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CITY CHILDREN'S HOSPITAL № 1: HISTORICAL SKETCH OF DEVELOPMENT OF THE CITY NURSERY OF HOSPITAL № 1 OF KAZAN
MARINA V. POTAPOVA, ELENA A. KUZMINA
Abstract. The short sketch of history of development of city children’s hospital № 1 of Kazan is given in article. Posveshchen to the 30th lithium of stationary service «City Children’s Hospital № 1» of Kazan
Key words: city children’s hospital № 1 of Kazan, medicine history.
CHILDREN'S CITY HOSPITAL № 1 OF KAZAN AND THE DEPARTMENT OF PEDIATRICS AND NEONATOLOGY KSMA: A HISTORY OF SOLIDARITY
ASIA I. SAFINA, ILDOUS Y. LUTFULLIN
Abstract. The article provides a brief sketch of the history of the joint development of the department of pediatrics and neonatology Kazan State Medical Academy and the Children’s City Hospital № 1 of Kazan.
Key words: Department of Pediatrics and Neonatology Kazan State Medical Academy, Children’s City Hospital № 1 in Kazan, the history of medicine.
© Р.А. Файзуллина, В.В. Софронов, Т.Г. Маланичева, Н.В. Зиатдинова, 2013
УДК 614.21(09)(470.41-25):378.4
ИСТОРИЯ КАФЕДРЫ (КУРСА) ДЕТСКИХ БОЛЕЗНЕЙ ЛЕЧЕБНОГО ФАКУЛЬТЕТА КАЗАНСКОГО ГОСУДАРСТВЕННОГО МЕДИЦИНСКОГО УНИВЕРСИТЕТА И ЕЕ РОЛЬ В ОРГАНИЗАЦИИ ОТДЕЛЕНИЯ ПАТОЛОГИИ НОВОРОЖДЕННЫХ ГДБ № 1 Г. КАЗАНИ
РЕЗЕДА АХАТОВНА ФАЙЗУЛЛИНА, докт. мед. наук, доцент, зав. кафедрой пропедевтики детских болезней и факультетской педиатрии с курсом детских болезней лечебного факультета ГБОУ ВПО «Казанский государственный медицинский университет», Казань, Россия, e-mail: rector@kgmu.kcn.ru
ВАЛЕРИЙ ВИКТОРОВИЧ СОФРОНОВ, докт. мед. наук, профессор кафедры пропедевтики детских болезней и факультетской педиатрии с курсом детских болезней лечебного факультета ГБОУ ВПО «Казанский государственный медицинский университет», Казань, Россия, e-mail: rector@kgmu.kcn.ru
ТАТЬЯНА ГЕННАДЬЕВНА МАЛАНИЧЕВА, докт. мед. наук, профессор кафедры пропедевтики детских болезней и факультетской педиатрии с курсом детских болезней лечебного факультета ГБОУ ВПО «Казанский государственный медицинский университет», Казань, Россия, e-mail: rector@kgmu.kcn.ru
НЕЛЛИ ВАЛЕНТИНОВНА ЗИАТДИНОВА, канд. мед. наук, доцент кафедры пропедевтики детских болезней и факультетской педиатрии с курсом детских болезней лечебного факультета ГБОУ ВПО «Казанский государственный медицинский университет», Казань, Россия, e-mail: rector@kgmu.kcn.ru
Реферат. В статье приводится исторический очерк развития и становления кафедры пропедевтики детских болезней и факультетской педиатрии с курсом детских болезней лечебного факультета КГМУ МЗ РТ, а также ее роль в организации отделения патологии новорожденных и недоношенных детей городской детской больницы № 1 г. Казани.
Ключевые слова: кафедра пропедевтики детских болезней, история медицины, Казанский медицинский университет.
GENDER IDENTITY — A BASIS FOR EARLY SURGICAL CORRECTION OF CHILDREN WITH DISIRDER OF SEX DEVELOPMENT
NAIL R. AKRAMOV, ILSIYAR A. AKRAMOVA, AYDAR K. ZAKIROV, AIDA F. MINULLINA
Abstract. The article is devoted to the formation of gender identity in children with abnormal sex. Age-specifc gender identity was considered. There wasmodern understanding of cognitive, affective and evaluative, and behavioral components of the disorders was shown in the structure of sexual gender identity in childhood, depending on the formation of genital malformations of child. Detected psychological factors were the basis for recommendations to early surgical correction in children with disorder of sex development.
Key words: gender, gender identity, impaired formation of gender, surgical correction in children with disorder of sex development.
1. Adler, A. Psihicheskij germafroditizm i muzhskoj protest — central'naja problema nervnyh zabolevanij / A. Adler // Praktika i teorija individual'noj psihologii: lekcii po vvedeniju v psihoterapiju dlja vrachej, psihologov i uchitelej. — M.: Izd-vo Instituta psihoterapii,
2002. — S.22—30.
2. Andreeva, L.V. Problema formirovanija gendernyh predstavlenij u detej 4—5 let s narusheniem rechi / L.V. Andreeva, V.V. Lukovnikova // Psihologija, sociologija i pedagogika. — 2012. — № 4. — URL: http://psychology. snauka.ru/2012/04/476 (data obrashhenija: 25.08.2013).
3. Asmolov, A.G. Psihologija lichnosti: uchebnik / A.G.Asmo-lov. — M.: Izd-vo MGU, 1990. — 367 s.
4. Bern, Sh. Gendernaja psihologija / Sh. Bern. — SPb.: Prajm-EVROZNAK, 2002. — 320 s.
5. Vasil'chenko, G.S. Obshhaja seksopatologija / G.S. Vasil'chen-ko. — L.: Medicina, 1977. — 488 s.
6. Il'chenko, L.V. Razvitie psihologicheskogo pola rebenka-doshkol'nika (4—7 let): Avtoref. dis. … kand. psihol. nauk / L.V. Il'chenko. — Rostov na/D., 1996 — 24 s.
7. Isaev, D.N. Psihogigiena pola u detej: (rukovodstvo dlja vrachej) / D.N. Isaev, V.E. Kagan. — L.: Medicina, 1986. — 336 s.
8. Kagan, V.E. Kognitivnye i jemocional'nye aspekty gen-dernyh ustanovok u detej 3—7 let / V.E. Kagan // Voprosy psihologii. — 2000. — № 2. — S.65—69.
9. Klecina, I.S. Gendernaja socializacija: ucheb. posobie / I.S. Klecina. — SPb., 1998. — 92 s.
10. Kon, I.S. Psihologija polovyh razlichij / I.S. Kon // Psihologija individual'nyh razlichij: hrestomatija / pod red. Ju.B. Gippenrejter, V.Ja. Romanova. — M.: CheRo, 2000. — 776 s.
11. Kon, I.S. Vvedenie v seksologiju / I.S. Kon. — M.: Medicina, 1989. — 336 s.
12. Leont'ev, A.N. Psihicheskoe razvitie rebenka v doshkol'nom vozraste / A.N. Leont'eva // Voprosy psihologii rebenka doshkol'nogo vozrasta / pod red. A.N. Leont'eva, A.V. Zaporozhca. — M., 1948. — S.4—15.
13. Lichko, A.E. Podrostkovaja psihiatrija: rukovodstvo dlja vrachej / A.E. Lichko. — 2-e izd., dop. i pererab. — L.: Medicina, 1985. — 416 s.
