Download the whole Issue
ORIGINAL ARTICLES
Neuroimaging predictors of disability progression in multiple sclerosis. Kobys T.A. P.7
PRACTICAL EXPERIENCE
REVIEWS
CLINICAL CASE
THESIS RESEARCHES
___
NEUROIMAGING PREDICTORS OF DISABILITY PROGRESSION IN MULTIPLE SCLEROSIS
UDC 616.832-004.2 -036.1-073.756.8
DOI: 10.20969/VSKM.2016.9(4).7-14
KOBYS TATIANA A., C. Med. Sci., Head of Kyiv City Center of multiple sclerosis, Kyiv City Clinical Hospital № 4, candidate of a degree of the Department of neurology of O.O. Bogomolets National Medical University, Ukraine, Kyiv, 03110, Solomenska str.,17, tel. +38-067-287-31-65, e-mail: tkobys@ukr.net
Abstract. Aim. Identification of the main predictors of disability progression in multiple sclerosis (MS) patients depending on neuroimaging factors. Material and methods. A prospective ten-year study of 180 patients with MS. MRI was performed on GE unit Signa Excite HD 1.5T and was determined by the number of T2 lesions, including the ones with the size > 3 mm, T1 and Gd + lesions with subsequent determination of the level of cerebral metabolites. Results and discussion. Based on MRI monitoring we identified predictors of disability progression to EDSS > 3 points and ≥ 5 points. The prognostically significant signs were: the size of T2 lesions, their localization in cases of clinically isolated syndrome, the N-acetylaspartate to creatine ratio, and, with increasing duration of the disease, the number of T2 and T1 lesions. Conclusion. Prediction of the risk of achieving moderate to severe symptoms of MS disability in different periods from its beginning is possible on the basis of neuroimaging signs of disease activity.
Key words: multiple sclerosis, disability progression, lesions, cerebral metabolites.
For reference: Kobys TA. Neuroimaging predictors of disability progression in multiple sclerosis. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (4): 7—14.
REFERENCES
1. Scalfari A, Neuhaus A, Degenhardt A et al. The natural history of multiple sclerosis, a geographically based study. Relapses and long-term disability. Brain. 2010. Vol. 133 (7): 1914–1929.
2. Ziemsenn T, Tintore M. A New Era in Multiple Sclerosis: New Consideration for Therapeutic Approaches. Elsevier. 2010; 94 p.
3. Degenhardt A, Ramagopalan SV, Scalfari A, Ebers GC Clinical prognostic factors in multiple sclerosis: a natural history review. Nat Rev Neurol. 2009; 5 (12): 672–682.
4. Fisniku LK, Brex PA, Altmann D R et al. Disability and T2 MRI lesions: a 20-year follow-up of patients with relapse onset of multiple sclerosis. Brain. 2008; 131 (3): 808–817.
5. Ann Yeh E, Bianca Weinstock Guttman. Multiple sclerosis: predicting risk and delaying progression. Neurology. 2010; 9 (1): 7–9.
6. Kister I, Chamot E, Salter AR, Cutter GR, Bacon TE, Herbert J. Disability in multiple sclerosis: A reference for patients and clinicians. Neurology. 2013; 80 (11): 1018-1824.
7. Lerоy E, Yaouanq J, Le Page E et al. Evidence for a two-stage disability progression in multiple sclerosis. Brain. 2010; 133 (7): 1900–1913.
8. Tremlett H, Zhao Y, Rieckmann P, Hutchinson M. New perspectives in the natural history of multiple sclerosis. Neurology. 2010; 74 (24). 2004–2015.
9. Scalfari A, Neuhaus A, Daumer M, Deluca G, Muraro P, Ebers G. Early relapses, onset of progression, and late outcome in multiple sclerosis. JAMA Neurol. 2013; 70 (2): 214–222.
10. Sajja BR, Wolinsky JS, Narayana PA. Proton magnetic resonance spectroscopy in multiple sclerosis. Neuroimaging
Clin N Am. 2009; 19 (1): 45–58.
11. Tutuncu M. Tang J, Zeid NA et al. Onset of progressive phase is an age-dependent clinical milestone in multiple sclerosis. Mult Scler. 2013; 19 (2): 188–198.
12. Amato M, Zipoli V, Goretti B et al. Benign multiple sclerosis: cognitive, psychological and social aspects in a clinical. J Neurol. 2006; 253 (8): 1054–1059.
13. Correale J, Peirano I, Romano L. Benign multiple sclerosis: a new definition of this entity is needed. Mult Scler. 2012; 18 (2): 210–218.
14. Bar-Zohar D, Agosta F, Goldstaub D, Filippi M. Magnetic resonance imaging metrics and their correlation with clinical outcomes in multiple sclerosis: a review of the literature and future perspectives. Mult Scler. 2008; 14 (6): 719–727.
15. Lovblad K, Anzalone N, Doflier A et al. MR imaging in Multiple Sclerosis: review and recommendation for current practice. AJNR (Am J Neuroradiol). 2010; 31: 983–989.
16. Rovaris M, Rocca MA, Filippi M. Magnetic resonance-based techniques for the study and management
of multiple sclerosis. Br Med Bull. 2003; 65 (1): 133–144.
17. Sayao A, Devonshire LV, Tremlett H. Longitudinal follow-up of ‘benign’ multiple sclerosis at 20 years. Neurology. 2007; 68 (7): 496–500.
TOPICAL ISSUES OF CREATION OF AUTOMATED PRIMARY HEALTH CARE VOLUME CALCULATION SYSTEM IN TVER REGION
UDC 614.2(470.331):616-082:004.891
DOI: 10.20969/VSKM.2016.9(4).15-20
BERSENEVA EVGENIA A., D. Med. Sci., Head of the Department of higher and supplementary professional education of Semashko National Research Institute of Public Health, 117485, Moscow, Miclukho-Maclay str., 27/1/15, tel. +7-916-216-84-59, e-mail: eaberseneva@gmail.com
LALABEKOVA MARINA V., vice rector for public relations and educational work of Pirogov Russian National Research Medical University, 117997, Moscow, Ostrovityanov str., 1, e-mail: lalabekova_mv@rsmu.ru
CHERKASOV SERGEY N., D. Med. Sci., chief researcher of Semashko National Research Institute of Public Health, 117485, Moscow, Miclukho-Maclay str., 27/1/15, e-mail: meshkovdo@nriph.ru
MESHKOV DMITRY O., D. Med. Sci., Head of sector of coordination of scientific research of Semashko National Research Institute of Public Health, 117485, Moscow, Miclukho-Maclay str., 27/1/15, e-mail: meshkovdo@nriph.ru
Abstract. Topical issues of creation of the automated system of calculation of volume of primary health care in the Tver region are considered. Aim. Creation of the automated system of calculation of volume of primary health care in the Tver region, Russian Federation. Material and methods. Defining participants of the informational exchange, functional decomposition, creation of production rules. Results and discussion. The research prototype of the automated system of calculation of volumes of primary health care in the Tver region was developed. Calculation of the estimated volumes of medical care by means of this research prototype has coincided in 100% according to the results of the calculation executed earlier. Conclusion. On the basis of the results we recommend creation of an industrial prototype with introduction as the EGISZ module in different regions of the Russian Federation.
Key words: primary health-care, information technologies, expert systems.
For reference: Berseneva EA, Lalabekova MV, Cherkasov SN, Meshkov DO. Topical issues of creation of automated primary health care volumes calculation system in Tver region. The Bulletin of Contemporary Clinical Medicine. 2016;
REFERENCES
1. Habriev RU, Lindenbraten AL, Komarov JuM. Strategii ohrany zdorov’ja naselenija kak osnova social’noj politiki gosudarstva [Population Health strategies as basis of social policy of the state]. Problemy social’noj gigieny, zdravoohranenija i istorii mediciny [Problems of social hygiene, health care and history of medicine].2014; 3: 3–5.
2. Cherkasov SN, Kurnosikov MS, Sopova IL. Ispol’zovanie demograficheskogo analiza pri planirovanii ob#emov medicinskoj pomoshhi [Population analysis use when planning medical care amounts]. V sbornike: Jekologija i zdorov’e cheloveka na Severe sbornik nauchnyh trudov VI–go Kongressa s mezhdunarodnym uchastiem: pod redakciej PG Petrova [ In the collection: Ecology and health of the person in the north the collection of scientific works of the VI Congress with the international participation: under PG Petrov edition]. Kirov. 2016: 601–605.
3. Shhepin VO, Rastorgueva TI, Karpova OB. Sovremennye demograficheskie tendencii v Possijskoj Federacii [Current demographic trends in the Russian Federation]. Rossijskaja akademija medicinskih nauk: Bjulleten’ Nacional’nogo nauchno–issledovatel’skogo instituta obshhestvennogo zdorov’ja [Russian academy of medical sciences: Bulletin of National research institute of public health]. 2013; 2: 10–13.
4. Lalabekova MV, Cherkasov SN, Berseneva EA, Meshkov DO. Demograficheskie processy na territorii Tverskoj oblasti za period s 1994 po 2015 [Demographic processes in the territory of the Tver region from 1994 for 2015]. Rossijskaja akademija medicinskih nauk: Bjulleten’ Nacional’nogo nauchno–issledovatel’skogo instituta obshhestvennogo zdorov’ja [Russian academy of medical sciences: Bulletin of National research institute of public health]. 2015; 6: 87–100.
5. Shipova VM, Voroncov TN. Sovremennye problemy planirovanija medicinskoj pomoshhi [Modern problems of medical care planning]. Rossijskaja akademija medicinskih nauk: Bjulleten’ Nacional’nogo nauchno–issledovatel’skogo instituta obshhestvennogo zdorov’ja [Russian academy of medical sciences: Bulletin of National research institute of public health]. 2014; 1: 306–310.
6. Berseneva EA. Standarty medicinskoj pomoshhi kak chast’ informacionnogo obespechenija kompleksnoj informacionnoj sistemy lechebno–profilakticheskogo uchrezhdenija [Standards of medical care as part of information support of medical organization complex information system]. Jekonomika zdravoohranenija [Health care economy]. 2005; 9 (97): 21–27.
7. Berseneva EA. Informacionnye sistemy v upravlenii lechebno–profilakticheskim uchrezhdeniem [Information systems in medical organization management]. Vrach i informacionnye tehnologii [Doctor and information technologies]. 2006; 4: 75–76.
8. Berseneva EA, Sedov AA, Goluhov GN. Aktual’nye voprosy sozdanija avtomatizirovannoj sistemy leksicheskogo kontrolja medicinskih dokumentov [Topical issues of creation of the medical documents lexical control automated system]. Vrach i informacionnye tehnologii [Doctor and information technologies]. 2014; 1: 11–17.
9. Bruking A, Dzhons P, Koks F et al. Jekspertnye sistemy. Principy raboty i primery [Expert systems. Principles of work and examples]. Moskva: Radio i svjaz’ [Moscow: Radio and Communications]. 1987: 223 p.
10. Rambo D, Jakobson A, Buch G. UML: special’nyj spravochnik [UML: special reference book]. SPb: Piter, 2002: 656 p.
11. Kvatrani T. Vizual’noe modelirovanie s pomoshh’ju Rational Rose 2002 i UML [Visual modeling by means of Rational Rose 2002 and UML]. M: Izdatel’skij dom «Vil’jams» [Williams Publishing House], 2003: 192 p.
