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LEADING ARTICLE
ORIGINAL ARTICLES
REVIEWS
Pertussis at the present stage. Nicolaeva I.V., Shaikhieva G.S. P.25
CLINICAL LECTURES
Diagnostic and treatment of prolonged jaundice in young infants. Volyanyuk E.V. P.42
Respiratory manifestations of gastroesophageal reflux in children. Zakirov I.I., Safina A.I. P.47
Kawasaki syndrome: clinical pathways and the problem of underdiagnosis. Lutfullin I.Ya. P.52
Modern approaches to nutrition of children from 1 year to 3 years. Safina A.I. P.77
Vitamin and mineral complexes in pediatrics. Faizullina R.A., Zakirova A.M. P.98
ORGANIZATION OF HEALTHCARE
THESIS RESEARCHES
SHORT MESSEGES
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UDC 616-053.2:378.661(470.41-25)(091)
DOI: 10.20969/VSKM.2016.9(2).13-20
SAFINA ASIYA I., D. Med. Sci., professor, Head of the Department of pediatrics and neonatology of Kazan State Medical Academy, Russia, 420012, Kazan, Mushtari str., 11, tel. +7(843)562-52-66, e-mail: safina_asia@mail.ru
LUTFULLIN ILDUS YА., C. Med. Sci., associate professor of the Department of pediatrics and neonatology of Kazan State Medical Academy, Russia, 420012, Kazan, Mushtari str., 11, Head of the Department of pediatrics № 1 of city children's Hospital № 1 of Kazan, Russia, 420000, Kazan, Dekabrist, str., 125a, e-mail: lutfullin@list.ru
DAMINOVA MARIA A., C. Med. Sci., assistant of professor of the Department of pediatrics and neonatology of Kazan State Medical Academy, Russia, 420012, Kazan, Mushtari str., 11, tel. +7(843)562-52-66, e-mail: daminova-maria@yandex.ru
STEPANOVA OLGA A., C. Med. Sci., associate professor of the Department of pediatrics and neonatology of Kazan State Medical Academy, Mushtari str., 11, Russia, 420012, Kazan, tel. +7(843)562-52-66, e-mail: kafped@yandex.ru
RYBKINA NADEZHDA L., C. Med. Sci., associate professor of the Department of pediatrics and neonatology of Kazan State Medical Academy, Russia, 420012, Kazan, Mushtari str., 11, tel. +7-927-434-56-64, e-mail: natasha160899@yandex.ru
VOLYANYUK ELENA V., C. Med. Sci., associate professor of the Department of pediatrics and neonatology of Kazan State Medical Academy, Russia, Kazan, Mushtari str., 11, tel. +7(843)562-52-66, e-mail: volanuk@mail.ru
ZAKIROV ILNUR I., C. Med. Sci., associate professor of the Department of pediatrics and neonatology of Kazan State Medical Academy, Russia, 420012, Kazan, Mushtari str., 11, tel. +7(843)562-52-66, e-mail: zakirov.ilnur@inbox.ru
POTAPOVA MARINA V., C. Med. Sci., chief physician of city children's Hospital № 1 of Kazan, assistant of professor of the Department of pediatrics and neonatology of Kazan State Medical Academy, Russia, 420000, Kazan, Decabrist str., 125a, e-mail: detpol1.kzn@tatar.ru
IGNASHINA ELENA G., C. Med. Sci., Head of the Department of organization of medical care to children and services of obstetric aid, assistant of professor of the Department of pediatrics and neonatology of Kazan State Medical Academy, Russia, 420111, Kazan, ostrovsky str., 11/6, tel. +7(843)231-79-82, e-mail: elena.ignashina@tatar.ru
SADRUTDINOV MARAT A., assistant of professor of the Department of pediatrics and neonatology of Kazan State Medical Academy, Head of the Department of anesthesiology and intensive care № 3 of children's republican clinical Hospital, Russia, 420012, Kazan, Mushtari str., 11, tel. +7(843)562-52-66, e-mail: marat.satrutdinov@tatar.ru
GANIEVА RAISA T., C. Med. Sci., assistant of professor of the Department of pediatrics and neonatology of Kazan State Medical Academy, Russia, 420012, Kazan, Mushtari str., 11, tel. +7(843)562-52-66, е-mail: epicris21@gmail.com
Abstract. In 2016 marks 60 years since the foundation of the Department of Pediatrics and Neonatology in Kazan State Medical Academy The article provides a brief sketch of the history of the Department of Pediatrics and Neonatology since the foundation of the department in 1956 to the present day. Material and methods. Study of archival materials was conducted, memories and publications department staff over the years were reviewed. Results and discussion. An information about the main activities of the department, heads of department employees of the department and clinical sites is given in chronological order. Conclusion. Since the development of medicine is possible only in close tandem of practice and science, the principle of the priority of the collective of the department of pediatrics and neonatology remains close cooperation with the medical practice. Today the Department has a strong clinical base for training young doctors and professional development of students. Teaching stuff of the department in the pays great attention to the latest scientifc developments, taking into account international experience.
