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ORIGINAL ARTICLES
The impact of adjustment disorder on the quality of life of police officers. Shibaev P.V. P.96
REVIEWS
ORGANIZATION OF HEALTHCARE
CLINICAL CASE
THESIS RESEARCHES
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THE 95TH ANNIVERSARY OF INSTITUTIONAL HEALTHCARE OF MINISTRY OF INTERNAL AFFAIRS OF RUSSIA
UDC 614.2:351.74(470+571)(091
DOI: 10.20969/VSKM.2016.9(6).9-12
SIDORENKO VITALY A., C. Med. Sci., associate professor, deputy head of the Department on material and technical
logistics of MIA of Russia, Head of Management of medical support, major general of internal service
UDC 614.2 (470.41):351.74
DOI: 10.20969/VSKM.2016.9(6).13-15
KHISAMIYEV RUSTEM SH., GINJATULLINA LJAYSAN R., AMIROV NAIL B.
Key words: medical service, Ministry of Internal Affairs, MIA pensioners
CLINICAL FEATURES OF ISCHEMIC STROKE COMPLICATED BY NOSOCOMIAL INFECTION
UDC 616.831-005.4-06:616.24-002
DOI: 10.20969/VSKM.2016.9(6).16-20
AGAFONOV KONSTANTIN I., assistant of professor of the Department of neurology and neurosurgery of Smolensk State Medical University, Russia, 214019, Smolensk, Krupskaya str., 28, e-mail: agafonov-konstantin@ya.ru
TRIASUNOVA MARINA A., neurologist of Smolensk regional Clinical hospital, assistant of professor of the Department of neurology and neurosurgery of Smolensk State Medical University, Russia, 214019, Smolensk, Krupskaya str., 28, e-mail: tryassunowa_marina@mail.ru
ALYOSHINA ELENA N., C. Med. Sci., neurologist, deputy director of Military physician board of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Smolensk region, captain of internal service, Russia, 214000, Smolensk, Oktyabrskaya revolyutsiya str., 14, e-mail: hellen.al@mail.ru
MASLOVA NATALIA N., D. Med. Sci., professor, Head of the Department of neurology and neurosurgery of Smolensk State Medical University, Russia, 214019, Smolensk, Krupskaya str., 28, e-mail: maslovasm@yahoo.com
TIMOFEEV SERGEY I., Head of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Smolensk region, physicion, colonel of internal service, Russia, 214000, Smolensk, Oktyabrskaya revolyutsiya str., 14, e-mail: smol.timofeev@gmail.com
TAGIEVA ELNARA J., 4th year student of the faculty of clinical psychology of Smolensk State Medical University, Russia, 214019, Smolensk, Krupskaia str., 28, e-mail: tagievamagda@mail.ru
GAPONOVA VERA N., 4th year student of the faculty of clinical psychology of Smolensk State Medical University, Russia,
214019, Smolensk, Krupskaia str., 28, e-mail: verkagap@gmail.com
Abstract. Aim. Assessment of the prevalence of infectious complications in patients with acute stroke. Establishing correlations between the presence of pneumonia and rehabilitation prognosis. Material and methods.132 hospitalized to Regional Vascular Centre of Smolensk Regional Clinical hospital patient cases were analyzed. Statistical analysis of mortality, incidence of pneumonia (clinical and x-ray features) and number of clinical pharmacologist consultation was performed. Biochemical indicators of nutritional status were also analyzed. Results and discussion. Significant correlations between hypoproteinemia, mobility disorders (according to Rankin scale, Rivermead mobility index and NIHSS) and infectious complications incidence was established (p≤0,05; rs=0,85). These complicated conditions in patients with stroke increase the duration of hospital treatment (for more than 10 days) and worsen recovery prognosis (significant correlation with mortality, p≤0,01, rs=0,67). Conclusion. Hospital patients with severe and moderate mobility disorders (4 points according to Rankin scale) require significant prevention measures for infectious complications. This group of patients needs additional nutritional support to decrease risk of infectious complications and mortality rates.
Key words: stroke, dysphagia, nosocomial infections, pneumonia.
For reference: Agafonov KI, Triasunova MA, Alioshina EN, Maslova NN, Timofeev SI, Tagieva ED, Gaponova VN. Clinical features of ischemic stroke complicated by nosocomial infection. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 16—20.
References
1. Martynov JuS, Kevdina ON, Shuvahina NA et al. Pnevmonija pri insul’te [Pneumonia in stroke]. Nevrologicheskij zhurn [Neurological journal]. 1998; 3: 18-21.
2. Vilenskij BS. Oslozhnenija insul’ta: profilaktika i lechenie [Stroke complications: prevention and treatment]. SPb: Foliant. 2000; 77-79.
3. Davenport R еt al. Complications following acute stroke. Stroke. 1996; 27: 415-420.
4. Kalra K et al. Medical complications during stroke rehabilitation. Stroke. 1995; 26: 990-994.
5. Ragimov BC, Musaev ShM, Gasanov AB. Patomorfologicheskie izmenenija v ljogkih u bol’nyh s tjazhjolymi cherepno-mozgovymi travmami [Pathomorphological features in lungs in patients with severe brain injury]. Anesteziologija i reanimatologija [Anesthesiology and Intensive Care]. 2007; 1: 57-60.
6. Rakov AL, Panfilov DN, Gel’cer BI. Mestnyj kletochnyj i gumoral’nyj immunitet u bol’nyh pnevmoniej [Local cell and humoral immunity in patients with pneumonia]. Klinicheskaya medicina [Clinical medicine]. 2000; 10: 32-36.
7. Ershov AL. Etiologicheskie i patogeneticheskie osobennosti nozokomial’noj pnevmonii, svjazannoj s IVL (NPivl) [Ethiological and pathogenetic features of nosocomial pneumonia related to artificial ventilation]. Anesteziologija i reanimatologija [Anesthesiology and Intensive Care]. 2000; 3: 69-73
8. Jakovlev CB. Sovremennye problemy antibakterial’noj terapii gospital’nyh infekcij: «gorjachie tochki» rezistentnosti [Nowadays problems of nosocomial infections treatment: «hot points» of resistance]. Medicinskie novosti [Medical news]. 2005; 3: 37-43.
9. De Pippo KL et al. Dysphagia therapy following stroke: a controlled tril. Neurology. 1994; 44: 1655-1660.
10. Kondrat’ev AN, Ivchenko IM. Anestezija i intensivnaja terapija travmy central’noj nervnoj sistemy [Anestesiology and intensive care of central nervous system injuries]. SPb: Medicinskoe izdatelstvo [SPb: Medical Publishing House]. 2002; 128 p.
ISSUES OF SURGICAL TREATMENT OF LIVER CIRRHOTIC PATIENTS WITH VARICEAL ESOPHAGOGASTRIC BLEEDING
UDC [616.36-004-06:616.329/.33-005.1]-089
DOI: 10.20969/VSKM.2016.9(6).20-27
ANISIMOV ANDREY YU., D. Med. Sci., professor, Head of the Department of еmergency medical care of Kazan State Medical Academy, Chief visiting surgeon of the Ministry of Health of Tatarstan Republic, Russia, 420012, Kazan, Mushtari str., 11, tel. +7-987-297-16-54, e-mail: aanisimovbsmp@yandex.ru
MAMKEEV ELDAR KH., C. Med. Sci., associate professor of the Department of epidemiology and disinfectology of Kazan State Medical Academy, Russia, 420012, Kazan, Mushtari str., 11
AMIROV NAIL B., D. Med. Sci., professor of the Department of general medical practice of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, e-mail: namirov@mail.ru
LOGINOV ALEXANDER V., surgeon of the Department of emergency of Clinical hospital № 7, Russia, 420103, Kazan, Chuikov str., 54
KUZNETSOV MAKSIM V., C. Med. Sci., deputy head physician of Clinic of Medical University, Russia, 420012, Kazan, Tolstoy str., 4
ANISIMOV ANDREY A., pediatric faculty student of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49
Abstract. Aim. To improve the results of surgical treatment in patients with liver cirrhosis complicated by bleeding from varicose esophagus and stomach veins using invasive approach. Material and methods. Analysis of the results of treatment of 105 patients with liver cirrhosis with intrahepatic portal hypertension syndrome for the period 2006—2014 was performed. The 1st investigated group consisted of 77 patients with liver cirrhosis complicated by variceal esophagogastric bleeding. They underwent conservative treatment using surgical methods only as «the operation of despair». The 2nd investigated group consisted of 28 patients, whose treatment program included an active surgical approach using M.D. Patsiora surgery. Endoscopic haemostatic self-expanding nitinol Danish stent was placed in 17 patients with portal hypertension with the high risk of rebleeding instead of traditional Sengstaken-Blackmore balloon tamponade. Results and discussion. Conservative treatment does not allow avoiding a large number of complications and significantly reduces mortality rates in patients with liver cirrhosis complicated by esophagogastric bleeding. Surgical approach can reduce the total number of complications from 97,4 to 25,0%, including bleeding relapse — from 12,9 to 7,1%, liver failure — from 16,9 to 14,3%, the median festering wounds — from 6,5 to 3,6%, pneumonia and pleurisy — from 2,3 to 0%, postoperative mortality from 100 to 35,7%, hospital mortality from 76,6 to 35,7%, the time of hospital treatment of patients in class A (18,1±3,0) to (13,0±2,0) days, in class B (22,0±2,0) to (17,25±1,0) days. Conclusion. Invasive approach using M.D. Patsiora surgery helps to achieve sustainable remission of gastroesophageal bleeding as the main symptom of the disease.
Key words: portal hypertension, liver cirrhosis, variceal esophogastrical bleeding, endoscopic hemostasis, surgical treatment.
For reference: Anisimov AY, Mamkeev EH, Amirov NB, Loginov AV, Kuznetsov MV, Anisimov AA. Issues of surgical treatment of liver cirrhotic patients with variceal esophagogastric bleeding. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 20—27.
References
1. Kitsenko EA, Anisimov AY, Andreev AI. Sovremennoe sostoyanie problemi krovotechenii iz varikozno rasshirennih ven pishevoda I zheludka [The modern state of bleeding from variceal enlarged veins of esophagus and stomach]. Vestnik sovremennoy klinicheskoy meditsiny [The Bulletin of Contemporary Clinical Medicine]. 2014; 7 (5): 89–98.
2. Fortune B, Garcia–Tsao G. Current Management Strategies for Acute Esophageal Variceal Hemorrhage. Curr Hepatol Rep. 2014; 13 (1): 35–42.
3. Reverter E, Tandon P, Augustin S, Turon F, Casu S, Bastiampillai R, Keough A, Llop E, González A, Seijo S, Berzigotti A, Ma M, Genescà J, Bosch J, García–Pagán JC, Abraldes JG. A MELD–based model to determine risk of mortality among patients with acute variceal bleeding. Gastroenterology. 2014; 146 (2): 412–419.
4. De Franchis R. Revising consensus in portal hypertension: report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol. 2010; 53: 762–768.
5. Wang C, Xiao L, Han J, Jin CE, Peng Y, Yang Z. A prospective randomized trial of selective versus nonselective esophagogastric devascularization for portal hypertension. J Huazhong Univ Sci Technolog Med Sci. 2014; 34 (4): 563–568.
6. Shertsinger AG, Zhao AV, Ivashkin VT et al. Lechenie krovotecheniy iz varikozno rasshirennih ven pishevoda I zheludka [Treatment of bleedings from varicose veins of the esophagus and stomach]. Annaly khirurgicheskoy gepatologii [Annals of surgical hepatology]. 2013; 18 (3): 110–129.
7. Anisimov AY, Vertkin AL, Devyatov AV et al. Practicheskie recommendacii po lecheniyu krovotecheniy iz varikozno rasshirennih ven pishevoda I zheludka [Practical recommendations for the treatment of esophageal and gastric varices bleeding]. Moskovskiy khirurgicheskiy zhurnal [Moscow surgical journal]. 2013; 6: 41–54.
8. Anisimov AY. Surgical Treatment of Patients with Hepatic Cirrhosis Accompanied by Esophageal and Gastric Variceal Hemorrhage. International Journal Of Pharmacy & Technology. 2016; 8 (2): 13636–13646.
9. Kumar S, Asrani SK, Kamath PS. Epidemiology, diagnosis and early patient management of esophagogastric hemorrhage. Gastroenterol Clin North Am. 2014; 43 (4): 765–782.
10. Anisimov AY. Sovershenstvovanie diagnostiki I khirurgicheskogo lecheniya bolnih s portalnoy hypertensiey [Improvement of the diagnosis and surgical treatment of patients with portal hypertension]. Annaly khirurgicheskoy gepatologii [Annals of surgical hepatology]. 2015; 20 (2): 59–65.
11. Cárdenas A, Baiges A, Hernandez–Gea V, Garcia–Pagan JC. Endoscopic hemostasis in acute esophageal variceal bleeding. Gastroenterol Clin North Am. 2014; 43 (4): 795–806.
12. Azam Z, Hamid S, Jafri W, Salih M, Abbas Z, Abid S, Shah H. Short course adjuvant terlipressin in acute variceal bleeding: a randomizeddouble blind dummy controlled trial. J Hepatol. 2012; 56 (4): 819–824.
13. Zhao JR, Wang GC, Hu JH, Zhang CQ. Risk factors for early rebleeding and mortality in acute variceal hemorrhage. World J Gastroenterol. 2014; 20 (47): 17941–17948.
14. Orloff MJ, Isenberg JI, Wheeler HO, Haynes KS, Jinich–Brook H, Rapier R, Vaida F, Hye RJ. Emergency portacaval shunt versus rescue portacaval shunt in a randomized controlled trial of emergency treatment of acutely bleeding esophageal varices in cirrhosis–part 3. J Gastrointest Surg. 2010; 14 (11): 1782–1795.
15. Coelho FF, Perini MV, Kruger JA, Fonseca GM, Araújo RL, Makdissi FF, Lupinacci RM, Herman P. Management of variceal hemorrhage: current concepts. Arq Bras Cir Dig. 2014; 27 (2): 138–144.
16. Qi X, Jia J, Bai M, Guo X, Su C, García–Pagán JC, Han G, Fan D. Transjugular Intrahepatic Portosystemic Shunt for Acute Variceal Bleeding: A Meta–analysis. J Gastroenterol. 2013; 48: 771-784.
17. Orloff MJ, Isenberg JI, Wheeler HO, Haynes KS, Jinich–Brook H, Rapier R, Vaida F, Hye RJ, Orloff SL. Liver transplantation in a randomized controlled trial of emergency treatment of acutely bleeding esophageal varices in cirrhosis . Transplant Proc. 2010; 42 (10): 4101–4108.
18. Eramishantsev AK, Shertsinger AG, Kitsenko EA. Portal’naya gipertenziya: klinicheskaya khirurgiya: natsional’noe rukovodstvo [Portal hypertension: clinical surgery: national guidelines]. Moskva [Moscow]: GEOTAR–Media. 2008; 626–665.
UDC 616.321/.322-002-057.36(470.53)
DOI: 10.20969/VSKM.2016.9(6).27-33
BABUSHKIN SERGEY A., Chief of Sanitary-Epidemiological department of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Perm region, Russia, 614000, Perm, Permskaya str., 128, e-mail: permguvdcgsn@mail.ru
IVENSKIKH VIKTOR I., Chief of Sanitary-Epidemiological department of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Perm region, Russia, 614000, Perm, Permskaya str., 128, e-mail: permguvdcgsn@mail.ru
MAMAEV ALEXEY V., deputy chief of Sanitary-Epidemiological department of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Perm region, Russia, 614000, Perm, Permskaya str., 128, e-mail: permguvdcgsn@mail.ru
OZHGIBESOV GEORGY P., chief of the laboratory of bacteriological of Sanitary-Epidemiological department of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Perm region, Russia, 614000, Perm, Permskaya str., 128, e-mail: medmicrobiolog@gmail.com
NIKULINA ELENA A., bacteriologist of Sanitary-Epidemiological department of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Perm region, Russia, 614000, Perm, Permskaya str., 128, e-mail: medmicrobiolog@gmail.com
SHUBINA NADEZHDA V., epidemiologist of Sanitary-Epidemiological department of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Perm region, Russia, 614000, Perm, Permskaya str., 128, e-mail: permguvdcgsn@mail.ru
GODOVALOV ANATOLIY P., C. Med. Sci., bacteriologist of Sanitary-Epidemiological department of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Perm region, Russia, 614000, Perm, Permskaya str., 128, e-mail: AGodovalov@gmail.com
Abstract. Aim. Analysis of characteristics of acute pharyngitis and tonsillitis morbidity among the employees of the Ministry of internal affairs of Russia in the Perm region, as well as the study of the spectrum of pathogens. Material and methods. The study of the epidemic process of acute pharyngitis and tonsillitis manifestations was based on a detailed retrospective analysis of the incidence among employees of the Ministry of internal affairs of Russia in Perm region for the period from 2003 to 2013. Microbiological study of the upper respiratory tract secretion was performed on 841 patient. Results and discussion. The incidence of acute pharyngitis and tonsillitis is a topical issue. The incidence of acute pharyngitis and tonsillitis in law enforcement officers is influenced by the complex and constant cyclic factors and by the impact of irregular accidental causes. Microbiological examination of the upper respiratory tract secretion has showed that pathological process is usually caused by association of several microorganisms. Significant etiologic agents are group A streptococci and yeast-like Candida fungi. Conclusions. The study showed remarkable reduction in the incidence of acute pharyngitis and tonsillitis, including pathogens leading position occupied by gram-positive cocci, and in particular members of the genus Streptococcus, among employees of the Ministry of internal affairs of Russia in the Perm region. Reduction of the incidence is a result of sustained and continuous activity of the sanitary and anti-epidemiological service, affecting all the parts of the epidemic process.
Key words: long-term dynamics of morbidity, pharyngitis, tonsillitis, acute respiratory infections, Streptococcus spp.
For reference: Babushkin SA, Ivenskih VI, Mamaev AV, Ozhgibesov GP, Nikulina EA, Shubina NV, Godovalov AP. Epidemiological and microbiological aspects of the incidence of acute pharyngitis and tonsillitis among employees of the Ministry on internal affairs of Russia in the Perm region. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 27—33.
References
1. Kazakovcev VP. Zabolevaemost’ naselenija krupnogo promyshlennogo centra boleznjami verhnih dyhatel’nyh putej [Morbidity of the upper respiratory tract disease among people from large industrial center]. Omskij nauchnyj vestnik [Omsk Scientific Bulletin]. 2014; 134: 45-47.
2. Bant’eva MN, Prilipko NS. Vozrastnye aspekty zabolevaemosti vzroslogo naselenija po obrashhaemosti v ambulatorno-poliklinicheskie uchrezhdenija [Age-related aspects of adult morbidity for negotiability in out-patient clinics]. Social’nye aspekty zdorov’ja naselenija [Social aspects of public health]. 2013; 4: 32.
3. Shpynev KV, Krechikov VA. Sovremennye podhody k diagnostike streptokokkovogo faringita [Modern approaches to the diagnosis of streptococcal pharyngitis]. KMAH [Clinical Microbiology and Antimicrobial Chemotherapy]. 2007; 9 (1): 20–33.
4. Luchsheva JuV, Izotova GN. Mestnaja terapija pri faringite [Local therapy for pharyngitis]. RMZh [Russian Medical Journal]. 2011; 19 (6): 25-28.
5. Beljakov VD, Semenenko TA, Shraga MH. Vvedenie v jepidemiologiju infekcionnyh i neinfekcionnyh zabolevanij cheloveka [Introduction to the epidemiology of infectious and non-infectious human diseases]. M: Medicina [Medicine]. 2001; 264 p.
6. Sepetliev DM. Statisticheskie metody v nauchnyh medicinskih issledovanijah [Statistical methods in medical research]. M: Medicina [Medicine]. 1968; 298 p.Bessen DE. Tissue tropisms in group A Streptococcus: what virulence factors distinguish pharyngitis from impetigo strains? Curr Opin Infect Dis. 2016; 29 (3): 295-303.
8. Chauhan S, Kashyap N, Kanga A, Thakur K, Sood A, Chandel L. Genetic Diversity among Group A Streptococcus Isolated from Throats of Healthy and Symptomatic Children. J Trop Pediatr. 2016; 62 (2): 152-157.
9. Kumar R, Vohra H, Chakraborty A, Sharma YP, Bandhopadhya S, Dhanda V, Sagar V, Sharma M, Shah B, Ganguly NK. Epidemiology of Group A streptococcal pharyngitis & impetigo: a cross sectional and follow up study in a rural community of northern India. Indian J Med Res. 2009; 130: 765–771.
10. Ozturk CE, Yavuz T, Kaya D, Yucel M. The rate of asymptomatic throat carriage of Group A streptococcus in school children & associated ASO titres in Duzce, Turkey. Jpn J Infect Dis. 2004; 57: 271–272.
11. Aracil B, Miñambres M, Oteo J, Torres C, Gómez-Garcés JL, Alós JI. High prevalence of erythromycin-resistant and clindamycin-susceptible (M phenotype) viridans group streptococci from pharyngeal samples: a reservoir of mef genes in commensal bacteria. J Antimicrob Chemother. 2001; 48 (4): 592-594.
12. Godovalov AP, Bykova LP, Ozhgibesov GP. Znachenie gribov roda Candida pri vospalitel’nyh zabolevanijah dyhatel’nyh putej [Meaning of fungi of the genus Candida in inflammatory diseases of the airways]. Sibirskij medicinskij zhurnal (Irkutsk) [Siberian Medical Journal (Irkutsk)]. 2008; 82 (7): 10-12.
13. Luna VA, Coates P, Eady EA, Cove JH, Nguyen TTH, Roberts MC. A variety of Gram-positive bacteria carry mobile mef genes. J Antimicrob Chemother. 1999; 44: 19–25.
14. Kim PE, Musher DM, Clezen WP, Rodriguez-Barradas MC, Nahm WK, Wright CE. Association of invasive pneumococcal disease with season, atmospheric conditions, air pollution, and the isolation of respiratory viruses. Clin Infect Dis. 1996; 22: 100–106.
15. Alonso JM, Guiyoule A, Zarantonelli ML, Ramisse F, Pires R, Antignac A, Deghmane AE, Huerre M, van der Werf S, Taha MK. A model of meningococcal bacteremia after respiratory superinfection in Influenza A virus infected mice. FEMS Microbiol Lett. 2003; 222: 99–106.
16. Lowy FD. Staphylococcus aureus infections. N Engl J Med. 1998; 339: 520–532.
17. Kluytmans JA, Wertheim HF. Nasal carriage of Staphylococcus aureus and prevention of nosocomial infections. Infections. 2005; 33: 3–8.
18. Gowrishankar S, Thenmozhi R, Balaji K, Pandian SK. Emergence of methicillin-resistant, vancomycin-intermediate Staphylococcus aureus among patients associated with group A Streptococcal pharyngitis infection in southern India. Infect Genet Evol. 2013; 14: 383-389.
UDC 617.586:616.5-002.44-009.85-089.844
DOI: 10.20969/VSKM.2016.9(6).33-38
VALEEV MARAT M., D. Med. Sci., professor of the Department of traumatology and orthopedics of Bashkir State Medical University, Russia, 450000, Ufa, Lenin str., 3, tel. 8-917-463-80-90, e-mail: valeevmm@rambler.ru
BIKTASHEVA ELINA M., postgraduate student of the Department of traumatology and orthopedics of Bashkir State Medical University, Russia, 450000, Ufa, Lenin str., 3
KHALIKOV RUSTAM A., Head of the Department of dispensary № 2 of Hospital of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Republic of Bashkortostan, Russia, 450015, Ufa, K. Marx str., 59
KHALIKOVA LEYSAN N., transfusiologist of the Department of blood transfusion unit of G.G. Kuvatov Republic Clinical Hospital, Russia, 450005, Ufa, Dostoevsky str., 132
NIGMATULLIN RUSTEM KH., C. Med. Sci., deputy head of Medical Care unit of the Ministry of Internal Affairs of Russia in the Republic of Bashkortostan, Russia, 450015, Ufa, K. Marx str., 59, tel. 8-917-773-81-92, e-mail: nigrustem@yandex.ru
Abstract. Aim. Improvement of results of surgical treatment and postoperative management of patients with neurotrophic ulcers of the load zone of calcaneal region of the foot based on composite perfused skin flaps. Material and methods. Long-term results of surgical treatment of 37 patients with neurotrophic ulcers of the pressed zone of the foot calcaneal area using compound vascularized flaps were presented. All patients had a history of spinal injuries: falls from height, road accident or mine blast injuries. Results and discussion. Assessment of quality of life of the patients treated showed that depression level before and after surgery decreased from 36,5 to 26,5 scores, trait anxiety level — from 45,8 to 19 as well as the rates of general health, physical, role, social and emotional functioning. Auto transplantation turned out to be successful. A five-year follow-up period showed that three patients had flap ulcerations and two — clavus in cicatrix area. Conclusion. Proposed integrated approach using vascularised complex set of patches is optimal. It significantly improves the quality of life of patients with neurotrophic ulcer of the supporting area of calcaneal region of the foot.
