Vol. 6 Issue 4 (2013)

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ORIGINAL ARTICLES

Comparative research of influence of substances of C14 and C16 possessing antibacterial and fungicide action on cellular permeability at persons of different quartiles of NA+-LI+- countertransport. O.V. Orlova, V.N. Oslopov, S.A. Sidullina P.5

Current schemes infusion-detoxification in addiction. Issues its quality assurance. A.Yu. Sidullin, S.N. Egorova, V.N. Oslopov P.9

Estimation of the cellular part of immunity and its interrelation with the cytolytic syndrome at the chronic virus hepatites вat children. O.V. Churbakova P.14

NOD2/CARD15 and TNF-α gene polymorphism in patients with ulcerative colitis in Ryazan region. A.G. Yakubovskaya, А.A. Nizov, V.S. Baranov, Ju.A. Nasykhova, T.E. Ivashchenko P.17

Study of the quality of life of patients with COPD in conjunction with the use in CHF SF-36. E.B. Frolova, M.F. Yaushev P.21

Structural analysis of mortality of community-acquired pneumonia patients admitted to hospitals of the Tatrstan Republic in 2012. R.I. Shaymuratov, G.V. Lysenko, A.A. Vizel P.25

The identification of options interleukin 28b gene polymorphism as a predictor of effective antiviral therapy for chronic hepatitis C. V.Кh. Fazulov, S.V. Tkacheva, E.R. Manapova, Ju.M. Sozinova P.30

Features hypertrophy of left ventricular and varia-tions remodeling myocardium in patients with hypertensive nephropathy. O.N. Sigitova, E.I. Saubanova P.33

ORGANIZATION OF HEALTHCARE

Calculation of indirect costs of pneumonia in the Samara region. O.D. Sivakova P.38

Estimation of quality of cardiological aid in public health services modernization. E.А. Atsel P.42

EXCHANGE OF EXPERIENCE

Ways of prediction disability in police officers. A.A. Kulakova, S.V. Smolyaninov P.46

Experience of coccygodynia treatment. I.M. Fatkhutdinov P.49

ECG findings in apical left ventricular hypertrophy. L.Kh. Safargalieva, N.A. Mukhametzyanova, N.B. Amirov, L.F. Baybulatova, G.V. Tukhvatullina P.52

Acute myocarditis in practis of doctor (a clinical case). G.A. Mukhametshina, N.B. Amirov, E.B. Frolova, F.F. Agliullina, N.A. Mukhametzyanova, A.A. Morozova P.58

Video-digital system on the basis of «Expert-Lab» for automatic registration of the results of the immune blotting for the diagnosis of syphilis. S.G. Mardanly, A.E. Tugolukov, T.A. Starovoytova, A.S. Avdo-nina, O.I. Kirdanovskaya, Ju.Ju. Vengerov P.63

To a question on pulmonary artery thromboembolism. G.A. Mukhametshina, N.B. Amirov, E.B. Frolova, O.Ju. Mikhoparova, O.Yu. Dmitriev, M.S. Spiridonova P.68

REVIEW

Peculiarity of coronary lesions in patients with silent myocardial ischemia. S.D. Mayanskaya, D.R. Tavkaeva P.74

Positive inotropic agents for treatment of acute heart failure. S.D. Mayanskaya P.80

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ORIGINAL ARTICLES

PDF downloadComparative research of influence of substances of C14 and C16 possessing antibacterial and fungicide action on cellular permeability at persons of different quartiles of NA+-LI+- countertransport

Olga V. Orlova, Vladimir N. Oslopov, Svetlana A. Sidullina

Abstract. Research objective – comparative studying of influence new biologically active substances of C14
(triphenyltetradecylphosphonium bromide) and C16 (tributilgeksadecylphosphonium bromide) on permeability of
membranes of cages on Na+ by determination of speed of Na+-Li+-countertransport in an erythrocyte membrane from a position of its various initial condition. On the basis of the obtained data biologically active agent choice for creation of a medicinal form with antibacterial, fungicide action, the most effective for individuals of I, III and IV quartiles of speed of Na+-Li+-countertransport will be carried out. Methods. Blood of 15 healthy volunteers with various quartile distribution of speed of Na+-Li+-countertransport in an erythrocyte membrane is investigated: The I quartile (5 people) – low permeability, the III quartile (5 people) – moderately high, the IV quartile (5 people) – high permeability. Results. On investigated, belonging to the I quartile of speed of Na+-Li+-countertransport, С14 has no impact on permeability of membranes of erythrocytes on Na+, and at C16 introduction in concentration of 0,001 and 0,005 .M permeability increase on Na+ is noted; faces of the III quartile have Na+-Li+-countertransport of C14 and C16 in doses of 0,001 and 0,005 .M increase permeability of membranes of erythrocytes on Na+. At investigated, belonging to the IV quartile of speed of Na+-Li+-countertransport, biologically active agent С14 in a dose of 0,05 .M reduces permeability of membranes of erythrocytes at biologically active agent С16 in concentration of 0,001 and 0,005 .M permeability increase on Na+ is noted. It testifies that the substance C16 will be more effective as medicinal substance. Conclusions. Change of permeability of a cellular membrane on sodium under the influence of substances of C14 and C16 depends on the initial genetically determined condition of a cellular membrane.

Key words: erythrocyte membrane permeability, triphenyltetradecylphosphonium bromide,  tributilgeksadecylphosphonium bromide, Na+-Li+-countertransport.

 

References

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  4. Oslopov, V.N. Klinicheskoe znachenie opredeleniya iontransportnyh funkcii kletochnyh membran pri gipertonicheskoi bolezni i ee cerebral'nyh oslozhneniyah / V.N. Oslopov, A.T. Zabbarova, E.I. Bogdanov // Kazan. med. zhurnal. – 2000. – T. XXXI, № 3. – S. 211–215.
  5. Oslopov, V.N. Skorost' natrievo-litievogo protivotransporta v membrane eritrocita u chasto boleyuschih detei / V.N. Oslopov, O.I. Pikuza, H.M. Vahitov, A.A. Korablyova // Pediatriya. – 2006. – № 3. – S. 21–24.
  6. Orlova, O.V. Vliyanie novyh sintezirovannyh veschestv S10, S12, S14, S16, S18 na pronicaemost' kletochnyh membran dlya ionov natriya v modeli in vitro / O.V. Orlova, V.N. Oslopov, S.A. Sidullina // Kazan. med. zhurnal. – 2012. – T. XCIII, № 3. – S. 505–507.
  7. Orlova, O.V. Vliyanie trifeniltetradecilfosfoniya bromida na skorost' Na+-Li+-protivotransporta v membrane eritrocita u pacientov s geneticheski razlichnoi pronicaemost'yu membran po natriyu / O.V. Orlova, V.N. Oslopov, S.A. Sidullina // Kazan. med. zhurnal. – 2012. – T. XCIV, № 5. – S. 789–791.
  8. Ovchinnikova, L.K. O vzaimodeistvii lekarstvennyh sredstv (chast' II) / L.K. Ovchinnikova, R.I. Yagudina // Rossiiskie apteki. – 2006. – № 11/1. – S. 26–27.
  9. Orlova, O.V. Issledovanie vliyaniya dimetilsul'foksida na pronicaemost' kletochnyh membran / O.V. Orlova, S.N. Egorova, V.N. Oslopov // Kazan. med. zhurnal. – 2011. – T. XCII, № 6. – S. 901–904.
  10. Postnov, Yu.V. Pervichnaya gipertenziya kak patologiya kletochnyh membran / Yu.V. Postnov, S.N. Orlov. – M.: Medicina, 1987. – 192 s.
  11. Fetal mouse skin heals scarlessly in a chick chorioallantoic membrane model system. – Carre AL – Ann Plast Surg – 01-JUL-2012; 69(1): 85-90 (MEDLINE® is the source for the citation and abstract of this record).
  12. The oxidative damage of butenolide to isolated erythrocyte membranes. – Wang YM – Toxicol In Vitro – 01-AUG-2007; 21(5): 863-9 (MEDLINE® is the source for the citation and abstract of this record).

