choledochotomy, lithoextraction and external drainage of the common bile duct by T-tube. Evaluation criteria: duration of analgesia and antibiotic treatment, intestinal paresis, normalization of bilirubin and leukocyte level, hospitalization, operative and postoperative complications. Results and discussion. We have found the biggest number of operative complications in group A. In 16 cases we used conversion to open surgery. Duration of analgesia, antibiotic treatment, normalization of white blood cells and bilirubin levels was significantly lower in groups B and D comparing to A and C. Minimal duration of intestinal paresis has been observed in the groups with mini laparotomy performed. In most cases postoperative complications were found in patients from groups A and C. Traumatic removal of drainage was not present in group B. Conclusion. Mini laparotomy access radically reduces duration of hospitalization. It also allows performing different manipulations on the common bile duct. Mechanical dilatation of the major duodenal papilla is less traumatic comparing to endoscopic papillosphincterotomy. Internal drainage of the common bile duct prevents the stricture of the common bile duct and of the major duodenal papilla. It can be easily removed.

Key words: choledocholithiasis, choledochotomy, mini laparotomy, internal drainage of the common bile duct, endoscopic papillosphincterotomy.

For references: Abramova AG, Khorev AN, Kozlov SV, Pljuta AV, Blagov DA, Klokov VA, Abramov GS. Minimally invasive treatment of patients with massive multiple choledocholithiasis. The Bulletin of Contemporary Clinical Medicine. 2017; 10 (1): 48—53. DOI: 10.20969/VSKM.2017.10(1).48-53.

References

1. Razmahnin EV, Hyshiktuev BS, Lobanov SL. Kontaktnaja litotripsija pri lechenii holedoholitiaza [Contact lithotripsy in treatment of choledocholithiasis]. Hirurgija; Zhurnal imeni NI Pirogova [Surgery; Journal behalf of NI Pirogov]. 2014; 7: 34-37.
2. Boboev BD. Rezul’taty odnomomentnogo laparoskopicheskogo lechenija bol’nyh holecistoholedoholitiazom [Results of One-Step laparoscopic management of the cholecystocholedocholithiasis patients]. Analy hirurgicheskoj gepatologii [Annals of surgical hepatology]. 2012; 4 (17): 80-83.
3. Durleshter VM, Gabriel SA, Dynko VY et al. Jeffektivnost’ kompleksnogo primenenija maloinvazivnyh metodik v lechenii bol’nyh s holedoholitiazom [The efficiency of complex application minimally invasive methods in treatment of patients with choledocholithiasis]. Vestnik hirurgicheskoj gastrojenterologii [Bulletin Surgical Gastroenterology]. 2012; 4: 15-21.
4. Agadzhanov VG, Shulutko AM, Chanturija MO et al. Povrezhdenie magistral’nyh zhelchnyh protokov pri holecistjektomii iz mini-dostupa [Damage to the main bile duct during cholecystectomy from the minimal access]. Jendovideohirurgija zhelchnokamennoj bolezni segodnja: problemy i puti ih preodolenija: materialy vyezdnogo plenuma pravlenija ROJeH [Endovideosurgery cholelithiasis today: problems and ways to overcome them: materials of plenum of the ROEH]. 2012;
18-20.
5. Piecuch J, Witkowski K. Biliary tract complications following 52 consecutive orthotopic liver transplants. Ann Transplant. 2001; 1: 36-38.

 

UDC 616.12-008.331.1-082

DOI: 10.20969/VSKM.2017.10(1).53-59

PDF downloadEXPERT QUALITY ASSESSMENT PRIMARY HEALTH CARE TO THE POPULATION WITH ARTERIAL HYPERTENSION

АTSEL EVGENIA А., C. Med. Sci., associate professor of the Department of therapy, geriatrics and family medicine KSMA  — Branch of the FSBEI АPE RMACPE MOH, Russia, 420012, Kazan, Mushtari str., 11, e-mail: atzel@mail.ru

FOMINA ANNA V., C. Farm. Sci., professor, Head of the Department of public health and health FSAEI HE PFUR, Russia, 117198, Moscow, Miclukho-Maclay str., 6, e-mail: anutyk74@mail.ru

