Vol. 13 Issue 3 (2020)

VSKM 2020 N 3

PDF download Download the whole Issue

ORIGINAL RESEARCH

Early complications of gastrectomy with single-row esophagoenteroanastomosis.Akhmetzyanov F.Sh. (Russia, Kazan), Gaynanshin R.R. (Russia, Kazan), Akhmetzyanova F.F. (Russia, Kazan), Zubkova A.R. (Russia, Kazan),
Baltaeva D.A. (Russia, Kazan), Khan A.M. (Russia, Kazan) P. 7

Study of the relationship between the chronization of post-infection glomerulonephritis and peripheral blood monocyte activity. Kudryashov S.I. (Russia, Cheboksary), Karzakova L.M. (Russia, Cheboksary), Zhuravleva N.V. (Russia, Cheboksary), Ukhterova N.D. (Russia, Cheboksary) P. 15

Hyper-sensitivity pneumonia combined with coronary heart disease: clinical, radiological, and functional features. Medvedev A.V. (Russia, Moscow), Abubikirov A.F. (Russia, Moscow), Zaitseva A.S. (Russia, Moscow), Mazaeva L.A. (Russia, Moscow), Makaryants N.N. (Russia, Moscow), Shmelev E.I. (Russia, Moscow), Shmeleva N.M. (Russia, Moscow) P. 20

Integrated analysis of surgical methods of pulmonary embolism prevention. Fedorov S.A. (Russia, Nizhny Novgorod),Medvedev A. P., (Russia, Nizhny Novgorod),Maximov A.L. (Russia, Nizhny Novgorod),Abdulyanov I.V. (Russia, Kazan), Zhurko S.A. (Russia, Nizhny Novgorod), Tselousova L.M. (Russia, Nizhny Novgorod), Trofimov N.A. (Russia, Cheboksary), Mironov E.A. (Russia, Nizhny Novgorod) P. 28

Experience of (olodaterol/tiotropium bromide-respimat) combination bronchodilator application in patients with respiratory tuberculosis combined with chronic obstructive pulmonary disease. Khanin A.L. (Russia, Novokuznetsk), Kravets S.L. (Russia, Prokop’evsk) P. 35

REVIEWS

Myocardial scintigraphy and coronary angiography capabilities in the diagnosis of coronary artery lesions in painless myocardial ischemia. Abdrakhmanova A.I. (Russia, Kazan), Tsibulkin N.A. (Russia, Kazan), Amirov N.B. (Russia, Kazan) P. 41

The importance of cardio rehabilitation combined with psychological correction for post miocaridal infarction patients. Zhitkova R.S. (Russia, Kazan), Khaliullina D.R. (Russia, Kazan), Akhmetshina L.A. (Russia, Kazan), Sharipova R.R. P. 47

Modern antiseptics in surgical area manipulation. Morozov A.M. (Russia, Tver), Sergeev A.N.(Russia, Tver), Kadykov V.A. (Russia, Tver), Askerov E.M. (Russia, Tver), Zhukov S.V. (Russia, Tver), Peltikhina O.V., (Russia, Tver), Pichugova A.N.(Russia, Tver) P. 52

Inhaled glucocorticosteroids and chronic obstructive pulmonary disease: a review of the concept.Khamitov R.F. (Russia, Kazan), Vizel A.A. (Russia, Kazan), Zhestkov A.V. (Russia, Samara), Bogdanova Ju.V. (Russia, Samara), Galushina I. A. (Russia, Ul’yanovsk), Zvereva E.V. (Russia, Kirov), Zulkarneev R.Kh. (Russia, Ufa), Kulbaisov A.M. (Russia, Orenburg), Mishlanov V. Yu. (Russia, Perm), Pavlov P.I. (Russia, Cheboksary), Sushentsov V.G. (Russia, Izhevsk), Starodubtseva O.I. (Russia, Samara), Steshenko R.N. (Russia, Saratov), Fedotov V.D. (Russia, Nizhny Novgorod) P. 59

Radiation-induced lung injury. A review. Shaymuratov R.I. (Russia, Kazan) P. 64

Key elements of electronic health information system in the Russian Federation (review and analysis of research articles). Shubin I.V. (Russia, Krasnogorsk), Mishlanov V.Yu. (Russia, Perm) P. 74

PRACTICAL EXPERIENCE

Causes of unfavorable outcomes in emergency surgery. Krasilnikov D.M. (Russia, Kazan), Mirgasimova Dz.M. (Russia, Kazan), Abdulyanov A.V. (Russia, Kazan), Zefirov R.A. (Russia, Kazan), Zakharova A.V. (Russia, Kazan), Semenova I.I. (Russia, Kazan) P. 81 

EXPERIMENTAL STUDIES – TO CLINICAL MEDICINE

The influence of major surgery on rat cognitive functions.Sharipova V.Kh. (Uzbekistan, Tashkent), Valikhanov A. A.(Uzbekistan, Tashkent), Alimov A.Hk. (Uzbekistan, Tashkent), Abdullaev J.G. (Uzbekistan,  Tashkent) P. 86

___

ORIGINAL RESEARCH

UDC 616.33-089.87-06

DOI: 10.20969/VSKM.2020.13(3).7-14

PDF download EARLY COMPLICATIONS OF GASTRECTOMY WITH SINGLE-ROW ESOPHAGOENTEROANASTOMOSIS

AKHMETZYANOV FOAT SH., D. Med. Sci., professor, Head of the Department of oncology, radiation diagnostics and radiation therapy of Kazan State Medical University, 420012, Kazan, Butlerov str., 49, tel. 8-917-254-50-86, e-mail: akhmetzyanov@mail.ru

GAYNANSHIN RAMIL R., ORCID ID: 0000-0001-9415-4251; postgraduate student of the Department of oncology, radiation diagnostics and radiation therapy of Kazan State Medical University, 420012, Kazan, Butlerov str., 49, tel. 8-987-008-55-17, e-mail: gaynanshin90@gmail.com.

AKHMETZYANOVA FARIDA F., assistant of professor of the Department of oncology, radiation diagnostics and radiation therapy of Kazan State Medical University, 420012, Kazan, Butlerov str., 49

ZUBKOVA ALINA R., resident of the Department of oncology, radiation diagnostics and radiation therapy of Kazan State Medical University, 420012, Kazan, Butlerov str., 49

BALTAEVA DINARA A., ORCID ID: 0000-0003-2736-3939; postgraduate student of the Department of oncology, radiation diagnostics and radiation therapy of Kazan State Medical University, 420012, Kazan, Butlerov str., 49

KHAN AMIRKHAN M., ORCID ID: 0000-0001-6614-5550; postgraduate student of the Department of oncology, radiation diagnostics and radiation therapy of Kazan State Medical University, 420012, Kazan, Butlerov str., 49

Abstract. The gold standard in the treatment of gastric cancer is surgical, and the most common type of surgical intervention is gastrectomy with extended lymphodysection D2. Gastrectomy is the most dif cult operation from the technical point of view, because besides the abdominal cavity, the surgical eld includes mediastinum. Due to these circumstances, there are serious complications in the early post-operative period, which are harmful to health or often lead to the death of the patient. Aim. To analyze the frequency and structure of early postoperative complications in patientswith gastric cancer who underwent gastrectomy in diagnostic and treatment unit No 2 at the Republican Clinical Oncologic Dispensary of the Ministry of Health of the RT with a single-row original esophagogue-anastomosis based on Gilarovich’s method, in comparison with the literature data, among those operated according to the similar method, but with a doublerow anastomosis. Material and methods. Retrospective analysis of early postoperative complications in 127 patients who underwent gastrosplenectomy with enlarged D2 lymphodysection by single-row esophagogoenteroanastomosis using an original technique developed in our clinic on the basis of Gilarovic-Sigal techniques. There were 29 patients under 60 years of age (22,8%) and 98 (77,2%) patients over 60. The mean age was 63,8 years. It should be noted that 61 (48,0%) were over 70 years old and 20 (15,7%) were over 80 years old. According to the 7th edition of the IUCS classi cation, the patients were distributed as follows: stage 1–16 (12,6%), stage 2–19 (15,0%), stage 3–70 (55,1%), stage 4–22 (17,3%) persons. Results and discussion. We divide early postoperative complications into intra- and extra-abdominal. Extraabdominal complications prevailed in our observations. In comparison with the literature data, the incidence of intra-abdominal complications was 2 and more times lower, while the incidence of extra-abdominal complications mainly corresponded to the global statistics. Conclusions. The results of our study show the importanceof choosing the right technique for applying anastomosis. The method developed in our clinic allows to signi cantly reduce both the number of complications and early postoperative mortality.

Key words: gastric cancer, gastrectomy, splenectomy, lymphadenectomy, single-row anastomosis, early postoperative complications.

For reference: Akhmetzyanov FSh, Gainanshin RR, Akhmetzyanova FF, Zubkova AR, Baltaeva DA, Khan AM. Early complications of gastrectomy with single-row esophagoenteroanastomosis. The Bulletin of Contemporary Clinical Medicine. 2020; 13 (3): 7-14. DOI: 10.20969/VSKM.2020.13(2).7-14.

References

1. Shalimov AA, Polupan VN. Atlas operacij na pishchevode, zheludke i dvenadcatiperstnoj kishke [Atlas of operations on the esophagus, stomach and duodenum]. Moskva: Izdatelstvo Medicina [Moscow: Publishing House Medicine]. 1975; 68-78.

2. Cozzaglio L, Coladonato M, Bif R, et al. Duodenal stula after elective gastrectomy for malignant disease: an italian retrospective multicenter study. J Gastrointest Surg. 2010; 14 (5): 805-811.

3. Chernousov AF, Horobryh TV, Vychuzhanin DV. Rezultaty hirurgicheskogo lecheniya pacientov s kardio-ezofagealnym rakom [Results of surgical treatment of patients with gastroesophageal cancer]. Sechenovskij vestnik [Sechenovsky Bulletin]. 2011; 1: 36-40.

4. Danielson H, Kokkola A, Kiviluoto T, et al. Clinical outcome after dl vs D 2-3 gastrectomy for treatment of gastric cancer. Scandinavian Journal of Surgery. 2007; 96: 35-40.

5. Chernousov AF, Horobryh TV, Vychuzhanin DV, Rogal MM. Hirurgicheskoe lechenie mestno-rasprostranennogo raka zheludka [Surgical treatment of locally advanced gastric cancer]. Vestnik-hirurgicheskoj gastroenterologii [Bulletin of Surgical Gastroenterology]. 2010; 5: 4-10.

6. Fernández A, Vila JJ, Vázquez S, et al. Self-expanding plastic stents for the treatment of post-operative esophago-jejuno anastomosis leak: A case series study. Rev Esp Enferm Dig. 2010; 102 (12): 704-710.

7. Volkov SV. Vybor metoda formirovaniya pishchevodno-kishechnogo anastomoza posle gastrektomii [The choice of the method of formation of the esophageal-intestinal anastomosis after gastrectomy]. Vestnik Chuvashskogo universiteta [Bulletin of the Chuvash University]. 2012; 3: 370-374.

8. Hvastunov RA, Misharev SP. Kombinirovannyye operatsii pri rake zheludka [Combined operations for gastric cancer]. Barnaul: Tezisy mezhdunarodnoy nauchno-prakticheskoy konferentsii 20-21 iyulya «Izbrannyye voprosy onkologii», v knige «Izbrannyye voprosy onkologii» [Barnaul: Abstracts of the international scienti c-practical conference on July 20-21, “Selected issues of oncology”, in the book “Selected issues of oncology”]. 1999; 351-352.

9. Ahmetzyanov FSh, Borisov VP, Ahmetzyanova FF. Originalnyj metod ezofagoeyunoanastomoza pri gastrektomii po povodu raka zheludka v pro laktike posleoperacionnyh oslozhnenij [The original method of esophagoguejunoanastomosis for gastrectomy for gastric cancer in the prevention of postoperative complications]. Kazanskij medicinskij zhurnal [Kazan medical journal]. 2014; 95 (4): 505-510.

10. Chernousov FA, Guchakov RV. Sravnitelnaya ocenka sposobov formirovaniya ezofagoeyunalnogo anastomoza pri gastrektomii [Comparative evaluation of methods for the formation of esophageojunoanastomosis in gastrectomy]. Moskva: Tezisy nauchno-prakticheskoy konferentsii «Vosstanovitelnye i organosberegayushchie tekhnologii – glavnyj put razvitiya hirurgii XXI veka» [Moscow: Abstracts of the international scienti c-practical conference [Restoration and organ-saving technologies – the main path of development of surgery of the 21st century]. 2004; 131.

11. Isgiider AS, Nazli O, Tansug T, et al. Total gastrectomy for gastric carcinoma. Hepatogastroenterology. 2005; 52: 302-304.

12. Portanova M. Successful enteral nutrition in the treatment of esophagojejunal stula after total gastrectomy in gastric cancer patients. World Journal of Surgical Oncology. 2010; 8: 71.

13. Slugarev VV, Gamayunov CB, Denisenko AN, et al. Opyt uspeshnogo lecheniya nedostatochnosti pishchevodno-kishechnogo anastomoza posle gastrektomii pishchevodnym stentom ELLA [Experience of successful treatment of insuf ciency of the esophageal-intestinal anastomosis after gastrectomy with an esophageal stent ELLA]. Nablyudeniya iz praktiki [Practice observations]. 2010; 4: 142-145.

14. Chernousov AF, Polikarpov SA, CHernousov FA. Hirurgiya raka zheludka [Stomach cancer surgery]. Moskva: IZDat [Moscow: Publishing House «IZDat»]. 2004; 316 p.

15. Chkhikvadze VD, Sdvizhkov AM, Makarova ЕE. Risk hirurgicheskogo lecheniya pozhilyh i staryh bolnyh rakom
zheludka [The risk of surgical treatment of elderly and old patients with gastric cancer]. Klinicheskaya gerontologiya [Сlinical gerontology]. 2005; 11: 33—377.

16. Еgorov VI, Turusov PA, Schastlivcev IV, Baranov AO. Kishechnye anastomozy; Fiziko-mekhanicheskiye aspekty [Intestinal anastomoses; Physical and mechanical aspects]. Moskva: Vidar [Moscow: Publishing House Vidar]. 2004; 304 p.

17. Chernousov AF, Horobryh TV, Antonov ON. Pro laktika nedostatochnosti anastomozov zheludochno-kishechnogo trakta [Prevention of gastrointestinal anastomosis insufficiency]. Hirurgiya Zhurnal imeni NI Pirogova [Surgery; Pirogov magazine]. 2005; 12: 25-29.

18. Davydov MI, Stilidi IS, Itin AB, et al. Vozmozhnosti hirurgicheskogo lecheniya bolnyh rakom zheludka starcheskogo vozrasta [Surgical treatment options for senile gastric cancer patients]. Klinicheskaya gerontologiya [Klinical gerontology]. 2005; 6: 31—37.

19. Bonenkamp JJ, Hermans J, Sasako M, et al. Dutch Gastric Cancer Group; Extended lymph-node dissection for gastric cancer. N Engl J Med. 1999; 340: 908-914.

20. Katai H, Yoshimura K, Fukagawa T, et al. Risk factors for pancreas related abscess after total gastrectomy. Gastric; Cancer. 2005; 8 (3): 137-141.

21. Nobuoka D, Gotohda N, Konishi M, et al. Prevention of postoperative pancreatic stula after total gastrectomy. World J Surg. 2008; 32 (10): 2261-2266.

22. Dzhuraev MD, Egamberdiev DM, Mirzaraimova SS, Hudojberdieva MSh. Rezultaty hirurgicheskogo lecheniya pri mestnorasprostranennom rake zheludka [Results of surgical treatment for locally advanced gastric cancer]. Onkologiya [Oncology]. 2008; 106 (4): 406-409.

23. Ahmetzyanov FSh, Ruvinskij DM. Gastrosplenektomii po povodu raka zheludka [Gastrectomy for stomach cancer]. Еvrazijskij onkologicheskij zhurnal [Eurasian oncology journal]. 2014; 3 (3): 420-421.

24. Turkin IN, Davydov MM, Davydov MI. Vliyaet li splenektomiya pri rake zheludka na chastotu razvitiya pankreatogennyh oslozhnenij? [Does splenectomy in gastric cancer affect the incidence of pancreatogenic complications]. Vestnik RONC imeni Blohina [Bulletin of the Russian Oncology Research Center them Blohin]. 2013; 24 (1): 31-34.

25. Davydov MI, Turkin IN, Davydov MM. Enciklopediya hirurgii raka zheludka [Encyclopedia of gastric cancer surgery]. Moskva: ID EKSMO [Moscow: Publishing House EKSMO]. 2011; 536 p.

26. Brekhov ЕI, Kalinnikov VV, Safarov AN. Intraoperacionnye travmy podzheludochnoj zhelezy i lechenie ih posledstvij [Pancreatic intraoperative injuries and treatment of their consequences]. Annaly hirurgicheskoj gepatologii [Annals of surgical hepatology]. 2004; 2: 172.

27. Kriger AG, Karmazanovskij GG, Gorin DS. Neposredstvennye i otdalennye rezultaty lecheniya solidno-psevdopapillyarnyh opuholej podzheludochnoj zhelezy [Immediate and long-term results of treatment of solidpseudopapillary pancreatic tumors]. Hirurgiya imeni NI Pirogova [Pirogov surgery]. 2012; 1: 19-24.

28. Kubyshkin VA, Kriger AG, Svitina KA. Posleoperacionnyj pankreatit pri hirurgicheskih vmeshatelstvah na podzheludochnoj zheleze [Postoperative pancreatitis in pancreatic surgery]. Hirurgiya imeni NI Pirogova [Pirogov surgery]. 2012; 4: 14-19.

29. Kriger AG, Kozlov IA, Svitina KA, Kochatkov AB. Ostryj posleoperacionnyj pankreatit u bolnyh, operirovannyh na podzheludochnoj zheleze [Acute postoperative pancreatitis in patients operated on the pancreas]. Moskva: Materialy IV Kongressa Moskovskih hirurgov «Neotlozhnaya i specializirovannaya hirurgicheskaya pomoshch» [Moscow: Materials of the congress of Moscow surgeons «Emergency and specialized surgical care»]. 2011; 201-202.

30. Svitina KA, Berelavichus CB, Gorin DS. Ostryy posleoperatsionnyy pankreatit posle vmeshatel’stv na podzheludochnoy zheleze [Acute postoperative pancreatitis after interventions on the pancreas]. Moskva: Materialy XVIII Mezhdunarodnogo Kongressa khirurgov-gepatologov Rossii i stran SNG «Aktual’nyye problemy khirurgicheskoy gepatologii» [Moscow: Materials of the XVIII International Congress of Surgeons-Hepatologists of Russia and the CIS “Actual Problems of Surgical Hepatology”]. 2011; 379.

31. Li J, Wang R, Tang C. Somatostatin and octreotide on the treatment of acute pancreatitis – basic and clinical studies for three decades. Current pharmaceutical design. 2011; 17: 1594-1601.

32. Nemeth AM. Somatostatin in the treatment of pancreatic diseases. Orvosi hetilap. 2002; 9: 1099-1108.

33. Poon RT, Fan ST. Antisecretory agents for prevention of post-ERCP pancreatitis: rationale for use and clinical results. Journal of pancreas. 2003; 4 (1): 33-40.

34. Sigal MZ, Ahmetzyanov FSh. Gastrektomiya i rezekciya zheludka po povodu raka; II izdanie [Gastrectomy and gastrectomy for cancer; 2nd edition]. Kazan: Tatarskoe knizhnoe izatelstvo [Kazan: Tatar Publishing House]. 1991; 360 p.

35. Ahmetzyanov FSh. Puti resheniya problemi hirurgicheskogo lecheniya raka sheludka [Ways to solve the problem of surgical treatment of gastric cancer]. Kazanskij medicinskij zhurnal [Kazan medical journal]. 2017; 98 (4): 485-491.