Key words: neurotrophic ulcer, foot, calcaneal area, skin grafting, compound flaps, plastic surgery, microsurgery.
For reference: Valeyev MM, Biktasheva EM, Khalikov RA, Khalikovа LN, Nigmatullin RCh. Surgical treatment and postoperative management of patients with neurotrophic ulcers of the pressed zone of the foot calcaneal region using compound flaps. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 33—38.
References
1. Minasov BSh, Valeev ММ, Valeeva EM. Sposob rotacii medial’nogo kozhno–fascial’nogo loskuta stopy pri plastike myagkih tkanej stopy: Patent № 2357696 [The rotation of the medial skin and fascial flap of the foot for plastic soft tissues of the foot: Patent 2357696]. Oficial’nyj byulleten’ Federal’noj sluzhby po in–tellektual’noj sobstvennosti, patentam i tovarnym znakam [Official Bulletin of the Federal Service for Intellectual Property, Patents and Trademarks]. 2009; 19.
2. Schwartz R, Negrini JF. Medial plantar artery island flap for heel reconstruction. Ann Plast Surg. 2006; 57 (6): 658–661.
3. SHihaleva NG, Ivanov GP, Gohaeva AN, Dolganova TI. Rezul’tat hirurgicheskogo lecheniya nejrotroficheskoj yazvy pyatochnoj oblas–ti, osnovannogo na sochetanii chreskostnogo osteosintez i mikrohirurgiche–skih tekhnologij [The result of surgical treatment of neurotrophic ulcers of the heel region, based on a combination of external fixation and microsurgical technologies]. Genij ortopedii [Genius orthopedics]. 2011; 3: 42–46.
4. Obolenskij VN, Rodoman GV, Nikitin SP. Troficheskie yazvy nizhnih konechnostej — obzor literatury [Trophic ulcers of the lower limbs — a review of the literature]. Russkij medicinskij zhurnal [Russian medical journal]. 2009; 17 (25): 1647–1662.
5. Baker GL, Newton ED, Franklin MD. Fasciocutaneous island flap based on the medial plantar artery: clinical applications for leg, ankle and forefoot. Plast Reconstr Surg. 1990; 85: 47.
6. Goldberg JA, Adkins P, Tsai TM. Microvascular reconstruction of the foot: weight bearing patterns, gait analysis, and long term follow–up. Plast Reconstr Surg. 1993; 92: 904.
7. Kutyapov DI, Rodomonova LA. Sovremennye principy i tendencii ispol’zovaniya osevyh krovosnabzhaemyh loskutov v rekonstruktivnoj hi–rurgii konechnostej [Modern principles and trends in the use of the axial perfused flaps in reconstructive surgery of extremities]. Travmatologiya i ortopediya Rossii [Traumatology and orthopedics Russia]. 2015; 1: 106–115.
8. Minasov BSh, Valeev MМ, Biktasheva EhM. Taktika hirurgicheskogo lecheniya i posleoperacionnogo vedeniya pacientov s nejrotroficheskimi yaz–vami zadnego otdela stopy na osnove funkcional’nyh loskutov [Surgical treatment and postoperative management of patients with neurotrophic ulcers rearfoot on the basis of functional grafts]. Genij ortopedii [Genius orthopedics]. 2016; 3: 58–62.
9. Agris J, Spira М. Pressure ulcers: prevention and treatment. Clin Symp. 1979; 31 (5): 2–14.
10. Kochish AYU, Rodomanova LA. Vozmozhnosti zameshcheniya ranevyh defek–tov stop loskutami s osevym tipom krovosnabzheniya [Substitution Opportunities of wound defects stop flaps with axial type of blood supply]. Travmatologiya i ortopediya Rossii [Traumatology and orthopedics Russia]. 2008; 2: 120–121.
11. Borzyh AV, Trufanov IM, Pogorilyak AI, Varin VV. Kompleksnoe rekonstruktivno–vosstanovitel’noe lechenie obshirnyh posttravmaticheskih defektov goleni i stopy [Complex reconstructive treatment of extensive post–traumatic defects of the leg and foot]. Travma [Trauma]. 2009; 1: 45–52.
12. Biktasheva EhM, Minasov BSh, Valeev ММ. Mikrohirurgicheskie tekh–nologii pri lechenii bol’nyh s obshirnymi defektami myagkih tkanej pro–ksimal’nyh otdelov stopy [Microsurgical technologies in the treatment of patients with extensive soft tissue defects of the proximal foot]. Prakticheskaya medicina [Practical medicine]. 2015; 6 (91): 90–93.
13. Pahomov IA, Rerih VV, Borzyh KO. Diagnostika i lechenie sochetannyh povrezhdenij pozvonochnika i stop [Diagnosis and treatment of combined lesions of the spine and feet]. Hirurgiya pozvo–nochnika [Surgery spine]. 2008; 1: 8–13.
14. Tihilov RM, Kochish AYu, Rodomanova LA, Kutyanov DI. Vozmozhnosti sovremennyh metodov rekonstruktivno–plasticheskoj hirurgii v lechenii bol’nyh s obshirnymi posttravmaticheskimi defektami tkanej konechnostej [The Possibilities of modern methods of reconstructive plastic surgery in the treatment of patients with extensive post–traumatic tissue defects of limbs]. Travmatologiya i ortopediya Rossii [Traumatology and orthopedics Russia]. 2011; 2: 164–170.
15. Shaw WW, Hidalgo DA. Anatomic basis of plantar flap design: clinical applications. Plast Reconstr Surg. 1986; 78: 637.
CHARACTERISTICS AND PREDICTORS OF SLEEP DISTURBANCES IN LAW-ENFORCEMENT OFFICERS
UDC 616.8-009.836-057.36(571.56)
DOI: 10.20969/VSKM.2016.9(6).39-43
GOLOKOV VLADISLAV A., C. Med. Sci., internal services major, Head of the Department of neurology of the Medical Care unit of the Ministry of Internal Affairs of Russia in Yakutia region, Russia, 677005, Yakutsk, Sverdlov str., 1/2, e-mail: yamchik@inbox.ru
SHNAYDER NATALIA A., D. Med. Sci., professor, Head of the Department of medical genetics and clinical neurophysiology of V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Russia, 660022, Krasnoyarsk, Partisan Zheleznyak str., 1, e-mail:naschnaider@yandex.ru
NIKOLAEVA TATJANA YA., D. Med. Sci., professor, Head of the Department of neurology and psychiatry of M.K. Ammosov Nord-East Federal University, Russia, 677000, Yakutsk, Petr Alekseev str., 83а, e-mail: tyanic@mail.ru
DOLINSKAYA ELVIRA A., colonel of internal service, Head of the Medical Care unit of the Ministry of Internal Affairs of Russia in Yakutia region, Russia, 677005, Yakutsk, Sverdlov str., 1/2, e-mail: mshmvdrsy@mail.ru
SOLOVYEVA SARDANA F., lieutenant colonel of internal service, Head of the Hospital of the Medical Care unit of the Ministry of Internal Affairs of Russia in Yakutia region, Russia, 677005, Yakutsk, Sverdlov str., 1/2, e-mail: mshmvdrsy@mail.ru
GOLOKOVA ELENA A., neurologist of the Department of functional diagnostics of Republic Hospital № 2, Russia, 677005, Yakutsk, Petr Alekseev str., 83а, e-mail: ele-stars@mail.ru
KANTIMIROVA ELENA A., C. Med. Sci., assistant of professor of the Department of medical genetics and clinical neurophysiology of V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Russia, 660022, Krasnoyarsk, Partisan Zheleznyak str., 1, e-mail: kantilea@mail.ru
Abstract. Aim. Assessment of sleep disturbances in law-enforcement officers. Material and methods. 120 Internal Affairs service employees were examined. All patients have taken sleep-screening questionnaire including information on the lifestyle and occupation, complaints, health risks, related illnesses and assessment according to Epworth Sleepiness Scale. Results and discussion. The analysis of the results showed that the most prevalent predictors of sleep disturbances in police officers are tea and coffee consumption and smoking without statistically significant gender differences. Men compared to women significantly more often state mixed schedule, 1st degree obesity, complaints on snoring as well as they indicate longer duration and frequency of daytime sleep in a week, while women present significantly higher figures of the total duration of awakenings during the night sleep and the average amount of time required to sleep. Conclusion. The prevalence of major significant risk factors in men may cause a more pronounced negative effect on the function of sleep.
Key words: sleep disturbances, predictors, police staff, Epworth Sleepiness Scale.
For reference: Golokov VA, Shnayder NA, Nikolaeva TY, Dolinskaya EA, Solovyeva SF, Golokova EA, Kantimirova EA. Characteristics and predictors of sleep disturbances in law-enforcement officers. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 39—43.
References
1. Levin JaI. Insomnija v nevrologicheskoj praktike [Insomnia in neurological practice]. Spravochnik poliklinicheskogo vracha [Directory of outpatient physician]. 2006; 5: 49–53.
2. Polujektov MG, Levin JaI. Rasstrojstva sna i ih lechenie [Sleep disorders and their treatment]. Zhurnal nevrologii i psihiatrii imeni SS Korsakova [The Korsakov’s Journal of Neurology and Psychiatry]. 2010; 9: 70–75.
3. Newman AB, Nieto FJ, Guidry U. Relationship of sleep–disordered breathing to cardiovascular risk factors. The Sleep Heart Health Study. Am J Epidemiol. 2001; 154: 50–59.
4. Roth T. Insomnia: definition, prevalence, etiology, and consequences. Movement J Clin Sleep Med. 2007; 3 (5): 7–10.
5. Daley M. The economic burden of insomnia: direct and indirect costs for individuals with insomnia syndrome, insomnia symptoms, and good sleepers. Sleep. 2009; 32 (1): 55–64.
6. Babak SL, Golubev LA, Gorbunova MV. Dyhatel’nye rasstrojstva i narushenija sna: prakticheskoe rukovodstvo [Respiratory disorders and sleep disorders: a practical guidance]. Moskva: Izdatel’skij holding «Atmosfera» [Moscow: Publishing holding «Atmosfera»]. 2010; 168 p.
7. Koval’zon VM. Osnovy somnologii: fiziologija i nejrohimija cikla «bodrstvovanie — son», 3–e izdanie [Basics somnology physiology and neurochemistry of the cycle «wakefulness — sleep»? 3 part]. M: BINOM, Laboratorija znanij [M: BINOM, Knowledge Lab]. 2014; 239 p.
8. Kallistov DJu, Romanova EA, Gavrilova ES, Romanov AI. Narushenija dyhanija vo vremja sna u bol’nyh serdechno–sosudistymi zabolevanijami na jetape reabilitacii [Respiratory disorders during sleep in patients with cardiovascular disease at the stage of rehabilitation]. Klinicheskaja medicina [Сlinical medicine]. 2014; 92 (5): 54–57.
9. Shnayder NA, Demko IA, Alekseeva OI, Petrova MM, Kantimirova EA, Strockaja IG, Djuzhakov SK. Fenotipicheskie i genotipicheskie faktory riska sindroma obstruktivnogo apnoje / gipopnoje sna [Phenotypic and genotypic risk factors for obstructive sleep apnea / hypopnea]. Problemy zhenskogo zdorov’ja [Women’s Health Issues]. 2015; 10 (2): 55–64.
10. Golenkov AV, Kurakina NG, Prokop’eva EA, Golishnikova LI. Narushenie sna u sotrudnikov organov vnutrennih del [Sleep disturbance employees of internal affairs]. Medicinskij vestnik MVD [Medical Bulletin of MIA]. 2014; 2 (69): 68–71.
11. Greubel J, Kecklund G. The impact of organizational changes on work stress, sleep, recovery and health. Ind. Health. 2011; 43 (9): 353–364.
12. Golokov VA. Psihovegetativnye narushenija u veteranov boevyh dejstvij: kliniko–jelektrojencefalograficheskaja harakteristika i lechenie: avtoreferat dissertacii kandidata medicinskih nauk [Psychovegetative disorder in combat veterans: clinical and electroencephalographic characteristics and treatment: auto–abstract of the candidate of medical sciences]. Krasnojarsk. 2013; 24 p.
13. Polujektov MG, Levin JaI. Narushenija sna v obshhej medicinskoj praktike [Sleep disorders in common medical practice]. Doktor RU [Doctor RU]. 2012; 5 (73): 34–39.
14. Kalinkin AL. Kardiovaskuljarnye oslozhnenija i prognosticheskoe znachenie obstruktivnogo apnoje sna [Cardiovascular complications and prognostic significance of obstructive sleep apnea]. Doktor RU [Doctor RU]. 2014; 2 (90): 72–75.
PSYCHOSOCIAL ADAPTATION OF POLICE OFFICERS WITH A HISTORY OF BORDERLINE MENTAL DISORDERS
UDC 616.89-057.36(470.342)
DOI: 10.20969/VSKM.2016.9(6).43-47
ZLOKAZOVA MARINA V., D. Med. Sci., professor, Head of the Department of psychiatry and addiction medicine of V.A. Bagaev Kirov State Medical Academy, Russia, 610998, Kirov, K. Marx str., 112
ICHETOVKINA ELENA G., C. Med. Sci., Head of the Centre of psychophysiological diagnostics of the Medical Care unit of the Ministry of Internal Affairs, lieutenant colonel of internal service, Russia, 610000, Kirov, Talitsa, Prokhladnaya str., 6в, e-mail: elena.ichitovckina@yandex.ru
EPSHTEIN ANDREY M., C. Med. Sci., Honored doctor of the Russian Federation, Head of the Medical Care unit of the Ministry of Internal Affairs, retired colonel of internal service, Russia, 610000, Kirov, Talitsa, Prokhladnaya str., 6в, e-mail: ame1957@yandex.ru
Abstract. Aim. To analyze psychosocial adaptation of police combatants with transient affective reactions and borderline mental disorders four years after the execution of operational tasks in particular conditions. Material and methods. 954 police officers of the Ministry of internal Affairs were surveyed across the Kirov region. The officers were divided into three groups according to the level of mental health: I gr. — 338 healthy employees; II gr. — 311 people who had shown transient affective behavioral reactions (educational staff); III gr. — 305 people with a history of borderline mental disorders treated in a period between the travel orders. The protocols of psycho physiological examination of police officers were analyzed in dynamics (after a travel order and in four years). Results and discussion. The results of the follow-up study showed that social adaptation of ex-combatants, police officers treated for the border psychic disorders in history in majority of cases are positive. Successful maintenance of the service with a low number of disciplinary violations, more stable family relationships and low risk of destructive aggressive actions was seen. The combatants with a history of educational staff not receiving care timely present with a lower level of social adaptation, combatant accentuation are being formed. Conclusion. Creation of fundamentally new diagnostic and treatment structure in mental health centers on the basis of existing centers of psycho physiological diagnostics at Medical units of the Ministry of internal Affairs in the regions of the Russian Federation is required in order to improve the quality of medico-psychological support of combatants.
Key words: combatants, rehabilitation, borderline mental disorders, transient affective-behavioral responses.
For reference: Zlokazova MV, Ichetovkina EG, Epstein AM. Psychosocial adaptation of police officers with a history of borderline mental disorders. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 43—47.
References
1. Ichitovkina EG, Zlokazova МV, Soloviev AG. Vlijanie lichnostnyh i psihosocial’nyh harakteristik na razvitie pogranichnyh psihicheskih rasstrojstv u kombatantov ministerstva vnutrennih del [Effects of personal and psychosocial characteristics on a progress of borderline mental disorders in combatants of the Ministry of Internal Affairs]. Vestnik psikhoterapii [The Bulletin of Psychotherapy]. 2011; 37 (42): 56–68.
2. Myagkikh NI, Krylova NI. Teorija i praktika psihologii krizisnyh situacij [Theory and practice of psychology crisis]. Meditsinskii vestnik MVD [Medical messenger of the Ministry of Internal Affairs]. 2010; 5: 5–8.
3. Permogorskaya EМ, Padun MA. Posttravmaticheskij stress i semejnye otnoshenija u sotrudnikov OVD — uchastnikov kontrterroristicheskih operacij na Severnom Kavkaze [Post–traumatic stress and family relationships in Police Officers — Members of counterterrorism operations in the Northern Caucasus]. Psikhologicheskie issledovaniya: elektronnyi nauchnyi zhurnal [Psychological researches: electronic scientific magazine]. 2011; 3 (17): Available at: URL: http:// psystudy. ru. 0421 100116\0031
4. Burlachuk LF. Slovar’-spravochnik po psikhodiagnostike [The dictionary reference on psychodiagnostics]. SPb: Piter «Mastera psihologii» [Peter «Master of psychology»]. 2002; 528 p.
5. Prikaz MVD Rossii ot 12.01.2012 № 5 «O provedenii medico-psihologicheskoj reabilitacii sotrudnikam organov vnutrennih del Rossijskoj Federacii» [The Ministry of internal Affairs order dated 12.01.2012 № 5 «About carrying out medico-psychological rehabilitation of employees of internal Affairs bodies of the Russian Federation»].
UDC 616.127-005.8-053.9-085
DOI: 10.20969/VSKM.2016.9(6).47-51
ISAKOV LEONID K., C. Med. Sci, assistant of professor of the Department of primary health sector physician training of Kemerovo State Medical University, Russia, 650029, Kemerovo, Voroshilov str., 22a, doctor of ultrasonic diagnosis of the Medical Care unit of the Ministry of Internal Affairs of Russia in Kemerovo region, Russia, 650000, Kemerovo, Kuzbasskaya str., 10a, tel. +7-904-376-04-95, e-mail: isakovy@inbox.ru
SINKOVA MARGARITA N., C. Med. Sci., assistant of professor of the Department of primary health sector physician training of Kemerovo State Medical University, Russia, 650029, Kemerovo, Voroshilov str., 22a, tel. +7-903-048-73-31, e-mail: margov@inbox.ru
LEBEDEVA NATALIA B., D. Med. Sci., professor of the Department ofprimary health sector physician training of Kemerovo State Medical University, Russia, 650029, Kemerovo, Voroshilov str., 22a, tel. +7-903-993-10-26, e-mail: lebenb@mail.ru
TARASOV NIKOLAY I., D. Med. Sci., professor, Head of the Department of primary health sector physician training of Kemerovo State Medical University, Russia, 650029, Kemerovo, Voroshilov str., 22a, tel. +7-905-900-46-33, e-mail: tarassov53@mail.ru
VATUTIN MAXIM K., C. Med. Sci., Head of the Medical Care unit of the Ministry of Internal Affairs of Russia in Kemerovo region, Russia, 650000, Kemerovo, Kuzbasskaya str., 10a, tel. +7-906-933-96-07, e-mail: maksimvatutin@yandex.ru
MESYATS LUDMILA A., Head of the Department of functional diagnostics of the Medical Care unit of the Ministry of Internal Affairs of Russia in Kemerovo region, Russia, 650000, Kemerovo, Kuzbasskaya str., 10a, tel. +7-906-923-11-32, e-mail: mesiats@inbox.ru
Abstract. Aim. Investigation of efficacy and safety of supplemental myotropic cytoprotecton with meldonium dihydrate and of inotropic stimulation with levosimendan comparing to standard treatment of elderly patients with myocardial infarction complicated by heart failure stage II—III (Killip classification). Material and methods. 70 patients were randomized into two groups, both groups received standard therapy for complicated myocardial infarction including percutaneous transluminal coronary angioplasty. Patients at the second group additionally received meldonium and levisimendan. Results and discussion. Safety and efficiency of the therapy in treatment of complicated infarction was demonstrated. The result is due to the mutually reinforcing effects of these two drugs when administered together. Conclusions. An additional administration of Meldonium dihydrate and levosimendan in combined therapy of elderly patients with complicated myocardial infarction is safe. It leads to decrease in mortality rates as well as the frequency of relapses and severity of arrhythmic complications during hospital treatment.
Key words: myocardial infarction, elderly patient, acute heart failure, myocardial cytoprotection, inotropic stimulation.
For reference: Isakov LK, Sinkova MN, Lebedev NB, Tarasov NI, Vatutin MK, Mesyats LA. An elderly patient with complicated myocardial infarction: focus on inotropic stimulation and cytoprotection. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 47—51.
References
1. Tereshchenko SN, Golubev AV, Kositsina IV et al. Trimetazidin MV v kompleksnoy terapii ostrogo infarcta miokarda na fone sakharnogo diabeta 2 tipa [Trimetazidine MB in the treatment of acute myocardial infarction in diabetes mellitus of the 2nd type]. Kardiologiya [Cardiology]. 2006; 2: 31–34.
2. Syrkin AL. Infarct miokarda [Myocardial infarction]. M: Medicinskoe Informatisionnoe Agenstvo. 2006; 464 p.
3. Statsenko ME, Turkina SV, Lempert BA et al. Ispolzovanie metabolicheskih sredstv v kompleksnoy terapii ishemicheskoy bolezni serdtsa [The use of metabolic agents into the combined therapy of ischemic heart disease]. Lechashiy Vrach [Attending physician]. 2012; 3: 24–28.
4. Kuznetsova AV, Teplyakov AT. Otsenka vliyaniya Kardionata na effektivnost antianginalnoy teraoii I funktsionalnogo sostoyaniya miokarda u bolnih IBS v sochetanii s arterialnoy gipertenziey, assotsiirovannoy s sakharnim diabetom 2 tipa [Assessment of the impact of the Cardionat on efficiency of antianginal therapy and the functional state of the myocardium in patients with ischemic heart disease in combination with arterial hypertension combined with diabetes mellitus type 2]. Farmateka [Parmateka]. 2007; 3: 81–84.
5. Posnenkova OM, Kiselev AR, Shvarts VA et al. Vliyanie terapii preparatom Kardionat na kachestvo zhizni u bolnyh ostrym infarktom miokarda s podemom segmenta ST v rannem postinfarktnom –periode [Influence of drug therapy Cardionet on the quality of life in patients with acute myocardial infarction with ST–segment elevation in the early postinfarction period]. Consilium medicum. 2010; 5: 94–98.
6. Belenkov YN, Mareev VY, Skvortsov AA. Levosimendan novoe sredstvo dlya lecheniya dekompensirovannyh bolnyh s tyazheloj hronicheskoj serdechnoj nedostatochnostyu [Levosimendan — a new tool for the treatment of decompensated patients with severe chronic heart failure]. Serdechnaya nedostatochnost [Heart failure]. 2004; 3: 3–7.
7. Moiseyev VS, Põder P, Andrejevs N, Ruda MY, Golikov AP, Lazebnik LB, Kobalava ZD, Lehtonen LA, Laine T, Nieminen MS, Lie KI. RUSSLAN Study Investigators. Safety and efficacy of a novel calcium sensitizer, levosimendan, in patients with left ventricular failure due to an acute myocardial infarction: a randomized, placebo–controlled, double–blind study (RUSSLAN). Eur Heart J. 2002; 23 (18): 1422–32.
8. Pristrom MM, Sushinsky VE, Semenenko II. Osobennosti infarkta miokarda u pozhilyh [Features of myocardial infarction in the elderly]. Medicinskie novosti [Medical news]. 2013; 6 (225): 20–26.