ASSESSMENT OF DRUG IMPACT ON HEART RATE TURBULENCE
UDC 616.12-008.318.4-085.22
DOI: 10.20969/VSKM.2016.9(4).21-27
GAREEVA DIANA F., postgraduate student of the Department of internal medicine of Bashkir State Medical University, Russia, Bashkortostan, 450000, Ufa, Lenin str., 3, tel. +7-919-140-71-49, e-mail: gareevadf@gmail.com
ZAGIDULLIN NAUFAL SH., D. Med. Sci., professor of the Department of internal medicine of Bashkir State Medical University, Russia, Bashkortostan, 450000, Ufa, Lenin str., 3, tel. (347)237-71-14, e-mail: znaufal@mail.ru
LAKMAN IRINA A., C. Tech. Sci., Ufa State Aviation Technical University, faculty of computer science and robotics, Russia, Bashkortostan, 450000, Ufa, K. Marx str., 12, tel. +7-927-965-56-55, e-mail: Lackmania@mail.ru
TULBAEV EDUARD L., D. Med. Sci., Head of the Department of cardiology in City Clinical Hospital № 21, Russia, Bashkortostan, 450000, Ufa, Lesnoy proezd, 3, tel. +7-246-53-42, e-mail: tulbaev@gmail.com
ZULKARNEEV RUSTEM KH., D. Med. Sci., professor of the Department of internal medicine of Bashkir State Medical University, Russia, Bashkortostan, 450000, Ufa, Lenin str., 3, tel. +7-347-246-53-97, e-mail: zrustem@mail.ru
ZAGIDULLIN SHAMIL Z., D. Med. Sci., professor, Head of the Department of internal medicine of Bashkir State Medical University, Russia, Bashkortostan, 450000, Ufa, Lenin str., 3, tel. (347)237-71-14, e-mail: zshamil@inbox.ru
Abstract. Heart rate turbulence recorded after ventricular premature beats is one of the most significant risk factors for sudden death after myocardial infarction. Propafenone is 1C antiarrhythmic drug used to treat ventricular premature beats in patients without structural heart disease. If-inhibitors is a new class of anti-anginal drugs, represented by Ivabradine. Effect of ivabradine and propafenone on heart rate turbulence hasn`t been studied. Aim. To study the effect of Propafenone and Ivabradine on the daily profile of heart rate turbulence in patients with ventricular premature ангиотенbeats. Material and methods. 28 outpatients were examined in an open controlled study — 25 in Ivabradine group and 5 in propafenone group. 3 hours after installing a 24-hour Holter monitor patients received Ivabradine in 7,5 mg or Propafenone 150 mg once. Results and discussion. The proportion of patients with pathological TO was 33,3% before the intake of Ivabradine, and later decreased to 22,2% (p=0,049). The median TS increased in 27,9%. The number of premature beats wasn`t significantly changed, but it tended to decrease. Propafenone improved TS, worsened TO and didn`t change the number of premature beats. However, a small number of patients doesn`t provide a full analysis of Propafenone`s impact. Conclusion. Positive effect of Ivabradine on heart rate turbulence was shown: TO improved (p=0,049) and stayed within the normal range after the action of Ivabradine. Propafenone`s significant effect on the parameters of heart rate turbulence was not revealed, but there was a tendency to decrease the frequency of ventricular arrhythmia, improving TS and worsening TO.
Key words: heart rate turbulence, ventricular arrhythmia, sudden death, ivabradine, propafenone.
For reference: Gareeva DF, Zagidullin NSh, Lakman IA, Tulbaev EL, Zulkarneev RH, Zagidullin ShZ. Assessment of drug impact on heart rate turbulence.The Bulletin of Contemporary Clinical Medicine. 2016; 9 (4): 21—27.
REFERENCES
1. Chuhnin EV, Amirov N.B. Variabel’nost’ serdechnogo ritma. Metod i klinicheskoe primenenie. [Heart rate variability. Method and clinical application]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Contemporary Clinical Medicine]. 2008; 1 (1): 72-78.
2. Bauer A, Malik M, Schmidt G et al. Heart rate turbulence: standards of measurement, physiological interpretation, and clinical use: International Society for Holter and Noninvasive Electrophysiology Consensus. J Am Coll Cardiol. 2008; 52: 1353-1365.
3. Schmidt G, Malik M, Barthel P et al. Heart-rate turbulence after ventricular premature beats as a predictor of mortality after acute myocardial infarction. Lancet. 1999; 353: 1390-1396.
4. Barthel P, Schneider R, Bauer A et al. Risk stratification after acute myocardial infarction by heart rate turbulence. Circulation. 2003; 108: 1221-1226.
5. Gareeva DF, Zagidullin BI, Nagaev IA et al. Turbulentnost’ serdechnogo ritma kak prediktor riska serdechno-sosudistoj smerti [Turbulence heart rate as a predictor of the risk of cardiovascular death]. Prakticheskaja medicina [Practical medicine]. 2012; 6: 39-43.
6. Bonnemeier H, Wiegand UKH, Friedlbinder J et al. Reflexcardiac activity in ischemia and reperfusion; Heart rate turbulence in patients undergoing direct percutaneous coronary intervention for acute myocardial infarction. Circulation. 2003; 108: 958-964.
7. Cygankiewicz I, Wranicz JK, Bolinska H et al. Influence of coronary artery bypass grafting on heart rate turbulence parameters. Am J Cardiol. 2004; 94: 186-189.
8. Cygankiewicz I. Heart rate turbulence. Prog Cardiovasc Dis. 2013; 56 (2): 160-171.
9. Lin LY, Hwang JJ, Lai LP et al. Restoration of heart rate turbulence by titrated beta-blocker therapy in patients with advanced congestive heart failure: positive correlation with enhanced vagal modulation of heart rate. J Cardiovasc Electrophysiol. 2004; 15: 752-756.
10. Marine JE, Watanabe MA, Smith TW et al. Effect of atropine on heart rate turbulence. Am J Cardiol. 2002; 89: 767-769.
11. Ozdemir M, Arslan U, Türkoğlu S et al. Losartan improves heart rate variability and heart rate turbulence in heart failure due to ischemic cardiomyopathy. J Card Fail. 2007; 13: 812-817.
12. Sredniawa B, Lenarczyk R, Musialik-Lydka A et al. Effects of cardiac resynchronization therapy on heart rate turbulence. Pacing Clin Electrophysiol. 2009; 32 (Suppl 1): 90-93.
13. Wustmann K, Kucera JP, Scheffers I et al. Effects of chronicbaroreceptor stimulation on the autonomic cardiovascular regulation in patients with drug-resistant arterial hypertension. Hypertension. 2009; 54: 530-536.
14. Zhong JH, Chen XP, Zeng CF et al. Effect of benazepril on heartrate turbulence in patients with dilated cardiomyopathy. Clin Exp Pharmacol Physiol. 2007; 34: 612-616.
15. Goldstein S, Brooks MM, Ledingham R et al. Association between ease of suppression of ventricular arrhythmia and survival. Circulation. 1995; 91: 79-83.
16. Oslopova JuV. Jeffektivnost’ propafenona v lechenii jekstrasistolii [Propafenone efficacy in treating arrhythmias]. Kazanskij medicinskij zhurnal [Kazan Medical Journal]. 2010; 91 (2): 152-158.
17. Fomina IG. Narushenija serdechnogo ritma [Cardiac arrhythmias]. Moskva [Moscow]: Russkij vrach [Russian doctor]. 2003; 350 p.
18. Monnet X, Ghalen B, Colen P et al. Effects of Heart Rate Reduction with Ivabradine on Exercise-Induced Myocardial Ischemia and Stunning. J Phar Exper Ther. 2001; 299: 1133-1139.
19. Bucchi A, Baruscotti M, Di Francesco D et al. Current-dependent Block of Sinoartrial Node If Channels by Ivabradine. J Gen Physiol. 2002; 120: 1-13.
20. Di Francesco D. Cardiac pacemaker If current and its inhibition by heart rate reducing agents. Curr Med Res Opin. 2005; 21: 1115-1122.
21. Zagidullin NSh. If-ingibitory novyj klass lekarstvennyh preparatov dlja lechenija stabil’noj stenokardii [If-inhibitors is a new class of drugs for the treatment of stable angina]. Consilium Medicum. 2006; 9: 23-31.
22. Zagidullin NSh, Travnikova EO, Zulkarneev RH et al. Vozmozhnosti primenenija IF-ingibitora ivabradina pri sinusovyh tahikardijah [Possibilities of application of IF-inhibitor ivabradine with sinus tachycardia]. Vrach [Doctor]. 2011; 7: 40-43.
23. Zagidullin NSh, Gareeva DF, Zagidullin BI et al. Sovremennye vozmozhnosti reguljacii ritma serdca pri ishemicheskoj bolezni serdca [Modern possibilities of regulation of the heart rhythm in patients with coronary heart disease]. Rossijskij kardiologicheskij zhurnal [Russian Cardiology Journal]. 2013; 5 (103): 61-
65.
24. Cvetnikova AA. Turbulentnost’ serdechnogo ritma: metodicheskie aspekty [Turbulence of cardiac rhythm: methodological aspects]. Sankt-Peterburg: INKART [St. Petersburg: INKART]. 2008; 32 p.
25. Colin P, Ghaleh B, Monnet X et al. Contributions of heart rate and contractility to myocardial oxygen balance during exercise. Am J. Physiol Heart Circ Physiol. 2003; 284 (2): 676-682.
26. Surovceva MV, Koziolova NA, Chernjavina AI. Dinamika variabel’nosti serdechnogo ritma serdca i zheludochkovoj jektopicheskoj aktivnosti u bol’nyh hronicheskoj serdechnoj nedostatochnost’ju ishemicheskoj jetiologii na fone terapii ibavradinom [The dynamics of heart rate variability and ventricular ectopic activity in patients with chronic heart failure of ischemic etiology in the background ibavradinom therapy]. Rossijskij kardiologicheskij zhurnal [Russian Cardiology Journal]. 2012; 6: 60-66.
27. Kurtoglu E, Balta S, Karakus Y. Ivabradine improves heart rate variability in patients with nonischemic dilated cardiomyopathy. Arq Bras Cardiol. 2014; 103 (4): 308-314.
28. Babunc IV, Miridzhanjan JeM, Mashaeh JuA. Azbuka analiza variabel’nosti serdechnogo ritma [The ABC analysis of heart rate variability]. Stavropol’: Printmaster [Stavropol: Print Master]. 2002; 112 p.
SPECIAL FEATURES OF REMODELING OF THE SUBCHONDRAL BONE IN OSTEOARTHRITIS WITH COMORBIDITY
UDC 616.728.3-007.248-06-07:616.718.5-073.75
DOI: 10.20969/VSKM.2016.9(4).27-32
KABALYK MAXIM A., C. Med. Sci., assistant of professor of the Department of internal medicine of Pacific State Medical University, Russia, 690002, Vladivostok, Ostryakov ave., 2, e-mail: maxi_maxim@mail.ru
Abstract. Aim. To characterize the features of remodeling of the subchondral bone (SCB) in patients with osteoarthritis (OA) with different levels of comorbid status using texture parameters. Material and methods. The study included 92 patients with stage I—IV OA of the knee according to Kellgren aged (66,1±10,5) years. Control group included 24 volunteers aged (29,6±5,96) years without clinical or radiological signs of OA. Patients with OA were divided into groups with «low», «moderate», «high» comorbidity and «metabolic phenotype» OA. Textural characteristics were evaluated by our own methodology. Results and discussion. The presence of radiographic evidence of OA directly correlated with the level of comorbidity. There is a statistically significant correlation between the age of patients with OA with comorbidities and the presence of cardiovascular events in the form of heart attacks and strokes. The volume of distribution of pixel values relative to the average value of grayscale tones (SDG) was significantly lower in patients with OA. The number of maximum peaks (EM) was significantly lower in patients with OA. Minimum peak on 3D-histogram (MinP) was significantly higher in OA and toning pixel row spacing in SCB was lower than in the control group. Conclusion. Our data indicate that SCB remodeling occurs in OA. Identified changes are more dependent on comorbid conditions. They give the prerequisites for pathogenetically justified classification of OA patients, depending on the presence of cardiovascular and metabolic diseases. Proposed methods of visual assessment are based on mathematical multidimensional analysis can be attributed to their potential diagnostic markers of OA on the basis of which discrimination of patients by the type of changes taking place in the SCB can be carried out. Proposed methods require morphological comparisons and clarification of the diagnostic value.
Key words: osteoarthritis, subchondral bone, remodeling, cardiovascular disease, texture analysis.
For reference: Kabalyk MA. Special features of remodeling of the subchondral bone in osteoarthritis with comorbidity. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (4): 27—32.
REFERENCES
1. Velasquez MT, Katz JD. Osteoarthritis: another component of metabolic syndrome? Metabolic Syndrome and Related Disorders. 2010; 8: 295-305.
2. Sellam J, Berenbaum F. Is osteoarthritis a metabolic disease? Joint Bone Spine. 2013; 80: 568-573.
3. Neogi T, Zhang Y. Epidemiology of osteoarthritis. Rheum. Rheumatic Diseases Clinics of North America. 2013; 39: 1-19.
4. Li H, George DM, Jaarsma RL, Mao X. Metabolic syndrome and components exacerbate osteoarthritis symptoms of pain, depression and reduced knee function. Annals of Translational Medicine. 2016; 4 (7): 133-136.
5. Grotle M, Hagen KB, Natvig B. Obesity and osteoarthritis in knee, hip and/or hand: an epidemiological study in the general population with 10 years follow-up. BMC Musculoskeletal Disorders. 2008; 9: 132-135.
6. Zhuo Q, Yang W, Chen J. Metabolic syndrome meets osteoarthritis. Nature Reviews Rheumatology. 2012; 8: 729-737.
7. Kabalyk MA. Spektral’nye i teksturnye harakteristiki subhondral’noj kosti pri gonartroze [Spectral and textural characteristics of the subchondral bone at gonarthritis]. Sovremennye problemy nauki i obrazovanija [Modern problems of science and education]. 2016; 2: 150.
