COMPARATIVE STUDY OF EDUCATIONAL PATTERNS IN FAMILIES OF CHILDREN WITH BEHAVIORAL, SPEECH AND AUTISTIC DISORDERS

UDC 37.018.1:159.922.76

DOI: 10.20969/VSKM.2018.11(3).7-12

BELOUSOVA MARINA V., C. Med. Sci., associate professor of the Department of psychotherapy and narcology of Kazan State Medical Academy – branch of the Russian Medical Academy of Postgraduate Education, Russia, 420012, Kazan, Mushtari str., 11, tel. (843)233-34-59, e-mail: belousova.marina@mail.ru

MERKULOVA VERONICA A., faculty member of the Department of age psychology of Institute of Psychotherapy and Clinical Psychology, Russia, Moscow, 127055, 1st Miusskaya str., 22/24, block 2, tel. 8-915-329-18-75, e-mail: vero.merkulova@yandex.ru

GAVRIKOVA IRINA YU., medical psychologist of Children’s Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan, Russia, Kazan, 420138, Orenburg tract str., 140, tel. 8-90-50-23-44-78, e-mail: gira.80@mail.ru

Abstract. Educational strategies in families with children with behavioral and cognitive impairments are ofteninadequate and exacerbate disharmonious development of the child. The features of family interaction of preschool children (3 to 7 years) with behavioral disorders, speech disorders, autistic manifestations and in children of the control group were studied using the methodology of «Family relationship analysis» (FRA), developed by V. Justitskis and E.G. Eidemiller. Material and methods. Conducted research includes quantitative estimation and qualitative interpretation of the received data. Questioning, test, phenomenological and statistical research methods were applied. Results and discussion. A high degree of severity of family interaction strategy violations was revealed in all studied groups. The most common and typical for families of all groups are the following pathological educational patterns: hyperopic (143; 49,5%) (р=0,000), insufficiency of prohibition requirements (142; 49,1%) (р=0,000), insufficiency of sanctions (133; 46,0%) (р=0,000), lack of requirements – duties (124; 42,9%) (р=0,000). The frequency of upbringing violations is caused by a shift in the parents’ attitudes to the child depending on his gender – in particular, the preference for the female qualities in boys. The study of family upbringing parameters has revealed the tendencies of unharmonious family education as indulgent hyperprotection in all groups. Ineffective parental strategy has been noted in a large number of cases in all 3 study groups and it is an indication for subsequent corrective work with the family system aimed at increasing the effectiveness of child-parent interaction and at the optimization of the «requirements/prohibitions», «ignoring/indulgence» ratios, improving the understanding of the child’s needs and own opportunities to influence his behavior and speech activity. Conclusion. The results of the study can be used to identify ineffective parental strategies that not only affect the state of the family system as a whole, but also aggravate the behavioral, speech and communication problems of the child, which creates the need in psychological correctional assistance to the family.

Key words: family relationship analysis, family care, early childhood education, behavioral disorders in children, speech disorders, autistic disorders.

For reference: Belousova MV, Merkulova VA, Gavrikova Yu. Comparative study of educational patterns in families of children with behavioral, speech and autistic disorders. The Bulletin of Contemporary Clinical Medicine. 2018; 11 (3): 7–12. 10.20969/VSKM.2018.11(3).7-12.

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 MONITORING OF THE INFLUENCE OF SOCIAL AND ECONOMIC FACTORS ON THE HEALTH OF POPULATION IN THE LARGE MEGAPOLIS

UDC 614.1(470.41-25)

DOI: 10.20969/VSKM.2018.11(3).13-19

GALIULLIN AFGAT N., D. Med. Sci., professor of the Department of health management of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, e-mail: kybm@mail.ru

SHAMSIYAROV NURIKHAN N., D. Med. Sci., Vice-manager on organizational and methodical work of Medical and diagnostic center of Kazan, Russia, 420041, Kazan, Yu. Fucik str., 72 

SHULAEV ALEXEY V., D. Med. Sci., professor, Vice-rector for interaction with training and production facilities and clinical affairs, Head of the Department of general hygiene of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49

GALIULLIN DAMIR A., deputy chief physician of Kazan City Hospital № 16, Russia, 420039, Kazan, Gagarin str., 121 KHUSAINOVA GUZEL A., 5-year student of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49

Abstract. Aim. The impact of socio-economic living conditions on medical and demographic indicators and socially significant diseases among the population of Kazan in 1995–2016 during socioeconomic reforms was studied in the context of socio-hygienic monitoring. Material and methods. The influence of socio-economic living conditions on fertility, mortality, life expectancy, prevalence of tuberculosis, cancer morbidity, mental and addictive disorders, HIV infection and disability in 1995–2016 was studied. Results and discussion. As a result of this monitoring it was found that the low level of the gross regional product for the 1st (1995–1998) and the 2nd (1999–2006) observation periods did not significantly affect the birth rate (ηA2=1,2%; p>0,05 and ηA2=1,4%; p>0,05 respectively). In the 3rd period (2006–2016) this factor had a significant effect on the fertility rate (ηA2=2,8%; p<0,05). It was revealed thatthe low levels of economic parameters significantly influenced mortality rate in the working-age population. The most significant positive impact was on the indicators of life expectancy with a significant revival of economic conditions in the city of Kazan, the presence of a high level of housing construction in 2006–2016 (p<0,001). Due to the growing economic potential of the city there was a significant decrease of the influence of these factors on the prevalence of tuberculosis (p<0,001), which decreased by 41%. The impact of economic factors on cancer morbidity with the growth of economic living conditions reduced to 24,2%. The total impact of economic conditions led to a significant decrease in mental or addictive disorders or infectious morbidity rate to 12,1%. Economic factors were also significantly affected by the decrease in mortality from 262,1 in 1995 to 23,8 cases in 2016, during this period morbidity with temporary disability reduced by 34,3 cases, 434,6 days per 100 workers, disability rates decreased from 110,1 in 1995 to 50,3 cases in 2016. The impact of economic factors on HIV infection increased by 5,2% (p<0,05). Conclusion. With the help of variance analysis it was established that the economic development factors for the 3 time periods (1995–1998, 1999–2005 and 2005–2016) were differently influenced by medical and demographic indicators of health and morbidity in the population of the city of Kazan.

Кeу words: socio-economic factors, the power of the influence of economic factors, variance analysis, socio-hygienic monitoring, birth rate, mortality, life expectancy.

For reference: Galiullin AN, Shamsiyarov NN, Shulaev AV, Galiullin DA, Khusainova GA. Monitoring of the influence of social and economic factors on the health of population in the large megapolis. The Bulletin of Contemporary Clinical Medicine. 2018; 11 (3): 13–19. D01: 10.20969/VSKM.2018.11(3).13-19.