14. Lopuhova, O.G. Psihologicheskij pol lichnosti v kontekste gendernyh issledovanij / O.G. Lopuhova // Vestnik TGGPU. — 2001. — № 4 (26). — S.384—390.
15. Malkina-Pyh, I.G. Gendernaja terapija: spravochnik prakticheskogo psihologa /I.G. Malkina-Pyh. — M.: Jeksmo,
2003. — 522 s.
16. Ovcharova, R.V. Prakticheskaja psihologija obrazovanija: ucheb. posobie / R.V. Ovcharova. — M.: Izdat. centr «Akademija», 2003. — 448 s.
17. Sokolova, E.T. Obosnovaniju kliniko-psihologicheskogo izuchenija rasstrojstva gendernoj identichnosti / E.T. Sokolova, N.S. Burlakova, L.K. Fotula // Voprosy psihologii. — 2001. — № 6. — S.3—16.
18. Trufanova, O.K. Psihologicheskie i psihofiziologicheskie osobennosti inversnoj polovoj identichnosti pri transseksualizme: avtoref. dis. … kand. med. nauk / O.K. Trufanova. — Rostov na/D. — 1996. — 22 s.
19. Jerikson, Je. Detstvo i obshhestvo / Je. Jerikson. — SPb.: Lenati, 1996. — 592 s.
EFFICIENCY OF ANTIEPILEPTIC DRUGS OF NEW GENERATION IN THERAPY OF CRYPTOGENIC AND SYMPTOMATIC FOCAL FORMS OF EPILEPSY IN CHILDREN
SVETLANA N. SIVKOVA, FANIYA M. ZAYKOVA
Abstract. Purpose. Comparison of the clinical effciency of antiepileptic drugs of new generation — topiramate and lamotrigine — in treatment of symptomatic and cryptogenic focal forms of epilepsy in children. Material and methods. 2 groups of patients were included in research, aged from 2 to 17 years old, on 31 person in each group with symptomatic and cryptogenic focal forms of epilepsy. 1 group of patients were treated by topiramate in dozes from 56 up to 500 mg/day, from 2,8 mg/kg/day up to 17 mg/kg/day (on the average 6,6 mg/kg/day). Patients of the second group received therapy by lamotrigine in dozes from 25 mg/day up to 250 mg/day, from 0,5 mg/kg/day up to 6 mg/kg/day (on the average 3,6 mg/ kg/day). Treatment was in monotherapy and in combinations with others antiepileptic grugs. Results. Seizures freedom was achieved in 26% of patients in each groups. Reduction of seizures freqency more than 50% was observed in 61 % cases in topiramate group and in 45% of cases in lamotrigine group. Aggravation of myoclonic seizures was registered in 1 (3%) patient, used topiramate and in 2 (6%) patients used lamotrigine. Conclusion. Topiramate and lamotrigine have shown high clinical effciency in treatment symptomatic and cryptogenic focal forms of epilepsy in children.
Key words: focal epilepsy, treatment, children, topiramate, lamotrigine.
References
1. Boldyreva, S.R. Sravnitel'naja ocenka sovremennyh antijepilepticheskih preparatov pri visochnoj medial'noj jepilepsii u detej / S.R. Boldyreva // Klinicheskaja jepileptologija. — 2007. — № 1. — S.23—27.
2. Voronkova, K.V. Jeffektivnost' topiramata (topamaksa) u bol'nyh jepilepsiej raznogo vozrasta / K.V. Voronko-va, O.A. Pylaeva, A.S. Petruhin // Zhurnal nevrologii i psihiatrii im. S.S. Korsakova. — 2006. — T. 106, № 6. — S.34—37.
3. Geht, A.B. Opyt primenenija topamaksa: klinicheskij i farmakojekonomicheskij aspekty / A.B. Geht, L.E. Mil'-chakova, E.I. Gusev // Zhurnal nevrologii i psihiatrii im. C.C. Korsakova. — 2007. — T. 107, № 12. — S.40— 45.
4. Muhin, K.Ju. Klinicheskaja jeffektivnost' i perenosimost' topamaksa pri kombinirovannoj terapii jepilepsii / K.Ju. Muhin, A.S. Petruhin, M.B. Mironov // Zhurnal nevrologii i psihiatrii im. S.S. Korsakova. — 2003. — T. 103, № 3. — S.28—33.
5. Sravnitel'naja jeffektivnost' i perenosimost' to-piramata, val'proatov i karbamazepina v monoterapii jepilepsii u detej i molodyh vzroslyh / K.Ju. Muhin, M.D. Tysjachina, L.N. Muhina [i dr.] // Russkij zhurnal detskoj nevrologii. — 2008. — T. 3, № 2. — S.3— 48.
6. Nikanorova, M.Ju. Farmakorezistentnye jepilepsii u detej / M.Ju. Nikanorova, E.D. Belousova, A.Ju. Ermakov, V.S. Perminov // Rossijskij medicinskij zhurnal. — 2002. — № 2. — C.43—44.
7. Perunova, N.Ju. Jeffektivnost' lamiktala v lechenii rezistentnyh form jepilepsii / N.Ju. Perunova, E.V. So-rokova, A.S. Shershever // Russkij zhurnal detskoj nevrologii. — 2006. — T. 1, № 1. — C.33—37.
8. Jeffektivnost' i perenosimost' dopolnitel'noj terapii lamiktalom pri jepilepsii u zhenshhin / M.B. Mironov, A.S. Petruhin, K.Ju. Muhin [i dr.] // Jepilepsija. Prilozhenie k Zhurnalu nevrologii i psihiatrii im. S.S. Korsakova. — 2006. — Vyp. 1. — S.59—63.
9. Al Ajlouni, S. The effcacy and side effects of topiramate on refractory epilepsy in infants and young children: a multi-center clinical trial / S. Al Ajlouni, A. Shorman, A.S. Daoud // Seizure. — 2005. — Vol. 14, № 7. — P.459—463.
10. Comparative effectiveness of 10 antiepileptic drugs in older adults with epilepsy / H. Arif R. Buchsbaum, J. Pierro [et al.] // Arch. Neurol. — 2010. — Vol. 67, № 4. — P.408—415.
11. Conversion from carbamazepine or oxcarbazepine to topiramate in adolescents and adults with epilepsy / A. Kowalik, W. Rimpau, H. Adam [et al.] // Acta Neurol. Scand. — 2008. — Vol. 117, № 3. — P.159—166.
12. Conversion from valproic acid onto topiramate in adolescents and adults with epilepsy / A. Schreiner, K. Stolhoff, W. Ossig [et al.] // Acta Neurol. Scand. — 2009. — Vol. 119, № 5. — P.304—312.
13. Effcacy and safety of topiramate in infants according to epilepsy syndromes / S. Grosso, D. Galimberti, M.A. Farnetani [et al.] // Seizure. — 2005. — Vol. 14, № 3. — P.183—189.
14. Effcacy and safety of topiramate in refractory epilepsy of childhood: long-term follow-up study / S. Grosso, E. Franzoni, P . Iannetti [et al.] // J. Child. Neurol. — 2005. — Vol. 20, № 11. — P.893—897.
15. Long-term effects of levetiracetam and topiramate in clinical practice: A head-to-head comparison / H.P. Bootsma, L. Ricker, L. Diepman [et al.] // Seizure. — 2008. — Vol. 17, № 1. — P.19—26.