ATOPIC ECZEMA TREATMENT IN ADOLESCENTS AND ADULTS: PROBLEMS AND SOLUTIONS
UDC 616.516.5-085.276
DOI: 10.20969/VSKM.2016.9(6).52-57
KAMASHEVA GULNARA R., C. Med. Sci., associate professor of the Department of general medical practice of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, e-mail:kamasheva73@rambler.ru
NADEEVA ROZALIYA А., C. Med. Sci., associate professor of the Department of general medical practice of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, e-mail: rosa.nadeeva@gmail.com
AMIROV NAIL B., D. Med. Sci., professor of the Department of general medical practice of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, deputy director of Clinical hospital of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, Kazan, Orenburgsky trakt str., 132, tel. 8-843-291-26-76, e-mail: namirov@mail.ru
Abstract. Aim. Analysis of the antecedent treatment and evaluation of effectiveness of «proactive» external treatment of atopic eczema in adolescents and adults. Material and methods. 20 patients with exacerbation of atopic eczema aged 15 to 30 [mean age (18,1±3,7)], including 13 women and 7 men were being observed. Moderate variant was seen in 85%, severe — in 15% of patients. Antecedent treatment was evaluated according to the results of survey data and medical documentations. Topical therapy consisted of daily application of 0,1% methylprednisolone aceponate until complete relief of signs of allergic skin inflammation with subsequent transition to «proactive» therapy, which consisted of intermittent application of the medication on previously affected areas of skin 2—3 times a week. Clinical efficacy was determined using SCORAD index on 2-nd, 4-th and 8-th week of treatment. Results and discussion. In 60% of patients antecedent treatment did not meet national guidelines or medical standards of care for patients with atopic eczema. Steroidophobia was detected in 60% of patients. Significant reduction of SCORAD index as well as the lesion size and intensity of pruritus compared to antecedent treatment (p<0,001) and reduced frequency of exacerbations of atopic eczema appeared as a result of therapy on 2-nd, 4-th and 8-th weeks. Conclusion. High frequency of steroidophobia and maladjustment of atopic eczema treatment to the national guidelines and standards significantly reduce the quality of treatment. «Proactive» external therapy with topical corticosteroids is effective and safe. It reduces the frequency of early relapse and extends clinical remission of the disease.
Key words: atopic eczema, adolescents, adults, «proactive» therapy, topical corticosteroids.
For reference: Kamasheva GR, Nadeeva RА, Amirov NB. Atopic eczema treatment in adolescents and adults: problems and solutions. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 52—57.
References
1. Haitov PM, Il’ina NI. Allergologija i immunologija. Nacional’noe rukovodstvo [Allergology and immunology. National guideline]. Moskva: «GJeOTAR–Media» [Moscow: «GEOTAR–Media»]. 2009; 656 p.
2. Filimonova TM, Elisjutina OG, Shtyrbul OV et al. Atopicheskij dermatit: sovremennyj vzgljad na problemu [Atopic dermatitis: a modern view on the problem]. Jeffektivnaja farmakoterapija [Effective pharmacotherapy]. 2012; 7: 36–40.
3. Akdis CA, Akdis M, Bieber T et al. Diagnosis and treatment of atopic dermatitis in children and adults: European Aca-
demy of Allergology and Clinical Immunology, American Academy of Allergy, Asthma and Immunology. PRACTALL Consensus Report. Allergy. 2006; 61: 969–987.
4. Kim JP, Chao LX, Simpson EL et al. Persistence of atopic dermatitis (AD): A systematic review and meta–analysis. J Am Acad Dermatol. 2016; 75 (4): 681–687.
5. Lebwohl M, Herrmann LG. Impaired of skin barrier function in dermatologic disease and repair with moisturization. Cutis. 2005; 76: 7–12.
6. Haitov PM, Il’ina NI. Allergologija: federal’nye klinicheskie rekomendacii [Allergology: federal clinical recommendations].
Moskva: «Farmarus Print Media» [Moscow: «Farmarus Print Media.»]. 2014; 126 p.
7. Nenasheva NM. Sovremennaja terapija atopicheskogo dermatita: rol’ jemolentov i antigistaminnyh preparatov [Modern therapy of atopic dermatitis: the role of emollients and antihistamines]. Jeffektivnaja farmakoterapija [Effective pharmacotherapy]. 2016; 6: 6–14.
8. Jeziorkowska R, Sysa–Jędrzejowska A, Samochocki Z. Topical steroid therapy in atopic dermatitis in theory and practice. Postepy Dermatol Allergol. 2015; 32 (3): 162–166.
9. Kungurov NV, Kohan MM, Keniksfest JuV et al. «Proaktivnaja» naruzhnaja terapija bol’nyh atopicheskim dermatitom detej i vzroslyh — novyj, jeffektivnyj takticheskij podhod [Proactive external therapy of children and adults, suffering from atopic dermatitis — new effective tactic approach]. Vestnik dermatologii i venerologii [Vestn Dermatol Venerol]. 2012; 3: 115—119.
10. Nenasheva NM. Osobennosti atopicheskogo dermatita u vzroslyh pacientov [Features of atopic dermatitis in adult patients]. Jeffektivnaja farmakoterapija; Dermatovenerologija i dermatokosmetologija [Effective pharmacotherapy; Dermatovenereology and dermatocosmetology]. 2012; 3: 6–14.
MEDICAL, SOCIAL AND CLINICAL CHARACTERISTICS OF ELDERLY GLAUCOMA PATIENTS
UDC 617.7-007.681-053.9(571.150)
DOI: 10.20969/VSKM.2016.9(6).58-61
MAKOGON ALEXANDER S., C. Med. Sci., associate professor, Head of the Course of eye diseases supervisor of Altay State Medical University, Russia, 656038, Barnaul, Lenin ave., 40, tel. 8-913-210-26-21, e-mail: mas65@mail.ru
MAKOGON SVETLANA I., C. Med. Sci., internal service major, ophthalmologist of the Medical Care unit of the Ministry of Internal Affairs of Russia in Altai territory, Russia, 656056, Barnaul, Anatolia str., 66, tel. 8-913-096-58-00, e-mail: vvk_msi@mail.ru
Abstract. Aim. The study of medical, social and clinical characteristics of elderly patients with glaucoma. Material and methods. The questionnaire including medical and social aspects of patients with primary open angle glaucoma was created. The survey was taken by 366 patients with glaucoma of I, II, III and IV stages living in the Altai territory and being treated at the Regional ophthalmologic Hospital. 3 groups were formed: group 1 — 104 patients of middle age (45—59 years), 42,3% (44) males and 57,7% (60) females, group 2 — 164 advanced people (60—74 years) — 40,2% (66) males and 59,8% (98) females, group 3 — 98 senile patients (75 years and older) — 36,7% (36) men and 63,3% (62) women. Results and discussion. The sociological study of glaucoma patients of different age groups showed that the patients in older age groups are characterized by higher index of comorbidity (5,4±0,3) rather than middle-aged patients (2,3±0,2). Psychological status of elderly patients was characterized by significantly lower parameters compared to those of middle aged ones. Conclusion. More than the half of senile patients rated their health as poor (62,2%), advanced persons (59,1%) and middle-aged group (70,2%) as satisfactory.
Key words: glaucoma, age groups, health and social characteristics.
For reference: Makogon AS, Makogon SI. Medical, social and clinical characteristics of elderly glaucoma patients. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 58—61.
References
1. Safarova GL. Demografija starenija: sovremennoe sostojanie i prioritetnye napravlenija issledovanij [Demography of aging: current status and research priorities]. Uspekhi gerontologii [Progress of Gerontology]. 2009; 1 (22): 49-59.
2. Baldacci E, Lugaressi S. Social expenditure and demographic evolution: a dynamic approach. Genus. 1997; 1-2: 61-78.
3. Shchepin OV. Osobennosti mediko-demograficheskoi situatsii v regionakh Rossii [Features of medico-demographic situation in Russia]. Byulleten’ Natsional’nogo NII obshchestvennogo zdorov’ya [Bulletin of the national research institute of public health]. 2007; 6: 9-15.
4. Lazebnik LB. Starenie: Professional’nyi vrachebnyi podkhod [Aging: Professional medical approach]. M: Eksmo, 2014; 320 p.
5. Neroev VV. Rezul’taty mul’titsentrovykh issledovanii epidemiologicheskikh osobennostei pervichnoi otkrytougol’noi glaukomy v Rossiiskoi Federatsii [The results of the multicentre studies epidemiological features of primary open angle glaucoma in the Russian Federation]. Rossiiskii oftal’mologicheskii zhurnal [Journal of ophthalmology]. 2013; 3: 4-7.
6. Leske MC. The Barbados Eye Study: Prevalence of open angle glaucoma. Arch Ophthalmology. 1994; 112 (6): 821–829.
7. Klein BE. Prevalence of glaucoma: The Beaver Dam Eye Study. Ophthalmology. 1992; 99 (10): 1499-1504.Ellong А. Prevalence of glaucomas in a Black Cameroonian population. Sante. 2006; 16 (2): 83-88.
9. Jonasson F. Prevalence of open-angle glaucoma in Iceland: Reykjavik Eye Study. Eye. 2003; 17 (6): 747-753.
10. Libman ES. Shakhova EV. Slepota i invalidnost’ vsledstvie oftal’mopatologii u lyudei pozhilogo i starcheskogo vozrastov v Rossii [Blindness and disability due to ophthalmopathology people of elderly and senile age, in Russia]. Samara: Materialy konferentsii «Eroshevskie chteniya» [Samara: «Eroshevsky reading»]. 2002; 427 p.
11. Anton А. Prevalence of primary open-angle glaucoma in a Spanish population: the Segovia study. J Glaucoma. 2004; 13 (5): 371-376.
12. Egorov E.A. Glaukoma: nacional’noe rukovodstvo [Glaukoma: national leadership]. Moakva [Moscow]: GEOTAR–Media. 2013; 824 p.
13. Rusina EV. Problemy glaukomnoi sluzhby v Kaliningradskoi oblasti [Problems of cataractogenesis in the Kaliningrad region]. Glaukoma: teorii, tendentsii, tekhnologii. [Glaucoma: theory, trends, technologies]. 2010; 327-332.
14. Dmitrieva TV. Povtornaya invalidnost’ vsledstvie miopii v Belgorodskoi oblasti v dinamike za 2006-2010 gody [Repeated disability due to myopia in the Belgorod region for 2006-2010 years]. Nauchnye vedomosti Belgorodskogo gosudarstvennogo universiteta; Meditsina; Farmatsiya [Scientific statements, Belgorod State University; Medicine; Pharmacy]. 2012; 10 (18/1): 148-153.
THE FEATURES OF COMORBIDITY IN PRIMARY OPEN-ANGLE GLAUCOMA PATIENTS IN DIFFERENT AGE GROUPS
UDC 617.7-007.681-053.9(571.150)
DOI: 10.20969/VSKM.2016.9(6).61-66
MAKOGON SVETLANA I., C. Med. Sci., major of internal service, ophthalmologist of the Medical Care unit of the Ministry of Internal Affairs of Russia in Altai territory, Russia, 656056, Barnaul, Anatolia str., 66, tel. 8-913-096-58-00, e-mail: vvk_msi@mail.ru
MAKOGON ALEXANDER S., C. Med. Sci., associate professor, Head of the Course of eye diseases supervisor of Altay State Medical University, Russia, 656038, Barnaul, Lenin ave., 40, tel. 8-913-210-26-21, e-mail: mas65@mail.ru
Abstract. Aim. Analysis of comorbidity in patients with primary open-angle glaucoma in different age groups. Material and methods. Analysis of 1098 patients’ data with a diagnosis of primary open-angle glaucoma of I, II, III and IV stages, who received treatment for glaucoma in Altai Regional Eye Hospital from 2013 to 2015. 3 groups were formed: group 1 — 312 middle-aged patients (45—59 years), group 2 — 492 people of advanced age (60—74 years), group 3 — 294 senile patients (75 years and older). Results and discussion. Analysis of comorbidities helps to create the conditional «portrait» of a patient with glaucoma. Thus, middle-aged patient has an index of comorbidity of 1,5 in ophthalmic pathology, cataract was seen in 37,5%, 18,0% presented with the «dry eye» syndrome and in 11,2% were diabetic changes on the fundus. The index of comorbidity on the somatic pathology is 1,7. 36,9% patients suffer from hypertension, 16,3% of thyroid disease; diseases of the digestive system are seen in 14,1% of patients. Senile patients with comorbidity index of 1,9 for eye diseases and 2,3 for somatic pathology presented with cataract in 48,0%, in 28,75% with «dry eye» syndrome, 26,8% got operated for cataract, 17,9% have senile macular degeneration; among somatic diseases: 53,9% have hypertension, 28,0% — coronary disease, COPD is seen in 21,1%, 17,3% present with encephalopathy. Senile patients with comorbidity index of 2,4 and 3,4 for ophthalmic and somatic pathology, have cataract in 62,9%, 48,0% suffer from «dry eye» syndrome, 37,4% — senile macular degeneration, 36,7% — pseudophakia. Among the somatic diseases the most prevalent are hypertension (34,7%), COPD (24,5%) and encephalopathy (25,9%). Conclusion. Comorbidity index by the ophthalmic and somatic pathology significantly increases with the age. Cataract, senile macular degeneration, hypertension, coronary heart disease and encephalopathy can be considered as syntropic for glaucoma.
Key words: comorbidity, comorbidity index, glaucoma.
For reference: Makogon SI, Makogon AS. The features of comorbidity in primary open-angle glaucoma patients in different age groups. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 61—66.
References
1. Kudrin A, Gurvich E. Starenie naselenija i ugroza bjudzhetnogo krizisa [Population aging and the threat of a budget crisis]. Voprosy ehkonomiki [Economy issues]. 2012; 3: 52–79.
2. Safarova GL. Demografija starenija: sovremennoe sostojanie i prioritetnye napravlenija issledovanij [Demography of aging: modern status and priority directions of research]. Uspekhi gerontologii [The successes of gerontology]. 2009; 1 (22): 49–59.
3. Bahmetovoj GSh, Ivankovoj LV ed. Sovremennye problemy starenija naselenija v mire: tendencii, perspektivy, vzaimootnoshenija mezhdu pokolenijami [Modern problems of population ageing in the world: trends, prospects, relationships between the generations]. M: MAKS Press. 2004; 229 p.
4. Starenie naseleniya sozdaet problemy dlya zdravoohraneniya [Population aging poses challenges to public health]. Bulletin Byulleten Vsemirnoj organizacii zdravoohraneniya [World Health Organization]. 2012; 90 (2): http://www.who.int/bulletin/volumes/90/2/12–020212/ru/
5. Shabalin VN. Organizacija raboty geriatricheskoj sluzhby v uslovijah progressirujushhego demograficheskogo starenija naselenija Rossijskoj Federacii [Organization of the work of geriatric services in a progressive demographic ageing of the population of the Russian Federation]. Uspekhi gerontologii [The successes of gerontology]. 2009; 1 (22): 186–195.
6. Shlyafer SI. Sovremennaja demograficheskaja situacija po stareniju naselenija Rossii [The present demographic situation the ageing of the population of Russia]. Glavvrach [Head physician]. 2013; 1: 39–46.
7. Rossijskij statisticheskij ezhegodnik [Russian statistical Yearbook]. 2013; http://www.gks.ru/bgd/regl/b13_13/Main.htm
8. Lazebnik LB, Konev UV, Drozdov VN, Efremov LI. Polipragmazija: geriatricheskij aspekt problemy [Of polypharmacy: geriatric aspect of the problem]. Consilium Medicum [Consilium Medicum]. 2007; 12 (9): 29–34.
9. Sobennikov VS, Belyalov FI. Somatizacija i psihosomaticheskie rasstrojstva [The somatization and psychosomatic
disorders]. Irkutsk: RIO IGIUVa. 2010; 230 p.
10. Feinstein AR. The pre–therapeutic classification of co–morbidity in chronic disease. J Chron Dis. 1970; 23: 455–469.
11. Freidin MB, Puzyrev VP. Sintropnye geny allergicheskih zabolevanij [Syntropic Genes of Allergic Diseases]. Genetika [Russian J of Genet]. 2010; 2 (46): 224–229.
12. Osipova VV, Voznesenskaya TG. Komorbidnost’ migreni: obzor literatury i podhody k izucheniju [Comorbidity of migraine: a review of the literature and approaches to learning]. ZHurnal nevrologii i psihiatrii imeni SS Korsakova [Journal of Neurology and Psychiatry SS Korsakoff’s]. 2007; 3: 64–73.
13. Kisely S, Goldberg D. Physical and psychiatric Comorbidity in general practice. British Journal of Psychiatry. 1996; 169: 236–242.
14. Petrik EA. Osobennosti polimorbidnosti u somaticheskih bol’nyh [Especially polymorbidity of patients have somatic]. Moskva [Moscow]. 2011; 114 p.
15. Belyalov FI. Lechenie vnutrennih boleznej v uslovijah komorbidnosti [Treatment of internal diseases in the context of comorbidity]. Irkutsk: RIO IGIUVa. 2011; 305 p.
16. Salisbury C, Johnson L, Purdy S et al. Epidemiology and impact of multimorbidity in primary care: a retrospective cohort study. The British Journal of General Practice. 2011; 61 (582): 12–21.
17. Arev AL, Ovsyannikova NA, Areva GT et al. Polimorbidnost’ v geriatrii [The polymorbidity in geriatrics]. Prakticheskaya onkologiya [Practical oncology]. 2015; 3: 63–90.
18. Vertkin AL, Rumyancev MA, Skotnikov AS. Komorbidnost’ v klinicheskoj praktike [Comorbidity in clinical practice]. Arhiv» vnutrennej mediciny [Arhiv Internal Medicine]. 2011; 2: 20–24.
19. Briskin BS. Polimorbidost’ pozhilyh i hirurgicheskie problem [Polymorbidity elderly and surgical problems]. Klinicheskaya gerontologiya [Clinical gerontology]. 2007; 5: 3–7.
20. Aksamentov GB. Klinicheskie i funkcional’nye osobennosti pacientov geriatricheskogo stacionara [Clinical and functional characteristics of patients of the geriatric hospital]. Zdravoohranenie [Health service]. 2002; 2: 51–54.
21. Fesenko EH. V., Poveda A. G., Poveda V. A. i dr. Polimorbidnost’ v pozhilom vozraste i problemy priverzhennosti [The polymorbidity in the elderly and problems of commitment]. Nauchnye vedomosti Belgorodskogo gosudarstvennogo universiteta. Seriya: Medicina. Farmaciya. [Scientific statements Belgorod State University. Series: Medicine. Pharmacy]. 2012; 10-11 (129): 15-16.
UDC 616.12-008.331.1-037:616.133-073.432.19
DOI: 10.20969/VSKM.2016.9(6).67-72
MAYANSKAYA SVETLANA D., D. Med. Sci., professor of the Department of hospital terapy of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. (843)236-09-22, e-mail: smayanskaya@mail.ru
GREBYONKINA IRINA A., C. Med. Sci., associate professor of the Department of outpatient medicine and general practice (family medicine) of Novosibirsk State Medical University, Russia, 630092, Novosibirsk, Кrasniy ave., 52, tel. 8-913-928-41-16, e-mail: iren-quaf@yandex.ru
OSHCHEPKOVA OLGA B., Head of the Department of cardiology of Hospital of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, Russia, 420059, Kazan, Orenburgsky tract str., 132, tel. 8-905-039-43-55, e-mail: oschepkova.kazan@mail.ru
MIKHOPAROVA OLGA YU., Head of the Department of functional diagnostics of Hospital of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, Russia, 420059, Kazan, Orenburgsky tract str., 132, tel. 8-937-525-53-61, e-mail: Olga-mihoparova@rambler.ru
Abstract. Aim. Evaluation of the intima-media thickness of the common carotid artery in young individuals with family history of hypertension. Material and methods. The study included 104 individuals [62 women and 42 men, mean age (23,9±2,7) years] with family history of hypertension. Control group consisted of 36 persons of the same age and gender, but without hypertension in family history. All of them have undergone outpatient blood pressure monitoring, ultrasound of the carotid arteries as well as they had blood lipids test. Results and discussion. According to the blood pressure monitoring results all patients were divided into 3 groups: 1 — hypertensive patients; 2 — persons with high normal blood pressure; 3 — persons with normal blood pressure. Statistically significant increase of common carotid artery intima-media thickness and common carotid artery diameter in systole in groups 1 and 2 compared to patients of 3-d and the control group (p<0,001; p<0,01; p<0,05) was revealed. In addition, patients with hypertension presented with association of common carotid artery intima-media thickness with age, the average daily level of systolic blood pressure, diastolic blood pressure and pulse pressure as well as the degree of reduction in diastolic blood pressure and night level of total serum cholesterol. Conclusion. The results of evaluation of common carotid artery intima-media thickness in patients with family history of hypertension may have a prognostic value in the development of hypertension and atherosclerosis. Revealed increase of common carotid artery intima-media thickness in patients with high normal blood pressure even before the development of hypertension proposes its primary nature.
Key words: hypertension, hereditary load, common carotid artery, the thickness of the intima-media complex.
For reference: Mayanskaya SD, Grebenkina IA, Oshchepkova OB, Mihoparova OJ. Intima-media thickness of common carotid artery as an early predictor of arterial hypertension in patients with hereditary load. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 67—72.
References
1. Pereira М, Lunet M, Azeved A et al. Differences in prevalence, amareness, treatment and control of hypertension between developing and developed countries. Hypertension. 2009; 27: 1817–1823.
2. Volp М. Cardiovascular risk assessment beyong systemic coronary risk estimation: a role for organ damage markers. J Hypertension. 2012; 30: 1056–1064.
3. Nambi V. Carotid intima–media thickness and presence or absence plaque improves prediction of coronary heart disease risk: the ARIC (Atherosclerosis Risk in Communities) study. J Am Coll Cardiol. 2010; 55: 1600–1607.
4. Peters SA, Jensen RE, Parnell R. Improvements in risk stratificationfor the occurrence of cardiovascular disease by imaging subclinical atherosclerosis: a systematic review. Heart. 2012; 98: 177–184.
5. Ostroumova OD, Zhukova V, Erofeeva A. Tolshhina kompleksa intima–media sonnyh arterij u bol’nyh AG — vozmozhnosti fiksirovannoj kombinacii Logimaks [Thickness intima–media complex of the carotid arteries in patients with hypertension — the possibility of a fixed combination Logimax]. RMJ [Russian medicine magazine]. 2009; (8): 548–562.
6. Vanhoutte PM. Endothelial dysfunction in hypertension. J Hypertension Suppl. 1996; 14 (5): 83–93.
7. Boytsov SA, Karpov YU, Kukharchuk VV. Problemy vyjavlenija lic s vysokim serdechno–sosudistym riskom i vozmozhnye puti ih reshenija [Problems of identification of individuals with high cardiovascular risk and possible ways of their solution]. Ateroskleroz i dislipidemii [Atherosclerosis and dyslipidemia]. 2010; 1: 9–14.
8. Diagnostika i lechenie arterial’noj gipertonii: klinicheskie rekomendacii [Diagnosis and treatment of arterial hypertension:
clinical guidelines]. Moskva [Moscow]. 2013; http://www.scardio.ru/content/Guidelines/ESChypertension2013.
pdf
9. ESH / ESC 2013 / Rabochaja gruppa po lecheniju arterial’noj gipertonii Evropejskogo Obshhestva Gipertonii (European Society of Hypertension, ESH) i Evropejskogo Obshhestva Kardiologov (European Society of Cardiology, ESC) [ESH/ESC 2013]. Rekomendacii po lecheniju arterial’noj gipertonii [Recommendations for the management of arterial hypertension]. 2014; 1: 7–94.
10. Bockeria LA, Oganov RG ed. Vse o holesterine: nacional’nyj doklad [All about cholesterol: a national report submitted]. Moskva: OOO «Liga zdorov’e nacii» [Moscow: OOO “League of health of the nation”]. 2010; 180 p.
11. Michel E, Safar MD, Bernard I, Levy MD. Current рerspectives on аrterial stiffness and pulse pressure in hypertension and cardiovascular diseases. Curculation. 2003; 10: 2864–2869.
12. Kieltyka L, Urbina E, Tang R. Framingham risk score to carotid intima–media thickness in both white and black young adult: the Bogalusa Heart Stud. Aterosclerosis. 2003; 170 (1): 125–130.
13. Laurent S, Cockroft J, Bortel L. Expert consensus document on arterial stiffness: methodological issues and clinical applications. European Heart Journal. 2006; 27: 2588–2606.
