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ORIGINAL ARTICLES

Growth and development of very-low-birth-weight infants in first year of life. G.A. Alyamovskaya, E.S. Keshishian, E.S. Sakharova P.6

The characteristic of genes of the main histological compatibility complex and perinatal anamnesis at premature infants with bronchopulmonary dysplasia. E.N. Akhmadeeva, P.V. Panov, L.D. Panova, S.N. Kulikova P.14

The expert analysis of perinatal mortality in N-sky region by the year 2012. V.V. Vetrov, D.O. Ivanov P.20

Syndrome of the increased intracranial pressure at children who had cerebral ischemia at neonatal period. D.D. Gaynetdinovа, D.F. Musinа P.25

Analysis of case histories of children receiving treatment at the department of pathology of the newborn. D.O. Ivanov, Yu.V. Petrenko, T.A. Fedoseeva P.30

Role of insulin-like growth factor-1 in fetal and early postnatal growth in children born small for gestational age. K.F. Islamova, Yu.V. Petrenko, D.O. Ivanov, S.N. Filippova P.36

Model of urologic treatment in newborns and infants. M.V. Levitskaya, L.B. Menovshchikova, O.G. Mokrushina, E.V. Yudina, A.I. Gurevich, V.S. Shumikhin, A.S. Gurskaya P.40

The possibility of microchimerism identifying by HLA-A, B, C, DRB1, DQB1 typing by PCR-SSP in the mothers and neonates. N.A. Treskina, O.Ya. Volkova, Yu.V. Petrenko, V.I. Smirnova, D.O. Ivanov P.45

Peculiarity of methods’ application of imaging modalities used in pediatric practice. G.E. Trufanov, V.A. Fokin, D.O. Ivanov, V.V. Riazanov, V.V. Ipatov, M.Yu. Skvortsova, D.V. Nesterov, G.K. Sadykova, E.M. Mikhaylovskaya.48

REVIEW

Postnatal adaptation respiratory system in premature infants and correction (literature review). I.V. Vinogradova P.55

Integrated rehabilitation premature infants in the first year of life. E.V. Volyanyuk, A.I. Safina P.59

New in the classification and diagnosis of acute kidney injury (AKI) newborn. M.A. Daminova, A.I. Safina, G.A. Khamzina P.63

Ongenital nephrotic syndrome: etiology, diagnosis, treatment (review). E.K. Petrosyan P.70

Problems of breastfeeding of the premature infants. N.L. Rybkina, A.I. Safina P.78

Neurodevelopmental outcomes in very-low-birth-weight infants. E.S. Sakharova, E.S. Keshishian, G.A. Alyamovskaya P.84

Malnutrition in low birth weight infants (review). V.A. Skvortsova, T.E. Borovik, O.K. Netrebenko P.91

Modern treatment of neonatal sepsis. Kh.S. Khaertynov, M.A. Satrutdinov, E.A. Agafonova P.96

CLINICAL LECTURE

Neonatal thrombocytopenia. I.I. Zakirov, A.I. Safina P.102

The interpretation of ecg in the practice of neonatology. I.Ya. Lutfullin, A.I. Safina, Z.R. Dolgova P.108

Osteopenia of prematurity. А.I. Safina P.114

Pattern of pathogenesis, diagnostics and treatment of urinary tract infections in newborn and infancy, feasibility of therapeutics. O.L. Chugunova, M.V. Shumikhina, S.V. Dumova, A.S. Foktova P.119

Perinatal comprehensive strategy for management of neonatal respiratory distress syndrome in preterm infants: basic points of the European consensus. 2013 update. O.A. Stepanova, A.I. Safina P.129

WHEN THE ISSUE WAS IN PRINT

Рarameteres of quasi-attractors of women with endometriosis at hirudoreflexotherapy. R.N. Zhivoglyad, A.G. Danilov, O.A. Bondarenko, N.V. Zhivaeva P.135

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ORIGINAL ARTICLES

Growth and development of very-low-birth-weight infants in first year of life

Galina A. Alyamovskaya, Elena S. Keshishian, Elena S. Sakharova

Abstract. This article evaluates the influence of feeding and intensive care approach in very-low-birth-weight (VLBW) infants on the growth and development to 12 months of corrected age. Ninety three infants were studied; in hospitals 33 were breastfed (14 — with fortified breast milk), 47 were fed with preterm formula, 13 — with standard term formula. Twenty five were treated with new practice of intensive care, others were in standard. Infants, who were treated with new standards of intensive care and fed with fortified breast milk, had the best growth rates to 40 weeks of postmenstrual age and then — to 12 months of corrected age. Most of infants with low weight gain to 40 weeks of postmenstrual age have the weight less than 10-percentile to 12 months of corrected age and psychomotor development delay.

Key words: premature infants, growth, development.

 