 

UDC 616.611-002-07:616.155.33-07

DOI: 10.20969/VSKM.2020.13(3).14-19

PDF download STUDY OF THE RELATIONSHIP BETWEEN THE CHRONIZATION OF POST-INFECTION GLOMERULONEPHRITIS AND PERIPHERAL BLOOD MONOCYTE ACTIVITY

KUDRYASHOV SERGEY I., ORCID ID: 0000-0003-2277-9425; C. Med. Sci., assistant of professor of the Department of internal medicine of Chuvash State University named after I.N. Ulyanov, Russia, 428015, Cheboksary, Moskovskii' ave., 15, tel. 8-917-652-34-99, e-mail: medicpro21@mail.ru

KARZAKOVA LOUISA M., ORCID ID: 0000-0002-5899-6352; SCOPUS Author ID: 56916027300; D. Med. Sci., professor, the Head of the Department of internal medicine of Chuvash State University named after I.N. Ulyanov, Russia, 428015, Cheboksary, Moskovskii' ave., 15, tel. 8-903-358-82-89, e-mail: luizak58@mail.ru

ZHURAVLEVA NADEZHDA V., ORCID ID: 0000-0001-6470-7724; C. Med. Sci., associate professor of the Department of internal medicine of Chuvash State University named after I.N. Ulyanov, Russia, 428015, Cheboksary, Moskovskii' ave., 15, tel. 8-903-358-71-78, e-mail: zhuravlevanv@mail.ru

UKHTEROVA NADEZHDA D., ORCID ID: 0000-0003-1808-6845; C. Med. Sci., associate professor of the Department of internal medicine of Chuvash State University named after I.N. Ulyanov, Russia, 428015, Cheboksary, Moskovskii' ave., 15, tel. 8-906-136-73-41, e-mail: 55dd@mail.ru

Abstract. Aim. The aim of the study was to study the relationship between the chronization of post-infection glomerulonephritis (PIGN) and peripheral blood monocyte activity indices such as the level of IL-1β, RAIL-1β cytokines circulating in blood and the levels of TLR2 and TLR4 Toll-like receptor expression. Material and methods. The clinicalstudy enrolled patients in the debut of post-infection glomerulonephritis who were hospitalized at the nephrological department of Republican Clinical Hospital of the Ministry of Health of Chuvash Republic in 2013–2018. Post-infection glomerulonephritis was diagnosed upon detection of three of the following symptoms: 1) clinical or laboratory signs of a prior glomerulonephritis infection or the presence of infection during the development of glomerulonephritis; 2) diffuse endocapillary proliferative/exudative glomerulonephritis; 3) decrease in the C3 and/or C4 complement component serum content; 4) C3 deposition in renal tubules with or without immune complexes; 5) detection of hump-like subepithelial formations at the site of immune complexes deposits by electron microscopy. Study protocol: in addition to the commonly used methods, the patients were examined before the prescription of pathogenetic treatment on the 1st and 2nd days of inpatient treatment by taking blood to determine the expression of TLR2, TLR4 on peripheral blood monocytes and to determine the content of IL-1β and RAIL-1β cytokines circulating in the blood. The expression of TLR2, TLR4 on monocytes was determined by ow cytometry using CD282 and CD284 monoclonal antibodies. Serum IL-1β and RAIL-1β levels were determined by immunoassay. After one year of observation, the nature of clinical course of the disease (acute or chronic post-infection glomerulonephritis) was determined and the patients were sampled into two groups, achieving the equation of patient groups by gender and age composition, representation of different clinical and morphological types of glomerulonephritis. The control group was a cohort of healthy individuals, comparable in demographic terms to the groups of patients. Non-parametric methods of statistical analysis were used for statistical processing of the study results. Reliability of differences in relative values was assessed using the χ2 criterion. Results and discussion. Differences in TLR2, TLR4 expression levels on monocytes and serum content of IL-1β and RAIL-1β cytokines in patients depending on the nature of the clinical course of post-infection glomerulonephritis were found in the debut of post-infection glomerulonephritis: The patients with acute post-infection glomerulonephritis had higher levels of IL-1β and RAIL-1β production and TLR2-, TLR4-positive monocyte count as compared to the group of patients with chronic course of postinfection glomerulonephritis. Conclusion. Insuf cient activation of monocytes in the debut of post-infection glomerulonephritis causes the chronization of this disease.

Key words: post-infectious glomerulonephritis, chronization of glomerulonephritis, innate immunity.

For reference: Kudryashov SI, Karzakova LM, Zhuravleva NV, Ukhterova ND. Study of the relationship between the chronization of post-infection glomerulonephritis and peripheral blood monocyte activity. The Bulletin of Contemporary Clinical Medicine. 2020; 13 (3): 14-19. DOI: 10.20969/VSKM.2020.13(3).14-19.

References

  1. Bright R. Cases and Observations Illustrative of Renal Disease Accompanied with the Secretion of Albuminous Urine. Guy’s Hospital Reports. 1836; 1: 388-400.

  2. Balasubramanian R, Marks SD. Post-infectious glomerulonephritis. Paediatr Int Child Health. 2017; 37 (4): 240–247.

  3. Wang SY, Bu R, Zhang Q, et al. Clinical, Pathological, and Prognostic Characteristics of Glomerulonephritis Related to Staphylococcal Infection. Medicine (Baltimore). 2016; 95 (15): e3386.

  4. Toubi E, Vadasz Z. Innate immune-responses and their role in driving autoimmunity. Autoimmun Rev. 2019; 18 (3): 306–311.

  5. Anders HJ. Of in ammasomes and alarmins: IL-1β and IL-1α in kidney disease. J Am Soc Nephrol. 2016; 27: 2564–2575.

  6. Weidenbusch M, Kulkarni OP, Anders HJ. The innate immune system in human systemic lupus erythematosus. Clin Sci (Lond). 2017; 131(8): 625–634.

  7. Borthwick LA. The IL-1 cytokine family and its role in in ammation and brosis in the lung. Semin. Immunopathol. 2016; 38 (4): 517–534.

  8. Gabay C, Lamacchia C, Palmer G. IL-1 pathways in in ammation and human diseases. Nat Rev Rheumatol. 2010; 6 (4): 232–241.

  9. Usui J, Tawara-Iida T, Takada T, et al. Temporal Changes in Post-Infectious Glomerulonephritis in Japan (1976-2009). PLoS One. 2016; 11 (6): e0157356.

  10. Leaf IA, Nakagawa S, Johnson BG, et al. Pericyte MyD88 and IRAK4 control in ammatory and brotic responses to tissue injury. J Clin Invest. 2017; 127: 321–334.

  11. Vasse M, Paysant I, Soria J, et al. Down-regulation of brinogen biosynthesis by IL-4, IL-10 and IL-13. Br J Haematol. 1996; 93 (4): 955–961.

  12. Duf eld JS. Cellular and molecular mechanisms in kidney brosis. J Clin Invest. 2014; 124: 2299–2306.

  13. Elloumi N, Fakhfakh R, Abida O, et al. Relevant genetic polymorphisms and kidney expression of Toll-like receptor (TLR)-5 and TLR-9 in lupus nephritis. Clin Exp Immunol. 2017; 190 (3): 328–339.

  14. Tizaoui K, Naouali A, Kaabachi W, et al. Association of Toll like receptor Asp299Gly with rheumatoid arthritis risk: a systematic review of case-control studies and meta-analysis. Pathol Res Pract. 2015; 211 (3): 219–225.

  15. Valverde-Villegas JM, Dos Santos BP, de Medeiros RM, et al. Endosomal toll-like receptor gene polymorphisms and susceptibility to HIV and HCV co-infection – Differential in uence in individuals with distinct ethnic background. Hum Immunol. 2017; 78 (2): 221–226.

 

UDC 616.24-002-056.3:616.12-005.4

DOI: 10.20969/VSKM.2020.13(3).19-27

PDF download HYPER-SENSITIVITY PNEUMONIA COMBINED WITH CORONARY HEART DISEASE: CLINICAL, RADIOLOGICAL, AND FUNCTIONAL FEATURES

MEDVEDEV ALEXANDER V., C. Med. Sci., senior researcher of the Department of tuberculosis differential diagnosis and extracorporeal methods of treatment of Central Tuberculosis Research Institute, Russia, 107564, Moscow, Yauzskaya alley, 2, tel. +7-499-785-90-31, e-mail: alexmedved_1@mail.ru

ABUBIKIROV ANVER F., C. Med. Sci., senior researcher of the Department of tuberculosis differential diagnosis and extracorporeal methods of treatment of Central Tuberculosis Research Institute, Russia, 107564, Moscow, Yauzskaya alley, 2, tel. +7-499-785-90-31, e-mail: abubik_1@mail.ru

ZAITSEVA ANNA S., C. Med. Sci., senior researcher of the Department of tuberculosis differential diagnosis and extracorporeal methods of treatment of Central Tuberculosis Research Institute, Russia, 107564, Moscow, Yauzskaya alley, 2, tel. +7-499-785-90-31, e-mail: anyasyls@yandex.ru

MAZAEVA LARISA A., C. Med. Sci., researcher of the Department of tuberculosis differential diagnosis and extracorporeal methods of treatment of Central Tuberculosis Research Institute, Russia, 107564, Moscow, Yauzskaya alley, 2, tel. +7-499-785-90-31, e-mail: lara.mazaeva@yandex.ru

MAKARYANTS NATALIA N., D. Med. Sci., leading researcher of the Department of tuberculosis differential diagnosis and extracorporeal methods of treatment of Central Tuberculosis Research Institute, 107564, Russia, Moscow, Yauzskaya alley, 2, tel. +7-499-785-90-31, e-mail: Roman4000@yandex.ru

SHMELEV EVGENY I., D. Med. Sci., the Head of the Department of tuberculosis differential diagnosis and extracorporeal methods of treatment of Central Tuberculosis Research Institute, Russia, 107564, Moscow, Yauzskaya alley, 2, tel. +7-499-785-90-08, e-mail: eishmelev@mail.ru

SHMELEVA NATALIA M., C. Med. Sci., senior researcher of the Department of tuberculosis differential diagnosis and extracorporeal methods of treatment of Central Tuberculosis Research Institute, Russia, 107564, Moscow, Yauzskaya alley, 2, tel. +7-499-785-90-31, e-mail: eishmelev@mail.ru

Abstract. Aim. The aim of the study was to study clinical, radiological, and functional indicators in patients with hyper-sensitivity pneumonia in combination with coronary heart disease and to assess the impact of these diseases on eachother. Material and methods. The study enrolled 48 patients with hypersensitivity pneumonia and 23 patients withcoronary heart disease. The patients were divided into two groups. The primary group consisted of 22 patients withhypersensitivity pneumonia combined with coronary heart disease. The comparison group included patients from two subgroups: 26 patients with hypersensitivity pneumonia without coronary heart disease, and 23 patients with coronaryheart disease without hypersensitivity pneumonia. The presence of coronary heart disease was con rmed by typical clinical manifestations, electrocardiographic and echocardiography changes. 6-minute walk test, spirometry, bodyplethysmography, study of lung diffusion ability were performed to assess functional status. Clinical symptoms, radiation and echocardiography studies data were analyzed. Results and discussion. The intensity of clinical symptoms(shortness of breath, cough) was signi cantly higher in the primary group than in the comparison groups. The tolerance of physical activity, estimated from the six-minute step test, was signi cantly lower in the primary group. The nature of clinical status correlated with functional study data. Volumetric and velocity indices in spirometry tended to decrease more in the primary group than in both comparison groups. The lung diffusivity indices were signi cantly lower in the group of patients with hyper-sensitivity pneumonia combined with coronary heart disease in comparison with the group of patients with coronary heart disease only. There were no signi cant differences with the group with hyper-sensitivity pneumonia. A similar trend was observed in the chest CT evaluation: signi cantly more pronounced changes were revealed in the primary group. The evaluation of the echocardiography data revealed a signi cant increase in pulmonaryhypertension of the right heart sections in the primary group compared to the group of patients with coronary heartdisease. Conclusion. We have obtained data evidencing higher intensity of respiratory symptoms, more pronounced inflammatory changes, decreased functional status, ventilation disorders, and dilatation of heart cavities, higher risk of fatal vascular complications in patients with hyper-sensitivity pneumonia associated with coronary heart disease.

Key words: hyper-sensitivity pneumonia, cardiovascular diseases, coronary heart disease.

For reference: Medvedev AV, Abubikirov AF, Zaitseva AS, Mazaev LA, Makaryants NN, Shmelev EI, Shmeleva NM. Hyper-sensitivity pneumonia combined with coronary heart disease: clinical, radiological, and functional features. The Bulletin of Contemporary Clinical Medicine. 2020; 13 (3): 19-27. DOI: 10.20969/VSKM.2020.13(3).19-27.

References

  1. Oganov RG, Denisov IN, Samanenkov VI. Komorbidnaya patologiya v klinicheskoj praktike [Comorbid pathology in clinical practice]. Kardiovaskulyarnaya terapiya i pro laktika [Cardiovascular therapy and prevention]. 2017; 16 (6): 5-56.

  2. Il’kovich MM, Orlova GP. Ekzogennyj allergicheskij al’veolit v knige: Intersticial’nye i orfannye zabolevaniya legkih, pod redakcij MM Il’kovicha [Exogenous Allergic Alveolitis in the Book: Interstitial and Orphan Pulmonary Diseases, edited by MM Ilkovich]. Moskva: GEOTAR – Media [Moscow: GEOTAR – Media]. 2016; 3 (2): 114 – 140.

  3. Lacasse Y, Girard M, Cormier Y. Recent advances in hypersensitivity pneumonitis. Chest. 2012; 142 (1): 208-217.

  4. Sforza GGR, Marinou A. Hypersensitivity pneumonitis: a complex lung disease. Clin Mol Allergy. 2017; 15: 6.

  5. Hsieh C, Kamangar H. Hypersensitivity Pneumonitis. Chief Editor: Byrd RP Updated. 2015; 286 p.

  6. Orlova GP, Il’kovich MM, Nikolaeva YuV. Amidaron – inducirovannyj ekzogennyj toksicheskij al’veolit [Amidaron – induced exogenous toxic alveolitis]. Doktor –ru. 2015; 3-4: 44-49.

  7. Churg A, Muller NL, Flint J, Wright JL. Chronic hypersensitivity pneumonitis. Am J Surg Pathol. 2006; 30 (2): 201-208.

  8. Churg A, Bilawich A, Wright JL. Pathology of chronic hypersensitivity pneumonitis what is it? What are the diagnostic criteria? Why do we care? Arch Pathol Lab Med. 2018; 142: 109–119.

  9. Selman M, Pardo A, King TE. Hypersensitivity Pneumonitis Insights in Diagnosis and Pathobiology. Am J Respir Crit Care Med. 2012; 186 (Iss. 4): 314-324.

  10. Baldwin CL, Todd A, Bourke S, et al. Pigeon fanciers lung: effects of smoking on serum and salivary antidody responses to pigeon antigens. Clin Exp Immunol. 1998; 113: 166-172.

  11. Bourke SJ, Carrer R, Andersen K, et al. Obstructive airways disease in non-smoking subjects with pigeon fanciers lung. Clin Exp Allergy. 1989; 19: 629-632.

12. Stabil’naya ishemicheskaya bolezn’ serdca: klinicheskie rekomendacii [Stable coronary heart disease / Clinical recommendations]. Moskva: Medicina [Moscow: Medicine]. 2016; 28-56. http://webmed.irkutsk.ru/doc/pdf/ fedcad.pdf

13. Lesnyak VN, Anan’eva LP, Koneva OA, Goryachev DV, Zvezdkina EA, Kochanova MN, Desinova OV, Ovsyannikova OB. Polukolichestvennye vizual’nye metody ocenki vyrazhennosti intersticial’nyh porazhenij legkih po dannym komp’yuternoj tomogra i [Semi-quantitativevisual methods for assessing the severity of interstitiallung lesions according to computed tomography]. Pul’monologiya [Pulmonology]. 2017; 27 (1): 41–50.

14. Mascolo MC, Truwit JD. Role of exercise evaluation in restrictive lung disease: new insinghts between Mars 2001 and February 2003. Curr Opin Pulm Med. 2003; 9 (5): 408-410.

15. Avdeeva OE, Aisanov ZR, Kalmanova EN, et al. Exercise limitation in patients with interstitial lung disease. Eur Respir J. 1997; 10 (25), 0491: 65.

16. Vasyuk YuA, Kopeleva MV, Korneeva OYu, Krikunov PV, Ryabov VV, Surkova EA, Shkol’nik EL. Rekomendacii po kolichestvennoj ocenke struktury i funkcii kamer serdca [Recommendations for the quantitative assessment of the structure and function of the heart chambers]. Rossijskij kardiologicheskij zhurnal [Russian Journal of Cardiology]. 2012; 3 (95): 1-28.

17. Oliveira RKF, Pereira CAC, Ramos RP, Ferreira EVM, Messina CMS, Kuranishi LT, Gimenez A, Campos O, Silva CMC, Ota-Arakaki JS. A Haemodynamic Study of Pulmonary Hypertension in Chronic Hypersensitivity Pneumonitis. Eur Respir J. 2014; 44 (2): 415-424.

18. Shal’nev VI. Rol’ vospalitel’nyh faktorov v patogeneze ateroskleroticheskogo porazheniya sosudov [The role of in ammatory factors in the pathogenesis of atherosclerotic vascular lesions]. Rossijskij semejnyj vrach [Russian family doctor]. 2005; 9 (3): 4-11.

19. Paul A, Ko K, Lее L, et al. C-reactive protein accelerates the progression of atherosclerosis in аpрo-lipoprotein E-de cient mice. Circulation. 2004; 109 (5): 647-655.

20. Gavrilova NE, Petrova NV, YArovaya EB, Mazaev VP, Urazalina SZh, Bojcov SA. Vzaimosvyaz’ mezhdu vyrazhennost’yu koronarnogo ateroskleroza, faktorami riska i markerami ateroskleroticheskogo porazheniya karotidnyh i perifericheskih arterij [The relationship between the severity of coronary atherosclerosis, risk factors, and markers of atherosclerotic lesions of the carotid and peripheral arteries]. Kardiovaskulyarnaya terapiya i profilaktika [Cardiovascular therapy and prevention]. 2013; 12 (1): 40-45.

21. Morisset J, Johannson KA, Jones KD, Wolters PJ, Collard HR, Walsh SLF, et al. Identi cation of diagnostic criteria for chronic hypersensitivity pneumonitis: an International Modi ed Delphi Survey. Am J Respir Crit Care Med. 2018; 197: 1036–1044.

22. Ershova AI, Deev AD, Aleksandrova EL, Bojcov SA, et al. Ateroskleroticheskaya blyashka v sonnyh arteriyah kak marker riska serdechno – sosudistyh sobytij v populyacii srednego vozrasta [Atherosclerotic plaque in the carotid arteries as a marker of the risk of cardiovascular events in the middle-aged population]. Kardiovaskulyarnaya terapiya i pro laktika [Cardiovascular therapy and prevention]. 2018; 17 (4): 34-39.