8. Kabalyk M.A. Fraktal’nye i teksturnye harakteristiki subhondral’noj kosti pri osteoartroze [Fractal and textural characteristics of the subchondral bone at osteoarthritis]. Uspehi sovremennoj nauki [Successes of Modern Science]. 2016; 2 (3): 66-72.
9. Kabalyk MA, Dubikov AI, Petrikeeva TJu, Karabcov AA, Kuz’min II, Cherepovskij AV. Fenomen mikrokristallicheskogo stressa pri osteoartroze [The phenomenon of microcrystalline stress at osteoarthritis]. Tihookeanskij med. Zhurnal [Pacific Medical Journal]. 2014; 1: 70-74.
10. Ding M, Odgaard A, Hvid I. Changes in the three-dimensional microstructure of human tibial cancellous bone in early osteoarthritis. Journal of Bone and Joint Surgery. 2003; 85: 906–912.
11. Findlay DM. Vascular pathology and osteoarthritis. Rheumatology (Oxford). 2007; 46: 1763-1768.
12. Pottie P, Presle N, Terlain B. Obesity and osteoarthritis: more complex than predicted. Annals of the Rheumatic Diseases. 2006; 65: 1403-1405.
UDC [616.853+616.831-009.24]-053.2-082(571.55)
DOI: 10.20969/VSKM.2016.9(4).32-38
MARUEVA NATALIA A., C. Med. Sci., candidate of a degree of the Department of medical genetics and clinical neurophysiology of V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, neurologist-epidemiologist, assistant of professor of the Department of neurology, neurosurgery and medical genetics of Chita State Medical Academy, Russia, 672090, Chita, Gorky str. 39a, tel. 8-924-296-23-45, e-mail: maruevana@mail.ru
SHNAYDER NATALIA A., D. Med. Sci., professor, Head of the Department of medical genetics and clinical neurophysiology, Head of the Neurologic centre of epileptology, neurogenetics and brain research of University clinic of V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Russia, 660022, Krasnoyarsk, Partizan Zheleznyak str., 1, tel. 8(391) 221-24-49, e-mail: nataliashnayder@gmail.com
SHULMIN ANDREI V., D. Med. Sci., associate professor, Head of the Department of public health of V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Russia, 660022, Krasnoyarsk, Partizan Zheleznyak str., 1, e-mail: andreyshumn@gmail.com
SHIRSHOV YURI A., C. Med. Sci., professor, Head of the Department of neurology, neurosurgery and medical genetics of Chita State Medical Academy, Russia, 672090, Chita, Gorky str., 39a, tel. 8(3022) 35-43-24, e-mail: shirshov51@mail.ru
GOLTVANITSA GALINA A., C. Med. Sci., Head of the Centre antiepileptic in Transbaikal region, Regional children clinical hospital, Russia, 672000, Chita, Novobulvarnaya str., 20, tel. 8(3022) 32-57-84, e-mail: adm@kdkb75.ru
LEONTIEVA ELENA V., C. Med. Sci., neurologist-epidemiologist of the Centre antiepileptic in Transbaikal region, Regional children clinical hospital, Russia, 672000, Chita, Novobulvarnaya str., 20, tel. 8(3022) 32-57-84, e-mail: netmailLeo1371@mail.ru
KULINICH TATYANA S., deputy director on expertise of the Head office of medical and social assessment in Transbaikal region, Russia, 67203811, Chita, Kokhansky str., 11, tel. 8(3022) 28-38-88, е-mail: kultanja@mail.ru
Abstract. The aim is to evaluate medical and social factors contributing to organization of medical care for children with epilepsy in Transbaikal region. Material and methods. The data gathered from parents of 523 children with epilepsy and seizure syndromes (febrile seizures and isolated seizures) being treated in the Regional Antiepileptic Centre (RAEC) were analyzed. Results and discussion. The majority of parents (79,54%) of children with epilepsy and seizure syndromes apply for a medical care in due time; 5,74% do not apply in due time (after 1 year or more from the onset of the disease). 82,2% of the respondents are completely satisfied with the quality of medical care given by the epileptologists at the RAEC, 78,17% — by the hospital and emergency ambulance service, 73,3% — by the neurologists at the local out-patient departments. 93,43% of the parents strictly follow doctor’s recommendations concerning chemotherapy. 38,29% of the respondents assess medication availability as «good», 24,27% — «satisfying», 22,4% — «excellent». 22,56% of the respondents experience the lack of information on their children’s disease. 22,56% of the respondents experience the lack of information concerning the child’s disease. The main suggestions for improving care for children with epilepsy and convulsive syndromes were free medical treatment (5,16%). Conclusion. Medical care for children with epilepsy and convulsive syndromes both at specialized neurological level and at other stages of outpatient and inpatient care in the Transbaikal region was assessed by parents as satisfactory. In accordance with the wishes of the parents improved medical care should include the increase of parent awareness of the diagnosis, treatment and social care for epilepsy and seizures, development of an integrated multi-disciplinary system to improve the health and social care system.
Key words: epilepsy, convulsive disorders, children, teens, profile, parents, Transbaikal region.
For reference: Marueva NA, Shnayder NA, Shulmin AV, Shirshov YuA, Goltvanitsa GA, Leontieva EV, Kulinich TS. Evaluation of a specialized medical care of children with epilepsy and seizure syndromes in Transbaikal region. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (4): 32—38.
REFERENCES
1. International League Against Epilepsy (ILAE). Guidelines for epidemiologic studies on epilepsy; Commission on Epidemiology and Prognosis. Epilepsia.1993; 34: 592-596.
2. Meyer AC, Dua T, Boscardin WJ et al. Critical determinants of the epilepsy treatment gap: a cross-national analysis in resource-limited setting. Epilepsia. 2012; 53: 2178-2185.
3. Guseva EN, Konovalova AN, Geht AB ed. Nevrologija; Nacional’noe rukovodstvo; Kratkoe izdanie [Neurology; National Guidance; Brief Edition]. Moskva: Izdatel’stvo «GOJeTAR-Media» [Moscow: «GOETAR-Media» Publishing House]. 2014; 688 p.
4. Marueva NA, Shnajder NA, Shul’min AV et al. Jepidemiologija jepilepsii i sudorozhnyh sindromov v detskoj populjacii Zabajkal’skogo kraja [The epidemiology of epilepsy and seizures in the pediatric population of Trans-Baikal Region]. Zabajkal’skij medicinskij vestnik [Zabaykalsky Medical Journal]. 2015; 2: 119-128.
5. Broun T, Holms G. Jepilepsija: klinicheskoe rukovodstvo [Epilepsy: clinical manual]. M: Izdatel’stvo «Binom» [Moscow “Binom” Publishing House]. 2006; 288 p.
6. Karlov VA ed. Lechenie jepilepsii v knige “Jepilepsija u detej i vzroslyh zhenshhin i muzhchin” [Epilepsy treatment. In: Epilepsy in children and adult female and male patients]. Moskva: Izdatel’stvo «Medicina» [Moscow: “Medicine” Publishing House]. 2010; 631-659.
7. Hauser WA, Annegers JF, Kurland LT. Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984. Epilepsia. 1993; 34 (3): 453-468.
8. Shorvon S. Handbook of epilepsy treatment, 3rded. Singapore: Wiley-Blackwell. 2010; 75-146.
9. World Health Organization (WHO). Global burden and need for a coordinaited action at the country level to address its health, social and public knowledge implications. Resolution approved by the WHO Executive Board, http://apps.who.int/gb/ebwha/pdf_files/EB136/B136_R8-en.pdfAccessed February 12.2015.
10. Muhin KJu, Pylaeva OA, Gluhova LJu, Mironov MB, Bobylova MJu. Osnovnye principy lechenija jepilepsii; algoritm vybora antijepilepticheskih preparatov [Basic principles of epilepsy treatment; algorithm of anti-epileptic drugs selection]. Russkij zhurnal detskoj nevrologii [Russian Journal of Child Neurology]. 2014; 9 (4): 2–11.
11. Batysheva TT, Burd SG, Rubleva JuV, Badaljan OL. Reabilitacija pacientov s jepilepsiej [Rehabilitation of the patients with epilepsy]. SPb: Izdatel’stvo «Chelovek i ego zdorov’e» [St. Petersburg: “Human Health” Publishing House]. 2015; 45-46.
12. Zupans MN. Treatment of epilepsy in children and infants. Neurological Therapeutics: Principles and Practice. 2005; 65.
13. Panayiotopoulos CP. A clinical guide to epileptic syndromes and their treatment, 2nded. London: Springer. 2010; 45-49.
14. Belousova ED, Ermakov AJu, Dorofeeva MJu, Krapivkin AI, Malinovskaja ON, Harlamov DA. Kompleksnaja reabilitacija detej s medikamentozno-rezistentnymi invalidizirujushhimi formami jepilepsij: posobie dlja vrachej [Complex rehabilitation of children with drug resistant epilepsy: doctors’ reference book]. Moskva [Moscow]. 2004; 48 p.
15. Potapova ON. Dinamika detskoj invalidnosti v mediko-demograficheskom aspekte [Dynamics of childhood disability in the medical-demographic aspect]. Zdravoohranenie Rossijskoj Federacii [Health Care of the Russian Federation]. 2012; 1: 26-29.
UDC 616.329-089.168.1-06
DOI: 10.20969/VSKM.2016.9(4).39-44
NIZAMKHODZHAEV ZAYNIDDIN M., D. Med. Sci., professor, Head of the Department of esophagus and stomach surgery of acad. V. Vahidov RSCS, Uzbekistan, Tashkent, tel. +998-90-348-64-57, e-mail: docligay73@rambler.ru
LIGAY RUSLAN E., C. Med. Sci., senior research worker of the Department of esophagus and stomach surgery, of acad. V. Vahidov RSCS, Uzbekistan, Tashkent, tel. +998-90-348-64-57, e-mail: docligay73@rambler.ru
SHAGAZATOV DANIYAR B., С. Med. Sci., resident physician of acad. V. Vahidov RSCS, Uzbekistan, Tashkent, tel. +998-71-277-26-80
TSOY ALEKSEY O., junior research worker of the Department of esophagus and stomach surgery of acad. V. Vahidov RSCS, Uzbekistan, Tashkent, tel. +998-90-348-64-57, e-mail: alexey_tsoy@mail.ru
KHADZHIBAEV ZHAMSHID A., junior research worker of the Department of esophagus and stomach surgery of acad. V. Vahidov RSCS, Uzbekistan, Tashkent, tel. + 998-90-348-64-57
NIGMATULLIN ELNAR I., magistracy of Tashkent Medical Academy, Uzbekistan, Tashkent, tel. +998-90-372-24-77, e-mail: etoyaek@mail.ru
Abstract. The aim was to study character, frequency and causes of specific complications after esophagus extirpation. Material and methods. Department of esophagus and stomach surgery of acad. V. Vahidov RSCS has an experience in treatment of 234 patients who underwent extirpation of the esophagus between 1991 and 2015. All patients had undergone subtotal extirpation of the esophagus with one-stage esophagogastroplasty with formation of out-cavityneck anastomosis. Depending on the use of improved technical aspects of formation of the graft from the stomach, patients were divided into 2 groups. Control group (CG) consisted of 79 patients who underwent traditional method of stomach transplant forming in years 1991—2000. The main group (MG) consisted of 155 patients who had surgery in years 2001—2015 using patented improved method of stomach transplant forming. Results and discussion. We studied postoperative complications after esophageal extirpation in the MG. Comparative analysis of the frequency of specific complications in CG and MG was performed. Conclusion. All postoperative complications were combined into several groups: specific, bronchopulmonary, purulent-inflammatory, cardiovascular, thromboembolic, bleeding and others. Introduction of improved method of transplant forming reduced the incidence of specific complications.
Key words: esophagus, extirpation of esophagus, postoperative complications, specific complications, graft necrosis, insufficient esophageal anastomosis.
For reference: Nizamkhodjaev ZM, Ligay RE, Shagazatov DB, Tsoy AO, Khadjibaev JA, Nigmatullin EI. The features of specific postoperative complications after the extirpation of esophagus with one-stage gastroplasty. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (4): 39—44.
REFERENCES
1. Vereshhako RI. Pozdnie oslozhnenija subtotal’noj i total’noj jezofagoplastiki i metody ih ustranenija [Late complications of subtotal and total esophagoplasty and troubleshooting]. Klinicheskie issledovanija [Clinical researches]. 2010; 4: 21–125.