14. Diagnostika i korrekcija narushenij lipidnogo obmena s cel’ju profilaktiki i lechenija ateroskleroza, Rossijskie rekomendacii, V peresmotr [Diagnosis and correction of lipid metabolism disorders prevention and treatment of atherosclerosis, Russian recommendations (IV revision)]. Cardiovascular therapy and prevention
UDC 616-057.36-084(470.64)
DOI:10.20969/VSKM.2016.9(6).72-76
MURTAZOV ALBERT M., C. Med. Sci., Head of the Center of psychophysiological diagnostics of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Kabardino-Balkar Republic, the colonel of internal service, Russia, 360000, Nalchik, M. Gorky str., 7, tel. 8-928-711-44-10
SHOGENOV AKHMED G., C. Med. Sci., Head of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Kabardino-Balkar Republic, the colonel of internal service, Russia, 360000, Nalchik, M. Gorky str., 7, tel. 8 (8662) 44-28-11, e-mail: mdo.kbr@list.ru
ELGAROV ANATOLY A., D. Med. Sci., professor, general practitioner of Clinic outpatient of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Kabardino-Balkar Republic, Russia, 360000, Nalchik, M. Gorky str., 7, tel. 8-928-589-58-58
KRAVTSOV ALEXANDER V., С. Psych. Sci., deputy head of the Center of psychophysiological diagnostics of the Medical Care unit of the Ministry of Internal Affairs of Russia in Kabardino-Balkar Republic, major of internal service, Russia, 360000, Nalchik, M. Gorky str., 7, tel. 8-928-913-57-82
MAKITOVA MARIANNA P., doctor-supervisor of the Department of organizational methodical medical and preventive provision of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Kabardino-Balkar Republic, senior lieutenant of internal service, Russia, 360000, Nalchik, M. Gorky str., 7, tel. 8 (8662) 49-44-63
ASHKHOTOV ELBERD R., C. Med. Sci., Head of the Hospital of the Medical Care unit of the Ministry of Internal Affairs of Russia in Kabardino-Balkar Republic, major of internal service, Russia, 360000, Nalchik, M. Gorky str., 7, tel. 8 (8662) 49-49-05
ZHIRIKOV ALIM YU., Head of Clinic outpatient of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Kabardino-Balkar Republic, senior lieutenant of internal service, Russia, 360000, Nalchik, M. Gorky str., 7, tel. 8 (8662) 49-45-88
Abstract. Current issues of medical and psychological support of activities of internal affairs bodies’ employees are being discussed. Aim. Assessment of effectiveness of comprehensive medical and psychological support of employees of Internal Affairs bodies taking into account specifics of professional activities in North Caucasus region. Material and methods. Epidemiological survey of 390 1st and 2nd intent group employees of internal Affairs bodies aged 30—55 years with 10 year duration of service before and after preventative and individual rehabilitation measures was carried out. Results and discussion. Due to gradual implementation in the Federal state healthcare institution «Medical unit of the Ministry of internal affairs of Russia in the Kabardino-Balkar Republic» departmental profile, «Center for restorative medicine and rehabilitation of the Ministry of internal affairs of Russia» a positive dynamics of important physiological parameters and clinical-dynamic indicators of health was seen in police officers with stress-induced adjustment disorder and hypertensive reactions. The possibility of increasing levels of adoption and active use of modern technologies in the Center for psychophysiological diagnostics was seen in assessment of the effectiveness of diagnostic, therapeutic and rehabilitation activities in departmental health on the basis of analysis of the results. Conclusion. Systematic set of measures aiming for implementation of medical and psychological rehabilitation should be considered as effective rehabilitation program in the framework of medical and psychological support organization ensuring professional longevity of Internal Affairs bodies’ employees.
Key words: medical and psychological support, monitoring, prevention, professional longevity, police.
For reference: Murtazov AM, Shogenov AG, Elgarov AA. Kravtsov AV, Makitova MP, Ashkhotov ER. Twenty year experience of the medical and psychological support of activities of employees of internal affairs bodies. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 72—76.
References
1. Miagkih NI, Shutko GV, Ermachkov AI. Materialy vystuplenij uchastnikov Vserossijskoj nauchno-prakticheskoj konferencii, posvjashhjonnoj 35-letiju sozdanija sistemy professional’nogo psihologicheskogo otbora v OVD [Proceedings of the participants of All-Russian scientific-practical conference devoted to the 35th anniversary of the establishment of professional psychological selection system in the police department]. MVD Rossii [The Russian Interior Ministry]. 2008; 158 p.
2. Potapova MV. Nekotorye aspekty politiki mediko-sanitarnoj chasti MVD po RT [Some aspects of the health of the Ministry of Interior in Tatarstan policy]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Contemporary Clinical Medicine]. 2008; 1 (1): 6-7.
3. Petrov VE, Shutko GV. Sbornik materialov nauchno-prakticheskoj konferencii, posvjashhjonnoj 40-letiju sozdanija sistemy professional’nogo psihologicheskogo otbora v OVD [The collection of materials of scientific-practical conference devoted to the 40th anniversary of the establishment of professional psychological selection system in the police department]. Domodedovo: VIPK MVD Rossii [Domodedovo: the Russian Interior Ministry]. 2013; 266 p.
4. Shogenov AG, Murtazov AM, Elgarov AA. Medicina truda lic opasnyh professij [Labour Medicine hazardous occupations persons]. Medicina truda i promyshlennaja jekologija [Occupational Medicine and Industrial Ecology]. 2007; 5: 1-6.
5. Shogenova AB, Elgarov AA, Murtazov AM, Shogenov AG. Metabolicheskij sindrom i risk serdechno-sosudistyh zabolevanij u sotrudnikov pravoohranitel’nyh organov [Metabolic syndrome and risk of cardiovascular disease in law enforcement]. Medicina truda i promyshlennaja jekologija [Occupational Medicine and industrial ecology]. 2010; 11: 7-12.
6. Koshelev VP, Kornyushko IG, Bugrov VI, Ermilova EV. Zdorov’e cheloveka i ego mirovozzrenie [Human health and his world MVD]. Medicinskij vestnik MVD [Medical Bulletin MIA]. 2012; 2: 26-29.
7. Doll R, Peto R. The causes of cancer-quantitative estimates of avoidable risks of cancer in the United-States today. Journal of the National Cancer Institute. 2011; 66.
8. Kasatkin VN, Bochaver AA. Aktual’nye problemy psihologii zdorov’j [Actual problems of health psychology]. Psihologicheskaja nauka i obrazovanie [Psychological Science and Education]. 2010; 5: 255 p.
9. Johnston M, Dixon D. Current Issues and New Directions in Psychology and Health: What happened to behaviour in the decade of behavior. Psychology and health. 2008; 23.
10. Kaplan RM. Health Psychology: Where Are We And Where Do We Go From Here. Health psychology. 2009; 7.
11. Chukhnin EV, Amirov NB. Variabel’nost’ serdechnogo ritma: metodicheskoe i klinicheskoe primenenie [Heart rate variability: methodical and clinical application]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Сontemporary Сlinical Medicine]. 2008; 1 (1): 72-78.
UDC 616.34-009-052
DOI: 10.20969/VSKM.2016.9(6).76-81
SPIRIDONOV ALBERT V., C. Med. Sci., deputy chief of Clinical hospital of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, Russia, 420059, Kazan, Orenburgsky trakt str., 132, tel. +7(843) 291-86-94, e-mail: 89046668452@bk.ru
ABSALJAMOVA LEJLE R., Head of the Department of gastroenterology of Clinical hospital of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, Russia, 420059, Kazan, Orenburgsky trakt str., 132, tel. +7(843) 291-86-8, e-mail: 89046668452@bk.ru
GIMALETDINOVA IRINA A., gastroenterologist of Clinical hospital of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, Russia, 420059, Kazan, Orenburgsky trakt str., 132, tel. +7(843) 291-86-85, e-mail: 89046668452@bk.ru
Abstract. Aim. Quality of life assessment in persons with irritable bowel syndrome among the office workers. Material and Methods. 32 patients with irritable bowel syndrome aged 19—46 years were examined. Statistical processing was performed using Statistica 7 software. Statistical methods such as comparison of relative values and variation series methods of nonparametric statistics were applied. The level of significance was estimated as p˂0,05. Results and discussion. The category of office workers were classified as persons who take sitting position with low physical activity 60% or more working time. The diagnosis of irritable bowel syndrome and the disease form were set according to the Rome criteria III. Depending on the form of irritable bowel syndrome the patients were divided into groups: irritable bowel syndrome with constipation, irritable bowel syndrome with diarrhea, mixed irritable bowel syndrome and undifferentiated irritable bowel syndrome. The patients having the symptoms of anxiety were excluded from the study. Conclusion. The quality of life assessment according to the simplified (short) questionnaire on the outpatient treatment by the World Health Organization allows the doctor to evaluate the internal condition of the patient reasonably prior to the medical treatment, to assess effectiveness of the therapy at the follow-up control, to identify the worsening of quality of life indicators timely as well as to carry out the diagnosis of possible functional abnormalities.
Key words: irritable bowel syndrome, quality of life, diagnostics, clinic.
For reference: Spiridonov AV, Absaljamova LR, Gimaletdinova IA. Appliance of the short questionnaire of WHOQOL-BREF by the WHO for quality of life assessment in irritable bowel syndrome patients. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 76—81.
References
1. Ivashkin VT, Polujektova EA. Sindrom razdrazhennogo kishechnika: patofiziologicheskie i klinicheskie aspekty problemy [Sindrom of the angry intestines: pathophysiological and clinical aspects of a problem]. Rossijskij zhurnal gastrojenterologii, gepatologii, koloproktologii [Russian magazine of gastroenterology, hepatology, coloproctology]. 2015; 25 (1): 4-16.
2. Spiridonov AV, Gimaletdinova IA, Absaljamova LR. Sindrom razdrazhennogo kishechnika v praktike vracha-gastrojenterologa: ot mehanizmov vozniknovenija do jeffektivnoj terapii [A syndrome of the angry intestines in practice of the gastroenterologist: from origins before]. Vestnik sovremennoj klinicheskoj mediciny [Messenger of modern clinical medicine]. 2015; 8 (6): 79-85.
3. Spiridonov AV, Shigabutdinova FG, Spiridonova AV. Funkcional’nye zabolevanija organov pishhevarenija; sindrom razdrazhennogo kishechnika v praktike vracha, podhody k terapii — uchebno-metodicheskoe posobie [Functional diseases of the digestive system; a syndrome of the angry intestines in practice of the doctor, approaches to therapy — education guidance]. Kazan’: Vestfalica. 2015; 38 p.
4. Ivashkin VT, Sheptulin AA. Boli v zhivote [Belly-aches]. Moskva: MEDpress-inform [Moscow: the medical press-inform]. 2012; 112 p.
5. Ivashkin VT. Klinicheskie rekomendacii Rossijskoj gastrojenterologicheskoj associacii, Associacii koloproktologov Rossii po diagnostike i lecheniju bol’nyh s sindromom razdrazhennogo kishechnika RZhGGK [Clinical recommendations of the Russian gastroenterologichesky association, Association of coloproctologists of Russia about diagnostics and treatment of patients with a syndrome of the angry intestines of RZhGGK]. 2014; 24 (2): 92-101.
6. Ziganshina LE, Lepahin VK, Petrov VI, Habriev RU ed. Bol’shoj spravochnik lekarstvennyh sredstv [Big reference book of medicines]. Moskva: GJeOTAR-Media [Moscow: GEOTAR-media]. 2011; 3344 p.
7. Gurevich MM. Lechebnoe pitanie: sovety gastrojenterologa [Medical foods: recommendations of the gastroenterologist]. Moskva [Moscow]: Jeksmo. 2012; 320 p.
8. Ivashkin VT. Sindrom razdrazhennoj kishki: Prakticheskoe rukovodstvo dlja vrachej [Syndrome of the angry gut: A practice guidance for doctors]. Moskva [Moscow]: RGA. 1999; 28 p.
9. Mahov VM, Romasenko LV, Turko TV, Sheptak NN. Sindrom razdrazhennogo kishechnika — komorbidnoe somatopsihicheskoe zabolevanie [The syndrome of the angry intestines — a komorbidny somatopsikhichesky disease]. Lechashhij Vrach [Attending physician]. 2014; 8: 10-14.
10. Mahov VM, Romasenko LV, Turko TV. Komorbidnost’ disfunkcional’nyh rasstrojstv organov pishhevarenija [Komorbidnost of dysfunctional frustration of digestive organs]. Russkij Medicinskij Zhurnal: bolezni organov pishhevarenija [Russian Medical Magazine: diseases of digestive organs]. 2007; 9 (2): 37–42.
11. Nemcov VI. Sindrom razdrazhennogo kishechnika: novye predstavlenija ob jetiopatogeneze i lechenii [Syndrome of the angry intestines: new ideas of an etiopatogeneza and treatment]. Lechashhij vrach [Attending physician]. 2015; 6: http: //www.lvrach.ru/ 2015/06/15436246/
12. Spiridonov AV. Rol’ fitoterapii pri sindrome razdrazhennogo kishechnika [A phytotherapy role in case of a syndrome of the angry intestines]. Nauchnyj al’manah [The Scientific almanac]. 2015; 8 (10): 989-1001.
13. Jakovenko AV, Ivanov AN, Prjanishnikova AS, Agafonova NA, Jakovenko JeP. Patogeneticheskie podhody v lechenii sindroma razdarzhennogo kishechnika [Pathogenetic approaches in treatment of a syndrome of razdarzhenny intestines]. Lechashhij vrach [The attending physician]. 2011; 7: http://www.lvrach.ru/2011/07/15435230
UDC 613.81-057.36(470.332)
DOI: 10.20969/VSKM.2016.9(6).82-84
TIMOFEEV SERGEY I., Head of the Medical Care unit of the Ministry of Internal Affairs of Russia in Smolensk region, colonel of internal service, Russia, 214000, Smolensk, Oktiaborskaya revolutsiya str., 14, tel. (4812) 65-31-51
SERGEENKO ZHANNETA I., Head of the Hospital of the Medical Care unit of the Ministry of Internal Affairs of Russia in Smolensk region, lieutenant colonel of internal service, Russia, 214000, Smolensk, Oktiaborskaya revolutsiya str., 14, tel. (4812) 40-50-97
LISTOPADOVA MARIA V., C. Med. Sci., physician of the Hospital of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Smolensk region, Russia, 214000, Smolensk, Oktiaborskaya revolutsiya str., 14, tel. 8-950-705-26-76, e-mail: listopadovamasha@mail.ru
GUBANKOVA GALINA V., functional diagnostics physician of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Smolensk region, Russia, 214000, Smolensk, Oktiaborskaya revolutsya str., 14, tel. (4812) 77-38-97
LITVINOVA EKATERINA S., student of Smolensk State Medical University, Russia, 214019, Smolensk, Krupskaya str., 28, tel. 8-961-138-34-40
SHPAKOV ALEXANDER V., resident of the Department of general practice with a course of outpatient medicine of Smolensk State Medical University, Russia, 214019, Smolensk, Krupskaya str., 28, tel. 8-910-767-76-28
Abstract. Aim. To assess effectiveness of monitoring management as well as the outpatient medical care provided for smoking certified employees on the basis of Medical Unit of the Ministry of Internal Affairs of Russia in Smolensk region. Material and methods. The study included certified employees with the history of smoking at the time of the clinical examination in 2015. The basis of the monitoring organization was the letter of the Ministry of Health and Social Development of the Russian Federation from May 5, 2012 № 14-3/10/1-2817 «Providing healthcare to adults for the smoking prevention and cessation». Results and discussion. 39,9% (n=46) of respondents had high level of nicotine dependence, 27,6% and 21,5% of smokers had average and low degree of dependence respectively. 29,4% of the employees had high motivation to give up smoking initially. Taking smoking status in consideration differential approach of medical care was applied. During individual monitoring 41,4% (n=48) certified employees gave up smoking; 50,8% (n=59) of smokers reduced the number of cigarettes per day and decided to complete smoking cessation. Conclusion. Results of this study confirm the effectiveness of individual monitoring of assistance in smoking cessation. Necessity of comprehensive approach in organization of individual consultations, education and training of smoking employees is verified.
Key words: smoking, smoking cessation.
For reference: Timofeev SI, Sergeenko JI, Listopadova MV, Gubankova GV, Litvinova ES, Shpakov AV. Organization of monitoring of smoking in certified employees on the basis of medical unit of the Ministry of Internal Affairs of Russia in Smolensk region. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 82—84.
References
1. Zaridze DG, Karpov RS, Kiseleva SM. Kurenie — osnovnaja prichina vysokoj smertnosti rossijan [Smoking –– the main reason for the high death rate of Russians]. Vestnik RAMN [Herald RAMN]. 2002; 9: 40–45.
2. Global’nyj opros vzroslogo naselenija o potreblenii tabaka (GATS), stranovoj otchet [The global survey of adults about tobacco use (GATS)]. Rossijskaja Federacija [Russian Federation]. 2010; 172 p.
3. Amirov NB, Andreeva TI. Tabachnaja jepidemija: Farmakologicheskie vozmozhnosti bor’by [The tobacco epidemic: The pharmacological possibilities of struggle]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Contemporary Clinical Medicine]. 2011; 4 (3): 28––33.
4. Krivonos OV, Bojcov SA, Gambarjan MG, Kalinina AM. Okazanie medicinskoj pomoshhi po profilaktike i otkazu ot kurenija: metodicheskie rekomendacii Minzdrava Rossii [Providing medical care for the smoking prevention and cessation: Russian Ministry of Healthcare guidelines]. Moskva: «Gosudarstvennyj nauchno––issledovatel’skij centr profilakticheskoj mediciny» Minzdravsocrazvitija Rossii [Moscow: «State Research Center for Preventive Medicine,» Health Ministry of Russia]. 2012; 42 p.
5. Najdenova NE, Dmitrieva EE, Zubareva NN. Opyt okazanija medicinskoj pomoshhi po otkazu ot kurenija v uslovijah centra zdorov’ja [The experience of medical care for smoking cessation in a health center]. Zamestitel’ glavnogo vracha [Deputy vracha]. 2014; 10 (101): 23–32.
UDC 616.12-008.331.1-057.36(470.41)
DOI: 10.20969/VSKM.2016.9(6).85-89
FROLOVA ELVIRA B., C. Med. Sci., deputy head of Clinical hospital of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, Russia, 420059, Kazan, Orenburgsky trakt str., 132, e-mail: frolova.67@mail.ru
SAFARGALIYEVA LILIYA KH., Head of the Department of internal medicine of Clinical hospital of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, Russia, 420059, Kazan, Orenburgsky trakt str., 132, e-mail: safargalieva.lilia@mail.ru
YAGFAROVA RITA R., physician of the Department of internal medicine of Clinical hospital of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, Russia, 420059, Kazan, Orenburgsky trakt str., 132
MIKHOPAROVA OLGA YU., Head of the Department of functional diagnostics of Clinical hospital of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, Russia, 420059, Kazan, Orenburgsky trakt str., 132, e-mail: olga-mihoparova@rambler.ru
SHARIPOVA ROZALIA R., physician of the Department of internal medicine of Clinical hospital of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, Russia, 420059, Kazan, Orenburgsky trakt str., 132, e-mail sharipova.7@mail.ru
URGADULOVA KSENIYA V., resident of the Department of cardiology, roentgen-endovascular and cardiovascular surgery of Kazan State Medical Academy, Russia, 420012, Kazan, Mushtari str., 11
ULANOVA ALEXANDRA D., resident of the Department of cardiology, roentgen-endovascular and cardiovascular surgery of Kazan State Medical Academy, Russia, 420012, Kazan, Mushtari str., 11
Abstract. Aim. To perform retrospective comparative study of 235 patients with arterial hypertension. Material and methods. We included in the study the patients with arterial hypertension with the absence of co-morbidities for the period from 2011 to 2015. Chi-square nonparametric method was used to identify the frequency of outcomes depending on the factor. Results and discussion. The results demonstrate that on average patients had hypertension stage I or II and the second group of risk with normal and subnormal echocardiographic parameters of cardiac function. Thus, the indicators of daily blood pressure monitoring showed no or insufficient pressure decrease at night in half of the patients. Conclusion. 5 year comparative analysis has demonstrated that the clinical profile of the patients with arterial hypertension has not changed. The most important tool for the diagnosis of arterial hypertension on the early stages is 24-hour blood pressure monitoring.
Key words: arterial hypertension, 24-hour blood pressure monitoring.
For reference: Frolova EB, Safargaliyeva LH, Yagfarova RR, Mihoparova OY, Sharipova RR, Urgadulova KV, Ulanova AD. Comparative analysis of clinical and functional indicators of the patients with arterial hypertension and no comorbidity in 5 years. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 85—89.
References
1. Shal’nova SA, Kukushkin SK, Manoshkina EM, Timofeeva TN. Arterial’naja gipertenzija i priverzhennost’ terapii [Arterial hypertension and compliance]. Vrach [Doctor]. 2009; 12: 39—42.
2. Global Health Observatory (GHO) data. Raised blood pressure. Situation and trends. url=http://www.who.int/gho/ncd/risk_factors/blood_pressure_prevalence_text/en/
3. Amirov NB, Vizel’ AA, Potapova MV, Ishkineev FI, Frolova JeB, Merikova EF, Iskandarova VV, Afanas’eva JuA, Sokolova OR, Husnutdinova RG. Chastota i osobennosti formirovanija gipertenzivnogo sindroma i faktorov riska CCP u rabotnikov MVD i MChS, rabotajushhih v avtoinspekcii i v pozharnoj sluzhbe [Frequency and characteristics of hypertensive syndrome and cardiovascular risk factors of Ministry of Interior and Ministry of Emergency Situations officers working in the traffic police and the fire service]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Contemporary Clinical Medicine]. 2008; 1: 93—95.
4. Davhale R, Potapova MV, Amirov NB. Rasprostranennost’ arterial’noj gipertenzii sredi sotrudnikov pravoohranitel’nyh organov (obzor literatury) [Prevalence of аrtеrial hipertension among the employees of law—enforcement bodies: a review]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Contemporary Clinical Medicine]. 2013; 6 (2): 66—72.
5. Amirov NB, Andreeva TI. Tabachnaja jepidemija: farmakologicheskie vozmozhnosti bor’by [The tobacco epidemic: pharmacological control features]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Contemporary Clinical Medicine]. 2011; 4 (3): 28—33.
6. Amirov NB. Profilaktika, diagnostika i lechenie arterial’noj gipertenzii; osnovnye polozhenija, tablicy, shemy i kommentarii k rossijskim rekomendacijam 2008 goda (v pomoshh’ prakticheskomu vrachu) [Prevention, diagnosis and treatment of hypertension; the main provisions, tables, charts and comments on the recommendations of the Russian 2008 (to assist the practitioner)]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Contemporary Clinical Medicine]. 2009; 2 (1): 49—65.
7. Amirov NB ed. Voprosy kliniki, diagnostiki, differencial’noj diagnostiki, lechenija i profilaktiki arterial’nyh gipertenzij (Uchebno metodicheskoe posobie dlja slushatelej poslevuzovskogo i dopolnitel’nogo professional’nogo obrazovanija [Clinic, diagnosis, differential diagnosis, treatment and prevention of arterial hypertension (Study guideline for students of postgraduate and additional professional education)]. Kazanskij gosudarstvennyj medicinskij universitet [Kazan State Medical University]. 2010; 127 p.
8. Amirov NB, Chuhnin EV. Risk vnezapnoj smerti i chastota serdechnyh sokrashhenij [The risk of sudden death and heart beats frequency]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Contemporary Clinical Medicine]. 2010; 4: 47—48.
9. Potapova MV, Mihoparova OJu, Amirov NB, Sabirov LF, Frolova JeB. Analiz dinamiki dejatel’nosti sluzhby funkcional’noj diagnostiki Klinicheskogo gospitalja MSCh MVD Rossii po Respublike Tatarstan [Analysis of the dynamics of service of functional diagnostics of Clinical hospital of medical unit of MIA of Rrussia in RT]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Contemporary Clinical Medicine]. 2012; 5 (3): 19—25.
10. Hisamiev RSh, Ginjatullina LR, Amirov NB. Vedomstvennoe zdravoohranenie MVD po Respublike Tatarstan: realii i perspektivy [Departmental health care of ministry of the interior in the Tatarstan Repablic: reality and perspectives]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Contemporary Clinical Medicine]. 2014; 7 (suppl. 1): 11—15.