16. Long-term effcacy and tolerability of topiramate as add-on therapy in refractory partial epilepsy: an observational study / Y.J. Cho, K. Hto, W.J. Kim [et al.] // Epilepsia. — 2009. — Vol. 50, № 8. — P.1910—1919.
17. Topiramate in add-on therapy: results from an open-label, observational study / K. Krakow U. Lengler, K. Rettig [et al.] // Seizure. — 2007. — Vol. 16, № 7. — P.593—600.
18. The efficacy and tolerability of lamotrigine adjunctive/ monotherapy in patients with partial seizures refractory to poly-AEDs / Ch. Song, H. Chen, W.X. Xiaoyong [et al.] // J. of Nanjing Medical University. — 2009. — Vol. 23, issue 5. — P.322—327.
19. Zubcevic, S. Use of lamotrigine in medically intractable epilepsies in children / S. Zubcevic, A. Cengic, F. Catibusic, S. Uzicanin // Med. Arh. — 2008. — Vol. 62, № 3. — P.162— 164.
FEATURE LONG-CHAIN POLYUNSATURATED FATTY ACIDS NEWBORN AT RISK AND THEIR MOTHERS
VALERY V. SOFRONOV, EVGENIA A. AGAFONOVA, DIANA .I. SHEGUROVA, OLGA V. SHARIPOVA, ANNA A. BABINTSEVA, NELLY A. ABRAMZON
Аbstract .This article analyzes the content of LCPUFA: arachidonic acid (AA) and docosahexaenoic acid (DHA) in the serum of newborns and their mothers. Determination of fatty acids was carried out by gas chromatography method. Found that for miscarriage occurs on a 3-fold reduction of DHA with a parallel increase in the content of AA. Transplacental transport of fatty acids is biased towards preferential accumulation in the body of the fetus \ newborn AK.
Key words: newborn baby, new mother, arachidonic acid, docosahexaenoic acid, gas chromatography.
LiteRatURa
1. Akberova, N.I. Sravnenie dannyh. Neparametricheskie kriterii znachimosti / N.I. Akberova // Metodicheskoe rukovodstvo i sbornik zadach k prakticheskim zanjatija po kursu «Matematicheskie metody v biohimii». — 2004.
2. Auestad, N. Visual Acuity. RBC Fatty Acids and Growthin Term Infants Fed Formulas With and Without Long-Chain Polyunsaturated Fatly Acid (LCP) / N. Auestad, M.B. Montalto, R.E. Wheeler // Fed. Res. — 1995. — Vol. 37. — P.302.
3. Dutta-Roy, A.K. Transport mechanisms for long-chain polyunsa-turated fatty acids in the human placenta / A.K. Dutta-Roy // Am. J. Clin. Nutr. — 2000. — Vol. 71. — P.315—322.
4. Field, C.J. Polyunsaturated fatty acids and T-cell function: implication for the neonate / C.J. Field, M.T. Clandinin, J.E Van Aerde // Lipids. — 2001.
5. Innis, S.M. Essential fatty acid metabolism in infants / S.M. 1nnis, N. Hrboticky, K.D. Foote // Nutrition. — 1989. — Vol. 4. — P.256—258.
6. Innis, S.M. Development of Visual Acuity in Relation to Plasma and Erythrocyte co-6 and co-3 Fatty Acids in Healthy Term Gestation Infants / S.M. Innis // Am. J. Clin. Nutr. — 1994. — Vol. 60. — P.347—352.
7. Neuringer, M. Infant vision and retinal function in studies of dietari long-chain polyunsaturated fatty acids: methods, results and implication / M. Neuringer // Am. J. Clin. Nutr. — 2000. — Vol. 71. — P.256—267.
8. Seyberth, H.W. The role of eicosanoids in paediatrics / H.W. Seyberth, P.G. Kuhl // Eur. J. Paediatr. — 1988. — Vol. 147. — P.341—349.
9. Spector, A.A. Membrane lipid composition and cellular function / A.A. Spector, M.A. Yorek // J. Lipid. Res. — 1985. — Vol. 26. — P.1015—1035.
MEDICINES OF PYRIMIDINE'S ROW
IN EXPERIMENTAL AND CLINICAL RESEARCHES
AIDA H. IZMAYLOVA, DILYARA H. SHAKIROVA, ALEXANDER G. IZMAYLOV
Abstract. In the review of literature there is the analysis of the publications devoted to researches on application of medicines of a pyrimidine’s row in experiments and clinic. The received results testify to a wide range of action of this class of medicines, the basic ones are stimulation of regenerative processes, immunotropic and anti-infammatory actions. Now among preparations of the pyrimidine’s row there is Xymedon, developed by the experts in Kazan. Key words: pyrimidine’s derivatives, Xymedon, methyluracilum, oxymethyluracilum, anti-infammatory, antioxidant and immunostimulating actions.
LiteRatURa
1. Abdulhakov, R. A. Sovremennye principy lechenija jazvennoj bolezni. / R.A. Abdulhakov // Kazanskij medicinskij zhurnal. — 2002. — T. 83, № 3. — S.233—236
2. Bodrova, R.A. Lechenie sistemnoj sklerodermii ksi-medonom / R.A. Bodrova, I.G. Salihov, L.E. Ziganshina // Kazanskij medicinskij zhurnal. — 2002. — № 5. — S.348—351.
3. Borisova, A.M. Kliniko-immunologicheskaja jeffektivnost' primenenija oksimetiluracila u bol'nyh vtorichnym immunodeficitnym sostojaniem / A.M. Borisova, I.H. Sitdikova, B.V. Pinegin // Immunologija. — 1994. — № 5. — S.48—50.
4. Vlasov, A.P. Vlijanie antioksidantov na jendotoksikoz pri jeksperimental'nom peritonite / A.P. Vlasov, T.V. Tarasova, G.I. Sudakova [i dr.] // Jeksperimental'naja i klinicheskaja farmakologija. — 2000. — № 6. — S.58—61.
5. Galiullina, L.A. Kliniko-immunologicheskaja ocenka jeffektivnosti ksimedona v lechenii psoriaza / L.A. Ga-liullina, R.H. Hafiz'janova // Vestnik dermatologii i venerologii. — 1999. — № 4. — S.38—39.
6. Giljazov, I.R. Primeneie oksimetiluracila v kompleksno lechenii pacientov pozhilogo i starcheskogo vozrasta s hronicheskoj obstruktivnoj bolezn'ju legkih / I.R. Gilja-zov, M.M. Fazlyev // Kazanskij medicinskij zhurnal. — 2008. — № 6. — S.751—755.
7. Dobrokvashin, S.V. Sposob lechenija jazvennoj bolezni zheludka i dvenadcatiperstnoj kishki / S.V. Dobrokvashin, O.K. Pozdeev, R. R. Jakupov, L.G. Morozova // Patent RF № 2250767. — 2005.
8. Zaikonnikova, I.V. Ksimedon — lekarstvennoe sredstvo. Istorija sozdanija / I.V. Zaikonnikova, N.G. Gabdrahmano-va, S.M. Gorbunov // Farmakologija i toksikologija fosfo-rorganicheskih i biologicheskih aktivnyh veshhestv. — Kazan': Marijskij poligraf. — 1996. — № 2. — S.81.