2. Davydov MI. Hirurgicheskoe lechenie bol’nyh rakom grudnogo otdela pishhevoda [Surgical treatment of patients with thoracic esophageal cancer]. Vestnik RONC imeni NN Blohina RAMN [Bulletin of the RCRC by NN Blokhin]. 2010; 3: 75–79.
3. Davydov MI, Stilidi IS. Rak pishhevoda [Cancer of the esophagus]. Moskva: Izdatel’stvo «Prakticheskaja Medicina» [Moscow: Publishing House “Practical Medicine”]. 2007: 392 p.
4. Krotov NF. Vybor metoda operativnogo vmeshatel’stva pri rake pishhevoda [The choice of method of surgery for esophagus cancer]. Kongress onkologov Uzbekistana [Congress of Oncologists of Uzbekistan]. Tashkent. 2015; 3: 7–8.
5. Miroshnikov BI. Jezofagoplastika pri «ushherbnom» zheludke ili ego otsutstvii [Esophagoplasty with «flawed» stomach or lack]. Vestnik hirurgii [Bulletin of surgery]. 2004; 2: 24–28.
6. Chernousov FA. Oslozhnenija stentirovanija u bol’nyh s dobrokachestvennymi i zlokachestvennymi zabolevanijami pishhevoda [Complications of stenting in patients with benign and malignant diseases of the esophagus]. Endo Hirurgija: XI sezd hirurgov Rossii [Endo Surgery: XI Congress of Russian surgeons]. Sbornik tezisov [Abstracts]. 2010; 15–18.
7. Kimura Y, Morita M, Saeki H. Minimally invasive total pharyng–laryngo–esophagectomy and reconstruction with gastric tube: report of three cases. Fukuoka Igaku Zasshi. 2013; 104 (11): 442–448.
8. Koyanagi K, Igaki H, Iwabu J, Ochiai H, Tachimori Y. Recurrent Laryngeal Nerve Paralysis after Esophagectomy: Respiratory Complications and Role of Nerve Reconstruction. Tohoku J Exp Med. 2015; 237 (1): 1–8.
9. Li B, Xiang J. Factors Affecting Hospital Mortality in Patients with Esophagogastric Anastomotic Leak: A Retrospective Study. World J Surg. 2015; 4: 176–182.
UDC 616.24-002.282(470.341-25)
DOI: 10.20969/VSKM.2016.9(4).44-51
POSTNIKOVA LARISA B., D. Med. Sci., associate professor, Head supernumerary pulmonologist of Nizhniy Novgorod region, Head of Municipal pulmonology advisory center of City Hospital № 28, Russia, 603035, Nizhny Novgorod, Chaadaev str., 7, e-mail: plbreаth@mail.ru
GUDIM ANDREY L., general practitioner of City Hospital № 28, Russia, 603035, Nizhny Novgorod, Chaadaev str., 7, e-mail: Andr6665@mail.ru
BOLDINA MARINA V., C. Med. Sci., assistant of professor of the Department of internal medicine of Nizhny Novgorod State Medical Academy, pulmonologist of Municipal pulmonology advisory center of City Hospital № 28, Russia, 603035, Nizhny Novgorod, Chaadaev str., 7, e-mail: mari.boldina@mail.ru
KOROTAEVA LYUDMILA A., pulmonologist of Municipal pulmonology advisory center of City Hospital № 28, Russia, 603035, Nizhny Novgorod, Chaadaev str., 7, e-mail: lyudmilakorotaeva@yandex.ru
ABANIN ALEXEY M., C. Med. Sci., associate professor of the Department of public health and health care of Nizhny Novgorod State Medical Academy, Russia, 603005, Nizhny Novgorod, Minin and Pozharsky square, 10/1, e-mail: abanin.am1@gmail.com
Abstract. Aim — to study clinical features of sarcoidosis, to evaluate the diagnostic and therapeutic resources of Nizhny Novgorod Pulmonary Consulting Centre (Centre). Material and methods. Hospital records of 121 patients with sarcoidosis followed-up in the Centre between 2007 and 2015 were analyzed retrospectively. Results and discussion. The number of patients with sarcoidosis increased more than 2,5 times since 2011. Women prevailed among the patients with sarcoidosis — 73,5%. The age of patients ranged from 16 to 71 years. The mean age was (42,4±14,2) years. Most women with sarcoidosis were older than 40 years (68,5%), men were younger — 16—40 years (78,2%) (p<0,001). Chest X-ray stage I observed in 18,2% patients, stage II — in most patients (77,7%), stage III had 3,3% and IV had 0,7% of patients. 46 (38%) patients had histological verification of sarcoidosis. Lofgren’s or Heerfordt’s syndromes were revealed in 3,3%. The most frequent symptoms were cough — 83,0%, fatigue — 46,6%, shortness of breath — 35,2%. The frequency of symptoms did not depend on sex of the patients or on the stage of sarcoidosis (p<0,05). Almost every fifth patient (19,1%) had extrapulmonary manifestations of sarcoidosis. 60,8% of the patients had skin lesions whereas enlarged peripheral lymph nodes were determined in 21,7% of the patients. 76,3% of the patients were receiving medications. 29% of the patients needed steroid therapy. Conclusion. The analysis of the prevalence of sarcoidosis, patient characteristics, clinical manifestations, diagnostic algorithm of sarcoidosis showed an increased attention to the problem of sarcoidosis in Nizhny Novgorod region and optimizing healthcare organization for this group of patients.
Key words: sarcoidosis, diagnosis, radiographic stage, treatment.
For reference: Postnikova LB, Gudim AL, Boldina MV, Korotaeva LA, Abanin AM. Clinical manifestations and the aspects of diagnostics and treatment of lung sarcoidosis in Nizhny Novgorod. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (4): 44—51.
REFERENCES
1. Chuchalin AG, Vizel AA, Ilkovich MM et al. Diagnostika i lechenie sarkoidoza: rezyume federalnyh soglasitelnyh klinicheskih rekomendaciy; chast 1: Klassifikaciya, etiopatogenez, klinika [Diagnosis and treatment of sarcoidosis: a summary of federal consensus clinical guidelines; Part 1: Classification, etiopathogenesis, clinic]. Vestnik sovremennoy klinicheskoy mediciny [The Bulletin of Contemporary Clinical]. 2014; 7 (4): 62-70.
2. Chuchalin AG, Vizel AA, Ilkovich MM et al. Diagnostika i lechenie sarkoidoza: rezyume federalnyh soglasitelnyh klinicheskih rekomendaciy; chast 2: Diagnostika, lechenie, prognoz [Diagnosis and treatment of sarcoidosis: a summary of federal consensus clinical guidelines; Part 2: Diagnosis, treatment, prognosis]. Vestnik sovremennoy klinicheskoy mediciny [The Bulletin of Contemporary Clinical Medicine]. 2014; 7 (4): 62-70.
3. Thomeer М, Demedts M, Wuyts W. Epidemiology of sarcoidosis. European Respiratory Monograph. 2005; 32: 23–32.
4. Vizel’ IJu, Vizel’ AA. Harakteristika registra bol’nyh sarkoidozom v Respublike Tatarstan [Characteristics of patients with sarcoidosis register in the Republic of Tatarstan].Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Contemporary Clinical Medicine]. 2015; 8 (5): 18-26.
5. Baranova OP, Refickaja NV et al. Jepidemiologija sarkoidoza organov dyhanija v Sankt-Peterburge (1998-2008) [Epidemiology of a sarkoidoz of respiratory organs in St. Petersburg (1998-2008)]. Sbornik trudov kongressa: XIX Nacional’nyj congress po boleznjam organov dyhanija [Collection of works of the congress: the XIX National congress by diseases of respiratory organs]. M. 2009; 216-217.
6. Mezhebovskij AV. Projavlenija sarkoidoza u gorodskogo i sel’skogo naselenija: dis kand med nauk [Manifestations of sarcoidosis in the urban and rural population: thesis of the candidate of medical sciences]. M. 2011; 101 p.
7. Petrov DV, Ovsjannikov NV, Mazhbich SM, Kochetov AM. Zabolevaemost’ I vozmozhnosti dispansernogo nabljudenija bol’nyh sarkoidozom v Omske. [Sickness rate and dispensary examination potential of sarcoidosis in Omsk]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Contemporary Clinical Medicine]. 2010; 3 (4): 29-32.
8. Lenshin AV, Grebennik AG, Suslova JuV, Karakulova OA. Vnutrigrudnoj sarkoidoz. Optimizacija ambulatorno-poliklinicheskoj luchevoj diagnostiki [Intrathoracic sarcoidosis. Optimization of out-patient and policlinic roentgen diagnostics]. Zdorov’e; Medicinskaja jekologija; Nauka [Health; Medical Ecology; The science]. 2009; 4-5: 105-108.
9. Robert P, Baughman RP, Grutters JC. New treatment strategies for pulmonary sarcoidosis: antimetabolites, biological drugs, and other treatment approaches. Lancet. 2015; 3 (10): 813-822.
10. Petrov DV, Ovsjannikov NV, Kononenko AJu, P’jannikova NG, Kapust’jan OV et al. Rezul’taty vnedrenija «Porjadka okazanija medicinskoj pomoshhi bol’nym sarkoidozom» v gorode Omske [Result of the introduction of «Order of medical care of sarcoidosis patients» in Omsk city].Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Contemporary Clinical Medicine]. 2013; 6 (2): 42-46.
11. Valeyre D, Prasse A, Nunes H, Uzunhan Y, Brillet P et al. Sarcoidosis. Lancet. 2013. Published online October 1; 1 — 13. http://dx.doi.org/10.1016/S0140-6736(13)60680-7
12. Vizel’ IJu, Vizel’ AA. Azbuka sarkoidoza; Beseda chetvertaja: Sarkoidoz: chto i kak my lechim [The ABCs of sarcoidosis; The fourth talk; Sarcoidosis: what and how we treat]. Atmosfera; Pul’monologija I allergologija [Atmosphere; Pulmonology and Allergology]. 2013; 3: 63- 65.
UDC 343.828(470.41)
DOI: 10.20969/VSKM.2016.9(4).51-56
TIMERZYANOV MARAT I., C. Med. Sci., associate professor of the Department of epidemiology of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, e-mail: Marat.Timerzanov@tatar.ru
GALIULLIN AFGAT N., D. Med. Sci., professor of the Department of management in health care of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, e-mail: kybm@mail.ru
VALIYEV FASIL V., physician of the Department of Medical Station of penal correction system of Russia in the Republic
of Tatarstan, Russia, 420111, Kazan, Kremlevskaya str., 12/1
Abstract. Aim — to study the incidence of convicts engaged in carpentry, plastering and painting works in the colonies of the Federal Penitentiary Service in the Republic of Tatarstan. Material and methods. Incidence analysis was conducted according to in-depth medical examination results of 708 convicts, depending on age, work experience, taking into account the working conditions, the characteristics of the labor process and the environment. We used hygienic and statistical methods. Results and discussion. Persons sentenced to imprisonment employed in construction and repair works have been exposed to wood dust, body, physical, dynamic load, noise from the saws, the specification of which is greater than 1,8 times. It was found that the highest incidence rates among prisoners were identified by arterial hypertension (46,6%), chronic tonsillitis (20,3%), chronic rhinitis and pharyngitis (20,9%) and chronic bronchitis (17,2%). Prevalence of hypertension increased from 15,7 to 36,6% in convicts employed in manufacturing at the experience of work from 1 to 20 years whereas chronic bronchitis incidence rose from 2,0 to 13,4%. Conclusion. The obtained data on incidence of convicts engaged in carpentry and painting works in penal colonies of the Republic of Tatarstan serves as the basis for development of measures to protect their health.
Key words: the profound routine medical examinations, incidence condemned to imprisonment, weight of labor process, repair construction works.
For reference: Timerzyanov MI, Galiullin AN, Valiyev FV. Analysis of morbidity of people sentenced to imprisonment in penal colony in Tatarstan, engaged in joinery, plastering and painting work, according to a thorough medical examination. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (4): 51—56.
REFERENCES
1. Borodulin VG. Ob itogah raboty v 2000 godu po organizacii medicinskogo obespechenija lic, soderzhashhihsja v uchrezhdenijah ugolovno–ispolnitel’noj sistemy Minjusta Rossii; Medicina v penitenciarnoj sisteme Rossii [On the results of work in 2000 on the organization of medical provision of persons held in institutions of the penal system of the Ministry of Justice of Russia; Medicine in the Russian penitentiary system]. Moskva: Prava cheloveka [Moscow: Human Rights]. 2001; 55–82.
2. Ermolaeva TV. Mediko–organizacionnye aspekty sovershenstvovanija medicinskogo obespechenija osuzhdennyh v ispravitel’nyh kolonijah strogogo rezhima: avtoreferat dissertacii kandidata medicinskih nauk [Medical and organizational aspects of perfection of medical maintenance of convicts in a penal colony: dissertation of the candidate of medical sciences]. Rjazan’.2012; 18 p.