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 PARAMETRIC VARIATION OF MICROCIRCULATION AFFECTED BY TES-THERAPY

UDC 616.16:615.84

DOI: 10.20969/VSKM.2018.11(3).20-26

ZARUBINA ELENA G., D. Med. Sci., professor, Vice-rector for educational work, Head of the Department medical and biological discipline, Medical University «REAVIZ», Russia, 443001, Samara, Chapaevskaya str., 227, tel. +7(846)333-54-51, e-mail: mail@reaviz.ru

SHALDYBINA YULIA E., postgraduate student of the Department of internal medicine, Medical University «REAVIZ», Russia, 443001, Samara, Chapaevskaya str., 227, tel. +7(846)333-54-51, e-mail: 888mf@mail.ru

PROKHORENKO INGA O., D. Med. Sci., associate professor, the 1st Vice-rector for educational work, Medical University «REAVIZ», Russia, 443001, Samara, Chapaevskaya str., 227, tel. +7(846)333-54-51, e-mail: mail@reaviz.ru

Abstract. Aim. The effect of TES-therapy on the condition of microcirculatory blood flow was studied in patients with somatic comorbid diseases – chronic obstructive pulmonary disease (COPD) and systemic arterial hypertension (AH). Material and methods. Degree of microcirculation process disturbance was investigated using laser flowmetry with
«LAKK-M» diagnostic complex. The following parameters were evaluated: the average perfusion value, mixed (capillary) blood saturation, arterial blood saturation, relative volume of erythrocyte fraction in the middle fingertip, the index of perfusion oxygen saturation in the microcirculation, the index of specific oxygen consumption in the tissue, the efficiency of oxygen exchange, the fluorescence indicator of oxygen consumption. TES-therapy was applied for 1.5 years in order to correct the revealed violations. Results and discussion. Treated patients with comorbid diseases had a reduced index of perfusion saturation in the microcirculation by an average of 9% (р≤0,05), an increased oxygen consumption in tissues, which metabolism efficiency has increased, and decreased activity of glycolytic processes. There was an increase in the fluorescent indicator of oxygen consumption by 6,2, 9,8 and 9,0% (p1-3≤0,05), respectively, depending on
the duration of the history of COPD – up to 5, 10 or 15 years. Conclusion. The effect of TES-therapy on microcirculatory disorders is realized through an increase in the duration of adaptation mechanisms aimed at combating hypoxia against comorbid disease, especially in case of a less than 10 year history of the disease. Increase in the microcirculatory bloodstream capacity by reducing the precapillary tonus and by opening reserve microcirculation vessels leads to systemic AH reduction in comorbid disease.

Кeу words: chronic obstructive pulmonary disease, systemic arterial hypertension, microcirculation, CES-therapy.

For reference: Zarubina EG, Shaldybina YuE, Prokhorenko IO. Parametric Variation of Microcirculation affec- ted by TES-therapy. The Bulletin of Contemporary Clinical Medicine. 2018;11 (3): 20–26. D01: 10.20969/ VSKM.2018.11(3).20-26.

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 RIGHT VENTRICLE LONGITUDINAL DEFORMATION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS WITH DIFFERENT BODY WEIGHT

UDC 616.124.3:616.24-036.12 

DOI: 10.20969/VSKM.2018.11(3).26-31

KOSTAREVA ROZA A., postgraduate student of the Department of internal medicine and family medicine of E.A. Wagner Perm State Medical University, Russia, 614990, Perm, Petropavlovskaya str., 26, tel. + 7-908-279-77-75, e-mail: roza-kostareva@mail.ru

KHOVAEVA YAROSLAVA B., D. Med. Sci., professor, Head of the Department of internal medicine and family medicine of E.A. Wagner Perm State Medical University, Russia, 614990, Perm, Petropavlovskaya str., 26, tel. (342) 217-20-80, fax: (342) 217-20-80, e-mail: yaroslavakh@rambler.ru

PODJANOVA ANNA I., postgraduate student of the Department of internal medicine and family medicine of E.A. Wagner Perm State Medical University, Russia, 614990, Perm, Petropavlovskaya str., 26, tel. (342) 217-20-80, fax: (342) 217-20-80, e-mail: podyanova00@mail.ru

GOLOVSKOY BORIS V., D. Med. Sci., professor of the Department of internal medicine and family medicine of E.A. Wagner Perm State Medical University, Russia, 614990, Perm, Petropavlovskaya str., 26, tel. (342) 217-20-80, fax: (342) 217-20-80, e-mail: fuvpgma@mail.ru

SYROMYATNIKOVA TATYANA N., C. Med. Sci., associate professor of the Department of internal medicine and family medicine of E.A. Wagner Perm State Medical University, Russia, 614990, Perm, Petropavlovskaya str., 26, tel. (342) 217-20-80, fax: (342) 217-20-80, e-mail: fuvpgma@mail.ru

ERMACHKOVA LARISA V., C. Med. Sci., associate professor of the Department of internal medicine and family medicine of E.A. Wagner Perm State Medical University, Russia, 614990, Perm, Petropavlovskaya str., 26, tel. (342) 217-20-80, fax: (342) 217-20-80, e-mail: fuvpgma@mail.ru

Abstract. Aim. To evaluate right ventricle longitudinal deformation in chronic obstructive pulmonary disease patients with different body weight. Material and methods. 72 chronic obstructive pulmonary disease patients [mean age (64,6±1,0) years; 83,3% men] were divided into 3 groups according to the body mass index: group 1 – patients with normal body weight (n=31), group 2 – overweight patients (n=21), group 3 – patients with obesity, Class I and II (n=20). All patients underwent echocardiography with global and segmental right ventricle free wall systolic longitudinal deformation evaluation («VIVID-7», GE). Subcutaneous and premesenteric fat thickness was assessed via ultrasound. Results and discussion. Global right ventricle free wall longitudinal deformation decreases, as well as its regional deformation at all 3 levels in patients with chronic obstructive pulmonary disease with increased body mass index. It was revealed that right ventricle global longitudinal deformation is reduced in the 2nd and the 3rd groups. Strong direct association was found between right ventricle free wall global longitudinal deformation (F1=0,81) with premesenterial fat thickness (F1=0,53) and body mass index (F1=0,50) in groups 2 and 3 according to factor analysis. Conclusion. Right ventricle global longitudinal deformation reduction in chronic obstructive pulmonary disease patients with excessive weight and obesity might act as early marker of its systolic dysfunction. Worsening of the right ventricle global longitudinal systolic deformation in chronic obstructive pulmonary disease patients with excessive weight and obesity is associated with the increase of body mass index and premesenterial fat thickening. 