 

PDF downloadCurrent schemes infusion-detoxification in addiction. Issues its quality assurance

Anton Yu. Sidullin, Svetlana N. Egorova, Vladimir N. Oslopov

Abstract. Aim. To study cited in the literature schemes infusion-detoxification therapy and the use of new drugs in
addiction. Identify the role of combination therapy in treatment regimens examined. Based on the analysis of the data to evaluate the possibility of incompatibility pharmaceutical drugs and its consequences, it is necessary to ensure the quality and effectiveness of combination therapy introduction of new developments in the medical practice of substance abuse hospitals. Material and methods. The literature on the modernization of infusion-detoxification therapy, the use of new drugs and the proportion of combination therapy in the treatment of substance abuse patients. Profiles of pharmacists, doctors and nurses, and drug toxicology departments of hospitals. 35 questions answered questionnaires 26 pharmacists, 23 physicians (drug treatment, resuscitation) and 51 nurse. Results. It was revealed that the schemes infusion-detoxification upgraded, new drugs are used, which is reflected in the current scientific literature. Significant role in the described combination therapy regimens. Combination therapy does not preclude the pharmaceutical drug incompatibility. Cycles necessary to carry out improvements on the pharmaceutical incompatibility, increasing the availability of information and changing approaches to quality control in combination therapy. Conclusion. Identification of pharmaceutical incompatibility drug regimens of patients is required to ensure the quality of the combined infusion-detoxification and effectiveness of the implementation of new medical developments.

Key words: infusion-detoxification therapy, drug incompatibility, combined therapy.

 

References

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PDF downloadEstimation of the cellular part of immunity and its interrelation with the cytolytic syndrome at the chronic virus hepatites B in children

Olga V. Churbakova

Abstract. In clause – the immune factors influencing on pathogenesis of the Chronic Virus Hepatites B at children in the replicative phase are considered. Clinical supervision and researches with application general-clinical, biochemical, tool, the immunological methods have been spent, allowing to receive the fullest and objective information on the observable children sick CVHВ. Were the cellular part of immunity at children before treatment and after carrying out of therapy and its correlation communications with cytolysis is studied. Dependence of the cellular part of immunity and the cytolytic syndrome is revealed. The deviation of immunological parameters in whey of blood of patients with CVHВ from normal parameters is the indicator of activity of the Chronic Virus Hepatites.

Key words: a Chronic Virus Hepatites, replicative a phase, cytolysis.

 

References

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  5. Radchenko, V.G. Osnovy klinicheskoi gepatologii. Zabolevaniya pecheni i biliarnoi sistemy / V.G. Radchenko, A.V. Shabrov, E.N. Zinov'eva. – SPb.: Izd-vo «Dialekt»; M., 2005. – S. 191–194.
  6. Romancov, M.G. Sovremennyi podhod k adekvatnoi terapii hronicheskih gepatitov. Effektivnost' etiotropnoi i patogeneticheskoi terapii, ocenka kachestva zhizni, risk razvitiya ishodov zabolevaniya / M.G. Romancov, T.V. Sologub, L.G. Goryacheva. – SPb.: Izd-vo «Taktik- Studio», 2010. – 64 s.
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PDF downloadNOD2/CARD15 and TNF-α gene polymorphism in patients with ulcerative colitis in Ryazan region

Alina G. Yakubovskaya, Аleksey A. Nizov, Vladislav S. Baranov, Julia A. Nasykhova, Tatiana E. Ivashchenko

Abstract. Aim. To investigate polymorphic variants of TNF-α and NOD2/CARD15 genes in patients with ulcerative colitis (UC) living in Ryazan region and their association with clinical picture of UC and response to treatment. Material and methods. 50 patients were tested, polymorphic variants of TNF-α (-238G/A и-308G/A) and NOD2/CARD15 (Arg702Trp, Gly908Arg, Leu3020insC) genes were analyzed. Results. Frequency of genotypes and alleles of the genes don’t differ significantly in UC patients and population study. An earlier onset (р=0,01) and more frequent UC exacerbations (in 1,63) is revealed in -308 А allele TNF-α gene carriers. Conclusion. Allele -308А of TNF-α gene is associated with a more severe course of the disease so a more intensive basic treatment and a thorough monitoring of patients’ condition is required.

Key words: ulcerative colitis, NOD2/CARD15 gene, TNF-α gene.

 

References

  1. Analiz polimorfizma genov NOD2/ CARD15 i TNF-α u pacientov s hronicheskimi vospalitel'nymi zabolevaniyami zheludochno-kishechnogo trakta / Yu.A. Nasyhova [i dr.] // Molekulyarnaya medicina. – 2010. – № 3. – S. 32–37.
  2. Valuiskih, E.Yu. Vliyanie geneticheskih i sredovyh faktorov na klinicheskie proyavleniya hronicheskih vospalitel'nyh zabolevanii kishechnika (bolezn' Krona i nespecificheskii yazvennyi kolit): avtoref. dis. ... kand. med. nauk / E.Yu. Valuiskih. – Novosibirsk, 2012. – 32 s.
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  4. Nespecificheskie vospalitel'nye zabolevaniya kishechnika / pod red. G.I. Vorob'eva, I.L. Halifa. – M.: Miklosh, 2008. – 400 s.
  5. Polimorfizm genov NOD2/CARD15, OCTN1 i OCTN2 u detei s bolezn'yu Krona i yazvennym kolitom / P.V. SHumilov [i dr.] // Lechenie i profilaktika. – 2011. – № 1. – S. 16–21.
  6. Cho, J.H. The genetics of inflammatory bowel disease / J.H. Cho, C.T. Weaver // Gastroenterology. – 2007. – Vol. 133. – Р. 1327–1339.

 

PDF downloadStudy of the quality of life of patients with COPD in conjunction with the use in CHF SF-36

Elvira B. Frolova, Marat F. Yaushev

Abstract. The abstract is the study of the quality of life in patients with COPD and CHF on the basis of Quality of Life Questionnaire. SF-36 questionnaire (English The Short Form-36) – is a non-specific questionnaire for assessing quality of life of the patient, is widely used in studies of quality of life. The survey reflects the general well-being and satisfaction with those aspects of human life that are affected by the state of health. SF-36 consists of 36 questions grouped into eight scales: physical functioning, role activities, bodily pain, general health, vitality, social functioning, emotional and mental state of health. Performance of each scale so constituted that the higher value of the exponent (0 to 100) the best estimate of the chosen scale. Of them form two parameters: the psychological and physical components of health.