9. Ibragimov, O.B. Jeksperimental'noe obosnovanie primenenija ksimedona v kachestve antiateroskleroticheskogo lekarstvennogo sredstva. avtoreferat. dis. … kand. med. nauk / O.B. Ibragimov. — Kazan', 1994. — 21 s.
Izmajlov, S.G. Ksimedon: nastojashhee i budushhee / S.G. Izmajlov, V.V. Parshikov // Nizhegorodskij medicinskij zhurnal. — 2002. — № 3. — S.81—87.
11. Izmajlov, S.G. Doklinicheskoe issledovanie ksimedona / S.G. Izmajlov, S.M. Gorbunov, G.A. Izmajlov [i dr.] // Antibiotiki i himioterapija. — 1999. — № 8. — S.12—17
12. Il'jasova, G.F. Immunomorfologicheskie i gistohimicheskie izmenenija v organah i tkanjah krys, privityh vakcinami psevdobeshenstva na fone primenenija ksi-medona / G.F. Il'jasova // Morfologija. — 1998. — T. 113, № 3. — S.53.
13. Kamilov, F.H. Pirimidiny i ih primenenie v medicine / F.H. Kamilov, D.N. Lazareva, V.V. Plechev. — Ufa: BGMI, 1992. — 158 s.
14. Karkishhenko, N.N. Pirimidiny. Obzor literatury / N.N. Karkishhenko, Zh.N. Aslanjanc // Farmakologija i toksikologija. — 1989. — № 6. — S.100—105.
15. Kochnev, O.S. Ksimedon kak stimuljator reparativnoj regeneracii v hirurgicheskoj praktike / O.S. Kochnev, S.G. Izmajlov // Kazanskij medicinskij zhurnal. — 1990. — № 5. — S.373—375.
16. Kravchenko, I.Je. Ocenka metabolicheskih sistem aceti-lirovanija i okislenija u bol'nyh streptokokkovymi anginami i ih terapevticheskaja korrekcija ksimedonom / I.Je. Kravchenko, S.Ju. Garmonov, R.G. Zaripova [i dr.] // Kazanskij medicinskij zhurnal — 2008. — № 4. — S.452—457.
17. Ksimedon v klinicheskoj praktike: nauch. izdanie / S.G. Izmajlov, G.A. Izmajlov, V.S. Reznik [i dr.]; Voen. med. in-t Feder. pogran. sluzhby RF pri Nizhegorod. gos. med. akad. — N. Novgorod: NGMA, 2001. — 188 s.
18. Ksimedon v kompleksnom lechenii bol'nyh s jazvennymi gastroduodenal'nymi krovotechenijami / R. R. Jakupov, S.V. Dobrokvashin, O.K. Pozdeev [i dr.] // Kazanskij medicinskij zhurnal. — 2005. — № 3. — S.207—209.
19. Lazareva, D.N. Stimuljatory immuniteta / D.N. Lazareva, E.K. Alehin. — M.: Medicina, 1985. — 256 s.
20. Lazareva, D.N. Immureg / D.N. Lazareva, E.K. Alehin, V.V. Plechev [i dr.]. — Ufa: Bashkirskij gosudarstvennyj medicinskij universitet, 2004. — S.17—40.
21. Lazareva, D.N. Protivovospalitel'noe i protivojazvennoe dejstvie oksimetiluracila / D.N. Lazareva, V.A. Davydova // Jeksperimental'naja i klinicheskaja farmakologija. — 2005. — № 4. — S.53—55.
22. Lazarev, N.V. Pentoksil i ego primenenie pri alejkijah / N.V. Lazarev, G.I. Felistovich. — M.: MEDGIZ, 1954. — 120 s.
23. Madykenov, O.M. Immunologicheskaja reaktivnost' bol'nogo pri ozhogovoj bolezni / O.M. Madykenov, A.I. Ne-dorezova // Zdravoohranenie Kazahstana. — 1981. — № 12. — S.42—43.
24. Malyshev, K.V. Antioksidantnaja terapija ksimedonom u bol'nyh s hronicheskim osteomielitom / K.V. Malyshev // Vestnik hirurgii im. I.I. Grekova. — 2000. — T. 159, № 4. — S.59—63.
25. Myshkin, V.A. Oksimetiluracil (ocherki jeksperimental'noj farmakologii) / V.A. Myshkin, A.B. Bakirov. — Ufa: Dar, 2001. — 218 s.
26. Pikuza, A.H. Antiokislitel'naja aktivnost' syvorotki krovi i sleznoj zhidkostiu bol'nyh posle jekstrakcii katarakty i vozmozhnosti ee korrekcii ksimedonom / A.H. Pikuza, M.V. Kuznecova, L.E. Ziganshina [i dr.] // Kazanskij medicinskij zhurnal. — 2007. — T. 88, № 4. — S.370—373.
27. Primenenie ksimedona v klinicheskoj praktike: metod. rek. dlja vrachej (nauch. obzor klin. issled.) / sost. prof. V.H. Fazylov [i dr.]; pod red. prof. V.H. Fazylova. — Kazan', 2010. — 40 s.
28. Patent RF № 2082402 RF. Sposob stimulirovanie zazhivlenie ran / S.G. Izmajlov // Zajavleno 26.05.1993 g. Opublikovano 27.06.1997.
29. Patent RF № 2029563 RF. Sredstvo dlja zashhity ran / O.S. Kochnev, S.G. Izmajlov, V.S. Reznik // Zajavleno 21.07.1992 g. Opublikovano 27.02.1995.
30. Patent RF № 2054937 RF. Sposob lechenija ostryh pnevmonij / D.A. Valimuhametova, A.P. Cibul'kin, Ju.D. Slab-nov, R.F. Hamitov // Zajavleno 05.04.1990 g. Opublikovano 27.02.1996.
31. Patent RF № 2088231 RF. Sposob lechenija tuberkuleza legkih / Ju.D. Slabnov, O.V. Firsov, A.A. Vizel' Zajavleno 22.02.1995 g. Opublikovano 27.08.1997.
32. Raginov, I.S. Vlijanie ksimedona na potencial-zavisimye Sa2+-toki v piramidnyh nejronah jentorenal'-nogo korteksa / I.S. Raginov, G.V. Cherepnev, R.S. Garaev // Jeksperimental'naja i klinicheskaja farmakologija. — 2006. — T. 69, № 1. — S.18—20.
33. Reznik, V.S. Vzaimodejstvie oksi i merkaptopirimi-dinov s jetilen i propilenhlorgidrinami / V.S. Reznik, N.G. Pashkurov // Izvestija AN SSSR. — 1966. — № 91. — S.13. — (Ser. Himija).
34. Sakaeva, D.D. Oksimetiluracil kak korrektor oslozhnenij himioterapii zlokachestvennyh opuholej / D.D. Sakaeva // Jeksperimental'naja i klinicheskaja farmakologija. —
2004. — № 1. — S.51—53.
35. Slabnov, Ju.D. Korrekcija pirimidinovymi proizvodnymi immunologicheskoj reaktivnosti organizma i funkcii vneshnego dyhanija dlja profilaktiki zatjazhnogo techenija ostryh pnevmonij / Ju.D. Slabnov, D.A. Valimuhametova, A.P. Cibul'kin [i dr.] // Kazanskij medicinskij zhurnal. — 1993. — T. 74, № 3. — S.193—197.