References

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2. Sovremennye zadachi vskarmlivaniya nedonoshennyh detei / A.B. Dulenkov, O.V. Potapova, O.I. Mileva, V.P. Geras’kina // Praktika pediatra. — 2008. — № 1. — S.38—40.
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5. Infant growth before and after term: effects on neurodevelopment in preterm infants / M.B. Belfort, S.L. Rifas Shiman, T. Sullivan [et al.] // Pediatrics. — 2011. — Vol. 128. — P.899—906.
6. Improving growth of very low birth weight infants in the first 28 days / B.T. Bloom, J. Mulligan, C. Arnold [et al.] // Pediatrics. — 2003. — Vol. 112. — P.8—14.
7. Cooke, R.J. Postnatal growth and development in the preterm and small for gestational age infants. Importance of growth for health and development / R.J. Cooke, A. Lucas, M. Makrides, E.E. Ziegler eds. // Nestle Nutr. Inst. Workshop Ser Pediatr Program. — 2010. — Vol. 65. — P.85—98.
8. Growth failure in the preterm infant: can we catch up? / A.M. Dusick, B.B. Poindexter, R.A. Echrecranz [et al.] // Semin perinatol. — 2003. — Vol. 27. — P.302—310.
9. Growth in the neonatal intensive care unit influences neurodevelopmental and growth outcomes of extremely low birth weight infants / R.A. Ehrenkranz, A.M. Dusick, B.R. Vohr [et al.] // Pediatrics. — 2006. — Vol. 117. — P.1253— 1261.
10. Embleton, N.E. Postnatal malnutrition and growth retardation: an inevitable consequence of current recommendations in preterm infants? / N.E. Embleton, N. Pang, R.J. Cooke // Pediatrics. — 2001. — Vol. 107. — P.270—273.
11. Franz, A.R. Intrauterine, early neonatal, and postdischarge growth and neurodevelopmental outcome at 5,4 years in extremely preterm infants after intensive neonatal nutrition support / A.R. Franz, F. Pohlandt, H. Bode // Pediatrics. — 2009. — Vol. 123. — P.101—109.
12. Improved Growth and Decreased Morbidities in < 1000 g Neonates After Early Management Changes / C.A. Geary, R.A. Fonseca, M.A. Cascev, M.H. Malloy // J. Perinatol. — 2008. — Vol. 28, № 5. — P.347—353.
13. Nutritional practices in the neonatal intensive care unit: analysis of a 2006 neonatal nutritional survey / D.M. Hans, M. Pylipow, J.D. Long [et al.] // Pediatrics. — 2009. — Vol. 123 (1). — P.51—57.
14. Hintz, S.R. Neurodevelopmental and growth outcomes of extremely low birth weight infants after necrotizing enterocolitis / S.R. Hintz, D.E. Kendrick, B.J. Stoll // Pediatrics. — 2005. — Vol. 115. — P.696—703.
15. Postdischarge growth and development in a predominantly Hispanic, very low birth weight population / G.C. Powers, R. Ramamurthy [et al.] // Pediatrics. — 2008. — Vol. 122. —P.1258—1265.
16. Human milk consumption and full enteral feeding among infants who weigh ≤ 1250 grams / P.M. Sisk, C.A. Lovelady [et al.] // Pediatrics. — 2008. — Vol. 121. — P.1528—1533.
17. First-week protein and energy intakes are associated with 18-month developmental outcomes in extremely low birth weight infants / B.E. Stephens, R.V. Walden, R.A. Gargus [et al.] // Pediatrics. — 2009. — Vol. 123. — P.1337— 1343.

 

The characteristic of genes of the main histological compatibility complex and perinatal anamnesis at premature infants with bronchopulmonary dysplasia

Elza N. Akhmadeeva, Pavel V. Panov, Ludmila D. Panova, Svetlana N. Kulikova

Abstract. The present article is devoted to the analysis of perinatal anamnesis and genes of the main histological compatibility complex in bronchopulmonary dysplasia (BPD) development in premature infants with very low body weight at birth (n=108) in comparison with premature infants of like gestational age, but without BPD development (n=367). The most significant maternal (вronchial asthma, alcoholism, tobacco smoking, horioamnionitis) and neonatal (APV more than 6 days, therapy with high concentration of oxygen, extensive hemorrhages in a brain, an open arterial channel, a male of the baby) risk factors for BPD development as well as positive association with certain groups of A, B, DRB1 alleles of HLA-region loci have been determined in infants with gestational age less than 32 weeks. This confirms the possibility of the main histological compatibility complex genes impact on BPD development.

Key words: bronchopulmonary dysplasia, genes of the main histological compatibility complex.

 

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The expert analysis of perinatal mortality in N-sky region by the year 2012

Vladimir V. Vetrov, Dmitriy O. Ivanov

Abstract. In article the analysis of first documentation 53 cases perinatal mortality in N-sky region are proved. The mistakes in leading of pregnants women by ambulation and hospitalization of stages are revealed, especially in establishments of the first level. The insuperable, conditional insuperable and certaintly insuperable of fetus the death were accordingly in 18,1, 49,1 and 32,7% of cases. The clinical examples are implemented.

Key words: perinatal mortality, pregnancy.

 

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Syndrome of the increased intracranial pressure at children who had cerebral ischemia at neonatal period

Dina D. Gaynetdinovа, Dina F. Musinа

Abstract. A total of 58 children with a diagnosis of «perinatal hypoxic-ischemic brain damage in the form of hypertensive syndrome» at the age of 1 year. We used clinical, neurological, neuroimaging, laboratory and statistical methods. It was found that the majority of children who have suffered by hypoxia during labor and with clinical signs and symptoms of neurosonographycal intracranial pressure there is a decrease in hemoglobin of varying degrees. When comparing data of neurosonography with hemoglobin found that among children with primary accumulation of cerebrospinal fluid in the interhemispheric fissure numerically dominated children with anemia. Extended the ventricular system in the majority of cases corresponds to hemoglobin age appropriate. Тhe reduced hemoglobin aggravate symptoms of intracranial hypertension and the continued existence of anemia leads to tissue edema, which leads to a rapid increase in degenerative changes in the brain, causing mental retardation, mental and physical development of children.

Key words: increased intracranial pressure, hypertension syndrome, hypoxia, anemia, neurosonography.

 

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Analysis of case histories of children receiving treatment at the department of pathology of the newborn

Dmitry O. Ivanov, Yury V. Petrenko, Tatiana A. Fedoseeva

Abstract. Case histories of 32 children who had suffered severe perinatal diseases were analyzed. Over-diagnosis of perinatal lesions of the nervous system, including those of infectious origin, resulted in increase of hospital stay duration, excess amount of diagnostic procedures, medicines prescription (some of which had not passed all necessary control procedures to be recommended for use in infants), nosocomial infection, polypharmacy. A step by step diagnostic scheme for perinatal lesions of the nervous system evaluation in newborns is given.

Key words: newborn, perinatal pathology.