Key words: SF-36 questionnaire, CHF, COPD.

 

References

  1. Chuchalin, A.G. Kachestvo zhizni pacientov s hronicheskoi obstruktivnoi bolezn'yu legkih: mozhem li my ozhidat' bol'shego? (Rezul'taty nacional'nogo issledovaniya IKAR-HOBL) / A.G. Chuchalin [i dr.] // Pul'monologiya. – 2006. –№ 5. – S. 19–27.
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PDF downloadStructural analysis of mortality of community-acquired pneumonia patients admitted to hospitals of the Tatrstan Republic in 2012

Rustem I. Shaymuratov, Galina V. Lysenko, Alexander A. Vizel

Abstract. Objective: To examine the characteristics of patients admitted to the hospitals of the Republic of Tatarstan died from community-acquired pneumonia in 2012. To draw conclusions about the factors that influences the development of death. Material and methods. Type of study: a retrospective, observational, an object of analysis — in-patient medical charts. Results. 160 death cases of patients older than 18 years admitted to hospitals of the Republic of Tatarstan were analyzed. Age of the deceased at the time of admission to hospital ranged from 21 to 90 years (56,98 ± 16,506), 69,4% men, 30,6% women. Conclusion. In the structure of mortality prevalence of males of working age dominated. Underestimation of the severity of the condition was present on admission, which manifests itself in later transfer to the ICU, only two thirds of patients had evaluated saturation. During hospitalization some discrepancies were found: such as insufficiency initial evaluation of patients who died from the CAP, rare appointment lateral projection X-ray assessments, microscopy and bacteriological analysis of sputum.

Key words: community-acquired pneumonia, mortality, hospital patients.

 

References

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  4. Gil’manov, A.A. Analiz effektivnosti lecheniya i prichin letal’nyh ishodov pri vnebol’nichnoi pnevmonii v Respublike Tatarstan // A.A. Gil’manov, A.A. Vizel’, I.Yu. Malysheva [i dr.] // Problemy tuberkuleza. — 2002. — № 7. — S.26—30.
  5. Menendez, R. Risk factors of treatment failure in community acquired pneumonia: implications for disease outcome / R. Menendez, A. Torres, R. Zalacain [et al.] // Thorax. — 2004. — Vol. 59. — P.960—965.
  6. Hamitov, R.F. Narkozavisimost’ i infekcionnaya patologiya: kliniko-immunologicheskie aspekty (obzor literatury) // R.F. Hamitov, I.G. Mustafin, O.L. Paikova // Vestnik sovremennoi klinicheskoi mediciny. — 2009. — T. 2, № 3. — S.54—59.

 

PDF downloadThe identification of options interleukin 28b gene polymorphism as a predictor of effective antiviral therapy for chronic hepatitis C

Vildan Кh. Fazulov, Svetlana V. Tkacheva, Elvira R. Manapova, Julia M. Sozinova

Abstract. The induction method for introducing of standard interferon-α (IFN-α) in combination with ribavirin in patients with chronic hepatitis C (CHC), although it does not apply to current international standards, is often used in the practice of medicine. The search of predictors antiviral therapy is conducted in recent years. Polymorphism rs12979860 and rs8099917 gene interleukin-28B (IL-28B) has a significant effect on the frequency of achieving sustained virological response (SVR) in the treatment with pegylated interferon. The aim of this study — to evaluate the effectiveness of the inductive method of introduction of IFN-α during combination antiviral therapy of CHC based on the patients IL-28B genotyping. Material and methods. We observed 89 patients with CHC treated with IFN-. in the induction mode in combination with ribavirin, lasting 24-48 weeks. Identification of single nucleotide polymorphisms (PEN) in rs12979860 and rs8099917 locus gene IL-28B was conducted in 29 patients using the «AmpliSens Genoscreen — IL 28V-FL» reagent kit in the viral hepatitis laboratory of the molecular diagnostic department. Results. SVR at week 24 of follow-up was achieved in 70,8% of treated patients. Genotypes rs12979860 CC and rs8099917 TT of IL-28B gene in a group of patients responding to treatment reported in 40 and 60%, respectively. In patients with HCV genotype 1 (HCV-1) the maximum frequency of virologic response rates were reported for patients with rs12979860 CC and rs8099917 TT (SVR — 83,3 and 54,5% respectively). Conclusion. Predictor of efficiency the inductive method of the use IFN-α with ribavirin for antiviral treatment CHC in patients with HCV-1 genotypes are CC rs12979860 and rs8099917 TT by IL-28B.

Key words: hepatitis C, the gene IL-28B, antiviral therapy, interferon-α, ribavirin.

 

References

  1. Abdurahmanov, D.T. Protivovirusnaya terapiya hronicheskogo gepatita S: etapy razvitiya / D.T. Abdurahmanov // Klinicheskaya gepatologiya. — 2009. — № 2. — S.26—33.
  2. Moiseev, S.V. Lechenie hronicheskogo gepatita S: rezul’taty randomizirovannyh kontroliruemyh issledovanii / S.V. Moiseev // Infekcionnye bolezni. — 2010. — T. 8, № 3. — S.52—57.
  3. Enaleeva, D.Sh. Hronicheskie virusnye gepatity V, S i D / D.Sh. Enaleeva, V.H. Fazylov, A.S. Sozinov. — M.: Medpress-inform. — 2011. — 463 s.
  4. Nikitin, I.G. Chelovecheskii leikocitarnyi al’fa-interferon v kombinirovannoi terapii bol’nyh hronicheskim gepatitom S, inficirovannyh ne 1-m genotipom virusa/ I.G. Nikitin, L.M. Gogova, I.E. Baikova [i dr.] // Klinicheskie perspektivy gastroenterologii i gepatologii. — 2009. — № 1. — S.33—37.
  5. Genetic factors and hepatitis C virus infection/ A.J. Thompson // Gastroenterology. — 2012. — Vol. 142. — P.1335—1339.
  6. Kozina, A.N. Vozmozhnosti personificirovannogo podhoda k lecheniyu gepatita S na osnovanii razrabotannyh geneticheskih testov opredeleniya varianta polimorfizma gena IL-28 / A.N. Kozina, D.D. Abramov, E.A. Klimova [i dr.] // Lechaschii vrach. — 2011. — № 10. — S.39—43.