UDC 616.12-008.331.1-057.36(470.41-25)
DOI: 10.20969/VSKM.2016.9(6).89-95
KHISAMIEV RUSTEM SH., major of internal service, Head of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, Russia, Kazan, Lobachevsky str., 13, e-mail: khisamru@mail.ru
AMIROV NAIL B., D. Med. Sci., professor of the Department of general practice of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, deputy head of Clinical hospital of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, Russia, Kazan, Orenburgsky trakt str., 132, e-mail: namirov@mail.ru
GINJATULLINA LAJSAN R., lieutenant colonel of internal service, deputy head of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, Russia, Kazan, Lobachevsky str., 13, e-mail: 1610med@mail.ru
FATYKHOV NIJAZ SH., senior lieutenant of internal service, Head of the Clinic of the outpatient of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, Russia, Kazan, Lobachevsky str., 13, e-mail: niaz81@mail.ru
MERIKOVA ELENA F., major of internal service, deputy head of Clinic of the outpatient of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, Russia, Kazan, Lobachevsky str., 13, e-mail: elenamerikova@gmail.com
JAKIMETS SVETLANA A., Head of the Department of internal medicine № 2 of Clinic of the outpatient of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, Russia, Kazan, Lobachevsky str., 13, e-mail: lanastar2011@mail.ru
Abstract. Aim. To study the influence of modifiable and non-modifiable risk factors on the development of hypertension in police officers as well as the possible ways of cardiovascular disease prevention, taking into account the specifics of the work during annual clinical examination. Material and methods. As a part of the annual medical examination 9 616 employees of internal service were recruited to the study. Dynamics of the data on the state of health from annual medical examination for the period 2011—2015 were studied. The work has been carried out according to the regulatory documents of the Ministry of internal and of the Ministry of health affairs of the Russian Federation. Results and discussion. It was found that out of 9289 employees of internal service of Kazan garrison, who had undergone clinical examination in 2015, only 1 061 (11,4%) are registered at the general practitioners. Among those there are 242 persons with hypertension (2,6% of the total number of internal service officers, and 22,8% of all the dispensary accounting). Among the 22,8% of patients with hypertension the proportion of females was 9,7% (23 women). The number of men with hypertension is 213 (90,2%). It was found that all patients with hypertension are characterized by the modifiable risk factors for cardiovascular disease (smoking, excess weight gain, dyslipidemia), target organs affected (left ventricular hypertrophy, peripheral arterial disease), non-modifiable risk factors (family history) and by comorbidities including type 2 diabetes. Conclusion. The prevalence of hypertension among police officers is lower than in the general population. The incidence of risk factors for cardiovascular diseases in individuals diagnosed with hypertension does not differ from the average population. In order to prevent development of hypertension and its complications among police officers it is necessary to strengthen all measures aiming to prevent cardiovascular disease, to promote healthy lifestyle and to improve rehabilitation.
Key words: hypertension, police officers, medical examination.
For reference: Hisamiev RSh, Amirov NB, Ginjatullina LR, Fatyhov NSh, Merikova EF, Jakimec SA. Comparative analysis of the incidence of hypertension and of the prevalence of risk factors among internal affairs bodies of Kazan garrison. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 89—95.
References
1. Abdrakhmanova AI, Amirov NB, Cibul’kin NA. Medikamentoznoe lechenie arterial’noj gipertenzii i ego pobochnye jeffekty u pacientov starshego vozrasta [Drug treatment of hypertension and its side effekty older patients]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of contemporary clinical medicine]. 2016; 9 (2): 110-116.
2. Davhale R, Potapova MV, Amirov NB. Rasprostranennost’ arterial’noj gipertenzii sredi sotrudnikov pravoohranitel’nyh organov (obzor literatury) [The prevalence of hypertension among law enforcement officers (literature review)]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of contemporary clinical medicine]. 2013; 6 (2): 66-73.
3. Amirov NB, Andreeva TI. Tabachnaja jepidemija: farmakologicheskie vozmozhnosti bor’by [The tobacco epidemic: the pharmacological possibilities of struggle]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of contemporary clinical medicine]. 2011; 4 (3): 28-33.
4. Jablonskij PK, Suhovskaja OA. Jelektronnye sigarety — «sposob kurenija» ili sredstvo otkaza ot kurenija? Kommentarij k stat’e V.D. Mendelevicha [Electronic cigarettes — «method of smoking» or means of giving up smoking? Comment to Article VD Mendelevich]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of contemporary clinical medicine]. 2015; 8 (3): 72-75.
5. Klinicheskie rekomendacii po lecheniju arterial’noj gipertonii ESH / ESC 2013 [Clinical guidelines for the treatment of hypertension, ESH / ESC 2013, Collection, 1st edition]. Moskva: Izdatel’stvo «Siliceja-Poligraf» [Moscow: Publishing house «Silitseya-Polygraph»]. 2014; 488 p.
6. Amirov NB, Galeeva ZM, Gornaeva LI, et al. Voprosy kliniki, diagnostiki, differencial’noj diagnostiki, lechenija i profilaktiki arterial’nyh gipertenzij [Questions clinic, diagnosis, differential diagnosis, treatment and prevention of arterial hypertension]. Kazan’: Medicina [Kazan: Medicine]. 2010; 128 p.
7. Prikaz № 104 MVD RT ot 19/02/2004 goda «O provedenii ezhegodnyh medicinskih osmotrov rukovodjashhih rabotnikov MVD, lichnogo sostava organov vnutrennih del, uchastnikov Velikoj Otechestvennoj Vojny i veteranov MVD» [Order № 104 of the Ministry of Internal Affairs 19/02/2004 «On holding of annual medical examinations of senior Interior Ministry employees, the personnel of the internal affairs bodies, participants of the Great Patriotic War and veterans of the Ministry of Interior»].
8. Prikaz № 895 MVD Rossii ot 30/11.2006 goda «Polozhenie ob organizacii medicinskogo obsluzhivanija i sanatorno-kurortnogo lechenija v medicinskih uchrezhdenijah sistemy MVD» [Order № 895 Russian Ministry of Internal Affairs of 30.11.2006 «Regulations on the organization of medical care and spa treatment in health facilities Ministry of Internal Affairs»].
9. Diagnostika i lechenie arterial’noj gipertonii: klinicheskie rekomendacii MZ RF [The diagnosis and treatment of hypertension: clinical guidelines MoH RF]. Moskva [Moscow]. 2013; URL: http://cardioweb.ru/klinicheskie-rekomendatsii
10. Diagnostika i lechenie arterial’noj gipertenzii: rossijskie rekomendacii (4 peresmotr) [Diagnosis and treatment of hypertension. Russian recommendations (revision 4)]. Moskva ]Moscow]. 2010; http://scardio.ru/content/Guidelines/recommendation-ag-2010.pdf
11. ESH/ESC. Rekomendacii po lecheniju arterial’noj gipertonii [Guidelines for the management of arterial hypertension]. 2013; http://www.scardio.ru/content/Guidelines/ESChypertension2013.pdf
THE IMPACT OF ADJUSTMENT DISORDER ON THE QUALITY OF LIFE OF POLICE OFFICERS
UDC 616.89-057.36(470.323)
DOI: 10.20969/VSKM.2016.9(6).95-99
SHIBAEV PAVEL V., psychiatrist, supervisor physician of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Kursk region, Russia, 305029, Kursk, Krasnyi Oktyabr str., 4, tel. 8-950-878-41-56, e-mail: schibaev.pavel@yandex.ru
Abstract. Aim. Clinical features of adjustment disorders and their impact on the quality of life of police officers returned from detached service in the North Caucasus region were studied. Material and methods. The study involved the officers of police department
of Kursk region. Patients were examined using clinical psychopathological method and psychometric tests before and after detached service. Results and discussion. Prolonged detached service was proved to be a stressful situation and a cause for adjustment disorders. It was found that the quality of life indicators of the patients with adjustment disorders are lower than in general population. Conclusion. It was shown that the negative effects of adjustment disorders on physical health, mental condition and social activity can be measured by the quality of life test. Changing the parameters of quality of life of patients with adjustment disorder is an essential part of the dynamics of their condition that must be considered when carrying out rehabilitation.
Key words: adjustment disorder, quality of life.
For reference: Shibaev PV. The impact of adjustment disorder on the quality of life of police officers. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 95—99.
References
1. Pogosov AV. Lechebno–profylakticheskye meropriyatiya dlya bolnyh posttravmaticheskimi stressovymi rasstroystvamy v sluchyah komorbidnosti [Therapeutic and prophylactic PTSD with comorbidity]. Naukovo–praktichnyi zhurnal Arhiv psihiatrii [The Scientific and practical archive of psychiatry]. 2004; 36: 17–21.
2. Ruggeri M, Warner R, Bisoffi G, Fontesedro L. Subjective and objective dimensions of quality of life in psychiatric patients: a factor analytical approach. British Journal of Psychiatry. 2001; 17: 268–275.
3. Evdokimov VI, Zaytceva DV, Fedotov AI. Nauchno–metodologicheskye problemy otcenki katchestva zhizni [Scientific and methodological problems of quality of life]. Vestnik psihiatrii [Journal of psychiatry]. 2008; 27: 102–131.
4. Zyikova AA, Potemina TE, Achremenko EV. Issledovanie katchestva zhizni pri narusheniyah dlitelnoy adaptatcii posle vozdeystviya boevogo stressa i travm [The research of quality of life with long–term adjustment disorders after combat stresses and traumas]. Vestnik novyh medicinskyx technology [Journal of modern medical technologies]. 2013; 20: 40–43.
5. Pogosov AV. Posttravmaticheskie stressovyie rasstroystva I komorbydnye sostoyanya u voennoslyzhaschyh (klinika, factory ryska, terapiya) [Military PTSD and comorbidity (clinic, triggers, therapy]. Kursk: KGMU. 2006; 268 p.
6. Svechnikov DV, Kurasov ES. Nevroticheskye adaptatcionnye rasstroystva v sovremennoy psihiatricheskoy praktike (analiz sostoyania problem) [Neurotic disorders of adaptation in modern psychiatric practice (state analysis of the problem)]. Vestnik natcionalnogo hirurgicheskogo centra im NI Pirogova [Bulletin of National Medical and Surgical Pirogov Center]. 2013; 8: 136–140.
7. Ichitovkina EG. Klinicheskye i socialno–psychologycheskye osobennosti kombatantov MVD pri vozdeystvii stress–faktorov boevoy obstanovki [Clinical and socio–psychological characteristics of the combatants of the Ministry of Internal Affairs under the influence of stress–factors of the combat situation]. Aftoreferat dissertacii kandidata medicinskih nauk [Extended abstract of PhD dissertation (Medicine)]. 2011; 24 p.
8. Casey Patricia R, Doherty Anne. Adjustment disorders: the state of the art. World Psychiatry. 2011; 10: 11–18.
CARDIOVASCULAR DESIESES IN INTERNAL AFFAIRS BODIES: FREQUENCY, JOB PERFORMANCE
UDC 616.12-057.36-036.22
DOI: 10.20969/VSKM.2016.9(6).99–103
SHOGENOV AKHMED G., C. Med. Sci., Head of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Kabardino-Balkar Republic, colonel of internal service, Russia, 360000, Nalchik, M. Gorky str., 7, tel. (8662)44-28-11, e-mail: mdo.kbr@list.ru
ELGAROV ANATOLY A., D. Med. Sci., professor, therapist of Clinic of the outpatient of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Kabardino-Balkar Republic, Russia, 360000, Nalchik, M. Gorky str., 7
MURTAZOV ALBERT M., C. Med. Sci., Head of the Center for psychophysiological diagnostics of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Kabardino-Balkar Republic, colonel of internal service, Russia, 360000, Nalchik, M. Gorky str., 7
Abstract. Aim. To establish the frequency of common cardiovascular diseases among internal affairs bodies as well as their job performance. Material and methods. Standardized epidemiological (n=1847) and clinical instrumental assessment of a 10% sample of random employees of internal service aged 25—53 years were recruited with the following daily monitoring of blood pressure (n=106) and electrocardiograms (n=75). Physiological testing was performed using chronoreflexometry complex apparatus — 01 (n=96). Results and discussion. Relatively high levels of the common risk factors (60–90%) and significant prevalence of arterial hypertension (39,3%), ischemic heart disease (18,8%) and heart rhythm disorders (17,9%), with a natural tendency to increase with age as well as the low awareness of the presence of predictors of acute cardiovascular disease and arterial hypertension (40,0%), ischemic heart disease (or 1,9%), cardiac arrhythmias (19,8 per cent) were found in police officers. Among persons with hypertension only 9,7% were on medication; constant rational antihypertensive therapy was rarely administered. Daily blood pressure monitoring in 70,5% of persons with stage I arterial hypertension demonstrated various deviations of the blood pressure profile: usually (67—72%) — in the evening/night and morning, rarely (28—33%) — day/evening or undifferentiated variants of hypertensive reactions. Morning rises in blood pressure were found in 79,1% of police officers with hypertension; significant deviations of basic parameters of professional performance in individuals with ischemic heart disease, arterial hypertension along with coronary disease Cerda with hypertension were defined via psycho-physiological testing. Conclusion. The frequency of arterial hypertension, coronary heart disease and heart rhythm disorders among police officers is high; thus the quality of their professional performance decreases. It requires early diagnosis and adequate correction. Presented results were the basis for creation of a data Bank Register of cardiovascular diseases, the use of which will enhance the management of psychosomatic status of internal Affairs bodies.
Key words: common cardiovascular diseases, epidemiology, policemen, professional workability.
For reference: Shogenov AG, Elgarov AA, Murtazov AM. Cardiovascular diseases in internal affairs bodies: frequency, job performance. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 99—103.
References
1. Izmerov NF. Aktualizacija voprosov professional’noj zabolevaemosti [Mainstreaming occupational diseases]. Zdravoohranenie RF [Healthcare of the Russian Federation]. 2013; 2: 14–17.
2. Izmerov NF, Buhtijarov IV, Prokopenko LV, Kuz’mina LP. Sberezhenie zdorov’ja rabotajushhih i prediktivno-preventivno-
personificirovannaja medicina [The Preservation of health and working of predictive-preventive and personalized medicine]. Medicina truda i promyshlennaja jekologija [Medicine of labour and industrial ecology]. 2013; 6: 7–12.
3. Sidorenko VA. Voenno-vrachebnaja jekspertiza v organah vnutrennih del Rossijskoj Federacii [The Military medical examination in internal Affairs agencies of the Russian Federation]. Medicinskij Vestnik MVD [Medical Journal of the Ministry of Interior]. 2016; 4: 2–4.
4. Shogenov AG, Murtazov AM. Psihosomaticheskie rasstrojstva u sotrudnikov special’nyh podrazdelenij organov vnutrennih del [Psychosomatic disorders of employees of special units of internal affair officers]. Medicina truda i promyshlennaja jekologija. [Occupational Medicine and industrial ecology]. 2007; 7: 10–13.
5. Shogenov AG. Upravlenie sostojaniem psihosomaticheskim statusa sotrudnikov pravoohranitel’nyh organov [Managing psychosomatic state of law enforcement officers]. Medicina truda i promyshlennaja jekologija [Occupational medicine and industrial ecology]. 2010; 11: 1–6.
6. Shogenova AB, Elgarov AA, Murtazov AM, Shogenov AG. Metabolicheskij sindrom i risk serdechno-sosudistyh zabolevanij u sotrudnikov pravoohranitel’nyh organov [Metabolic syndrome and the risk of cardiovascular diseases in employees of law enforcement agencies]. Medicina truda i promyshlennaja jekologija [Labor medicine and industrial ecology]. 2010; 11: 7–12.
7. Davhale R, Potapova MV, Amirov NB. Rasprostranennost’ arterial’noj gipertenzii sredi sotrudnikov pravoohranitel’nyh organov (Obzor literatury) [Prevalence of hypertension among law enforcement bodies (literature review)]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of contemporary clinical medicine]. 2013; 6 (2): 66–72.
8. Elgarov AA. Medicina truda opasnyh professij [Occupational medicine of dangerous occupations]. Medicina truda i promyshlennaja jekologija [Labor medicine and industrial ecology]. 2007; 5: 1–6.
9. Elgarov AA, Kalmykova MA, Elgarov MA. Arterial’naja gipertonija i aritmija serdca [Arterial hypertension and cardiac arrhythmias]. Nal’chik: OOO «Tetragraf» [Nalchik: Tetragraph]. 2011; 250 p.
10. Elgarov AA, Kalmykova MA, Elgarov AA. Otdel’nye neinfekcionnye zabolevanija sredi voditelej avtotransporta, bezopasnost’ dorozhnogo dvizhenija [Individual non–infectional diseases among vehicle drivers and road safety]. Nal’chik: Tetragraf [Nalchik: Tetragraph]. 2014; 232 p.
11. Amirov NB, Vizel AA, Potapova MV Ishkineev FI, Frolova EB, Merikova EF, Iskandarov VV, Afanasyev YA, Sokolov OR, Khusnutdinova RG. Chastota i osobennosti formirovanija gipertenzivnogo sindroma i faktorov riska SSZ u rabotnikov MVD i MChS, rabotajushhih v avtoinspekcii i pozharnoj sluzhbe [Frequency and characteristics of the formation of hypertensive syndrome and CVD risk factors among employees of the Interior Ministry and the Emergencies Ministry, working in the traffic police and the fire service]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Contemporary Clinical Medicine]. 2008; 1 (1): 93–95.
PNEUMOCOCCAL DISEASE PREVENTATIVE VACCINATION EXPERIENCE IN ORGANIZED GROUPS OF MILITARY OFFICERS
UDC [616.98:579.862.1]-057.36-084.47
DOI: 10.20969/VSKM.2016.9(6).103-108
SHUBIN IGOR V., C. Med. Sci., Honored doctor of the Russian Federation, Head of Clinical vaccinology laboratory of Scientific Research Institute of pulmonology, 105077, Moscow, 11th Parkovaya str., 32, build. 4, Chief therapist of Army medical department of Chief Command of interior troops of the Ministry of Internal Affairs of Russia, Russia, 111250, Moscow, Krasnokazarmennaya str., 9a, e-mail: shubin-igor@mail.ru
Abstract. The problem of pneumococcal disease is relevant not only in Russia but also worldwide. It acquires special relevance in organized groups of servicemen due to the impact of a number of adverse factors that accompany military service as well as the high density of people and therefore a high concentration of healthy individuals with nasopharyngeal carriage of pneumococcus in the group. Complex of these factors leads to an increase in the incidence of both non-invasive and invasive pneumococcal infections. Aim. Assessment of the effect of vaccination against respiratory infections in conscripts. Material and methods. Since 2002 in terms of medical protection against pneumococcal disease vaccination of conscripts using «Pnevmo-23» vaccine was performed. Results and discussion. Vaccination of the conscripts using «Pnevmo-23» vaccine has led to significant reduction of the incidence of community-acquired pneumonia as well as of severe and complicated forms of the disease. The greatest effect of the vaccination against respiratory infections has been achieved with simultaneous vaccination against influenza and pneumococcal disease providing high coverage. Conclusion. Preventative vaccination against pneumococcal disease in young people a few months prior military service can significantly reduce the number of military personnel suffering from pneumonia, which contributes to the preservation of their lives and health.
Key words: pneumococcus, pneumonia, vaccine, vaccination, military personnel.
For reference: Shubin IV. Pneumococcal disease preventative vaccination experience in organized groups of military officers. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 103—108.
References
1. Benja FM, Shevchuk PA, Rahcheev SV. Opyt immunoprofilaktiki vnebol’nichnoj pnevmonii v voinskih kollektivah [Experience the immunization community-acquired pneumonia in military units]. Voenno — medicinskii zhurnal [Military Medical Journal]. 2008; 12: 39-41.
2. Sabanin JuV, Rihter VV, Rybin VV et al. Specificheskaja profilaktika vnebol’nichnoj pnevmonii vo vnutrennih vojskah MVD Rossii [Specific prevention of community-acquired pneumonia in the internal troops of the Russian Interior Ministry]. Voenno — medicinskii zhurnal [Military Medical Journal]. 2008; 10: 31-34.
3. Sabanin JuV. Vakcinoprofilaktika aktual’nyh infekcij v sisteme protivojepidemicheskih meroprijatij vo vnutrennih vojskah MVD Rossii : dissertacija doktora medicinskih nauk [Vaccination of topical infections in the system of anti-epidemic measures in Internal Forces of Russia: the dissertation of the doctor of medical sciences]. Moskva [Moscow]. 2009; 283 p.
4. Gladinec IV, Ivashhenko AN, Rybin VV et al. O sovershenstvovanii profilaktiki ostryh boleznej organov dyhanija vo vnutrennih vojskah MVD Rossii [On improving the prevention of acute respiratory diseases in Internal Forces of Russia]. Medicinskii vestnik MVD [Medical Bulletin MIA]. 2014; 2 (69): 29-34.
5. Zhogolev SD, Ogarkov PI, Zhogolev PD et al. Jepidemiologija i profilaktika vnebol’nichnyh pnevmonij u voennosluzhashhih [Epidemiologiya and prevention of community-acquired pneumonia in the military]. Voenno — medicinskii zhurnal [Military Medical Journal]. 2013; 11: 55-60.
6. Rybin VV, Kas’kov OV, Jaroslavcev VV et al. Nekotorye jepidemiologicheskie aspekty boleznej organov dyhanija vo vnutrennih vojskah MVD Rossii [Some epidemiological aspects of respiratory diseases in the internal troops of the Russian Interior Ministry]. Voenno — medicinskii zhurnal [Military Medical Journal]. 2012; 7: 28-31.
7. Bajturov OR, Shubin IV. Nizkaja adaptacija voennosluzhashhih novogo popolnenija kak odin iz faktorov razvitija zabolevanij i simptomov, v chastnosti, dlitel’nogo subfebriliteta [Slow adaptation of servicemen of the new replenishment as one of the factors in the development of diseases and conditions, in particular, long subfebrile]. Medicinskii vestnik MVD [Medical Bulletin MIA]. 2014; LHVIII (1): 28-32.
8. Belevitin AB, Akimkin VG, Mosjagin VD et al. Organizacionno-jepidemiologicheskie aspekty profilaktiki vnebol’nichnoj pnevmonii v voinskih kollektivah [Orga nizational and epidemiological aspects of the prevention of community-acquired pneumonia in military units]. Voenno — medicinskii zhurnal [Military Medical Journal]. 2009; 9: 56-63.
9. Jaroslavcev VV, Sabanin JuV, Kas’kov OV et al. Vnebol’nichnaja pnevmonija u voennosluzhashhih vnutrennih vojsk MVD Rossii: osobennosti jepidemicheskogo processa [Community-acquired pneumonia in servicemen of internal troops of Russia: features of epidemic process]. Voenno — medicinskii zhurnal [Military Medical Journal]. 2011; 11: 40-43.
10. Rajcheva MV, Bilichenko TN, Shubin IV et al. Vlijanie novogo virusa grippa A (H1N1) na chastotu gospitalizacii po povodu pnevmonii v organizovannyh kollektivah [The impact of the new virus influenza A (H1N1) at the rate of hospitalization for pneumonia in organized groups]. Medicinskii vestnik MVD [Medical Bulletin MIA]. 2013; LHII (1): 57-61.
11. Rajcheva MV. Kliniko-jepidemiologicheskie osobennosti vnebol’nichnoj pnevmonii u molodyh muzhchin v organizovannyh kollektivah: dissertacija kandidata medicinskih nauk [Clinical and epidemiological features of community-acquired pneumonia in young men in organized groups: the dissertation of the candidate of medical sciences]. Moskva [Moscow]. 2015; 97 p.
12. Chuchalin AG, Shubin IV, Bashtovoj MA et al. Aktual’nye voprosy diagnostiki i lechenija grippa v pandemicheskij period (po materialam XIX-XX Nacional’nyh kongressov po boleznjam organov dyhanija) [ Current problems in the diagnosis and treatment of influenza in the pandemic period (based on xux-XX National Congress on respiratory diseases)]. Medicinskii vestnik MVD [Medical Bulletin MIA]. 2011; L (1): 13-17.
13. Shubin IV, Rajcheva MV, Bashtovoj MA, Chuchalin AG. Sovremennye podhody k diagnostike i lecheniju grippa v pandemicheskij period [Current approaches to diagnosis and treatment of influenza in the pandemic period]. Voenno — medicinskii zhurnal [Military Medical Journal]. 2010; 331 (4): 27-32.
14. Shubin IV, Chuchalin AG. Diagnostika i lechenie ostryh respiratornyh virusnyh infekcij, grippa i grippoznoj pnevmonii [Diagnosis and treatment of acute respiratory viral infections, influenza and influenza pneumonia]. Zhurnal «Poliklinika» [“Clinic” Magazine]. 2011; 2: 63-66.
15. Rajcheva MV, Shubin IV, Marsova LA [et al]. Jetiologicheskaja diagnostika vnebol’nichnoj pnevmonii u molodyh muzhchin v organizovannyh kollektivah s ispol’zovaniem testa «BinaxNOW®» [The etiological diagnosis of community-acquired pneumonia in young men in organized groups using a test “BinahNOSch®”]. Medicinskii vestnik MVD [Medical Bulletin MIA]. 2011; LI (2): 61.
16. Shubin IV, Budul JuI, Rajcheva MV et al. Metodicheskie ukazanija «Diagnostika, lechenie i profilaktika vnebol’nichnoj pnevmonii vo vnutrennih vojskah MVD Rossii » [Methodical guidelines “Diagnosis, treatment and prevention of community-acquired pneumonia in the Interior Troops of Russia]. Moskva: GKVV MVD Rossii [Moscow: Russian Ministry of Internal Affairs GKVV]. 2013; 2: 74 p.