 

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4. Yacyk, G.V. Diagnostika i kompleksnaya reabilitaciya perinatal’noi patologii novorozhdennyh detei / G.V. YAcyk. — M.: Pediatr’, 2012. — 155 s.
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6. Kapustina, O.G. Gipoksicheski-ishemicheskaya ence- falopatiya u novorozhdennyh: sovremennoe sostoyanie problemy / O.G. Kapustina, D.N. Surkov, D.O. Ivanov // Byulleten’ Federal’nogo centra serdca, krovi i endokrinologii im. V.A. Almazova. — 2013. — № 2. — S.84—105.
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10. Petrenko, Yu.V. Ocenka organnoi nedostatochnosti u novorozhdennyh / Yu.V. Petrenko, D.O. Ivanov, E.A. Kurzina // Byulleten’ Federal’nogo centra serdca, krovi i endokrinologii im. V.A. Almazova. — 2011. — № 2. — S.43—50.
11. Prognozirovanie sostoyaniya zdorov’ya v katamneze u detei, perenesshih tyazheluyu perinatal’nuyu patologiyu / E.A. Kurzina, O.B. Zhidkova, Yu.V. Petrenko [i dr.] // Detskaya medicina Severo-Zapada. — 2010. — T. 1, № 1. — S.22—27.
12. Vozmozhnosti prognozirovaniya razvitiya kriticheskih sostoyanii u novorozhdennyh v zavisimosti ot sostoyaniya zdorov’ya materi / O.B. Zhidkova, E.A. Kurzina, D.O. Ivanov, Yu.V. Petrenko // Vestnik Rossiiskoi voenno-medicinskoi akademii. — 2012. — T. 4. — S.213—216.
13. Zdorov’e detei v vozraste 8—11 let, perenesshih tyazheluyu patologiyu perinatal’nogo perioda / D.O. Ivanov, Yu.V. Petrenko, E.A. Kurzina [i dr.] // Byulleten’ Federal’nogo centra serdca, krovi i endokrinologii im. V.A. Almazova. — 2013. — № 2. — S.5—11.
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16. Pal’chik, A.B. Gipoksicheski-ishemicheskaya encefalopatiya / A.B. Pal’chik, N.P. Shabalov. — M.: MEDpress-inform, 2011. — 243 s.
17. Shabalov, N.P. Gemostaz v dinamike pervoi nedeli zhizni kak otrazhenie mehanizmov adaptacii k vneutrobnoi zhizni novorozhdennogo / N.P. Shabalov, D.O. Ivanov, N.N. Shabalova // Pediatriya. — 2000. — № 3. — S.22—27.
18. Shabalov, N.P. Sepsis novorozhdennogo / N.P. Shabalov, D.O. Ivanov // Pediatriya. Zhurnal im. G.N. Speranskogo. — 2003. — № 5. — S.46—56.
19. Ivanov, D.O. Narusheniya obmena glyukozy u novorozhdennyh / D.O. Ivanov // Detskaya medicina Severo-Zapada. — 2011. — T. 2, № 1. — S.68—91.
20. Ivanov, D.O. Persistiruyuschaya legochnaya gipertenziya u novorozhdennyh/ D.O. Ivanov, D.N. Surkov, M.A. Ceitlin // Byulleten’ Federal’nogo centra serdca, krovi i endokrinologii im. V.A. Almazova. — 2011. — № 5. — S.94—112.

 

Role of insulin-like growth factor-1 in fetal and early postnatal growth in children born small for gestational age

Kristina F. Islamova, Yury V. Petrenko, Dmitry O. Ivanov, Sofia N. Filippova

Abstract.This article is devoted to the investigation of changes in levels of insulin-like growth factor (IGF-1) and growth hormone (GH) in cord blood and at 3 month of life in association with birth weight and tempo of postnatal growth. The prospective study includes 48 small for gestational age (SGA) and 31 appropriate for gestational age (AGA)infants. The IGF-1 levels in cord blood in SGA were lower than AGA infants. There is no different between levels of GH in cord blood in SGA and AGA newborns. In age of 3 month of life the IGF-1 and GH levels were similar in two groups.Most SGA infants showed rapid, or «catch-up» postnatal growth, and by age 3 month they had heights and weights similar to the controls. The IGF-1 and growth GH levels at 3 month of life in SGA infants with «catch-up» growth were higher than infants without «catch-up» growth. These results consist with an important role for IGF-1in fetal and early postnatal growth.

Key words: intrauterine growth retardation, insulin-like growth factors, growth hormone.

 

References

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13. Liu, Y.X. Risk factors for impaired length growth in early life viewed in terms of the infancy-childhood-puberty (ICP) growth model / Y.X. Liu, F. Jalil, J. Karlberg // Acta Paediatr. Scand. — 1998. — Vol. 87. — P.237—243.
14. Rost i razvitie rebenka / V.V. YUr’ev, A.S. Simahodskii, A.S. Voronovich, M.M. Homich. — SPb.: Piter, 2007. — 197 s.
15. Shabalov, N.P. Sepsis novorozhdennyh / N.P. Shabalov, D.O. Ivanov // Pediatriya. — 2003. — № 5. — S.46—56.
16. Ivanov, D.O. Narusheniya obmena glyukozy u novorozhdennyh / D.O. Ivanov // Detskaya medicina Severo-Zapada. — 2011. — T. 2, № 1. — S.68—91.
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Model of urologic treatment in newborns and infants

Marina V. Levitskaya, Ludmila B. Menovshchikova, Olga G. Mokrushina, Elena V. Yudina, Anzhelica I. Gurevich, Vasily S. Shumikhin, Alexandra S. Gurskaya

Abstract. Urologic malformations are the most wide spread pathologythat are founded in 5-14% of newborns. Thefrequencyis 6—8 casesin 1000 newborns. Among all prenatally detected defects, the kidneys and urinary system malformations is 26 to 28%.The prenatal consulting center was formed in the Filatov’s Children Hospital. The postnatal management protocol for children with urologic malformations identified prenatally was set up.The results of treatment more than 1500 patients allow recommendingthree-stage management for children with obstructive uropathy. The introduction in the perinatal urology and empowers outpatient medical record technology, allow to obtain good results of treatment and reduce the number of organ removal procedures.