Abstract. Aim  — expert evaluation of the quality of primary care patients with hypertension. Material and methods. Spend peer review 347  cases of primary health care to patients with arterial hypertension in the conditions of organizational experiment, and 172  cases of primary health care to patients with arterial hypertension of the comparison group. Compared groups were comparable in terms of the basic characteristics of the analyzed diseases. Among patients with arterial hypertension accounted for the largest proportion of patients with stage III disease (53,0 and 52,3% respectively), and 4 risk of cardiovascular events (68,8 and 72,3% respectively). Results and discussion. As a result of the experiment in the study group showed a statistically significant reduction in defect rate in diagnosis (p<0,001), history-taking (p<0,001) describing objective status (p<0,001), laboratory and instrumental diagnosis (p<0,001), treatment (p<0,001), in addition to the use of drugs by the standards, but with polypharmacy and/or polytherapy (p>0,05). Conclusion. As a result of the carried-out expert assessment the statistical importance of efficiency of the made organizational experiment regarding realization in educational process of programs of professional development of doctors of primary link of health care concerning improvement of quality of diagnostics and treatment of diseases of the blood circulatory system was revealed.

Key words: quality of medical care, expert assessment, arterial hypertension.

For reference: Atsel EA, Fomina  AV. Expert assessment of quality of rendering primary medical and sanitary help to the population with an arterial hypertension. The Bulletin of Contemporary Clinical Medicine. 2016; 10 (1): 53—59. DOI: 10.20969/VSKM.2017.10(1).53-59.

References

1. Vyalkov AI. Kucherenko VZ. Klinicheskij menedzhment [Clinical management]. Moskva. Medicina [Medicine]. 2006; 304 р.
2. Kucherenko VZ., Razlivinskikh LP, Martynenko VF. Metodicheskie podhody k ocenke dejatel’nosti lechebno-diagnosticheskogo uchrezhdenija: monitoringovye indikatory, pokazateli, kriterii, opredelenija. [Methodological approaches to the evaluation of the diagnostic and treatment institution: monitoring indicators, indicators, criteria, definitions]. Jekonomika zdravoohranenija [Health care economy]. 2006; 8: 19-36.
3. Ryabenko D. Several problems of congestive heart failure pharmacotherapy. Ukrainian cardiology journal. 2009; 3: 94-102.
4. Aleksandrova OJ., Nagibin OA, Gorelov MV. Problemy realizacii prava grazhdanina na vybor medicinskoj organizacii i vracha dlja poluchenija pervichnoj mediko-sanitarnoj pomoshhi. [Problems of realization of the citizen’s right to choose medical organizations and doctors to provide primary health care]. Zdravoohranenie [Health care]. 2013; 5: 80-88.
5. Vlasenkova VV. Pravo na ohranu zdorov’ja i medicinskuju pomoshh’ v Rossijskoj Federacii. Аvtoref. dis. … kand. juridich. nauk: 12.00.05. [Right to health and health care in the Russian Federation: the Author. Dis. ... Cand. Legal. Science]. Vlasenkova Veronika Viktorovna. Moskovskij gosudarstvennyj universitet im. M.V. Lomonosova [Lomonosov Moscow State University]. Moskva. 2007; 20 p.
6. Shulaev AV. Upravlenie kachestvom otorinolaringologicheskoj pomoshhi na ambulatorno-poliklinicheskom jetape (na primere Respubliki Tatarstan) — avtoreferat dissertacii kandidata medicinskih nauk [Quality management of the otorinolaringologichesky help at an out-patient and polyclinic stage (on the example of the Republic of Tatarstan): the abstract of the thesis on competition of an academic degree of the candidate of medical sciences]. Kazanskij gosudarstvennyj medicinskij universitet [Kazan state medical university]. 2005; 19 p.
7. Indeikin EN. Klinicheskij audit: opyt Velikobritanii [Clinical audit: the experience of the UK]. Kachestvo medicinskoj pomoshhi [Quality of medical care]. 2002; 2: 45-53.
8. Murray CJ, Lopez AD, Murray CJ еt al. Global burden of disease and injury series; the global burden of disease; a comprehensive assessment of mortality and disability from diseases, injuries, and risk factors in 1990 and projected to 2020. Geneva: WHO. 1996; 1: DOI: 10.1596/978-0-8213-6262-4.