 

UDC 616.131-005.755-089

DOI: 10.20969/VSKM.2020.13(3).28-35

PDF download INTEGRATED ANALYSIS OF SURGICAL METHODS OF PULMONARY EMBOLISM PREVENTION

FEDOROV SERGEY A., ORCID ID: 0000-0002-5930-3941; C. Med. Sci., cardiovascular surgeon of Specialized Heart Surgery Clinical Hospital named after аcademician B.A. Korolev, Russia, 603950, Nizhny Novgorod, Vaneev str., 209, e-mail: Sergfedorov1991@yandex.ru

MEDVEDEV ALEXANDER P., ORCID ID: 0000-0003-1757-5962; D. Med. Sci., professor of the Department of advanced surgery named after B.A. Korolev of Volga Research Medical University, Russia, 603005, Nizhny Novgorod, Minin i Pozharsky sq., 10/1, e-mail: medvedev.map@yandex.ru

MAXIMOV ANTON L., ORCID ID: 0000-0002-7241-7070; C. Med. Sci., chief physician of Specialized Heart Surgery Clinical Hospital named after academician B.A. Korolev, Russia, 603950, Nizhny Novgorod, Vaneev str., 209, e-mail: maximoval@mail.ru

ABDULYANOV ILDAR V., ORCID ID: 0000-0003-2892-2827; C. Med. Sci., cardiovascular surgeon, Head of the Department of cardiology, roentgen-endovascular and cardiovascular surgery of Kazan State Medical Academy – the branch of Russian Medical Academy of Postgraduate Education, Russia, 420012, Kazan, Butlerov str., 36, е-mail: ildaruna@mail.ru

ZHURKO SERGEY A., ORCID ID: 0000-0002-5222-1329, C. Med. Sci., cardiovascular surgeon of Specialized Heart Surgery Clinical Hospital named after Academician B.A. Korolev, Russia, 603950, Nizhny Novgorod, Vaneev str., 209, e-mail: zhurkoser@mail.ru

TSELOUSOVA LADA M., ORCID ID: 0000-0002-6005-2684; postgraduate student of the Department of advanced surgery named after B.A. Korolev of Volga Research Medical University, Russia, 603005, Nizhny Novgorod, Minin i Pozharsky sq., 10/1, e-mail: ladamc@rambler.ru

TROFIMOV NIKOLAY A., ORCID ID: 0000-0002-1975-5521; C. Med. Sci., cardiovascular surgeon of Republican Cardiology Dispensary, Russia, 428020, Cheboksary, Fedor Gladkov str., 29a, e-mail: nikolai.trofimov@mail.ru

MIRONOV EVGENIY A., ORCID ID: 0000-0002-6005-2145; cardiovascular surgeon of Specialized Heart Surgery Clinical Hospital named after academician B.A. Korolev, Russia, 603950, Nizhny Novgorod, Vaneev str., 209, e-mail: b.spinoza@mail.ru

Abstract. Aim. The aim of the study was to evaluate the outcomes of surgical and endovascular methods of pulmonaryartery embolism prevention and to design an algorithm of surgical pulmonary artery embolism prevention. Material and methods. 164 patients with acute thrombosis of the vena cava inferior system, dangerous in terms of embolism were enrolled in the ongoing study. Women prevailed in the overall group of patients, which accounted for 55,69% (93 patients). The age of patients ranged from 18 to 82 years old and on the mean it was (54,21±6,08) years. Depending on the chosen treatment strategy, 2 groups of patients were identi ed. The rst group consisted of 48 (27,9%) people, who underwent lower limb vein plication. At the same time, the lower limb vein plication was supplemented with thrombectomy from the distal sections of the venous bed in 100% of cases. The second group of patients consisted of 124 people, who were implanted with cava lters. Results and discussion. The 30-day mortality rate in the overall group of patients was 0,6% (1 patient in group I). The cause of the lethality was a massive embolism of the pulmonary artery. Reopening of the venous bed of the affected limb segment was achieved in the patients of the I group by the moment of discharge, the phenomena of lymphatic insuf ciency were eliminated. In the long-term follow-up period we did not reveal any lethal outcomes in patients of the I group. 7 lethal outcomes were recorded in patient group II during the observation period of up to 6 years. We revealed massive embolism in the previously implanted cava lter in 10 patients of the II group within the period of up to 36 months, which required intensive conservative therapy in 6 cases, as well as thrombolytic therapy in 4 patients. Conclusion. We consider the size of the otation head over 3,5 cm to be dangerous in terms of embolism. We consider the localization of the oating head below the inguinal ligament level to be an indication of plication and thrombectomy from distal parts of the venous bed. In case of thrombosis spreading above the inguinal ligament level, we consider retrograde iliocavography to be obligatory due to low ef ciency of routine duplex scanning techniques of the given anatomical region. We consider the following to be the indications for the cavalter implantation: the presence of a otation head localized above the level of the inguinal ligament and below the renal vein entry; the incapability to perform adequate anticoagulant therapy; and a recurrent form of the pulmonary embolism.

Key words: cava lter, venous plication, oating thrombosis.

For reference: Fedorov SA, Medvedev AP, Maximov AL, Abdulyanov IV, Zhurko SA, Tselousova LM, Tro mov NA, Mironov EA. Integrated analysis of surgical methods of pulmonary embolism prevention. The Bulletin of Contemporary Clinical Medicine. 2020; 13 (3): 28-35. DOI: 10.20969/VSKM.2020.13(3).28-35.

References

  1. Lin YC, Chen SC, Huang CM, Hu YF, Chen YY, Chang SL, Lo LW, Lin YJ, Chen SA. Clinical features and diagnosisof new malignancy in patients with acute pulmonaryembolism and without a history of cancer. Journal of the Chinese Medical Association. 2020; 83, (3): 245-250.

  2. Patel JJ, Bergl PA. Illuminating Gestalt in Diagnosing Acute Pulmonary Embolism. Am J Med. 2020; 133 (2): e62-e63. https://doi.org/10.1016/j.amjmed.2019.08.016.

  3. Noboa S, Mottier D, Oger E. Estimation of a potentially preventable fraction of venous thromboembolism: a community-based prospective study. EPI-GETBO Study Group. Journal of Thrombosis and Haemostasis. 2007; 4 (12): 2720-2722. https://doi.org/10.1111/j.1538-7836.2006.02196.x

  4. Gregson J, Kaptoge S, Bolton T, Pennells L, Willeit P, Burgess S, Bell S, Sweeting M, Rimm EB, Kabrhel C, Zöller B, Assmann G, et al. Cardiovascular Risk Factors Associated With Venous Thromboembolism. JAMA Cardiol. 2019; 4 (2): 163-173.

  5. Jaff MR, McMurtry MS, Archer SL, et al. Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scienti c statement from the American Heart Association. Circulation. 2012; 7: 1788-1830.

  6. Vorob’eva NM, Panchenko EP, Ermolina OV, Balakhonova TV, Dobrovol’skiĭ AB, Titaeva EV, Khasanova ZB, Postnov AI, Kirienko AI. Prolongation of enoxaparin therapyto one month promotes recanalization of the occlusivelythrombosed deep veins. Terapevticheskii arkhiv. 2011; 83 (8): 33-37.

  7. Mironov AV, Leont’ev SG, Ustinov FS, Efremova OI, Lebedev IS, Kirienko AI. How to validate the symptoms of pulmonary thromboembolism: how diagnostic scales help. Terapevticheskii arkhiv. 2013; 85 (4): 11-15.

  8. Claeys MJ, Vandekerckhove Y, Cosyns B, Van de Borne P, Lancellotti P. Summary of 2019 ESC Guidelines on chronic coronary syndromes, acute pulmonary embolism, supraventricular tachycardia and dislipidaemias. Acta Cardiologica. 2020; 10: 1-8. https://doi.org/10.1080/0001 5385.2019.1699282.

  9. Zatevakhin II, Tsitsiashvili MSh, Mishnev AD, Trusov OA, Matyushkin AV. Posleoperacionnye venoznye tromboembolicheskie oslozhneniya, naskol’ko real’na ugroza? [Postoperative venous thromboembolic complications, how real is the threat?]. Angiologiya I sosudistaya hirurgiya [Angiology and vascular surgery]. 2002; 8 (1): 17–21.

  10. Medvedev AP, Fedorov SA. Uspeshnoe hirurgicheskoe lechenie massivnoj tromboembolii legochnoj arterii s odnomomentnym protezirovaniem mitral’nogo klapana [Successful surgical treatment of massive pulmonary embolism with simultaneous mitral valve replacement]. Grudnaya i serdechno-sosudistaya hirurgiya [Thoracic and cardiovascular surgery]. 2018; 60 (3): 254-260. https://doi.org/ 10.24022 / 0236-2791-2018-60-3-254-260. 

  11. Margulis MS, Savchenko VB, Eĭdel’man LA, Golovaneva NB, Sokolov AV. Tromboemboli in the pulmonary artery system in the early postoperative period. Khirurgiia. 1988; 10: 112-115.

 

UDC [616.24-002.5:616.24-036.12]-085.234

DOI: 10.20969/VSKM.2020.13(3).35-40

PDF download EXPERIENCE OF (OLODATEROL/TIOTROPIUM BROMIDE – RESPIMAT) COMBINATION BRONCHODILATOR APPLICATION IN PATIENTS WITH RESPIRATORY TUBERCULOSIS COMBINED WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

KHANIN ARKADIY L., D. Med. Sci., professor, Honored doctor of the Russian Federation, the Head of the Department of phthisiopulmonology of Novokuznetsk State Institute for Physicians’ Professional Development – the branch Campus of the Russian Medical Academy of Continuous Professional Education, Russia, 654005, Novokuznetsk, Stroitel ave., 5, tel/fax: 8 (3843) 45-42-19, e-mail: prof.khanin@yandex.ru

KRAVETS SVETLANA L., phthisiologist of Prokop’evsk Tuberculosis Dispensary, Russia, 653024, Prokop’evsk, Serov str., 6, tel. +7-904-963-21-02, e-mail: kompasha3@mail.ru

Abstract. Aim. The aim of the study was to evaluate the ef cacy of complex therapy for patients with a combination of respiratory tuberculosis and chronic obstructive pulmonary disease with the use of olodaterol/tiotropium bromide-respimat inhalation and antibacterial therapy. Material and methods. Comparative study enrolled patients with respiratorytuberculosis and chronic obstructive pulmonary disease (42 patients). The rst group – 22 patients with combineddisease, additionally were receiving olodaterol/tiotropium bromide in the form of respimat inhalations of 5 μg/day, in the morning, for 30 days during the intensive stage of pulmonary tuberculosis therapy in addition to antibacterial therapyof tuberculosis. Comparison group – 20 patients with similar types of pulmonary tuberculosis and chronic obstructive pulmonary disease were treated by only tuberculosis therapy according to the drug sensitivity test and any by means ofshort-range acting bronchodilators «on demand». The methods of examination and evaluation of treatment ef cacy in patients with chronic obstructive pulmonary disease and lung tuberculosis, generally accepted in modern pulmonology and phthisiology, were applied. Results and discussion. In the rst group of patients who were receiving additional olodaterol/tiotropium bromide inhalation after one month of therapy, there was an improvement in clinical and functional data: average CAT and MRC scores decreased from 16,6 to 8,7 and from 1,68 to 1,05, respectively. The FEV1 increased from 57,04 to 65,3% and the forced volume vital capacity from 63,8 to 70,6%. In the group of comparison there was no improvement on pulmonary function test. In the rst group negative reaction of sputum smear detected by simple microscopy after one month of complex therapy has occurred in 90,9%. Positive radiological trends such as reduction of in ltration and size of pulmonary tissue destruction have been observed in 86,3%, while in the comparison group it was only 61,0 and 46,0% (respectively). Conclusion. In the rst group there was distinctly faster cessation of bacterial discharge con rmed by sowing and closure of necrotic cavities in case of pulmonary tuberculosis, which allowed to transfer patients from round-the-clock stay in hospital to daily care hospital earlier.

Key words: chronic obstructive pulmonary disease, tuberculosis, comorbidities, olodaterol/tiotropium bromide, treatment ef cacy.

For reference: Khanin AL, Kravets SL. Experience of (olodaterol / tiotropium bromide – respimat) combination bronchodilator application in patients with respiratory tuberculosis combined with chronic obstructive pulmonary disease. The Bulletin of Contemporary Clinical Medicine. 2020; 13 (3): 35-40. DOI: 10.20969/VSKM.2020.13(3).35-40.

References

  1. Avdeev SN. Pro laktika obostrenij hronicheskoj obstruktivnoj bolezni legkih [Prevention of exacerbations of chronic obstructive pulmonary disease]. Pul’monologiya [Pulmonology]. 2016; 5: 101–108.

  2. Bilichenko TN, Bystrickaya EV, CHuchalin AG, et al. Smertnost’ ot boleznej organov dyhaniya v 2014-2015gg. i puti ee snizheniya [Mortality from respiratory diseases in 2014-2015 and ways to reduce it]. Pul’monologiya [Pulmonology]. 2016; 4: 23−28.

  3. Va n AYu, Vizel’ AA, SHerputovskij VG, et al. Zabolevaniya organov dyhaniya v Respublike Tatarstan: mnogoletnij epidemiologicheskij analiz [Respiratory diseases in the Republic of Tatarstan: long-term epidemiological analysis]. Vestnik sovremennoj klinicheskoj mediciny [Bulletin of modern clinical medicine]. 2016; 1: 24–31.

  4. Makarov IA, Potapova IA, Makeeva NV. Osobennosti dinamiki professional’noj hronicheskoj obstruktivnoj bolezni legkih u rabochih pylevyh professij [Features of thedynamics of occupational chronic obstructive pulmonarydisease in workers of dust professions]. Pul’monologiya [Pulmonology]. 2017; 1: 37−40.

  5. Global Initiative for Chronic Obstructive Lung Diseases (COLD-2017). Global strategy for diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WNO workshop report. 2017; www.goldcopd.com

  6. Hanin AL, Chernushenko TI, Kravchenko NI. Rasprostranennost’ respiratornyh simptomov i vozmozhnosti vyyavleniya hronicheskoj obstruktivnoj bolezni legkih v shahterskom gorode Kuzbassa [The prevalence ofrespiratory symptoms and the possibility of detecting chronic obstructive pulmonary disease in the miningtown of Kuzbass]. Pul’monologiya [Pulmonology]. 2012; 3: 59−62.

  7. Hanin AL, Chernushenko TI. Problemy boleznej organovdyhaniya i vozmozhnye puti ih resheniya na urovnemunicipal’nogo zdravoohraneniya [Problems of respiratorydiseases and possible ways to solve them at the level ofmunicipal health care]. Pul’monologiya [Pulmonology]. 2011; 2: 115−118.

  8. Krasnov VA, Revyakina OV, Alekseeva TV, et al. Osnovnye pokazateli protivotuberkuleznoj deyatel’nosti v Sibirskom i Dal’nevostochnom federal’nyh okrugah [Main indicators of anti-TB activity in the Siberian and far Eastern Federal districts]. Novosibirsk: NGMU [Novosibirsk: IPC NGMU]. 2017; 92 р.

  9. Hanin AL, Hanina NM. Problema tuberkuleza i HOBL [The problem of tuberculosis and COPD]. Kemerovo: Sbornik Vserossijskoj konferencii: Effektivnye tekhnologii organizacii medicinskoj pomoshchi [Kemerovo: Effective technologies for organizing medical care: a collection of the All-Russian Conference]. 2004; 198−200.

  10. Hanin AL, Chumakova LP. Hronicheskaya obstruktivnaya bolezn’ legkih (klinika, diagnostika, lechenie) [Chronic obstructive pulmonary disease (clinic, diagnosis, treatment)]. Novokuznetsk: NGMU [Novokuznetsk: NGMU]. 2007; 79 р.

  11. Mordyk АV, Barysheva NV, Ivanova OG, Batishchev TL, Bekmukhambetova NIn. Kliniko-epidemiologicheskie osobennosti tuberkuleza verhnih i nizhnih dyhatel’nyh putej u bol’nyh s hronicheskim nespeci cheskimi zabolevaniyami legkih [Clinical and epidemiological features of upper andlower respiratory tract tuberculosis in patients with chronicnon-speci c lung diseases]. Folia Otorhinolaryngologiae et Pathologiae Respiratoriae. 2016; 22 (1): 84-90.

  12. Hanin AL, Kravec SL. Hronicheskaya obstruktivnaya bolezn’ legkih i tuberkulez: aktual’naya problema v real’noj praktike (obzor literatury) [Chronic obstructive pulmonary disease and tuberculosis: an actual problem in real practice (literature review)]. Vestnik sovremennoj klinicheskoj mediciny [Bulletin of modern clinical medicine]. 2017; 10: 60-70.

  13. Vasilyeva IA, Ergeshov AE, Maryandyshev AO, et al. Federal’nye klinicheskie rekomendacii po diagnostike i lecheniyu tuberkuleza organov dyhaniya [Federalclinical guidelines for the diagnosis and treatment ofrespiratory tuberculosis]. Moskva: ROF [Moscow: ROF]. 2014; 38 р.

 

REVIEWS

UDC 616.127-005.4-039.56-07:[616.127-073.916.3+616.132.2-073.75](048.8)

DOI: 10.20969/VSKM.2020.13(3).41-46

PDF download MYOCARDIAL SCINTIGRAPHY AND CORONARY ANGIOGRAPHY CAPABILITIES IN THE DIAGNOSIS OF CORONARY ARTERY LESIONS IN PAINLESS MYOCARDIAL ISCHEMIA

ABDRAKHMANOVA ALSU I., ORCID ID: 0000-0003-0769-3682; SCOPUS Author ID: 57192296744; C. Med. Sci., associate professor of the Department of clinical medicine fundamental basis of Institute of biology and fundamental medicine of Kazan Federal University, Russia, 420012, Kazan, Karl Marx str., 74; doctor of the Department of cardiology of Interregional Clinical Diagnostic Center, Russia, 420089, Kazan, Karbyshev str., 12а, e-mail: alsuchaa@mail.ru

TSIBULKIN NIKOLAY A., ORCID ID: 0000-0002-1343-0478; C. Med. Sci., associate professor of the Department of cardiology, roentgen-endovascular and cardiovascular surgery of Kazan State Medical Academy – the branch of Russian Medical Academy of Continuons Professional Education, Russia, 420012, Kazan, Butlerov str., 36

AMIROV NAIL B., ORCID ID: 0000-0003-0009-9103; SCOPUS Author ID: 7005357664; D. Med. Sci., professor of the Department of general medical practice of Kazan State Medical University, 420012, Russia, Kazan, Butlerov str., 49, e-mail: namirov@mail.ru

Abstract. Aim. The aim of the study was to analyze medical literature on the connection between different degrees of coronary artery lesions detected during coronary angiography and the results of single photon emission computed tomography. Material and methods. The analysis of research results of recent years devoted to the comparison of coronaroangiography and single photon emission computed tomography data was conducted. Results and discussion. The persistent perfusion defects are found in up to 50% of patients with coronary artery stenosis in 45–68% of cases. In 20% of cases perfusion defects at rest were found. In 0,07–15% perfusion defects at physical activity were found. In patients with coronary artery stenosis over 50% in 14% there were persistent perfusion defects, in 0,04% – reversible defect at rest, and in 27–30% – perfusion defects at physical activity. Single photon emission computed tomography revealed the defeat of one vessel in 21–93% of cases, multivascular defeat in 79–91%, and speci city in 28%. The majority of perfusion disorders occur in the pool of anterior interventricular branch and less often in the pool of the circum ex branch. In case of negative results of single photon emission computed tomography stenosis was revealed in 23,3% to 36,6% of the cases. Coronary artery lesions of high risk were revealed in 7,2% of patients. Sensitivity of single photon emission computed tomography in detection of hemodynamically signi cant stenoses of coronary arteries was 40–67,9%, and speci city was 70,9–87%. At coronary artery stenoses more than 50% sensitivity was 96,4–97%, and speci city was 82–84,2%. Conclusion. The inconsistency of the available data on the severity of coronary artery lesions in patients with painless myocardial ischemia revealed by a single photon emission computed tomography, as well as on the sensitivity and speci city of this method, requires further investigation and conduction of original study.

Key words: perfusion scintigraphy, сoronary angiography, diagnostics, painless myocardial ischemia.

For reference: Abdrakhmanova AI, Tsibulkin NA, Amirov NB. Myocardial scintigraphy and coronary angiography in the diagnosis of coronary artery lesions in painless myocardial ischemia. The Bulletin of Contemporary Clinical Medicine. 2020; 13 (3): 41-46. DOI: 10.20969/VSKM.2020.13(3).41-46.

References

  1. Amirov NB, Abdrahmanova AI, Sajfullina GB, et al. Bezbolevaya ishemiya [Painless ischemia]. Kazan’: Medicina [Kazan:Medicine]. 2018; 83 р.

  2. Goluhova EZ, Gromova OI, Bulaeva NI, et al. Vnezapnaya serdechnaya smert’ u bol’nyh ishemicheskoj bolezn’yu serdca: ot mekhanizmov k klinicheskoj praktike [Sudden cardiac death in patients with coronary heart disease: from mechanisms to clinical practice]. Kardiologiya [Cardiology]. 2017; 12: 73–81.

3. Mit’kovskaya NP, Pateyuk IV, Statkevich TV, et al. Bezbolevaya ishemiya miokarda u pacientov s metabolicheskim sindromom: strati kaciya kardiovaskulyarnogo riska [Painless myocardial ischemia in patients with metabolic syndrome: strati cation of cardiovascular risk]. Novosti mediko-biologicheskih nauk [Life Sciences News]. 2015; 3: 39—42.

4. Abdrahmanova AI, Amirov NB, Abdulyanov IV, Gaifullina RF, Oslopova JV. The question of coronary artery damage in silent myocardial ischemia. The Bulletin of Contemporary Clinical Medicine. 2018; 11 (6): 57-62. DOI: 10.20969/VSKM.2018.11(6).57-62

5. Majanskaja SD. Osobennosti porazhenija koronarnogo rusla u pacientov s bezbolevoj ishemiej miokarda [Featuresof coronary lesion in patients with painless ischemia of themyocardium].Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Contemporary Clinical Medicine]. 2013; 4: 74‒79.

6. Abdrahmanova AI, Oslopova JV, Abduljanov IV. Coronary Artery Disease in Patients whith Silent Mjocardial Ischemia According To the Coronary Angiographic Data. International Journal of Advanced Biotechnology and Research. 2016; 4: 1564-1568 .