Key words: urologic malformations, newborns, prenatal diagnostic, obstructive uropathy.

 

References

1. Adamenko, O.B. Prenatal’naya ul’trazvukovaya diagnostika vrozhdennyh anomalii mochevydelitel’noi sistemy / O.B. Adamenko, Z.A. Halepa, L.Yu. Kotova // Detskaya hirurgiya. — 2006. — № 1. — S.13—14.
2. Deryugina, L.A. Antenatal’naya diagnostika vrozhdennyh zabolevanii mochevyvodyaschei sistemy i obosnovaniya taktiki vedeniya detei v postnatal’nom periode: avtoref. dis. ... d-ra med. nauk / L.A. Deryugina. — M., 2008. — 64 s.
3. Kuzovleva, G.I. Klinicheskoe znachenie issledovaniya renal’noi gemodinamiki v diagnostike i lechenii obstrukcii mochevyh putei u plodov, novorozhdennyh i grudnyh detei: avtoref. dis. ... kand. med. nauk / G.I. Kuzovleva. — M., 2009.
4. Diagnosticheskii algoritm u mladencev s antenatal’no vyyavlennoi pieloektaziei / M.V. Levitskaya, L.B. Menovschikova, N.V. Golodenko [i dr.] // Detskaya hirurgiya. — 2012. — № 1. — S.7—11.
5. Gloor, J.M. Reflux and Obstructive Nephropathy / J.M. Gloor, V.E. Torres // Atlas of diseases ofthe kidney. — 2008. — Vol. 2 (8).

 

The possibility of microchimerism identifying by HLA-A, B, C, DRB1, DQB1 typing by PCR-SSP in the mothers and neonates

Natalya A. Treskina, Olga Ya. Volkova, Yury V. Petrenko, Veronica I. Smirnova, Dmitry O. Ivanov

Abstract. The article presents the possibility of microchimerism phenomenon detection in the genes of HLA loci A, B, C, DRB1, DQB1 by PCR-SSP in mothers and newborns with IUGR (11 pairs), hemolytic disease of the newborn (HDN) (9 pairs), after external rotation of the fetus (4 pairs) from women with malignancy (1 pair) and immune thrombocytopenia (1 pair). Out of 52 blood samples microchimerism was detected in 17 (33%) cases. In the group of mothers and children with HDN microchimerism was revealed in 9 (50%) samples and in the group with IUGR in 5 (23%). After the external rotation of fetus chimerism was observed in 1 (13%) case. In 2 (100%) samples of mother- child pair with autoimmune thrombocytopenia microchimerism was found in both samples, and in the couple child—mother with malignancy chimeric genes were not found. Chimeric genes were able to identify only at loci A, B, C, and DRB1 of HLA system. Chimerism in the DQB1 locus, was not observed in our samples.

Key words: microchimerism, typing for HLA system by PCR SSP.

 

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Peculiarity of methods’ application of imaging modalities used in pediatric practice

Gennady E. Trufanov, Vladimir A. Fokin, Dmitry O. Ivanov, Vladimir V. Riazanov, Victor V. Ipatov, Maria Yu. Skvortsova, Dmitry V. Nesterov, Gulnaz K. Sadykova, Ekaterina M. Mikhaylovskaya

Abstract. In this review modern considerations about pecularities of imaging modalities used in pediatric practice are presented. The main patterns of the most common pathologies of bones, central nervous system, respiratory system, gastrointestinal tract and liver, cardiovascular system and urinary tract are shown and methodical aspects of using conventional radiography, sonography, computed tomography and magnetic resonance imaging are pointed out.

Key words: conventional radiography, sonography, computed tomography and magnetic resonance imaging.

 

References

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REVIEW

Postnatal adaptation respiratory system in premature infants and correction (literature review)

Irina V. Vinogradova

Abstract. The analysis of the literature on the specifics of the respiratory system in preterm infants and methods of correction.

Key words: preterm infants, ventilation, distress of respiratory syndrome, surfactant.

 

References

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Integrated rehabilitation premature infants in the first year of life

Elena V. Volyanyuk, Asia I. Safina

Abstract. The paper presents the data in the literature on the subsequent development of premature infants, the main problems of their health and advanced features for complex rehabilitation.

Key words: preterm infants, rehabilitation activities, follow-up.

 

References

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New in the classification and diagnosis of acute kidney injury (AKI) newborn

Maria A. Daminova, Asia I. Safina, Gulia A. Khamzina

Abstract. Acute renal failure (ARF) is a serious problem in neonatal intensive care units. This pathology is often due to the critical condition of the child and in most cases there is a predisposing factor in mind. The diagnosis of acute renal failure in infants is challenging because of the specific pathophysiology of renal infants, in critical condition. The paper discusses new approaches to classification of acute kidney injury (AKI) in neonates and modern methods of early diagnosis of AKI.

Key words: newborn, acute renal failure, RIFLE, AKIN, diagnostics, classification.

 

References

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Ongenital nephrotic syndrome: etiology, diagnosis, treatment (review)

Edita K. Petrosyan

Abstract. Congenital nephrotic syndrome (CNS) is a rare kidney disorder characterized by heavy proteinuria, hypoproteinemia, and edema starting soon after birth. The majority of cases are caused by genetic defects in the components of the glomerular filtration barrier, especially nephrin and podocin. CNS may also be a part of a more generalized syndrome or caused by a perinatal infection. Immunosuppressive medication is not helpful in the genetic forms of CNS, and kidney transplantation is the only curative therapy. Before the operation, management of these infants largely depends on the magnitude of proteinuria. In severe cases, daily albumin infusions are required to prevent life-threatening edema. The therapy, also includes hypercaloric diet, thyroxin and mineral substitution, prevention of thrombotic episodes, and prompt management of infectious complications. The outcome of CNS patients without major extrarenal manifestations is comparable with other patient groups after kidney transplantation.