 

UDC 616.72-002.77-085.275.3

DOI: 10.20969/VSKM.2017.10(1).65-70

PDF downloadEVIDENCE-BASED APPROACH TO BIOLOGICAL AGENTS IN RHEUMATOID ARTHRITIS. DATA FROM MOSCOW COMMON ARTHRITIS REGISTRY

ZHILYAEV EVGENY V., D. Med. Sci., professor of the Department of rheumatology of Russian Medical Academy of continuing professional education, acting chief doctor of CJSC «European Medical Center», Russia, 125993, Moscow, Barrikadnaya str., 2/1, tel. 8-499-252-21-04, e-mail: zhilyayevev@mail.ru

MEZENOVA TATIANA V., C. Med. Sci., associate professor of the Department of rheumatology of Russian Medical Academy of continuing professional education, Russia, 125993, Moscow, Barrikadnaya str., 2/1

LUKINA GALINA V., D. Med. Sci., professor of V.A. Nasonova Research Institute of Rheumatology, Head of the Moscow City Rheumatological Center, Russia, 115522, Moscow, Kashirskoe shosse, 34а

KOLTSOVA EKATERYNA N., Head of the organizational-methodical Division of Rheumatology Research Institute of the Organization of health and healthcare management, Russia, 115184, Moscow, Bolshaya Tatarskaya str., 30

SCHMIDT EUGENIJA I., C. Med. Sci., Head of the Department of rheumatology of N.I. Pirogov City Clinical Hospital № 1,
Russia, 117049, Moscow, Leninsky ave., 8

Abstract. The goal of the study is to identify the signs that allow to choose a biologic drug for a patient with rheumatoid arthritis to achieve minimal disease activity. Material and methods. The study includes 361 rheumatoid arthritis patients meeting the classification criteria of ACR (1987) or ACR/EULAR (2010) from the Moscow Arthritis Registry (MAR), who received a targeted disease modifying anti-rheumatic drug provided using funds from the regional or federal budget. In the process of enrollment through a survey, data were collected about clinical manifestations of the disease at the onset and subsequently. Upon enrollment and during every subsequent visit, activity was evaluated using DAS28(ESR). The search for choice predictors was conducted using a specially built multi-factor mathematical model with the achieved DAS28(ESR) value used as a dependent variable. A systematic search was conducted to identify parameters demonstrating, within the model, a significant interaction with the factor of the used biologic drug. Results and discussion. Smoking and the type of disease onset (acute or gradual), as well as tender and swollen elbow and shoulder joints at the onset of rheumatoid arthritis were identified as the most important factors for choice of drug. Smokers/ex-smokers demonstrated better results of the therapy with abatacept or rituximab and relatively poor results with TNFα inhibitors. In case of acute rheumatoid arthritis onset, better results were observed with abatacept. When complaints at the disease onset included tender, swollen elbow joints and swollen shoulder joints, better clinical-laboratory results were reported with abatacept and rituximab. Conclusion. Personalization of treatment with targeted drugs may be achieved by identifying clinical markers. The history of smoking and the clinical characteristic of disease onset are very important for the selection of an effective anti-cytokine medication.

Key words: rheumatoid arthritis, genetically engineered biological drugs, drug selection.

For reference: Zhilyaev EV, Mezenova TV, Lukina GV, Koltsova EN, Schmidt EI. Evidence-based approach to biological agents in rheumatoid arthritis. Data from Moscow common arthritis registry. The Bulletin of Contemporary Clinical Medicine. 2017; 10 (1): 65—70. DOI: 10.20969/VSKM.2017.10(1).65-70.

References

1. Nasonov EL, Mazyrov VI, Karateev DE et al. Mezhdunarodnye i rossijskie rekomendacii po lecheniju revmaticheskih zabolevanij. Proekt rekomendacij po lecheniju revmatoidnogo artrita Obshherossijskoj obshhestvennoj organizacii «Associacija revmatologov Rossii» [International and Russian recommendations on the treatment of rheumatic diseases; Draft recommendations for the treatment of rheumatoid arthritis of the all-Russian public organization “Association of rheumatologists of Russia»]. Nauchno-prakticheskaya revmatologiya [Rheumatology Science and Practice]. 2014; 52 (5): 477-494.
2. Smolen JS, Landewé R, Breedveld FC et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update. Ann Rheum Dis. 2014; 73 (3): 492-509.
3. Singh JA, Saag KG, Bridges SL et al. 2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis. Arthritis Care & Research. 2016; 68 (1): 1–25.
4. Smolen JS, Breedveld FC, Burmester GR et al. Treating rheumatoid arthritis to target: 2014 update of the recommendations of an international task force. Ann Rheum Dis. 2016;75 (1): 3-15.
5. Lehmann EL, Romano JP. Multiple testing and simultaneous inference. Testing statistical hypotheses, 3rd ed. New York: Springer. 2005; 786 p.
6. Konski A, Berkey BA, Kian Ang K. Effect of education level on outcome of patients treated on Radiation Therapy Oncology Group Protocol 90-03. Cancer. 2003; 98 (7): 1497-1503.
7. Kane CJ, Lubeck DP, Knight SJ et al. Impact of patient educational level on treatment for patients with prostate cancer: data from CaPSURE. Urology. 2003;62 (6): 1035-1039.
8. Zhilyaev EV. Efficacy of biologic treatment in cohort of rheumatoid arthritis patients in Moscow. Int J Rheum Dis. 2014; 17 (2): 8.
9. Busquets N, Carmona L, Surisa X. Systematic review: Safety and efficacy of anti-TNF in elderly patients. Rheumatol Clin. 2011; 7 (2): 104-112.
10. Cuppen BV, Welsing PM, Sprengers JJ et al. Personalized biological treatment for rheumatoid arthritis: a systematic review with a focus on clinical applicability. Rheumatology. 2016; 55: 826-839.
11. Soderlin MK, Petersson IF, Geborek P. The effect of smoking on response and drug survival in rheumatoid arthritis patients treated with their first anti-TNF drug. Scand J Rheumatol. 2012; 41 (1): 1-9.
12. Mattey DL, Brownfield A, Dawes PT. Relationship between pack-year history of smoking and response to tumor necrosis factor antagonists in patients with rheumatoid arthritis. J Rheumatol. 2009; 36 (6): 1180-1187.
13. Hyrich KL, Watson KD, Silman AJ et al. Predictors of response to anti-TNF-alpha therapy among patients with rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register. British Society for Rheumatology Biologics Register. Rheumatology (Oxford). 2006; 45 (12): 1558-1565.