36. Slabnov, Ju.D. Mehanizmy sistemnogo immunomodu-lirujushhego dejstvija pirimidinovyh proizvodnyh / Ju.D. Slabnov, G.V. Cherepnev, A.P. Cibul'kin [i dr.] // Jeksperimental'naja i klinicheskaja farmakologija. — 1997. — № 3. — S.65—67.
37. Tereshhenko, V.Ju. Ispol'zovanie ksimedona v lechenii hronicheskogo osteomielita / V.Ju. Tereshhenko, K.V. Malyshev // Farmakologija i toksikologija biologicheski aktivnyh veshhestv. — 1996. — № 2. — S.132.
38. Hafiz'janova, R.H. Vlijanie ksimedona na regeneraciju perifericheskogo nerva / R.H. Hafiz'janova, I.S. Ragi-nov, A.Ju. Vafin [i dr.] // Tez. dokl. Ros. konf., posvjashh. 75-letiju prof. I.V. Zaikonnikovoj. — Kazan', 1996. — Vyp. 3. — S.145.
39. Hitrov, V.Ju. Primenenie ksimedona v kompleksnom lechenii hronicheskogo kataral'nogo gingivita u detej, bol'nyh saharnym diabetom. Aktual'nye voprosy diagnostiki i lechenija / V.Ju. Hitrov. — Kazan'. Marijskij poligrafkombinat, 1997. — S.92.
40. Cibul'kin, A.P. Lechenie ksimedonom bol'nyh pollinozom / A.P. Cibul'kin, M.I. Hasanova, V.N. Cibul'kina // Kazanskij medicinskij zhurnal. — 1998, № 5. — S.349—353.
41. Cibul'kin, A.P. Immunoreguljatornye vzaimodejstvija v sisteme Th1-Th2-limfocitov — osnova razvitija kak patologicheskogo processa, tak i terapevticheskogo jeffekta ksimedona u pacientov s atopicheskimi allergicheskimi zabolevanijami / A.P. Cibul'kin, O.V. Skorohodkina, N.A. Cibul'kin // Kazanskij medicinskij zhurnal. —
2005. — № 2. — S.87—91.
42. Chelyshev, I.A. Medikamentoznaja stimuljacija regeneracii perifericheskih nervov / I.A. Chelyshev, R.K. Hafizova, I.S. Raginov [i dr.] // Jeksperimental'naja i klinicheskaja farmakologija. — 2000. — № 4. — S.17—19.
43. Cherepnev, G.V. Potencial'naja rol' antimutagennogo jeffekta ksimedona v modifikacii immunoreaktivnosti / G.V. Cherepnev, K.V. Malyshev, Ju.D. Slabnov [i dr.] // Jeksperimental'naja i klinicheskaja farmakologija. — 2000. — № 6. — S.43—48.
44. Shafikov, I.Z. Primenenie ksimedona v lechenii obozhzhennyh / I.Z. Shafikov, G.A. Izmajlov, S.G. Izmajlov [i dr.] // Hirurgija. — 1993. — № 4. — S.62—66.
45. Jusupova, L.A. Lechenie bol'nyh jekzemoj / L.A. Jusupova, R.H. Hafiz'janova // Rossijskij zhurnal kozhnyh i venericheskih boleznej. — 2005. — № 6. — S.20—23.
46. Jagudina, L.A. Ksimedon jeffektiven v kompleksnom lechenii bol'nyh s posttravmaticheskimi gnojno-vospalitel'nymi oslozhnenijami / L.A. Jagudina, L.E. Zi-ganshina, A.P. Cibul'kin // Klinicheskaja farmakologija i terapija. — 2005. — № 2. — S.94—96.
XYMEDON EXPERIENCE OF THERAPY IN COMPLEX CAP IN SCHOOL — AGE CHILDREN
IRINA V. SITDIKOVA, FARIDA S. PIROGOVA, AIDA H. IZMAILOVA, OLGA I. PIKUZA, ELMIRA D. KASHAFOVA, ILDARIA H.VALEEVA, INNA V. RUSAKOVA
Abstract. The purpose of the study — to examine the effectiveness of xymedon in the treatment of community-acquired pneumonia in children of school age. Material and methods. We observed 103 children aged 7 to 17 years, who were divided into 3 groups: group 1 — in addition to conventional therapy received xymedon (37 children ), the group 2 — in the complex therapy was part metiluratsil (34 children ), the group comparison — conventional therapy (32 children ) . The effectiveness of treatment was assessed by clinical parameters , indicators of the general analysis of blood, the level of malondialdehyde and total antioxidant activity in saliva. Results and discussion. It was determined that the number of children at one clinical and laboratory parameters to normalize earlier than patients of other study groups. Conclusion. Appointment of domestic preparation of pyrimidine series xymedon in the complex therapy of community-acquired pneumonia in children of school age accelerates the timing of clinical recovery. Keywords: xymedon, metiluratsil, community-acquired pneumonia, children of school age.
LiteRatURa
1. Aznabaeva, Ju.G. Antioksidantnye svojstva chajnyh napitkov firmy «Travy Bashkirii» / Ju.G. Aznabaeva, R. R. Kaspranskij, R. R. Farhutdinov // Jefferentnaja terapija. — 2001. — № 2. — S.52—56.
2. Volkov, I.K. Optimal'nyj vybor terapii pri vnebol'-nichnoj pnevmonii u detej / I.K. Volkov, N.A. Geppe, A.B. Malahov [i dr.] // Lechashhij vrach. — 2011. — №1. — S.50-53.
3. Kozlov, R.S. Sostojanie antibiotikorezistentnosti pnevmokokkov v Rossii: 1999—2009 gg. / R.S. Kozlov. // Bolezni i antibiotiki. — 2010. — № 1. — S.19—23.
4. Pikuza, A.H. Klinicheskoe znachenie mestnyh pokazatelej perekisnogo okislenija lipidov i antioksidantnoj zashhity u bol'nyh posle jekstrakcii katarakty / A.H. Pikuza, M.V. Kuznecova, L.E. Ziganshina, I.H. Valeeva // Vestnik oftal'mologii. — 2008. — № 1. — S.19—22.
5. Pikuza, O.I. Osobennosti sostojanija kletochnyh membran pri razlichnyh kliniko-morfologicheskih variantah vnebol'nichnyh pnevmonij u detej-shkol'nikov / O.I. Pi-kuza, A.M. Zakirova, H.M. Vahitov [i dr.] // Pediatrija. — 2013. — № 3. — S.18—20.
6. Tereshhenko, V.Ju. Ispol'zovanie ksimedona v lechenii hronicheskogo osteomielita / V.Ju. Tereshhenko, K.V. Malyshev // Farmakologija i toksikologija biologicheski aktivnyh veshhestv. — 1996. — № 2. — S.132.
7. Jagudina, L.A. Ksimedon jeffektiven v kompleksnom lechenii bol'nyh s posttravmaticheskimi gnojno-vospalitel'nymi oslozhnenijami / L.A. Jagudina, L.E. Zi-ganshina, A.P. Cibul'kin // Klinicheskaja farmakologija i terapija. — 2005. — № 2. — S.94—96
8. Frei, B. Antioxidant defenses and lipid peroxidation in human blood plasma / B. Frei // Proc. Hatl. Acad. Aci. USA. — 1988. — № 85 (24). — P.9748—9752.