Key words: proteinuria, nephrotic syndrome, nephrin, podocin, kidney transplantation.

 

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Problems of breastfeeding of the premature infants

Nаdezhda L. Rybkina, Asia I. Safina

Abstract. The article is devoted to one of the urgent problems of modern neonatology — the issue of breastfeeding in the early neonatal period. We consider the problems associated with the organization of breastfeeding preterm infants born at ≥ 34 weeks' gestation. The article provides solutions to these problems and recommendations for counseling parents.

Key words: breastfeeding premature infant, initiation of breastfeeding.

 

References

1. Alferov, V.P. Pitanie detei rannego vozrasta: posobie dlya vrachei / V.P. Alferov, F.P. Romanyuk, L.N. Proida. — SPb., 2009. — 48 s.
2. Bazovaya pomosch' novorozhdennomu: mezhdunarodnyi opyt / pod red. N.N. Volodina, G.T. Suhih. — M.: GEOTAR-Media, 2008. — 208 s.
3. Bor'eson, B. Rannie otnosheniya i razvitie rebenka / B. Bor'eson, S. Britten, S.V. Dovbnya. — SPb.: Piter, 2009. — 160 s.
4. Goncharova, O.V. Kak sohranit' grudnoe vskarmlivanie, perevesti rebenka na smeshannoe / iskustvennoe vskarmlivanie ili otluchit' ot grudi / O.V. Goncharova // Consilium Medicum. Pediatriya. — 2012. — № 2. — S.15—19.
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6. Dubovich, E.G. Problemy konsul'tirovaniya roditelei s retinopatiei nedonoshennyh / E.G. Dubovich, N.V. Polunina // Praktika pediatra. — 2011. — URL: http://medi/ru/doc/j01110312/htm/
7. Osobennosti stanovleniya laktacii u materei posle prezhdevremennyh rodov / A.B. Dulenkov, YU.G. Muhina, O.V. Potapova, S.G. Gribakin // Voprosy prakticheskoi pediatrii. — 2011. — T. 6, № 3. — S.64—69.
8. Il'enko, L.I. Aktual'nye voprosy medicinskoi deontologii pri okazanii pomoschi materyam i detyam: ucheb. posobie dlya sistemy postdiplomnogo obrazovaniya / L.I. Il'enko [i dr.]. — M., 2011. — 51 s.
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11. Sovremennye tendencii problemy vskarmlivaniya nedonoshennyh detei / V.A. Skvorcova, T.E. Borovik, O.L. Lukoyanova [i dr.] // Voprosy sovremennoi pediatrii. — 2005. — T. 4, № 2. — S.80—86.
12. Tarasova, I.V. Estestvennoe vskarmlivanie novorozhdennyh / I.V. Tarasova // Medicinskaya sestra. — 2003. — № 3. — S.7.
13. The baby Friendly Hospital Initiative in neonatal units for sick and preterm newborns in Russia / E.N. Murzina, S.A. Polyanskaya, A.I. Petrov [et al.]. — Neo-BFHI, Uppsala, Sweden, 2011. — P.16—17.
14. ABM Clinical Protocol # 10: Breastfeeding the Late Preterm Infant / Breastfeeding medicine. — 2011. — Vol. 6, № 3. — P.151—156.

 

Neurodevelopmental outcomes in very-low-birth-weight infants

Elena S. Sakharova, Elena S. Keshishian, Galina A. Alyamovskaya

Abstract. This article analyzes developmental outcomes of very-low-birth-weight (VLBW) infants in first 3 years of life. More than 2 thousands infants were studied; 1920 with birth weight 1000—1500 g, 780 — with birth weight less than 1000 g (180 with 460—600 g). There were no correlations between complications in neonatal period and developmental outcomes. Many children had health and developmental problems in first years of life and needed in medical supervision in specialized follow-up centre.

Key words: premature infants, psychomotor development, follow-up system.

 

References

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Malnutrition in low birth weight infants (review)

Vera A. Skvortsova, Tatyana.E. Borovik, Olga K. Netrebenko

Abstract. An article represents the data about causes and consequences of malnutrition in low birth weight infants. Early enteral nutrition for preterm infants and ‘trophic” feed is an important possibility to improve the intestine function, gut maturation and to promote full enteral nutrition introduction. The consequences and complications of low weight gain due to low protein intake in early life are presented. The low weight gain in LBW is the cause of permanent neurological and motor development. Breast feeding of preterm LBW infants is a widely discussed topic. Human breast milk, especially mother’s milk is a source of protection and optimal digestion as well as gut comfort. The problem of breastfeeding of LBW infants is a low protein level which is not sufficient to promote optimal growth velocity. Human milk fortifiers could help to improve weight gain in LBW and prevent unfavorable side effects of protein insufficiency.

Key words: LBW, nutrition, breast milk, human milk fortifiers.

 

References

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Modern treatment of neonatal sepsis

Khalit S. Khaertynov, Marat A. Satrutdinov, Evgeniya A. Agafonova P.96

Abstract. This article presents a review of literature on the treatment of neonatal sepsis. Current approaches to treatment of sepsis include a set of measures aimed at holding causal treatment (antibiotic, antifungal), infusion and anti-inflammatory therapy, correction hemodynamic emerging, fluid and electrolyte, and metabolic disorders, providing of respiratory support, immunotherapy, correction of coagulation disorders. Some new perspectives of treatment of neonatal sepsis.

Key words: newborn, sepsis, treatment.