 

UDC 615.225.2:615.12:339.133.017(470.41-25)

DOI: 10.20969/VSKM.2017.10(1).71-78

PDF downloadCONSUMPTION OF CARDIO-VASCULAR MEDICATIONS PURCHASED FROM PRIVATE PHARMACY CHAIN BY POPULATION?

TUKHBATULLINA RUZALIA G., D. Pharm. Sci., professor of Russian Academy of Natural Science, Head of the Department of pharmaceutical technologies of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. +7-917-266-45-66, e-mail: Ruzaliyatuhbatullina@mail.ru

NAGAEVA ALINA R., Marketing Director of «RAN» Ltd, Russia, 420043, Kazan, Kalinin str., tel. +7-987-296-34-26, е-mail: nagaevaalina2011@yandex.ru

Abstract. Aim.To study the structure of consumption of medication used for cardio-vascular diseases treatment purchased from private pharmacy chain «Saulyk» Ltd, Kazan. Material and methods. Analysis of reports on performance indicators related to the purchase and marketing of medications used for cardio-vascular diseases treatment, of the pharmacy chain «Saulyk» Ltd was performed. The analysis was carried out using comparative, systemic, and economic methods and methodology of WHO  — АТС/DDD for 2011-2013. Calculations included the data on the package number of medicines sold annually during the studied period (thousand units) in the private pharmacy chain «Saulyk» Ltd, as well as the amount of active ingredient in a pill, the number of pills and values of DDD according to the data taken from the WHO website. Results and discussion. The analysis of disposal of the medications used for cardio-vascular diseases treatment showed that ACE inhibitors are ranked first in the total number of packages sold during the studied period in the pharmacy № 6 of the «Saulyk» Ltd chain. Beta-blockers were ranked second being followed by calcium channel blockers, antiarrhythmic and other groups of medications. Conclusion. АТС/DDD methodology allows to calculate the medication consumption by population. It helps to improve the quality and availability of medications for the population due to the timely drug purchase during the first patient visit to the pharmacy. Carried out disposal analysis allows to guarantee availability of the necessary medicines.

Key words: anatomic/therapeutic/chemical classification, methodology АТС/DDD, prescribed daily dose, medicine consumption, cardio-vascular diseases.

For reference: Tukhbatullina  RG, Nagaeva  AR. Consumption of cardio-vascular medications purchased from private pharmacy chain by population. The Bulletin of Contemporary Clinical Medicine. 2017; 10 (1): 71—78. DOI: 10.20969/VSKM.2017.10(1).71-78.

