Vol. 14 Issue 2 (2021)

VSKM 2021 N 2

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ORIGINAL RESEARCH

Interdisciplinary neurocognitive approach to the analysis of motor, cognitive, and emotional problems in children engaged in music: principles of neurocorrectionBelousova M.V. (Russia, Kazan),Merkulova V.A. (Russia, Kazan), Futina N.V. (Russia, Kazan), Shamsutdinova R.F. (Russia, Kazan) P. 7

Cognitive disorders analysis in children with diabetes mellitus type I depending on the stage of the disease Bykov Yu.V. (Russia, Stavropol) P. 12

Elevated IL-8 levels as a predictor of hemorrhagic disorders in premature infants Vorontsova I.A. (Russia, Kazan), Loskutova E.V. (Russia, Kazan), Vakhitov Kh.M. (Russia, Kazan), Vakhitova L.F. (Russia, Kazan), Valeeva I.Kh. (Russia, Kazan) P. 16

Market research on personal protective equipment: antiseptics Ibragimova G.Ya. (Russia, Ufa), Iksanova G.R. (Russia, Ufa), Muratolieva A.J. (Kyrgyz Republic, Bishkek) P. 21

Early and late complications of psycho-emotional overload in pediatric dentists Kazakova L.N. (Russia, Saratov), Davydova N.V. (Russia, Saratov), Naryzhnaya E.V. (Russia, Saratov), Tereshchuk O.S. (Russia, Saratov), Oleynikova N.M. (Russia, Saratov), Sayutina L.V. (Russia, Saratov) P. 26

Epidemiological study of epilepsy in the settlement of mashtaga of the Republic of Azerbaijan Magalov Sh.I. (Republic of Azerbaijan, Baku), Melikova Sh.Ya. (Republic of Azerbaijan, Baku),Asadova U.A. (Republic of Azerbaijan, Baku) P. 32

Coronavirus pandemic: experience of the first wave in the Nizhny Novgorod region Fedotov V.D. (Russia, Nizhny Novgorod), Tulichev A.A. (Russia, Nizhny Novgorod), Fedotova O.O. (Russia, Nizhny Novgorod), Dobrotina I.S. (Russia, Nizhny Novgorod), Shakurova D.N. (Russia, Nizhny Novgorod) P. 39

REVIEWS

Comparison of left ventricular contractility in silent myocardial ischemia by echocardiography and perfusion scintigraphy Abdrakhmanova A.I. (Russia, Kazan), Tsibulkin N.A. (Russia, Kazan), Amirov N.B. (Russia, Kazan) P. 47

Prognostic value of growth differentiation factor 15 (GDF-15) in myocardial infarction Sabirzyanova A.A. (Russia, Kazan), Galyvich A.S. (Russia, Kazan) P. 52

CLINICAL CASE

Idiopathic recurrent lumbosacral plexopathy (clinical case) Safina D.R. (Russia, Kazan) P. 56

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ORIGINAL RESEARCH

UDC 613.86-053.2:159.9:78

DOI: 10.20969/VSKM.2021.14(2).7-11

PDF download INTERDISCIPLINARY NEUROCOGNITIVE APPROACH TO THE ANALYSIS OF MOTOR, COGNITIVE, AND EMOTIONAL PROBLEMS IN CHILDREN ENGAGED IN MUSIC: PRINCIPLES OF NEUROCORRECTION

BELOUSOVA MARINA V., ORCID ID: orcid.org/0000-0002-8804-8118; C. Med. Sci., associate professor of the Department of psychotherapy and addictions of Kazan State Medical Academy – the branch of Russian Medical Academy of Postgraduate Education, Russia, 420061, Kazan, Ershov str., 49, tel. (843)272-41-51, e-mail: belousova.marina@mail.ru

MERKULOVA VERONICA A., faculty member of the Department of age psychology of Institute of Psychotherapy аnd Clinical Psychology, Russia, 127055, Moscow, 1st Miusskaya str., 22/24, build. 2, tel. 8-915-329-18-75, e-mail: vero.merkulova@yandex.ru

FUTINA NATALIA V., highly trained teacher of Children’s music school No 7 named after A.S. Klyucharev, Russia, 420061, Kazan, Kosmonavty str., 11b

SHAMSUTDINOVA REZEDA F., C. Med. Sci., high level certificate neurologist, the Head of the Department of Сhildren Hospital No 8 named after prof. A.Y. Rathner, Russia, 420061, Kazan, B. Galeev str., 11

Abstract. Aim. The aim of the study was to investigate common complaints in children learning music related to the feeling of motor stiffness, muscle discomfort, painful postural tension, dif culties in self-control, dif culty in differentiating body sensations, as well as – emotional dif culties before the performance, and cognitive dif culties arising from the study of music notation. Material and methods. Problems in learning have been analyzed from the position of the biopsychosocial approach proposed by G. Engel, with the de nition of the leading biomechanical (positional), cognitive, emotional-volitional and behavioral aspects in relation to the biological background, psychological problems, the degree of maturity and formation of higher mental functions, and the contribution of the social environment. Results and discussion. The results of the study allowed us to relate children’s learning dif culties to the biomechanical (positional) and neuropsychological mechanisms determining them, to propose methods of neurocorrection, and to demonstrate the need for an interdisciplinary medical-psychological-educational approach to the correction of these problems. Conclusion. Dif culties that arise in children while learning music have a complex nature and are an interdisciplinary problem that requires consolidation of efforts not only from a teacher and a student, but also, in some cases, from a psychotherapist, a psychologist, a neurologist, and an osteopath with active participation of parents.

Key words: learning dif culties, music, postural stress, neuropsychological mechanisms, higher mental functions, neurocorrection.

For reference: Belousova MV, Merculova VA, Futina NV, Shamsutdinova RF. Interdisciplinary neurocognitive approach to the analysis of motor, cognitive, and emotional problems in children engaged in music: principles of neurocorrection. The Bulletin of Contemporary Clinical Medicine. 2021; 14 (2): 7-11. DOI: 10.20969/VSKM.2021.14(2).7-11.

References

1. Belousova MV, Karpov AM, Prusakov VF, et al. Psihicheskoe zdorov’ esovremennyh shkol’nikov: raspoznavanie ugrozi perspektivy ih ustraneniya [Mental health of modern schoolchildren: recognition of threats and prospects for their elimination]. Prakticheskaya medicina [Practical medicine]. 2019; 4 (3): 16–21.

2. Zavadenko NN. Shkol’naya dezadaptaciya v nejro-pediatricheskoj praktik [School maladjustment in neuropediatric practice]. Praktika pediatra [Pediatrician practice]. 2011; 3: 60 – 70.

3. Nesterovsky YE, Zavadenko NN, Shipilov EM et al. Shkol’naya dezadaptaciya v praktike pediatra i nevrologa [School maladjustment in the practice of a pediatrician and neurologist]. Consilium Medicum [Consilium Medicum]. 2017; 2 (3): 28-33.

4. Engel, G. The Clinical Application of Biopsychosocial Model. The American Yournal of Psychiatry. 1980; 137 (5): 535-544.

5. Semenovich AV. Neyropsikhologicheskaya korrektsiya v detskom vozraste; Metod zameshchayushchego ontogeneza: uchebnoye posobiye, 8 izdanie [Neuro-psychological correction in childhood; The method of replacement ontogenesis: a tutorial, 8th ed]. Moskva: Genesis [Moscow: Genezis]. 2007; 474 p.