 

References

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23. Carr, R. G-CSF and GM-CSF for treating or preventing neonatal infections / R. Carr, N. Modi, C. Dore // Cochrane Database Syst. Rev. — 2003. — Vol. 3. — CD003066.
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28. Effect of the immunomodulating agent, pentoxifylline, in the treatment of sepsis in prematurely delivered infants: A placebocontrolled, double-blind trial / R. Lauterbach, D. Pawlik, D. Kowalczyk [et al.] // Crit. Care Med. — 1999. — № 27. — P.807—814.
29. Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab′)2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels / E.A. Panacek, J.C. Marshall, T.E. Albertson [et al.] // Crit. Care Medicine. — 2004. — № 32 (11). — P.2173—2182.
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37. Laupland, K.B. Polyclonal intravenous immunoglobulin for the treatment of severe sepsis and septic shock in critically ill adults: a systematic review and meta-analysis / K.B. Laupland, A.W. Kirkpatrick, A. Delaney // Crit. Care Med. — 2007. — № 35 (12) — P.2686—2692.
38. Low serum cortisol in combination with high adrenocorticotrophic hormone concentrations are associated with poor outcome in children with severe meningococcal disease / E.D. De Kleijn, K.F. Joosten, B. Van Rijn [et al.] // Ped. Infect. Dis. J. — 2002. — № 21. — P.330—336.
39. Management of neonates with suspected or proven early-onset bacterial sepsis / R.A. Polin and the committee on fetus and newborn // Pediatrics. — 2012. — № 129. — P.1006.
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49. Treatment of neonatal sepsis with intravenous immune globulin / P. Brocklehurst, B. Farrell, A. King [et al.] // N. Engl. J. Med. — 2011. — № 365 (13). — P.1201—1211.
50. Use of polyclonal immunoglobulin’s as adjunctive therapy for sepsis or septic shock / K.G. Kreymann, G. de Heer, A. Nierhaus, S. Kluge // Crit. Care Med. — 2007. — № 35. — P.2677—2685.

 

CLINICAL LECTURE

Neonatal thrombocytopenia

Ilnur I. Zakirov, Asia I. Safina

Abstract. The article describes the clinical aspects of thrombocytopenia in neonates. The scheme of diagnostic search reasons for the decline of platelets in the blood. Considered the most frequent nosologic forms of thrombocytopenia in the neonatal period and therapeutic approaches tactics.

Key words: newborns, thrombocytopenia.

 

References

1. Barkagan, Z.S. Gemorragicheskie zabolevaniya i sindromy / Z.S. Barkagan. — M.: Medicina, 1988. — 528 s.
2. Vasilevskii, I.V. Vtorichnye (simptomaticheskie) trombocitopenii u detei i podrostkov / I.V. Vasilevskii // Medicinskaya panorama. — 2009. — № 4. — S.5—10.
3. Golovko, O.K. Klinicheskie aspekty immunnyh trombocitopenii v neonatologii / O.K. Golovko, G.L. Linchevskii, O.V. Vorob'eva // Zdorov'e rebenka. — 2006. — № 2. — S.115—122.
4. Zhiburt, E. Perelivanie trombocitov detyam / E. Zhiburt, S. Madzaev // Medicinskaya gazeta. — 2013. — № 65. — S.8—9.
5. Maschan, A.A. Immunno-oposredovannye trombocitopenii novorozhdennyh: differencial'nyi diagnoz i principy terapii / A.A. Maschan, A.G. Rumyancev // Voprosy gematologii/onkologii i immunopatologii v pediatrii. — 2010. — T. 9, № 3. — S.13—18.
6. Pshenichnaya, K.I. Vrozhdennye trombocitopatii u detei: osobennosti diagnostiki, simptomatiki i lecheniya: avtoref. dis. ... kand. med. nauk / K.I. Pshenichnaya. — SPb., 2002. — 28 s.
7. Rooz, R. Neonatologiya: prakt. rekomendacii: per. s nem. / R. Rooz. — M.: Medicinskaya literatura, 2011. — 59 s.
8. Shabalov, N.P. Neonatologiya: ucheb. posobie / N.P. Shabalov. — M.: MEDpress-inform, 2004. — 640 s.
9. Blanchette, V.S. Platelet disorders in newborn infants: diagnosis and management / V.S. Blanchette, M.L. Rand // Semin Perinatol. — 1997. — № 21. — Р.53—62.
10. Bussel, J.B. Immune thrombocytopenia in pregnancy: autoimmune and alloimmune / J.B. Bussel // J. Reprod. Immunol. — 1997. — № 37. — Р.35—61.
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13. Letsky, E.A. Guidelines on the investigation and management of thrombocytopenia in pregnancy and neonatal alloimmune thrombocytopenia. Material and Neonatal Haemostasis Working Party of the Haemostasis and Thrombosis Task Force of the British Society for Haematology / E.A. Letsky, M. Greaves // Br. J. Haematol. — 1996. — № 95 (1). — Р.21—26.
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16. Roberts, I.G. Management of thromobocytopenia in neonates. Archives of Diseases in Childhood / I.G. Roberts, N.A. Murray // Fetal and Neonatal Edition. — 2003. — № 88. — Р.359—364.

 

The interpretation of ECG in the practice of neonatology

Ildus Ya. Lutfullin, Asia I. Safina, Zulfia R. Dolgova

Abstract.The articleis devoted tothe basic principlesof clinical interpretationof the electrocardiogramof the newbornchild, adopted in international practice. We describethe clinicaland instrumentalalgorithmsof differential diagnosisof arrhythmias innewborns, the possible causes, and the follow-up ofinfants withabnormalitieson ECG.

Key words: electrocardiography, newborns, arrhythmia, differential diagnosis.