 

PDF downloadFeatures hypertrophy of left ventricular and varia-tions remodeling myocardium in patients with hypertensive nephropathy

Olga N. Sigitova, Elvira I. Saubanova

Abstract. The incidence, characteristics of the formation of left ventricular hypertrophy (LVH) and myocardial remodeling in 120 patients 32–80 years with essential hypertension (EH) II–III stage (duration 11,3 years) in 2 groups: without hypertensive nephropathy (Hn) and with Hn, and in 2 subgroups of patients: with proteinuric (PU) and a non-empty goal. Patients with Hn changing the geometry and concentric hypertrophy of myocardial infarction occurred more frequently than those without Hn (respectively 25 and 20%). The thickness of the interventricular septum (IVST) and the rear wall of the left ventricle, and (TZSlv) in patients with predominated Hn: (1,17±0,03) cm and (1,08±0,018) cm, (1,2±0,02) cm and (1,05±0,017) cm respectively, p <0,05. Left ventricular mass (LVM) and the index (LVMI) with Hn were higher than those without Hn, respectively: (208,4±7,4) g and (231,3±8,3) g, (128,3±6,5) g/m2 and (118,62±9,47) g/m2 (p <0,05). Concentric hypertrophy with PU variant Hn occurred more frequently in comparison with non-empty (72 and 8%). The results showed a higher frequency, the degree of left ventricular hypertrophy and remodeling in the presence of Hn than without it, and at PU version of Hn – compared to non-PU.

Key words: hypertrophy of the left ventricle, remodeling, hypertensive nephropathy, hypertensive disease.

 

References

  1. Arutyunov, G.P.  Eksperimental’nye modeli porazheniya tubulointersticial’noi tkani pochek pri arterial’noi gipertenzii / G.P. Arutyunov, A.V. Sokolova, L.G. Oganezova / Klinicheskaya nefrologiya. – 2011. – № 2. – S.75–78.
  2. Gogin, E.E. Arterial’naya gipertoniya i pochki / E.E. Gogin // Terapevticheskii arhiv. – 1997. – № 6. – S.65–68.
  3. Kobalava, Zh.D. Novoe v lechenii arterial’noi gipertonii / Zh.D. Kobalava // Praktikuyuschii vrach. – 2001. – № 2. – S.1–10.
  4. Kobalava, Zh.D. Znachenie razlichnyh metodov ocenki funkcional’nogo sostoyaniya pochek dlya stratifikacii serdechno-sosudistogo riska / Zh.D. Kobalava, S.V. Villeval’de, V.S. Moiseev // Kardiologiya. – 2007. – № 12. – S.74–79.
  5. Kutyrina, I.M. Lechenie pochechnoi gipertonii / I.M. Kutyrina // Russkii medicinskii zhurnal. – 2001. – T. 8, № 3. – S.124–127.
  6. Moiseev, V.S. Kardiorenal’nyi sindrom (pochechnyi faktor i povyshenie riska serdechno-sosudistyh zabolevanii) / V.S. Moiseev, Zh.D. Kobalava // Klinicheskaya farmakologicheskaya terapiya. – 2002. – № 11 (3). – S.16–18.
  7. Muhin, N.A. Al’buminuriya – marker porazheniya pochek i riska serdechno-sosudistyh oslozhnenii / N.A. Muhin, G.P. Arutyunov. V.V. Fomin // Klinicheskaya nefrologiya. – 2009. – № 1. – S.5–10.
  8. Muhin, N.A. Kardiorenal’nye vzaimodeistviya: klinicheskoe znachenie i rol’ v patogeneze zabolevanii serdechno-sosudistoi sistemy i pochek / N.A. Muhin, V.S. Moiseev, Zh.D. Kobalava [i dr.] // Terapevticheskii arhiv. – 2004. – № 6. – S.39–46.
  9. Muhin, A.N. Porazhenie pochek pri gipertonicheskoi bolezni (gipertonicheskaya nefropatiya) / A.N. Muhin, V.V. Fomin // Rukovodstvo po arterial’noi gipertonii / pod red. E.I. Chazova, I.E. Chazovoi. – M.: Media Medika, 2005. – S.265–288.
  10. Muhin, N.A. Mikroal’buminuriya – integral’nyi marker kardiorenal’nyh vzaimootnoshenii pri arterial’noi gipertonii / N.A. Muhin [i dr.] // Consilium medicum. – 2007. – T. 9, № 5. – S.13–19.
  11. Muhin, N.A. Snizhenie skorosti klubochkovoi fil’tracii – obschepopulyacionnyi marker neblagopriyatnogo prognoza / N.A. Muhin // Terapevticheskii arhiv. – 2007. – № 6. – S.5–10.
  12. Oganov, R.G. Epidemiologiya arterial’noi gipertonii v Rossii. Vozmozhnosti profilaktiki / R.G. Oganov // Terapevticheskii arhiv. – 1997. – № 9. – S.3–6.
  13. Sigitova, O.N. Profilaktika, lechenie, nefroprotekciya pri hronicheskoi bolezni pochek / O.N. Sigitova // Remedium. Povolzh’e. – 2013. – № 1. –S.28–32.
  14. Shilov, E.M. Sovremennye principy diagnostiki i lecheniya hronicheskoi bolezni pochek: metodicheskoe rukovodstvo dlya vrachei / E.M. Shilov, M.Yu. Shvecov, I.N. Bobkov. – 2-e izd., ispr. i dop. – Saratov, 2011. – S.15–26.
  15. K/DOQI: Klinicheskie prakticheskie rekomendacii po hronicheskomu zabolevaniyu pochek. Ocenka, klassifikaciya i stratifikaciya. – URL: http://www.dialysis.ru/standard/doqi-ckd/g7.htm
  16. Ohkubo, T. Reference values for 24-hour ambulatory blood pressure monitoring based on a prognostic criterion The Ohasama Study / T. Ohkubo, Y. Imai, I. Tsuji [et al.] // Hypertens. – 1998. – Vol. 32. – P.255–259.

 

ORGANIZATION OF HEALTHCARE

PDF downloadCalculation of indirect costs of pneumonia in the Samara region

Olga D. Sivakova

Abstract. Aim. Calculation of indirect medical costs for pneumonia in the Samara region. Material and methods. Collecting and the analysis of data of federal state and branch statistical supervision for 2010 which formed a basis for the description of the medico-social characteristic of population of patients with pneumonia (the general, primary, hospitalized incidence, a lethality) in the Samara region. Results. Indirect medical costs consist of charges on social payments to patients (temporary disability benefit and disability pensions) and the half-received contribution to gross domestic product as a result of an absenteeism of workers for work. Costs of payment of sheets of temporary disability by reason of pneumonia in the Samara region made 32,9 million rubles, in the Volga federal district – 303,9 million rubles, in the Russian Federation – 1,5 billion rubles for 2010. Losses of a regional gross product by reason of temporary disability because of pneumonia in the Samara region for 2010 made 7,6 million rubles, in Volga federal district – 66,5 million rubles, in the Russian Federation – 464,5 million rubles. The fact of registration of disability the people who have had pneumonia, no therefore the disability pension with this disease isn't charged by the patient. Conclusion. Indirect medical costs of the state of treatment of pneumonia in the Samara region for 2010 make 40,5 million rubles that is 2,1% from costs of the state of all across Russia.

Key words: pharmacoeconomic, community-acquired pneumonia, indirect medical costs.