Кeу words: chronic obstructive pulmonary disease, body mass index, right ventricle, longitudinal deformation.

For reference: Kostareva RA, Khovaeva YB, Podjanova AI, Golovskoy BV, Syromyatnikova TN, Ermachkova LV. Right ventricle longitudinal deformation in chronic obstructive pulmonary disease patients with different body weight. The Bulletin of Contemporary Clinical Medicine. 2018; 11 (3): 26–31. D01: 10.20969/VSKM.2018.11(3).26-31.

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1. Tanchenko ОА, Naryshkina SV. Ozhirenie, metaboliches- kie narushenija iarterial’naja gipertonija u bol’nyh hronicheskoj obstruktivnoj bolezn’ju legkih, sovremennye predstavlenija o komorbidnosti [Obesity, metabolic disorders and arterial hypertension in patients with chronic obstructive pulmonary disease, modern concepts of comorbidity]. Bjulleten’ fiziologii i patologii dyhanija [The Bulletin of Physiology and Pathology of Breathing]. 2016; 59: 109-118.

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8. Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2015; 28: 1-39.

9. Suzuki R, Watanabe S, Hirai Y et al. Abdominal wall fat index, estimated by ultrasonography, for assessment of the ratio of visceral fat to subcutaneous fat in the abdomen. Am J Med. 1993; 95: 309-314.

 

 СLINICAL AND IMMUNOLOGICAL FEATURES OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ITS COMBINATION WITH COMMUNITY ACQUIRED PNEUMONIA

UDC 616.24-036.12

DOI: 10.20969/VSKM.2018.11(3).31-36

FARKHUTDINOV USMAN R., D. Med. Sci., professor of the Department of introduction to internal medicine of Bashkir State Medical University, Russia, 450000, Ufa, Lenin str., 3, tel. 8 (3472) 72-41-73; Head of the Department of pulmonology of City Clinical Hospital № 21, Russia, 450071, Ufa, Lesnoy proezd str., 3, tel. 8 (3472)32-32-88, e-mail: babe@bk.ru

AMIROVA ELMIRA F., physician of the Department of pulmonology of City Clinical Hospital № 21, Russia, 450071, Ufa, Lesnoy proezd str., 3, tel. 8 (3472)32-32-88, e-mail: elmira008@bk.ru

Abstract. Aim. The features of the clinical course and immunologic status were determined in patients with chronic obstructive pulmonary disease and in its combination with community acquired pneumonia. Material and methods. 55 patients with chronic obstructive pulmonary disease were enrolled into the study. The 1st group included patients with exacerbation of chronic obstructive pulmonary disease (n=28). The patients who had the disease combined with community-acquired pneumonia entered the 2nd group (n=27). Clinical symptoms of the disease, the state of cellular and humoral immunity, phagocyte activity of blood neutrophils, production of interleukin-6 and tumor necrosis factor-α (TNF-α) have been determined in the patients within the study. Results and discussion. The patients with chronic obstructive pulmonary disease and community acquired pneumonia have demonstrated higher intensity of respiratory symptoms, higher level of C-reactive protein and lower spirometric parameters. Compared to the patients with chronic obstructive pulmonary disease these patients have shown reduced activity of T-helpers and T-suppressors and increased levels of B-lymphocytes, Ig M, interleucin-6, and TNF-α. Frank symptoms of the disease and manifestations of the systemic origin, lower amount of NK-cells and IgG, higher levels of B-lymphocytes, IgM, interleucin-6 and TNF-α have been preserved in patients with chronic obstructive pulmonary disease and community acquired pneumonia during the course of treatment. Conclusion. The course of the disease in patients with chronic obstructive pulmonary disease and chronic obstructive pulmonary disease combined with community acquired pneumonia is associated with immunological impairment. Frank clinical symptoms and immune response impairment have been preserved after the course of treatment in patients with chronic obstructive pulmonary disease combined with community acquired pneumonia.

Кeу words: community acquired pneumonia, chronic obstructive pulmonary disease, immune status.

For reference: Farkhutdinov UR, Amirova EF. Clinical and immunological features of chronic obstructive pulmonary disease and its combination with community acquired pneumonia.The Bulletin of Contemporary Clinical Medicine. 2018; 11 (3): 31–36. D01: 10.20969/VSKM.2018.11(3).31-36.

References

1. Global Initiative for Chronic Obstructive Lung Disease. 2016; http: // goldcopd.org

2. Rastopina NA, Shuganova EG, Paleev FN, Salmasi ZhM, Shuganov AE. Rol’ citotoksicheskih limfocitov v vospalenii u bol’nyh hronicheskoj obstruktivnoj bolezn’ju legkih v stadijah obostrenija i remissii [The role of cytotoxic lymphocytes in inflammation in patients with chronic obstructive pulmonary disease in the stages of exacerbation and remission]. Al’manah klinicheskoj mediciny [Al’manah klinicheskoj mediciny]. 2014; 35: 49-53.

3. Shihnebiev D. Osobennosti kliniki i diagnostiki vne- bol’nichnyh pnevmonij, razvivshihsja na fone hronicheskoj obstruktivnoj bolezni legkih [Features of the clinic and diagnosis of community-acquired pneumonia, devel Labora oped against a background of chronic obstructive pulmonary disease]. Sovremennye problemy nauki i obrazovanija [Modern problems of science and education]. 2014; 2: https://www.science-education.ru/ru/article/ view?id=12720

4. Kuzubova NA, Titova ON, Volchkov VA, Kozyrev AG. Osobennosti vnebol’nichnoj pnevmonii u pacientov s hronicheskoj obstruktivnoj bolezn’ju legkih [Features of community-acquired pneumonia in patients with chronic obstructive pulmonary disease]. Trudnyj pacient [Difficult patient]. 2014; http://t-pacient.ru/articles/8163/

5. Chuchalin AG, Sinopal’nikov AI, Kozlov RS, Tjurin IE, Rachina SA. Vnebol’nichnaja pnevmonija u vzroslyh: prakticheskie rekomendacii po diagnostike, lecheniyu i profilaktike [Non-pneumonia pneumonia in adults: practical recommendations for diagnosis, treatment and prevention]. Infekcionnye bolezni: Novosti; Mneniya; Obuchenie [Infectious Diseases: News; Opinions; Training]. 2013; 2 (3): 91-123.

6. Charlson ME , Pompei P, Ales KL, McKenzie CR. A new method classifying prognostic comorbidity in longitudinal studies: development and validation. J Chron Dis. 1987; 40 (5): 373-383.