7. Abdrahmanova AI, Amirov NB, Sajfullina GB. Bezbolevaja ishemija miokarda (obzor literatury) [Painless myocardial ischemia (literature review)]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Contemporary Clinical Medicine]. 2015; 6: 103-115.

8. Shlyahto EV. Kardiologiya: nacional’noe rukovodstvo [Cardiology: national leadership]. Moskva: GEOTAR – Media [Moscow: GEOTAR -Media]. 2015; 800 р.

9. Abdrakhmanova AI, Saifullina GB, Amirov NB, Khusainova AK, Khasanova AG. Pokazateli perfuzionnoy tomostsintigra i miokarda pri bezbolevoy ishemiii miokarda [Myocardial perfusion tomoscintigraphy indicators in silent myocardial ischemia]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Contemporary Clinical Medicine]. 2020; 13 (1): 54-61. DOI: 10.20969/ VSKM.2020.13(1).54-61.

10. Patyuik IV, Mitkovskaya NP, Terekhov VI, et al. Odnofotonnaya emissionnaya komp’yuternaya tomogra ya i skrining koronarnogo kal’ciya v diagnostike ishemii miokarda i strati kacii riska u pacientov s bessimptomnoj depressiej segmenta ST [Single-photon emissioncomputed tomography and coronary calcium screening forthe diagnosis of myocardial ischemia and risk strati cation in patients with asymptomatic ST segment depression]. Lechebnoe delo [Medical business]. 2015; 5: 33-37.

11. Sergienko VB, Ansheles AA, Shul’gin DN. Perfuzionnaya scintigrafiya i OEKT miokarda (metodicheskie rekomendacii) [Myocardial perfusion scintigraphy and SPECT (guidelines)]. Kardiologicheskij vestnik: Byulleten’ Rossijskogo kardiologicheskogo nauchno-proizvodstvennogo kompleksa [Cardiological Bulletin: Bulletin of the Russian Cardiology Research and Production Complex]. 2015; 2: 6—21.

12. Ryzhkova DV. Perfuzionnaya scintigrafiya [Perfusion scintigraphy]. Kardiologiya; Novosti; Mnenie; Obuchenie [Cardiology; News; Opinion; Training]. 2016; 4: 76-86.

13. Ansheles AA, Mironov SP, Shul’gin DN, et al. Perfuzionnaya OEKT miokarda s KT – korrekciej pogloshcheniya: principy polucheniya i interpretacii dannyh (metodicheskie rekomendacii) [Perfusion myocardial SPECT with CT – correction of absorption: principles of obtaining and interpreting data (guidelines)]. Luchevaya diagnostika i terapiya [Radiation diagnostics and therapy]. 2016; 3 (7): 87-101.

  1. Trufanov GE, Dekan VS, Romanov GG, et al. Perfuzionnaya scintigrafiya miokarda [Myocardial perfusion scintigraphy]. SPb: Elbi. 2012; 80 р.

  2. Abdrahmanova AI, Oslopova JV, Esin OR, et al. Main metod of diagnosis of silent myocardial ischemia. International Journal of Pharmacy and Technology IJPT. 2016; 4 (8): 24400-24406.

  3. Ansheles AA, Shul’gin DN, Solomyanyj VV, et al. Sopostavlenie rezul’tatov nagruzochnyh prob, dannyh odnofotonnoj emissionnoj komp’yuternoj tomografii i koronarografii u bol’nyh ishemicheskoj bolezn’yu serdca [Comparison of the results of stress tests, data of single-photon emission computed tomography and coronarography in patients with coronary heart disease]. Kardiologicheskij vestnik [Cardiological Bulletin]. 2012; 2: 10-16.

  4. Ansheles AA, Sergienko IV, Sergienko VB. Sovremennoe sostoyanie i perspektivnye tekhnologii radionuklidnoj diagnostiki v kardiologii [Current state and promising technologies of radionuclide diagnostics in cardiology]. Kardiologiya [Cardiology]. 2018; 6: 61–69.

  5. Montalescot G, Sechtem U, Achenbach S, Andreotti F, Arden C, Budaj A, et al. 2013 ESC guidelines on the management of stable coronary artery disease: The Task Force on the management of stable coronary artery disease of the European Society of Cardiology. Eur Heart J. 2013; 34: 2949–3003.

  6. Mihajlov EV, Shamurova YuYu, Tancyreva IV, et al. Perfuzionnaya scintigrafiya miokarda i chreskozhnoe koronarnoe vmeshatel’stvo u pacientov so stenoziruyushchim porazheniem koronarnyh arterij [Perfusionscintigraphy of the myocardium and percutaneous coronary intervention in patients with stenotic lesions ofthe coronary arteries]. Ural’skij medicinskij zhurnal [Ural medical journal]. 2018; 10: 60–65.

  7. Mihajlov EV, Men’shikova ES, Grebenyuk EA, et al. Rezul’taty perfuzionnoj scintigra i miokarda i koronarnoj angiogra i u rabotnikov zheleznodorozhnogo transporta s aritmiyami serdca [Results of myocardial perfusionscintigraphy and coronary angiography in railwaytransport workers with cardiac arrhythmias]. Chelyabinsk: Materialy Vserossijskoj nauchno-prakticheskoj konferencii, posvyashchennoj 90-letiyu zasluzhennogo deyatelya nauki RF, professora DA Glubokova “Aktual’nye problemy polipatij v klinicheskoj i profilakticheskoj medicine” [Chelyabinsk: Actual problems of polypathies in clinical and preventive medicine]. 2013; 167–170.

21. Denisenko-Kankiya EI, Chanahchyan FN, Vasilenko EI. Sravnitel’nyj analiz dannyh perfuzionnoj scintigra i miokarda u pacientov s porazheniem koronarnyh arterij [Comparative analysis of myocardial perfusion scintigraphy data in patients with coronary artery disease]. Kardiologicheskij vestnik [Cardiology journal]. 2019; 4: 58-65.

  1. Litvinenko IV. Vozmozhnosti OFEKT-KT v diagnostike stenozov koronarnyh arterij [Possibilities of SPECT-CT in the diagnosis of coronary artery stenosis]. Medicinskaya vizualizaciya [Medical imaging]. 2015; 2: 53-66.

  2. Patel MR, Dai D, Hernandez AF, et al. Prevalence andpredictors of nonobstructive coronary artery diseaseidenti ed with coronary angiography in contemporary clinical practice. American Heart Journal. 2014; 167: 846–852.

24. Sumin AN. Ocenka predtestovoj veroyatnosti v diagnostike obstruktivnyh porazhenij koronarnyh arterij: nereshennye voprosy [Assessment of pre-test probability in the diagnosis of obstructive coronary artery lesions: unresolved issues]. Rossijskij kardiologicheskij zhurnal [Russian journal of cardiology]. 2017; 6 (11): 68–76.

25. Zavodovskij KV, Gulya MO, Lishmanov YUB. Sostoyanie miokardial’noj perfuzii u pacientov s pogranichnymi i gemodinamicheski znachimymi stenozami koronarnyh arterij; Nauchnoe izdanie [State of myocardial perfusion in patients with borderline and hemodynamically signi cant coronary artery stenosis; Scienti c publication]. Kongress Rossijskoj Associacii radiologov [Congress of the Russian Association of radiologists]. 2014; 482.

26. Solomyanyy VV, Sergienko IV, Samko AN. Quantitativeassessment of the hemodynamic relevance of borderlinecoronary stenosis by myocardial single-photon emissioncomputed tomography with radiation absorption correctionversus fractional ow reserve. Journal of radiology and nuclear medicine. 2014; 6: 39-46.

27. Kuznetsov VA, Yaroslavskaya EI, Gorbatenko EA. Predictors of hemodynamically significant coronarystenosis in patients with disturbed myocardial perfusionbased on the results of single-photon emission computed tomography. Clinical Medicine. 2012; 7: 25-30.

28. Levine GN, Bates ER, Blankenship JC, et al. 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention. J Am Coll Cardiol. 2011; 58: 44–122.

29. Romanov GG. Sravnitel’naya ocenka diagnosticheskih vozmozhnostej perfuzionnoj EKG-sinhronizirovannoj odnofotonnoj emissionnoj komp’yuternoj tomografii miokarda i koronarogra i v vyyavlenii stenozov koronarnyh arterij [Comparative evaluation of diagnostic capabilities of perfusion ECG-synchronized single-photon emissioncomputed tomography of the myocardium and coronaryangiography in the detection of coronary artery stenosis]. Vestnik Rossijskoj Voenno-medicinskoj akademii [Bulletin of the Russian Military medical Academy]. 2009; 4 (28): 10–16.

30. Nakanishi R, Gransar H, Slomka P, et al. Predictors of high-risk coronary artery disease in subjects with normal SPECT myocardial perfusion imaging. Journal of Nuclear Cardiology. 2016; 23 (3): 530-541.

31. Budoff MJ, Li D, Kazerooni EA, Thomas GS, Mieres JH, Shaw LJ. Diagnostic Accuracy of Noninvasive 64-row Computed Tomographic Coronary Angiography (CCTA) Compared with Myocardial Perfusion Imaging (MPI): The PICTURE Study, A Prospective Multicenter Trial. Academic Radiology. 2017; 24 (1): 22-29.

32. Yuan JW, Wang YT, Lu CZ. Coronary arteriography in thediagnosis results and prognosis analysis of suspectedcoronary artery disease in patients with normal SPET myocardial perfusion imaging. Hellenic Journal of Nuclear Medicine. 2015; 18 (3): 215-221.

33. Sumin AN, Korok EV, Korotkevich AA, et al. Vozmozhnosti odnofotonnoj emissonnoj komp’yuternoj tomografii v diagnostike obstruktivnyh porazhenij koronarnyh arterij [Possibilities of single-photonemission computed tomography in the diagnosisof obstructive lesions of the coronary arteries]. Rossijskij kardiologicheskij zhurnal [Russian journal of cardiology]. 2017; 12: 14-20.

 

UDC 616.127-005.8-08 (048.8)

DOI: 10.20969/VSKM.2020.13(3).47-51

PDF download THE IMPORTANCE OF CARDIO REHABILITATION COMBINED WITH PSYCHOLOGICAL CORRECTION FOR POST MYOCARIDAL INFARCTION PATIENTS

ZHITKOVA RENATA S., C. Med. Sci., associate professor of the Department of outpatient medicine and general medical practice of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. 8-937-628-62-17, e-mail: stelsy@mail.ru

KHALIULLINA DINARA R., VI year medical student of the faculty of general medicine of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. 8-917-885-47-53, e-mail: dinarakhaliullina796@gmail.com

AKHMETSHINA LEISAN A., VI year medical student of the faculty of general medicine of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. 8-987-216-03-15, e-mail: atlasovna19@gmail.com

SHARIPOVA REGINA R., VI year medical student of the faculty of general medicine of Kazan State Medical University, 420012, Russia, Kazan, Butlerov str., 49, tel. 8-939-395-19-88, e-mail: reymond.right@mail.ru

Abstract. The priority task of the health care is to select the most effective methods of prevention and treatment of cardiovascular diseases. One of the most important areas of this segment is cardio rehabilitation, which is a system of measures to improve the physical and mental health of the patient. Aim. The aim of the publication is to highlight theneed for psychological correction in patients who have suffered from myocardial infarction. Material and methods. A review of scienti c medical literature on cardio rehabilitation combined with psychological rehabilitation of the patients was performed. Results and discussion. The ndings of various studies suggest that the prognosis is unfavorable for most patients who have had myocardial infarction. Cardiovascular rehabilitation occupies a special place in the process of preventing early mortality after cardiovascular events. However, the importance of psycho correction along with physical rehabilitation is being stressed. Anxiety and depressive disorders, which are extremely common in patients with myocardial infarction, signi cantly worsen medical and psychosocial prognosis, and lead to a lower quality of life.Conclusion. Cardiorehabilitation should have a multidisciplinary approach aimed at improving the physical and mentalhealth of the patient. Psycho-correction can help to overcome the social maladaptation of the patient, to increase the feeling of control over the disease, to reduce depression and anxiety, to improve the long-term outcomes of physical and mental health, and to reduce mortality rates.

Key words: cardiac rehabilitation, multidisciplinary approach, psychological correction.

For reference: Zhitkova RS, Khaliullina DR, Akhmetshina LA, Sharipova RR. The importance of cardio rehabilitation combined with psychological correction in post myocardial infarction patients. The Bulletin of Contemporary Clinical Medicine. 2020; 13 (3): 47-51. DOI: 10.20969/VSKM.2020.13(3).47-51.

References

1. Artyunov GP, Rylova AK, Kolesnikova EA, et al. Kardioreabilitaciya [Cardiac rehabilitation]. MEDpress-inform. 2013; 335 p.

2. Marcevich SY, Ginzburg ML, Kutishenko NP, et al. Lyubereckoe issledovanie smertnosti: faktory, vliyayushchie na otdel’nyj prognoz zhizni posle perenesennogo infarkta miokarda [Lyubertsy mortality rates research:factors affecting prognosis of life after myocardialinfarction]. Profilakticheskaya medicina [Preventative medicine].2013; 16 (2): 32-38.

3. Aronov DM. Kardioreabilitaciya bol’nyh IBS: recept dlya Rossii [Cardiac rehabilitation of patients with ischemic heart disease: recipe for Russia]. Lechashchij vrach [Treating doctor]. 2007; 3: 6-22.

4. Bokeriya LA, Aronov DM. Koronarnoe shuntirovanie bol’nyh ishemicheskoj bolezn’yu serdca: reabilitaciya i vtorichnaya pro laktika [Coronary artery bypass grafting in patients with coronary heart disease: rehabilitation and secondary prevention]. KardioSomatika [CardioSomatica]. 2016; 7 (3): 5–71.

5. Jensen BO, Petersson K. The illness experiences of patients after a rst time myocardial infarction. Patient Education and Counseling. 2003; 51 (2): 31-123.

6. Hutton JM, Perkins SJ. A qualitative study of men’s experience of myocardial infarction. Psychology, Health & Medicine. 2008; 13 (3): 87–97.

7. Astin F, Horrocks J, Closs SJ. Managing lifestyle change to reduce coronary risk: a synthesis of qualitative research on peoples’ experiences. BMC Cardiovascular Disorders. 2014; 14 (6): 96.

8. Lane D, Carroll D, Ring C. The prevalence and persistence of depression and anxiety following myocardial infarction. British Journal of Health Psychology. 2002; 7 (1): 11–21.

9. Thombs BD, Bass EB, Ford DE, et al. Prevalence of Depression in Survivors of Acute Myocardial Infarction: Review of the Evidence. Journal of General Internal Medicine. 2006; 21 (1): 30–38.

10. Child A, et al. Meeting the psychological needs of cardiac patients: an integrated stepped-care approach within a cardiac rehabilitation setting. The British Journal of Cardiology. 2010; 17 (2): 79-175.

11. Roest AM, Martens EJ, Denollet J, et al. Prognosticassociation of anxiety post myocardial infarction withmortality and new cardiac events: a meta-analysis. Psychosom Med. 2010; 72 (6): 563–569.

  1. Feng HP, Chien WC, Cheng WT, et al. Risk of anxiety and depressive disorders in patients with myocardial infarction: A nationwide population-based cohort study. Medicine. 2016; 95 (34): 463-464.

  2. Kornetov NA, Lebedeva EV. Depressivnye rasstrojstva u pacientov, perenyosshih infarkt miokarda [Depressive disorders in post myocardial infarction patients]. Psihiatriya i psihofarmakoterapiya [Psychiatry and psychopharmacotherapy]. 2003; 5 (5): 195–198.

  3. Richards SH, Anderson L, Jenkinson CE, et al. Psychological interventions for coronary heart disease. Cochrane Database Systematic Review and meta-analysis. 2017; 4 (4): CD002902.

  4. Lichtman JH, Froelicher ES, Blumenthal JA, et al. Depression as a risk factor for poor prognosis among patients with acute coronary syndrome: systematic review and recommendations: a scienti c statement from the American heart association. Circulation. 2014; 129 (12): 1350–1369.

  5. Sin NL, Kumar AD, Gehi AK, et al. Direction of Association Between Depressive Symptoms and Lifestyle Behaviors in Patients with Coronary Heart Disease: The Heart and Soul Stud. Annals of behavioral medicine. 2016; 50 (4): 523–532.

  6. Meijer A, Conradi HJ, Bos EH, et al. Prognostic associationof depression following myocardial infarction with mortalityand cardiovascular events: a meta-analysis of 25 years of research. Gen Hosp Psychiatry. 2011; 33 (3): 203–216.

  7. Linden W, Phillips MJ, Leclerc J. Psychological treatment of cardiac patients: a meta-analysis. Eur Heart J. 2007; 28 (24): 2972-2984.

  8. Adams P, Benett I, Carver K, Cunningham W, et al. MI – Secondary Prevention: Secondary Prevention in Primary and Secondary Care for Patients Following a Myocardial Infarction. London: Royal College of Physicians (UK). 2013; 604 p.

20. Kaptein AA, Scharloo M, Helder DI, Kleijn WC, Van Koorlaar IM, Woertman M. Representation of chronic illnesses; in: LD Cameron, H Leventhal (Eds); The self-regulation of health and illness behaviour. Routledge: London. 2003; 8 (2): 97-118.

21. 21.Hoffman BM, Papas RK, Chatkoff DK, Kerns RD. Meta-analysis of psychological interventions for chronic low back pain. Health Psychol. 2007; 26 (1): 1-9.

22. Solodukhin AV, Seryi AV, Yanitskiy MS, Trubnikova OA. Vozmozhnosti metodov kognitivno-povedencheskoj psihoterapii v izmenenii vnutrennej kartiny bolezni u pacientov s ishemicheskoj bolezn’yu serdca [Cognitive behavioral therapy: an option for changing internal picture of disease in patients with coronary artery desease]. Fundamental’naya i klinicheskaya medicina [Fundamental and clinical medicine]. 2017; 2 (2): 87-88.

23. Michie S, Connor D, Bath J, et al. Cardiac rehabilitation:The psychological changes that predict health outcomeand healthy behavior. Psychology, Health & Medicine. 2005; 10 (1): 88 – 95.

24. Petrie KJ, Weinman J, Sharpe N, Buckley J. Role of patients’ view of their illness in predicting return to work and functioning after myocardial infarction: longitudinal study. BMJ. 1996; 312 (7040): 1191-1194.

25. Petrie KJ, Cameron LD, Ellis CJ, Buick D, Weinman J. Changing illness perceptions after myocardial infarction: an early intervention randomized controlled trial. Psychosom Med. 2002; 64 (4): 580-586.

26. Prevedini AB, Presti G, Rabitti E, Miselli G, Moderato P. Acceptance and commitment therapy (ACT): thefoundation of the therapeutic model and an overview of its contribution to the treatment of patients with chronicphysical diseases. G Ital Med Lav Ergon. 2011; 33 (1): 53-63.