6. Wiesel TG. Osnovy neyropsikhologii: ucheb. dlya studentov VUZov [Fundamentals of neuropsychology: textbook for university students]. Moskva: AST Astrel Tranzitkniga [Moscow: AST Astrel Tranzitkniga]. 2005; 384 p.

7. Esin RG, et al. Bol’: printsipy terapii, bol’ v manual’noy meditsine, 2 izdanie [ Pain: principles of therapy, pain in manual medicine, 2nd revised edition]. Kazan: Ofsetnaya kompaniya [Kazan: Offset company]. 2008; 176 p.

8. Shamsutdinova RF. Klinicheskiye osobennosti myshechno-skeletnoy boli u detey i podrostkov v zavisimosti ot kharaktera staticheskikh i dinamicheskikh nagruzok [Clinical features of musculoskeletal pain in children andadolescents depending on the nature of static and dynamicloads]. Kazan’: KGMA [Kazan: Kazan State Medical Academy]. 2009; 24 p.

9. Bartashevich VV. Sheynyy miofastsial’nyy bolevoy sindrom (klinika, mekhanizmy razvitiya, lecheniye) [Cervical myofascial pain syndrome (clinical picture, mechanisms of development, treatment)]. Kazan’: KGMA [Kazan: Kazan State Medical Academy]. 2005; 48 p.

10. Ivanichev GA. Miofastsial’naya bol’: Monografiya [Myofascial pain: Monograph]. Kazan’: KGMA [Kazan: Kazan State Medical Academy]. 2007; 392 p.

 

UDC 616.379-008.64-053.6-06:616.8-009.83

DOI: 10.20969/VSKM.2021.14(2).12-15

PDF download COGNITIVE DISORDERS ANALYSIS IN CHILDREN WITH DIABETES MELLITUS TYPE I DEPENDING ON THE STAGE OF THE DISEASE

BYKOV YU. V., ORCID ID: 0000-0003-4705-3823; C. Med. Sci., assistant of professor of the Department of anesthesiology, resuscitation and emergency medicine of Stavropol State Medical University, Russia, 355017, Stavropol, Mir str., 310, +7-962-443-04-92, e-mail: yubykov@gmail.com

Abstract. Aim. The aim of the study was to estimation of possible cognitive de cits in adolescents with type I diabetes mellitus at different stages of the disease. Material and methods. The study involved 52 adolescents (14–18 years old) with a diagnosis of type I diabetes mellitus, con rmed by both clinical and laboratory tests, and the presence of central nervous system damage (from impaired consciousness to sopor), marked hyperglycemia and ketoacidosis. The control group consisted of 26 adolescents admitted for scheduled surgical treatment (conditionally healthy children). Study protocol: cognitive function was assessed using the «Montreal Cognitive Scale»: at stage 1 – when the state of diabetes mellitus was stabilized, after initial admission to the hospital (restoration of consciousness to a clear level), and at stage 2 – two months later, at rehospitalization for routine follow-up in adolescents. The control group of adolescents was tested upon admission to the hospital for scheduled treatment. The obtained data were processed using Statistica 10 software. Differences between the groups were considered signi cant at p<0,05. Results and discussion. Cognitivedysfunction in patients with diabetes mellitus was detected in both acute and delayed periods. Maximum manifestations of brain dysfunction in children with type I diabetes mellitus were observed exactly in the acute period upon stabilization of diabetes mellitus (restoration of consciousness level to clear, transfer from the intensive care unit to the endocrinology department). Cognitive dysfunction also persisted in children two months after discharge, at the stage of rehabilitation, although its severity was lower. The association between the severity of cognitive impairment, the duration of the disease, and the number of hospitalizations in the intensive care unit during the entire period of illness was revealed only for the acute period of the disease. Conclusion. The presented results con rm the hypothesis that the chronic course of type I diabetes in pediatric practice on the background of frequent exacerbations, manifested by ketoacidosis and hyperglycemia, leads to brain cell damage, which is manifested by brain dysfunction in the form of cognitive impairment throughout the course of the disease. In addition, it was found that the severity of cognitive impairment in adolescents with diabetes mellitus has a relationship with the number of hospitalizations to the intensive care unit and the duration of the disease (that is, with each subsequent hospitalization brain dysfunction increases), which can be explained by the gradual decompensation of neuroplasticity of the central nervous system.

Key words: diabetes mellitus, ketoacidosis, cognitive impairments, cerebral dysfunction.

For reference: Bykov YuV. Cognitive disorders analysis in children with diabetes mellitus type I depending on the stage of the disease. The Bulletin of Contemporary Clinical Medicine. 2021; 14 (2): 12-15. DOI: 10.20969/VSKM.2021.14(2).12-15.

References

1. Mayer-DavisEJ, Lawrence JM, Dabelea D, et al. SEARCH for Diabetes in Youth Study Incidence Trends of Type 1 and Type 2 Diabetes among Youths, 2002-2012. N Engl J Med. 2017; 376: 1419-1429.

2. Shiryaeva TYu, Andrianova EA, Suncov YuI. Dinamika osnovnyh epidemiologicheskih pokazatelej saharnogo diabeta 1 tipa u detej i podrostkov v Rossijskoj Federacii [Dynamics of main epidemiological characteristics of type 1 diabetes mellitus in children of the Russian Federation]. Saharnyj diabet [Diabetes mellitus]. 2013; 3: 21-29.

3. Maahs DM, West NA, Lawrence JM, et al Epidemiology of type 1 diabetes. Endocrinol Metab Clin North Am. 2010; 39: 481–497.

4. Pogrebnyak DN, Pogrebnyak SN, Kohanec DV. Vpervye vyyavlennyj saharnyj diabet 1 tipa u detej i podrostkov Belgorodskoj oblasti za 2018 god [Newly diagnosed type 1 diabetes mellitus in children and adolescents of the Belgorod region in 2018]. Alleya nauki [Alley of Science]. 2019; 1 (28): 414-419.

5. Reynolds K, Saydah SH, Isom S, et al. Mortality in Youth-Onset Type 1 and Type 2 Diabetes: The SEARCH for Diabetes in Youth Study. J Diabetes Complications. 2018; 32 (6): 545-549.

6. Shalimova A, Graff B, Gąsecki D, et al. Cognitive Dysfunction in Type 1 Diabetes Mellitus. J Clin Endocrinol Metab. 2019; 104 (6): 2239-2249.

7. Ryan CM. Diabetes, aging, and cognitive decline. Neurobiol. Aging. 2005; 26: 21–25.

8. Gaudieri PA, Chen R, Greer TF, et al. Cognitive function in children with type 1 diabetes a meta-analysis. Diabetes Care. 2008; 31: 1892–1897.

9. Chapova OI, Bolotova NV, Kac IV. Osobennosti porazheniya central’noj nervnoj sistemy u detej pri saharnom diabete 1-go tipa [The speci c features of central nervous system lesions in children with type 1 diabetes mellitus]. Problemy endokrinologii [Problems of Endocrinolog]. 2006; 1 (52): 11-14.

10. McMillan T, Wilson L, Ponsford J, et al. The Glasgow Outcome Scale – 40 years of application and re nement. Nat Rev Neurol. 2016; 12 (8): 477-485.