7. Bestal JC, Paul EA, Jones PW, et al. Usefulness of the Medical Research Council (MRS) dyspnea scale as a measure of disability in patients with chronic obstructive pulmonary disease. Thorax. 1999; 54: 581-586.

8. Kunicina JuL, Shmelev EI. Protivovospalitel’naja terapija bol’nyh pri hronicheskoj obstruktivnoj bolezni legkih [Anti- inflammatory therapy of patients with chronic obstructive pulmonary disease]. Pul’monologija [Pulmonology]. 2003; 2: 111-116.

9. Bairamgulov FA, Bulgakova AD, Bikmetova NR, Kure- lenkova ME. Opyt primeneniya protochnoi tsitometrii v praktike raboty kliniko-diagnosticheskoi laboratorii [Experience in the application of flow cytometry in the practice of the clinical diagnostic laboratory]. Ufa: Aktual’nye voprosy povysheniya kvalifikatsii vrachei i provizorov; novye tekhnologii v meditsine [Ufa: Actual questions of the professional development of doctors and pharmacists; new technologies in medicine.]. 2001: 98-99.

10. Men’shikova VV ed. Metodiki klinicheskikh laboratornykh issledovanii: spravochnoe posobie [Methods of clinical laboratory research: reference manual]. Moskva: Labora [Moscow: Laboratories]. 2009; 3: 880 p.

11. Mancini G, Garbonara A, Heremans G. Immunological quantitation of antigens by single radial immunodiffusion. Immunochemestry.1965; 2 (3): 235-254.
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13. Anthonisen NR , Manfreda J, Warren CP, et al. Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann Intern Med. 1987; 106: 196-204. doi: 10.1007/s00108-011-2863-y

14. Mirhajdarov AM. Osobennosti processov svobodno- radikal’nogo okislenija i immunologicheskoj reaktivnosti, korrekcija ih narushenij pri vnebol’nichnoj pnevmonii [Features of processes of free radical oxidation and immunological reactivity, correction of their disorders in community-acquired pneumonia]. Ufa. 2015; 22 p.

 

 LUNG FUNCTION AND BLOOD GAS COMPOSITION DISTURBANCE IN PATIENTS WITH ROUND LUNG MASS

UDC 616.24-008.4

DOI: 10.20969/VSKM.2018.11(3).37-44

SHERGINA ELENA A., C. Med. Sci., Head of the Department of functional diagnostics of Central Research Institute of Tuberculosis, Russia, 107564, Moscow, Yauzskaya lane, 2, e-mail: e.a.sher@yandex.ru

STEPANYAN IGOR E., ORCID//orcid.org/0000-0002-2985-3379, D. Med. Sci., professor, medical advisor, leading research worker of Central Research Institute of Tuberculosis, Russia, 107564, Moscow, Yauzskaya lane, 2, e-mail: drstepanyan@mail.ru

KARPINA NATALYA L., D. Med. Sci., Head of the Department of clinical diagnostics of Central Research Institute of Tuberculosis, Russia, 107564, Moscow, Yauzskaya lane, 2, e-mail: natalya-karpina@rambler.ru

POPOVA LIDIYA A., C. Med. Sci., senior research worker of the Department of clinical diagnostics of Central Research Institute of Tuberculosis, Russia, 107564, Moscow, Yauzskaya lane, 2

KASIMTSEVA SVETLANA A., C. Med. Sci., researcher worker of the Department of pulmonary tuberculosis differential diagnosis and extracorporeal treatment of Central Research Institute of Tuberculosis, Russia, 107564, Moscow, Yauzskaya lane, 2, e-mail: skasimtseva@mail.ru

ADAMOVSKAYA EVGENIYA N., clinical resident of the Department of pulmonary tuberculosis differential diagnosis and extracorporeal treatment of Central Research Institute of Tuberculosis, Russia, 107564, Moscow, Yauzskaya lane, 2, e-mail: janee1709@gmail.com

ERGESHOV ATADZHAN E., D. Med. Sci., professor, Director of Central Research Institute of Tuberculosis, Russia, 107564, Moscow, Yauzskaya lane, 2, e-mail: cniit@ctri.ru

Abstract. Aim. The aim of the study was to assess the results of lung function and blood gases tests in patients with round lung mass. Material and methods. 112 patients with round lung mass of different origin were enrolled in the study. According to the results of the main diagnostic methods of the study: chest computer tomography, fibrobronchoscopy with a complex of biopsies, lung resections with subsequent histological, bacteriological and molecular genetic verification of the nature of the mass, all patients were divided into 4 main groups: tuberculosis, benign tumors, malignant tumors, round lung mass of other origin. Lung functional studies and blood gases measurement were performed in all patients at admission. Results and discussion. Lung functions and blood gases test disturbance was revealed in all groups of patients with round lung mass. Lung ventilating function reduction was observed significantly less often in patients with tuberculomas than in ones with malignant tumors (21,2 and 66,1%). Gas exchange abnormalities were diagnosed in more than a third of patients with tuberculosis and malignant tumors (37,9 and 41,7%). The presence of concomitant chronic respiratory diseases showed a significant influence on the results of lung function tests. Conclusion. The study revealed that a purposeful examination reveals violations of lung ventilation function and blood gas composition in a significant number of patients with limited and mostly asymptomatic round lung mass. The severity of the disturbances depends both on the nature of the round lung mass and on the presence of concomitant chronic respiratory diseases. 

Key words: round lung mass, pulmonary tuberculosis, lung tumors, spirometry, blood gases.

For reference: Shergina EA, Stepanyan IE, Karpina NL, Popova LA, Kasimtseva SA, Adamovskaya EN, Ergeshov AE. Lung function and blood gas composition disturbance in patients with round lung mass. The Bulletin of Contemporary Clinical Medicine. 2018; 11 (3): 37–44. DOI: 10.20969/VSKM.2018.11(3).37-44.

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1. Shika LL, Kanaeva NN ed. Obshchie voprosy metodiki issledovaniya i kriterii ocenki pokazatelej dyhaniya [General questions of the research methodology and criteria for assessing respiration rates]. Leningrad: Medicina [Leningrad: Medicine]. 1980; 21-36.

2. Mellemgaard K. The alveolar-arterial oxygen difference: its size and components in normal man. Acta Physiol Scand. 1966; 67: 10-20.

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4. Alekseev MI, Borohov AI, Zamotaev IP et al. Chastnaya pul’monologiya, tom 2; Bolezni organov dyhaniya: Rukovodstvo dlya vrachej v 4 tomakh, pod redakciey NR Paleeva [Private Pulmonology, Volume 2; Diseases of the respiratory system: A guide for doctors in 4 tons, NR Paleev ed.]. Moskvsa: Medicina [Moscow: Medicine]. 1989; 512 p.