URINARY TRACT INFECTIONS IN PREGNANCY: CURRENT RECOMMENDATIONS FOR DIAGNOSIS AND TREATMENT
UDC 618.3-06:616.6-022
DOI: 10.20969/VSKM.2016.9(6).109-114
ARKHIPOV EVGENY V., C. Med. Sci., assistant of professor of the Department of general practice of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. +7-843-231-21-39, e-mail: jekaland@mail.ru
SIGITOVA OLGA N., D. Med. Sci., professor, Head of the Department of general practice of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. +7-843-231-21-39, e-mail: osigit@rambler.ru
Abstract. Aim. To analyze the current data on the issue of diagnosis, classification and treatment of urinary tract infections in pregnancy. Material and methods. The publications of native and foreign authors as well as the data from randomized clinical and epidemiological studies were reviewed. Results and discussion. Modern classification, approaches to diagnosis and tactics of antimicrobial therapy of urinary tract infections in pregnancy are present in the article from the position of evidence based medicine, which should be the guide for practitioners engaged in management and treatment of these patients. Conclusion. The use of modern methods of diagnosis and rational therapy of urinary tract infections in pregnancy can significantly reduce the risk of one’s recurrence as well as the complications of pregnancy, with a real ability to fully achieve both clinical and microbiological convalescence.
Key words: pyelonephritis, urinary tract infection, diagnosis, pregnancy, antibacterial therapy.
For reference: Arkhipov EV, Sigitova ON. Urinary tract infections in pregnancy: current recommendations for diagnosis and treatment. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 109—114.
References
1. Nicolle L, Bradley S, Colgan R et al. Infectious Diseases Society of America guidelines for the diagnosis and treatment of asymptomatic bacteriuria in adults. Clin Infect Dis. 2005; 40: 643-654.
2. Gilstrap LC, Ramin SM. Urinary tract infections during pregnancy. Obstet Gynecol Clin North Am. 2001; 28: 581-591.
3. Wing DA, Fassett MJ, Getahun D. Acute pyelonephritis in pregnancy: an 18-year retrospective analysis. Am J Obstet Gynecol. 2014; 210 (3): 219.
4. Hill JB, Sheffield JS, McIntire DD et al. Acute pyelonephritis in pregnancy. Obstet Gynecol. 2005; 105: 18-23.
5. Farkash E, Weintraub AY, Sergienko R et al. Acute antepartum pyelonephritis in pregnancy: a critical analysis of risk factors and outcomes. Eur J Obstet Gynecol Reprod Biol. 2012; 162 (1): 24-27.
6. Smaill F, Vazquez JC. Antibiotics for asymptomatic bacteriuria in pregnancy. Сochrane Database System Review. 2007; (2): CD000490.
7. Palagin IS, Suhorukova MV, Dehnich AV et al. Sovremennoe sostojanie antibiotikorezistentnosti vozbuditelej vnebol’nichnyh infekcij mochevyh putej v Rossii: rezul’taty issledovanija «DARMIS» (2010–2011) [Current status of antibiotic resistance of pathogens of community-acquired urinary tract infections in Russia: Results of the study «DARMIS» (2010-2011)]. Klinicheskaja mikrobiologija i antimikrobnaja himioterapija [Clinical Microbiology and Antimicrobial Chemotherapy]. 2012; 14 (4): 280-303.
8. Perepanova TS, Kozlov RS, Rudnov VA, Sinjakova LA. Antimikrobnaja terapija i profilaktika infekcij pochek, mochevyvodjashhih putej i muzhskih polovyh organov: rossijskie nacional’nye rekomendacii [Antimicrobial therapy and prevention of infections of the kidneys, urinary tract and male reproductive organs: russian national guidelines]. Moskva [Moscow]: Prima-print. 2013; 64 р.
9. Rafal’skij VV. Antibakterial’naja terapija ostroj gnojnoj infekcii pochek [Antibiotic therapy of acute purulent infection of the kidneys]. Consilium Medicum. 2006; 8 (4): 5-8.
10. Lifshitz E, Kramer L. Outpatient urine culture: does collection technique matter? Arch Intern Med. 2000; 160 (16): 2537-2540.
11. Grabe M, Bjerklund-Johansen T, Botto H et al. EAU: Guidelines on urological infections: European Association of Urology Guidelines. European Association of Urology. 2014; 108 p.
12. Millar LK, Wing DA, Paul RH et al. Outpatient treatment of pyelonephritis in pregnancy: a randomized controlled trial. Obstet Gynecol. 1995; 86 (4 Pt 1): 560-564.
13. Vazquez JC, Villar J. Treatments for symptomatic urinary tract infections during pregnancy. Cochrane Database System Review. 2000; (3): CD002256.
14. Wing DA, Park AS, Debuque L et al. Limited clinical utility of blood and urine cultures in the treatment of acute pyelonephritis during pregnancy. Am J Obstet Gynecol. 2000; 182 (6): 1437-1440.
15. Schaeffer AJ, Schaeffer EM. Infections of the urinary tract. Cambell-Walsh urology: 10th edition, editor Wein AJ. Philadelphia: Saunders, an imprint of Elsevier Inc. 2012; 257-326.
16. Pfau A, Sacks TG. Effective prophylaxis for recurrent urinary tract infections during pregnancy. Clin Infect Dis. 1992; 14 (4): 810-814.
17. Naber K, Steindl H, Abramov-Sommariva D, Eskoetter H. Non-antibiotic herbal therapy of uncomplicated lover urinary tract infection in wamen — a pilot study: planta medica. J Med Plant Nat Prod Res. 2013; 79: 1079-1288.
GAIT DISORDERS IN THE ELDERLY: DIAGNOSIS AND COMPLEX REHABILITATION
UDC 616.8-009.18-053.9(048.8)
DOI: 10.20969/VSKM.2016.9(6).115-119
BAYBULATOVA LILIYA F., Head of the Department of rehabilitationof of Clinical hospital of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, Russia, Kazan, 420048, Orenburgsky trakt str., 132, tel. +7-917-286-80-31, e-mail: liliya-bajbulatova@yandex.ru
ZAKIROVA DILYRA R., Head of the Department of neurology of Clinical hospital of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, Russia, Kazan, 420048, Orenburgsky trakt str., 132, tel. +7-987-066-73-08, e-mail: dilyara.zakirova555@yandex.ru
MAMEDOV KHALIT I., Head of the Department of stroke unit of Republic Clinical Hospital, Russia, Kazan, 420048, Orenburgsky trakt str., 138, tel. +7-905-314-35-66, e-mail: mamedov1961@yandex.ru
KHUZINA GULNARA R., C. Med. Sci., associate professor of the Department of neurology and rehabilitation of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. +7-987-296-43-86, e-mail: gkhuzina@yandex.ru
Abstract. Gait disorders and postural instability is observed in 80—90% of the elderly population. It is one of the most important factors that determine the quality of life deterioration as well as increased morbidity and mortality. Aim. To analyze the modern principles of complex rehabilitation of gait disorders. Material and methods. Analysis of native and foreign literature was performed. Results and discussion. Dangerous consequences of movement disorders in the elderly are falls, tending to end up with fractures in 5—10% of cases, as well as the head injuries, soft tissue injuries and avulsed wounds in up to 36% of cases. Falls are on the sixth place among the mortality causes in older people. They are the reason for 40% of nursing homes assignments. Very often falls turn into phobias — «a fear of falling syndrome». Patients having these phobias stop moving or getting out of the bed. The fear of recurrent falls significantly limits potential social life. Conclusion. Movement and balance disorders in the elderly are a complex and important problem. The solution is the complex medical and social support measures starting from diagnostic and therapeutic expertise ending with rehabilitation and adaptation.
Key words: gait disorders, ataxia, coordination disorders, abnormal walking patterns, rehabilitation, postural control.
For reference: Baybulatova LF, Zakirova DR, Mamedov HI, Huzina GR. Gait disorders in the elderly: diagnosis and complex rehabilitation. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 115—119.
References
1. Nutt JG, Marsden CD, Thompson PD. Human walking and higher-level gait disorders, particularly in the elderly. Neurology. 1993; 43: 268-79.
2. Huber-Mahlin V, Giladi N, Herman T et al. Progressive nature of a higher level gait disorder: a 3-year prospective study. J Neurol. 2010; 257 (8): 1279-1286.
3. Gillespie LD, Gillespie WJ, Robertson MC et al. Interventions for preventing falls in elderly people. Cochrane Database Syst Rev. 2009; 15 (2): CD000340.
4. Giladi N, Herman T, Reider-Groswasser II et al. Clinical characteristics of elderly patients with a cautious gait of unknown origin. J Neurol. 2005; 252: 300-306.
5. Axer H, Axer M, Sauer H, Witte OW, Hagemann G. Falls and gait disorders in geriatric neurology. Clin Neurol Neurosurg. 2010; 112: 265-274.
6. Marquis S, Moore MM, Howieson DB et al. Independent predictors of cognitive decline in healthy elderly persons. Arch Neurol. 2002; 59: 601-606.
7. Berg K, Wood-Dauphinee S, Williams JI, Maki B. Measuring balance in the elderly: Validation of an instrument. Can J Pub Health. 1992; 83 (2): 7-11.
8. Giladi N. Freezing of gait: clinical overview. Adv Neurol. 2001; 87: 191-197.
9. Lundin-Olsson L, Nyberg L, Gustafson Y. «Stops walking when talking» as a predictor of falls in elderly people. Lancet. 1997; 349: 617.
10. Gillespie LD, Robertson MC, Gillespie WJ et al. Interventions for preventing falls in older people living in the community. Cochrane Database Syst Rev. 2012; 12 (9): CD007146.
11. Morton SM, Bastian AJ. Cerebellar control of balance and locomotion. Neuroscientist. 2004; 10: 247-259.
12. Springer S, Giladi N, Peretz C et al. Dual-tasking effects on gait variability: the role of aging, falls, and executive function. Mov Disord. 2006; 21: 950-957.
13. Kogan OG, Najdin VL. Medicinskaja reabilitacija v nevrologii i nejro-hirurgii. [Medical rehabilitation in neurology and neuro-surgery]. Moskva: Medicina [Moscow: Medicine]. 1988; 304 р.
14. Holden MK, Gill KM et al. Clinical gait assessment in the neurologically impaired: reliability and meaningfulness. Phys Ther. 1984; 64 (1): 35-40.
15. Ioffe ME, Ustinova KI, Chernikova LA et al. Osobennosti obucheniju proizvol’nomu kontrolju pozy pri porazhenijah piramidnoj i nigrostriarnoj sistem [Features of training to arbitrary control posture in lesions of the pyramidal and the nigrostriatal system]. Zhurnal vysshej nervnoj dejatel’nosti [Journal of higher nervous activity]. 2003; 3: 306-312.
16. Jorstad EC, Hauer K, Becker C, Lamb SE. Measuring the psychological outcomes of falling: a systematic review. J Am Geriatr Soc. 2005; 53: 501-510.
PAROXYSMAL MOVEMENT DISORDERS AS AN INTERDISCIPLINARY PROBLEM: PRINCIPLES OF DIAGNOSIS AND THERAPY
UDC 616.831-009-039.31(048.8)
DOI: 10.20969/VSKM.2016.9(6).119-124
ZAKIROVA DILYARA R., Head of the Department of neurology of Clinical hospital of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, Russia, 420048, Kazan, Orenburgsky trakt str., 132, tel. +7-987-066-73-08, e-mail: dilyara.zakirova555@yandex.ru
SITDIKOVA ALINA I., physician of Military physician board of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, Russia, 420048, Kazan, Orenburgsky trakt str., 132, tel. +7-965-582-57-17, e-mail: alinochka_636@mail.ru
IKSANOVA EKATERINA N., neurologist of the Department of neurology of Clinical hospital of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, Russia, 420048, Kazan, Orenburgsky trakt str., 132, tel. +7-906-116-24-21, e-mail: iksanova_en@mail.ru
KHUZINA GULNARA R., C. Med. Sci., associate professor of the Department of neurology and rehabilitation of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. +7-987-296-43-86, e-mail: gkhuzina@yandex.ru
Abstract. Aim. This paper illustrates the current state of the problem and the principles of differential diagnosis of paroxysmal movement disorders. Material and methods. Paroxysmal movement disorders are one of the most important problems of modern clinical medicine characterized by steady increase of these conditions in young and middle-aged people as well as by diagnostic complexity of majority of conditions. Analysis of the current and relevant publications, data and personal observations on this issue were taken in consideration. Results and discussion. About 30% of the adult population has experienced at least one cerebral paroxysm (CPU). Approximately 42—57% of all traffic accidents were caused by impaired consciousness of various origins in drivers. In children CPU occurs 5—10 times more often than in adults, coming to 60% during the first 3 years of life (Aslanov, L.M., 1990). In general the frequency of convulsive seizures in children reaches 14% of the total number in the population (Kreindler A. et al., 2003). Conclusion.Тhe etiology of paroxysmal disorders is very diverse. The origin of the attacks can be either primary cerebral or secondary due to a number of somatic and metabolic diseases. Multiple etiologies are often the reason for the difficult differential diagnosis as well as for error-prone management of patients. Diagnosis of paroxysmal disorders is a complex and urgent problem where solution comes after the set of clinical diagnostic activities of interdisciplinary character.
Key words: paroxysmal disorders, cerebral paroxysm, syncope, paroxysmal movement disorders.
For reference: Zakirova DR, Sitdicova AI, Iksanova EN, Huzina GR. Paroxysmal movement disorders as an interdisciplinary problem: principles of diagnosis and therapy. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 119—124.
References
1. Karlov VA. Paroksizmal’nye sostojanija v nevrologicheskoj klinike: definicii, klassifikacija, obshhie mehanizmy patogeneza. [Paroxysmal States in the neurological clinic: definitions, classification, General mechanisms of pathogenesis]. Moskva [Moscow]: AO «Buklet». 1995; 397 p.
2. Donaldson JO. Neurology of Pregnancy. Philadelphia: Saunders. 1978; 211—250.
3. Abramovich GB, Taganov IN. O znachimosti razlichnyh patogennyh faktorov v proishozhdenii epilepsii u detej i podrostkov [On the significance of various pathogenic factors in the origin of epilepsy in children and adolescents]. Zhurnal nevrologii i psihiatrii [Journal of Neurology and Psychiatry]. 1969; 69: 553-565.
4. Boldyrev AI. Jepilepsija u detej i podrostkov [Epilepsy in children and adolescents]. Moskva: Medicina [Moscow: Medicine]. 1990; 318 р.
5. Porter RJ, Morselli PL eds. The Epilepsies. Boston: Butterworth. 1985; 396 p.
6. Iivanainen M. Diagnosing epilepsy in patients with mental retardation. Epilepsy and mental retardation. Biddles Ltd, Guildford. 1999; 47-60.
7. Leontieva IV, Таrаsоvа АV, Тutеlman КМ. Mehanismi i kriterii diagnostiki sincopalnih sostoiynii u ndetei [Mechanisms and criteria for diagnosis of syncope inchildren]. Sоvrеmеnniee tеhnоlоgii v pеdiаtrii i detskоiy hirurgii [Modern technologies in Pediatrics and children’s surgery]. 2003; 196.
8. Akimov GA, Erohina LG, Stykan OA. Nevrologija sinkopal’nyh sostojanij [Neurology of syncope]. Moskva: Medicina [Moscow: Medicine]. 1987; 207 р.
9. Solomon GE, Kutt H, Plum F. Clinical Management of Seizures (2nd ed.). Philadelphia: Saunders. 1983; 320 p.
10. Browne TR, Feldman RL. Epilepsy: Diagnosis and Management. Boston: Little, Brown. 1983; 233-245.
11. Belоusоvа ЕD, Еrmаkоvа АU. Differencialniy diagnos epilepsii [The differential diagnosis of epilepsy]. Мoskva: Puls [ Moscow: Pulse]. 2007; 363 р.
12. Muhin КU, Petruhin АS, Мironov МB. Epilepticheskie sindromiy: diagnostika i terapia [Epileptic syndromes: diagnosis and therapy]. Мoskva: Sistemnye reshenija [Moscow: System solutions]. 2008; 223 р.
13. Каrlov VА. Epilepsia u deteiy i vzroslich, jenchin i mujchin [Epilepsy in children and adults, women and men]. Moskva: Medicina [Moscow: Medicine]. 2010; 720 p.
THE FEATURES OF CRITICAL CONDITION POLINEUROMYOPATHY TREATMENT
UDC [616.74+616.833]-039.31-08(048.8)
DOI: 10.20969/VSKM.2016.9(6).124-130
SAKOVETS TATIANA G., C. Med. Sci., assistant of professor of the Department of neurology and rehabilitation of Kazan
State Medical University, Russia, 420012, Kazan, Butlerov str., 49, e-mail: tsakovets@yandex.ru
SITDIKOVA ALINA I., physician of Military physician board of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, Russia, 420111, Kazan, Lobachevsky str., 9, tel. +7-965-582-57-17, e-mail: alinochka_636@mail.ru
BOGDANOV ENVER I., D. Med. Sci., Head of the Department of neurology and rehabilitation of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. +7-843-237-34-72, e-mail: enver_bogdanov@mail.ru.
KHUZINA GULNARA R., C. Med. Sci., associate professor of the Department of neurology and rehabilitation of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, e-mail: gkhuzina@yandex.ru
Abstract. Aim. This paper presents the current state of the problem and the principles of critical condition мyopathy/polyneuropathy differential diagnosis. Critical condition myopathy/polyneuropathy is a syndrome characterized by neuromuscular disorders in intensive care unit patients presenting myopathy and/or sensory-motor neuropathy of progressive nature, following sepsis, multiple organ failure, acute distress syndrome or heart or urinary-genital system пациsurgery. Material and methods. Analysis of the current and relevant publications, data and personal observations on this topic was performed. Results and discussion. Classification of neuro-muscular disorders in intensive care units includes critical condition polyneuropathy, prolonged neuromuscular block and critical condition myopathy. In terms of risk factor development in critical condition myopathy/polyneuropathy older age, female gender, hypoxia and hypotension, hyperthermia, hyperglycemia, hypoalbuminemia, treatment with corticosteroids or aminoglycosides should be considered. Critical condition myopathy/polyneuropathy affects every day household activity and reduces the quality of life. It determines the need for early rehabilitation. Conclusion. In order to maximize effectiveness of rehabilitative treatment it requires continuity in rehabilitation process organization. The patient needs to continue rehabilitation in outpatient clinic. In order to avoid polyneuromyopathy it is necessary to provide adequate treatment to prevent sepsis, systemic inflammation or multiple organ failure. Effective treatment for critical condition myopathy/polyneuropathy requires multidisciplinary approach.
Key words: critical condition polyneuropathy, intensive care, rehabilitation treatment for critical condition polyneuropathy.
For reference: Sakovets TG, Sitdikova AI, Bogdanov EI, Huzina GR. The features of critical condition polineuromyopathy treatment. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 124—130.
References
1. Hermans G, De Jonghe B, Bruyninckx F, Van den Berghe G. Interventions for preventing critical illness polyneuropathy and critical illness myopathy. Cochrane Database Syst Rev. 2014; 10.1002/14651858.CD006832.pub3.
2. Bercker S, Weber-Carstens S, Deja M et al. Critical illness polyneuropathy and myopathy in patients with acute respiratory distress syndrome. 2005; 33 (4): 711-715.
3. Alhan HC, Cakalağaoğlu C, Hanci M et al. Critical-illness polyneuropathy complicating cardiac operation. Ann Thorac Surg. 1996; 61 (4): 1237-1239.
4. Li H, Wu LM, Kong XB et al. Reversible tetraplegia after percutaneous nephrostolithoto -and septic shock: a case of critical illness polyneuropathy and myopathy with acute onset and complete recovery. BMC Nephrol. 2013; 4: 36.
5. Guarneri B, Bertolini G, Latronico N. Long-termoutcome in patientswith critical illness myopathy or neuropathy: the Italian multicentre CRIMYNE study. J Neurol Neurosurg Psychiatry. 2008; 79: 838-841.
6. Lacomis D. Neuromuscular disorders in critically ill patients: review and update. J Clin Neuromuscul Dis. 2011; 12 (4): 197-218.
7. De Jonghe B, Lacherade JC, Durand MC. Critical illness neuromuscular syndromes. Neurol Clin. 2008; 26: 507-520.
8. Appleton RT, Kinsella J, Quasim T. The incidence of intensive care unit-acquired weakness syndromes: A systematic review. J Intensive Care Soc. 2014; doi:10.1177/1751143714563016
9. Hough CL, Lieu BL, Caldwell Ellen S. Manual muscle strength testing of critically ill patients: feasibility and interobserver agreement. Crit Care. 2011; 15: 43.
10. De Jonghe B, Sharshar T, Lefaucheur JP et al. Paresis acquired in the intensive care unit: a prospective multicenter study. JAMA. 2002; 288: 2859-2867.
11. De Seze M, Petit H, Wiart L et al. Critical illness polyneuropathy; a 2-year followup study in 19 severe cases. Eur Neurol. 2000; 43: 61–69.
12. Latronico N, Guarneri B. Critical illness myopathy and neuropathy. Minerva Anestesiol. 2008; 74: 319-323.
13. Koch S, Wollersheim T, Bierbrauer J et al. Long-term recovery in critical illness myopathy is complete, contrary to polyneuropathy. Muscle Nerve. 2014; 50: 431-436.
14. Bolton CF. Neuromuscular manifestation of critical illness. Muscle nerves. 2005; 32: 140-163.
15. Maxwell SD, Hilton-Jones D. Neuromuscular disorders in the intensive care unit in: NT Rabi, V Shannon (Eds.). Neuromuscular Disorders, First ed John Wiley & Sons. 2011; 247-248.
16. Zhou C, Wu L, Ni F et al. Critical illness polyneuropathy and myopathy: a systematic review. Neural Regen Res. 2014; 9 (1): 101-110.
17. Celik C, Ucan H, Alemdaroglu E et al. Critical illness polyneuropathy: a case report. Neuro Rehabilitation. 2011; 29 (3): 229-232.
18. Chen HY, Chen HC et al. Bilateral diaphragmatic paralysis in a patient with critical illness polyneuropathy: a case report. Medicine (Baltimore). 2015; 94 (31): 1288.
19. Gosselink R, Bott J, Johnson M et al. Physiotherapy for adult patients with critical illness: recommendations of the European respiratory society and European society of intensive care medicine task force on physiotherapy for critically ill patients. Intensive Care Med. 2008; 34 (7): 1188–1199.
20. Pati S, Goodfellow JA, Iyadurai S et al. Approach to critical illness polyneuropathy and myopathy. Postgrad Med J. 2008; 4 (993): 354-360.
21. Banwell BL. Muscle weakness in critically ill children. Neurology. 2003; 61: 1779–1782.
22. Voitenkov VB, Vilnits AA, Klimkin AV. Klinicheskie I neurofiziologicheskie osobennosti polinevripatii kriticheskih sostojanii u detei s infektsionimi zabolevaniami [Clinical and neurophysiological features of polyneuropathy of critical conditions in children with infectious diseases]. Medicina ekstremalniih cituacii [Medicine extreme situations]. 2015; 2: 33-37.
23. Kukreti V, Shamim M, Khilnani P. Intensive care unit acquired weakness in children: Critical illness polyneuropathy and myopathy. Indian J Crit Care Med. 2014; 18 (2): 95-101.
24. Ponfick M, Linden R, Nowak DA. Dysphagia: a common, transient symptom in critical illness polyneuropathy: a fiberoptic endoscopic evaluation of swallowing study. Crit Care Med. 2015; 43 (2): 365-372.
25. Reitz A. Lower urinary tract dysfunction in critical illness polyneuropathy. Neuro Rehabilitation. 2013; 33 (2): 329-336.
26. De Visser M, Tjärnlund A, Bottaic M et al. Progress report on the development of new classification criteria for adult and juvenile idiopathic inflammatory myopathies. Journal of the Neurological Sciences. 2013; 333: 422-480.
27. Kalamgi RC, Larsson L. Mechanical signaling in the pathophysiology of critical illness myopathy. Front Physiol. 2016; 7: 23.
28. Kondratiev SA, Zabrodskaja UM, Razmologova OU. Patomorfologicheskie osobennosti polineuropatii criticheskih sostojanii u pacientov v persistirujeschem vegetativnom sostojanii I sostojanii “malogo coznania» [Pathological features polineyromiopatii critical states of patients in persistent vegetative state, and a state of «small mind»]. Rossijskij nejrohirurgicheskij zhurnal imeni Polenova AL [Russian Journal of Neurosurgery named after Polenov AL]. 2013; 5 (4): 46-51.