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12. Cameron FJ, Northam EA, Ryan CM. The effect of type 1 diabetes on the developing brain. Lancet Child Adolesc Health. 2019; 3 (6): 427-436.

 

UDC 616.151.5-053.31/.32-074

DOI: 10.20969/VSKM.2021.14(2).16-20

PDF download ELEVATED IL-8 LEVELS AS A PREDICTOR OF HEMORRHAGIC DISORDERS IN PREMATURE INFANTS

VORONTSOVA IRINA A., ORCID: 0000-0001-7248-0419; assistant of professor of the Department of paediatrics of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. 8-987-421-86-85, e-mail: vorontsova.irochka@yandex.ru

LOSKUTOVA EKATERINA V., ORCID: 0000-0002-1818-32344; assistant of professor of the Department of paediatrics of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. 8-987-421-86-85, e-mail: loskutovakate@mail.ru

VAKHITOV KHAKIM M., D. Med. Sci., professor of the Department of pediatrics of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. +7-917-278-03-78, e-mail: vhakim@mail.ru

VAKHITOVA LILIA F. ORCID: 0000-0002-3643-2302; C. Med. Sci., assistant of professor of the Department of paediatrics of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. 8-903-342-03-97, e-mail: vliliya@mail.ru

VALEEVA ILDARIA KH., ORCID: 0000-0002-1818-32344; D. Biol. Sci., senior researcher of Central Research Laboratory of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. 8-917-232-28-42, e-mail: rushan.valiev@kazangmu.ru

Abstract. Aim. The aim of the study was to nd the relationship between changes in the level of interleukin 8 (IL-8) and changes in the main indicators of the blood coagulation system. Material and methods. Thirty-eight newborn infants were enrolled in the study. The rst (study) group included 17 premature infants with increased risk of haemorrhagic disorders. The second control group included full-term infants. The results of our own studies of haemostasis in premature infants are presented. Prothrombin levels, activated partial thrombin time, international normalized ratio, and brinogen were investigated. The level of proin ammatory interleukin 8 was also studied in both groups. Results and discussion. It has been shown that premature infants have a tendency toward hypocoagulation and increased levels of interleukin 8. This tendency increases in children born at an earlier term. Thus, the results obtained indicate that in the group of premature infants haemostasis parameters differ signi cantly as compared to the level of similar values in premature infants. Conclusion. The revealed changes re ect the reduced adaptive resource to birth stressand altered environmental factors. This suggests a high risk of haemorrhagic disorders in this group of children and requires the study of haemorrhagic disorder risk predictors.

Key words: premature infants, coagulogram, interleukin 8, hypocoagulation.

For reference: Vorontsova IA, Loskutova EV, Vakhitov KhM, Vakhitova LF, Valeyeva IKh. Elevated IL-8 levels as a predictor of hemorrhagic disorders in premature infants. The Bulletin of Contemporary Clinical Medicine. 2021; 14 (2): 16-20. DOI: 10.20969/VSKM.2021.14(2).16-20.

References

1. Kazantseva NV, Izranov VA, Shevtsova OA, Shotik YuV. Sovremennyye metody antenatal’noy diagnostiki sostoyaniya ploda i ikh znacheniye dlya prognozirovaniya posleduyushchego razvitiya rebenka [Modern methodsof antenatal diagnosis of the state of the fetus and their importance for predicting the subsequent developmentof the child]. Rosiyskiy vestnik perinatologii i pediatrii [Russian Bulletin of Perinatology and Pediatrics]. 2018; 63 (5): 13-19.

2. Loskutova EV, Vorontsova IA, Vakhitov KhM, et al. Sostoyaniye sistemy lipoperoksidatsii u nedonoshennykh novorozhdennykh, perenesshikh perinatal’nuyu gipoksiyu [The state of the lipoperoxidation system in premature infants who underwent perinatal hypoxia]. Rossiyskiy vestnik perinatologii i pediatrii [Russian Bulletin of Perinatology and Pediatrics]. 2018; 63 (5): 135-138.

3. Shilova NA, Kharlamova NV, Fisyuk YA, Chasha TV, et al. Chastota i iskhody retinopatii u glubokonedonoshennykh novorozhdennykh v usloviyakh okazaniya spetsializirovannoy meditsinskoy pomoshchi [The frequency andoutcomes of retinopathy in very premature infants in thecontext of specialized medical care]. Rosiyskiy vestnik perinatologii i pediatrii [Russian Bulletin of Perinatology and Pediatrics]. 2018; 63 (5): 51-54.

4. Ivanov DO, Petrenko YuV. Pokazateli sistemy gemostaza pri DVS sindrome razlichnogo geneza u novorozhdennykh detey [Indicators of the hemostatic system in DIC syndrome of various origins in newborn children]. Translyatsionnaya meditsina [Translational Medicine]. 2014; 1: 44-52.

5. Kuzmenko GN, Nazarov SB. Pokazateli plazmennogo gemostaza u detey, rozhdennykh na 35-36 nedele gestatsii [Plasma hemostasis indicators in children born at 35-36 weeks of gestation]. Rossiyskiy vestnik perinatologii i pediatrii [Russian Bulletin of Perinatology and Pediatrics]. 2015; 60 (1): 38-43.

6. Kozlova EL, Klimkovich NN. Osobennosti funktsionirovaniya sistemy gemostaza v ranniy neonatal’nyy period [Features of the functioning of the hemostasis system in the early neonatal period]. Problemy zdorov’ya i ekologii [Problems of health and ecology]. 2011; 4 (30): 13-19.

7. Bessonova GN, Buslaeva GN, Nikushkin EV, et al. Sostoyaniye gemostaza zdorovykh plodov [The state of hemostasis of healthy foetuses]. Voprosy prakticheskoy pediatrii [Questions of practical paediatrics]. 2008; 3 (1): 52-55.

8. Kuzmenko GN, Nazarov SB, Popova IG, et al. Funktsional’nyye osobennosti gemostaza donoshennykh i nedonoshennykh novorozhdennykh, po dannym tromboelastogra i [Functional features of hemostasis of full-term and premature infants, according to thromboelastography]. Klinicheskaya laboratornaya diagnostika [Clinical laboratory diagnostics]. 2013; 5: 14-17.

9. Lech-Maranda E, Bienvenu J, Broussais-Guillaumot F, Warzo-cha K, Michallet AS, Robak T, et al. Plasma TNF-alpha and IL-10 level-based prognostic model predicts outcome of patients with diffuse large B-Cell lymphoma in different risk groups de ned by the International Prognostic Index. Arch Immunol Ther Exp (Warsz). 2010; 58 (2): 131-41.

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  2. Vitkovsky YuA. Rol’ tsitokinov v regulyatsii sistemy gemostaza: avtoreferat dissertatsii na soiskaniye uchenoy stepeni doktora meditsinskikh nauk [The role of cytokines in the regulation of the hemostasis system; abstract of the thesis for the degree of Doctor of Medical Sciences]. Chita: Chitinskaya gosudarstvennaya meditsinskaya akademiya [Chita: Chita State Medical Academy]. 1997; 39 p.

  3. Tarabar O, Cikota-Aleksic B, Tukic L, Milanovic N, Aleksic A, Magic Z. Association of interleukin-10, tumor necrosis factor-a and transforming growth factor-P gene polymorphisms with the outcome of diffuse large B-cell lymphomas. Int J Clin Oncol. 2014; 19 (1): 186-92.