Key words: Department of pediatrics and neonatology, Kazan State Medical Academy, history of medicine.
For reference: Safna AI, Lutfullin IY, Daminova MA, Stepanova OA, Rybkina NL, Volyanyuk EV, Zakirov II, Potapova MV, Ignashina EG, Satrutdinov MA, Ganieva RT. History of the department of pediatrics and neonatology Kazan State Medical Academy (60 anniversary of the foundation). The Bulletin of Contemporary Clinical Medicine. 2016; 9 (2): 13—20.
References
1. Safna AI, Lutfullin IYa. Detskaja gorodskaja bol'nica № 1 Kazani i kafedra pediatrii i neonatologii KGMA: edinyj kurs razvitija [AI City Children's Hospital № 1 Kazan and the Department of Pediatrics and Neonatology Kyrgyz State Medical Academy: a single course of development]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Contemporary Clinical Medicine]. 2013; 6 (2): 14-16.
2. Zyjatdinov KSh. Medicinu nel'zja vyuchit' do konca: ot pediatrii do neonatologii [From pediatrics to neonatology: medicine can not be learned until the end]. Kazan': Slovo [Kazan: Word]. 2010; 178-183.
UDC 616.5-053.2-085.2/.3
DOI: 10.20969/VSKM.2016.9(2).21-24
MALANICHEVA TATIANA G., D. Med. Sci., professor of the Department of general medical practice of Kazan State Medical university, Russia, 420012, Kazan, Butlerov str., 49, e-mail: tgmal@mail.гu
ZIATDINOVA NELLI V., C. Med. Sci., associate professor of the Department of general medical practice of Kazan State Medical university, Russia, 420012, Kazan, Butlerov str, 49, e-mail: ziatdin@mail.гu
ZAKIROVA ALFIA M., C. Med. Sci., associate professor of the Department of general medical practice of Kazan State Medical university, Russia, 420012, Kazan, Butlerov str, 49, e-mail: azakirova@gmail.com
Abstract. A research objective was to improve the therapy of the atopic dermatitis (AD) in children complicated by a secondary fungal and bacterial infection. Material and methods. 82 patients from 6 months to 15 years with the complicated AD forms of staphylococcal and fungal infection were examined. Clinical effciency of antibacterial and antifungal therapy as a part of complex treatment the AD was estimated on the basis of the general and individual therapeutic effect, and also on the average duration of the periods of an aggravation and remission. Patients with the AD were divided into 2 groups: the main group consisted of 42 children, and control group — 40 children. Children of the main group received medication with antimicrobic action as a part of complex therapy, and in control group — only traditional antiallergic treatment. Results and discussion. The assessment of effciency of the carried-out therapy showed that the general therapeutic effect in the main group was 85,3%, and in the control — 9,7%, and the SCORAD index decreased respectively in 2,2 times — from 65 to 29,5 points and in 1,4 times — from 64 to 45 points. The high individual therapeutic effect in the main group was noted in 57% of cases whereas in control group it was absent. Absence of effect in group of the patients receiving antibacterial and antifungal therapy was noted in 7,6 times less than in children who has not received it. Duration of the aggravation period in the main group was reduced twice, the frequency of aggravations decreased in 4 times, and remission increased in 3,5 times. Conclusion. Application of the antibacterial and antifungal therapy at the AD in children, complicated by a secondary bacterial and fungal infection, results in high clinical effciency, short-term and long-term positive results, allows stopping in due time the infection and the allergic infammation of skin.