 

UDC 615.28:616-089.165.4(048.8)

DOI: 10.20969/VSKM.2020.13(3).51-58

PDF download MODERN ANTISEPTICS IN SURGICAL AREA MANIPULATION

MOROZOV ARTEM M., ORCID ID: 0000-0003-4213-5379; SCOPUS Author ID: 773117; C. Med. Sci., assistant of professor of the Department of general surgery of Tver State Medical University, Russia, 170100, Tver, Sovetskaya str., 4, e-mail ammorozovv@gmail.com

SERGEEV ALEKSEY N., ORCID ID: 0000-0002-9657-8063; SCOPUS Author ID: 817840; D. Med. Sci., associate professor of the Department of general surgery of Tver State Medical University, Russia, 170100, Tver, Sovetskaya str., 4, e-mail: dr.nikolaevich@mail.ru

KADYKOV VIKTOR A., ORCID ID: 0000-0002-7516-3467; SCOPUS Author ID: 734399; C. Med. Sci., associate professor of the Department of general surgery of Tver State Medical University, Russia, 170100, Tver, Sovetskaya str., 4, e-mail: ammorozovv@gmail.com

ASKEROV ELSHAD M., ORCID ID: 0000-0002-2567-6088; SCOPUS Author ID: 1039303; C. Med. Sci., associate professor of the Department of general surgery of Tver State Medical University, Russia, 170100, Tver, Sovetskaya str., 4, e-mail: ammorozovv@gmail.com

ZHUKOV SERGEY V., ORCID ID: 0000-0002-3145-9776; SCOPUS Author ID: 210092; D. Med. Sci., associate professor of the Department of public health and health management with a history of medicine course of Tver State Medical University, Russia, 170100, Tver, Sovetskaya str., 4, e-mail: ammorozovv@gmail.com

PELTIKHINA OLGA V., ORCID ID: 0000-0003-4555-0439; SCOPUS Author ID: 3816-6700; 5th year student of pediatric faculty of Tver State Medical University, Russia, 170100, Tver, Sovetskaya str., 4, e-mail: cola1072008@yandex.ru

PICHUGOVA ANASTASIA N., ORCID ID: 0000-0001-8892-7086; SCOPUS Author ID: 6917-7060; 3rd year student of faculty of general medicine of Tver State Medical University, Russia, 170100, Tver, Sovetskaya str., 4, e-mail: nastya@indek.ru

Abstract. Aim. The aim of the study was to determine the effectiveness of the existing methods of the surgical area manipulation. The objectives of the study are to assess their positive and negative characteristics; and to study the latest developments in the eld. Material and methods. Compilation of modern Russian and foreign literary sources, as well as the latest scienti c papers on modern aseptics and antiseptics were reviewed. Results and discussion. Currently, the preparation of the surgical area for surgical intervention is presented by 4 stages. This technique is universal and in various cases it differs only in the disinfectant used, which may belong to one of the following groups of antiseptics: halogens and halogen-containing compounds, metal salts, detergents, dyes, oxidizing agents, acids and alkalis, alcohols and aldehydes and others. In modern surgical practice, such antiseptic agents as povidone iodine, diamond green, ethyl, propyl and isopropyl alcohols, chlorhexidine, and degmicide are widely used. Each of the above drugs is characterized by a wide range of bactericidal activity. Some substances demonstrate antiviral and fungicidal effect. However, the presence of a number of negative side effects limits the use of these antiseptics. The progress in pharmacology, chemistry and nanotechnology has contributed to signi cant advances in the development and use of new antiseptic drugs in surgical practice. At present, combined antiseptics are being actively used, which makes it possible to cover up the negative effects of their components. The possibility of using silver nanoparticles and nitrogen monoxide as antiseptics is being studied. Polymeric medical lms are being developed. Conclusion. To date, the issue of prevention of postsurgical infection caused by the surgery remains a relevant one. The antiseptic agents used nowadays are represented by a wide range of chemical compounds possessing a number of positive and negative characteristics. The problem of creation of antiseptic agent characterized by the absence of adverse side effects encourages searching for the new means and methods of surgical area manipulation. Promising trends are studying the possibility of nanoparticles application, studying the properties and characteristics of polymer lms and others, but the challenge of introducing the latest developments into medical practice persists.

Key words: antiseptics, aseptics, surgical area, antiseptic agents.

For reference: Morozov AM, Sergeev AN, Kadykov VA, Askerov EM, Zhukov SV, Peltikhina OV, Pichugova AN. Modern antiseptics in surgical area manipulation. The Bulletin of Contemporary Clinical Medicine. 2020; 13 (3): 51-58. DOI: 10.20969/VSKM.2020.13(3).51-58.

References

  1. Korejba KA, et al. Antibiotikoterapija u bol’nyh s infekciej kozhi i mjagkih tkanej v posleoperacionnom periode [Antibiotic therapy in patients with infection of the skin and soft tissues in the postoperative period]. Kazanskij medicinskij zhurnal [Kazan Medical Journal]. 2011; 92 (2): 187-190.

  2. Federal’nye klinicheskie rekomendacii [Federal clinical guidelines]. Jepidemiologicheskoe nabljudenie za infekcijami, svjazannymi s okazaniem medicinskoj pomoshhi [Epidemiological surveillance of infections associated with the provision of medical care]. Moskva [Moskva]. 2014; 58 p. http://nasci.ru/?id=3372

  3. Morozov AM, Mohov EM, Kadykov VA, Panova AV. Medicinskaya termogra ya: vozmozhnosti i perspektivy [Medical thermography: opportunities and prospects]. Kazanskij medicinskij zhurnal [Kazan Medical Journal]. 2018; 99 (2): 264-270.

  4. Morozov AM, et al. Vozmozhnosti razrabotki novogo biologicheski aktivnogo shovnogo materiala v hirurgii (obzor literatury) [Possibilities of developing a new biologically active suture material in surgery (literature review)]. Vestnik eksperimental’noj i klinicheskoj hirurgii [Bulletin of experimental and clinical surgery]. 2019; 12 (3): 193-198.

  5. Kvashnina DV, Kovalishena OV. Ocenka primenenija hlorgeksidina kak antisepticheskogo sredstva [Evaluation of the use of chlorhexidine as an antiseptic] // Medicinskij Al’manah [Medical Almanac]. 2016; 43, 3(43): 62-66.

  6. Opimah IV. Istorija antiseptiki – bor’ba idej, chestoljubija, ambicij... [The history of antiseptics is a struggle of ideas, ambition, ambition ...]. Medicinskie tehnologii [Medical technology]. 2010; 2: 74-80.

  7. Ruseckij JuJu, Sedyh TK. Obrabotka operacionnogo polja v oblasti limfoidno-glotochnogo kol’ca [Processing the surgical eld in the area of the lymphoid-pharyngeal ring]. Kremlevskaja medicina; Klinicheskij vestnik [Kremlin medicine; Clinical Herald]. 2013; 1: 63-68.

  8. Torretta S, Drago L, Marchisio P, et al. Otolarygol Head Neck Surg. 2011; 144: 784-788.

  9. Jolivet S, et al. Surgical eld and skin preparation. Orthop Traumatol Surg Res. 2019; 105 (1S): S1-S6.

  10. Barsukov AN, Agafonov OI, Afanas’ev DV. Primenenie povidon-joda v pro laktike infekcij oblasti hirurgicheskogo vmeshatel’stva [The use of povidone iodine in the prevention of infections of the surgical area]. Russkij

medicinskij zhurnal; Medicinskoe obozrenie [Russian Medical Journal; Medical Review]. 2018; 2 (12): 7-11.

11. Registr lekarstvennyh sredstv Rossii; RLS; 2000-2020 [Register of medicines of Russia. Radar; 2000-2020]. https://pda.rlsnet.ru/

12. Volkova SV, Klementenok EV. Dostoinstva i nedostatki sovremennyh kozhnyh antiseptikov [Advantages and disadvantages of modern skin antiseptics]. Klinika [Clinic]. 2011; 3: 148-149.

13. Gostishhev VK. Obshhaja hirurgija: uchebnik [General Surgery: textbook]. Moskva: GJeOTAR-Media [Moscow: GEOTAR-Media]. 2015; 5: 54 p.

14. Tihomirov AL, Sarsanija SI, Tuskaev KS. Aktual’nost’ primenenija povidon-joda v praktike akushera-ginekologa [The relevance of using povidone iodine in the practice of an obstetrician-gynecologist]. Rossiyskiy meditsinskiy zhurnal; Mat’ i ditya [Russian Medical Journal; Mother and Child]. 2014; 1: 50.

15. Chernjakov AV. Sovremennye antiseptiki i hirurgicheskie aspekty ih primenenija [Modern antiseptics and surgical aspects of their use]. Rossiyskiy meditsinskiy zhurnal [Russian Medical Journal]. 2017; 28: 2059-2062.

16. Adamenko GV, Burak II, Miklis NI. Gigienicheskaja ocenka kombinirovannyh spirtosoderzhashhih antiseptikov [Hygienic assessment of combined alcohol-containing antiseptics]. Zdorov’e i okruzhajushhaja sreda [Health and the environment]. 2014; 1 (24): 151-154.

17. Bidevkina MV, et al. Sravnitel’naja toksichnost’ nekotoryh spirtov i kozhnyh antiseptikov na ih osnove [Comparative toxicity of some alcohols and skin antiseptics based on them]. Toksikologicheskij vestnik [Toxicological Bulletin]. 2016; 2 (137): 19-24.

18. Melkumjan AS. Znachenie sredstv antiseptiki i taktika ih vybora v pro laktike vnutribol’nichnyh infekcij [Theimportance of antiseptic agents and the tactics oftheir choice in the prevention of nosocomial infec-tions]. Medicinskaja sestra [Nurse]. 2010; 6: 44-45.

19. Gluhov AA, Andreev AA, Bolotskih VI. Osnovy uhoda za hirurgicheskimi bol’nymi: uchebnoe posobie [Funda-mentals of the care of surgical patient: a training manual]. Moskva: GJeOTAR-Media [Moscow: GEOTAR-Media]. 2017; 288 p.

20. Adamenko GV, Burak II. Tehnologija poluchenija kombinirovannogo antisepticheskogo lekarstvennogo sredstva «Vitasept-SKZ» [The technology for producing a combined antiseptic drug “Vitasept-SKZ”]. Vestnik farmacii [Bulletin of pharmacy]. 2014; 1: 10-16.

21. Jurchenko SA. Primenenie operacionnyh razrezaemyh plenok kak mera predotvrashhenija vnutribol’nichnyh infekcij [The use of surgical cut lms as a measure to prevent nosocomial infections]. Medicinskaja sestra [Nurse]. 2010; 2: 13-14.

22. Operacionnye razrezaemye plenki: sajt 3MTM [Operating cut lms: 3M TM site]. Jelektronnyj resurs [Electronic resource]. URL: https://www.3mrussia.ru/3M/ru_RU/ company-ru

23. Nizamova IM, Hazeeva JeA, Galimzjanlva RJu. Analiz vidov operacionnyh razrezaemyh plenok [Analysis of types of operational cut lms]. Nauchno-prakticheskoj jelektronnyj zhurnal Alleja Nauki [Scientific-practical electronic journal Alley of Science]. 2018; 11: 107-111.

24. Andreev VA. Antibakterial’naja aktivnost’ tradicionnyh i nanoantiseptikov, perspektiva ih absorbcii na ranevyh pokrytijah [Antibacterial activity of traditional and nanoantiseptics, the prospect of their absorption on wound dressings]. Vestnik Rossijskoj voenno-medicinskoj akademii [Bulletin of the Russian Military Medical Academ]. 2012; 3 (39): 173-177.

25. Bukina JuA, Sergeeva EA. Antibakterial’nye svojstva i mehanizm baktericidnogo dejstvija nanochastic i ionov serebra [Antibacterial properties and bactericidal mechanism of silver nanoparticles and ions]. Vestnik Kazanskogo tehnologicheskogo universiteta [Bulletin of Kazan Technological University]. 2012; 14: 170-172.

  1. Larichev AB, et al. Osobennosti reparativnoj regeneracii pri zazhivlenii asepticheskoj rany pri razlichnyh sposobah podgotovki operacionnogo polja v uslovijah jeksperimenta [Features of reparative regeneration during the healing ofan aseptic wound with various methods of preparation ofthe surgical eld under experimental conditions]. Morfologija [Morphology]. 2014; 146 (6): 97-101.

  2. Lisovskij AV. Preventivnye vozmozhnosti jekzogennogo monooksida azota i limfotropnoj antibiotikopro laktiki v planovoj abdominal’noj hirurgii [Preventive possibilitiesof exogenous nitric monoxide and lymphotropic antibioticprophylaxis in planned abdominal surgery]. Yaroslavl’: Yaroslavskaya gosudarstvennaya meditsinskaya akademiya [Yaroslavl: Yaroslavl State Medical Academy]. 2010; 22 p.

28. Kuznecova VL, Solov’eva AG. Oksid azota: svojstva, biologicheskaja rol’, mehanizmy dejstvija [Nitric oxide: properties, biological role, mechanisms of action]. Sovremennye problemy nauki i obrazovanija [Modern problems of science and education]. 2015; 4: URL: http://www.science-education.ru/ru/article/ view?id=21037.

 

UDC 616.24-036.12-085.357.453.032.23(048.8)

DOI: 10.20969/VSKM.2020.13(3).58-63

PDF download INHALED GLUCOCORTICOSTEROIDS AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A REVIEW OF THE CONCEPT

KHAMITOV RUSTEM F., ORCID ID: 0000-0001-8821-0421; D. Med. Sci., professor, the Head of the Department of internal medicine of Kazan State Medical University; Chief freelance specialist-pulmonologist at the Kazan Institute of Health of the Republic of Tatarstan, Russia, 420012, Kazan, Butlerov str., 39, tel. +7-917-272-96-72, e-mail: rhamitov@mail.ru

VIZEL ALEXANDER A., ORCID ID: 0000-0001-5028-5276; D. Med. Sci., professor, the Head of the Department of phthisiopulmonology of Kazan State Medical University; Chief freelance pulmonologist of the Ministry of Health of the Republic of Tatarstan, Russia, 420012, Kazan, Butlerov str., 39, tel. +7-987-296-25-99, e-mail: lordara@inbox.ru

ZHESTKOV ALEXANDER V., ORCID ID: 0000-0002-3960-830; D. Med. Sci., professor, the Head of the Department of microbiology, immunology and allergy of Samara State Medical University; Chief freelance pulmonologist of the Volga Federal District, Russia, Samara, Chapaevskaya str., 89, tel. +7-987-445-14-90, e-mail: avzhestkov2015@yandex.ru

BOGDANOVA JULIA V., C. Med. Sci., the Head of the Department of pulmonology of Samara Regional Clinical Hospital named after V.D. Seredavin; Chief freelance pulmonologist of the Samara region, Russia, 443095, Samara, Tashkentskaya str., 159, tel. +7-927-298-03-03, e-mail: svd70@list.ru

GALUSHINA IRINA A., C. Med. Sci., the Head of the Department of pulmonology of Ulyanovsk Regional Clinical Hospital; Chief freelance pulmonologist of Ulyanovsk region, Russia, 432017, Ul’yanovsk, Tretyi Internatsional str., 7, tel. +7-929-792-02-34, e-mail: galushinairina@yandex.ru

ZVEREVA ELENA V., pulmonologist of the Department of pulmonology of Kirov City Hospital No 2; Chief freelance pulmonologist of the Kirov region, Russia, 610008, Kirov, Gagarin str., 2, tel. +7-912-827-27-76, e-mail: ena.zvereva72@mail.ru

ZULKARNEEV RUSTEM KH., D. Med. Sci., professor, professor of the Department of introduction to internal medicine of Bashkir State Medical University; Chief freelance specialist of the Republic of Bashkortostan, Russia, Ufa, Lenin str., 3, tel. +7-917-420-69-25, e-mail: zurustem@mail.ru

KULBAISOV AMYRZHAN M., C. Med. Sci., the Head of the Department of pulmonology of Orenburg Regional Clinical Hospital No 2; Chief freelance pulmonologist of Orenburg region, Russia, 460000, Orenburg, Nevelskaya str., 24, tel. +7-903-360-89-74, e-mail: kul60@yandex.ru

MISHLANOV VITALY YU., ORCID ID: 0000-0001-5028-5276; D. Med. Sci., professor, corresponding member of the Russian Academy of Sciences, the Head of the Department of introduction to internal medicine No 1 of Perm State Medical University named after academician E.A. Wagner; Chief freelance pulmonologist of the Perm region, Russia, Perm, Kuibyshev str., 39, tel. +7-950-467-76-96, e-mail: permmed@hotmail.com

PAVLOV PETER I., the Head of the Department of pulmonology Republican Clinical Hospital of the Ministry of health of the Chuvash Republic; Chief freelance pulmonologist of Chuvash Republic, Russia, 428018, Cheboksary, Moskovsky av., 9, tel. +7-927-854-72-24, e-mail: pi_pavlov@mail.ru

SUSHENTSOV VADIM G., pulmonologist of Medical Unit No 1 of the Republic of Mari El, Russia, 424037, Yoshkar-Ola, Vodoprovodnaya str., 83b, +7-937-939-38-32, e-mail: vadiksushentsov@mail.ru

STARODUBTSEVA OKSANA I., C. Med. Sci., the Head of the Department of pulmonology First Republican Clinical Hospital of the Ministry of Health of Udmurtia Republic; Chief freelance pulmonologist of the Republic of Udmurtia, Russia, 426039, Izhevsk, Votkinsk highway, 57, tel. +7-912-458-70-56, e-mail: staroduboksan@mail.ru

STESHENKO RUSLAN N., C. Med. Sci., the Head of the Department of pulmonology Saratov Regional Clinical Hospital; Chief freelance pulmonoogist of the Saratov region, Russia, 410053, Saratov, Smirnov Gorge microdistrict, building 1, block 1, tel. +7-927-629-31-93, e-mail: steshensaratov@mail.ru

FEDOTOV VASILY D., ORCID ID: 0000-0003-4307-9321; C. Med. Sci., assistant of professor of the Department of advanced internal medicine named after V.G. Vogralik of Volga Research Medical University; Chief freelance pulmonologist of Nizhny Novgorod region, Russia, 603005, Nizhny Novgorod, Minin and Pozharsky square, 10/1, tel. +7-920-014-61-06, e-mail: basil11@yandex.ru

Аbstract. Aim. Revision of the concept of inhaled glucocorticosteroids administration in chronic obstructive pulmonary disease. Material and methods. Conclusion of the Council of Experts. Results and discussion. Chronic obstructive pulmonary disease is a very common disease and has a signi cant impact on patient survival, as well as a signi cant economic loss to health care. First of all, such losses are determined by exacerbations of chronic obstructive pulmonary disease, especially severe ones requiring hospitalization. The development of understanding of the mechanisms of exacerbations of chronic obstructive pulmonary disease will make it possible to optimize the application of existing and new interventions for prevention and treatment of these conditions. Possibilities of practical use of biomarkers allowing personalizing prescription of inhaled glucocorticosteroids to patients with chronic obstructive pulmonary disease and algorithms of withdrawal of this group of drugs with their substitution by modern double bronchodilators are being discussed. Conclusion. The Council of Experts concluded that, when prescribing inhaled glucocorticosteroids in patients with chronic obstructive pulmonary disease without asthma, it is recommended to consider peripheral blood eosinophilic counts higher than 300 kl/μl, which persist in two studies performed at intervals of 4–6 weeks, at least 3 weeks after exacerbation. In addition to eosinophilic counts, the decision on whether to continue or discontinue glucocorticosteroid inhalation therapy should be in uenced by the assessment of the initially elevated risk of infections (including fungal and viral), pneumonia, diabetes mellitus, osteoporosis and fractures in the history, tuberculosis, and bronchoectasia (especially with the release of Pseudomonas aeruginosa).

Key words: chronic obstructive pulmonary disease, inhaled corticosteroids, double bronchodilators.

For reference: Khamitov RF, Vizel AA, Zhestkov AV, Bogdanova JuV, Galushina IA, Zvereva EV, Zulkarneev RKh, Kulbaisov AM, Mishlanov VYu, Pavlov PI, Sushentsov VG, Starodubtseva OI, Steshenko RN, Fedotov VD. Inhaled corticosteroids and chronic obstructive pulmonary disease: a review of the concept. The Bulletin of Contemporary Clinical Medicine. 2020; 13 (3): 58-63. DOI: 10.20969/VSKM.2020.13(3).58-63.

References

1. Global Initiative for Chronic Obstructive Lung Disease. Global Strategy for Prevention, Diagnosis and Management of COPD. GOLD Reports. 2019; https://goldcopd. org/gold-reports/

2. Lozano R, Naghavi M, Foreman K, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012; 380: 2095-2128. DOI: 10.1016/S0140-6736(12)61728-0

3. Pavord ID, Jones PW, Pierre-Régis Burgel, Rabe KF. Exacerbations of COPD. Int J Chron Obstruct Pulmon Dis. 2016; 11: 21–30. DOI: 10.2147/COPD.S85978.

4. Sethi S, Murphy TF. Infection in the pathogenesis and course of chronic obstructive pulmonary disease. N Engl J Med. 2008; 359 (22): 2355-2365.

5. Wedzicha JA, Brill SE, Allinson JP, Donaldson GC.Mechanisms and impact of the frequent exacerbatorphenotype in chronic obstructive pulmonary disease. BMC Med. 2013; 11: 181.

6. Groenewegen KH, Postma DS, Hop WC, Wielders PL, Schlösser NJ, Wouters EF, COSMIC Study Group. Increased systemic in ammation is a risk factor for COPD exacerbations. Chest. 2008; 133 (2): 350-357.

  1. Brightling CE, Monteiro W, Ward R, Parker D, Morgan MD, Wardlaw AJ, Pavord ID. Sputum eosinophilia and short-term response to prednisolone in chronic obstructivepulmonarydisease:arandomisedcontrolledtrial.Lancet. 2000; 356 (9240): 1480-1485.