13. Levkovich MA, Plakhotya TG, Berdichevskaya EM, Tsaturyan LD. Osobennosti tsitokinovoy regulyatsii pri khronicheskoy platsentarnoy nedostatochnosti [Features of cytokine regulation in chronic placental insuf ciency]. Sovremennyye problemy nauki i obrazovaniya [Modern problems of science and education]. 2016; 4: https://www.elibrary.ru/download/elibrary_26532809_36770608.pdf

14. Nedoseykina MS. Provospalitel’nyye tsitokiny pri infektsionno-obuslovlennykh oslozhneniyakh beremennosti i vnutriutrobnom in tsirovanii [Pro-in ammatory cytokines in infectious complications of pregnancy and intrauterine infection]. Znaniye [Knowledge]. 2015; 12-2 (29): 105-110.

 

UDC 615.28:339.138(470.57)

DOI: 10.20969/VSKM.2021.14(2).21-25

PDF download MARKET RESEARCH ON PERSONAL PROTECTIVE EQUIPMENT: ANTISEPTICS

IBRAGIMOVA GUZEL YA., ORCID ID: 0000-0003-4066-9406; D. Pharm. Sci., the Head of the Department of management and economics of pharmacy with the course of medical and pharmaceutical commodity science of Bashkir State Medical University, Russia, 450008, Ufa, Lenin str., 3

IKSANOVA GALINA R., ORCID ID: 0000-0002-8693-3869; C. Med. Sci., associate professor of the Department of pharmacy at supplementary professional education institution of Bashkir State Medical University, Russia, 450008, Ufa, Lenin str., 3

MURATOLIEVA ANARBUU J., ORCID ID: 0000-0002-2709-5121; C. Med. Sci., the Head of the Department of pharmacognosy and chemistry of drugs of Kyrgyz Medical Academy named after I. K. Akhunbayev, Kyrgyz Republic, Bishkek, 720020, Akhunbayev str., 92

Abstract. Aim. The aim of the research was to conduct a marketing study of antiseptic agents used for personal protection for infectious diseases, including COVID-19 in the setting of one subject of the Russian Federation. Material and methods. Content analysis of normative-legal documentation describing antiseptic agents, Internet resources devoted to personal protective equipment (PPE), and web sites of pharmacy organizations was performed. Marketing analysis of the assortment of pharmacy organizations in the Republic of Bashkortostan was conducted. Results and discussion. Since 2010, according to Rospotrebnadzor FS, 4131 disinfectants have been registered, including 422 names of skin antiseptics. Since the beginning of 2020, 116 additional disinfectants have been registered. Safety and effectiveness of disinfectants is con rmed by chemical analysis, toxicity tests and microbiological tests. According to our sociological survey of residents of the Republic, 87,5% of respondents noted that during the COVID-19 pandemic they began to wash their hands and use hand sanitizers more often. Most respondents (82%) go to pharmacies for preventive and personal care products because they trust the quality of pharmacy products more. However, purchases are also being done on Internet sites, in shopping centers, in hardware stores, etc., with the price and availability of antiseptic agents more often being the main parameter in antiseptic selection. Conclusion. The conducted researchallowed us to determine the main properties of antiseptics, their characteristics, application features, as well as their market, which will allow consumers to choose the available means, focusing on the recommendations and rules.

Key words: classi cation, personal protective equipment, antiseptics, sanitizers, pharmacy organizations, marketing research.

For reference: Ibragimova GY, Iksanova GR, Muratalieva AJ. Marketing research on personal protective equipment: antiseptics. The Bulletin of Contemporary Clinical Medicine. 2021; 14 (2): 21-25. DOI: 10.20969/VSKM.2021.14(2).21-25.

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  6. Guinan M, McGuckin M, Ali Y. The effect of a comprehen-sive handwashing program on absenteeism in elementaryschools. Am J Infect Control. 2002; 30 (4): 217-20.

  7. Gancev ShH, Men’shikov KV. Onkologicheskayasluzhba v usloviyahpandemii COVID-19 (obzorliteratury) [Oncological Care During the Covid-19 Pandemic (Literature Review)]. Kreativnaya hirurgiya i onkologiya [Creative surgery and oncology]. 2020;10 (3): 233-240.

  8. Samorodov AV, Zolotuhin KN. Pro laktika COVID-19-associirovannogo narusheniya gemostaza u pacienta so stentirovannymi koronarnymi arteriyami; Klinicheskij sluchaj [Prevention of COVID-19-associated Haemostasis Failure in Patient with Stented Coronary Arteries: a Clinical Case]. Kreativnaya hirurgiya i onkologiya [Creative surgery and oncology]. 2020; 10 (2): 137-142.

  9. Samorodov AV, Zolotuhin KN, Zabolotskij DV, Aleksandrovich YuS, Bashirova LI. Osobennosti trombo-elastograficheskogo profilya pacientov s COVID-19 v usloviyah ORIT. [Speci c parameters of the thromboelastographic pro le of patients with COVID-19 in the intensive care unit]. Vestnik anesteziologii i reanimatologii [Messenger of anesthesiology and resuscitation]. 2020; 17 (6): 39-44.

  10. Ziganshin AM, Mudrov VA, Nasyrova SF, et al. Vozmozh-nosti distancionnogo obucheniya v period epidemiiCOVID-19 [Distance learning opportunities during the COVID-19 epidemic]. Kazanskij medicinskij zhurnal [Kazan medical journal]. 2020; 101 (6): 876-882.

  11. Predotvrashchayut li «razzhizhiteli» krovi (antikoagulyanty) obrazovanietrombov u lyudej, gospitalizirovannyh s COVID-19? [Prophylactic anticoagulants for people hospitalised with COVID-19]. Kazanskij medicinskij zhurnal [Kazan medical journal]. 2020; 101 (6): 957-958.

  12. O rekomendaciyah kak vybrat’ antiseptic protiv koronavirusa [About recommendations on how to choose an antiseptic against coronavirus]. Pis’mo Rospotrebnadzora ot 06 oktyabrya 2020 goda [Rospotrebnadzor letter dated 06/10/2020]. https://www.rospotrebnadzor.ru/about/info/ news/news_details.php?ELEMENT_ID=15569

  13. Rekomendovannye VOZ receptury antiseptikov dlya ruk: Rukovodstvo po organizacii proizvodstva na mestah [WHO-recommended formulations of hand sanitizers: Guidelines for the organization of production in the eld]. 2012; 9 p. https://www.who.int/gpsc/5may/tools/ guide_local_production_ru.pdf?ua=1

  14. Gosudarstvennyj reestr lekarstvennyh sredstv [State register of medicines]. http://grls.rosminzdrav.ru/

  15. Krivoshein YuS, Rud’ko AP. Sredstvo inaktivacii koronavirusov [Agent for inactivation of coronavirus]: 2234313 Rossiya: MPK7 A61K31/165, A61R31/14 /; 2003116391/15; zayavleno 04/06/2003. 2004; 23 (II): 4 p.