5. Chuchalina AG ed. Federal’nye klinicheskie rekomendacii po ispol’zovaniyu metoda spirometrii [Federal clinical guidelines for the use of the spirometry method]. Pul’monologiya [Pulmonology]. 2014; 6: 11-24.

6. Bychkov MB, Gorbunova VA. Federal’nye klinicheskie rekomendacii po diagnostike i lecheniyu bol’nyh rakom legkogo [Federal clinical guidelines for the diagnosis and treatment of patients with lung cancer]. Moskva: Obshcherossijskij soyuz obshchestvennyh obedinenij; associaciya onkologov Rossii [Moscow: All-Russian Union of Public Associations; Association of Oncologists of Russia,]. 2014; 26 p.

7. Slavkovska K. Krvne plyny a acidobazicka rovnovaha; Kristuffek P a kol Funkcia dychania v laboratornej a klinickej praxi. Vidavatelstvo Osveta. 1982; 124-156.

8. Report Working Party European Community for Steel and Coal. Standardization of Lung Function Tests; official statement of European Respiratory Society. Eur Respir J. 1993; 16: 1-121.

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 ALBENDAZOL IDENTIFICATION IN TERMS OF CHEMICAL-TOXICOLOGICAL ANALYSIS

UDC 615.28.07

DOI: 10.20969/VSKM.2018.11(3).44-50

SHORMANOV VLADIMIR K., ORCID iD: orcid.org/0000-0001-8872-0691; SCOPUS Author ID: 7004388265, D. Pharm. Sci., professor of the Department of pharmaceutical, toxicological and analytical chemistry of Kursk State Medical University, Russia, Kursk, K. Marx str., 3, tel. 8 (4712) 58-13-23

SHCHERBAKOV DENIS P., part-time postgraduate student of the Department of pharmaceutical, toxicological and analytical chemistry of Kursk State Medical University, Russia, Kursk, K. Marx str., 3, tel. 8 (4712) 58-13-23, e-mail: D.Sherbakov90@yandex.ru

Abstract. Albendazole is an antiparasitic medication, mainly used to combat helminths. It is widely used in medicine and veterinary medicine and has a number of side effects such as teratogenicity, hematotoxicity and serious dyspeptic disorders in case of prolonged use. Aim.The features of albendazole identification have been studied in terms of chemical-toxicological analysis. Material and methods. A number of model mixtures of albendazole (25 mg) with liver (25 g) have been prepared. A possibility of extracting albendazole from biological material with various solvents has been studied. Optimal multiplicity and isolation time, as well as volume, were found for the best agent exctracting albendazol. Later, dependence of completeness of extraction on the value of the content of albendazole in different ratios was revealed. A type of additional purification by column chromatography was studied. Thin layer chromatography method is proposed in the biomaterial for preliminary albendazole identification, chromatographic mass spectrometry and ultraviolet spectrometry methods have been used for the confirmatory analysis, which we also used to determine the quantitative content of albendazole. Results and discussion. Acetone was chosen as the best agent for extracting albendazole from model mixtures (extraction degree 86,7%), the amount of the agent must massively exceed the amount of biomaterial by 2 times (50 g or 62,5 ml), the infusion was carried out twice for 45 min. Optimal systems were chosen for column chromatography (acetone-dichloromethane (9,0: 1,0), yield in 11–17 fractions) and for thin layer chromatography (acetonitrile-toluene (7:3), Rf – 0,63±0,02). The features of albendazole identification by the method of gas chromatography with mass-selective detection, as well as the method of spectrophotometry in the iltraviolet region (A=0,004518002 × C+0,000770492 – type of calibration curve) have been studied. Conclusion. The conditions and the procedure for extracting albendazole from biological material by acetone have been determined. Further purification of the isolate obtained from the coextractive compounds and quantitative analysis of the analyte in this isolate by ultraviolet spectrophotometry has been developed. The developed methodology meets all validation criteria and can be used in practical analysis.

Key words: albendazole, isolation, purification, identification and definition.

For reference: Shormanov VK, Shcherbakov DP. Albendazole identification in terms of chemical-toxicological analysis. The Bulletin of Contemporary Clinical Medicine. 2018; 11 (3): 44–50. DOI: 10.20969/VSKM.2018.11(3).44-50.

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2. Khromova SN. Izucheniye ostroy toksichnosti mikro- kapsulirovannogo al’bendazola [Study of the acute toxicity of microencapsulated albendazole]. Materialy doklada nauchnoy konferentsii Vserossiyskogo obshchestva gel’mintologov RAN «Teoriya i praktika bor’by s pa- razitarnymi boleznyami» [Proceedings of the report of the scientific conference of the All-Russian Society of Helminthologists of RAS «Theory and practice of fighting parasitic diseases]. 2006; 7: 431-432.

3. Sharma K, Kandaswamy M, Mithra C еt al. Highly sensitive LC-MS/MS-ESI method for simultaneous quantitation of albendazole and ricobendazole in rat plasma and its application to a rat pharmacokinetic study. Biomed. Chromatogr. 2012; 26 (32): 247-255.

4. Shormanov VK, Astashkina AP, Tarasova OV, Sukhomlinov YuA, Pugacheva OI, Orekhova LO. Opredeleniye monogidroksiarenov metodom TSKh [Determination of monohydroxyarenesby TLC]. Sorbtsionnye i khro- matograficheskiye protsessy [Sorption and chromatogra- phic processes]. 2017; 17 (4): 648-656.

5. Shormanov VK, Shcherbakov DP. Opredeleniye alben- dazola v biomateriale [Determination of albendazole in a biomaterial]. Tyumen: sbornik nauchnykh trudov po itogam mezhdunarodnoy nauchno-prakticheskoy konferentsii «Novshestva v meditsine i farmakologii» [Tyumen: Collection of scientific papers on the results of aninternational scientific and practical conference «Innovations in medicine and pharmacology»]. 2017; 2: 26-28.

6. Shormanov VK, Shcherbakov DP. Opredeleniye meben- dazola v krovi [Determination of mebendazole in the blood]. Ufa: Sbornik nauchnykh trudov po itogam mezhdunarodnoy nauchno-prakticheskoy konferentsii «Novshestva v meditsine i farmakologii» [Ufa: Collection of scientific papers on the results of aninternational scientific and practical conference «Innovations in medicine and pharmacology»]. 2017; 4: 67.