29. Khilnani GC, Bansal R. Neuromuscular weakness in critically ill. Japi. 2004; 52: 131–136.
30. Van Mook W, Huliseiv´e-Evers R. Critical illness polyneuropathy. Curr Opin Crit Care. 2002; 8: 302-310.
31. Kennedy DD, Coakley J, Griffiths RD. Neuromuscular problems and physical weakness: in: Griffiths RD, Jones C, editors; Intensive care after care. Oxford: Butterworth–Heinemann. 2002; 1: 7-18.
32. Sanap MN, Worthley LIG. Neurologic complications of critical illness; part II: polyneuropathies and myopathies. Crit Care Resusc. 2002; 4: 133-140.
33. Latronico N, Bertolini G, Guarneri B et al. Simplified electrophysiological evaluation of peripheral nerves in critically ill patients: the Italian multi-centre CRIMYNE study. Crit Care. 2007; 11: 11.
34. Khilnani GC, Bansal R, Malhotra OP et al. Case report: critical illness polyneuropathy: how often do we diagnose it? Indian J Chest Dis Allied Sci. 2003; 45: 209-213.
35. The LN, Huub CN. Critical illness polyneuropathy and myopathy in a rural area in Vietnam. Journal of the Neurological Sciences. 2015; 357: 276-281.
36. Mikaeili H, Yazdchi M, Barazandeh F et al. Euglycemic state reduces the incidence of critical illness polyneuropathy and duration of ventilator dependency in medical intensive care unit. Bratisl Lek Listy. 2012; 13 (10): 616-619.
37. Gurjar M, Azim A, Baronia AK et al. Facial nerve involvement in critical illness polyneuropathy. Indian J Anaesth. 2010; 54 (5): 472-474.
38. Confer J, Wolcott J, Hayes R. Critical illness polyneuromyopathy. Am J Health Syst Pharm. 2012; 69 (14): 1199-1205.
39. Chawla J, Gruener G. Management of critical illness polyneuropathy and myopathy. J Chawla. 2010; 28: 961-977.
40. Fletcher S, Kennedy D, Ghosh I et al. Persistent neuromuscular and neurophysiologic abnormalities in long-term survivors of prolonged critical illness. Crit Care Med. 2003; 31: 1012–1016.
41. Van den Berghe G, Wouters P, Weekers F et al. Intensive insulin therapy in the critically ill patients. N Engl J Med. 2001; 345: 1359–1367.
42. Van den Berghe G, Wilmer A, Hermans G et al. Intensive insulin therapy in the medical ICU. N Engl J Med. 2006; 354 (5): 449-461.
43. Pichard C, Kyle U, Chevrolet JC et al. Lack of effects of recombinant growth hormone on muscle function in patients requiring prolonged mechanical ventilation: a prospective, randomized, controlled study. Crit Care Med. 1996; 24: 403-413.
44. Spies CD, Reinhart K, Witt I et al. Influence of N-acetylcysteine on indirect indicators of tissue oxygenation in septic shock patients: results from a prospective, randomized, double-blind study. Crit Care Med. 1994; 22: 1738-1746.
45. Mohr M, Englisch L, Roth A et al. Effects of early treatment with immunoglobulin on critical illness polyneuropathy following multiple organ failure and gram-negative sepsis. Intensive Care Med. 1997; 23: 1144–1149.
46. Brunner R, Rinner W, Haberler C et al. Еarly treatment with IgM-enriched intravenous immunoglobulin does not mitigate critical illness polyneuropathy and/or myopathy in patients with multiple organ failure and SIRS/sepsis: a prospective, randomized, placebo-controlled, double-blinded trial. 2013; 17 (5): 213.
47. Mehrholz J, Pohl M, Kugler J, Burridge J, Mückel S, Elsner B. Cochrane Database Syst Rev. 2015; 3: CD010942.
UDC 616.611-002(048.8)
DOI: 10.20969/VSKM.2016.9(6).130-137
SIGITOVA OLGA N., D. Med. Sci., professor, Head of the Department of general practice of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. (843) 231-21-39, e-mail: osigit@rambler.ru
KIM TAISYA YU., postgraduate student of the Department of general practice of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. (843) 231-21-39, e-mail: tais_ariana@mail.ru
Abstract. Aim. Analysis and presentation of the current guidelines for diagnosis, immunosuppressive and syndrome treatment, prevention of relapse of glomerulonephritis both at outpatient and hospital stage, the use of which would improve disease prognosis and delay its progression. Material and methods. Clinical review of scientific publications, results of native and foreign basic and clinical research relying on evidence-based medicine. Results and discussion. The recommendations allow estimating diagnosis timely, differentiating active and supportive immunosuppressive therapy and syndrome treatment as well as developing individual tactics of treatment of glomerulonephritis at outpatient and hospital stage. They allow to achieve clinical and laboratory remission and to reduce the frequency of relapses of glomerulonephritis. Conclusion. Application of the guidelines in clinical practice will contribute to the early diagnosis of glomerulonephritis and to increase the efficiency of treatment and prevention, which will delay the progression of the disease and improve the prognosis. Key words: glomerulonephritis, diagnosis, treatment, relapse prevention, evidence-based medicine.
For reference: Sigitova ON, Kim TYu. Guidelines for diagnosis, treatment and prevention of recurrence of glomerulonephritis at the outpatient and hospital stage. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 130—137.
References
1. Tareeva IE ed. Glomerulonefrity: nefrologija — rukovodstvo dlja vrachej [Glomerulonephritis: nephrology — guidelines for doctors]. Moskva: Medicina [Moscow: Medicine]. 2000: 188-279.
2. Muhin NA ed. Nefrologija, nacional’noe rukovodstvo [Nephrology, national guide]. Moskva: GJeOTAR-Media [Moscow: GEOTAR- Media]. 2009; 45 p.
3. Tiebosch AT, Frederik PM, van Breda Vriesman PJ, Mooy JM, van Rie H, van de Wiel TW, et al. Thin-basement-membrane nephropathy in adults with persistent hematuria. N Engl J Med. 1989; 320: 14-18.
4. Haas M. Histologic subclassification of IgA nephropathy: A clinicopathologic study of 244 cases. Am J Kidney Dis. 1997; 29: 829-842.
5. Rekola S, Bergstrand A, Bucht H. Deterioration of GFR in IgA nephropathy as measured by 51Cr-EDTA clearance. Kidney Int. 1991; 40: 1050-1054.
6. Lai KN, Li PK, Lui SF, Au TC, Tam JS, Tong KL et al. Membranous nephropathy related to hepatitis B virus in adults. N Engl J Med. 1991; 324: 1457-1463.
7. Pinto SW, Sesso R, Vasconcelos E, Watanabe YJ, Pansute AM. Follow-up of patients with epidemic poststreptococcal glomerulonephritis. Am J Kidney Dis. 2001; 38 (2): 249-255.
8. Hall CL, Jawad S, Harrison PR, MacKenzie JC, Bacon PA, Klouda PT, MacIver AG. Natural course of penicillamine nephropathy: A long-term study of 33 patients. Br Med J. 1988; 296 (6629): 1083-1086.
9. Hall CL, Fothergill NJ, Blackwell MM, Harrison PR, MacKenzie JC, MacIver AG. The natural course of gold nephropathy:
Long term study of 21 patients. Br Med J. 1987; 295 (6601): 745-748.
10. Verroust PJ. Kinetics of immune deposits in membranous nephropathy. Kidney Int. 1989; 35 (6): 1418-1428.
11. Schena FP, Cameron JS. Treatment of proteinuric glomerulonephritides in adults. Am J Med. 1988; 85: 315-326.
12. Trachtman H, Weiss RA, Bennett B, Griefer I. Isolated hematuria in children: Indications for a renal biopsy. Kidney Int. 1984; 25 (1): 94-99.
13. Tareeva IE ed. Pochki pri sistemnyh zabolevanijah: nefrologija — rukovodstvo dlja vrachej [The kidneys in systemic diseases: nephrology — guidelines for doctors]. Moskva: Medicina [Moscow: Medicine]; 2000: 280-320.
14. Auwardt R, Savige J, Wilson D. A comparison of the clinical and laboratory features of thin basement membrane disease (TBMD) and IgA glomerulonephritis. Clin Nephrol. 1999; 52 (1): 1–4.
15. Blumenthal SS, Fritsche C, Lemann JJr. Establishing the diagnosis of benign familial hematuria. The importance of examining the urine sediment of family members. JAMA. 1988; 259 (15): 2263-2266.
16. Flinter FA, Cameron JS, Chantler C, Houston I, Bobrow M. Genetics of classic Alport’s syndrome. Lancet. 1988; 2 (8618): 1005–1007.
17. Hudson BG, Tryggvason K, Sundaramoorthy M, Neilson EG. Alport’s syndrome, Goodpasture’s syndrome, and type IV collagen. N Engl J Med. 2003; 348: 2543-2556.
18. Johnston PA, Brown JS, Braumholtz DA, Davison AM. Clinico-pathological correlations and long-term follow-up in 253 United Kingdom patients with IgA nephropathy: A report from the MRC glomerulonephritis registry. Q J Med. 1992; 84 (304): 619-627.
19. Julian BA, Quiggins PA, Thompson JS, Woodford SY, Gleason K, Wyatt RJ. Familial IgA nephropathy. Evidence of an inherited mechanism of disease. N Engl J Med. 1985; 312 (4): 202-208.
20. Kashtan CE. Alport syndrome and thin glomerular basement membrane disease. J Am Soc Nephrol. 1998; 9: 1736-1750.
21. Tiebosch AT, Wolters J, Frederik PF, van der Wiel TW, Zeppenfeldt E, van Breda Vriesman PJ. Epidemiology of idiopathic glomerular diseases: a prospective study. Kidney Int. 1987; 32 (1): 112-116.
22. Abe S. Pregnancy in IgA nephropathy. Kidney Int. 1991; 40: 1098-1102.
23. Kidney Disease: Improving Global Outcomes (KDIGO) Glomerulonephritis Work Group. KDIGO Clinical Practice Guideline for Glomerulonephritis. 2012; 2: 139-274.
24. Tamura S, Masuda Y, Inokuchi I, Terasawa K, Sugiyama N. Effect of and indication for tonsillectomy in Ig A nephropathy .Acta Otolaryngol Suppl. 1993; 508: 23-28.
25. Aarons I, Smith PS, Davies RA, Woodroffe AJ, Clarkson AR. Thin membrane nephropathy: A clinico-pathological study. Clin Nephrol. 1989; 32: 151-158.
26. Cheng IK, Chan KW, Chan MK. Mesangial IgA nephropathy with steroid-responsive nephrotic syndrome: disappearance of mesangial IgA deposits following steroid-induced remission. Am J Kidney Dis. 1989; 14: 361-364.
27. D’Amico G. Natural history of idiopathic IgA nephropathy: role of clinical and histological prognostic factors. Am J Kidney Dis. 2000; 36: 227-237.
28. D’Amico G. Influence of clinical and histological features on actuarial renal survival in adult patients with idiopathic IgA nephropathy, membranous nephropathy, and membranoproliferative glomerulonephritis: Survey of the recent literature. Am J Kidney Dis. 1992; 20: 315-323.
29. Strippoli GF, Manno C, Schena FP. An “evidence-based” survey of therapeutic options for IgA nephropathy: assessment and criticism. Am J Kidney Dis. 2003; 41 (6): 1129-1139.
30. Szeto CC, Lai FM, To KF, Wong TY, Chow KM, Choi PC et al. The natural history of immunoglobulin, a nephropathy among patients with hematuria and minimal proteinuria. Am J Med. 2001; 110 (6): 434-437.
31. Alamartine E, Sabatier JC, Guerin C, Berliet JM, Berthoux F. Prognostic factors in mesangial IgA glomerulonephritis: an extensive study with univariate and multivariate analyses. Am J Kidney Dis. 1991; 18 (1): 12-19.
32. Cameron JS, Turner DR, Heaton J, Williams DG, Ogg CS, Chantler C, Haycock GB, Hicks J. Idiopathic mesangiocapillary glomerulonephritis. Comparison of types I and II in children and adults and long-term prognosis. Am J Med. 1983; 74: 175–192.
33. D’Amico G, Ferrario F. Mesangiocapillary glomerulonephritis. J Am Soc Nephrol. 1992; 2 (10): 159-166.
34. Donadio JV Jr, Offord KP. Reassessment of treatment results in membranoproliferative glomerulonephritis, with emphasis on life-table analysis. Am J Kidney Dis. 1989; 14: 445-451.
UDC 340.6:005.6(470.41)
DOI: 10.20969/VSKM.2016.9(6).138-143
GAZIZYANOVA ROZALIYA M., C. Med. Sci., deputy chief for organizational and methodical work of Republican bureau of forensic medicine of the Ministry of Health of the Republic of Tatarstan, Russia, 420029, Kazan, Sibirsky trakt str., 31a, e-mail: Rozaliya.Gazizyanova@tatar.ru
NIZAMOV ALMAZ KH., Head of quality control office of Republican bureau of forensic medicine of the Ministry of Health of Republic of Tatarstan, Russia, 420029, Kazan, Sibirsky trakt str., 31a
TIMERZYANOV MARAT I., C. Med. Sci., Head of Republican bureau of forensic medicine of the Ministry of Health of the Republic of Tatarstan, Russia, 420029, Kazan, Sibirsky trakt str., 31a
SAFINA JULIYA G., C. Chem. Sci., associate professor of the Department of analytical chemistry, certification and quality management of Kazan National Research Technological University, Russia, 420015, Kazan, K. Marx str., 68
GINYATULLINA LYAISAN R., lieutenant colonel of internal service, deputy chief of the Medical Care unit of the Ministry of Internal Affairs of Russia in Tatarstan Republic, Russia, 420111, Kazan, Lobachevsky str., 13
Abstract. Aim. Assessment of the work activity management of forensic medicine specialists on emergency site from perspective of the quality management system. Normative documents regulating this activity were analyzed; the duties of forensic pathologist were discussed in detail as well as their functional relationships. Material and methods. The study was aiming to investigate the experience of forensic institutions for inspections on the emergency site. The authors have used business process modeling method (Business Process Management) and process approach to the work activity management. Results and discussion. Analysis of the work of forensic pathologist at emergency site from perspective of the process approach has shown that the inspections of the site and of the dead body requires intra- and inter- departmental regulations. The model (algorithm) identifies the most important aspects of the work at the site that does not have a legislative framework. The risks were identified in organization of this activity. Conclusion. The authors propose to implement the algorithm developed from perspective of the process approach for the work activity management at the site in the whole territory of Tatarstan. The model is a good reminder to forensic pathologists, for newly hired employees as well, which allows organizing and providing high quality of work at the site as well as the transparency of proceedings for relatives and friends of the dead person.
Key words: inspection of the emergency site, process approach, forensic expert.
For reference: Gazizyanova RM, Nizamov AKh, Timerzyanov MI, Safina YuG, Ginyatullina LR. Operating procedures of a forensic pathologist on emergency site and their improvement on the basis of quality management approaches in Tatarstan Republic. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 138—143.
References
1. Evgen’ev-Tish EM. Ustanovlenie davnosti smerti v sudebno-medicinskoj praktike (posobie dlja vrachej i studentov) [The establishment of prescription of death in forensic practice: Reference book on forensic medicine]. Kazan’: Kazanskij gosudarstvennyj medicinskij institut [Kazan: Kazan state medical Institute]. 1963; 183 p.
2. Matysheva AA ed. Osmotr trupa na meste ego obnaruzhenija: rukovodstvo [Inspection of corpse in place of its discovery: reference book on forensic medicine]. SPb: Izdatel’stvo «Lan’» [SPb: Publishing House «LAN»]. 1997; 299 p.
3. Prozorovskij VI. Pravila raboty vracha-specialista v oblasti sudebnoj mediciny pri naruzhnom osmotre trupa na meste ego obnaruzhenija (proisshestvija) [Rules of the doctor-expert in forensic medicine at external examination of a corpse to the place of its finding (scene)]. M: Mir. 1978; 55 p.
4. Cipkovskij VP. Osmotr mesta proisshestvija i trupa na meste ego obnaruzhenija. [Examination of the scene and the corpse to the place of its finding]. Kiev: GMI USSR [Kiev: Museum of the USSR]. 1960; 320 p.
5. Sarkisjan BA, Jankovskij VJe. Ustanovlenie davnosti smerti [Establishment of prescription of death]. Barnaul: Altajskij gosudarstvennyj medicinskij universitet [Barnaul: Altai state medical university]. 2008; 39 p.
6. Sadovoj MA, Bedoreva IJu. Sistema menedzhmenta kachestva v uchrezhdenii zdravoohranenija [Quality management System in healthcare institution]. Novosibirsk: ANO «Klinika NIITO» [Novosibirsk: ANO «Clinic of the Institute»]. 2007; 320 p.
7. Rumjanceva ZP. Obshhee upravlenie organizaciej: principy i processy [General management: principles and processes]. M: Infra-M. 2000; 315 p.
UDC 614.21(470.57):351.74
DOI: 10.20969/VSKM.2016.9(6).143-148
NAUSHIRVANOV OLEG R., Head of the Medical Care unit of the Ministry of Internal Affairs in Bashkortostan Republic, Russia, 450015, Ufa, K.Marx str., 59
NIGMATULLIN RUSTEM KH., C. Med. Sci., deputy head of Medical Care unit of the Ministry of Internal Affairs in Bashkortostan Republic, Russia, 450015, Ufa, K.Marx str., 59, e-mail: nigrustem@yandex.ru
FAZLYEV MARAT M., D. Med. Sci., professor, Head of the Hospital of Medical Care unit of the Ministry of Internal Affairs
in Bashkortostan Republic, Russia, 450015, Ufa, K.Marx str., 59
KUTUEV ZEMFIR Z., C. Med. Sci., deputy head of the Hospital of Medical Care unit of the Ministry of Internal Affairs in Bashkortostan Republic, Russia, 450015, Ufa, K.Marx str., 59, e-mail: doczem@mail.ru
Abstract. Aim. Analysis of activity in the system of compulsory health insurance of Medical unit of the Ministry of internal affairs in Bashkortostan Republic in dynamics for the 2012—2016 period. Material and methods. Analysis of work was conducted over a five-year period. It was based on annual reports applying the methods of statistical processing of the material. Patient appealability using compulsory health insurance was studied in detail depending on the type of medical service. The legal base for medical care provision to certain categories of citizens was reflected. Results and discussion. The paper summarizes a five-year experience of interaction of the medical unit of the Ministry of internal Affairs of Russia in Republic of Bashkortostan with the territorial compulsory health insurance Fund and the Ministry of health of the Republic of Bashkortostan, allowing to expand annually allocated planned amount of medical care rendering using compulsory health insurance for the attached contingent. The basic indicators of the hospital in terms of funding for the types of services rendered during the studied period are reflected. The problems encountered during provision of medical care to this category of citizens were considered. Conclusion. Working for 20 years in the system of compulsory health insurance Medical unit of the Ministry of internal affairs of Russia in Republic of Bashkortostan remains effective to fulfill the requirements of Russian legislation and it is able to obtain additional financing for the Unit in providing target social support for this category of citizens.
Key words: compulsory health insurance, territorial fund of compulsory health insurance, organization of medical maintenance, scheduled volume.
For reference: Nauchirvanov OR, Nigmatullin RCh, Fasliev MM, Kutuev ZZ. Organization of work of the medical unit of the Ministry of internal affairs of Russia in the Republic of Bashkortostan in compulsory health insurance system. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 143—148.
References
1. Federal’nyj zakon ot 19/11/2010 №326-FZ «Ob obyazatel’nom medicinskom strahovanii v Rossijskoj Federacii» [On compulsory medical insurance in the Russian Federation]. Sobranie zakonodatel’stva Rossijskoj Federacii [Meeting of the legislation of the Russian Federation]. 2010; 49: 6422.
2. Federal’nyj zakon ot 21/11/2011 №323-FZ «Ob osnovah ohrany zdorov’ya grazhdan Rossijskoj Federacii» [About bases of health protection of citizens of the Russian Federation]. Sobranie zakonodatel’stva Rossijskoj Federacii [Meeting of the legislation of the Russian Federation]. 2011; 48: 6724.
3. Postanovlenie Pravitel’stva Rossijskoj Federacii ot 31 dekabrya 2004 goda № 911 «O poryadke okazaniya medicinskoj pomoshchi, sanatorno-kurortnogo obespecheniya i osushchestvlenie otdel’nyh vyplat nekotorym kategoriyam voennosluzhashchih, sotrudnikov pravoohranitel’nyh organov i chlenam ih semej, a tak zhe otdel’nym kategoriyam grazhdan, uvolennyh s voennoj sluzhby» [About an order of rendering of medical aid, sanatorium and resort support and individual payments to some categories of servicemen, law enforcement officers and their families and separate categories of citizens, dismissed from military service]. Sobranie zakonodatel’stva Rossijskoj Federacii [Meeting of the legislation of the Russian Federation]. 2005; 2: 166.
4. Postanovlenie Pravitel’stva Rossijskoj Federacii ot 30/12/2011 № 1232 «O poryadke okazaniya sotrudnikam organov vnutrennih del Rossijskoj Federacii, otdel’nym kategoriyam grazhdan Rossijskoj Federacii, uvolennyh so sluzhby v organah vnutrennih del, i chlenam ih semej medicinskoj pomoshchi i ih sanatorno-kurortnogo obespecheniya» [On the procedure of providing officers of the internal Affairs of the Russian Federation separate categories of citizens of the Russian Federation dismissed from service in bodies of internal Affairs, and members of their families medical care and sanatorium-resort support]. Sobranie zakonodatel’stva Rossijskoj Federacii [Meeting of the legislation of the Russian Federation]. 2012; 3: 432.
5. Gurov SP, Vasilevskaya SB, Sidorov AG. Opyt vzaimodejstviya FKUZ «MSCH MVD Rossii po Orlovskoj oblasti» s departamentom zdravoohraneniya, territorial’nym fondom obyazatel’nogo medicinskogo strahovaniya i medicinskimi strahovymi kompaniyami v usloviyah «odnokanal’nogo» finansirovaniya [Experience of interaction of Federal state healthcare institution «Medical sanitary unit of Ministry of internal Affairs of Russia across the Oryol region» with the Department of health, territorial Fund of obligatory medical insurance and medical insurance companies in a «single-channel» funding]. Medicinskij vestnik MVD [Medical Bulletin of the Ministry of internal Affairs]. 2016; 2: 14-17.
APPROACHES TO THE METHODOLOGY OF MULTIDISCIPLINARY HOSPITAL PERFORMANCE ASSESSMENT
UDC 614.21:351.74(470.41)
DOI: 10.20969/VSKM.2016.9(6).148-156
SABIROV LENAR F., C. Med. Sci., Head of Clinical hospital of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, associate professor of the Department of public health, economics and health vanagement of Kazan State Medical Academy, Russia, 420059, Kazan, Orenburgsky tract str., 132, tel. 8 (843) 277-88-84, e-mail: hospitalmvdrt1@rambler.ru
SPIRIDONOV ALBERT V., C. Med. Sci., deputy head of Clinical hospital of the Medical Care unit of the Ministry of Internal Affairs of Russia in the Republic of Tatarstan, associate professor of the Department of public health, economics and health management of Kazan State Medical Academy, Russia, 420059, Kazan, Orenburgsky tract str., 132, tel. 8 (843) 291-26-94
Abstract. Aim. Evaluation of effectiveness of activities of the clinical hospital of medical unit of the Ministry of Internal affairs of Russia in the Republic of Tatarstan on the basis of the implemented quality management system. Material and methods. The study was performed on the basis of dynamics of the main indicators of the institution taking into account the data obtained in the course of internal quality management system audits, performance assessment, customer, staff and other interested parties satisfaction monitoring. Results and discussion. There has been a pronounced interest in the development and implementation of adequate health system performance into practice. The impact is assessed according to key indicators taking into account the requirements of international standards and specific field characteristics of the Clinical Hospital. According to the results of the II level internal quality examination the quality factor for the 2011—2015 is steadily high (on the basis of expert maps) (0,89). According to the results of internal expertise quality factor remains stable for 5 years as 1,0. Integrated customer satisfaction (internal and external) tends to increase. It reached 91% in 2015. Conclusion. Assessment of key performance indicators allows timely identification of problematic criteria, correction of which is an effective mechanism for improving quality of care.
Key words: effectiveness, management, quality, auditing, monitoring, process.