  2. Avdeev S, Aisanov Z, Arkhipov V, Belevskiy A, Leshchenko I, Ovcharenko S, Shmelev E, Miravitlles M. Otmena ingalyacionnich glykokortikosteroidov y patientov s chronocheskoy obstruktivnoi bolezni lyegkih [Withdrawal of inhaled glucocorticosteroids in patients with chronic obstructive pulmonary disease]. Pulmonologya [Pulmonology]. 2019; 29 (3): 334–345. DOI: 10.18093/0869-0189-2019-29-3-334-345.

  3. Avdeev S, Aisanov Z, Arkhipov V, Belevskiy A, Leshchenko I, Ovcharenko S, Shmelev E, Miravitlles M. Withdrawal of inhaled corticosteroids in COPD patients: rationale and algorithms. International Journal of Chronic Obstructive Pulmonary Disease. 2019; 14: 1267–1280.

  4. Ye W, Guo X, Yang T, Han F. Systematic review of inhaledcorticosteroid withdrawal effects in chronic obstructivepulmonary disease, and comparison with two «real-life» studies. J Thorac Dis. 2018; 10 (7): 4565-4573. DOI: 10.21037/jtd.2018.06.151.

  5. Magnussen H, Disse B, Rodriguez-Roisin R, et al.Withdrawal of inhaled glucocorticoids and exacerbationsof COPD. N Engl J Med. 2014; 371: 1285-1294. DOI: 10.1056/NEJMoa1407154/

  6. Buhl R, Criée CP, Kardos P, Vogelmeier CF, Kostikas K, Lossi NS, Worth H. Dual bronchodilation vs triple therapy in the «real-life» COPD DACCORD study. Int J Chron Obstruct Pulmon Dis. 2018; 13: 2557-2568.

  7. Vogelmeier CF, Criner GJ, Martinez FJ, et al. Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary. Respirology. 2017; 22: 575-601. DOI: 10.1111/resp.13012.

  8. DeromE,BrusselleGG,JoosGF.Ef cacyoftiotropium– olodaterol xed-dose combination in COPD. Int J Chron Obstruct Pulmon Dis. 2016; 11: 3163–3177. DOI: 10.2147/ COPD.S92840.

  9. Avdeev S, Aisanov Z, Belevskiy A, Zyikov K, Leshchenko I, Ovcharenko S, Shmelev E, Arhipov V, Gorblyanskii U, Emelyanov A, Ignatova G, Kazantsev V, Karoli N, Kolbasnikov S, Kudelya L, Kuzubova N, Sinopalnikov A, Stepanyan I, Trofimenko I, Fassahov R, Hamitov R, Shaporova N. Mesto xirovannoi kombinacii bronhodilatatororv dlitelnogo deistviya tiotropii/olodaterol v startovoi terapii chronocheskoy obstruktivnoi bolezni lyegkih; zakluchenie Soveta expertov Rossiiskogo respiratornogo obschestva [The place of a xed combination of long-acting bronchodilators tiotropium/ olodaterol in the initial therapy of chronic obstructive pulmonary disease; conclusion of the expert Council of the Russian respiratory society]. Pulmonologya [Pulmonology]. 2016; 26 (4): 505-513.
  10. Horita N, Goto A, Shibata Y, Ota E, Nakashima K, Nagai K, Kaneko T. Long-acting muscarinic antagonist (LAMA) plus long-acting beta-agonist (LABA) versus LABA plus inhaled corticosteroid (ICS) for stable chronic obstructive pulmonary disease (COPD). Cochrane Database Syst Rev. 2017; 2: CD012066. DOI: 10.1002/14651858. CD012066.pub2
  11. Oba Y, Keeney E, Ghatehorde N, Dias S. Dual combination therapy versus long-acting bronchodilators alone for chronic obstructive pulmonary disease (COPD): a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2018; 12: CD012620. DOI: 10.1002/14651858. CD012620.pub2.

 

UDC 616.24-001.28-02:615.849(048.8)

DOI: 10.20969/VSKM.2020.13(3). 63-73

PDF download RADIATION-INDUCED LUNG INJURY. A REVIEW

SHAYMURATOV RUSTEM I., ORCID ID: 0000-0002-5940-1656; Web of Science Researcher ID: Q-3122-2019; C. Med. Sci., assistant of professor of the Department of phthisiopulmonology of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, e-mail: russtem@gmail.com

Abstract. Radiation-induced lung injury (RILI) is one of the common complications of radiation therapy. Aim. Thepresent review summarizes knowledge about the latest data on epidemiology, pathogenesis, diagnosis, and treatment of patients with radiation-induced lung damage. Materials and methods. Data were collected from PubMed, Elibrary databases and by general search queries. Results and its discussion. Radiation-induced lung injury is a common, severe and in some cases fatal complication of radiation therapy, leading to a decrease in the quality of life of cancer patients. The increasing cancer burden correlate with increased incidence of RILI. Epidemiological data shows that RILI is frequently misdiagnosed. There are no approved guidelines for the treatment and management of RILI. A well-known radioprotection and novel molecules have not been tested in prospective randomized controlled clinical trials.Conclusion. Despite, radiation-induced lung damage has been well studied in experimental models and in clinical observations, there are some diagnostic and management uncertainties require further research.

Key words: radiation-induced lung injury, diagnosis, prognosis, risk factors, treatment.

For reference: Shaymuratov RI. Radiation-Induced Lung Injury. A Review. The Bulletin of Contemporary Clinical Medicine. 2020; 13(3): 63-73. DOI: 10.20969/VSKM.2020.13(3).63-73.

References

  1. Underwood E.A. Wilhelm Conrad Röntgen (1845-1923) and the Early Development of Radiology / E A Underwood // Proc. R. Soc. Med. – 1945. – Vol. 38. – N. 12. – P. 697-706.
  2. Progress in Radiotherapy / No authors listed // Hospital (Lond 1886). – 1903. – Vol. 33. – N. 855. P - 338-339.
  3. Flockerzi E., Schanz S., Rübe C.E. Even low doses of radiation lead to DNA damage accumulation in lung tissue according to the genetically-defined DNA repair capacity / E. Flockerzi, S. Schanz, C.E. Rübe // Radiother Oncol. – 2014. – Vol. – 111. – N. – 2. – P. 212-218.
  4. Groover T.A., Christle A.C., Merritt E.A. Observations on the use of the copperfilter in the roentgen treatment of deep-seated malignancies / T.A. Groover, A.C. Christle, E.A. Merritt E.A. // South. Med. J. – 1922. – Vol. – 15. – P. 440-444.
  5. Downs E.E. Lung changes subsequent to irradiation in cancer of the breast / E.E. Downs // Am. J. Roentgenol. – 1936. – Vol. 36. – P. 61-64.
  6. Warren, S., Spencer, J. Radiation reaction in the lung. / S. Warren, J. Spencer // Am. J. Roentgenol. – 1940. – Vol. 43. – P.682-701.
  7. МРНЦ – 50 лет: клинический радиологический сектор (прошлое и настоящее) / Б.А. Бердов [и др.] // Радиация и риск. – 2012. – Том 21. - № 3. – С. 23-40.

Berdov BA et al. MRNTS – 50 let: klinicheskiy radiologicheskiy sektor (proshloye i nastoyashcheye) [MRSC 50thanniversary. Clinical and radiological section (past and present)] / Radiatsiya i risk. 2012; 21(3):23-40.

  1. Clinical and Functional Assays of Radiosensitivity and Radiation-Induced Second Cancer / Habash M [et al.] // Cancers (Basel). – 2017. – Vol. 9. – N 11. P. 147.
  2. The protective effect of amifostine on radiation-induced acute pulmonary toxicity: Detection by 99mTc-DTPA transalveolar clearances / C. Uzal [et al.] // Int. J. Radiation Oncology Biol. Phys. – 2004. – Vol. 60. – N. 2. P. 564–569.
  3. On the use of published radiobiological parameters and the evaluation of NTCP models regarding lung pneumonitis in clinical breast radiotherapy / P. Svolos [et al.] // Australas. Phys. Eng. Sci. Med. – 2011. – Vol. 34. – N 1. – P. 69-81.
  4. Lung abnormalities at multimodality imaging after radiation therapy for non-small cell lung cancer / A.R. Larici [et al.] // Radiographics. – 2011. – Vol. 31. – N 3. – P. 771-789.
  5. A case of radiation recall pneumonitis induced by erlotinib, which can be related to high plasma concentration / Y Togashi [et al.] // J. Thorac. Oncol. – 2010. – Vol. 5. – N. 6. – P. 924-925.
  6. Radiation recall pneumonitis caused by erlotinib after palliative definitive radiotherapy / C. Onal [et al.] // Onkologie. – 2012. – Vol. 35. – N. 4. – P. 191-194.
  7. Positron emission tomography demonstrates radiation-induced changes to nonirradiated lungs in lung cancer patients treated with radiation and chemotherapy / H.A. Hassaballa // Chest. – 2005. – Vol. 128. – N 3. – P. 1448-1452.
  8. Challenges in defining radiation pneumonitis in patients with lung cancer / Z Kocak [et al.] // Int. J. Radiat. Oncol. Biol. Phys. 2005;62(3):635-638.
  9. Huang K., Palma D.A. IASLC Advanced Radiation Technology Committee. Follow-up of patients after stereotactic radiation for lung cancer: a primer for the nonradiation oncologist / K. Huang, D.A. Palma // J. Thorac. Oncol. – 2015. – Vol. 10. – N 3. – P. 412-419.
  10. Anscher M.S. The irreversibility of radiation-induced fibrosis: fact or folklore?. / M.S. Anscher // J. Clin. Oncol. – 2005. – Vol. 23. – N. 34. – P. 8551-8552.
  11. Clinical dose-volume histogram analysis for pneumonitis after 3D treatment for non-small cell lung cancer (NSCLC) / M.V. Graham [et al.] // Int. J. Radiat. Oncol. Biol. Phys. – 1999. – Vol. 45. – N. 2. – P.323-329.
  12. НаркевичБ.Я. Радиационная безопасность в рентгенодиагностике и интервенционной радиологии / Б.Я. Наркевич, Б.И. Долгушин // Диагностическая интервенционная радиология. – 2009. – Том 3. – № 2. – С. 67–76.

Narkevich BY, Dolgushin BI Radiatsionnaya bezopasnost' v rentgenodiagnostike i interventsionnoy radiologii [Radiation safety in X-ray diagnostics and interventional radiology] Diagnosticheskaya interventsionnaya radiologiya [Diagnostic interventional radiology]. 2009;3(2):67-76.

  1. Radiation-induced lung disease and the impact of radiation methods on imaging features / K.J. Park [et al.] // Radiographics. – 2000. – Vol. 20. – N. 1. – P. 83-98.
  2. Randomized phase III trial of radiation treatment +/- amifostine in patients with advanced-stage lung cancer [published correction appears in Int J Radiat Oncol Biol Phys 2002 Apr 1;52(5):1458] [published correction appears in Int J Radiat Oncol Biol Phys 2002 Sep 1;54(1):308] / D. Antonadou [et al.] // Int. J. Radiat. Oncol. Biol. Phys. – 2001. – Vol. 51. – N 4. – P. 915-922.
  3. Reckzeh B, Merte H, Pflüger KH, Pfab R, Wolf M, Havemann K. Severe lymphocytopenia and interstitial pneumonia in patients treated with paclitaxel and simultaneous radiotherapy for non-small-cell lung cancer / B. Reckzeh [et al.] // J. Clin. Oncol. – 1996. – Vol. 14. – N 4. – P.1071-1076.
  4. Radiation-Induced Lung Injury: Assessment and Management / A.N. Hanania [et al.] // Chest. – 2019. – Vol. 156. – N 1. – P. 150-162.
  5. Predicting radiation pneumonitis after chemoradiation therapy for lung cancer: an international individual patient data meta-analysis / D.A. Palma [et al.] // Int. J. Radiat. Oncol. Biol. Phys. – 2013. – Vol. 85. – N 2. – P. 444-450.
  6. Trends in Radiation Therapy among Cancer Survivors in the United States, 2000-2030. / A.K. Bryant [et al.] // Cancer Epidemiol Biomarkers Prev. – 2017. – Vol. 26. – N 6. – P. 963-970.
  7. Incidence of organizing pneumonia after whole-breast radiotherapy for breast cancer, and risk factor analysis / H. Sato [et al.] // J. Radiat. Res. – 2018. – Vol. 59. – N 3. – P. 298-302.
  8. Vasiljevic D, Arnold C, Neuman D, et al. Occurrence of pneumonitis following radiotherapy of breast cancer - A prospective study / D. Vasiljevic [et al.] // Häufigkeit einer Pneumonitis nach Bestrahlung bei Brustkrebs – Eine prospektive Studie. Strahlenther Onkol. -2018. – Vol. 194. – N 6. – P.520-532.
  9. Early response of lung in breast cancer irradiation: radiologic density changes measured by CT and symptomatic radiation pneumonitis / B. Wennberg [et al.] // Int. J. Radiat. Oncol. Biol. Phys. – 2002. – Vol. 52. – N 5. – P. 1196-1206.
  10. Using benchmarked lung radiation dose constraints to predict pneumonitis risk: Developing a nomogram for patients with mediastinal lymphoma / C.C. Pinnix [et al.] // Adv. Radiat. Oncol. – 2018. – Vol. 3. – N 3. – P. 372-381. 
  11. Даниленко А.А. Ранние и поздние легочные осложнения лучевой терапии лимфомы Ходжкина / А.А. Даниленко, С.В. Шахтарина // Пульмонология. – 2013. – Том. 6. – С.92-98.

Danilenko AA, Shakhtarina SV. Ranniye i pozdniye legochnyye oslozhneniya luchevoy terapii limfomy Khodzhkina [Early and late pulmonary complications of radiation therapy for Hodgkin lymphoma]. Pul'monologiya. [Pulmonology] 2013;(6):92-98.

  1. Radiation-Induced Lung Injury: Assessment and Management / A.N. Hanania [et al.] // Chest. – 2019. – Vol. 156. – N 1. – P. 150-162.
  2. Bledsoe T.J. Radiation Pneumonitis / T.J. Bledsoe, S.K. Nath, R.H. Decker // Clin. Chest. Med. – 2017. – Vol. 38. – N 2. – P. 201-208.
  3. New era of radiotherapy: An update in radiation-induced lung disease / M.F.K. Benveniste [et al.] // Clin. Rad. – 2013. – Vol. 68. – N 6. – P.e275 - e290.
  4. Бардычев М.С., Цыб А.Ф. // Местные лучевые повреждения// М. - 1985. - с. 78.

Bardychev MS, Tsyb AF. Mestnyye luchevyye povrezhdeniya [Local radiation injuries]. 1985. P. 78

  1. https://ctep.cancer.gov/protocolDevelopment/electronic_applications/docs/ CTCAE_v5_Quick_Reference_8.5x11.pdf– электронный ресурс. Дата обращения 10 мая 2020.
  2. Jain V., Berman A.T. Radiation Pneumonitis: Old Problem, New Tricks / V. Jain, A.T. Berman // Cancers (Basel). – 2018. – Vol. 10. – N 7. – P. 222.
  3. RTOG Late Effects Working Group. Overview. Late Effects of Normal Tissues (LENT) scoring system / P. Rubin [et al.] // Int. J. Radiat. Oncol. Biol. Phys. – 1995. – Vol. 31. – P. 1041-1042.
  4. LENT SOMA Tables // Radiother. Oncol. – 1995. – Vol. 35. – P. 17-60.
  5. Abid S.H., Malhotra V., Perry M.C. Radiation-induced and chemotherapy-induced pulmonary injury / S.H. Abid, V. Malhotra, M.C. Perry // Curr. Opin. Oncol. – 2001. – Vol. – 13. – N 4. – P. 242-248.
  6. Changes of cough reflex sensitivity induced by cancer radiotherapy of chest and neck regions / N. Javorkova [et al.] // J. Physiol. Pharmacol. – 2006. – Vol. 57. – Suppl. 4. – P.157-163.

Nudnov NV [et al.] Vozmozhnosti kachestvennoy otsenki luchevykh povrezhdeniy legkikh metodom komp'yuternoy tomografii [Qualitative assessment of radiation injuries of the lungs by computed tomography] Meditsinskaya vizualizatsiya [Medical imaging] 2016;1:39-46.

  1. Возможности качественной оценки лучевых повреждений легких методом компьютерной томографии / Н.В.Нуднов и др. // Медицинская визуализация. – 2016. – № 1. – С. 39-46
  2. Ghaye B., Wanet M., El Hajjam M. Imaging after radiation therapy of thoracic tumors / B. Ghaye, M. Wanet, M. El Hajjam // Diagn. Interv. Imaging. – 2016. – Vol. 97. – N10. – P. 1037-1052.
  3. Результаты количественной оценки постлучевых изменений в легких у онкологических пациентов, полученные с помощью новой методики анализа динамически выполненных РКТ – исследований органов грудной клетки / В.В. Леденев и др. // Вестник рентгенологии и радиологии. – 2020. – Том 101. – № 1. – С. 30-38.

LedenevVV, NudnovNV, SotnikovVM, BaryshnikovaDV. Rezul'taty kolichestvennoy otsenki postluchevykh izmeneniy v legkikh u onkologicheskikh patsiyentov, poluchennyye s pomoshch'yu novoy metodiki analiza dinamicheski vypolnennykh RKT – issledovaniy organov grudnoy kletki [The results of quantitative evaluation of postradiation changes in lung cancer patients, which were obtained using a new procedure for analysis of dynamic X-ray computed tomography imaging of thoracic organs] Vestnik rentgenologii i radiologii [Journal of radiology and nuclear medicine]. 2020;101(1):30-38.

  1. Abnormal pulmonary function tests predict the development of radiation-induced pneumonitis in advanced non-small cell lung Cancer / L. Torre-Bouscoulet [et al.] // Respir. Res. – 2018. – Vol. 19. – N 1. – P.72-82.
  2. Long-term changes in pulmonary function tests after definitive radiotherapy for lung cancer / K.L. Miller [et al.] // Int. J. Radiat. Oncol. Biol. Phys. – 2003. – Vol. 56. – N 3. – P.611-615.
  3. Time and dose-related changes in lung perfusion after definitive radiotherapy for NSCLC / K.P. Farr [et al.] // Radiother. Oncol. – 2018. – Vol. – 126. – N 2. – P. 307-311.
  4. Bilateral lymphocytic alveolitis: a common reaction after unilateral thoracic irradiation / C. Martín [et al.] // Eur. Respir. J. – 1999. – Vol. 13. – N 4. – P. 727-732.
  5. Radiation-Induced Lung Injury: Assessment and Management / A.N. Hanania [et al.] // Chest. – 2019. – Vol. 156. – N 1. – P. 150-162.
  6. Combing NLR, V20 and mean lung dose to predict radiation induced lung injury in patients with lung cancer treated with intensity modulated radiation therapy and chemotherapy / W.Y. Pan [et al.] // Oncotarget. – 2017. – Vol. 8. – N 46. – P. 81387-81393.
  7. Kong F.M., Ao X, Wang L., Lawrence T.S. The use of blood biomarkers to predict radiation lung toxicity: a potential strategy to individualize thoracic radiation therapy / F.M. Kong, X Ao, L. Wang, T.S. Lawrence // Cancer Control. – 2008. – Vol. 15. – N 2. – P.140-150.
  8. West J.B. The beginnings of cardiac catheterization and the resulting impact on pulmonary medicine / J.B. West // Am. J. Physiol. Lung Cell Mol. Physiol. – 2017. – Vol. 313. – N 4. – P. L651-L658.
  9. Serum toll-like receptors are potential biomarkers of radiation pneumonia in locally advanced NSCLC / F. Lan [et al.] // Int. J. Clin. Exp. Pathol. – 2014. – Vol. 7. – N11. – P. 8087-8095.
  10. Современные принципы обеспечения радиационной безопасности при использовании источников ионизирующего излучения в медицине. Часть 2. Радиационные риски и совершенствование системы радиационной защиты / Г.Г. Онищенко, А.Ю. Попова, И.К. Романович [и др.] // Радиационная гигиена. – 2019. – Том. 12. – № 2. – С. 6-24.

Onischenko GG, Popova AY, Romanovich IK [et al.] Modern principles of the radiation protection from sources of ionizing radiation in medicine Part 2: radiation risks and development of the system of radiation protection [Sovremennyye printsipy obespecheniya radiatsionnoy bezopasnosti pri ispol'zovanii istochnikov ioniziruyushchego izlucheniya v meditsine. Chast' 2. Radiatsionnyye riski i sovershenstvovaniye sistemy radiatsionnoy zashchity] Radiatsionnaya Gygiena [Radiation Hygiene]. 2019;12(2):6-24.