 

References

  1. Zaicev, A.A. Farmakoekonomicheskii analiz rezhimov antibakterial'noi terapii vnebol'nichnoi pnevmonii v stacionare / A.A. Zaicev [i dr.] // Prakticheskaya farmakoekonomika. Bronhopul'monologiya (nauchnyi sbornik). – M.: Farm Media, 2012. – S. 49–58.
  2. Kulikov, A.Yu. Metodologicheskii apparat farmakoekonomicheskih issledovanii / A.Yu. Kulikov // Prakticheskaya farmakoekonomika. Bronhopul'monologiya (nauchnyi sbornik). – M.: Farm Media, 2012. – S. 7–15.
  3. Os'kina, E.A. Metodicheskie i prakticheskie aspekty ocenki pryamyh medicinskih zatrat na bol'nyh pnevmoniei v otdel'no vzyatom regione / E.A. Os'kina, A.V. Zhestkov [i dr.] // Medicinskie tehnologii. Ocenka i vybor. – 2012. – № 3. – S. 16–24.
  4. Prakticheskaya farmakoekonomika. Bronhopul'monologiya (nauchnyi sbornik) / pod red. R.I. Yagudinoi. – M.: Farm Media, 2012. – 70 s.
  5. Baltolome, M. A population-based study of the costs of care for community-acquired pneumonia / M. Baltolome, J. Almirall, J. Morera [et al.] // Eur. Respir. J. – 2004. – Vol. 23. – P. 610–616.
  6. File, T.M.Jr. Burden of community-acquired pneumonia in North American adults / T.M.Jr. File, T.J. Marrie // Postgrad Med. – 2010. – Vol. 122. – P. 130–141.
  7. Pneumonia. Europian lung white book. – 2nd ed. – Sheffi eld, UK: Europian Respiratory Society; Europian Lung Foundation, 2003. – P. 55–65.
  8. Guest, J.F. Community-acquired pneumonia: the annual cost to the National Health Service in the UK / J.F. Guest, A. Morris // Eur. Respir. J. – 1997. – Vol. 10. – P. 1530–1534.
  9. Guest, J.F. Community-acquired pneumonia: the annual cost to the National Health Service in the UK / J.F. Guest, A. Morris // Eur. Respir. J. – 1997. – Vol. 10. – P. 704–708.
  10. Scott, G. Economic cost of community-acquired pneumonia in New Zealand adults / G. Scott, H. Scott, M. Turlay [et al.] // N. Z. Med. J. – 2004. – P. 117–119.

 

PDF downloadEstimation of quality of cardiological aid in public health services modernization

Eugenia А. Atsel

Abstract. In article various concepts, methodology and models of maintenance of quality of the medical aid rendered in establishments of system of public health services are discussed. Necessity of creation of conceptual model of management of quality of medical aid by the cardiological patients at regional level is underlined.

Key words: public health services, medical aid, quality of medical aid, medical aid quality management, cardiological patients.

 

References

  1. INТERNATIONAL STANDARD ISO 9000. Quality management systems – Fundamentals and vocabulary. – 2005. – Р. 4–40.
  2. Bedoreva, Yu.I. Rol’ principov vseobschego menedzhmenta kachestva v upravlenii federal’nym uchrezhdeniem zdravoohraneniya / Yu.I. Bedoreva, N.G. Fomichev, M.A. Sadovoi, V.YU. Samarina // Hirurgiya pozvonochnika. – 2006. – № 4. – S. 75–83.
  3. Donabedian, A. Twenty years of Research on the Quality of Medical care / A. Donabedian // Evaluation and the Health professions. –1985. – № 3. – P. 243–265.
  4. Donabedian, A. Models of quality assurance / A. Donabedian, S. Leonard, W. Osenfe // Memorial Lecture, School of Public Health University of North Carolina in Chapel HiB. –1993. – Febr. 26.
  5. Vuory, H.V. Quality assurance of health services / H.V. Vuory // Copenhagen, WHO Regional Office for Europe. Public Health in Europe. –1982. – № 16. – Р. 3–8.
  6. Palmer, R.H. Confronting Special Implementation Issue: The Epidemiology of Quality Problem in Medicare: New Directions in Quality Assurance / R.H. Palmer; еds. M.S. Donalson, S. Harris-Welling, K.N. Johr. – Washington, ОС: National Academy Press, 1991. –P. 96–104.
  7. Peterson, M.C. A systematic review of outcomes and quality measures in adult patients cared for by hospitalists vs nonhospitalists / M.C. Peterson // Mayo Clin. Proc. – 2009. –Vol. 84, № 3. – P. 248–254.
  8. Shou, Ch. Osnovy dlya razrabotki nacional’nyh strategii po usovershenstvovaniyu kachestva v sistemah zdravoohraneniya / Ch. Shou, A. Kalo. – VOZ, 1999. – 87 s.
  9. Komarov, Yu.M. Konceptual’nye podhody k upravleniyu kachestvom medicinskoi pomoschi / Yu.M. Komarov, A.V. Korotkova, G.I. Galanova // Upravlenie kachestvom medicinskoi pomoschi v Rossiiskoi Federacii: materialy ezhegodnoi 4-i Ros. nauch.-prakt. konf. NPO «Medsocekonominform». – M., 1997. –S. 28–55.
  10. Lukashev, A.M. Kompleksnyi podhod k upravleniyu kachestvom medicinskoi pomoschi / A.M. Lukashev // Klinicheskaya gerontologiya. – 2009. – T. 15, № 10/11. – S. 71–76.
  11. Uiba, V.V. Obscheteoreticheskie osnovy upravleniya kachestvom medicinskoi pomoschi / V.V. Uiba // Problemy upravleniya zdravoohraneniem. – 2005. – № 4. – S. 22–29.
  12. Kucherenko, V.Z. Organizaciya i ocenka kachestva lechebno-profilakticheskoi pomoschi naseleniyu: rek. UMO po med. i farmac. obrazovaniyu vuzov Rossii v kachestve ucheb. posobiya dlya studentov med. vuzov / V.Z. Kucherenko. – M.: GEOTAR-Media, 2008. – 560 s.
  13. Korotkova, A.V. Kachestvo i kontrol’ / A.V. Korotkova, E.I. Skachkova // Vestnik Roszdravnadzora. – 2010. – № 5. – S. 10–15.
  14. Timofeev, I.V. Organizacionno-upravlencheskie i pravovye aspekty sovershenstvovaniya medicinskogo obsluzhivaniya v sovremennyh usloviyah / I.V. Timofeev, V.F. Chavpecov, O.V. Gricak // Evraziiskaya integraciya: ekonomika, pravo, politika. – 2009. – № 6. – S. 77–79.
  15. Korotkova, A.V. Metodologicheskie podhody k ocenke rezul’tatov deyatel’nosti sistemy zdravoohraneniya v celom i postavschikov uslug / A.V. Korotkova, I.M. Son, C.A. Leonov // Social’nye aspekty zdorov’ya naseleniya. – 2008. – T. 7, № 3. – S. 4.
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  18. Vorob’ev, P.A. Kachestvo medicinskoi pomoschi: problemy ocenki, kontrolya i upravleniya / P.A. Vorob’ev // Problemy standartizacii v zdravoohranenii. – 2007. – № 10. – S. 6–14.
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  20. Mihailova, N.V. Metodologiya obespecheniya i upravleniya kachestvom medicinskoi pomoschi v sootvetstvii s mezhdunarodnymi standartami ISO SERII 9000 / N.V. Mihailova // Vestnik Roszdravnadzora. – 2010. – № 3. – S. 19–27.
  21. Gurov, P.A. Aktual’nye voprosy standartizacii, upravleniya kachestvom v vosstanovitel’noi medicine / P.A. Gurov, A.E. Verikovskii, E.D. Nesterov // Kvalifikaciya i kachestvo. – 2003. – № 1. – S. 19–21.
  22. Levinson, U.A. Lechenie kachestvom: standart ISO 9001 protiv vrachebnyh oshibok / U.A. Levinson // ISO 9000-14000. – 2006. – № 5. – S. 11–13.
  23. Lomakin, A.G. Sovremennye tendencii upravleniya kachestvom medicinskoi pomoschi v mnogoprofil’nom LPU / A.G. Lomakin // Vestnik Nacional’nogo mediko-hirurgicheskogo centra im. N.I. Pirogova. – 2009. – T. 4, № 2. – S. 102–109.
  24. Boll, S.V. Problemy formirovaniya edinoi sistemy standartizacii v zdravoohranenii / S.V. Boll, Yu.G. Golinskii // Glavvrach. – 2006. – № 9. – S. 41–45.