 

References

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5. Are gender differences in QTc present at birth? MISNES Investigators. Multicenter Italian Study on Neonatal Electrocardiography and Sudden Infant Death Syndrome / M. Stramba-Badiale, D. Spagnolo, G. Bosi, PJ. Schwartz // Am. J. Cardiol. — 1995. — № 75. — P.1277—1278.
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7. Prenatal findings in patients with prolonged QT interval in the neonatal period / M. Hofbeck, H. Ulmer, E. Beinder [et al.] // Heart. — 1997. — № 77. — P.198—204.
8. Belozerov, Yu.M. Detskaya kardiologiya: nauchnoe izdanie / Yu.M. Belozerov. — M.: MEDpress-inform, 2004. — 597 s.
9. Makarov, L.M. Normativnye parametry EKG u detei / L.M. Makarov, I.I. Kiseleva, V.V. Dolgih [i dr.] // Pediatriya. — 2006. — № 2. — S.4—12.
10. Prahov, A.V. Neonatal'naya kardiologiya / A.V. Prahov. — N.Novgorod: NGMA, 2008. — 388 s.
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12. Perry, J.C. Supraventricular tachycardia due to Wolff—Parkinson—White syndrome in children: early disappearance and late recurrence / J.C. Perry, A. Garson // J. Am. Coll. Cardiol. — 1990. — № 16. — P.1215—1220.
13. Deal, B.J. Wolff—Parkinson—White syndrome and supraventricular tachycardia during infancy: management and follow-up / B.J. Deal, J.F. Keane, P.C. Gillette, A. Garson // J. Am. Coll. Cardiol. — 1985. — № 5. — P.130—135.
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16. Schwartz, P.J. The long QT syndrome // Cardiac electrophysiology: from cell to bedside / P.J. Schwartz, S.G. Priori, C. Napolitano; D.P. Zipes, J. Jalife eds. — 3rd edn. — Philadelphia: WB Saunders, 2000. — P.597— 615.

 

Osteopenia of prematurity

Аsiya I. Safina

Abstract. Premature babies have a higher risk of reduced bone density and osteopenia. In the present lecture highlights the issues in the pathophysiology of osteopenia of prematurity, are considered risk factors for its development, an algorithm for the diagnosis, treatment and prevention of disease.

Key words: osteopenia, premature, infants.

 

References

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6. Johnson, C.B. Neonatal rickets: metabolic bone disease of prematurity / C.B. Johnson // Neonatal. Netw. — 1991. — Vol. 9. — Р.13—17.
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8. Enteral calcium, phosphate and vitamin D requirements and bone mineralization in preterm infants / J. Rigo [et al.] // Acta Paediatr. — 2007. — Vol. 96. — Р.969—974.
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Pattern of pathogenesis, diagnostics and treatment of urinary tract infections in newborn and infancy, feasibility of therapeutics

Olga L. Chugunova, Marina V. Shumikhina, Svetlana V. Dumova, Anna S. Foktova

Abstract. This paper is about pathogenesis, diagnostics and special aspects of clinical progression of urinary tract infection (UTI) in newborn and infants. Therapeutic treatment and prophylactics of recurrences of infection described detailed. Value of cellular power intercharge and progression of nephrosclerosis in children with recurrent UTI has marked, that is why including of anabolic and antisclerotic together with antibiotic medications is necessary.

Key words: urinary tract infection, newborn, children, treatment.

 

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29. Warady, B.A. Chronic kidney disease in children: the global perspective / B.A. Warady, V. Chadha // Pediatric Nephrology. — 2007. — Vol. 22. — P.1199—2009.
30. Practice Parameter: The Diagnosis, Treatment, and Evaluation of the Initial Urinary Tract Infection in Febrile Infants and Young Children. American Academy of Pediatrics. Committee on Quality Improvement, Subcommittee on Urinary Tract Infection / D.A. Bergman, R.D. Baltz, J.R. Cooley [et al.] // Pediatrics. — 1999. — Vol. 103 (4). — Р.843—852.
31. Tabolin, V.A. Sovremennoe sostoyanie voprosa perina- tal’noi i neonatal’noi patologii pochek / V.A. Tabolin, I.N. Kuchinskii // Zabolevaniya pochek u detei rannego vozrasta: sb. «Trudy II MOLGMI-1980». — 1980. — T. CLVI, vyp. 31. — S.9—19. — (Ser. Pediatriya).
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33. American Academy of Pediatrics: Section on Urology Response to New Guidelines for the Diagnosis and Management of UTI. — Pediatrics. — March, 2012. —URL: http://pediatrics.aappublications.org/site/misc/reprints.xhtml
34. Ul’trazvukovoe issledovanie pochek pri puzyrno-mochetochnikovom reflyukse u detei / E.B. Ol’hova, E.M. Kopylova, O.A. Paches, S.Yu. Nikitina // Ehografiya. — 2001. — № 2 (2). — S.201—211.
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Perinatal comprehensive strategy for management of neonatal respiratory distress syndrome in preterm infants: basic points of the European consensus. 2013 update

Olga A. Stepanova, Asia I. Safina

Abstract. The lecture discusses the main aspects of the management of neonatal respiratory distress syndrome in preterm infants of the according to the European Consensus Guidelines — 2013 Update.

Key words: prematurity, respiratory distress syndrome, prenatal care, delivery room stabilization, surfactant therapy, respiratory support.

 