  1. Fried D.V., Das S.K., Marks L.B. Imaging Radiation-Induced Normal Tissue Injury to Quantify Regional Dose Response / D.V. Fried, S.K. Das, L.B. Marks // Semin. Radiat. Oncol. – 2017. – Vol. 27. – N 4. – P. 325-331.
  2. Analysis of Clinical and Dosimetric Factors Influencing Radiation-Induced Lung Injury in Patients with Lung Cancer / S. Han, F. Gu, G. Lin G [et al.] // J. Cancer. – 2015. – Vol. 6. – N 11. – P. 1172-1178.
  3. Radiobiological evaluation of simultaneously dose-escalated versus non-escalated intensity-modulated radiation therapy for patients with upper thoracic esophageal cancer / B.T. Huang, L.L. Wu, L.J. Guo, [et al.] // Onco. Targets Ther. – 2017. – Vol. 10. – P. 2209-2217.
  4. Clinical and Functional Assays of Radiosensitivity and Radiation-Induced Second Cancer / M. Habash, L.C. Bohorquez, E. Kyriakou [et al.] // Cancers (Basel). – 2017. – Vol. 9. – N 11. – P.147.
  5. Vogelius I.R., Bentzen S.M. A literature-based meta-analysis of clinical risk factors for development of radiation induced pneumonitis. / I.R. Vogelius, S.M. Bentzen //Acta Oncol. – 2012. – Vol. 51. – N 8. – P. 975-983.
  6. Inoue T., Shiomi H., Oh R.J. Stereotactic body radiotherapy for Stage I lung cancer with chronic obstructive pulmonary disease: special reference to survival and radiation-induced pneumonitis / T. Inoue, H. Shiomi, R.J. Oh // J. Radiat. Res. – 2015. – Vol. 56. – N 4. – P. 727-734.
  7. Diabetes mellitus and radiation induced lung injury after thoracic stereotactic body radiotherapy / N.S. Kalman, G.D. Hugo, R.N. Mahon [et al.] // Radiother. Oncol. – 2018. – Vol. 129. – N 2. – P. 270-276.
  8. Pneumocystis carinii infection sensitizes lung to radiation-induced injury after syngeneic marrow transplantation: role of CD4+ T cells / L. Bruckner, F. Gigliotti, T. Wright, [et al.] // Am. J. Physiol. Lung Cell Mol. Physiol. – 2006. – Vol. 290. – N 6. – P. L1087-L1096.
  9. Lung irradiation increases mortality after influenza A virus challenge occurring late after exposure / C.M. Manning, C.J. Johnston, C.K. Reed [et al.] // Int. J. Radiat. Oncol. Biol. Phys. – 2013. – Vol. 86. – N 1. – P. 128-135.
  10. Большая медицинская энциклопедия / гл. ред. Б. В. Петровский. — 3-е изд. — М.: Советская энциклопедия, 1974—1989. — Т. 21. – С. 479.

Bol'shaya meditsinskaya entsiklopediya [Big Medical Encyclopedia] / BV Petrovskiy. 3rdedition. Moscow, Sovetskaya entsiklopediya [Soviet Encyclopedia], 1974-1989. Vol. 21; 479.

  1. Сычева М.Г., Грушина Т.И. Медикаментозные средства предотвращения и минимизации лучевых повреждений легких / М.Г. Сычева, Т.И. Грушина // Пульмонология. – 2013. – № 6. – C. 85-91.

Sycheva MG, Grushina TI. Medikamentoznyye sredstva predotvrashcheniya i minimizatsii luchevykh povrezhdeniy legkikh [Drug therapy to prevent and diminish radiation injury of the lungs] Pul'monologiya [Pulmonologiya]. 2013;(6):85-91.

  1. Johnke R.M., Sattler J.A., Allison R.R. Radioprotective agents for radiation therapy: future trends. / R.M. Johnke, J.A. Sattler, R.R. Allison // Future Oncol. – 2014. – Vol. 10. – N 15. – P.2345-2357.
  2. Pharmacology of natural radioprotectors [published correction appears in Arch Pharm Res. 2019 Jun 17;:] [published correction appears in Arch Pharm Res. 2020 Feb;43(2):272-274] / G.I. Mun, S. Kim, E. Choi [et al.] // Arch. Pharm. Res. – 2018. – Vol. 41. – N 11. – P. 1033-1050.
  3. Moulder J.E. Pharmacological intervention to prevent or ameliorate chronic radiation injuries / J.E. Moulder // Semin. Radiat. Oncol. – 2003. – Vol. 13. – N 1. – P. 73-84. 
  4. Celecoxib enhances the radiosensitivity of HCT116 cells in a COX-2 independent manner by up-regulating BCCIP / X.T. Xu, W.T. Hu, J.Y. Zhou [et al.] // Am. J. Transl. Res. – 2017. – Vol. 9. – N 3. – P. 1088-1100. 
  5. Kwok E., Chan C.K. Corticosteroids and azathioprine do not prevent radiation-induced lung injury / E. Kwok, C.K. Chan // Can. Respir. J. – 1998. – Vol. 5. – N 3. – P. 211-214. 
  6. Steroid treatment increases the recurrence of radiation-induced organizing pneumonia after breast-conserving therapy / K. Otani, K. Nishiyama, Y. Ito [et al.] // Cancer Med. – 2014. – Vol. 3. – N 4. – P. 947-953. 
  7. Effects of dexamethasone on late radiation injury following partial-body and local organ exposures / J.P. Geraci, M.S. Mariano, K.L. Jackson [et al.] // Radiat. Res. – 1992. – Vol. 129. – N1. – P. 61-70.
  8. Постлучевой пневмонит в практике пульмонолога / Н.Л. Семищева, Е.И. Карапетян, Т.А. Мальцева [и др.] // Бюллетень физиологии и патологии дыхания. – 2014. – № 53. – С. 137-142.

NL Semishcheva, YI Karapetyan, TA Mal'tseva et al. Postluchevoy pnevmonit v praktike pul'monologa [Post-radiation pneumonitis in the practice of a pulmonologist] Byulleten' fiziologii i patologii dykhaniya [Bulletin of physiology and respiration pathology] 2014;53:137-142.

  1. Inhalative steroids as an individual treatment in symptomatic lung cancer patients with radiation pneumonitis grade II after radiotherapy - a single-centre experience / C. Henkenberens, S. Janssen, M. Lavae-Mokhtari [et al.] // Radiat. Oncol. – 2016. – Vol. 11. – P. 12.
  2. Melatonin Alleviates Radiation-Induced Lung Injury via Regulation of miR-30e/NLRP3 Axis / X. Wu, H. Ji, Y. Wang [et al.] // Oxid. Med. Cell Longev. – 2019. – Art. 4087298.
  3. Radiation pulmonary toxicity: from mechanisms to management / P.R. Graves, F. Siddiqui, M.S. Anscher [et al.] // Semin. Radiat. Oncol. – 2010. – Vol. 20. – N 3. – P. 201-207.
  4. Zhao W., Robbins M.E. Inflammation and chronic oxidative stress in radiation-induced late normal tissue injury: therapeutic implications / W. Zhao, M.E. Robbins // Curr. Med. Chem. – 2009. – Vol. 16. – N 2. – P.130-143. 
  5. Simvastatin attenuates radiation-induced murine lung injury and dysregulated lung gene expression [published correction appears in Am J Respir Cell Mol Biol. 2013 Oct;49(4):688]. / B. Mathew, Y. Huang, J.R. Jacobson [et al.] // Am. J. Respir. Cell Mol. Biol. – 2011. – Vol. 44. – N 3. – P. 415-422.
  6. The relation of radiation-induced pulmonary fibrosis with stress and the efficiency of antioxidant treatment: an experimental study / V. Kaya, R. Yazkan, M. Yıldırım [et al.] // Med. Sci. Monit. – 2014. – Vol. 20. – P. 290-296.
  7. Post-irradiation dietary vitamin E does not affect the development of radiation-induced lung damage in rats / E.M. Wiegman, M.M. van Gameren, H.H. Kampinga [et al.] // Radiother. Oncol. – 2004. – Vol. 72. – N 1. – P. 67-70.
  8. Pentoxifylline in prevention of radiation-induced lung toxicity in patients with breast and lung cancer: a double-blind randomized trial / B. Ozturk, I. Egehan, S. Atavci [et al.] // Int. J. Radiat. Oncol. Biol. Phys. – 2004. – Vol. 58. – N 1. – P. 213-219.
  9. Daily Lisinopril vs Placebo for Prevention of Chemoradiation-Induced Pulmonary Distress in Patients With Lung Cancer (Alliance MC1221): A Pilot Double-Blind Randomized Trial / T.T. Sio, P.J. Atherton, L.D. Pederson [et al.] // Int. J. Radiat. Oncol. Biol. Phys. – 2019. – Vol. 103. – N 3. – P. 686-696. 
  10. Targeting the Renin-angiotensin system combined with an antioxidant is highly effective in mitigating radiation-induced lung damage / J. Mahmood, S. Jelveh, A. Zaidi [et al.] // Int. J. Radiat. Oncol. Biol. Phys. – 2014. – Vol. 89. – N 4. – P. 722-728.
  11. High-throughput screening identifies two classes of antibiotics as radioprotectors: tetracyclines and fluoroquinolones / K. Kim, J.M. Pollard, A.J. Norris [et al.] // Clin. Cancer Res. – 2009. – Vol. 15. – N 23. – P. 7238-7245.
  12. Clarithromycin Attenuates Radiation-Induced Lung Injury in Mice / S.J. Lee, C.O. Yi, R.W. Heo [et al.] // PLoS One. – 2015. – Vol. 10. – N 6. – P. e0131671.
  13. Azithromycin attenuates acute radiation-induced lung injury in mice / F. Tang, R. Li, J. Xue [et al.] // Oncol. Lett. – 2017. – Vol. 14. – N 5. – P. 5211-5220.
  14. Trichostatin A inhibits radiation-induced epithelial-to-mesenchymal transition in the alveolar epithelial cells / D. Nagarajan, L. Wang, W. Zhao [et al.] // Oncotarget. – 2017. – Vol. 8. – N 60. – P. 101745-101759.
  15. Epidermal growth factor receptor-tyrosine kinase inhibitor (gefitinib) augments pneumonitis, but attenuates lung fibrosis in response to radiation injury in rats / K. Miyake, K. Tani, S. Kakiuchi [et al.] // J. Med. Invest. – 2012. – Vol. 59. – N 1-2. – P. 174-185.
  16. Keratinocyte growth factor (KGF) gene therapy mediated by an attenuated form of Salmonella typhimurium ameliorates radiation induced pulmonary injury in rats / C.J. Liu, X.Q. Ha, J.J. Jiang [et al.] // J. Radiat. Res. – 2011. – Vol. 52. – N 2. – P. 176-184.
  17. Prevention of radiation-induced pneumonitis by recombinant adenovirus-mediated transferring of soluble TGF-beta type II receptor gene / Z. Haiping, K. Takayama, J. Uchino [et al.] // Cancer Gene Ther. – 2006. – Vol. 13. – N 9. – P. 864-872.
  18. Protective effect of ulinastatin in patients with non-small cell lung cancer after radiation therapy: a randomized, placebo-controlled study / P. Bao, W. Zhao, Y. Li [et al.] // Med. Oncol. – 2015. – Vol. 32. – N 1. – P.405.
  19. Inhibition of the tumor necrosis factor-alpha pathway is radioprotective for the lung / M. Zhang, J. Qian, X. Xing [et al.] // Clin. Cancer Res. – 2008. – Vol. 14. – N 6. – P. 1868-1876.
  20. Pneumonitis resulting from radiation and immune checkpoint blockade illustrates characteristic clinical, radiologic and circulating biomarker features / J.D. Schoenfeld, M. Nishino, M. Severgnini [et al.] // J. Immunother. Cancer. – 2019. – Vol. 7. – N 1. – P. 112.
  21. Imatinib therapy reduces radiation-induced pulmonary mast cell influx and delays lung disease in the mouse / D.M. Thomas, J. Fox, C.K. Haston [et al.] // Int. J. Radiat. Biol. – 2010. – Vol. 86. – N 6. – P.436-444. 
  22. The protective effects of ambroxol on radiation lung injury and influence on production of transforming growth factor beta1 and tumor necrosis factor alpha / D.H. Xia, L. Xi, C. Xv [et al.] // Med. Oncol. – 2010. – Vol. 27. – N 3. – P. 697-701.
  23. Radiation-induced pulmonary gene expression changes are attenuated by the CTGF antibody Pamrevlumab / M.D. Sternlicht, U. Wirkner, S. Bickelhaupt [et al.] // Respir. Res. – 2018. – Vol. 19. – N 1. – P. 14.
  24. Xu S., Liu C., Ji H.L. Concise Review: Therapeutic Potential of the Mesenchymal Stem Cell Derived Secretome and Extracellular Vesicles for Radiation-Induced Lung Injury: Progress and Hypotheses / S. Xu, C. Liu, H.L. Ji // Stem Cells Transl. Med. – 2019. – Vol. 8. – N 4. – P. 344-354.

 

UDC 614.2:004(470+571)(048.8)

DOI: 10.20969/VSKM.2020.13(3).74-80

PDF download KEY ELEMENTS OF ELECTRONIC HEALTH INFORMATION SYSTEM IN THE RUSSIAN FEDERATION (review and analysis of research articles)

SHUBIN IGOR V., ORCID: 0000-0003-2393-4685; C. Med. Sci., Honored Doctor of the Russian Federation, deputy director
of the Center for the Introduction of Changes of the Ministry of Health of the Moscow region, Russia, 143408, Moscow region, Krasnogorsk, Karbyshev str., 4, tel. 8-905-500-35-30, e-mail: shubin-igor@mail.ru

MISHLANOV VITALY YU., ORCID: 0000-0002-8428-6020; D. Med. Sci., professor, corresponding Member of the Russian Academy of Sciences, secretary of the Electronic and Mobile Medicine Group of the European Respiratory Society, the Head of the Department of introduction internal medicine No 1 of Perm State Medical University named after academician E.A. Wagner, Russia, 614990, Perm, Petropavlovskaya str., 26, tel. 8-950-467-76-96, e-mail: permmed@hotmail.com

Abstract. Aim. The aim of the study was to review certain new strategies for the development of electronic health information systems. Material and methods. A review of research articles devoted to the application of modern technologies of primary medical care delivery in foreign countries and to the development of electronic medicine in the Russian Federation was conducted. The applied importance of e-medicine in the eld of remote observation and rehabilitation of patients with chronic diseases is being emphasized. Results and discussion. The main objectives of the rehabilitation programme for chronic patients are to prevent relapses, to improve physical performance and quality of life. Special attention is given to patients discharged from hospital after an exacerbation of the disease. Reduction of the economic costs of rehabilitation programmes is being achieved through the introduction of remote monitoring methods and through development of distance learning programmes for patients. Along with various technical solutions to control heart rate, blood pressure, partial oxygen pressure and other indicators, the most effective is the use of interactive questionnaires to assess the health status, to control parameters of the course of a particular disease and quality of life. In Russia, the most effective direction of electronic medical records development is the creation of applications designed as structured interactive questionnaires. Their main differences from foreign systems are a large amount of information, the possibility of preliminary early diagnosis and compilation of clinical registers of patients for the purpose of active observation. Electronic medicine may have special importance in connection with the epidemic of new corona virus infection COVID-19. A large number of patients who have suffered from COVID-related community acquired pneumonia may subsequently suffer from respiratory dysfunctions of varying severity. The growth of interstitial pulmonary lesions is possible. Delayed or refused rehabilitation of these patients threatens the growth of the number of citizens with developed persistent disability, reduced quality of life and life expectancy. The need for rehabilitation, dispensary dynamic monitoring and treatment of these patients is expected to grow. Conclusion. The presented analysis makes it possible to formulate current tasks, the solution of which may signi cantly affect the mortality of patients with chronic non-communicable diseases. Creation of clinical registers of patients and application of telemedical technologies are an urgent necessity.

Key words: electronic health information systems, telemedicine, rehabilitation, pulmonology.

For reference: Shubin IV, Mishlanov VYu. Key elements of electronic health information system in the Russian Federation (review and analysis of research articles). The Bulletin of Contemporary Clinical Medicine. 2020; 13 (3): 73-80. DOI: 10.20969/VSKM.2020.13(3).73-80.

References

1. Ukaz Prezidenta Rossijskoj Federacii ot 01/12/2016 goda No 642 «O Strategii nauchno-tekhnologicheskogo razvitiya Rossijskoj Federacii [Decree of the President of the Russian Federation dated 01/12/2016, No 642 “On the Strategy for Scienti c and Technological Development of the Russian Federation]. 2019; http://kremlin.ru/acts/ bank/41449/page/2.

2. Spruit MA, Singh SJ, Garvey Ch, et al. An Official American Thoracic Society/European Respiratory Society Statement: Key Concepts and Advances in Pulmonary Rehabilitation. Am J Respir Crit Care Med. 2013; 88 (8): e13–e64.

3. Peretti A, Amenta F, Tayebati SKh, Nittari G, Mahdi SS. Telerehabilitation: Review of the State-of-the-Art and Areas of application. JMIR Rehabil Assist Technol. 2017; 4 (2): e7. doi: 10.2196/rehab.7511.

4. Tomasic I, Tomasic N, Trobec R, Krpan M, Kelava T. Continuous remote monitoring of COPD patients— justi cationand explanation of the requirements and a surveyof the available technologies. Medical & Biological Engineering & Computing. 2018; 56: 547–569.

5. Damhus ChS, Emme Ch, Hansen H. Barriers and enablers of COPD telerehabilitation – a frontline staff perspective. International Journal of COPD. 2018; 13: 2473-2482.

6. COPD 2019 Report. Available on 19/03/2019. https:// goldcopd.org/: 62-65.

  1. Mishlanov V, Chuchalin A, Chereshnev V, Poberezhets V, Vitacca M, Nevzorova V, Aisanov Z, Vizel A, Shubin I, Nikitin A, Zulkarneev R, Khovaeva Y. Scope and new horizons for implementation of m-Health/e-Health services in pulmonology in 2019. Monaldi Archives for Chest Disease. 2019; 89: 1112.

  2. Sharp C, McCabe M, Hussain MJ, et al. Pulmonary rehabilitation in interstitial lung disease – a prospective, observational study. Thorax. 2015; 70 (3): A1–A254, S99.

  3. Atsou K, Crequit P, Chouaid Ch, Hejblum G. Simulation-Based Estimates of the Effectiveness and Cost-Effectiveness of Pulmonary Rehabilitation in Patients with Chronic Obstructive Pulmonary Disease in France. PLoS One. 2016; 11 (6): e0156514.

  4. Bairapareddy KCh, Chandrasekaran B, Agarwal U. Telerehabilitation for Chronic Obstructive Pulmonary Disease patients – an underrecognized management in tertiary care. J Palliat Care. 2018; 24: 529-533.

  5. Kaltsakas G, Papaioannou AL, Vasilopoulou M, et al. Effectiveness of home maintenance telerehabilitation on COPD exacerbations. Thorax. 2015; 70 (3): A1–A254, S98.

  6. Rodriguez A. Telerehabilitation Must Involve Staff, Study Finds AJMC® in the Press, March 15, 2019. Available on 19/03/2019. https://www.ajmc.com/newsroom/ implementing-effective-copd-telerehabilitation-must-involve-staff-study-nds.

  7. Paneroni M, Colombo F, Papalia A, Colitta A, Borghi G, Saleri M, Cabiaglia A, Azzalini E, Vitacca M. Is Telerehabilitation a Safe and Viable Option for Patients with COPD? A Feasibility Study. COPD. 2015; 12 (2): 217-225.

  8. Tsai LL, McNamara R, Moddel Ch, McKenzie D, Alison J, McKeough Z. Telerehabilitation in people with chronic obstructive pulmonary disease (COPD): A randomised controlled trial. European Respiratory Journal. 2016; 48: PA2065.

  9. Belyshev DV, Guliev YaI, Miheev AE. Izmenenie funkcional’nyh trebovanij k MIS v processe perestrojki sistem zdravoohraneniya [Changing the functional requirements for IIAs in the process of restructuring health systems]. Vrach i informacionnye tekhnologii [Doctor and Information Technology]. 2017; 4: 6-25.