 

EXCHANGE OF EXPERIENCE

PDF downloadWays of prediction disability in police officers

Anna A. Kulakova, Sergey V. Smolyaninov

Abstract. The aim of our study was investigation of relationship between the various risk factors and morbidity and the structure of diseases of police officers. Therefore, we found predictors of t the risk of permanent disability as a consequence of the action set of risk factors. Material and Methods. The data of medical records of hospital patients, yearly accounts, reports of computer database «CLINIC» and surveys of police officers. Results and discussion. We detect the battery of markers of medical and social data, affecting on disability and level of health of police officers. The result of our analysis was a construction of mathematical model to implement forecast changes in the health status and disability of police officers. Conclusion. Constructed models can predict the implementation of disability of police officers and changes in their health status in cases of changing socio-hygienic characteristics in order to choose the rational management decisions.

Key words: staff of police officers, morbidity, risk factors, disability.

 

References

  1. Aktual’nye voprosy upravleniya zdravoohraneniem: monografiya / pod red. D.V. Pivenya. – M.: Izdat. dom «Menedzher zdravoohraneniya», 2008. – 139 s.
  2. Vishnyakov, N.I. Mnenie pacientov kak vazhnyi kriterii kachestva medicinskoi pomoschi / N.I. Vishnyakov, N.G. Petrova, S.A. Balohina [i dr.] // Problemy upravleniya zdravoohraneniem. – 2009. – № 2 (45). – S. 43–45.
  3. Grishin, V.V. Reforma nacional’noi sistemy zdravoohraneniya / V.V. Grishin // Zdravoohranenie. – 2008. – № 4. – S. 139–144.
  4. Kalininskaya, A.A. Upravlenie zdravoohraneniem, puti reorganizacii otrasli. Aktual’nye problemy profilakticheskoi i lechebnoi mediciny / A.A. Kalininskaya, S.I. Kuznecov, M.V. Vorob’ev // Materialy mezhinstitutskoi nauch. konf. s mezhdunarodnym uchastiem, posvyasch. 65-letiyu okonchaniya Vtoroi mirovoi voiny; 3 sentyabrya 2010 g. – M.: GOU VPO MGMSU Roszdrava, 2010. – S. 8–10.
  5. Kompleksnye issledovaniya po razrabotke sistemy ohrany zdorov’ya voennosluzhaschih v usloviyah reformirovaniya Vooruzhennyh sil Rossiiskoi Federacii: rabochie materialy k otchetu po teme KNIR / BMA im. S.M. Kirova; ruk. V.Yu. Tegza; ispoln. E.V. Ivchenko. – SPb., 2007. – 140 s.
  6. Markova, S.M. Klinicheskoe administrirovanie v deyatel’nosti po uluchsheniyu kachestva medicinskoi pomoschi / S.M. Markova // Voprosy ekspertizy i kachestva medicinskoi pomoschi. – 2009. – № 2. – S. 32–35.
  7. Togoev, A.M. Reforma zdravoohraneniya Rossiiskoi Federacii i innovacionnaya medicina / A.M. Togoev, L.A. Bhardvadzh. – M., 2005. – 404 s.
  8. Abodollahi, М. Kathrine Understanding police stress research / M. Abodollahi // J. Forens. Psychol. Prakt. – 2002. – Vol. 2, № 2. – P. 124.
  9. Cordeiro, R. Stressful life events and occupational accidents / R. Cordeiro, A. Dias // Scand. J. Work, Environ and Health. – 2005. – Vol. 31, № 5. – P. 336–342.
  10. The management of health, safety and welfare issues for NHS by Department of Health. – London, 2003. – P. 13 15, 54–72, 111–125.

 

PDF downloadExperience of coccygodynia treatment

Ilsur M. Fatkhutdinov

Abstract. Aim. To develop the optimum scheme of coccygodynia diagnosis and treatment to improves the quality of life of patients. Methods. A 18 patients with pain in the coccyx were observed [17 (94,4%) females and 1 (5,6%) men aged 25 to 63 years] in Central City Clinical Hospital № 18 in Kazan from 2007 to 2012. Results. In two cases were not positive dynamics on the background of the treatment. Before the completion of conservative therapy, patients were additionally reexamined and open disk herniation in the lumbar-sacral spine were revealed. Appropriate neurological treatment in both observations showed improvement. The remaining patients reported a positive trend after the first course of the treatment of blockages. On the remote periods (from 1 to 5 years), there were no signs of the disease. Conclusions. Thus, complex therapy coccygodynia that includes para-artikula blockades with drugs and TraumelS Alflutop, acupuncture, receiving chondroprotectors allows stopping inflammation and pain in the sacrococcygeal joint, thereby improving the quality of life for patients.

Key words: coccygodynia, pain, complex treatment.

 

References

  1. Krasnov, A.F. Spravochnik po travmatologii / A.F. Krasnov, V.M. Arshin, M.D. Ceitlin. – M.: Medicina, 1984. – 400 s.
  2. Mal’cev, V.N. Medicinskaya reabilitaciya bol’nyh s neopuhlevymi zabolevaniyami pryamoi kishki, anal’nogo kanala i myagkih tkanei promezhnosti / V.N. Mal’cev. – Har’kov: Tornado, 2004. – 202 s.
  3. Rivkin, V.L. Rukovodstvo po koloproktologii / V.L. Rivkin, S.N. Fain, A.S. Bronshtein. – M.: Medpraktika-M, 2004. –488 s.
  4. Fedorov, V.D. Proktologiya / V.D. Fedorov, Yu.V. Dul’cev. – M.: Medicina, 1984. – 384 s.