References

1. Chazova IE, Oshhepkova EV. Bor’ba s serdechno-sosudistymi zabolevanijami: problemy i puti ih reshenija na sovremennom jetape [The fight against cardiovascular disease: problems and ways to solve them at the present stage]. Vestnik roszdravnadzora [Bulletin Roszdravnadzor]. 2015; 5: 7–8.
2. Spravka k rasshirennomu zasedaniju kollegii ministerstva zdravoohranenija RT [Reference to an expanded meeting of the collegium of the RT Ministry of Health]. Itogi dejatel’nosti sistemy zdravoohranenija RT v 2015 godu: osnovnye napravlenija strategii razvitija do 2030 goda [The results of RT health care system in 2015: the main directions of development strategy until 2030 ]. 2016; 2-3.
3. Portal mjerii goroda Kazani [Portal City Hall Kazan]. www.kazan.ru
4. Tuhbatullina RG, Nagaeva AR. Vlijanie zhiznennogo cikla razvitija farmacevticheskoj organizacii chastnoj formy sobstvennosti na kachestvo okazanija lekarstvennoj pomoshhi naseleniju [The impact of the life cycle of the pharmaceutical organization of private ownership on the quality of the provision of pharmaceutical care to the population]. Trudy IX Vserossijskoj nauchno-prakticheskoj konferencii s mezhdunarodnym uchastiem «Zdorov’e-osnova chelovecheskogo potenciala: problemy i puti ih reshenija  — Sankt-Peterburg [Proceedings of IX All-Russian scientific-practical conference with international participation «Health is the basis of human development: problems and ways of their solution  — St Petersburg ]. 2014; 9: 800-802.
5. Ziganshina LE. ATS/DDD-klassifikacionnaja sistema v farmakojepidemiologicheskih issledovanijah [ATC/DDD  — classification system in pharmacoepidemiological studies]. Kachestvennaja klinicheskaja praktika [Good clinical practice]. 2004; 1: 28-33.
6. Shajdullina LJa, Ziganshina LE. Ispol’zovanie metodologii ATS/DDD dlja ocenki potreblenija lekarstvennyh sredstv i jeffektivnosti vnedrenija klinicheskih rekomendacij v stacionare [Using ATC / DDD methodology for assessing drug consumption and the efficiency of the implementation of clinical guidelines in hospital]. Zdravoohranenie [Health]. 2013; 11: 2-5.
7. Hohlov AL, Spasskij AA, Kurochkina ON. Rol’ ATS/DDD metodologii v optimizacii lechenija bol’nyh s ostrym koronarnym sindromom [The role of the ATC / DDD methodology to optimize the treatment of patients with acute coronary syndrome]. Arhiv vnutrennej mediciny [Archives of Internal Medicine]. 2013; 4 (9): 33-39.
8. O.N.Smuseva, O.V.Shatalova, Ju.V.Solovkina. Analiz potreblenija lekarstvennyh sredstv pri lechenii stenokardii [Analysis of the consumption of medicines for the treatment of angina]. Sibirskij medicinskij zhurnal [Siberian Medical Journal]. 2012; 27 (4): 79-82
9. Luneva JuV, Bezuglova EI, Filippenko NG, Povetkin SV. Sravnitel’naja harakteristika struktury naznachenija i realizacii lekarstvennyh sredstv u bol’nyh s sochetannoj kardial’noj patologiej [Comparative characteristics of the purpose of the structure and distribution of medicinal products in patients with concomitant cardiac pathology]. Kurskij nauchno-prakticheskij vestnik «Chelovek i ego zdorov’e» [Kursk scientific-practical herald «Human and his health»]. 2013; 4: 92-95.

 

UDC 616-008.9-057:669(571.17)

DOI: 10.20969/VSKM.2017.10(1).78-82

PDF downloadTHE PREVALENCE OF METABOLIC SYNDROME COMPONENTS IN METALLURGICAL ENTERPRISE WORKERS

CHIGISOVA ANTONINA N., junior research worker of the Laboratory of epidemiology of cardiovascular disease of Research Institute of cardiovascular diseases complex problems, Russia, 650002, Kemerovo, Sosnoviy ave., 6, tel. 8-960-916-40-93, e-mail: chigan@kemcardio.ru

OGARKOV MIKHAIL YU., D. Med. Sci., professor, Head of the Department of cardiology of Novokuznetsk State Physician’s Continuing Education Institute, Russia, 654095, Novokuznetsk, Stroitely ave., 5, Head of the Laboratory of epidemiology of cardiovascular disease of Research Institute of cardiovascular diseases complex problems, Russia, 650002, Kemerovo, Sosnoviy ave., 6, tel. 8-905-900-93-80, e-mail: ogarmu@kemcardio.ru