 

REVIEWS

 ARTERIAL HYPERTENSION IN PREGNANCY AT INTERNAL MEDICINE CLINIC

UDC 618.3-06:616.12-008.331.1(048.8)

DOI: 10.20969/VSKM.2018.11(3).51-59

ABDRAKHMANOVA ALSU I., C. Med. Sci., associate professor of the Department of clinical medicine fundamental basis of Institute of biology and fundamental medicine of Kazan Federal University, Russia, 420012, Kazan, K. Marx str., 74, e-mail: alsuchaa@mail.ru

AMIROV NAIL B., ORCID ID: orcid.org/0000-0003-0009-9103; SCOPUS Author ID: 7005357664, D. Med. Sci., professor of the Department of general medical practice № 1 of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, e-mail: namirov@mail.ru

TSIBULKIN NIKOLAY A., C. Med. Sci., associate professor of the Department of cardiology, roentgen-endovascular and cardiovascular surgery of Kazan State Medical Academy – branch of the FSBEI APE RMACPE MOH, Russia, 420012, Kazan, Butlerov str., 36

GAIFULLINA RAUSHANIA F., C. Med. Sci., associate professor of the Department of clinical medicine fundamental basis of Institute of biology and fundamental medicine of Kazan Federal University, Russia, 420012, Kazan, K. Marx str., 74

Abstract. Aim. Analysis of the latest publications devoted to the features of classification, diagnostics and treatment of arterial hypertension in pregnant women has been performed. Material and methods. Review of publications in scientific and medical literature devoted to arterial hypertension in pregnancy was carried out. Results and discussion. Arterial hypertension in pregnancy is the most frequent extragenital disorder. There are 2 main types common for pregnancy. Those are hypertension that has started before pregnancy (chronic hypertension) and arterial hypertension developed during gestational period (gestational arterial hypertension). Defining moderate and severe degree of hypertension in pregnancy is important for assessing prognosis and choosing the tactics for treatment and obstetric care. Pharmacotherapy has to be avoided during the 1st trimester of pregnancy. General principles of drug treatment of hypertension in pregnant women are maximum effectiveness for the mother and safety for the fetus; starting the treatment with a minimum dose of one drug; transition to drugs of another class in insufficient effect of treatment after increasing the dose of the 1st drug or in its poor tolerability. 3 groups of drugs are used for arterial hypertension treatment in pregnancy. Those are central action drugs, calcium antagonists of dihydropyridine series and cardioselective β-blockers. When prescribing therapy doctor should be aware of the risk of excessive blood pressure reduction, which can cause a violation of the placenta perfusion and deterioration of the fetus. In addition to diagnosis and treatment of any clinical types of arterial hypertension, preventive measures are required. Those are lifestyle modification, fighting bad habits and metabolic disorders correction. Conclusion. In pregnancy, in addition to timely diagnosis and adequate treatment of any clinical types of hypertension, preventive measures are also required, such as: modification of lifestyle, fighting bad habits and metabolic disorder correction that have to be taken at the stages of planning pregnancy. This allows improving prognosis not only during pregnancy, but also at subsequent stages of a woman’s life.

Key words: arterial hypertension, essential hypertension, pregnancy, diagnosis, treatment.

For reference: Abdrakhmanova AI, Amirov NB, Tsibulkin NA, Gaifullina RF. Arterial hypertension in pregnancy at internal medicine clinic. The Bulletin of Contemporary Clinical Medicine. 2018; 11 (3): 51–59. DOI: 10.20969/ VSKM.2018.11(3).51-59.

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17. Gajsyonok OV, Zamyatina OA, Denisova NY. et al. Lechenie arterial’noj gipertonii u beremennyh: klinicheskie rekomendacii i primery [Treatment of arterial hypertension in pregnant women: clinical recommendations and examples Treatment of arterial hypertension in pregnant women: clinical recommendations and examples]. Racional’naya farmakoterapiya v kardiologii [Rational pharmacotherapy in cardiology]. 2014; 10 (4): 411- 415.

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19. Abdrahmanova AI, Amirov NB, Cibul’kin NA. Medikamen- toznoe lechenie arterial’noj gipertenzii i ego pobochnye effekty u pacientov starshego vozrasta // Vestnik sovremennoj klinicheskoj mediciny. 2016; (2): 110- 116.

20. Yagfarova RR, Amirov NB. Primenenie kombinirovannogo preparata perindopril i indapamid v lechenii bol’nyh arterial’noj gipertenziej [The use of a combined drug perindopril and indapamide in the treatment of patients with hypertension]. Vestnik sovremennoj klinicheskoj mediciny [Herald of modern clinical medicine]. 2008; 1: 60-64.

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23. Diagnostika i lechenie arterial’noj gipertenzii: klinicheskie rekomendacii [Diagnosis and treatment of hypertension: Clinical recommendations]. M; 2013: 64.

24. Rhodes CA, Beevers DG, Churchill D. A randomized trial of ambulatory blood pressure monitoring versus clinical blood pressure measurement in the management of hypertension in pregnancy. A feasibility study. Pregnancy Hypertens. 2018;11: 142-144.

25. Varnier N, Brown МА, Reynolds M. et al. Indications for delivery in pre-eclampsia. Pregnancy Hypertens. 2018; 11: 12-17.

 

 INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN – BARR VIRUS: CLINICAL AND PATHOGENIC ASPECTS (review)

UDC 616.98:578.825.13(048.8)

DOI: 10.20969/VSKM.2018.11(3).59-65

DROZDOVA NAILYA F., postgraduate student of the Department of infectious diseases of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. +7(904)-675-70-41, e-mail: nelya89@bk.ru

FAZYLOV VILDAN KH., D. Med. Sci., professor of the Department of infectious diseases of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, e-mail: vildan47@rambler.ru

Abstract. Epstein – Barr virus and infectious mononucleosis are synonymous for many physicians. Epstein – Barr virus causes approximately 90% of cases of infectious mononucleosis, while the rest of the cases are associated mainly with cytomegalovirus, human herpesvirus type 6, toxoplasmosis, HIV infection and adenovirus. Aim. Pathogenetic, clinical and epidemiological features of Epstein – Barr virus infectious mononucleosis have been analyzed as well as the problems of its diagnosis and treatment. Material and methods. The article presents an overview of Russian and foreign literature data on Epstein – Barr virus infectious mononucleosis. Results and discussion. In connection with significant increase in the incidence of infectious mononucleosis caused by Epstein – Barr virus in recent years, improvement of specific diagnostic methods and antiviral therapy will successfully solve the problem of arresting pathological process at the early stages of the disease. However, the problem of chronic forms of the disease requires in-depth study. Conclusion. The key to success in treatment of patients with infectious mononucleosis is timely diagnosis, correct individual approach to etiotropic and pathogenetic therapy, as well as timely hospitalization of patients with severe forms of infectious mononucleosis.

Key words: infectious mononucleosis; Epstein – Barr virus; hepatitis.