  16. O gosudarstvennoj registracii dezinficiruyushchih sredstv [About state registration of disinfectants]. Pis’mo Rospotrebnadzora ot 22 aprelya 2020 goda [Rospotrebnadzor letter dated April 22, 2020]. https:// www.rospotrebnadzor.ru/about/info/news/news_details. php?ELEMENT_ID=14290

 

UDC 616.31-053.2-02:159.944.4

DOI: 10.20969/VSKM.2021.14(2).26-31

PDF download EARLY AND LATE COMPLICATIONS OF PSYCHO-EMOTIONAL OVERLOAD IN PEDIATRIC DENTISTS

KAZAKOVA LARISA N., ORCID ID: 0000-0001-8060-1348; C. Med. Sci., associate professor of the Department of pediatric dentistry and orthodontics of Saratov State Medical University n. a. V.I. Razumovsky, Russia, 4100012, Saratov, B. Kazachya str., 112, tel. 8-905-321-06-11, e-mail: avkuligin@yandex.ru

DAVYDOVA NATALIYA V., ORCID: 0000-0001-6303-3975; assistant of professor of the Department of pediatric dentistry and orthodontics of Saratov State Medical University n. a. V.I. Razumovsky, Russia, 4100012, Saratov, B. Kazachya str., 112, tel. 8-903-386-30-12, e-mail: natdav13@yandex.ru

NARYZHNAYA ELENA V., ORCID: 0000-0001-7526-2804; assistant of professor of the Department of pediatric dentistry and orthodontics of Saratov State Medical University n. a. V.I. Razumovsky, Russia, 4100012, Saratov, B. Kazachya str., 112, tel. 8-905-384-40-03, e-mail: eturusova@bk.ru

TERESHCHUK OKSANA S., ORCID ID: 0000-0002-4917-797X; assistant of professor of the Department of emergency medicine, anesthesiology and resuscitation and simulation technologies in medicine of Saratov State Medical University n. a. V.I. Razumovsky, Russia, 4100012, Saratov, B. Kazachya str., 112, tel. 8-937-243-80-98, e-mail: kleo.ok@ yandex.ru

OLEYNIKOVA NATALIYA M., ORCID ID: 0000-0002-8062-0861; assistant of professor of the Department of pediatric dentistry and orthodontics of Saratov State Medical University n. a. V.I. Razumovsky, Russia, 4100012, Saratov, B. Kazachya str., 112, tel. 8-917-213-06-90, e-mail: olei-n@yandex.ru

SAYUTINA LARISA V., ORCID: 0000-0002-5982-5811; resident of the Department of pediatric dentistry and orthodontics of Saratov State Medical University n. a. V.I. Razumovsky, Russia, 4100012, Saratov, B. Kazachya str., 112, tel. 8-905-384-40-03, e-mail: larisayutina96@yandex.ru

Abstract. Clinical observations show that one of the risk factors for the onset and progression of dental disease is extreme exposure. Aim. The aim of the study was to reveal the nature of the in uence of extreme exposure on changes in saliva cortisol levels as well as on the development of pathological conditions of the oral cavity tissues. Material and methods. Electrochemiluminescence analysis of saliva, questionnaires in the study groups, and analysis of variance were performed. Results and discussion. The study determined an increased level of cortisol in saliva during theday; when its concentration should be minimal, it exceeded the indicators of the control group by 9,6 times. Against the background of high levels of cortisol in the oral cavity the existing pathological processes progressed, and the primary complaints typical for the beginning of in ammation of oral tissues appeared. Conclusion. Psycho-emotional stress in pediatric dentists increases salivary cortisol levels 9,6-fold. Prolonged maintenance of high levels of cortisol in saliva and high amplitude of frequent increases leads to persistent pathological conditions of oral tissues. Thus, monitoringthe condition of the sympathoadrenal system by controlling the qualitative composition of saliva can be recommendedas one of the options for early diagnosis of distress of various nature.

Key words: extreme exposure, stress, depression, oral cavity diseases, cortisol.

For reference: Kazakova LN, Davydova NV, Naryzhnaya EV, Tereshchuk OS, Oleynikova NM, Sayutina LV. Early and late complications of psycho-emotional overload in pediatric dentists. The Bulletin of Contemporary Clinical Medicine. 2021; 14 (2): 26-31. DOI: 10.20969/VSKM.2021.14(2).26-31.

References

  1. Bodneva SL, Puzin MN, Kiparisova ES. Kompleksnaya ocenka nespecificheskih faktorov riska pri generalizovannom parodontite [Complex assessment of nonspeci c risk factors in generalized periodontitis]. Rossijskij stomatologicheskij zhurnal [Russian dental journal]. 2003; 2: 29-35.

  2. Obulareddy Vishnu Teja, Chava Vijay Kumar, Nagarakanti Sreenivas. Association of stress, salivary cortisol, and chronic periodontitis: aclinico-biochemical study. Contemp Clin Dent. 2018; 9 (2): 299-304. DOI: 10.4103/ccd. ccd_289_18 PMCID: PMC6169263 PMID: 30294161.

  3. Boyce W Thomas, Besten Pamela Den, Stamperdahl Juliet, Zhan Ling, Jiang Yebin, Adler Nancy, Featherstone John. Social Inequalities in Childhood Dental Caries: The Convergent Roles of Stress, Bacteria and Disadvantage. Soc Sci Med. 2011; 71(9): 1644–1652. DOI: 10.1016/j. socscimed.2011.07.045 PMCID: PMC2954891 NIHMSID: NIHMS236525 PMID: 20870333.

  4. Owczarek Joanna Elżbieta, Lion Katarzyna Małgorzata, Małgorzata Radwan-Oczko. Manifestation of stress and anxiety in the stomatognathic system of undergraduate dentistry students. J Int Med Res. 2020; 48 (2): 0300060519889487. DOI: 10.1177/0300060519889487 PMCID: PMC7105728 PMID: 32046557.

  5. Yoshino Koichi, Suzuki Seitaro, Ishizuka Yoichi, TakayanagI Atsushi, Sugihara Naok, and Kamijyo Hideyuki. Relationship between job stress and subjective oral health symptoms in male nancial workers in Japan. Ind Health. 2017; 55 (2): 119–126. DOI: 10.2486/indhealth.2016-0120 PMCID: PMC5383409 PMID: 27840370.

  6. Tikhonova Svetlana, Booij Linda, D’Souza Violet, Crosara Karla TB, Siqueira Walter L, Emami Elham. Investigating the association between stress, saliva and dental caries: a scoping review. BMC Oral Health. 2018; 18: 41. DOI: 10.1186/s12903-018-0500-z PMCID: PMC5851323 PMID: 29534715.

  7. Kumar Jaya, Teoh Seong Lin, Das Srijit, Mahakknaukrauh Pasuk. Oxidative Stress in Oral Diseases: Understanding Its Relation with Other Systemic Diseases. Front Physiol. 2017; 8: 693. DOI: 10.3389/fphys.2017.00693 PMCID: PMC5603668 PMID: 28959211.

  8. Sardaro Nicola, Vella Fedora Bella, Incalza Maria Angela, Stasio Dario Di, Lucchese Alberta, Contaldo Maria, Laudadio Claudia, Petruzzi Massimo. Oxidative Stress and Oral Mucosal Diseases: An Overview. In Vivo. 2019; 33 (2): 289–296. DOI: 10.21873/invivo.11474 PMCID: PMC6506298 PMID: 30804105.

  9. Kang Y. Psychological stress -induced changes in salivary alpha-amylase and adrenergic activity. Nurs Health Sci. 2010; 12 (4): 477-484.