3. Medik VA. Zabolevaemost’ naselenija: istorija, sovremennoe sostojanie i metodologija izuchenija [Morbidity: the history, current status and methodology of the study]. Moskva: Medicina [Moscow: Medicine]. 2003; 508 p.
4. Novikova VS ed. Sanitarno–gigienicheskie i social’no–bytovye aspekty soderzhanija VICh–inficirovannyh zhenshhin v mestah lishenija svobody: fiziologicheskaja ocenka uslovij voennoj sluzhby zhenshhin v vooruzhennyh silah RF [Sanitation and welfare aspects of HIV–positive women in prison: physiological assessment of the conditions of military service of women in the armed forces of the Russian Federation]. SPb: VmedA [St Petersburg: MMA]. 1999; 82–83.
5. Sannikov AL. Zdorov’e i social’naja zashhishhennost’ osuzhdennyh [Health and social protection of convicts]. Rossijskij medicinskij zhurnal [Russian Medical Journal].1998; 5: 10–12.
6. Statisticheskie materialy MJu RF GUIN [Statistical materials MDPE MJ RF]. Sostojanie zdorov’ja kontingentov, soderzhashhihsja v uchrezhdenijah ugolovno–ispolnitel’noj sistemy Rossijskoj Federacii v 2002 godu [Status contingents health contained in the institutions of the penal system of the Russian Federation in 2002]. Moskva: Medicinskoe upravlenie [Moscow: Medical Management]. 2003; 107 p.
UDC 616.24-036.12:616.12-008.331.1
DOI: 10.20969/VSKM.2016.9(4).56-65
SHPAGIN ILIA S., C. Med. Sci., assistant of professor of the Department of internal medicine and hematology of Novosibirsk State Medical University, Russia, 630084, Novosibirsk, Polzunov str., 21, tel. +7(383) 279-99-45, e-mail: mkb-2@yandex.ru
KOTOVA OLGA S., C. Med. Sci., associate professor of the Department of internal medicine and medical rehabilitation of Novosibirsk State Medical University, Russia, 630084, Novosibirsk, Polzunov str., 21, tel. +7(383) 279-99-45, e-mail: ok526@yandex.ru
POSPELOVA TATYANA I., D. Med. Sci., professor, pro-rector for scientific work, Head of the Department of internal medicine and hematology of Novosibirsk State Medical University, Russia, 630084, Novosibirsk, Polzunov str., 21, tel. +7(383) 279-99-45, e-mail: mkb-2@yandex.ru
GERASIMENKO OKSANA N., D. Med. Sci., professor of the Department of internal medicine and medical rehabilitation of Novosibirsk State Medical University, Russia, 630084, Novosibirsk, Polzunov str., 21, tel. +7(383) 279-99-45, e-mail: mkb-2@yandex.ru
SHPAGINA LUBOV A., D. Med. Sci., professor, Head of the Department of internal medicine and medical rehabilitation of Novosibirsk State Medical University, Russia, 630084, Novosibirsk, Polzunov str., 21, tel. +7(383) 279-99-45, e-mail: mkb-2@yandex.ru
ERMAKOVA MARGARITA A., D. Med. Sci., assistant of professor of the Department of internal medicine and medical rehabilitation of Novosibirsk State Medical University, Russia, 630084, Novosibirsk, Polzunov str., 21, tel. +7(383) 279-99-45, e-mail: mkb-2@yandex.ru
Abstract. Aim. To investigate chronic obstructive pulmonary disease (COPD) comorbid with arterial hypertension as a phenotype and to assess the association of polymorphisms M235T of the angiotensinogen gene, A1166C of the angiotensin II type 1 receptor gene and I/D (insertion/deletion) of the ACE gene with COPD and arterial hypertension comorbidity development. Material and methods. It was a single center prospective observational study. A total of 403 patients were included in four strata: COPD with arterial hypertension, COPD without arterial hypertension, arterial hypertension without COPD and healthy controls. The strata were comparable in the means of age, sex and number of smokers. Duration of the study was 10 (4,5—12,5) years. COPD strata were compared by the signs of disease. K-means clustering was performed for each stratum. Genetic risk of COPD and arterial hypertension comorbidity was assessed by logistic regression. Data is present as median and quartiles. Results and discussion. COPD and arterial hypertension were characterized by higher dyspnea severity, pulmonary hypertension (PH) of moderate severity [mean pulmonary artery pressure (mPAP) was 38 (34—52) mmHg], endothelial dysfunction and high angiotensin II serum level whereas severity of airflow limitation and lung hyperinflation were the same. Cluster analysis revealed a subgroup in COPD and arterial hypertension stratum characterized by low exacerbation rate, higher FEV1 and severe dyspnea, severe PH [mPAP 54 (48—65) mmHg] and highest angiotensin II level. COPD comorbid with arterial hypertension and its subgroup was associated with all assessed polymorphisms. Conclusion. COPD comorbid with arterial hypertension can be considered a distinct phenotype with genetic susceptibility. Hypothetically, renin-angiotensin-aldosterone system plays an important role in pathogenesis of this phenotype.
Key words: chronic obstructive pulmonary disease, arterial hypertension, phenotype, pulmonary hypertension.
For reference: Shpagin IS, Kotova OS, Pospelova TI, Gerasimenko ON, Shpagina LA, Ermakova MA. Chronic obstructive pulmonary disease comorbid with arterial hypertension — clinical, functional, molecular and genetic features. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (4): 56—65.
REFERENCES
1. Global Burden of Disease: Generating Evidence, Guiding Policy. — URL: http://www.healthmetricsandevaluation.org/gbd/publications/policy—report/global—burden—disease—generating—evidence—guiding—policyChuchalin AG, Avdeev SN, Ajsanov ZR et al. Rossijskoe respiratornoe obshhestvo: Federal’nye klinicheskie rekomendacii po diagnostike i lecheniju hronicheskoj obstruktivnoj bolezni legkih [Russian Respiratory Society: Federal clinical guidelines on diagnostic and treatement of Chronic Obstructive Pulmonary Disease]. Pul’monologija [Pulmonology]. 2014; 3: 15–36.
3. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease (Updated 2016). URL: http://www.goldcopd.com.
4. Han MK, Agusti A, Calverley PM et al. Chronic obstructive pulmonary disease phenotypes: the future of COPD. Am J Resp Crit Care Med. 2010; 182: 598–604.
5. Fabbri LM, Luppi F, Beghé B, Rabe KF. Complex chronic comorbidities of COPD. Eur Respir J. 2008; 31(1): 204–212.
6. García—Olmos L, Alberquilla A, Ayala V, et al. Comorbidity in patients with chronic obstructive pulmonary disease in family practice: a cross sectional study. BMC Fam Pract. 2013; 14: 11.
7. Chazova IE, Chuchalin AG, Zykov KA et al. Diagnostika i lechenie pacientov s arterial’noj gipertoniej i hronicheskoj obstruktivnoj bolezn’ju legkih (Rekomendacii Rossijskogo medicinskogo obshhestva po arterial’noj gipertonii i Rossijskogo respiratornogo obshhestva) [The diagnosis and treatment of patients with arterial hypertension and chronic obstructive inflammatory pulmonary diseases (Guidelines of the Russian Medical Society on Arterial Hypertension and the Russian Respiratory Society)]. Sistemnye Gipertenzii [System Hypertension]. 2013; 10: 5–34.
8. Miller J, Edwards LD, Agustí A et al. Comorbidity, systemic inflammation and outcomes in the ECLIPSE cohort. Respir Med. 2013; 107: 1376–1384.
9. Shrikrishna D, Astin R, Kemp PR, Hopkinson NS. Renin—angiotensin system blockade: a novel therapeutic approach in chronic obstructive pulmonary disease. Clin Sci (Lond). 2012; 123: 487–498.
10. Berdnikova NG, Bujkin SV, Bukreeva EB. Genetika bronholegochnyh zabolevanij [Genetic of bronchopulmonary diseases] M: Atmosfera. 2010: 160p.
11. Ehret GB, Munroe PB, Rice KM et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011; 478: 103–109.
12. Mancia G, Fagard R, Narkiewicz K et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension. The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Journal of Hypertension. 2013; 31: 1281–1357.
13. Miller MR, Hankinson J, Brusasco V et al. ATS/ERS Task Force. Standardisation of spirometry. Eur Respir J. 2005; 26: 319–338.
14. Blanco I, Piccari L, Barberà JA. Pulmonary vasculature in COPD: The silent component Respirology. 2016; URL: http://onlinelibrary.wiley.com/doi/10.1111/resp.12772/pdf
15. Martynjuk TV, Belevskaja AA, Dadacheva ZH et al. Vozmozhnosti jehokardiografii v diagnostike legochnoj gipertenzii i ocenke remodelirovanija serdca [The Role of Echocardiography in Diagnosis of Pulmonary Hypertension and Assessment of Heart Remodeling]. Lechebnoe delo [Internal medicine]. 2015; 1: 111–121.
16. Chaouat A, Naeije R, Weitzenblum E. Pulmonary hypertension in COPD. Eur Respir J. 2008; 32: 1371–1385.
17. Sethi AA, Nordestgaard BG, Gronholdt ML, Steffensen R et al. Angiotensinogen single nucleotide polymorphisms, elevated blood pressure, and risk of cardiovascular disease. Hypertension. 2003; 41: 1202–1211.
18. Baudin B. Polymorphism in angiotensin II receptor genes and hypertension. Exp Physiol. 2005; 90: 277–282.
19. Busquets X, MacFarlane NG, Heine—Suner D et al. Angiotensin—converting—enzyme gene polymorphisms, smoking and chronic obstructive pulmonary disease. Int J Chronic Obstruct Pulm Dis. 2007; 2: 329–334.
20. Cosenso—Martin LN, Vaz—de—Melo RO, Pereira LR et al. Angiotensin—converting enzyme insertion/deletion polymorphism, 24—h blood pressure profile and left ventricular hypertrophy in hypertensive individuals: a cross—sectional study. Eur J Med Res. 2015; 20:
74.
TREATMENT OF ARTHROSIS OF THE TEMPOROMANDIBULAR JOINT
UDC 616.724-007.248-08-039.73
DOI: 10.20969/VSKM.2016.9(4).66-71
TARASOV IVAN V., postgraduate student of the Department of maxillofacial surgery and surgical dentistry of Moscow Regional Research Clinical Institute, Russia, 129110, Moscow, Shchepkin str., 61/2, tel. +7-926-819-58-06, e-mail: martini-87@list.ru
NIKITIN ALEXANDER A., D. Med. Sci., professor, Head of the Department of maxillofacial surgery, Head of the Department of maxillofacial surgery and surgical dentistry of Moscow Regional Research Clinical Institute, Russia, 129110, Moscow, Shchepkin str, 61/2
PEROVA NADEZHDA V., D. Biol. Sci., deputy director of the Institute of Biomedical Research and Technology, Russia, 123557, Moscow, Bolshoy Tishinskiy lane, 43/2, bld. 2, tel. +7-926-607-66-25, e-mail: 89266076625@mail.ru
CHUKUMOV RINAT M., C. Med. Sci., researcher of the Department of maxillofacial surgery and surgical dentistry of Moscow Regional Research Clinical Institute, Russia, 129110, Moscow, Shchepkin str., 61/2
GUSAROV DANIIL E., postgraduate student of the Department of maxillofacial surgery and surgical dentistry of Moscow Regional Research Clinical Institute, Russia, 129110, Moscow, Shchepkin str., 61/2
Abstract. Temporomandibular joint (TMJ) is one of the frequently used joints of the human body. The most common TMJ pathologies are degenerative-dystrophic diseases, such as osteoarthritis, leading to restriction of activity, and often to disability and reduced quality of life. Aim. To assess the effectiveness of conservative treatment of osteoarthritis ofthe temporomandibular joint with heterogeneous biopolymer hydrogel Sferogel-light, medium and long. Material and methods. The article provides a personal experience in conservative treatment of osteoarthritis of the temporomandibular joint with heterogeneous biopolymer hydrogel Sferogel-light, medium and long. Sferogel is obtained from the hydrolyzed embryonic or postnatal collagen containing tissues of farm animals and comprises collagen, hyaluronic acid, chondroitin sulfate, heparin, a number of proteins (proteins of the complement system and blood plasma, interferons and antibodies) and monosaccharides (glucose, fructose, mannose, glucosamine, galactosamine, fructosamine and sialic acid). Results and discussion. The article presents an overview of modern methods of conservative treatment of osteoarthritis of the temporomandibular joint including the use of non-steroidal anti-inflammatory drugs systemically and topically as well as acetaminophen, chondroprotectors, intra-articular injections of corticosteroids, anesthetics or biopolymer drugs, such as collagen, hyaluronic acid, a mixture of stem cells and plasma or a combination of biopolymers. Conclusion. Sferogel is effective in treatment of osteoarthritis of the temporomandibular joint with a long positive effect.