References

1. Vauer, R. Surfaktant v neonatologii. Profilaktika i lechenie respiratornogo distress-sindroma novorozhdennyh: per s nem. / R. Vauer. — M.: Med lit., 2011. — 192 c.
2. Volodin, N.N. Prakticheskie voprosy profilakticheskoi perinatologii v Rossiiskoi Federacii / N.N. Volodin // Rossiiskii vestnik perinatologii i pediatrii. — 2003. — № 4. — S.4—7.
3. Grebennikov, V.A. Respiratornyi distress-sindrom u novorozhdennyh / V.A. Grebennikov, O.B. Milenin, I.I. Ryumina. — M.: Vestnik mediciny, 1995. — 136 s.
4. Degtyareva, M.V. Obzor osnovnyh polozhenii Evropeiskogo konsensusa po taktike vedeniya respiratornogo distress-sindroma u nedonoshennyh novorozhdennyh detei. Peresmotr 2010 goda / M.V. Degtyareva, V.A. Grebennikov, N.N. Volodin // Voprosy prakticheskoi pediatrii. — 2011. — № 3. — S.103—108.
5. Luchevaya diagnostika. Detskie bolezni: per. s angl. / G. SHtaatc, D. Honnef, V. Pirot, T. Radkov; pod red. prof. T.A. Ahadova. — M.: MEDpress-inform, 2010. — 400 s.
6. Nedonoshennost': per. s angl. Dzh. Lamli, E. Raie, G. Dzhenkin [i dr.] / V.H. Viktor [i dr.]; pod red. V.H. Viktora, E.K. Vuda. — M.: Medicina, 1991. — 368 s.
7. Neonatologiya: nacional'noe rukovodstvo / pod red. N.N. Volodina. — M.: GEOTAR-Media, 2009. — 849 s.
8. Pervichnaya i reanimacionnaya pomosch' novorozhdennym detyam [Elektronnyi resurs]: metod. pis'mo Minzdravsocrazvitiya RF ot 21 aprelya 2010 g. № 15-4/10/2-3204 // Spravochno-pravovaya sistema «Konsul'tant Plyus».
9. Perinatal'nyi audit pri prezhdevremennyh rodah / E.M. Vihlyaeva [i dr.]; pod red. V.I. Kulakova. — M., 2005. — 245 c.
10. Principy vedeniya novorozhdennyh s respiratornym distress-sindromom: metod. rekomendacii / pod red. N.N. Volodina. — M., 2002. — 69 s.
11. Emmanuilidis, G.K. Serdechno-legochnoi distress u novorozhdennyh: monografiya / G.K. Emmanuilidis, B.G. Bailen; per. s angl. D.V. Nebieridze, L.D. Mochalovoi. — M.: Medicina, 1994. — 400 c.
12. European Consensus Guidelines on the Management of Neonatal Respiratory Distress Syndrome in Preterm Infants — 2013 Update / D.G. Sweet, V. Carnielli, G. Greisen, M. Hallman [et al.] // Neonatology. — 2013. — № 103. — P.353—368.
13. Crowley, P. The effects of corticosteroid administration before preterm delivery: an overview of the evidence from controlled trials / P. Crowley, I. Chalmers, M. Keirse // BJOG. — 1990. — Vol. 97. — P.11—25.
14. Yost, C.C. Early versus delayed selective surfactant treatment for neonatal respiratory distress syndrome (Cochrane Review) / C.C. Yost, R.F. Soll. — Cochrane Database Syst Rev., 2000. — CD001456.

 

WHEN THE ISSUE WAS IN PRINT

Рarameteres of quasi-attractors of women with endometriosis at hirudoreflexotherapy

Raise N. Zhivoglyad, Alexey G. Danilov, Olga A. Bondarenko, Natalia V. Zhivaeva

Abstract. The aim of researching — to analyze the parameters of quasi-attractors of vector of body's state of women with endometriosis before and after hirudorefleksotherapy and also to identify the features of the chaotic dynamics of the behavior of the parameters autonomic and cardiorespiratory systems in hirudorefleksotherapy. Material and methods. 30 women were been treated, the degree of activity of autonomic nervous system assessed according due to heart rate variability before and after treatment.Results and discussion. It was found out that after course of regenerative treatment parameters of quasi-attractors changed and vector of human body's state (VHBS ) moved from the attractor pathology into sanogenesis attractor.Conclusion.Methods of rehabilitation therapy based on hirudorefleksotherapy for patients ill by endometriosis give an opportunity to control the parameters of homeostasis, with recovering of internal genital organs and normalization of patrologically changed tissues.

Key words: hirudoreflexotherapy, vector of human body's state, phase spaces.

 

References

1. Adamyan, L.V. Endometriozy: rukovodstvo dlya vrachei / L.V. Adamyan, V.I. Kulakov, E.N. Andreeva. — M.: Medicina, 2006. — 416 s.
2. Baskakov, V.P. Endometrioidnaya bolezn’ / V.P. Baskakov, YU.V. Cvelev, E.F. Kira. — SP.: OOO «Izdatel’stvo N-L», 2004. — 452 s.
3. Vahmina, Yu.V. Modeli slozhnyh sistem s pozicii fiziki i teorii haosa-samoorganizacii — Surgut, Tula, Gannover, Vashington / Yu.V. Vahmina, T.V. Gavrilenko, A.A. Baltikova // Slozhnost’. Razum. Postneklassika. — 2013. — № 1. — S.51.
4. Zhivoglyad, R.N. Girudoterapiya i vosstanovitel’naya medicina: monografiya / R.N. Zhivoglyad; Surgutskii GU HMAO-YUgry. — Surgut: Izdatel’stvo OOO «Taimer», 2012. — 237 s.
5. Filatov, M.A. Metod matric mezhattraktornyh rasstoyanii v identifikacii psihofiziologicheskih funkcii cheloveka — Surgut, Tula, Gannover, Vashington / M.A. Filatov, D.Yu. Filatova, O.I. Himikova, Yu.V. Romanova // Slozhnost’. Razum. Postneklassika. — 2012. — № 1 — S.86—94.
6. Filatova, O.E. Neopredelennost’ i neprognoziruemost’ — bazovye svoistva sistem v biomedicine — Surgut, Tula, Gannover, Vashington / O.E. Filatova, D.Yu. Filatova, A.A. Hadarcev // Slozhnost’. Razum. Postneklassika. — 2012. — № 1 — S.68.
7. Eskov, V.M. Measurement of the dynamic parameters of microchaos in the behavior of living biosystems / V.M. Eskov, T.V. Gavrilenko, V.V. Kozlova, M.A. Filatov // Measurement Techniques. — 2012. — Vol. 55 (9). — P.1096—1100.
8. Eskov, V.M. Two types of systems and three types of paradigms in systems philosophy and system science / V.M. Eskov, V.V. Eskov, O.E. Filatova, M.A. Filatov // Journal of Biomedical Science and Engineering. — 2012. — Vol. 5, № 10. — P.602—607.
9. Eskov, V.M. Quantitative Registration of the Degree of the Voluntariness and Involuntariness (of the chaos) in Biomedical Systems / V.M. Eskov, A.A. Khadartsev, V.V. Eskov, O.E. Filatova // Journal of Analytical Sciences Methods and Instrumentation. — 2013. — Vol. 3. — P.67—74.