A CASE OF ULCERATIVE COLITIS WITH THE PREVALENCE
OF EXTRACOLONIC MANIFESTATIONS — SPONDYLOARTHRITIS
AND INFLAMMATORY PSEUDOTUMOR
VALERY Y. SHAPIRO, ILDOUS Y. LUTFULLIN, SVETLANA Y. YUMASHEVA, ASIA I. SAFINA
Abstract. The article is devoted to extracolonic manifestations of ulcerative colitis. A case of ulcerative colitis with
spondiloarthritis and infammatory pseudotumor is given.
Key words: ulcerative colitis, spondiloarthritis, infammatory pseudotumor.
1. Vospalitel'nye psevdoopuholi tolstoj kishki / S.A. Pyshkin, D.L. Borisov, D.N. Dzhinchveladze [i dr.] // Annaly hirurgii. — 2008. — № 4. — S.36.
2. Rekomendacii po diagnostiki i lecheniju vzroslyh bol'nyh jazvennym kolitom, 2013 g. / V.T. Ivashkin, Ju.A. Shelygin, D.I. Abdulganieva [i dr.] — URL: http://obshhestvo-hirurgov.rf/stranica-pravlenija/kliniches-kie-rekomendaci/koloproktologija/klinicheskie-rekomendaci-po-diagnostike-i-lecheniyu-vzroslyh-bolnyh-jazvenym-koli-tom.html svobodnyj
3. Infammatory pseudotumor of the alimentary tract: clinical and surgical experience / B.M. Sanders, K.W. West, S. Gingalewski [et al.] // J. Pediatr. Surg. — 2001. — Vol. 36, № 1. — R.169—173.
4. Infammatory pseudotumor of the liver associated with Crohn's disease / G.I. Papachristou, T. Wu, W. Marsh, S.E. Plevy // J. Clin. Gastroenterol. — 2004. — № 38 (9). — P.818—822.
5. Spontaneous regression of hepatic infammatory pseudo-tumor with primary biliary cirrhosis: case report and literature review / H. Koide, K. Sato, T. Fukusato, [et al.] // World J. Gastroenterol. — 2006. — № 12 (10). — P.1645— 1648.
6. Renzing, N. Inflammatory pseudotumours of the liver associated with Crohn’s disease: a possible pitfall in contrast-enhanced ultrasound / N. Renzing, M. Ebsen, W. Schwerk // Z. Gastroenterol. — 2011. — № 49 (7). — P.827—831.
7. Jaundice caused by a pancreatic mass: an exceptional presentation of Crohn’s disease / H. Reynaert, O. Peters, J. Van der Auwera [et. al] // J. Clin. Gastroenterol. — 2001. — № 32 (3). — P.255—258.
8. Armas Pérez, BA. Pseudotumor form of idiopathic ulcerative colitis / B.A. Armas Pérez, O. Zamora Santana, C. Boladeres
9. Infammatory pseudotumor of the spleen. Morphological, radiological, immunophenotypic, and ultrastructural features / B.I. Dalal, H. Greenberg, G.E. Quinonez, J.C. Gough // Arch. Pathol. Lab. Med. — 1991. — № 5 (10). — P.1062—1064.
10. Infammatory pseudotumor of spleen / P.H. Wiernik, M. Rader, N.H. Becker, S.F. Morris // Cancer. — 1990. — № 66 (3). — P.597—600.
11. Someren, A. «Inflammatory pseudotumor» of liver with occlusive phlebitis: report of a case in a child and review of the literature / A. Someren // Am. J. Clin. Pathol. — 1978. — № 69 (2). — P.176—181.
12. Infammatory pseudotumor of the spleen: A case report and review of published cases / Z.H. Ma, X.F. Tian, J. Ma, Y.F. Zhao // Oncol. Lett. — 2013. — № 5 (6). — P.1955—1957.
13. Cedoz, J.P. The B7 cross reactive group and spondylo-arthropathies: an epidemiological approach / J.P. Cedoz, D. Wendling, J.F. Viel // J. Rheumatol. — 1995. — № 22 (10). — P.1884—1890.
14. Reynolds, T.L. B7 crossreactive antigens in spondylo-arthropathies / T.L. Reynolds, M.A. Khan // Rheumatol. — 1988. — № 15 (9). — P.1454.
15. Alieva, Je.I. Bolezn' Krona u detej / Je.I. Alieva, V.G. Rumjancev // Pediatrija. — 2001. — № 6. — S.75—79.
16. Lejshner, U. Autoimmunnye mehanizmy pri hronicheskih vospalitel'nyh zabolevanijah kishechnika / U. Lejshner // Autoimmunnye zabolevanija pecheni i perekrestnyj sindrom. — Anaharsis , 2005. — 25 s.
COMPARATIVE OBSERVATION OF CHILDREN WITH ROP FOR YEARS 2011—2012 GAUSE «GDB № 1» OF KAZAN
MARINA V. POTAPOVA, GULSINA М. KHUZEYEVA, INDIRA I. SHAMSUTDINOVA, ELENA A.KUZMINA, OLGA V. SHARIPOVA
Abstract. The article covers the problem of increasing the number of premature infants with a violation of the cardiovascular system of the retina. In this paper the problem is studied on the materials of GAUSE «Children’s hospital № 1» of Kazan. Structure of the study was built on the consistent study of the data grouped in the table on certain grounds and analysis in mutual communication and causation. The analysis has revealed the problem is not formally refected in the similar tables, analyzed in isolation, namely the increase in the number of premature faster than the growth of the birth rate, the proportion of children with severe degree of retinopathy, a similar situation is observed with the degree of prematurity. Key words: Retinopathy of prematurity, operative intervention, the negative trend.
LiteRatURa
1. Tereshhenko, A.V. Rannjaja diagnostika i monitoring retinopatii nedonoshennyh / A.V. Tereshhenko, Ju.A. Belyj, I.G. Trifanenkova; pod red. H.P. Tahchidi. — Kaluga, 2008. — 84 s.: il.
2. Sajdasheva, Je.I. Izbrannye lekcii po neonatal'noj oftal'mologii / Je.I. Sajdasheva, E.E. Somov, I.V. Fomina. — SPb.: Izdatel'stvo «Nestor-Istorija», 2006. — 272 s.: il.
A CASE OF LIVER ABSCESS OF A NEWBORN BABY
KH. S. KHAERTYNOV, O. V. SHARIPOVA, A. A. PODSHIVALIN
Abstract. The article presents a case of liver abscess of a newborn baby. Considered the basic clinical and laboratory sings of liver abscess and risk factors for its development. Key words: newborn, liver abscess.
LiteRatURa
1. Abaev, Ju.K. Abscessy pecheni u novorozhdennyh / Ju.K. Abaev, V.I. Averin // Pediatrija, 2004. — № 1. — S.214—259.
2. Ahaladze, G.G. Abscessy pecheni / G.G. Ahaladze, I.Ju. Cereteli // Annaly hirurgicheskoj gepatologii. — 2006. — T. 11, № 1. — S.97—105.
3. Fievet, L. Management of pediatric liver abscess / L. Fievet, J.L. Michel, L. Harper [et al.] // Arch. Pediatr. — 2012. — Vol. 19 (5). — P.497—500.