Key words: atopic dermatitis, complicated by secondary infection, children, treatment.
For reference: Malanicheva TG, Ziatdinova NV, Zakirova AM. Features of extemal and systemic pharmacotherapy of atopic dermatitis complicated by secondary infection in children. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (2): 21—24.
References
1. Malanichrva TG, Ziatdinova HV, Zakirova AM, Denisova CN. Izmenenie mikrobiotsenoza kozhi u detej s atopicheskim dermatitom oslozhnennym vtorichnoj infektsiej [Changes of skin microbiocenosis in children with atopic dermatitis complicated by secondary infection]. Voprosy prakticheskoj pediatrii. [Issues of Practical Pediatrics]. 2012; 4: 71–74.
2. Lavrentev EB ed. Atopicheskij dermatit i infektsii kozhi u detej diagnostika lechenie i proflaktika posobie dlya vrachej [Atopic dermatitis and skin infection in children: diagnosis, treatment and prevention: a manual for physicians]. M: Medpraktika. 2004: 104 p.
3. Kaznacheev KS, Kaznacheeva LF, Molokova AV, Rychkova IA, Dybrovina NA. Ratsionalnaya terapiya i uhod za kozhej detej s atopicheskim dermatitom [Rational therapy and skin care in children with atopic dermatitis]. Russkij meditsinskij zhurnal [Russian Medical Journal]. 2005; 5: 252–255.
4. Smirnova GI. Sovremennye podhody k lecheniyu i reabilitatsii atopicheskogo dermatita oslozhnennogo vtorichnoj infektsiej [Modern approaches to treatment and rehabilitation of atopic dermatitis complicated by secondary infection]. Allergologiya i immunologiya v pediatrii [Allergy and immunology in pediatrics]. 2004; 1: 34–39.
5. Smolkin JuS ed. Soglasitel'nyj dokument Associacii detskih allergologov i immunologov Rossii [Conciliation Document Association of Pediatric Allergology and Immunology Russian]. Allergologiya i immunologiya v pediatrii [Allergy and immunology in pediatrics]. 2004; 2–3: 111 p.
PERTUSSIS AT THE PRESENT STAGE
UDC 616.921.8(048.8)
DOI: 10.20969/VSKM.2016.9(2).25-29
NICOLAEVA IRINA V., D. Med. Sci., associate professor of the Department of children infections of Kazan State Medical university, Russia, Kazan, Butlerov str., 49, tel. 8-960-037-70-17, e-mail: irinanicolaeva@ mail.ru
SHAIKHIEVA GULNARA S., C. Med. Sci., graduate student of the Department of children infections of Kazan State Medical university, Russia, Kazan, Butlerov str., 49, tel. 8-917-245-93-10, e-mail: studentgulya@yandex.ru
Abstract. Despite the high level of vaccination coverage, pertussis remains an important cause of child morbidity and mortality worldwide. In many countries, there is an epidemic of pertussis, and a signifcant proportion among patients are vaccinated people. The aim of the article was to analyze the causes of the growth of incidence today. To review the characteristics of course, diagnosis, treatment and prevention of pertussis in children and adults. Material and methods. A review publications of domestic and foreign authors, the clinical recommendations for diagnosis, treatment and prevention of pertussis were carried out, data from randomized clinical trials and epidemiological researches was studied. Results and discussion. Modern data on the epidemiology of pertussis, peculiarities of its clinical manifestations, diagnosis and treatment in different age groups are presented. Conclusions. The increased incidence of pertussis may be associated with changes in the antigenic structure of the pathogen, the short duration of post-vaccination immunity, lower vaccination coverage, using more sensitive methods of laboratory diagnostics. Among the cases predominated teenagers and adults who suffer pertussis mainly in atypical forms. Severe and complicated forms of pertussis, as well as lethal outcomes were characteristic of children during the frst months of life. The use in clinical practice of modern pertussis diagnosis and treatment methods can reduce the duration and severity of clinical manifestations, as well as limit the spread of infection. There is a need to improve vaccination strategies against pertussis, maintain a high level of vaccination coverage and strict adherence of epidemiology in the nidus of infection.