Key words: temporomandibular joint, osteoarthrosis, heterogeneous biopolymer hydrogel, regeneration, chondrocytes.
For reference: Tarasov IV, Nikitin AA, Perova NV, Chukumov RM, Gusarov DE. Conservative treatment of arthrosis of the temporomandibular joint. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (4): 66—71.
REFERENCES
1. Sato H, Osterberg T, Ahlqwist M, Carlsson GE, Grondahl HG, Rubinstein B. Association between radiographic findings in the mandibular condyle and temporomandibular dysfunction in an elderly population. Acta Odontol Scand. 1996; 54 (6): 384–90.
2. Wang XD, Kou XX, Mao JJ, Gan YH, Zhou YH. Sustained inflammation induces degeneration of the temporomandibular
joint. J Dent Res. 2012; 91 (5): 499–505.
3. Alomar X, Medrano J, Cabratosa J, Clavero J, Lorente M, Serra I, Monill J, Salvador A. Anatomy of the temporomandibular joint. Seminars in Ultrasound, CT, and MRI. 2007; 28: 170–183.
4. Perova, N.V. Differencirovannyj podhod k doklinicheskoj ocenke biologicheskoj bezopasnosti implantatov [Differentiated
approach to the pre-clinical evaluation of biological safety of implants]. Moskva (Moscow). 2004; 221 p.
5. Brjuhoveckij IS, Djujzen IV, Motavkin PA. Morfohimicheskaja harakteristika spinnogo mozga krys posle torakal’noj segmentjektomii i transplantacii polimernogo kollagenovogo nejromatriksa «Sferogel’-Je»™ s inkorporirovannymi obkpadochnymi nejrojepitelial’nymi kletkami [Morphochemical characteristic of the spinal cord of rats after transplantation of thoracic segmentectomy and polymeric collagen neyromatriksa «Sferogel-E» ™ with incorporated obkpadochnymi neuroepithelial cells]. Geny i kletki [Genes and cells]. 2008; 3 (2): 57-62.
6. Porunova JuV, Perova NV, Ur’jash VF et al. Biodegradiruemyj kollagensoderzhashhij matriks Sferogel’ dlja bioiskusstvennyh organov i tkanej [Biodegradable collagen-containing matrix Spherogel for bioartificial organs and tissues]. Vestnik transplantologii i iskusstvennyh organov [Journal of Transplantology and Artificial Organs]. 2003; 4: 46–49.
7. Sajkovskij RS, Savenkova NA, Aver’janov AV, Lisica AV. Jeffektivnost’ primenenija preparata Sferogel’ dlja lechenija gonartroza [The effectiveness of Spherogel drug for the treatment of gonarthrosis]. Klinicheskaja praktika [Clinical practice]. 2013; 3: 4–10.
DISEASES OF THE CERVIX DURING PREGNANCY AND MODERN DIAGNOSTIC METHODS (the review of literature)
UDC 618.3-06:618.146(048.8)
DOI: 10.20969/VSKM.2016.9(4).72-83
ATABIYEVA ZHAMILIA A., graduate student of the Department of obstetrics and gynecology № 1 of medical faculty of I.M. Sechenov First Moscow State Medical University, Russia, 119991, Moscow, Trubetskaya str., 8, b. 2, tel. +7-968-565-08-80, e-mail: atabieva.jamilya@gmail.com
PIKUZA TATYANA V., obstetrician-gynecologist of the Department obstetric observation of V.F. Snegirev clinic of obstetrics and gynecology of I.M. Sechenov First Moscow State Medical University, Russia, 119991, Moscow, Trubetskaya str., 8, b. 2, tel. +7-903-170-63-30, e-mail: tatapikuza@mail.ru
CHILOVA RAISA A., D. Med. Sci., professor of the Department of obstetrics and gynecology № 1 of I.M. Sechenov First Moscow State Medical University, obstetrician-gynecologist of V.F. Snegirev clinic obstetrics and gynecology, Russia, 119991, Moscow, Trubetskaya str., 8, b. 2, tel. +7-985-761-91-35, e-mail: rtchilova@gmail.com
ZHUKOVA ELVIRA V., obstetrician-gynecologist, the highest category physician, Head of the Department of clinical and diagnostic № 1 of the University clinic № 2 of Clinic of obstetrics and gynecology of I.M. Sechenov First Moscow State Medical University, Russia, 119991, Moscow, Trubetskaya str., 8, b. 2, tel. +7-985-998-04-41, e-mail: zhukova.elvira@mail.ru
TRIFONOVA NATALYA S., C. Med. Sci., obstetrician-gynecologist of Clinic of obstetrics and gynecology of the University hospital № 2 of I.M. Sechenov First Moscow State Medical University, Russia, 119991, Moscow, Trubetskaya str., 8, b. 2, tel. +7-903-773-72-20, e-mail: trifonova.nataly@mail.ru
Abstract. Aim. To study cervical disease as it is one of the most common pathological conditions of the female reproductive system that does not tend to decrease. Material and methods. Review of local and foreign publications has been performed. The data from clinical trials has been studied. Results and discussion. The changes in cervical state give rise to numerous irregularities during pregnancy and make the management complicated. This review presents the current state of the problem of cervical pathological state. It describes the changes in the cervix during pregnancy as well as the risk of cervical disease among pregnant women. We provide the modern international classification of pathological cervical conditions including inflammatory diseases, background and precancerous state. The peculiarities of cervical disease in pregnant women are specified, advanced diagnostic and treatment methods are provided. Conclusion. This review is relevant in modern obstetrics and gynaecology due to the increasing incidence of emerging cervical pathology during pregnancy and beyond, as well as the absence the strict criteria for the diagnosis and treatment of this pathology.
Key words: cervix, pregnancy, cervical pathology, complications of pregnancy.
For reference: Atabiyeva JA, Pikuza TV, Chilova RA, Zhukova EV, Trifonova NS. Diseases of the cervix during pregnancy and modern diagnostic methods (the review). The Bulletin of Contemporary Clinical Medicine. 2016; 9 (4): 72—83.
REFERENCES
1. Rudakova EB, Prilepskaya VN ed. Vospalitelniye zabolevaniya sheyki matki I besplodiye: klinicheskiye lektsii [Inflammatory diseases of uteral cervix and sterility: clinical lectures]. Omsk: Medpress-inform. 2004; 1-15.
2. Chilova RA. Optimizatsiya antimikrobnoy terapii b ptrioperatsionnoy antibiotikoprofilaktiki byaektsiy u beremennih: dissertacia doktora medicinskih nauk [Antibiotic prophylaxis of infections in pregnant women: thesis of the doctor of medical sciences]. Moscow; 2006; 1-41.
3. Hetfild AS, Sanchez-Ramos L, Kaunitz M. Sonogrefik a cervical assessment to predict successof an odynagogue: the systematic review with the metaanalysis. Amer J Obstet Gynecol. 2007; 197 (2): 14-17.
4. Bulanov MN, Mit’kov VV. Sovremennoe predstavlenie o normal’noj ul’trazvukovoj anatomii i gemodinamike jendocerviksa [Modern idea of normal ultrasonic anatomy and hemodynamics of an endotserviks]. Ul’trazvukovaja i funkcional’naja diagnostika [Ultrasonic and functional diagnostics]. 2005; 2: 17-18.
5. Gusakova NS, Petukhov GS, Fokin TA et al. Zabolevaniya sheyki matki I beremennost [Diseases of a neck of a uterus and pregnancy]. Voprosi ginekologii, akusherstva I perinatalogii [Questions of gynecology, obstetrics and perinatology]. 2006; 5 (2): 18-23.
6. Bakhidze EV. Fertilnost, beremennost I ginekologicheski rak [Fertility, pregnancy and gynecologic cancer]. Moskva-Sankt-Peterburg: DILJa [Moscow — Saint Petersburg: Dilya]. 2004; 17-32.
7. Bernal KL, Fahmy L, Remmenga S et al. Embrionel’s rhabdomyosarcoma (a sarcoma botrioida) of the neck representing as a cervical polyp belonged with the surgery sparing a fertility and a useful chemotherapy. Gynecol Oncol. 2004; 95 (1): 24-29.
8. Krasnopolsky VI, Serova OF, Zarochentseva NV et al. Patologicheskiye izmeneniya sheyki matki pri beremennosti [Pathological changes in the cervix during pregnancy]. Akusherstvo I ginekologiya [Obstetrics and gynecology]. 2006; 4; 35-40.
9. Ozyorskaya IA, Ageeva MI. Ultrazvukovaya diagnostika zabolevaniy sheyki matki [Ultrasonic diagnosis of diseases of a neck of a uterus]. Ultrazvukovaya I funktsionalnaya diagnostika [Ultrasonic and functional diagnostics]. 2002; 2; 132-136.
10. Kolomeets EV. Beremennost I zabolevaniya sheyki matki: chastota, oslojneniya gestatsii,materinskiye I perinatalniye ishodi [Pregnancy and diseases of a neck of uterus: frequency, complications of a gestation, maternal and perinatal outcomes]. Oryel [Orel]. 2012; 18-161.
11. Prilepskaya VN ed. Patologiya sheyki matki i genitalniye infektsii [Ratologiya of a uterus neck and genital infections]. Moskva: MEDpress-inform [Moscow: Medical press-inform]. 2008; 4-16.
12. Cioni R, Bussani C, Skarselli B et al. Comparison of two echniques for transcervical selection of a cell acted in the same population of research. Prenative. 2005; 25: 198.
13. Glebova NN, Vekhnovsky VO, Korniyenko TG. Patologiya shejki matki [Uterus neck pathology]. Zdravoohranenie Bashkortostana [Health of Bashkortostan]. 1994; 1;
4-11.
14. Demidov BC. Klinicheskoye znacheniye doplerometrii v diagnostike I prognozirovanii platsentarnoy nedostatochnosti vo vtorom trimester beremennosti: avtoref. diss. kand. med. nauk [Clinical value of a dopplerometriya in diagnostics and forecasting of a placental failure in the second and third trimesters of pregnancy: abstract of the candidat of medical sciences]. Moskva [Moscow]. 2000: 42; 19-38.
15. Prilepskaya VN, Bykovskaya OV. Ureaplazmennaja infekcija v akusherstve i ginekologii sovremennyj vzgljad na problem [Ureaplasma infection in obstetrics and gynecology modern view on the problem]. Akusherstvo i ginekologija [Obstetrics and Gynecology]. 2007; 2: 9-11.
16. Strizhakov AN, Davydov AI, Belotserkovtseva LD. Klinicheskaya colposcopiya [Clinical kolposkopiya]. MediSICha. 2002; 4-14.
17. Zarochentseva NV. Zabolevaniya sheyki matki pri beremennosti: dissertacia doktora medicinskih nauk [Uterus neck diseases at pregnancy: thesis of the doctor of medical sciences]. Moskva [Moscow]. 2009; 275 p.
18. Lipman AD, Cheremnih AY. Ultrazvukoviye kriterii istmiko-tservikalnoy nedostatochnosti [Ultrasonic criteria of an istmiko-cervical failure]. Akusherstvo i ginekologija [Obstetrics and gynecology]; 1996; 4; 25-27.
19. Joshi B. Osnovy provedeniya ultrazvukovogo issledovaniya v pervom trimester beremennosti [Bases of carrying out ultrasonic research in the first trimester of pregnancy] SonoAce Intern — Russkaya versiya [Russian version]. 1998; 2; 46-50.
20. Khmelnytskyi OK. Tsitologicheskaya I gistologicheskaya diagnostika zabolevaniy tela I sheyki matki [Cytologic and histological diagnostics of diseases of a neck and body of the womb]. SPb: SOTIS. 2000; 20-35.
21. Bucciantini S, Barkyulli F, Skarselli G. Embryonic cells in cervical slime in the first trimester of pregnancy. Prenatal Diagnostic. 2003; 23: 15-23.
22. Duckitt K, Qureshi A. Recurrent misbirth. Am Fam Physician. 2008; 78 (8): 20-78.
23. Tareeva TG. Perinatalniye protsessi smeshannoy urogenitalnoy infektsii (patogenez, prognoz, profilaktika): autoref diss dok med nauk [Perinatal aspects of the admixed urogenital infection (a pathogenesis, the forecast, prophylaxis): abstract of the thesis of the doctor of medical sciences]. Moskva [Moscow]. 2000; 18-23.