4. Mannan, Kh. Liver abscess within the first week of life in a very low birthweight infant / Kh. Mannan, Sh. Tadros, K. Patel, N. Aladangady // BMJ Case Rep. — 2009. — Vol. 1874.
5. Moens, E. Hepatic abscesses associated with umbilical catheterisation in two neonates / E. Moens, J. De Dooy, H. Jansens [et al.] // European Journal of Pediatrics. — 2003. — Vol. 162, № 6. — P.406—409.
6. Salahi, R. Liver Abscess in Children: A 10-year Single Centre Experience / R. Salahi, S.M. Dehghani, H. Salahi [et al.] // Saudi J. Gastroenterol. — 2011. — Vol. 17 (3). — P.199—202.
7. Simeunovic, E. Liver abscess in neonates / E. Simeunovic, M. Arnold, D. Sidler, S.W. Moore // Pediatr. Surg. Int. — 2009. —Vol. 25 (2). — P.153—156.
8. Srivastava, A. Identifcation of high-risk group and therapeutic options in children with liver abscess / A. Srivastava, S.K. Yachha, V. Arora [et al.] // Eur. J. Pediatr. — 2012. — Vol. 171 (1). — P.33—41.
9. Tan, N.W. Neonatal Hepatic Abscess in Preterm Infants: A Rare Entity? / N.W. Tan, B. Sriram, A.P. Tan-Kendrick, V.S. Rajadurai // Annals Academy of Medecine. — 2005. — Vol. 34 (9). — P.558—564.
TREATMENT OF OSTEOPOROSIS IN PATIENTS WITH CONGENITAL DEFICIENCY OF VITAMIN K COMBINED-DEPENDED COAGULATION FACTORS (II, VII, IX, X, PROTEIN C AND PROTEIN S)
VALERI J. SHAPIRO, GULIA A. KHAMZINA, ASIA I. SAFINA, ASYA V. GALEEVA, ILDUS I. LUTFULLI.
Abstract. Article is devoted to treatment osteoporosis of in congenital defciency of vitamin of K-dependent factors of a coagulation. The disease is connected to congenital defciency of gamma carboxylase or enzyme vitamin K epokside reductaze. The lack of gamma carboxylation of osteocalcin — one of cementing factors — results in damage of linking of collagen with a mineral component of a bone. A case of congenital defciency of vitamin K combined — depended coagulation factors is given. Key words: vitamin K-dependent clotting factor defciency, osteoporosis, gamma-carboxylation of osteocalcin.
LiteRatURa
1. James, D.F. Clinical studies on dicumarol hypoprothrombinemia and vitamin K preparations / D.F. James // Arch. Intern. Med. — 1949. — № 83. — P.632.
2. Udall, J.A. Don’t use the wrong vitamin K / J.A. Udall // Calif. Med. — 1970. — № 112. — P.65—67.
3. Barkagan, Z.S. Gemorragicheskie zabolevanija i sindromy / Z.S. Barkagan — M.: Medicina, 1988. — S.273.
4. Weber, P. Management of osteoporosis: is there a role for vitamin K? / P. Weber // Int. J. Vitam. Nutr. Res. — 1997. — № 67 (5). — P.350—356.
5. Mohsin, R. Prevalence of vitamin K deficiency in cystic fbrosis / R. Mohsin // American Journal of Clinical Nutrition. — 1999. — Vol. 7, № 70. — P.378—382.
6. Krzyzanowska, P. Vitamin K status in cystic fbrosis patients / P. Krzyzanowska, I. Walkowiak; Poznan University of Medical Sciences // Acta Sci. Pol., Technol. Aliment. — 2010. — № 9 (4). — P.463—467.
7. Nicolaidou, P. The effect of vitamin K supplementation on biochemical markers of bone formation in children and adolescents with cystic fbrosis / P. Nicolaidou, I. Stavrinadis, I. Loukou // Eur. J. Pediatr. — 2006. — № 165. — P.540— 545.
8. Fewtrell, M.S. Undercarboxylated osteocalcin and bone mass in 8—12 year old children with cystic fbrosis / M.S. Fewtrell, C. Benden, J.E. Williams [et al.] // J. Cyst. Fibros. — 2008. — № 7. — P.307—312.
9. Conway, S.P. Vitamin K status among children with cystic fbrosis and its relationship to bone mineral density and bone turnover / S.P. Conway, S.P. Wolfe, K.G. Brownlee [et al.] // Pediatrics. — 2005. — Vol. 115, № 5. — P.1325—1331.
10. Hoorn, J.H. Vitamin K supplementation in cystic fbrosis / J.H. Hoorn , J.J. Hendriks, C. Vermeer, P.P. Forget // Arch. Dis. Child. — 2003. — № 88. — P.974—975.
11. Gage, B.F. Risk of osteoporotic fracture in elderly patients taking warfarin results from the national registry of atrial fbrillation / B.F. Gage, E. Birman-Deych, M.J. Radford [et al.] // Arch. Intern. Med. — 2006. — № 166 (2). — P.241—246.
12. Jamal, S.A. Warfarin use and risk for osteoporosis in elderly women. Study of Osteoporotic Fractures Research Group / S.A. Jamal , W.S. Browner, D.C. Bauer [et al.] // Ann. Intern. Med. — 1998. — № 128 (10) — P.829—832.
13. Barnes, C. Reduced bone density in children on long-term warfarin / C. Barnes, F. Newall, V. Ignjatovic [et al.] // Pediatr. Res. — 2005. — № 57 (4). — P.578—581.
14. Lafforgue, P. Bone mineral density in patients given oral vitamin K antagonists / P. Lafforgue, L. Daver, J.R. Monties [et al.] // Rev. Rhum. Engl. Ed. — 1997. — № 64 (4). — P.249—254.
15. Pilon, D. Oral anticoagulants and the risk of osteoporotic fractures among elderly / D. Pilon, A.M. Castilloux, M. Dorais, J. LeLorier // Pharmacoepidemiol Drug. Saf. — 2004. — № 13 (5). — P.289—294.
16. McMillan, C.W. Congenital combined defciency of coagulation factors II, VII, IX, and X — report of a case / C.W. McMillan, H.R. Roberts // N. Engl. J. Med. — 1966. — № 274. — P.1313—1315.
17. Bhattacharyya, J. Congenital vitamin K-dependent coagulation factor defciency: a case report / J. Bhattacharyya, P. Dutta, P. Mishra [et al.] // Blood Coagul Fibrinolysis. — 2005. — № 16. — P.525—527.
18. Darghouth, D. Compound heterozygosity of novel mis-sense mutations in the gamma-glutamyl carboxylase gene causes hereditary combined vitamin K-dependent coagulation factor defciency / D. Darghouth, K.W. Hallgren, R.L. Shtofman [et al.] // Blood. — 2006. — № 108. — P.1925—1931.
19. Pauli, R.M. Association of congenital defciency of multiple vitamin K-depen-dent coagulation factors and the phenotype of the warfarin embryopathy: clues to the mechanism of ter-atogenicity of coumarin derivatives / R.M. Pauli, J.B. Lian, D.F. Mosher, J.W. Suttie // Am. J. Hum. Genet. — 1987. — № 41. — P.566—583.