For reference: Drozdova NF, Fazylov VH. Infectious mononucleosis caused by Epstein – Barr virus: clinical and pathogenic aspects (review). The Bulletin of Contemporary Clinical Medicine. 2018; 11 (3): 59–61. DOI: 10.20969/ VSKM.2018.11(3).59-61.

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 THE FEATURES OF PAIN DIAGNOSTICS IN PATIENTS WITH BLOOD SYSTEM DISEASES

UDC 616.8-009.7-07:616.15(048.8)

DOI: 10.20969/VSKM.2018.11(3).65-76

LEVCHENKO OLGA K., ORCID ID: orcid.org/0000-0003-1425-4370, C. Med. Sci., senior researcher of the Department of intensive care and resuscitation of National Research Center of Hematology, Russia, 125167, Moscow, Novyi Zykovsky proezd, 4, tel. 8-926-816-38-87, e-mail: levchenkokp@rambler.ru

BERSENEVA EVGENIA A., D. Med. Sci., Head of the Center of higher and additional professional education of N.A. Semashko National Public Health Research Institute, Russia, 105064, Moscow, Vorontsovo Pole str., 12, bld. 1

Abstract. Diseases of the blood system are associated with acute and chronic pain along with other disorders. According to different authors, sharp pain occurs in 52-76% of patients with oncohematological diseases. Pain management is an indicator of the quality of medical care in developed countries. One of the reasons for inadequate pain relief in hematological patients may be insufficient pain assessment or control. Aim. Analysis and systematization of various diagnostic tools suitable for routine use in patients with blood system diseases associated with pain syndromes has been performed. Material and methods. System, conceptual, process and situational approaches, methods of historical, marketing, structural-functional and logical analysis were used in the study. Analysis of available native and foreign sources of literature was performed in order to achieve this goal. The search was conducted in research databases such as eLIBRARY and PubMed in order to identify publications that include terms and concepts related to the diagnosis and management of pain in patients with blood system diseases, standardization and algorithmic approaches to pain diagnosis in articles, headings or summaries. 54 sources were selected from 200 for analysis and summary. Other papers were excluded from analisys due to the lack or incompleteness of the information that satisfy the goal of the research. Results and discussion. The features of the use of valid clinically effective pain assessment questionnaires for various blood diseases associated with pain syndromes are indicated as well their weak and strong points. The advantages of strain gage analysis are described. In a number of cases it is possible to detect the presence of central sensitization, psycho-emotional components of the pain syndrome, to determine prognosis and to monitor the effectiveness of treatment. It is recommended to use ANI monitoring in patients with pain as contact with them is difficult (patients with porphyria, patients in coma or in perioperative period). Algorithms for using described diagnostic instruments in patients with diseases of the blood system associated with pain syndrome are presented. Conclusion. The use of a variety of diagnostic tools in patients with blood system diseases associated with pain will make it possible to perform differential diagnosis of pain syndrome and dynamic evaluation and it will improve the quality of pain management.

Key words: review, pain, hematology, pain diagnosis, pain scales, neuropathic pain, quality of life, strain gage analisys, ANI-monitoring.

For reference: Levchenko OK, Berseneva EA. The features of pain diagnostics in patients with blood system diseases. The Bulletin of Contemporary Clinical Medicine. 2018; 11 (3): 65–76. DOI: 10.20969/VSKM.2018.11(3).65-76.

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53. Jendoubi A, Abbes A, Ghedira S, Houissa M. Pain measurement in mechanically ventilated patients with traumatic brain injury: behavioral pain tools versus ana lgesia nociception index. Indian J Crit Care Med. 2017; 21 (9): 585-588.

54. Levchenko OK, Spirin MV, Galstyan GM, Savchenko VG, Chumachenko ED. Monitoring boli u gematologicheskih pacientov [Pain monitoring in hematological patients]. Klinicheskaya anesteziologiya i intensivnaya terapiya [Clinical anesthesiology and intensive care]. 2017; 2: 99-102.

 

 THE FEATURES OF MYOCARDIUM REPERFUSION IN SMOKERS IN ACUTE MYOCARDIAL INFARCTION ACCORDING TO MRI

УКД 616.127-005.8:613.84(048.8)

DOI: 10.20969/VSKM.2018.11(3).76-81

SHARAFEEV AYDAR Z., D. Med. Sci., Head of the Department of cardiology, endovascular and cardiovascular surgery of Kazan State Medical Academy – branch of the Russian Medical Academy of postgraduate education, Russia, 420012, Kazan, Mushtari str., 11, tel. 8-927-410-93-89, e-mail: aidarch@mail.ru

MALOV ALEXEY A., C. Med. Sci., assistant of professor of the Department of oncology with the course of radiation diagnostics and radiation therapy of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49

ALKHAZUROV ALBERT I., physician of the Department of angiographic and x-ray surgical studies of Medical Unit of Kazan Federal University, Russia, 420043, Kazan, Chekhov str., 1a, tel. 8-937-524-07-05, e-mail: a.alhazurov@mail.ru 

KHALIRAKHMANOV AIRAT F., C. Med. Sci., physician of the Department of angiographic and x-ray surgical studies of Medical Unit of Kazan Federal University, Russia, 420043, Kazan, Chekhov str., 1a, tel. 8-929-722-33-34, e-mail: ai.bolit@mail.ru

GABDULKHAKOV ELVIR F., physician of the Department of angiographic and x-ray surgical studies of Medical Unit of Kazan Federal University, Russia, 420043, Kazan, Chekhov str., 1a, tel. 8-987-067-95-42, e-mail: elvirchiky@mail.ru

Abstract. Aim. Analysis of latest publications devoted to the study of «smoker`s paradox» has been performed. Material and methods. Scientific publications devoted to the «smoker`s paradox» have been studied. Results and discussion. Smoking is the factor increasing the risk of cardiovascular diseases. However, during the last years there have been multiple studies of «smoker`s paradox» phenomenon. According to the majority of authors low mortality rate and positive outcome is observed in smokers in comparison to non-smokers. The majority of researchers studying the «smoker`s paradox» didn`t observe the interdependence between the smoking itself and clinical symptoms with correction of other risk factors (for example, age). However, some authors consider that smoking can be related to myocardial hypertrophy at one side and less myocardial damage at another side. Cardiac magnetic resonance imaging is «the golden standard» of quantifying myocardial damage in transmural myocardial infarction with ST-elevation and it is the most valuable diagnostic method of studying the «smoker`s paradox». Conclusion. Results of the latest researches lead to an important step towards the better understanding of reperfusion damage in smokers. Nowadays it can be considered only a hypothesis, but not the proof of the difference between the degree of myocardial infarction and cardiac remodelling in smokers and non-smokers. This data should stimulate new clinical research for the better understanding of the «smoker`s paradox» in myocardial infarction.