24. Bulmer JN, Choni R, Bussani C et al. HLA-G positive trophoblastic of a cell in transcervical samples and theirisolation and the analysis a laser microsection and QF-PCR. Prenatal Diagnostic. 2003; 23: 8-35.
25. Unanyan AL, Kosovich YuM. Hronichesky cervicit: osobennosti etiologii, patogeneza, diagnostiki I lecheniya [Chronic tservitsit: features of pathogenesis, diagnostics and treatment]. Rossiyski vestnik akushera-ginekologa [Russian messenger of the obstetrician-gynecologist]. 2012; 6: 40-45.
26. Apolikhina IA, Denisova ED. Human Papillomavirusnaya infektsiya genitaliy: aktualnaya problema sovremennoy ginekologii I puti yeye resheniya [Papillomavirus infection of genitalias: actual problem of modern gynecology and way of its decision]. Voprosi ginekologii, akusherstva I perinatalogii [Questions of gynecology, obstetrics and perinatology]. 2007; 6 (6): 19-41.
27. Sidorova IS, Levakov SA. Fonoviye I predrakoviye protsessi sheyki matki [Background and precancer processes of a neck of a uterus]. Moskva [Moscow]: MIA; 2006; 37-41.
28. Shabalova IP, Kasoyan KT. Tsitologicheskiy atlas diagnostiki zabolevaniy sheyki matki [Cytologic atlas of diseases of a neck of a uterus]. Moskva [Moscow]: Triada — X. 2006; 18-93.
29. Carp HJA. Recurrent Loss of Pregnancy: Reasons, Spores and Treatment. Informa health care. 2007; 290 p.
30. Rusakevich PS. Litvinova TM. Zabolevaniya sheyki matki u beremennih: diagnostika, lecheniye, monitoring, profilaktika [Diseases of a neck of uterus at pregnant women: diagnostics, treatment, monitoring, prophylaxis]. Moskva [Moscow]: “Mia”. 2006; 14-20.
MANAGEMENT OF PREGNANT PATIENTS WITH CONGENITAL HEART DEFECTS
UDC 618.3-06:616.12-007-053.1(048.8)
DOI: 10.20969/VSKM.2016.9(4).83-88
VOLCHKOVA NATALYA S., C. Med. Sci., associate professor of the Department of internal and family medicine of Kazan State Medical Academy, Russia, 420012, Kazan, Mushtari str., 11, e-mail: natalyavolchkova@mail.ru
SUBKHANKULOVA SAIDA F., C. Med. Sci., assistant of professor of the Department of internal and family medicine of Kazan State Medical Academy, Russia, 420012, Kazan, Mushtari str., 11, e-mail: sfs-kazan@yandex.ru
SUBKHANKULOVA ASIA F., C. Med. Sci., associate professor of the Department of obstetrics and gynecology № 2 of Kazan State Medical University, Russia, 420012, Kazan, Butlerov str., 49, e-mail: asia-sf@mail.ru
Abstract. Congenital heart defects in pregnant women are a very common pathology in practice of cardiologist and obstetrician-gynecologist, which can cause complications at different stages of pregnancy. Aim. Analysis of the data on tactics of delivery in pregnant women with congenital heart disease. Material and methods. Review of publications of local and foreign authors from clinical and epidemiological studies. Results and discussion. Diagnostic approach, non-pharmacological and pharmacological correction of hemodynamic disorders, prevention of complications and tactics of delivery were presented from the perspective of evidence-based medicine, which should be a guide for practitioners engaged in management and treatment of such patients. Conclusion. Early detection, thorough clinical examination at pregravid stage, joint surveillance of cardiologist and obstetrician-gynecologist during gestation and timely provided aid will prevent possible complications in pregnant women with congenital heart disease and will help in choosing the best tactics of delivery (vaginal or operative).
Key words: pregnancy, congenital heart diseases, tactics of delivery.
For reference: Volchkova NS, Subhankulova SF, Subhankulova AF. Management of pregnant patients with congenital heart defects. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (4): 83—88.
REFERENCES
1. Aylamazyan EK, Kulakov VI, Radzinskii VE, Savel’eva GM. Akusherstvo [Obstetrics]: Nacional’noe rukovodstvo [Public management]. M: GEOTAR–Media. 2014; 668–674.
2. Marcevich SJu ed. Diagnostika i lechenie serdechno — sosudistyh zabolevanij pri beremennosti: rekomendacii RKO [Diagnosis and treatment of cardiovascular diseases during pregnancy: the recommendations of the CSC]. Rossijskij kardiologicheskij zhurnal [Russian journal of cardiology]. 2013; 4 (102, supp.1): 40 p.
3. Marcevich SJu ed. Racional’naja farmakoterapija bol’nyh s serdechno — sosudistymi zabolevanijami [Rational pharmacotherapy
of patients with cardiovascular diseases]. Kardiovaskuljarnaja terapija i profilaktika [Cardiovascular therapy and prevention]. 2009; 8 (6, supp. 4): 51 p.
4. Arutyunov GP. Diagnostika i lechenie zabolevanij serdca i sosudov [Diagnosis and treatment of diseases of the heart and blood vessels]. Moskva [Moscow]: GEOTAR — Media. 2013; 275– 300.
5. Apresyan SV. Beremennost’ i rody pri jekstragenital’noj patologii [Pregnancy and childbirth in extragenital pathology]. Moskva [Moscow]:GEOTAR — Media. 2009; 75–169.
6. Mravyan SR, Petrukhin VA, Pronin VP. Poroki serdca u beremennyh [Heart diseases in pregnancy]. St Petersburg: GEOTAR–Media. 2010; 160 p.
7. Oakley S, Marens K. Heart Disease in pregnant women. St Petersburg: Binom. 2010; 368 p.
8. Sokolova MYu. Jekstragenital’naja patologija u beremennyh: rukovodstvo dlja vrachej. [Extragenital pathology in pregnant women: a guide for physicians]. Moskva [Moscow]: MIA. 2011; 336 р.
9. Strjuk RI. Zabolevanija serdechno–sosudistoj sistemy i beremennost [Diseases of the cardiovascular system and pregnancy]. Moskva [Moscow]:»GEOTAR–Media». 2010; 308 р.
10. 1Shehtman MM. Rukovodstvo po jekstragenital’noj patologii u beremennyh [Guide on extragenital pathology in pregnant women]. Triad — N. 2008; 815 p.
11. 1Prikaz MZ RF № 572n ot 1.11.2012. «Ob utverzhdenii porjadka okazanija medicinskoj pomoshhi po profilju «akusherstvo i ginekologija (za iskljucheniem ispol’zovanija vspomogatel’nyh reproduktivnyh tehnologij)» s izmenenijami
na 11.06.2015. [Ministry of health order № 572N from 1.11.2012. «On approval of the procedure of rendering of medical aid in the field of «obstetrics and gynecology (except for the use of assisted reproductive technologies)» with changes on 11.06.2015].
12. European Society of Cardiology (ESC). Guidelines on the management of cardiovascular diseases during pregnancy: the Task Force on the management of Cardiovascular Diseases during Pregnancy. Eur Heart J. 2011; 32: 3147–3197.
13. Siu SC, Colman JM, Sorensen S et al. Adverse neonatal and cardiac outcomes are more common in pregnant women with cardiac disease. Circulation. 2002; 105: 2179–2184.
14. Drenthen W, Boersma E, Balci A, Moons P et al. Predictors of pregnancy complications in women with congenital disease. Eur Heart J. 2010; 31: 2124–2132.
MODERN METHODS OF MINIMALLY INVASIVE TREATMENT OF ARTHROSIS OF THE TEMPOROMANDIBULAR JOINT
UDC 616.724-007.248-08-039.73(048.8)
DOI: 10.20969/VSKM.2016.9(4).89-96
NIKITIN ALEXANDER A., D. Med. Sci., professor, Head of the Department of maxillofacial surgery, Head of the Department of maxillofacial surgery and surgical dentistry of Moscow Regional Research and Clinical Institute, Russia, 129110, Moscow, Shchepkin str., 61/2
TARASOV IVAN V., postgraduate student of the Department of maxillofacial surgery and surgical dentistry of Moscow Regional Research Clinical Institute, Russia, 129110, Moscow, Shchepkin str., 61/2, tel. +7-926-819-58-06, e-mail: martini-87@list.ru
PEROVA NADEZHDA V., D. Biol. Sci., deputy director of the Institute of Biomedical Research and Technology, Russia, 123557, Moscow, Bolshoy Tishinskiy lane, 43/2, bld. 2, tel. +7-926-607-66-25, e-mail: 89266076625@mail.ru
CHUKUMOV RINAT M., C. Med. Sci., researcher of the Department of maxillofacial surgery and surgical dentistry of Moscow Regional Research Clinical Institute, Russia, 129110, Moscow, Shchepkin str., 61/2
GUSAROV DANIIL E., postgraduate student of the Department of maxillofacial surgery and surgical dentistry of Moscow Regional Research Clinical Institute, Russia, 129110, Moscow, Shchepkin str., 61/2
Abstract. Degenerative-dystrophic diseases of joints take a leading place among all diseases of the joints and are a major cause of morbidity, activity limitations, disability and loss of quality of life in patients older than 45 years. Aim. To study current data on the problem of etiology, pathogenesis and treatment of osteoarthritis of the temporomandibular joint. Material and methods. Review of publications of local and foreign authors. Results and discussion. The paper describes etiological factors that contribute to osteoarthritis of the temporomandibular joint as well as the pathogenic mechanism and clinical diagnostic criteria. Analysis of the effectiveness of the main treatment for degenerative diseases. We describe the use of combined biopolymers. Indications and contraindications of introducing heterogeneous biopolymer hydrogel Sferogel. Conclusion. The use of intra-articular injection has a positive effect on symptoms of osteoarthritis of the temporomandibular joint, demonstrating relief of pain and improving functional ability of the joint. The necessity in additional studies of the combined use of biopolymer products.
Key words: temporomandibular joint, osteoarthrosis, heterogeneous biopolymer hydrogel, regeneration, chondrocytes.
For reference: Nikitin AA, Tarasov IV, Perova NV, Chukumov RM, Gusarov DE. Modern methods of minimally invasive treatment of arthrosis of the temporomandibular joint. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (4): 89—96.
REFERENCES
1. Alomar X, Medrano J, Cabratosa J, Clavero J, Lorente M, Serra I, Monill J, Salvador A. Anatomy of the temporomandibular joint. Seminars in Ultrasound, CT, and MRI. 2007; 28: 170–183.
2. Sato H, Osterberg T, Ahlqwist M, Carlsson GE, Grondahl HG, Rubinstein B. Association between radiographic findings in the mandibular condyle and temporomandibular dysfunction in an elderly population. Acta Odontol Scand. 1996; 54 (6): 384–90.
3. Wang XD, Kou XX, Mao JJ, Gan YH, Zhou YH. Sustained inflammation induces degeneration of the temporomandibular joint. J Dent Res. 2012; 91 (5): 499–505.
4. Perova NV. Differencirovannyj podhod k doklinicheskoj ocenke biologicheskoj bezopasnosti implantatov [Differentiated approach to the pre-clinical evaluation of biological safety of implants]. Moskva (Moscow). 2004; 221 p.
5. Sevastyanov VI, Perova NV, Saikovskij RS, Solovieva IV. Primenenie iniekcionnyh form biopolimernyh geterogennyh gidrogelej pri degenerativno-distroficheskih porazhenijah sustavov [The use of injectable biopolymer heterogeneous hydrogels with degenerative lesions of the joints]. Moskva [Moscow]: Triada. 2012; 27 p.
6. Brjuhoveckij IS, Djujzen IV, Motavkin PA. Morfohimicheskaja harakteristika spinnogo mozga krys posle torakal’noj segmentjektomii i transplantacii polimernogo kollagenovogo nejromatriksa «Sferogel’-Je»™ s inkorporirovannymi obkpadochnymi nejrojepitelial’nymi kletkami [Morphochemical characteristic of the spinal cord of rats after transplantation of thoracic segmentectomy and polymeric collagen neyromatriksa «Sferogel-E» ™ with incorporated obkpadochnymi neuroepithelial cells]. Geny i kletki [Genes and cells]. 2008; 3 (2): 57-62.
7. Porunova JuV, Perova NV, Ur’jash VF et al. Biodegradiruemyj kollagensoderzhashhij matriks Sferogel’ dlja bioiskusstvennyh organov i tkanej [Biodegradable collagen-containing matrix Spherogel for bioartificial organs and tissues]. Vestnik transplantologii i iskusstvennyh organov [Journal of Transplantology and Artificial Organs]. 2003; 4: 46–49.