Abstract. Aim. The purpose of research is to investigate the prevalence of metabolic syndrome and its components in workers of metallurgical enterprise. Material and methods. A total of 1285 metallurgical plant workers were divided into 6 groups according to the nature of the work. Examination, survey (age, sex and risk factors), blood pressure and waist circumference measurement was performed. Blood biochemical parameters were determined for hyperglycemia and lipid metabolism disorders detection. Metabolic syndrome was diagnosed on the basis of results obtained. Statistical analysis was performed using the program Statistica 8.0. Results and discussion. The prevalence of metabolic syndrome among metallurgical plant workers was: abdominal obesity occurred in 40,47% of the employees, hypertension  — in 45,53%, dyslipidemia  — in 54,36%, hyperglycemia  — in 14,37% of the persons. The workers were characterized by the low prevalence of metabolic syndrome (13,68%) compared to the unorganized ESSAY-RF population. Maximum prevalence of metabolic syndrome was found only in the group of female metallurgical equipment drivers (17,31%). Their work was characterized by the low level of physical activity and high levels of emotional stress. The most frequent clinical variant of metabolic syndrome is a combination of abdominal obesity with hypertension and dyslipidemia. Conclusion. Lower prevalence of metabolic syndrome was identified at the steel plant workers, while it was high for arterial hypertension (in women) and hypertriglyceridemia. The contribution of professional activities to the prevalence of metabolic syndrome is set only for female drivers of metallurgical machinery. The most frequent clinical variant of metabolic syndrome is a combination of abdominal obesity with hypertension and dyslipidemia.

Key words: metabolic syndrome, abdominal obesity, arterial hypertension.

For reference: Chigisova AN, Ogarkov MY. The prevalence of metabolic syndrome components in metallurgical enterprises workers. The Bulletin of Contemporary Clinical Medicine. 2017; 10 (1): 78—82. DOI: 10.20969/VSKM.2017.10(1).78-82.

References

1. Kuz’mina OJu. Kliniko-jepidemiologicheskie osobennosti metabolicheskogo sindroma u bol’nyh professional’nymi zabolevanijami [Clinical and epidemiological features of the metabolic syndrome in patients with occupational diseases]. Mezhdunarodnyj jendokrinologicheskij zhurnal [International Journal of Endocrinology]. 2011; 4 (36). http://www.mif-ua.com/archive/article/18499
2. Mychka VB, Vertkin AL, Vardaev LI et al. Proekt rekomendacij jekspertov Rossijskogo kardiologicheskogo obshhestva po diagnostike i lecheniju metabolicheskogo sindroma, Tretij peresmotr [Experts Draft recommendations of the Russian Society of Cardiology for the diagnosis and treatment of metabolic syndrome, the third revision]. 2013; 6-11. http://www.scardio.ru›content/Guidelines/projectrecomMS
3. Grinevich VB. Abdominal’noe ozhirenie: kliniko-social’nye aspekty problemy [Abdominal obesity: clinical and social aspects of the problem]. Ozhirenie i metabolism [Obesity and Metabolism]. 2012; 2: 28-29.
4. Kazyzaeva AS. Tabakokurenie i ozhirenie kak faktory riska serdechno-sosudistyh zabolevanij u zhitelej Barnaula [Tobacco smoking and obesity as risk factors for cardiovascular disease among residents of Barnaul]. Izvestija Altajskogo gosudarstvennogo universiteta [News of Altai State University]. 2013; 1 (3: 79): 31-32.
5. Maksimov SA. Professional’nye aspekty jepidemiologii izbytochnoj massy tela: sovremennye tendencii i perspektivy profilaktiki: obzor literatury [Professional aspects of the epidemiology of overweight Body: current trends and prospects for prevention: literature review]. Medicina truda i promyshlennaja jekologija [Occupational medicine and industrial ecology]. 2013; 5: 53-57.
6. Telkova IL. Professional’nye osobennosti truda i serdechno-sosudistye zabolevanija: risk razvitija i problemy profilaktiki: kliniko-jepidemiologicheskij analiz [Professional features work and cardiovascular disease: the risk of and prevention of problems: clinical and epidemiological analysis]. Sibirskij medicinskij zhurnal [Siberian Medical Journal]. 2012; 27 (1): 21-24.
7. Starodubova AV. Ozhirenie kak faktor riska serdechno-sosudistyh zabolevanij: obzor literatury [Obesity is a risk factor for cardiovascular disease: literature review]. Farmateka [Farmateka]. 2015; 17: 28-34.
8. Bojcov SA. Arterial’naja gipertonija sredi lic 25-64 let: rasprostranennost’, osvedomlennost’, lechenie i kontrol’: po materialam issledovanija JeSSE [Arterial hypertension among people aged 25-64: prevalence, awareness, treatment and control: according to studies ESSAY]. Kardiovaskuljarnaja terapija i profilaktika [Cardiovascular therapy and prevention]. 2014; 13 (4): 4-14.
9. Kondrat’eva NV. Ocenka serdechno-sosudistogo riska v hode periodicheskih medicinskih osmotrov i ego korrekcija v uslovijah mediko-sanitarnoj chasti krupnogo predprijatija [Assessment of cardiovascular risk through periodic medical examinations and its correction in the conditions of health of the large enterprise]. Moscow. 2016; 153 p.
10. Sumin AN. Vzaimosvjaz’ tipa lichnosti D i metabolicheskogo sindroma po dannym issledovanija JeSSE-RF v Kemerovskoj oblasti [The relationship type D personality and metabolic syndrome, according to research essay in the Kemerovo region of the Russian Federation]. Arterial’naja gipertenzija [Arterial hypertension]. 2016; 22 (1): 73-85.