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  11. Shalenkova MA, Mihajlova ZD, Klemin VA, Klemin AM, Abanin AM, Klemina AV, Dolgov VV. Akusticheskij pokazatel’ slyuny pri stresse [Acoustic saliva indicator for stress]. Klinicheskaya laboratornaya diagnostika [Clinical Laboratory Diagnostics]. 2014; 3: 23-27.

  12. Tarasenko LM. Patogenez povrezhdeniya parodonta pri stresse [Pathogenesis of periodontal damage under stress]. Poltavskiy meditsinskiy stomatologicheskiy institut [Poltava Medical Stomatological Institute]. 1985; 41 p.

  13. Rabiei M, Kanjani MS, Leili EK, Kohanghadam S. The comparison between anxiety, level of salivary cortisol and SlgA in oral lichen planus. J Res Dent Sci. 2012; 9 (3): 125-31.

  14. Żukowski Piotr, Maciejczyk Mateusz, Waszkiel Danuta. Sources of free radicals and oxidative stress in the oral cavity. Review Arch Oral Biol. 2018; 92: 8-17. DOI: 10.1016/j.archoralbio.2018.04.018.

  15. Bikov IM, Korochanckaiy CP, Eremina TV, Chvostova TC, Storoshyk AP. Neinvazivnaya diagnostika khronicheskogo parodontita po pokazatelyam proantioksidantnogo statusa rotovoy zhidkosti [Non-invasive diagnosis of chronic periodontitis by indicators of the pro-antioxidant status of the oral uid]. Zhurnal fundamental’noy meditsiny i biologii [Journal of Fundamental Medicine and Biology]. 2015; 1: 37-39.

  16. Vasiliou A, Shankardass K, Nisenbaum R, Quiñonez C. Current stress and poor oral health. PhDBMC Oral Health. 2016; 16 (1): 88. DOI: 10.1186/s12903-016-0284-y PMCID: PMC5010733 PMID: 27590184.

  17. Džunková Mária, Gardlík Roman, Behuliak Michal, Janšáková Katarína, Jiménez Nuria, Vázquez-Castellanos Jorge F, Martí Jose Manuel, Giuseppe D’Auria, Bandara HN, Latorre Amparo, Celec Peter. Oxidative stress in the oral cavity is driven by individual-speci c bacterial communitie. NPJ Bio lms Microbiomes. 2018; 4: 29. DOI: 10.1038/s41522-018-0072-3 PMCID: PMC6258756 PMID: 30510769.

  18. Lindauer RJL, Carlier IVE, Gersons BPR. Neyrobiologiya posttravmaticheskogo stressovogo rasstroystva [Neurobiology of post-traumatic stress disorder]. Sotsial’naya i klinicheskaya psikhiatriya [Social and clinical psychiatry]. 2003; 13(1):146-150.

  19. Meshalkin EH, Disturbedkin EN, Sergievskiy VS, Suvorov AV. Tripsinemiya v reaktsii organizma na povrezhdeniya [Tripsinei in reactions to injury]. Novosibirsk: Nauka [Novosibirsk: the science]. 1982; 81 p.

 

UDC 616.853(479.24)

DOI: 10.20969/VSKM.2021.14(2).32-38

PDF download EPIDEMIOLOGICAL STUDY OF EPILEPSY IN THE SETTLEMENT OF MASHTAGA OF THE REPUBLIC OF AZERBAIJAN

MAGALOV SHARIF I., honored scientist, D. Med. Sci., professor, the Head of the Department of neurology, educational and medical building of Azerbaijan Medical University, Republic of Azerbaijan, АZ 1022, Baku, F. Gasimzade str., 14, tel. +9(9450)611-26-74

MELIKOVA SHAHLA YA., MD, assistant of professor of the Department of neurology, educational and medical building of Azerbaijan Medical University; Secretary General of the Azerbaijan Antiepileptic League and the Azerbaijan Branch of the World Federation of Neurology, Republic of Azerbaijan, АZ 1022, Baku, F. Gasimzade str., 14, e-mail: melikova.shahla@mail.ru

ASADOVA ULKER A., candidate for a degree of educational and medical building of Azerbaijan Medical University, member of Azerbaijan Antiepileptic League and the Azerbaijan branch of the World Federation of Neurology, the Head of the Red Crescent Society of the Sabunchi district of Baku, neurologist, United City Hospital No 7 in Mashtaga village, Republic of Azerbaijan, АZ 1039, Baku, Khanlar str., 43, tel. +9(9470)310-63-77, e-mail: asadli.u@mail.ru

Abstract. Aim. An epidemiological study of epilepsy in the Mashtaga settlement of Sabunchu district of Baku, Azerbaijan Republic, has been conducted. The incidence and prevalence of epilepsy in different age groups of patients with epilepsy were studied. Material and methods. Cohort pro- and retrospective study was performed at the United City Hospital (UCH) No 7 in Mashtagha settlement and at the Department of Neurology of the Educational and Medical Unit of the Azerbaijan Medical University. Epilepsy cases were identi ed by a continuous study of medical outpatient records from the outpatient department of United City Hospital No 7 and call registration data of local ambulance station No 14 for the period 2017–2019. Fisher’s criterion was used to estimate qualitative parameters. Correlation analysis was performed using Pearson rank correlation coef cient. The results are presented at a signi cance level of p<0,05. Results and discussion. The primary incidence of epilepsy in Mashtaga settlement for 2016–2019 ranged from 4,4/100 000 (2016) to 6,4 cases (2019) per 100 000 population and the overall incidence ranged from 413,3/100 000 (2016) to 421,1/100 000 population. The prevalence of epilepsy was 4,2 cases per 1 000 population. When examining the value of epilepsy prevalence by gender and age, it was signi cantly higher in males [(4,9/1000 (49,1190/000)] than in females [3,4/1000 (34,3070/000)]. The prevalence of epilepsy was highest in males in the early ages of 15–19 years (14,8/1000) and in females in the late ages of 40–49 years (5,7/1000). The incidence rate was gradually increasing from 0–4 years to 15–19 years and decreased by age 60–69 years. Epidemiological rates of epilepsy in Mashtaga village are in line with those in developed European countries, but lower than those in rural areas of Turkey and Pakistan. Conclusion. The outcomeof the research con rmed the importance of studying the epidemiology of epilepsy. The ndings helped to evaluate the effectiveness of the existing system of registration of patients with epilepsy in the region, the types of therapy used, as well as rehabilitation measures. The elimination of shortcomings in the local health care institution and the creation of an epileptology service will increase the effectiveness of epilepsy control efforts in the region.

Key words: epilepsy, epidemiology, prevalence, incidence.

For reference: Magalov ShI, Melikova ShYa, Asadova UA. Epidemiological study of epilepsy in the settlement of Mashtaga of the Republic of Azerbaijan. The Bulletin of Contemporary Clinical Medicine. 2021; 14 (2): 32-38.DOI: 10.20969/VSKM.2021.14(2).32-38.

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  5. Birjukbaeva GN, Nikolaeva TJa, Baisheva GM. Epidemiologicheskie aspekty izuchenija epilepsii [Epidemiological aspects of the study of epilepsy]. Dal’nevostochnyj medicinskij zhurnal [Far Eastern medical journal]. 2009; 3: 120-123.