8. Sevastyanov VI, Perova NV. Biopolimernyj geterogennyj gidrogel’ Sferogel’ — in’ekcionnyj biodegradiruemyj implantat dlja zamestitel’noj i regenerativnoj mediciny [Biopolymer heterogeneous hydrogel Sphero®GEL — an injectable biodegradable implant for replacement and regenerative medicine]. Prakticheskaja medicina [Practical Medicine]. 2014; 8 (84): 110–116.
9. Sajkovskij RS, Savenkova NA, Aver’janov AV, Lisica AV. Jeffektivnost’ primenenija preparata Sferogel’ dlja lechenija gonartroza [The effectiveness of Spherogel drug for the treatment of gonarthrosis]. Klinicheskaja praktika [Clinical practice]. 2013; 3: 4–10.
UDC 616.833-056.76-053.2
DOI: 10.20969/VSKM.2016.9(4).97-100
MARULINA VALENTINA I., C. Med. Sci., associate professor of the Department of pediatric neurology of Kazan State Medical Academy, Russia, 420012, Kazan, Mushtary str., 11, tel. (843) 273-49-09, e-mail: marulina_vi@mail.ru
KNYAZEVA OLESYA V., C. Med. Sci., assistant of professor of the Department of pediatric neurology of Kazan State Medical Academy, Russia, 420012, Kazan, Mushtary str., 11, tel. (843) 273-49-09, e-mail: knyazeva.dnevr@mail.ru
BOLSHAKOVA TATYANA A., neurologist of Children’s City Hospital № 8, Russia, 420061, Kazan, Galeev str., 11, tel. (843) 273-49-09, e-mail: detbol8@mail.ru
Abstract. Hereditary neuropathies are widespread diseases of peripheral nervous system. In majority of cases they are characterized by steady progression. One of such diseases is hereditary neuropathy with predisposition to paralysis from compression. Difficulties in diagnostics and clinical manifestations characterized by frequent relapsing mononeuropathies caused by hypersensitivity to compression require the depth study of this disease. Aim — to analyze the features of hereditary neuropathy with predisposition to paralysis from compression on clinical case. Material and methods. Forms of hereditary neuropathy with predisposition of paralysis, clinical features and diagnostics methods according to the literature and case report of a special form of demyelinating polyneuropathy were presented. Results and discussion. Our results confirm higher prevalence of such neuropathies. Conclusion. The results demonstrate different forms of the disease and possible «masks».
Key words: children, nervous diseases, paralysis from a neurothlipsia, hereditary diseases.
For reference: Marulina VI, Knyazeva OV, Bolshakova TA. Clinical case of special form of demyelinating polyneuropathy: hereditary neuropathy with predisposition to paralysis from compression. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (4): 97—100.
REFERENCES
1. Levin OS. Polinevropatii: klinicheskoe rukovodstvo. [Polyneuropathies: clinical management]. M: MIA. 2005; 495 p.
2. Behse F. Hereditary neuropathy with liability to pressure palsies. Electrophysiological and histopathological aspects. Brain. 1972; 95: 777-794.
3. Zolotareva GI. Trudnosti differencial’nogo diagnoza nasledstvennoj nevropatii u detej [Difficulties of the differential diagnosis of a hereditary neuropathy in children]. Dal’nevostochnyj medicinskij zhurnal [Far East medical magazine]. 2004; 2: 65-67.
4. Chance PP. Hereditary neuralgic amyotrophy and hereditary neuropathy with liability to pressure palsies: two distinct genetic disorders. Neurology. 1994; 44: 2253-2257.
5. Goncharova SI. Nasledstvennaja nevropatija Sharko—Mari—Tuta: vozmozhnosti nefarmakologicheskogo lechenija [Hereditary neuropathy of Sharko—Mari—Tuta: possibilities of not pharmacological treatment]. Fizioterapija, bal’neologija i reabilitacija [Physical therapy, balneology and rehabilitation]. 2013; 6: 13-19.
6. Rumjanceva NV. Nasledstvennaja nevropatija s predraspolozhennost’ju k paralicham ot sdavlenija: geneticheskie
osnovy, klinicheskie projavlenija, diagnostika [Hereditary neuropathy with predisposition to compression paralysis: genetic bases, clinical manifestations, diagnostics].
Nevrologija i nejrohirurgija Vostochnaja Evropa [Neurology and neurosurgery Eastern Europe]. 2015; 1 (25): 49-61.
7. Kuanova LB. Nasledstvennaja nevropatija so sklonnost’ju k paralicham ot sdavlenija [Hereditary neuropathy with tendency to compression paralysis]. Zhurnal nevrologii i psihiatrii imeni CC Korsakova [Magazine of neurology and psychiatry of CC Korsakova]. 2010; 110 (1): 95-96.
UDC [616-002.5:616.98:578.828HIV]-078
DOI: 10.20969/VSKM.2016.9(4).101-107
SENIN ANDREY M., postgraduate student of Ural Scientific Research Institute of Phthisiopneumology, Head of affiliate TB dispensary № 2, Russia, 623100, Sverdlovsk region, Pervouralsk, Gagarin str., 46, tel. 8-343-966-20-49, e-mail: filial2_ptd@mail.ru
EISMONT NATALIA V., D. Med. Sci, senior researcher of Ural Scientific Research Institute of Phthisiopulmonology, deputy chief doctor of Rabukhin Tuberculosis hospital, Russia, 141504, Moscow region, Solnechnogorsk, Rabukhin str., 7, tel. 8-496-264-62-18, e-mail: tb11@zdrav.mos.ru
GOLUBEV DMITRIY N., D. Med. Sci, professor, chief researcher of Ural Scientific Research Institute of Phthisiopulmonology, Russia, 620039,Yekaterinburg, XXII Parts’ezd str., 50, tel. 8-912-222-24-02, e-mail: golubev-d50@mail.ru
Abstract. Aim. Assessment of effectiveness of recombinant tuberculin in determination of activity of tuberculosis (TB) process in patients with HIV co-infection. Material and methods. The results of the «Diaskintest®» of 207 patients with HIV and TB infection co morbidity at different state of the disease were studied. Comparison of test results between a group of patients with active TB and a group of patients with clinically cured TB was held. Results and discussion. Significant prevalence of positive samples in individuals with active TB at different states compared to ones with clinically cured TB was revealed. There was a statistically significant prevalence of patients with deep immune deficiency in individuals with active TB. Statistically significant predominance of negative samples was revealed in persons with clinically treated TB comparing to patients with an active process. The sensitivity of the test for patients with HIV infection in combination with newly diagnosed TB was 78,2%, in combination with exacerbations and relapses of TB was 76,2%. Conclusion. «Diaskintest®» is an effective additional method of follow-up, determining the activity of the TB process in TB patients with HIV co-infection.
Key words: tuberculosis, HIV infection, «Diaskintest».
For reference: Senin AM, Eismont NV, Golubev DN. «Diaskintest®» as evaluation of activity of the disease in patients with tuberculosis and HIV co-infection. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (4): 101—107.
REFERENCES
1. Bogorodskaja EM. Formirovanie u bol’nyh tuberkulezom stimulov k vyzdorovleniju i sobljudeniju rezhima himioterapii [Formation in patients with tuberculosis of incentives for recovery and adherence chemotherapy]. Problemy tuberkuleza i boleznej legkih [Problems of tuberculosis and lung diseases]. 2007; 3: 46–64.
2. Cybikova JeB. Jepidemiologicheskie indikatory tuberkuleza, sochetannogo s VICh — infekciej [Epidemiological indicators of TB HIV co — infection]. Jelektronnyj nauchnyj zhurnal «Social’nye aspekty zdorov’ja naselenija» [Electronic scientific journal «Social aspects of population health»]. 2012; 5: http://vestnik.mednet.ru/content/view/438/30/lang.ru.
3. Nechaeva OB. Monitoring i ocenka jepidemiologicheskih pokazatelej po tuberkulezu v Rossijskoj Federacii [Monitoring and evaluation of epidemiological indicators of tuberculosis in the Russian Federation]. Tuberkulez i bolezni legkih [Tuberculosis and lung disease]. 2012; 8: 16–22.
4. Jejsmont NV. Nauchnoe obosnovanie i razrabotka sistemy organizacii protivotuberkuleznoj pomoshhi bol’nym s VICh–infekcii v Rossijskoj Federacii [Scientific substantiation and development of the organization of TB care to patients with HIV infection in the Russian Federation]. Moskva [Moscow]. 2013; 47 p.
5. Nechaeva OB, Jejsmont NV. Vlijanie VICh–infekcii na razvitie jepidemicheskoj situacii po tuberkulezu v Rossijskoj Federacii [The impact of HIV infection on the development of the epidemiological situation on tuberculosis in the Russian Federation]. Jelektronnyj nauchnyj zhurnal «Social’nye aspekty zdorov’ja naselenija» [Electronic scientific journal «Social aspects of population health]. 2011; 3: http://vestnik.mednet.ru/content/view/315/30/lang.ru.
6. Jejsmont NV, Senin AM, Podymova AS. Rezul’taty ispol’zovanija Diaskintesta i tuberkulinovoj proby Mantu s 2TE pri diagnostike tuberkuleza u bol’nyh s pozdnimi stadijami VICh–infekcii [The results of using Diaskintest and tuberculin Mantoux test 2ТЕ in the diagnosis of tuberculosis in patients with advanced HIV infection]. Ftiziatrija i pul’monologija [Phthisiology and pulmonology]. 2013; 2 (7): 26–27.
7. Pokrovskogo VV ed. VICh–infekcija i SPID: nacional’noe rukovodstvo [HIV infection and AIDS: national guidelines]. Moskva [Moscow]: GJeOTAR — Media. 2013; 608 p.
8. Gashenko AV. Sovershenstvovanie organizacii rannego vyjavlenija, dispansernogo nabljudenija i monitoringa tuberkuleza, sochetannogo s VICh–infekciej [Improvement of early detection and dispensary observation and monitoring of TB / HIV co–infection]. Moskva [Moscow]. 2010; 24 p.
9. Babaeva IJu, Zemskova ZS, Gedymin LE et al. Patomorfologicheskie osobennosti tuberkuleza legkih na raznyh stadijah VICh–infekcii (po dannym autopsii) [Pathologic features of pulmonary tuberculosis at different stages of HIV infection (according to autopsy)]. Problemy tuberkuleza i boleznej legkih [Problems of tuberculosis and lung diseases]. 2007; 12: 38–41.
10. Frolova OP, Polesskij VA, Novoselova OA et al. Tuberkulez u bol’nyh VICh–infekciej kak nacional’naja problema [Tuberculosis in HIV–infected patients as a national problem]. Tuberkulez i bolezni legkih [Tuberculosis and lung disease]. 2013; 3: 17–21.
11. Jejsmont NV, Nechaeva OB, Spiridonova LG. Zabolevaemost’ tuberkulezom i smertnost’ ot nego bol’nyh VICh–infekciej v Sverdlovskoj oblasti [The incidence of tuberculosis and mortality in HIV–infected patients in the Sverdlovsk region]. Jelektronnyj nauchnyj zhurnal «Social’nye aspekty zdorov’ja naselenija» [The Electronic scientific journal «Social aspects of population health]. 2011; 4: http://vestnik.mednet.ru/content/view/345/30/lang.ru.
12. Prikaz Minzdravsocrazvitija Rossijskoj Federacii ot 29 oktjabrja 2009 g. № 855 «O vnesenii izmenenij v prilozhenie № 4 k prikazu Minzdrava Rossii ot 21 marta 2003 g. № 109» [The order of the health Ministry of the Russian Federation of 29 October 2009 no. 855 «On making amendments into the Appendix № 4 to the order of Ministry of health of Russia from March 21, 2003,
№ 109»].
13. Prikaz Minzdrava Rossii ot 29 dekabrja 2014 g. № 951 «Ob utverzhdenii metodicheskih rekomendacij po sovershenstvovaniju diagnostiki i lechenija tuberkuleza organov dyhanija» [The order of Ministry of health of Russia from December 29, 2014 № 951 «On approval of methodological recommendations on improvement of diagnosis and treatment of tuberculosis of respiratory organs»].
14. Tursunova NA. Tuberkulinodiagnostika i himioprofilaktika tuberkuleza u VICh–inficirovannyh bol’nyh [Tuberculin diagnostics and prophylaxis of tuberculosis in HIV–infected patients]. SPb. 2006; 104 p.
15. Pal’cev MA ed. Kozhnaja proba s preparatom «Diaskintest» — novye vozmozhnosti identifikacii tuberkuleznoj infekcii [A skin test with the preparation «Diaskintest» — new possibilities of identification of TB infection]. Moskva: Medicina [Moscow: Medicine]. 2010; 40–42.