 

HELP FOR PRACTITIONER

UDC 616-008.939.155-056.7-082

DOI: 10.20969/VSKM.2017.10(1).83-88

PDF downloadGUIDELINES ON THE MEDICAL CARE ORGANIZATION TO THE PATIENTS WITH HEREDITARY ATHEROGENIC LIPID DISORDERS IN THE REGIONS OF RUSSIA (joint project of the National society for the research on atherosclerosis and non-profit partnership «The National council of experts on rare diseases»)

SOKOLOV ALEKSEY A., D. Med. Sci., professor of the Department of nephrology and efferent therapy of S.M. Kirov Military Medical Academy, executive director of the National Board of Experts on Rare Diseases, Russia, 194044, St. Petersburg, Akademik Lebedev str., 6, lit. J, e-mail: dr.sokolov@list.ru

ALEXANDROVA OKSANA YU., D. Med. Sci., professor of the Department of the principles of legislation in health care of I.M.   Sechenov First Moscow State Medical University, Russia, 119991, Moscow, Trubetskaya str., 8, build. 2, e-mail: Aou18@mail.ru

KASHTALAP VASILIY V., D. Med. Sci., Head of the laboratory of pathophysiology of multifocal atherosclerosis of Research Institute of Cardiovascular Diseases Complex Problems, Russia, 650002, Kemerovo, Sosnoviy ave., 6, e-mail: v_kash@mail.ru

BARBARASH OLGA L., corresponding member of Russian Academy of Science, D. Med. Sci., professor, Director of Research Institute of Cardiovascular Diseases Complex Problems, Russia, 650002, Kemerovo, Sosnoviy ave., 6, e-mail: olb61@mail.ru

YEZHOV MARAT V., D. Med. Sci., professor, leading researcher of the Department of atherosclerosis of Russian Cardiology Research and Production Complex, president of the National Atherosclerosis Research Society, Russia, 121552, Moscow, 3rd Cherepkovskaya, 15a, e-mail: Marat_ezhov@mail.ru

Abstract. Cardiovascular diseases, including those caused by atherosclerosis and thrombosis, take a leading place in the structure of adult mortality of the population of economically developed countries. Aim. Guidelines are designed to demonstrate possible approaches to routing organization for the patients with hereditary atherogenic lipid disorders according to existing legal documents. Material and methods. The stages of care for this group of patients were considered in the recommendations. Results and discussion. Possible types of medical care, conditions of its provision and institutions, on the basis of which it can be performed, as well as the options of payment were considered for each stage. Detailed examination criterion was considered for the group of patients with suspected hereditary atherogenic lipid metabolism. Conclusion. The main statements of the guidelines on the organization of medical care to patients with hereditary atherogenic lipid disorders in the Russian regions presented are intended for health managers, head physicians, cardiologists, internists and other physicians.

Key words: patient routing, inherited atherogenic lipid disorders, procedures and types of medical care.

For reference: Sokolov AA, Alexandrova OYu, Kashtalap VV, Barbarash OL, Yezhov MV. Guidelines on the medical care organization to the patients with hereditary atherogenic lipid disorders in the Regions of Russia (Joint project of the national society for the research on atherosclerosis and non-profit partnership @The national council of experts on rare diseases@). The Bulletin of Contemporary Clinical Medicine. 2017; 10 (1): 83—88. DOI: 10.20969/VSKM.2017.10(1).