  10. Chuchalin AG, Chereshnev VA, Mishlanov VYu, Mishlanov YaV, Nikitin AE, SHubin IV. Bioetika, iskusstvennyj intellekt i medicinskaya diagnostika [Bioethics, Arti cial Intelligence and Medical Diagnostics]. Perm’ [Perm]. 2019; 205 p.

  11. Chuchalin AG, Chereshnev VA, Mishlanov VJu, Mishlanov YaV, Nikitin AE, Shubin IV. Bioethics, arti cial intelligence and medical diagnosis. Perm: PSMU. 2019; 184 p.

  12. e-Health in Canada – Electronic Health Record – Canadian Government eHealth. Availableon 19/03/2019. https://www.itworldcanada.com/article/e-health-in-canada-electronic-health-record-canadian-government-ehealth/1286.

  13. Vinogradov AN, Guliev YaI, Kurshev EP, Malyh VL. Perspektivnye napravleniya issledovanij v oblasti klinicheskogo modelirovaniya, upravleniya i prinyatiya reshenij [Promising areas of research in the eld of clinical modeling, management and decision making]. Vrach i informacionnye tekhnologii [Doctor and Information Technology]. 2014; 5: 47-59.

  14. Mishlanov YaV, Mishlanov VYu, Mishlanova IV, Mishlanova SL. Svidetel’stvo o gosudarstvennoj registracii programmy dlya EVM «Elektronnaya poliklinika» No2012614202 [Certi cate of state registration of the computer program «Electronic Clinic» No 2012614202]. 12/05/12.

  15. Mishlanov VYu, Shubin IV, Bekker KN, Katkova AV, Koshurnikova EP. Analiz elektronnogo klinicheskogo registra bol’nyh hronicheskoj obstruktivnoj bolezn’yu legkih: effektivnost’ dinamicheskogo nablyudeniya i razlichnyh programm lecheniya [Analysis of the electronic clinical register of patients with chronic obstructive pulmonarydisease: the effectiveness of dynamic monitoring and various treatment programs]. Terapevticheskij arhiv [Therapeutic Archive]. 2019; 91 (1): 78-83.

22. Mishlanov VYu, Chuchalin AG, Chereshnev VA, Shubin IV, Nikitin AE. Novye tekhnologii v reabilitacii bol’nyh respiratornymi zabolevaniyami; Telemonitoring i telereabilitaciya [New technologies in the rehabilitation of patients with respiratory diseases; Telemonitoring and telerehabilitation]. Prakticheskaya pul’monologiya [Practical pulmonology]. 2019; 3: 28-31.

23. Katkova AV, Shubin IV, Mishlanov VYu, Koryagina NA, Syromyatnikova LI, Nikitin AE. Interaktivnyj opros s pomoshch’yu avtomatizirovannoj sistemy «Elektronnaya poliklinika» pri konsul’tirovanii v udalennom dostupe [Interactive survey using the automated system «Electronic Clinic» when consulting in remote access]. Sovremennaya nauka: aktual’nye problemy teorii i praktiki; Seriya: Estestvennye i tekhnicheskie nauki [Modern Science: Actual Problems of Theory and Practice; Series: Natural and Technical Sciences]. 2019; 9: 125-131.

24. Mishlanov VYu, Chuchalin AG, Chereshnev VA, Shubin IV, Nikitin AE. Novye tekhnologii v medicine; Telemonitoring i telereabilitaciya [New technologies in medicine; Telemonitoring and telerehabilitation]. Sovremennyj mir, aktual’nye voprosy bioetiki, molekulyarnoj i personalizirovannoj mediciny: sbornik materialov mezhdunarodnogo evro-aziatskogo kongressa po voprosam bioetiki, molekulyarnoj i personalizirovannoj mediciny «Biomed-inn-2019» [The modern world, current issues of bioethics, molecular and personalized medicine: a collection of materials of the International Euro-Asian Congress on bioethics, molecular and personalized medicine «Biomed-inn-2019»]. Perm’: Permskiy natsional’nyy issledovatel’skiy politekhnicheskiy universitet [Perm: Perm National Research Polytechnic University]. 2019; 117-125.

25. Shubin IV, Belevskij AS, Chuchalin AG, Avdeev SN, Mishlanov VYu, Zajcev AA, Romanov VV, Stepanyan IE, Leckaya OA, Kosheleva OV, Suin PA, Tatevosov VR. Klinicheskie rekomendacii «Mediko-social’naya i voenno-vrachebnaya ekspertiza v pul’monologii i ftiziatrii» [Clinical recommendations «Medical-social and military-medical examination in pulmonology and phthisiology»]. Moskva: RRO [Moscow: RRO]. 2018; 45 p.

26. Mishlanov VYu, Bekker KN. Medikamentoznaya terapiya hronicheskoj obstruktivnoj bolezni legkih v real’noj klinicheskoj praktike [Drug therapy of chronic obstructive pulmonary disease in real clinical practice]. Prakticheskaya pul’monologiya [Practical pulmonology]. 2018; 4: 10-13.

27. Bekker KN, Mishlanov VYu, Katkova AV, Koshurnikova EP, Syromyatnikova LI. Rasprostranennost’ serdechno-sosudistoj patologii u bol’nyh s razlichnymi fenotipami hronicheskoj obstruktivnoj bolezni legkih [The prevalenceof cardiovascular disease in patients with variousphenotypes of chronic obstructive pulmonary disease]. Vestnik sovremennoj klinicheskoj mediciny [Bulletin of modern clinical medicine]. 2019; 12 (1): 24-30.

28. Mishlanov VYu. Kliniko-gomeostaticheskie i terapevticheskie aspekty u bol’nyh vospalitel’nymi zabolevaniyami sistemy dyhaniya [Clinical homeostatic and therapeutic aspects in patients with in ammatory diseases of the respiratory system]. Perm’. 2002; 44 p.

29. Tuev AV, Mishlanov VYu. Hronicheskie bronhoobstruktivnye zabolevaniya i serdechno-sosudistaya sistema [Chronic bronchial obstructive diseases and the cardiovascular system]. Perm’ [Perm]. 2008; 184 p. http://disus. ru/dissertatsii/421259-1-av-tuev-mishlanov-hronicheskie-bronhoobstruktivnie-zabolevaniya-serdechno-sosudista-ya-sistema-perm-2008-udk-61624-02-616233.php

 

PRACTICAL EXPERIENCE

UDC 617.55-089.197.4-06

DOI: 10.20969/VSKM.2020.13(3).81-85

PDF download CAUSES OF UNFAVORABLE OUTCOMES IN EMERGENCY SURGERY

KRASILNIKOV DMITRIY M., D. Med. Sci., professor, the Head of the Department of surgical diseases of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, e-mail: dmkras131@gmail.com

MIRGASIMOVA DZHAUKHARIYA M., C. Med. Sci., associate professor of the Department of surgical diseases of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, e-mail: d.mirgasimova@yandex.ru

ABDULYANOV AIDAR V., C. Med. Sci., associate professor of the Department of surgical diseases of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, e-mail: aabdulianov@mail.ru

ZEFIROV RUSLAN A., C. Med. Sci., the Head of the Department of surgery No 1 of Republican Clinical Hospital, Russia, 420064, Kazan, Orenburgskiy highway, 138, e-mail: abdominalsurgery@mail.ru

ZAKHAROVA ANNA V., C. Med. Sci., assistant of professor of the Department of surgical diseases of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, e-mail: zahanna83@yandex.ru

SEMENOVA IRINA I., graduate student of the Department of surgical diseases of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, e-mail: irena.1981@mail.ru

Abstract. Aim. The aim of the study was to determine the causes contributing to unfavorable treatment outcomes and to de ne preventive measures based on a retrospective study of direct outcomes of surgeries in patients with common abdominal organ diseases. Material and methods. The outcomes of surgical interventions performed in the clinic of surgical diseases of Kazan State Medical University of the Ministry of Health of Russia at the departments of abdominal surgery and coloproctology at Republic clinical hospital of the Ministry of health of the Republic of Tatarstan for the period from 2013 to 2019 on 5 539 patients with acute appendicitis, acute cholecystitis, pinched hernia, and acute intestinal obstruction were analyzed. Results and discussion. Early post-surgical complications in patients with acute appendicitis occurred in 17,1% of cases with 0,08% mortality, in 18,0% of cases with acute cholecystitis with 1,7% mortality, in 23.8% of patients with a pinched hernia with 3,2% mortality, and in 29,2% of cases of acute intestinal obstruction with 12,6% mortality. The reasons contributing to the development of early post-surgical complications were identi ed and the measures to prevent them were de ned. Conclusion. Timely appeal for medical care by the patients and full-scale diagnostics performed at the admission department are of crucial importance for the outcome of the surgical intervention in emergency surgery.

Key words: early postoperative abdominal complications, causes of complications, prevention of complications.

For reference: Krasilnikov DM, Mirgasimova DM, Abdulianov AV, Ze rov RA, Zakharova AV, Semenova II. Causes of unfavorable outcomes in emergency surgery. The Bulletin of Contemporary Clinical Medicine. 2020; 13 (3): 81-85. DOI: 10.20969/VSKM.2020.13(3).81-85.

References

1. Savelyev VS. Rukovodstvo po neotlozhnoy khirurgii organov bryushnoy polosti: Rukovodstvo dlya vrachey [Guidelines for emergency abdominal surgery: A guide for doctors]. Moskva: MIA [Moscow: MIA]. 2014; 544 p.

2. Zatevakhin II, Kiriyenko AI, Sazhina AV. Neotlozhnaya abdominal’naya khirurgiya: Metodicheskoye rukovodstvo dlya praktikuyushchego vracha [Emergency Abdominal Surgery: A Guide for a Practitioner]. Moskva: MIA [Moscow: MIA]. 2018; 488 p.

3. Abdullaev EG, Babyshin VV. Aktual’nyye voprosy relaparotomii: monogra ya [Actual issues of relaparotomy: monograph]. Vladimir: Izd-vo VlGU [Vladimir: VlSU Publishing House]. 2016; 192 p.

4. Krasilnikov DM, Mirgasimova DM, Malova II. Analiz prichin oshibok v neotlozhnoy abdominal’noy khirurgii [Analysis of the causes of errors in emergency abdominal surgery]. Materialy V Vserossiyskoy nauchno-prakticheskoy konferentsii po organizatsionnym I klinicheskim razdelam neotlozhnoy pomoshchi, 23 noyabrya 2018goda, Kazan’ [Materials of the V All-Russian Scienti c and Practicalconferences on organizational and clinical sections ofemergency care; November 23, Kazan]. 2018; 220-221.

5. Tomnyuk ND, Zdzitovetsky DE, Danilina EP. Naiboleye chastyye oslozhneniya v abdominal’noy khirurgii [The most frequent complications in abdominal surgery]. Sibirskoye meditsinskoye obozreniye [Siberian Medical Review]. 2013; 2: 100-102.

6. Tezyaev VV, Khavina EM, Besov AV. Prichiny relaparotomiy [Reasons for relaparotomy]. MediAl. 2017; 2 (20): 36-39.

7. Kyzhyrov AN, Almabaev YA, Zhantalinova NA. Ranniye posleoperatsionnyye vnutribryushnyye oslozhneniya – diagnostika i khirurgicheskoye lecheniye [Early postoperative intra-abdominal complications – diagnosis and surgical treatment]. Vestnik Kazakhskogo Natsional’nogo meditsinskogo universiteta [Bulletin of the Kazakh National Medical University]. 2016; 1: 401-405.

8. Hadzhibaev AM, Asomov KhKh, Riskiev UR. Diagnostika I khirurgicheskoye lecheniye rannikh posleoperatsionnykh vnutribryushnykh oslozhneniy [Diagnosis and surgical treatment of early postoperative intra-abdominal complications]. Vestnik ekstrennoy meditsiny [Bulletin of emergency medicine]. 2012; 1: 5-10.

9. Gostishchev VK, Dibirov MD, Khachatryan NN. Novyye vozmozhnosti pro laktiki posleoperatsionnykh oslozhneniy v abdominal’noy khirurgii [New opportunities for theprevention of postoperative complications in abdominalsurgery]. Khirurgiya; Zhurnal imeni NI Pirogova [Surgery; Journal named after NI Pirogov]. 2011; 5: 56-60.

 

EXPERIMENTAL STUDIES – TO CLINICAL MEDICINE

UDC [616-089-616-089.5]-06:616.89-008.45/47

DOI 10.20969/VSKM.2020.13(3).86-92

PDF download THE INFLUENCE OF MAJOR SURGERY ON RAT COGNITIVE FUNCTIONS

SHARIPOVA VISOLATKHON KH., D. Med. Sci., the Head of the Department of anesthesiology and intensive care of Republican Emergency Medicine Research Centre, Uzbekistan, 100107, Tashkent, Farhad str., 2, e-mail: visolat_78@mail.ru

VALIKHANOV ABROR A., junior researcher of the Department of anesthesiology and intensive care of Republican Emergency Medicine Research Centre, Uzbekistan, 100107, Tashkent, Farhad str., 2, e-mail: abror_27@mail.ru

ALIMOV AZAMAT KH., doctoral student of the Department of anesthesiology and intensive care of Republican Emergency Medicine Research Centre, Uzbekistan, 100107, Tashkent, Farhad str., 2, e-mail: azamat.kh.alimov@gmail.com

ABDULLAEV JAVLON G., attending anesthesiologist of the Department of anesthesiology and intensive care of Republican Emergency Medicine Research Centre, Uzbekistan, 100107, Tashkent, Farhad str., 2, e-mail: javlon.anestezist@gmail.com

Abstract. Aim. The aim of the study was to determine the effect of inhalation anesthesia and surgery on cognitive function in rats. Material and methods. The study was performed on laboratory male rats (n=80). The animals were divided into 4 groups: control group, anesthesia group without surgery (iso urane and fentanyl), minor surgery group, and major surgery group. Different types of memory (working, short-term, long-term) were studied using T-labyrinth and «Open Field» tests from day 7 to day 23 after the surgery and/or anesthesia. Results and discussion. Memory indices of different duration in animals who received two-hour anesthesia with iso urane and fentanyl without surgery did not differ from the results of the control group. There was a pressure of working, short-term as well as long-term memory in both groups (minor surgery, and major surgery) of the animals that underwent the surgery. In the group of minor surgery such pressure was reversible, whereas in the group of major surgery there was a more persistent deterioration of working and short-term memory. Conclusion. Anesthesia with iso urane and fentanyl for 2 hours without surgery does not cause memory pressure in laboratory rats. Surgeries with greater injury volume are associated with more persistent memory disturbances.

Key words: postsurgical cognitive dysfunction, neuropsychological testing, memory impairment, general anesthesia, iso urane, major surgery.

For reference: Sharipova VKh, Valikhanov AA, Alimov AKh, Abdullaev JG. The in uence of major surgery on rat cognitive functions. The Bulletin of Contemporary Clinical Medicine. 2020; 13 (3):86-92. DOI: 10.20969/VSKM.2020.13(3).86-92.

References

  1. Vutskits L, Xie Z. Lasting impact of general anaesthesia on the brain: mechanisms and relevance. Nat Rev Neurosci. 2016; 17: 705–717.

  2. Monk TG, Weldon BC, Garvan CW, et al. Predictors of cognitive dysfunction after major noncardiac surgery. Anesthesiology. 2008; 108: 18–30.

  3. Brambrink AM, Evers AS, Avidan MS, et al. Iso uraneinduced Neuroapoptosis in the Neonatal Rhesus Macaque Brain. Anesthesiology. 2010; 112 (4): 834-841.

  4. Steinmetz J, Christensen KB, Lund T, Lohse N, Rasmussen LS. ISPOCD Group. Long-term consequences of postoperative cognitive dysfunction. Anesthesiology. 2009; 110 (3): 548-555.

  5. Zhou Y, Fathali N, Lekic T, Ostrowski RP, Chen C, Martin RD, Tang J, Zhang JH. Remote limb ischemicpostconditioning protects against neonatal hypoxicischemic brain injury in rat pups by the opioid receptor. Akt pathway. 2011; 42 (2): 439-444.

  6. Khatibi NH, Ma Q, Rolland W, Ostrowski R, Fathali N, Martin R, Applegate R, Stier G, Tang J, Zhang JH. Iso urane posttreatment reduces brain injury after an intracerebral hemorrhagic stroke in mice. Anesth Analg. 2001; 113 (2): 34.

  7. Jevtovic-Todorovic V, Hartman RE, Izumi Y, Benshoff ND, Dikranian K, Zorumski CF, Olney JW, Wozniak DF. Earlyexposure to common anesthetic agents causes wide-spread neurodegeneration in the developing rat brainand persistent learning de cits. J Neurosci. 2003; 23 (3): 876-882.

  8. Karen T, Schlager GW, Bendix I, Sifringer M, Herrmann R, Pantazis C, et al. Effect of Propofol in the Immature Rat Brain on Short- and Long-Term Neurodevelopmental Outcome. PLoS ONE. 2013; 8 (5): e64480.

  9. Ferro MM, Angelucci ME, Anselmo-Franci JA, Canteras NS, Da Cunha C. Neuroprotective effect of ketamine/ xylazine on two rat models of Parkinson’s disease. Braz J Med Biol Res. 2007; 40 (1): 89-96.

  10. Hovens IB, Schoemaker RG, van der Zee EA, et al. Thinking through postoperative cognitive dysfunction: How to bridge the gap between clinical and pre-clinical perspectives. Brain Behay Immun. 2012; 26: 1169-1179.

  11. Belozertseva IV, Dravolina OА, Krivov VO, Tur MА, Polushin YS. Eksperimentalnoye modelirovaniye posleoperatsionnykh kognitivnykh rasstroystv u krys [Experimental simulation of post-operative cognitive disorders in rats]. Vestnik anesteziologii i reanimatologii [Messenger of Anesthesiology and Resuscitation]. 2017; 13 (5): 33-49. DOI 10.21292/2078-5658-2016-13-5-37-49

  12. Stratmann G. Neurotoxicity of anesthetic drugs in the developing brain. Anesthesia & Analgesia. 2011; 113(5): 1170–1179.

  13. Sharipova VH, Valihanov AA, Alimov AH, Djuraev FS. Vliyaniye obshchey anestezii na sposobnost k obucheniyu u krys [The influence of general anesthesia on learning memory of rats]. Vestnik ekstrennoy meditsiny [Bulletein of Emergency medicine]. 2019; 12 (1): 62-66.

  14. Koolhaas JM. The Laboratory Rat R Hubrecht, J Kirkwood, The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals. 2010; 8: 311-326.

  15. Bliss S. Rodent Anesthesia. Cornell University: Institutional Animal Care and Use Committee. 2016; 4 p.

  16. Judith AD. Mouse and Rat Anesthesia and Analgesia. Current Protocols in Neuroscience. 2008; A4B1-A4B21.

  17. Pritchett-Corning KR, Mulder GB, Luo Y, White WJ. Principles of Rodent Surgery for the New Surgeon. J Vis Exp. 2011; 47: e2586.

  18. Hoogstraten‐Miller SL, Brown PA. Techniques in Aseptic Rodent Surgery. Current Protocols in Immunology. 2008; 82: 1.12.1-1.12.14. doi:10.1002/0471142735.im0112s82

  19. Shoji H, Hagihara H, Takao K, Hattori S, Miyakawa T. T-maze Forced Alternation and Left-right Discrimination T asks for Assessing Working and Reference Memory in Mice. J Vis Exp. 2012; 60: e3300.

  20. Motulsky HJ. Common misconceptions about data analysis and statistics. Naunyn Schmiedebergs Arch Pharmacol. 2014; 387: 1017-1023.

  21. Belozertseva IV, Dravolina OА, Krivov VO, Tur MА, Mus LV, Polushin YS. Posleoperatsionnyye izmeneniya povedeniya krys, poluchavshikh anesteziyu sevo uranom [Postoperative changes in the behavior of rats after anesthesia with sevofurane]. Vestnik anesteziologii i reanimatologii [Messenger of Anesthesiology and Resuscitation]. 2017; 14 (2): 55-63. DOI: 10.21292/2078- 5658-2017-14-2-55-63

  22. Haseneder R, Starker L, Berkmann J, et аl. Sevo urane anesthesia improves cognitive performance in mice, but does not in uence in vitro long-term potentation in hippocampus СА1 stratum radiatum. РLоS ONE. 2013; 8 (5): е64732.

  23. Ozer М, Baris S, Karakaya D, et аl. Behavioural effects оfchronic exposure to subanesthetic concentrations of halothane, sevo urane and des urane in rats. Can J Anesth. 2006; 53 (7): 653-658.