  6. Geht AB, Guljaeva NV, Krylov VV. Epilepsija u bol’nyh insul’tom i cherepno-mozgovoj travmoj; Sovremennaja epileptologija [Epilepsy in patients with stroke and traumatic brain injury; Modern epileptology]. Moskva: APKIPPRO [Moscow: APKIPPRO]. 2011; 243-252.

  7. Gusev EI, Geht AB, Mil’chakova LE. Epidemiologija epilepsii v Rossijskoj Federacii. Sovremennaja epileptologija [Epidemiology of epilepsy in the Russian Federation. Modern epileptology]. Moskva: APKIPPRO [Moscow: APKIPPRO]. 2011; 77-85.

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  10. Magalov ShI, Hasanov NF, Azizova NX, Novruzov AN, Mustafayev ZB, Kazimov SA, Sultanov SSh, Hasanov EN, Aliyev G. The Prevalence of Epilepsy in the Nakhichevan Autonomous Republic of Azerbaijan. CNS & Neurological Disorders-Drug Targets. 2012; 2 (11): 102-109. DOI:10.2174/187152712800269768. PMID:2222932

  11. Magalov ShI, Halilova DM. Gendernye vzaimootno6enija bol’nyh eipilepsiej v Azerbajdzhane [Gender relationships of patients with epilepsy in Azerbaijan]. Mezhdunarodnyj nauchno-prakticheskij zhurnal Nevrologija i nejrohirurgijav Belorusii [International Scienti c and Practical Journal of Neurology and Neurosurgery in Belarus]. 2011; 3 (11): 136-140.

  12. Magalov ShI, Azizova NH, Alekberova SP, Melikova ShJa. Medikamentoznoe lechenie jepilepsii v gorode Gjandzhe: effektivnost’ i neadekvatnost’ [Drug treatment of epilepsy in the city of Ganja: effectiveness and inadequacy]. Azerbajdzhanskij Psihiatricheskij zhurnal [Azerbaijan Psychiatric Journal]. 2014; 1 (26): 84-94.

  13. Magalov ShI, Halilova DM, Asadova UA. Rol’ jetnicheskogo faktora v ocenke kachestva zhizni u bol’nyh epilepsiej v posjolke Mashtaga [The role of the ethnic factor in assess-ing the quality of life in patients with epilepsy in the village ofMashtaga]. Sovremennye dostizhenija azerbajdzhanskojmediciny [Modern achievements of Azerbaijani medicine]. 2020; 1: 237-244.

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UDC 616.98:578.834.1(470.341)

DOI: 10.20969/VSKM.2021.14(2).39-45

PDF download CORONAVIRUS PANDEMIC: EXPERIENCE OF THE FIRST WAVE IN THE NIZHNY NOVGOROD REGION

FEDOTOV VASILY D., ORCID ID: 0000-0003-4307-9321; C. Med. Sci., assistant of professor of the Department of internal medicine and general medical practice of Volga Research Medical University, Russia, 603005, Nizhny Novgorod, Minin i Pozjharsky sqr., 10/1, tel. +7(920)014-61-06, e-mail: basil11@yandex.ru

TULICHEV ALEXANDER A., C. Med. Sci., assistant of professor of the Department of introduction to internal medicine of Volga Research Medical University, Russia, 603005, Nizhny Novgorod, Minina i Pozjharsky sqr., 10/1, e-mail: mr.tulichev@mail.ru

FEDOTOVA OLGA O., internist of City outpatient clinic No 1, Russia, 603107, Nizhny Novgorod, Marshal Zhukov sqr., 5, e-mail: basil11@yandex.ru

DOBROTINA IRINA S., C. Med. Sci., associate professor of the Department of internal medicine and general medical practice of Volga Research Medical University, Russia, 603005, Nizhny Novgorod, Minin i Pozjharsky sqr., 10/1, e-mail: dobrotina@mail.ru

SHAKUROVA DINA N., chief physician of City Hospital No 3 (Geriatric Center in Nizhny Novgorod), Russia, 603155, Nizhny Novgorod, Verkhne-Volzhskaya emb., 21, e-mail: geront-nn@yandex.ru

Abstract. Aim. The aim of the study was to analyze the data from real clinical practice of diagnosis and treatment of a new coronavirus infection obtained during the rst wave of the virus in Nizhny Novgorod Region. Material and methods. We analyzed 4,250 records in the regional register of patients with con rmed coronavirus infection. For detailed analysis, 184 medical records of inpatients of medical institutions in Nizhny Novgorod and Nizhny Novgorod region with a diagnosis of con rmed coronavirus infection of different course and outcome were randomly selected. Of these, we used as analyzed groups the patients discharged with improvement (recovered) (n1 = 86) and those who died (n2 = 98). All patients underwent medical examination according to the current temporary clinical guidelines for the diagnosis and treatment of COVID-19 new coronavirus infection. Statistical processing was performed using Microsoft Of ce software package (Excel), USA and Statistica 10.0 (Statsoft, USA). Results and discussion. Our data allowed us to conclude that the prognosis is favorably in uenced by early hospitalization in the pulmonary stage of the disease, by early etiotropic and pathogenetic therapy, by the absence of concomitant disease, by adding systemic glucocorticosteroids on day 6–8 of hospitalization (which corresponds to the published data), and by tocilizumab. All patients received anticoagulants, but a more detailed analysis of the correlation of prescribed doses with prognosis is required to understand their impact on the outcome. Conclusion. Unfavorable prognostic factors were elderly age, cardiovascular and respiratory comorbidity, polymorbidity, late seeking medical care, 2 or more episodes of desaturation below 90% during treatment, increasing leukocytosis in the course of treatment, preservation of relative lymphopenia below 20% and monocytopenia in the course of treatment, preservation of high C-reactive protein, LDH and ferritin values despite the therapy.

Key words: coronavirus infection, pandemic, rst wave.

For reference: Fedotov VD, Tulichev AA, Fedotova OO, Dobrotina IS, Shakurova DN. Coronavirus Pandemic: experience of the rst wave in the Nizhny Novgorod region. The Bulletin of Contemporary Clinical Medicine. 2021; 14 (2): 39-45.DOI: 10.20969/VSKM.2021.14(2).39-45.

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REVIEWS

UDC 616.127-005.4-039.56-07:616.124.2-073(048.8)

DOI: 10.20969/VSKM.2021.14(2).46-51

PDF download COMPARISON OF LEFT VENTRICULAR CONTRACTILITY IN SILENT MYOCARDIAL ISCHEMIA BY ECHOCARDIOGRAPHY AND PERFUSION SCINTIGRAPHY

ABDRAKHMANOVA ALSU I., ORCID ID: 0000-0003-0769-3682; SCOPUS Author ID: 57192296744; C. Med. Sci., associate professor of the Department of clinical medicine fundamental basis of Institute of biology and fundamental medicine of Kazan Federal University, Russia, 420012, Kazan, Karl Marx str., 74; doctor of the Department of cardiology of Interregional clinical diagnostic center, Russia, 420089, Kazan, Karbyshev str., 12а, e-mail: alsuchaa@mail.ru

TSIBULKIN NIKOLAY A., ORCID ID: 0000-0002-1343-0478; C. Med. Sci., associate professor of the Department of cardiology, roentgen-endovascular and cardiovascular surgery of Kazan State Medical Academy – the branch of Russian Medical Academy of Postgraduate Education, Russia, 420012, Kazan, Butlerov str., 36