Key words: smoker`s paradox, acute coronary syndrome, myocardial infarction.

For reference: Sharafeev AZ, Malov AA, Alkhazurov AI, Khalirakhmanov AF, Gabdulkhakov EF. The features of myocardium reperfusion in smokers in acute myocardial infarction according to MRI. The Bulletin of Contemporary Clinical Medicine. 2018; 11 (3): 76–81. DOI: 10.20969/VSKM.2018.11(3).76-81. 

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 COMPARATIVE EFFECTIVENESS OF PARTICULAR TYPES OF BIOLOGICAL MATERIALS IN VARIOUS PELVIC FLOOR DEFECTS

UDC [616.62-008.222-055.2+618.14-007.44]-08(048.8)

DOI: 10.20969/VSKM.2018.11(3).82-88

YASCHUK ALFIYA G., D. Med. Sci., professor, Head of the Department of obstetrics and gynecology № 2 of Bashkir State Medical University, Russia, 450008, Ufa, Lenin str., 3

MUSIN ILNUR I., C. Med. Sci., associate professor of the Department of obstetrics and gynecology № 2 of Bashkir State Medical University, Russia, 450008, Ufa, Lenin str., 3, tel. +7-917-467-10-64, e-mail: ilnur-musin@yandex.ru

NAFTULOVICH RAISA A., C. Med. Sci., associate professor of the Department of obstetrics and gynecology № 2 of Bashkir State Medical University, Russia, 450008, Ufa, Lenin str., 3

ZAINULLINA RAISA M., C. Med. Sci., associate professor of the Department of obstetrics and gynecology № 2 of Bashkir State Medical University, Russia, 450008, Ufa, Lenin str., 3

POPOVA ELENA M., assistant of professor of the Department of obstetrics and gynecology № 2 of Bashkir State Medical University, Russia, 450008, Ufa, Lenin str., 3

MEKHTIEVA ELVIRA R., assistant of professor of the Department of obstetrics and gynecology № 2 of Bashkir State Medical University, Russia, 450008, Ufa, Lenin str., 3

SAFIULLIN RUSLAN I., D. Med. Sci., professor of the Department of urology of Bashkir State Medical University, Russia, 450008, Ufa, Lenina str., 3

ABSALYAMOVA DINA F., C. Med. Sci., Head of maternity department of Ufa Demskiy District City Cinical Hospital, Russia, 450095, Ufa, Pravda str., 19

MOLOKANOVA ANZHELLA R., student of the general medicine faculty of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49

Abstract. Stress urinary incontinence and prolapse of pelvic organs is a global problem that adversely affects the quality of life of women in different age groups. This article is an analysis of the methods of correction of these disorders in various defects of the pelvic floor. Aim. Analysis and evaluation of various biological materials used in pelvic floor inconsistency and stress urinary incontinence, such as urethral sling, biological transplants and stem cells have been performed based on the international publication data. Material and methods. The papers of multiple foreign and native authors were used for evaluation and comparison. Stem cell mechanisms of action and their comparative characteristics are considered according to the results of conducted research. The achievements in tissue engineering have been analyzed and the value of personal stem cells derived from muscle, fat, mesenchymal tissues, bone marrow and endometrium have been studied. The advantages and disadvantages of synthetic and biological materials are evaluated. Results and discussion. Despite a large number of native and foreign publications on the problem of pelvic floor inconsistency and extensive research on incontinence problem, there is currently no differentiated approach to the choice of surgical and conservative treatment methods in various pelvic floor defects that would significantly improve the results of treatment. Conclusion. A number of scientific data indicates a relatively high efficiency of using personal stem cells. At the present stage scientific research in this direction is extremely promising.

Key words: prolapse of pelvic organs, biological materials, urinary incontinence, stem cells.

For reference: Yashchuk AG, Musin II, Naftulovich RA, Zainullina RM, Popova EM, Mekhtieva ER, Safiullin RI, Absalyamova DF, Molokanova AR. Comparative effectiveness of particular types of biological materials for various pelvic floor defects. The Bulletin of Contemporary Clinical Medicine. 2018; 11 (3): 82–88. DOI: 10.20969/VSKM.2018.11(3).82-88.

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CLINICAL CASE

 A RARE CLINICAL CASE OF TOMINXOSIS

UDC 616.995.132 

DOI: 10.20969/VSKM.2018.11(3).89-91

KALINKIN ALEKSANDER L., Head of the Department of internal medicine of Shumerlinsky Interregional Medical Center, Russia, 429127, Shumerlya, Sverdlov str., 2, e-mail: aleks_kalinkin@mail.ru

MAKAROVA NADEZHDA I., Head of clinical diagnostic laboratory of Shumerlinsky Interregional Medical Center, Russia, 429127, Shumerlya, Sverdlov str., 2

CHUMEYKIN STANISLAV A., student of medical faculty of I.N. Ulyanov Chuvash State University, Russia, 428015, Cheboksary, Moskovsky ave., 15

Abstract. Tominxosis is a nematodosis-zoonosis, which manifests with severe respiratory disorders. It refers to rare human diseases. At present single publications that describe the clinical cases of the disease are available. Aim. The problem of tominxosis diagnosis in patient with concomitant pulmonary diseases was demonstrated on the example of a clinical case of tominxosis in patient with chronic obstructive pulmonary disease. Material and methods. Complex examination was carried out. The features of clinical course and provision of medical care to a man, born in 1954, with tominxosis were revealed. Results and discussion. Diagnosis and treatment of chronic obstructive pulmonary disease and emphysema complicated by tominxosis is shown on the clinical example. Having the previous test results of the patient, it can be concluded that there is no change in blood and urine biochemistry, no visible changes in lung radiography, spirography or other tests, despite the addition of a new infection to the chronic pulmonary diseases. The diagnosis of tominxosis was made by detecting Thominx aerophilus eggs in the sputum. Conclusion. Tominxosis is one of the rarely diagnosed helminthiases. This rare clinical case of tominxosis demonstrates that the diagnosis of tominxosis is very difficult in medical history of chronic obstructive pulmonary disease. Despite the rarity of human tominxosis we should not exclude helminthiases of the lungs in patients, especially with associated pulmonological profile.

Key words: treatment of tominxosis, tominxosis, tominxes.

For reference: Kalinkin AL, Makarova NI, Chumeikin SA. A rare clinical case of tominxosis. The Bulletin of Contemporary Clinical Medicine. 2018; 11 (3): 89–91. DOI: 10.20969/VSKM.2018.11(3).89-91.

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