20. Boneh, A. Hereditary deficiency of vitamin K-dependent coagulation factors with skeletal abnor-malities / A. Boneh, J. BarZiv // Am. J. Med. Genet. — 1996. — № 65. — P.241—243.
21. Wu, S.M. Identifcation and purifcation to near homogeneity of the vitamin K-dependent carboxylase / S.M. Wu, D.P. Morris, D.W. Stafford // Proc. Natl. Acad. Sci. USA. — 1991. — № 88. — P.2236—2240.
22. Wu, S.M. Cloning and expression of the cDNA for human gamma-glut-amyl arboxylase / S.M. Wu, W.F. Cheung, D. Frazier, D.W. Stafford // Science. — 1991. — № 254. — P.1634—1636.
23. Rost, S. Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor defciency type 2 / S. Rost, A. Fregin, V. Ivaskevicius [et al.] // Nature. — 2004. — № 427. — P.537—541.
24. Li, T. Identifcation of the gene for vitamin K epoxide reductase / T. Li, C.Y. Chang, D.Y. Jin [et al.] // Nature. — 2004. — № 427. — P.541—544.
25. Weston, B.W. Familial defciency of vitamin K-dependent clotting factors / B.W. Weston, P.E. Monahan // Haemophilia. — 2008. — № 14 (6). — P.1209—1213.
NEW HORIZONS IN MOTHER CARE
AND OBSERVATION OF PREMATURE CHILDREN
IN THE CHILDREN'S CITY HOSPITAL № 1
ELENA V. VOLYANYUK, GULSINA M. KHUZEEVA, ЕLENA A. KUZMINA, OLGA V. SHARIPOVA
Abstract. This article presents the main problems of premature infants discharged from the neonatal pathology department of Children’s Hospital № 1, the frst results of the center catamnesis premature babies. Key words: preterm infants, follow-up, rehabilitation activities.
LiteRatURa
1. Posledujushhee nabljudenie nedonoshennyh v klinike razvitija Universiteta Jemori (SShA) / A.I. Safina, I.Ja. Lut-fullin, N.L. Rybkina [i dr.] // Vestnik sovremennoj klinicheskoj mediciny. — 2013. — T. 6. — S.86—90.
2. Jacyk, G.V. Problemy i perspektivy vyhazhivanija novorozhdennyh s jekstremal'no nizkoj massoj tela / G.V. Jacyk // Vestnik RAMN. — 2008. — № 12. — S.41—44.
3. Jacyk, G.V. Vyhazhivanie i rannjaja reabilitacija detej / G.V. Jacyk, E.P. Bombardirova, O.V. Tresorukova // Lechashhij vrach. — 2007. — № 7. — S.23—27.
4. Sizun, J. Erly developmental care for preterm babies: a call for more research/ J. Sizun, B. Westrap // Arch. Dis. Child. Fetal and neonatal edition. — 2004. — Vol. 89. — R.384—388.
PROGNOSTIC SIGNIFICANCE OF THE NUCLEAR DNA OF LYMPHOCYTES AND EXTRACELLULAR DNA IN NEWBORNS WITH DIFFERENT GESTATIONAL AGE
DIANA I. SHEGUROVA, VALERY V. SOFRONOV, SERGEY A. LUBIN, ELENA V. MAVRINA
Abstract. Article is devoted to studying of features of parameters of nuclear and extracellular DNA at newborns of various gestational age in the early neonatal period for determination of features of formation of adaptic processes and the prognostic importance. Key words: nuclear DNA, extracellular DNA, newborns.
LiteRatURa
1. Sarkisov, D.S. Ocherki istorii obshhej patologii / D.S. Sarkisov. — M.: Medicina, 1993.
2. Narcissov, R.P. Diagnosticheskie i prognosticheskie vozmozhnosti klinicheskoj citohimii v pediatrii (lekcija) / R.P. Narcissov // Vestnik Gippokrata. — R n/Donu, 1998. — № 1. — S.10—26.
3. Talaev, V.Ju. Otklonenija v hode beremennosti i klinicheskoe sostojanie novorozhdennyh s povyshennoj chuvstvitel'nost'ju T-limfocitov k inducirovannomu aktivaciej
apoptozu / V.Ju. Talaev, E.B. Talaeva, I.E. Lebedeva [i dr.] // Immunologija. — 1999. — № 6. — S.46—49.
4. Talaev, V.Ju. Povyshennaja chuvstvitel'nost' T-limfocitov chasti novorozhdennyh k aktivacionnomu apoptozu. Svjaz' s zabolevanijami materi i rebenka / V.Ju. Talaev, E.B. Ta-laeva, I.E. Lebedeva [i dr.] // Nizhegorodskij med. zhurnal. — 1999. — № 2. — S.13—18.
5. Talaev, V.Ju. Svjaz' patologii beremennosti s harakterom otveta na aktivaciju T-limfocitov pupovinnoj krovi novorozhdennyh / V.Ju. Talaev, I.E. Lebedeva, E.B. Talaeva // Pediatrija. — 1999. — № 5. — S.110—111.
6. Sofronov, V.V. Izmenenie soderzhanija jadernoj i vnekletochnoj DNK u novorozhdennyh s klinicheskimi projavlenijami narushenija adaptacii v rannem neonatal'nom periode / V.V. Sofronov, N.O. Tuaeva, V.G. Vinter [i dr.] // Voprosy sovremennoj pediatrii. — 2006. — № 5 (6). — S.28—31.
7. Tuaeva, N.O. Vnekletochnaja DNK v krovotoke cheloveka. Biologicheskaja rol' vnekletochnoj DNK / N.O. Tuaeva, Z.I. Abramova, D.M. Mustafina // Uchenye zapiski Kazanskogo universiteta. — 2008. — Vyp. 150 (2). — S.59—70. — (Ser. Estestvennye nauki).
8. Gromada, N.E. Citokinovyj profil' i kolichestvennoe znachenie DNK v jadrah limfocitov perifericheskoj krovi u novorozhdennyh s gipoksicheskim perinatal'nym porazheniem central'noj nervnoj sistemy. / N.E. Gromada // Citokiny i vospalenie. — 2008. — T. 7, № 3. — S.14—18.
9. Boyum, A. Separation of leukocytes from blood and bone marrow / A. Boyum // Scand. J. Clin. Lab. Investig. — 1968. — 21 (Suppl. 97). — R.1—9.
10. Nicoletti, I. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and fow cytometry / I. Nicoletti, G. Migliorati, M.C. Pagliacci [et al.] // J. Immunol. Methods. — 1991. — Vol. 139. — P.271—280
11. Mannheim, B. Apoptosis and cell proliferation. 2nd ed. / B. Mannheim // GmbH: Biochemica. — 1998. — P.143.
12. Mac Closkey, T.W. Use of flow cytometric assay to quantitate apoptosis in human lymphocytes. / T.W. Mac Closkey, N. Oyaizi, M. Coronezi [et al.] // Clin. Immunol. Immunopathol. — 2004. — Vol. 71. — P.14—18
13. Babich, P.N. Primenenie sovremennyh statisticheskih metodov v praktike klinicheskih issledovanij. Soobshhenie tret'e. Otnoshenie shansov: ponjatie, vychislenie i interpretacija./ P.N. Babich, A.V. Chubenko, S.N. Lapach // Ukraїns'kij medichnij chasopis. — 2005. — № 2. — S.113—119.
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