 

PRACTICAL EXPERIENCE

UDC 616.24-002.5-07

DOI: 10.20969/VSKM.2017.10(1).89-93

PDF downloadPROBLEM OF TUBERCULOUS DETECTION IN PULMONOLOGIST’S PRACTICE

BORODULINA ELENA A., D. Med. Sci, professor, Head of the Department of phthisiology and pulmonology of Samara State Medical University, Russia, 443099, Samara, Pionerskaya str., 48, tel. 8-846-332-57-35, e-mail: Borodulinbe@ yandex.ru

POVALYAEVA LYUDMILA V., C. Med. Sci, deputy Head physicion of Samara City Hospital № 4, associate professor of the Department of phthisiology and pulmonology of Samara State Medical University, Russia, 443056, Samara, Michurin str., 125, tel. 8-846-312-55-18

BORODULINA ELVIRA V., postgraduate student of the Department of public health and health management with economics course of Samara State Medical University, pulmonologist of Samara City Hospital № 4, Russia, 443056, Samara, Michurin str., 125, tel. +7-846-312-55-10

VDOUSHKINA ELIZAVETA S., postgraduate student of the Department of phthisiology and pulmonology of Samara State Medical University, pulmonologist of Samara City Hospital № 4, Russia, 443056, Samara, Michurin str., 125, tel.+7-846-312-55-10

BORODULIN BORIS E., D. Med. Sci, professor of the Department of phthisiology and pulmonology of Samara State Medical University, Russia, 443099, Samara, Pionerskaya str., 48

Abstract. Diagnosis of tuberculosis is an important problem in general health care. Pulmonologists deal with this problem more often. Aim. To indicate the importance of the problem of differential diagnosis at present using clinical case of pulmonary tuberculosis detection in patient with destructive pneumonia with a background of 3 month non-specific treatment (ABT broad-spectrum). Initial screening usually does not allow detecting tuberculosis. Respiratory fluoroquinolones and broad-spectrum antibiotics prescribed for pneumonia can often imply masking tuberculosis clinic. Material and methods. Clinical observation. Results and discussion. In the clinical example the infiltration has decreased turning into tuberculosis cavity formation as a result of long-term treatment in different hospitals. This case is considered to be an example of late untimely tuberculosis detection. Finger pointing does not help; a new approach to potential tuberculosis patient stratification is needed. Conclusion. Creating diagnostic departments and 0-B group medical follow-up extension will imply better diagnostics.

Key words: pneumonia, cavernous tuberculosis, diagnostics, diabetes, Diaskintest, radiography, CT, direct microscopic study for Mycobacterium tuberculosis

For reference: Bоrоdulinа EA, Povalyaeva LV, Borodulina EV, Vdoushkina ES, Borodulin BE. Problem of tuberculous detection in pulmonologist’s practice. The Bulletin of Contemporary Clinical Medicine. 2017; 10 (1): 89—93. DOI: 10.20969/VSKM.2017.10(1).89-93.

References

1. Vizel AA, Lyisenko GV. Pnevmoniya: k voprosu diagnostiki i lecheniya v sovremennyih usloviyah [Pneumonia: the question of diagnosis and treatment in modern conditions]. Prakticheskaya meditsina [Preserving Medicine]. 2012; 1 (56): 22-25.
2. Deykina ON, Mishin VYu, Malyavin AG. Problemyi differentsialnoy diagnostiki vnebolnichnoy pnevmonii i tuberkuleza legkih v obschesomaticheskom statsionare [Problems of differential diagnosis of community-acquiredpneumonia and pulmonary tuberculosis in somatic hospital]. Tuberkulez i bolezni legkih [Tuberculosis and Lung Disease]. 2011; 88 (4): 122-123.
3. Belova IB, Sotnikova TA. Differentsialnaya diagnostika oslozhnennoy pnevmonii, tuberkuleza legkih, raka legkih [Differential diagnosis of complicated pneumonia, pulmonary tuberculosis, lung cancer]. Uchenyie zapiski Orlovskogo gosudarstvennogo universiteta; seriya: estestvennyie, tehnicheskie i meditsinskie nauki [Scientific notes of Oryol State University; series: natural, technical and medical sciences]. 2015; 4: 292-299.
4. Borodulina EA, Borodulin BE, Povalyaeva LV, Viktor NN, Kalinkin AV, Amosova EA, Huzhin NA. Differentsialnaya diagnostika vnebolnichnoy pnevmonii i infiltrativnogo tuberkuleza legkih diaskintestom [Differential diagnosis of community-acquired pneumonia and infiltrative pulmonary tuberculosis Diaskintest]. Pulmonologiya [Pulmonology]. 2010; 3: 89-91.
5. Lishmanov YuB, Krivonogov NG, Ageeva TS. K voprosu o luchevoy differentsirovke sindromoshodnoy patologii legkih: vozmozhnosti ispolzovaniya ventilyatsionno-perfuzionnoy pulmonostsintigrafii [On the question of radiation differentiation sindromoskhodnoy lung diseases: the possibility of using the ventilation-perfusion lung scintigraphy]. Luchevaya diagnostika i terapiya [Radiation diagnostics and therapy]. 2010; 2: 4-11.