 

PDF downloadECG findings in apical left ventricular hypertrophy

Lilia KH. Safargalieva, Naila A. Mukhametzyanova, Nail B. Amirov, Lilia F. Baybulatova, Galina V. Tukhvatullina

Abstract. The article presents the characteristics of the development of cardiac hypertrophy in arterial hypertension. It is known that the presence of LVH, regardless of the level of blood pressure, is a bad prognostic sign, but the main risk factor for cardiovascular disease and mortality from cardiovascular diseases is arterial hypertension. In the theoretical part of current article we describe the changes that develop in hypertension in the myocardium. The classification and the types of myocardial hypertrophy are presented. A distinguishing feature of the apical form of hypertrophy of the left ventricle accompanied by ECG changes similar to a heart attack is allocated. In the present case report we described infarction-like ECG changes in a patient with apical left ventricular hypertrophy with arterial hypertension. Patient laboratory and instrumental studies, the findings and results are reviewed. Thoroughly made examination of the patient allowed us to exclude acute myocardial infarction and coronary heart disease.

Key words: arterial hypertension, left ventricular apical hypertrophy, myocardial mass index.

 

References

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  2. Belenkov, Yu.N. Serdechno-sosudistyi kontinuum / Yu.N. Belenkov, V.Yu. Mareev // Serdechnaya nedostatochnost’. – 2002. – № 3 (1). – S. 7–11.
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  4. Rybakova, M.K. Prakticheskoe rukovodstvo po ul’trazvukovoi diagnostike / M.K. Rybakova, M.N. Alehin, V.V. Mit’kov. – M.: VIDAR, 2008.
  5. Novikov, V.I. Ocenka diastolicheskoi funkcii serdca i ee rol’ v razvitii serdechnoi nedostatochnosti / V.I. Novikov, T.N. Novikova, S.R. Kuz’mina-Kruteckaya, V.E. Ironosov // Kardiologiya. – 2001. – № 2. – S. 78–85.
  6. Oslopov, V.N. Znachenie membrannyh narushenii v razvitii gipertonicheskoi bolezni: avtoref. dis. ... d-ra med. nauk / V.N. Oslopov. – Kazan’, 1995. – S. 48.
  7. Parfenova, E.V. Soderzhanie v krovi gormonov, neiromediatorov i gipertrofiya levogo zheludochka u bol’nyh gipertonicheskoi bolezn’yu / E.V. Parfenova, E.G. D’yakonova, V.P. Masenko [i dr.] // Kardiologiya. – 1995. – № 7(35). – S. 18–23.
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  10. Chazova, I.E. Puti obrazovaniya angiotenzina-II i vozmozhnosti lecheniya bol’nyh s arterial’noi gipertenziei / I.E. Chazova // Arterial’naya gipertenziya. – 2002. – № 5/6. – S. 3–5.
  11. Canau, A. Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension / A. Canau, R.B. Devereux, M.J. Roman [et al.] // J. Am. Coll. Cardiology. – 1992. – Vol. 19. – P. 1550–1558.
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  15. Lang, R.M., Bierig M., Devereux R.B. [et al.] // Eur. J. Echocardiography. – 2006. – Vol. 7. – P. 79–108.
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PDF downloadAcute myocarditis in practis of doctor (a clinical case)

Guzel A. Mukhametshina, Nail B. Amirov, Elvira B. Frolova, Fania F. Agliullina, Naila A. Mukhametzyanova, Anastasia A. Morozova

Abstract. The article describes the various international standards recommended methods of diagnosis of myocarditis, as instrumental, using modern techniques and laboratory. Particular attention is paid to endomyocardial biopsy in combination with biochemical and immunohistochemical methods of research. The lack of specific symptoms in the clinical picture of myocarditis, the difficulties in identifying causative agent or pathogen often lead to errors in diagnosis, which degrades both during and prognosis of the disease. We submitted a clinical case of a patient with an acute course of myocarditis is of particular interest because in the guise of a trivial viral infection lurks a heavy defeat infarction. Particular caution physician to the nature of the flow of infection and assessment of the complete set of symptoms and the diagnostic criteria allow an accurate diagnosis.

Key words: myocarditis, endomyocardial biopsy, antiviral therapy.

 

References

  1. Kovalenko, V.N. – 2004; Dennert, R. [et al.]. – 2008.
  2. Paleev, N.R., Gurevich M.A. // Klinicheskaya medicina. – 1998. – № 9. – S. 4–7.
  3. Roitberg, G.E. Vnutrennie bolezni. Serdechno-sosudistaya sistema / G.E. Roitberg; pod red. A.V. Strutynskogo. – M., 2003. – S. 739–751, 767–784.
  4. Chazov, E.I. Rukovodstvo po kardiologii / E.I. Chazov. – M., 1992. – T. 2.
  5. Osobennosti klinicheskogo techeniya, diagnostiki i lecheniya otdel’nyh form miokardita // Kardioportal:cardioportal.ru
  6. Kovalenko, V.N. Rukovodstvo po kardiologii / V.N. Kovalenko. – Kiev, 2008.
  7. Sorokin, E.V. Miokardity v klinicheskoi praktike: sovremennye predstavleniya o staroi bolezni / E.V. Sorokin, Yu.A. Karpov // Russkii medicinskii zhurnal. –2001. – T. 9, № 10.
  8. Paleev, N.R. Miokardity / N.R. Paleev [i dr.]. – M., 1982.
  9. Boicov, S.A., Deryugin M.V. // Consilium medicum. – 2002. – № 4. – S. 3.
  10. Ruzhencova, T.A. Principy medikamentoznoi terapii miokarditov u detei / T.A. Ruzhencova, A.V. Gorelov, T.V. Smirnova.
  11. Deryugin, M.V. Hronicheskie miokardity / M.V. Deryugin, S.A. Boicov. – SPb.: ELBI-SPb., 2005. – 288 s.
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PDF downloadVideo-digital system on the basis of «Expert-Lab» for automatic registration of the results of the immune blotting for the diagnosis of syphilis

Seyfaddin G. Mardanly, Aleksey E. Tugolukov, Tatiana A. Starovoytova, Alexandra S. Avdonina, Olga I. Kirdanovskaya, Jury Ju. Vengerov

Abstract. Developed the system of automatic registration and interpretation of results of research by method of immune blotting for the diagnosis of syphilis on the basis of domestic video- digital hardware-software complex of the «Expert-lab» and the special software of Line-Blot Syphilis (Ecolab)», adapted to the application of relevant sets of reagents CJSC «Ecolab», and holder for accommodation strips of immunosorbent assay in the optical block of AIC. The system successfully tested in conducting of Immune blotting 88 samples of human blood serum and 14 samples of cerebrospinal fluid of humans. Shows the possibility of the effective use of all the advantages video- digital registration (save the original document, opportunity retrospective control and elimination of accounting of results) when conducting confirmatory studies of syphilis and other infections (such as HCV and HIV-infection) by immune blotting method in the format Line-blot.

Key words: Immune blotting, syphilis, Line-blot, video registration of the results.