For reference: Sabirov LF, Spiridonov AV. Approaches to the methodology of multidisciplinary hospital performance assessment. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 148—156.
References
1. Bedoreva IJu. Nauchnoe obosnovanie sistemy menedzhmenta kachestva medicinskoj organizacii : avtoreferat dissertacii na soiskanie stepeni doktora medicinskih nauk [Scientific substantiation of quality management systems of medical organizations: Abstract Dis for the degree of Dr Med Sciences]. Nauchno–issledovatel’skij institut kompleksnyh problem gigieny i professional’nyh zabolevanij Sibirskogo otdelenija RAMN [Scientific Research Institute of Complex Problems of Hygiene and Occupational Diseases of the Siberian Branch of the Academy of Medical Sciences]. 2009; 32 p.
2. Knjazjuk NF. Nauchno–metodicheskie osnovy povyshenija jeffektivnosti upravlenija medicinskimi organizacijami v sovremennyh uslovijah [Scientific and methodical bases of increase of effective management of the medical organizations in modern conditions]. Avtoreferat dissertacii na soiskanie stepeni doktora medicinskih nauk [The Abstract of the thesis on competition of degree of the doctor of medical sciences]. 2014; 40 p.
3. Lotov ND. Mirovoj opyt vnedrenija sistem kachestva na osnove MS ISO serii 9000 [International experience of implementation of quality systems on the basis of series 9000 ISO MS]. Avtoreferat dissertacii na soiskanie stepeni kandidata jekonomicheskih nauk [The abstract of the thesis on competition of degree of Candidate of Economic Sciences]. 2005; 32 p.
4. Sabirov LF, Spiridonov AV, Frolova JeB, Amirov NB. Organizacija dejatel’nosti mnogoprofil’nogo stacionara vedomstvennoj sistemy zdravoohranenija: uchebnoe posobie [Organization of activities of a multi–profile hospital of a departmental health care system: education guidance]. Kazan’: KGMA [Kazan: KSMA]. 2014; 68 p.
5. Sabirov LF, Spiridonov AV. Ocenka rezul’tativnosti ispol’zovanija metodologii sistemnogo podhoda v upravlenii mnogoprofil’nym stacionarom vedomstvennoj sistemy MVD po Respublike Tatarstan [An assessment of productivity of use of methodology of system approach in management of a multi–profile hospital of the departmental Ministry of Internal Affairs system across the Republic of Tatarstan]. Obshhestvennoe zdorov’e i zdravoohranenie. [Public health and health care]. 2015; 3: 62–65.
6. Sabirov LF, Spiridonov AV. Ocenka rezul’tativnosti sistemy menedzhmenta kachestva klinicheskogo gospitalja FKUZ Mediko–sanitarnoi chasti MVD Rossii po Respublike Tatarstan [An assessment of productivity of quality management system of the Health Service Ministry of Internal Affairs clinical hospital of Russia on Republic of Tatarstan]. Obshhestvennoe zdorov’e i zdravoohranenie [Public health and health care]. 2014; 1: 85–89.
7. Spiridonov AV, Frolova JeB, Amirov NB. Principy organizacii i osnovnye pokazateli dejatel’nosti gastrojenterologicheskoj sluzhby mnogoprofil’nogo stacionara [Principles of the organization and main indicators of activities of gastroenterologichesky service of a multi–profile hospital]. Kazan’: KGMA [Kazan: KSMA]. 2014; 38 p.
8. Tajc BM. Sistema upravlenija kachestvom krupnogo stacionara jekstrennoj pomoshhi kak podsistema obshhegorodskoj sistemy upravlenija kachestvom [Quality management system of a large hospital of the emergency help as subsystem of a city quality management system]. Menedzher zdravoohranenija [Manager of health care]. 2008; 2: 21–31.
9. Jemanujel’ AV. Vnedrenie mezhdunarodnyh standartov sistemy ISO v Rossii — problemy i perspektivy [Implementation of international standards of the ISO system in Russia — problems and prospects]. Menedzhment kachestva v sfere zdravoohranenija i social’nogo razvitija [Quality management in health sector and social development].
2008; 3: 55–58.
UDC 614.29:351.74:004
DOI: 10.20969/VSKM.2016.9(6).156-162
SIDORENKO VITALY A., C. Med. Sci., Honored doctor of the Russian Federation, deputy head of the Department of material and technical logistic of the Ministry of Internal Affairs of the Russian Federation, Chief of Administration of civilian health and medical program, major general of internal service, Russia, 123060, Moscow, Raspletin str., 26, tel. 8-495-214-03-01, e-mail: sidorenko@mail.ru
Abstract. Aim. The mail goal was to evaluate implementation of automated work stations aiming for medical specialists at military physician boards of the Ministry of Internal Affairs of Russia as a part of unified information service that provides conduction of military medical expertise via department’s unified information space. Material and methods. «Medicine» is the original software — the information service that provides operation of government military physician boards. «Medicine» was being implemented stepwise all across 80 Russian regions at the medical facilities during 2015—2016. The system was introduced through remote connection of the facilities via secure channels to the main center that was processing data needed to interact with the service. Results and discussion. Introduction of the «Medicine» has made it possible to create digital entries to form medical database, to automate compilation of all outgoing expert documents, to store information on every patient visit to military physicians all across Russian Federation, to exchange information between the boards regarding the state of health of examined contingent, to exclude the possibility of presenting inaccurate or false information to the examinees and to keep track of non-effective individuals, to enable responsible officials to control all stages of medical examination, to automate the creation of statistical reports, to provide a complete data protection and to exclude unauthorized access to personal and medical data or expert reports. Conclusion. The «Medicine» information service is a qualitatively new stage of automation of military physician boards of the Ministry of internal affairs of Russia. The opportunities offered with the introduction of the service are not limited only by saving time spent on a purely mechanical document issue, but also allow to design and develop the algorithms and mechanisms aiming to create a unified architecture to process expert solutions and avoid errors on adjudication procedure.
Key words: military medical expertise, military physician board, medical examination, automated management systems, information technologies.
For reference: Sidorenko VA. Trial implementation of automated management systems supporting military physician boards of the Ministry of internal affairs of Russia. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 156—162.
References
1. Ganishev AV. Obuchenie noveishcim informacionno-kommunikacionnym technologijam dlia organizacii medicinskogo osvidetel’stvovania v organah vnutrennich del [Learn the latest information and communication technologies for the organization of the medical examination in the internal affairs bo]. Medicinskiy Vestnik MVD [Medical Bulletin MIA]. 2015; 3: 9.
2. Proekt: Edinaja Sistema informacionno-analiticheskogo obespechenija dejatel’nosti MVD RF. [Project: A unified system of information and analytical support for the activities of the Ministry Internal Affairs of Russian Federation]. Elektronnyi resurs www.tadviser.ru [Electronic resource www.tadviser.ru].
3. Ganishev AV, Shutko GV. Organiza dejatel’nosti voenno-vrachebnych kovissiy organov vnurennich del I chastnye voprosy voenno-vrachebnoy ekspertizy [Organization of activity of military medical commissions of internal affairs and private issues of military-medical examination]. Domodedovo: VIPK MVD Rossii [MIA of Russian Federation]. 2015; 23 p.
4. Sidorenko VA. Voenno-vrachebnaja ekspertiza v organach vnutrennich del Rossiyskoy Federacii [Military-medical examination in the Internal Affairs of Russian Federation]. Medicinskiy Vestnik MVD [Medical Bulletin MIA]. 2016; 4: 3.
5. Mejzdunarodnyi standart «Informacyonnye technologii v medicine — elektronnaja medicinskaja zapis’» ISO/TR20514:2005 [International Standard «Information Technologies in Medicine — electronic medical record» ISO / TR20514: 2005].
6. Nacional’nyi standart Rossiyskoy Federacii «Elektronnaya istorija bolezni» GOST R 52636-2006 [Russian Federation National Standard «Electronic Case History» GOST R 52636-2006].
HYPERPARATHYROIDISM AND UROLITHIASIS: DIAGNOSTICS ERRORS (clinical case)
UDC 616.447-008.6:616.62-003.7-035.7
DOI: 10.20969/VSKM.2016.9(6).163-168
NADEEVA ROZALIYA A., C. Med. Sci., associate professor of the Department of general medical practice of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, e-mail: rosa.nadeeva@gmail.com
KAMASHEVA GULNARA R., C. Med. Sci., associate professor of the Department of general medical practice of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, e-mail: kamasheva73@rambler.ru
AMIROV NAIL B., D. Med. Sci., professor of the Department of general medical practice of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, e-mail: namirov@mail.ru
Abstract. Aim. To invite attention of professionals to hyperparathyroidism in order to assure its early diagnostics in patients with bone and nephrological masks of the disease. Material and methods. The incidence of primary hyperparathyroidism among patients with urolithiasis is 8%. Visceral form with predominant renal damage occurs in over 60% of cases of primary hyperparathyroidism manifest. Kidney damage may be the only manifestation of primary hyperparathyroidism. Often it occurs in the form of urolithiasis. The surgical intervention in primary hyperparathyroidism is not a method of urolithiasis treatment, but just a way to get rid of the patient concretions. Results and discussion. The case is a patient with recurrent kidney stones, over which the surgery was performed twice. Unfortunately, the removal of calculus does not cure the patient if the cause of the changes that led to the development of urolithiasis is not known. Besides complaints of the patient and the clinical manifestations of hyperparathyroidism screening test for blood calcium level was not carried out on time, which has led to the renal damage with the development of urolithiasis and osteoporosis with pathologic fractures. Adenoma of the parathyroid gland and primary hyperparathyroidism were detected during occasional visit to endocrinologist followed by successful parathyroidectomy. Conclusion. The clinical case demonstrates errors and late diagnostics of primary hyperparathyroidism, which is related to poor knowledge of the manifestations of hyperparathyroidism, its bone and nephrology masks as well as the necessity to introduce the serum calcium level measurement in routine biochemical practice.
Key words: primary hyperparathyroidism, urolithiasis disease, hypercalcemia, osteoporosis.
For reference: Nadeeva RA, Kamasheva GR, Amirov NB. Hyperparathyroidism and urolithiasis: diagnostics errors (clinical case). The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 163—168.
References
1. Dedova II, Mel’nichenko GA ed. Racional’naja farmakoterapija zabolevanij jendokrinnoj sistemy i narushenij obmena veshhestv, 2—e izdanie [Rational pharmacotherapy of diseases of the endocrine system and metabolic disorders]. Moskva [Moscow]: Litterra. 2013; 1080 p.
2. Dedova II, Mel’nichenko GA ed. Nacional’noe rukovodstvo po jendokrinologii. [National leadership on endocrinology]. Moskva [Moscow]: GJeOTAR—Media. 2013; 1072 p.
3. Smirnova NA ed. Patofiziologija jendokrinnoj sistemy [Pathophysiology of the endocrine system]. Moskva [Moscow]: Binom. 2009; 336 p.
4. Kushner D. Calcium and the Kidney. The American Journal of Clinical Nutrition. 2006; 4 (5): 561—579.
5. Parks J, Coe F, Favus M. Hyperparathyroidism in nephrolithiasis. Arch Intern Med. 1980; 140: 1479.
6. Pigarova EA. Fiziologija obmena kal’cija v pochkah [Physiology of calcium metabolism in kidneys]. Ozhirenie i metabolizm [Obesity and metabolism]. 2011; 4: 3—8.
7. Beljaeva AV, Mokrysheva NG, Rozhinskaja LJa. Koncentracionnaja funkcija pochek pri pervichnom giperparatireoze [Concentration renal function in primary hyperparathyroidism]. Ozhirenie i metabolism [Obesity and metabolism]. 2009; 1: 8—12.
8. Rejnmark L, Vestergaard P, Mosekilde L. Nephrolithiasis and renal calcifications in primary hyperparathyroidism. J Clin Endocrinol Metab. 2011; 96 (8): 2377—2385.
9. Mollerup CL, Vestergaard P, Frоkjær VG, Mosekilde L, Christiansen P, Blichert—Toft M. The risk of renal stone events in primary hyperparathyroidism before and after parathyroid surgery: a controlled historical follow up study. BMJ. 2002; 325: 807—810.
10. Mollerup CL, Lindewald H. Renal stones and primary hyperparathyroidism: natural history of renal stone disease after successful parathyroidectomy. World J Surg. 1999; 23 (2): 173—175.
11. Mollerup CL. Risk of renal stone events in primary hyperparathyroidism before and after parathyroid surgery: controlled retrospective follow up study. BMJ. 2002; 325 (7368): 807.
12. Söreide JA, van Heerden JA, Grant CS, Lo CY, Ilstrup DM. Characteristics of patients surgically treated for primary hyperparathyroidism with and without renal stones. Surgery. 1996; 120 (6): 1033—1038.
13. Iglesias P, Dıez J. Сurrent treatments in the management of patients with primary hyperparathyroidism. Postgrad Med J. 2009; 85: 15—23.
14. Kalinchenko SA, Pigarova EA, Gusakova DA, Pleshcheeva AV. Vitamin D i mochekamennaya bolezn’ [Vitamin D and urolithiasis]. Consilium Medicum. 2012; 12 (14): 97—103.
15. Alaev DS, Kotova IV. Nefrolitiaz pri pervichnom giperparatireoze [Nephrolitiasis in primary hyperparathyroidism]. Al’manah klinicheskoj mediciny [Almanac of clinical medicine]. 2013; 28: 58—60.
16. Dedov II, Rozhinskaja LJa, Mokrysheva NG, Vasil’eva TO. Jetiologija, patogenez, klinicheskaja kartina, diagnostika i lechenie pervichnogo giperparatireoza [Etiology, pathogenesis, clinical picture, diagnosis and treatment of primary hyperparathyroidism]. Osteoporoz i osteopatii [Osteoporosis and osteopathy]. 2010; 1: 13—18.
17. Carling I, Rastad J, Szabo E et al. Reduced parathyroid vitamin D receptor messenger ribonucleic acid levels in primary and secondary hyperparathyroidism. J Clin Endocrinol Metab. 2000; 85: 2000—2003.
18. Carling I, Szabo E, Bai M et al. Familial hypercalcemia and hypercalciuria caused by a novel muta tion in the cytoplasmic tail of the calcium receptor. J Clin Endocrinol Metab. 2000; 85: 2042—2047.
19. Guidelines for the Management of Asymptomatic Primary Hyperparathyroidism: Summary Statement from the Fourth International Workshop. J Clin Endocrinol Metab. 2014; 99 (10): 3561–3569.
20. Shah VN, Shah CS, Bhadada SK, Rao D. Effect of 25 (OH) D Replacements in Patients With Primary Hyperparathyroidism (PHPT) and Coexistent Vitamin D Deficiency on Serum 25(OH) D, Calcium and PTH Levels: A Meta—analysis and Review of Literature. Clin Endocrinol. 2014; 80 (6): 797–803.
SELECTED ASPECTS OF THE NEED IN INCREASED GLUTAMIC ACID CORRECTION IN SEPTIC PATIENTS
UDC 616.94-07:616.153.466.64-074
DOI: 10.20969/VSKM.2016.9(6).169-178
ALEKSEEVA ELENA V., С. Мed. Sci., anesthesiologist of the Department of intensive care of Central Clinical Hospital and Clinic of the outpatient, Russia, 121359, Moscow, Marshal Timoshenko str., 15, tel. 8-910-442-11-37, e-mail: aev_69@mail.ru
Abstract. Aim. Sepsis is associated with an increased level of kynurenic acid, which contributes to hypofunction of 3 neurotransmitter systems and to the decrease of survival function. A number of amino acids inhibit the formation of kynurenic acid. The trial was performed on septic patients with deterioration of their condition. Plasma levels of amino acids that reduce the formation of kynurenic acids were identified in order to determine an optimal way of correction. Material and methods. We analyzed data from 2 groups of resuscitated patients. Group I (n=43) — septic patients, group II (n=19) — patients without sepsis. Group 1 consisted of subgroup 1 (n=24) — «severe sepsis», subgroup 2 (n=19) — «septic shock». Groups and subgroups were compatible by the content of phenylalanine, leucine, isoleucine, glutamic acid, alanine, methionine, aspartic acid, glutamine, tyrosine. Amino acid concentrations in plasma were determined by high performance liquid chromatography — mass spectrometry. Statistical data processing was carried out by using Statistica 12 software. Results and discussion. There were significant differences between groups and sub-groups only in decreased content of glutamic acid rates. In group I it was higher (9,8-fold), p=0,00028; more in subgroup 1 (2-fold) p=0,0208. 28-day survival rate was higher in patients without reduced level of glutamic acid, relative to the reference parameters, p=0,00074. Conclusion. Administration of amino acids inhibits production of kynurenic acid that significantly changes glutamic acid level in septic patients with deterioration of their condition. Reduced level of glutamic acid in the blood plasma is an unfavorable factor for the course of pathological process in critical patients.
Key words: glutamic acid, kynurenic acid, sepsis, critical patients.
For reference: Alekseeva EV. Selected aspects of the need in increased glutamic acid correction in septic patients. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (6): 169—178.
References
1. Changes in plasma kynurenic acid concentration in septic shock patients undergoing continuous veno-venous haemofiltration / W. Dabrowski, T. Kocki, J. Pilat [et al.] // Inflammation. — 2014. — Vol. 37, № 1. — P.223—234.
2. Plasma kynurenic acid concentration in patients undergoing cardiac surgery: effect of anaesthesia / E. Kotlinska-Hasiec, P. Nowicka-Stazka, J. Parada-Turska [et al.] // Arch. Immunol. Ther. Exp. (Warsz). — 2015. — Vol. 63, № 2. — Р.129—137.
3. An observational cohort study of the kynurenine to tryptophan ratio in sepsis: association with impaired immune and microvascular function / C.J. Darcy, J.S. Davis, T. Woodberry [et al.] // PLoS One. — 2011. — Vol. 6, № 6. — е 21185.
4. Enhanced indoleamine 2,3-dioxygenase activity in patients with severe sepsis and septic shock / P. Tattevin, D. Monnier, O. Tribut [et al.] // J. Infect. Dis. — 2010. — Vol. 201, № 6. — Р.956—966.
5. Schmidt, S.V. New Insights into IDO Biology in Bacterial and Viral Infections/ S.V. Schmidt, J.L. Schultze // Front Immunol. — 2014. — Vol. 5. — P.384.
6. Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders / K. Sas, H. Robotka, J. Toldi [et al.] // J. Neurol. Sci. — 2007. — Vol. 257, № 1/2. — P.221—239.
7. Albuquerque, E.X. Kynurenic acid as an antagonist of α7 nicotinic acetylcholine receptors in the brain: facts and challenges / E.X. Albuquerque, R. Schwarcz // Biochem Pharmacol. — 2013. — Vol. 85, № 8. — P.1027—1032, 1029—1032.
8. New prospects for antipsychotic treatment — the role of the kynurenine pathway / H. Karakuła-Juchnowicz, M. Flis, K. Szymona [et al.] // Psychiatr. Pol. — 2014. — Vol. 48, № 6. — P.1167—1177.
9. Early activation of the kynurenine pathway predicts early death and long-term outcome in patients resuscitated from out-of-hospital cardiac arrest / G. Ristagno, R. Latini, J. Vaahersalo [et al.] //J. Am. Heart Assoc. — 2014. — Vol. 3, № 4. — e. 001094.
10. Tryptophan degradation and serum neopterin concentrations
in intensive care unit patients / G. Girgin, T.T. Sahin, D. Fuchs [et al.] // Toxicol. Mech. Methods. — 2011. — Vol. 21, № 3. — P.231—235.
11. Stone, T.W. Kynurenine pathway inhibition as a therapeutic strategy for neuroprotection / T.W. Stone, C.M. Forrest, L.G. Darlington // FEBS J. — 2012. — Vol. 279, № 8. — P.1386 —1397.
12. Amino acids inhibit kynurenic acid formation via suppression of kynurenine uptake or kynurenic acid synthesis in rat brain in vitro / A. Sekine, M. Okamoto, Y. Kanatani [et al.] // Springerplus. — 2015. — Vol. 4. — P.48.
13. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012 / R. Dellinger, M. Levy, A. Rhodes [et al.] // Crit Care Med. — 2013. — Vol. 41, № 2. — P.580—637.
14. Assessing Glutamatergic Function and Dysfunction in Peripheral Tissues / L. Tremolizzo, G. Sala, C.P. Zoia [et al.] // Current Medicinal Chemistry. — 2012. — Vol. 19. — P.1310—1315.
15. Поздеев, В.К. Методы нейрохимических исследований в клинике / В.К. Поздеев, Н.В. Поздеев. — СПб.: Реноме,
2013. — 312 c. [Reference: Pozdeev VK, Pozdeev NV. Metody neyrokhimicheskikh issledovaniy v klinike [Methods of neurochemical studies in the clinic]. SPb: Renome [SPb: Renome]. 2013; 312 p.]
16. Özdemir, V. Innovation Management? Orienting Sepsis R&D and Technology Transfer Towards Stratified Medicine / V. Özdemir, N. Hekim // EBioMedicine. — 2016. — Vol. 6. — P.8—9.
17. Transcriptomic Biomarker to Quantify Systemic Inflammation in Sepsis — A Prospective Multicenter Phase II Diagnostic Study / M. Bauer, E.J. Giamarellos-Bourboulis, A. Kortgen [et al.] // E. Bio. Medicine. — 2016. — Vol. 6. — P.114—125.
18. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) / M. Singer, C.S. Deutschman, C.W. Seymour [et al.] // JAMA. — 2016. — Vol. 315, № 8.
19. Metabolomics in pneumonia and sepsis: an analysis of the GenIMS cohort study / C.W. Seymour, S. Yende, M.J. Scott [et al.] // Intensive Care Med. — 2013. — Vol. 39, № 8. — P.1423—1434.
20. Metabolomics as a novel approach for early diagnosis of pediatric septic shock and its mortality/ B. Mickiewicz, H.J. Vogel, H.R. Wong [et al.] // Am. J. Respir. Crit. Care Med. — 2013. — Vol. 187, № 9. — Р.967—976.
21. An integrated clinico-metabolomic model improves prediction of death in sepsis / R.J. Langley, E.L. Tsalik, J.C. van Velkinburgh [et al.] // Sci. Transl. Med. — 2013. — Vol. 5, № 195. — P.195.
22. Integration of metabolic and inflammatory mediator profiles as a potential prognostic approach for septic shock in the intensive care unit / B. Mickiewicz, P. Tam, C.N. Jenne [et al.] // Crit Care. — 2015. — Vol. 19. — P.11.
23. Decreased glutamate, glutamine and citrulline concentrations in plasma and muscle in endotoxemia cannot be reversed by glutamate or glutamine supplementation: a primary intestinal defect ? / C. Boutry, H. Matsumoto, C. Bos [et al.] // Amino Acids. — 2012. — Vol. 43, № 4. — P.1485—1498.
24. Noworyta-Sokołowska, K. LPS-induced oxidative stress and inflammatory reaction in the rat striatum / K. Noworyta-Sokołowska, A. Górska, K. Gołembiowska //Pharmacol. Rep. — 2013. — Vol. 65, № 4. — Р.863—869.
25. Amino acid metabolism in leg muscle after an endotoxin injection in healthy volunteers / R.F. Vesali, M. Klaude, O. Rooyackers [et al.] // Am. J. Physiol. Endocrinol. Metab. — 2005. — Vol. 288, № 2. — P.360—364.
26. Freund, H.R. Amino acid derangements in patients with sepsis: treatment with branched chain amino acid rich infusions / H.R. Freund, J.A. Ryan Jr., J.E. Fischer // Ann. Surg. — 1978. — Vol. 188, № 3. — P.423—430.
27. Alterations in glutamine metabolism and its conversion to citrulline in sepsis / C. Kao, J. Hsu, V. Bandi, [et al.] // Am. J. Physio.l Endocrinol. Metab. — 2013. — Vol. 304, № 12. — P.1359—1364.
28. Decreased plasma glutamate in early phases of septic shock with acute liver dysfunction is an independent predictor of survival / M. Poeze, Y.C. Luiking, P. Breedveld [et al.] // Clin. Nutr. — 2008. — Vol. 27, № 4. — P.523—530.
29. Altered balance of the aminogram in patients with sepsis — The relation to mortality / T. Hirose, K. Shimizu, H. Ogura [et al.] // Clin. Nutr. — 2014. — Vol. 33, № 1. — P.179—182.
30. Mortality prediction in patients with severe septic shock: a pilot study using a target metabolomics approach / M. Ferrario, A. Cambiaghi, L. Brunelli [et al.] // Sci. Rep. — 2016. — Vol. 6. — P. 20391.