AMIROV NAIL B., ORCID ID: 0000-0003-0009-9103; SCOPUS Author ID: 7005357664; D. Med. Sci, professor of the Department of general medical practice of Kazan State Medical University, 420012, Russia, Kazan, Butlerov str., 49, e-mail: namirov@mail.ru

Abstract. Aim. The aim of the study was to compare the methods of echocardiography and single-photon emission computed tomography in assessing local left ventricular contractility in silent myocardial ischemia; to consider the possibility of comparing the data of echocardiography and single-photon emission computed tomography of myocardium in such patients. Material and methods. An analysis of the medical literature devoted to the problem of interest was performed. Results and discussion. Echocardiography or single-photon emission computed tomography is commonly used to assess regional left ventricular contractility. Single-photon emission computed tomography provides assessment of both contractile function and myocardial perfusion and viability. Single-photon emission computed tomography is highly reproducible, and more promising for objective assessment of left ventricular function. Single-photon emission computed tomography can be used to differentiate hypoperfused, but still viable myocardium, from irreversible myocardial brosis. The advantages of echocardiography are due to the short duration of the procedure, its low cost and affordability. However, the results of echocardiography are often subjective and depend on the physician’s experience. In addition, Doppler studies are limited by the scanning angle and are not always suitable for patients with a suboptimal ultrasound window. Thus, both echocardiography and single-photon emission computed tomography assess both integral and regional left ventricular contractility. Comparison of echocardiography and single-photon emission computed tomography results helps to understand the comparability of their ndings. The results of echocardiography agree with the quantitative assessment of single-photon emission computed tomography. The revealed differences in regional contractility estimations are related both to the methodology of echocardiography and to the speci c features of cardiac diseases. Conclusion. Studies used to assess regional left ventricular contractility, such as echocardiography and single-photon emission computed tomography, despite their positive and negative aspects, cannot fully replace each other, and the data obtained with their help are not always the same. It should be taken into account that neither instrumental method has absolute diagnostic accuracy.

Key words: silent myocardial ischemia, echocardiography, perfusion scintigraphy.

For reference: Abdrahmanova AI, Tsibulkin NA, Amirov NB. Comparison of left ventricular contractility in silent myo-cardial ischemia by echocardiography and perfusion scintigraphy. The Bulletin of Contemporary Clinical Medicine. 2021; 14 (2): 46-51. DOI: 10.20969/VSKM.2021.14(2).46-51.

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UDC 616.12-005.8-07:616.153.96-074(048.8)

DOI: 10.20969/VSKM.2021.14(2).52-55

PDF download PROGNOSTIC VALUE OF GROWTH DIFFERENTIATION FACTOR 15 (GDF-15) IN MYOCARDIAL INFARCTION

SABIRZYANOVA ALEXANDRA A., ORCID ID: 0000-0002-2130-0593; assistant of professor of the Department of cardiology of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, tel. +7-987-182-43-23, e-mail: S2101-Sash@yandex.ru

GALYVICH ALBERT S., ORCID ID: 0000-0002-4510-6197; D. Med. Sci., professor, the Head of the Department of cardiology of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, e-mail: agalyavich@mail.ru

Abstract. Determining the prognosis of a disease and risk strati cation are signi cant issues in practical medicine. Aim.The aim of the study was to estimate the prognostic value of growth differentiation factor 15 (GDF-15) in myocardial infarction according to the literature. Material and methods. A review and analysis of recent scienti c data on the prognostic value of growth differentiation factor 15 (GDF-15) were performed. Results and discussion. The searchfor new biomarkers that would provide additional information beyond the traditional clinical evaluation is ongoing. In cardiology, growth differentiation factor 15 (GDF-15) is considered to be such a new biomarker. GDF-15 is one of the transforming growth factor β (TGF-β) superfamily proteins, which is a marker of in ammation and oxidative stress. Serum GDF-15 levels have been found to be a powerful predictor of all-cause mortality in the general population, including a strong association with an increased risk of cancer of various causes and correlates with a history of diabetes mellitus and hypertension. The present review of the international literature presents current views on the prognostic value of GDF-15 in myocardial infarction. Increased levels of GDF-15 expression in cardiac tissue have been found in an experimental model of myocardial infarction and other cardiovascular diseases in mice. Several prospective studies have shown that the addition of GDF-15 as a component in multiple marker scales for cardiovascular event risk assessment can improve the patient reclassi cation. Conclusion. Thus, at present GDF-15 is considered by the scienti c community as a new biomarker of the risk of cardiovascular events.

Key words: growth differentiation factor 15, GDF-15, risk of cardiovascular events, risk strati cation scales.

For reference: Sabirzyanova AA, Galyavich AS. Prognostic value of growth differentiation factor 15 (GDF-15) in myocardial infarction. The Bulletin of Contemporary Clinical Medicine. 2021; 14 (2): 52-55.DOI: 10.20969/VSKM.2021.14(2).52-55.

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CLINICAL CASE

UDC 616.833.53-009.6

DOI: 10.20969/VSKM.2021.14(2).56-59

PDF download IDIOPATHIC RECURRENT LUMBOSACRAL PLEXOPATHY (clinical case)

SAFINA DIANA R., ORCID ID: 0000-0002-6466-4979; C. Med. Sci., assistant of professor of the Department of fundamental basis of clinical medicine of Institute of fundamental medicine and biology of Kazan Federal University, Russia, 420015, Kazan, K. Marx str., 74, e-mail: Safina_neuro@mail.ru

Abstract. Idiopathic lumbosacral plexopathy is a disease characterized by lesions of the lumbar and/or sacral plexus that are not related to trauma, mass effect, or diabetes mellitus. Several cases of recurrent lumbosacral plexopathy have been described in the literature, but we found no indication for a painless form of recurrence, which is the reason why this clinical case was described. Aim. The aim of the study was to use the example of clinical case of a patient with idiopathic recurrent lumbosacral plexopathy to analyze the course of the disease depending on management tactics. Material and methods. A 49-year-old female patient was admitted to the emergency neurology department with complaints of weakness, pain and sensory disturbances in the right leg. A neurological examination, including electromyography was performed. Results and discussion. According to electromyography, the changes indicated in favor of a lesion in the nerves of the right lumbosacral plexus. A neurological examination of the patient at the time of discharge and 9 months after showed a reduction in neurological symptoms. Four years after the patient’s rst admission to the emergency neurology department, weakness and sensory disturbances in the right leg increased again, but no pain syndrome was noted. The patient did not show a clear association between the recovery process at the rst exacerbation and medication intake, including methylprednisolone pullet therapy. Therefore, these groups of drugs were not prescribed at the second hospitalization, when spontaneous recovery was observed. Conclusion. At present, the cause of acute and recurrent lumbosacral radiculoplexopathy remains poorly understood; therefore, the treatment strategy in patients without a speci ed nature of nerve damage depends on the individual response to immunosuppressive and antiviral therapies. The waiting strategy with constant monitoring of neurological symptoms as illustrated by this clinical case allowed us to avoid prescribing ineffective drugs in this case as well as to con rm the theory of spontaneous recovery.

Key words: lumbosacral plexopathy, electromyography, recurrent form.

For reference: Safina DR. Idiopathic recurrent lumbosacral plexopathy (clinical case). The Bulletin of ContemporaryClinical Medicine. 2021; 14 (2): 56-59. DOI: 10.20969/VSKM.2021.14(2).56-59.

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