 

References

  1. Markina, M.V. Immunoblot v diagnostike infekcionnyh zabolevanii. Novye vozmozhnosti: prakt. rukovodstvo po interpretacii poluchennyh rezul’tatov / M.V. Markina, V.V. Romanov. – URL: http://www.labdiagnostic.ru/docs/specialists/immunoblot_infect.shtml
  2. Katalog firmy «Helikon». Ctanciya vestern-blottinga BenchPro 4100. – URL: http://www.helicon.ru/catalog/detail.php?IBLOCK_ID=4&SECTION_ID=321&ELEMENT_ID=2201
  3. Starovoitova, T.A. Videocifrovoi analiz dlya laboratornoi diagnostiki: kompleks «Ekspert-Lab» na osnove skanera dlya dokumentirovaniya, ob’ektivizacii i registracii rezul’tatov lateks-agglyutinacionnyh, gemagglyutinacionnyh testov, izoserologicheskih i immunofermentnyh issledovanii / T.A. Starovoitova, V.V. Zaiko, N.A. Steriopolo [i dr.] // Laboratoriya. – 2006. – № 1. – S. 19–22.
  4. Steriopolo, N.A. Primenenie skanera dlya registracii rezul’tatov immunofermentnogo analiza v standartnyh mikroplanshetah / N.A. Steriopolo, V.V. Zaiko, O.S. Kalacheva [i dr.] // Klinicheskaya laboratornaya diagnostika. – 2006. – № 11. – S. 44–46.
  5. Starovoitova, T.A. Videocifrovoi analiz dlya laboratornoi diagnostiki: kompleks «Ekspert-Lab» na osnove skanera dlya dokumentirovaniya i registracii rezul’tatov lateks-agglyutinacionnyh testov i immunofermentnyh issledovanii / T.A. Starovoitova, N.A. Steriopolo, V.V. Zaiko [i dr.] // Materialy dokladov seminarov i konferencii v ramkah vystavki «AnalyticaExpo-2006». – M., 2006. – S. 42–43.

 

PDF downloadTo a question of pulmonary artery thromboembolism

Guzel A. Mukhametshina, Nail B. Amirov, Elvira B. Frolova, Olga Ju. Mikhoparova, Oleg Ju. Dmitriev, Marina S. Spiridonova

Abstract. The relevance of the problem is that pulmonary embolism is the third largest cause of death (dying each year 0,1% of the population) after myocardial infarction and stroke. Pulmonary embolism – complication of various diseases and conditions that give rise to deep thrombosis in the venous system, the right chambers of the heart or causing local thrombosis in the pulmonary artery. This article presents a literary reference on the algorithm of diagnosis and treatment of pulmonary embolism, as in life only in 50–70% of cases exhibit an accurate diagnosis. The complexity of diagnosis is that there are no clear criteria in specific clinical, laboratory diagnosis and non-invasive instrumental methods of investigation. The gold standard for the diagnosis of pulmonary embolism is angiography, which is not always available. The demonstration of a clinical case is of great interest to the clinician in terms of the relevance of the disease.

Key words: pulmonary embolism, deep vein thrombosis.

 

References

  1. Parhomenko, A.N. Tromboemboliya legochnoi arterii: algoritmy diagnostiki i lecheniya / A.N. Parhomenko, O.I. Irkin, Ya.M. Lutai; Nacional’nyi nauch.-issled. centr “Institut kardiologii im. akad. N.D. Strazhesko”, g. Kiev, simpozium № 7. – URL: (http://www.mif-ua.com/education/symposium/tromboemboliya-legochnoj-arterii-algoritmy-diagnostiki-i-lecheniya)
  2. Shilov, A.M. Tromboemboliya vetvei legochnoi arterii: patofiziologiya, klinika, diagnostika, lechenie / A.M. Shilov, M.V. Mel’nik, I.D. Sanodze, I.L. Sirotina; MMA im. I.M. Sechenova. – URL: (http://www.rmj.ru/articles_623.htm)
  3. Yakovlev, V.B. Venoznye tromboembolicheskie oslozhneniya: diagnostika, lechenie, profilaktika / V.B. Yakovlev, M.V. YAkovleva // Rossiiskie medicinskie vesti. – 2002. – № 2.
  4. Darryl ,Y. Pulmonary Disease / Y. Darryl; S.D. Frederic (ed.) 1st еd. – Current: Critical Care Diagnosis & Treatment –US – a lange medical book. – P.496.
  5. Torbicki, A. Guidelines on the diagnosis and management of acute pulmonary embolism. The Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC) / A. Torbicki, A. Perrier, S. Konstantinides [et al.] // European Heart Journal. – 2008. – Vol. 29 (18). – P.2276–2315.

 

REVIEW

PDF downloadPeculiarity of coronary lesions in patients with silent myocardial ischemia

Svetlana D. Mayanskaya, Dilara R. Tavkaeva

Abstract. This is overview of the literature on silent myocardial ischemia (SMI) in view of coronary lesions on coronary angiography data. There are conflicting reports about the severity of atherosclerotic lesions according to coronary angiography in patients with SMI. It is not clear whether the predominant in these patients a greater degree of stenosis of the coronary arteries or multivessel disease. It should be noted that there is inconsistency of available data on coronary artery lesion severity and the frequency of occurrence of SMI according to the current literature, which certainly requires further study.

Key words: silent myocardial ischemia, coronary angiography, coronary arteries, multivessel disease.

 

References

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  2. Anchipolovskaya, N.G. «Nemaya» ishemiya miokarda: sravnitel’naya ocenka metodov vyyavleniya, klinicheskoe i prognosticheskoe znachenie / N.G. Anchipolovskaya, B.Ya. Bart, S.E. Baschinskii // Kardiologiya. – 1994. – № 5. – С. 82–86.
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  5. Kuliev, O.A. Osobennosti klinicheskih proyavlenii ishemicheskoi bolezni serdca v podostroi stadii infarkta miokarda i postinfarktnogo kardioskleroza v zavisimosti ot sostoyaniya koronarnyh arterii / O.A. Kuliev, L.S. Zingerman, A.A. Spasskii // Kardiologiya. – 1991. – № 11. – S. 37–40.
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  41. Zellweger, M.J. Therapeutic strategies in patients with chronic stable coronary artery disease / M.J. Zellweger, M.E. Pfisterer // Cardiovasc. Ther. – 2011. – Vol. 29, № 6. –P. 23–30.

 

PDF downloadPositive inotropic agents for treatment of acute heart failure

Svetlana D. Mayanskaya

Abstract. This article is devoted of review, thatanalyse well-known modern positive inotropic agents, using for acute heart failure de novo and acute decompensated of chronic heart failure. In this review is described modern classifications and characteristic of inotropic agents. Itwasnoted, the lastyears the spectrum of positive inotropic agents with contributory action on hemodynamic in heart failure, particularly in transitory treatment is extended.

Key words: acute heart failure,acute decompensated of chronic heartfailure, positive inotropic agents.

 

References

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  2. Gurevich, M.A. Neglikozidnye inotropnye sredstva i novye neirogumoral’nye antagonisty v lechenii serdechnoi nedostatochnosti / M.A. Gurevich // Rossiiskii kardiologicheskii zhurnal. – 2003. – № 3. – S.87–92.
  3. Mareev, V.Yu. Lechenie serdechnoi nedostatochnosti: inotropnaya stimulyaciya ili razgruzka serdca? / V.Yu. Mareev // Kardiologiya. – 1993. – № 12. – S.6–14.
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