Key words: pertussis, epidemiology, diagnosis, treatment, prevention.
For reference: Nicolaeva IV, Shaikhieva GS. Pertussis at the present stage. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (2): 25—29.
References
1. Bettiol S, Wang K, Thompson MJ et al. Symptomatic treatment of the cough in whooping cough. Cochrane Database Syst Rev. 2012; 5 (CD003257).
2. Gosudarstvennyj doklad o sostojanii sanitarno-jepidemiologicheskogo blagopoluchija naselenija v Rossijskoj Federacii v 2014 godu [State report about the state sanitary and epidemiological welfare of the population in the Russian Federation in 2014 ]. М: Federal Supervision Agency for Customer Protection and Human Welfare. 2015; 206 р.
3. Tatochenkо VK. Kokljush — nedoupravljaemaja infekcija [Pertussis — uncontrolled infection]. Voprosy sovremennoj pediatrii [Questions of current pediatrics]. 2014; 13(2): 78–82.
4. Liko J, Steve G. Robison. Priming with whole-cell versus acellular pertussis vaccine. N Engl J Med. 2013; 7: 581–582.
5. Cherry JD. Why do pertussis vaccines fail. Pediatrics. 2012; 129: 968–970.
6. Lapij FI. Aktual'nost' jeffektivnoj zashhity protiv kokljusha [The rationale of effective protection against pertussis]. Zdorov'e rebenka [Child health]. 2010; 3: 86.
7. Bisgard KM, Pascual FB, Ehresmann KR et al. Infant pertussis: who was the source. Pediatr Infect Dis J. 2004; 23: 985–989.
8. Lobzin YV, Bakhareva NV. Retrospective Study of the Clinical Epidemiological Characteristics of Pertussis in Infants Prior to Their First Vaccination in the Russian Federation. Infect Dis Ther. 2015; 4 (1): 113–123.
9. Sizemov AN, Komeleva EV Kokljush: klinika, diagnostika, lechenie [Pertussis: clinical fndings, diagnosis, treatment ]. Lechashhij vrach [Doctor in charge]. 2005; 7: 82–87 .
10. Centers for Disease Control and Prevention (CDC). Pertussis (Whooping Cough), Clinicians, Clinical Complications. 2012; Available at: http:/www.cdc.gov/ pertussis/clinical/features.html
11. Centers for Disease Control and Prevention. Pertussis-United States, 1997–2000. MMWR. 2002; 51 (4): 73.
12. Kundraft SL, Wolek TL, Rowe–Telow M. Malignant pertussis in the pediatric intensive care unit. Dimens Crit Care Nurs. 2010; 29: 1–5.
13. Rowlands HE, Goldman AP, Harrington K et al. Impact of rapid leukodepletion on the outcome of severe clinical pertussis in young infants. Pediatrics. 2010; 126: 816–827.
14. Theilen U, Johnston ED, Robinson PA. Rapidly fatal invasive pertussis in young infants–how can we change the outcome. BMJ. 2008; 27: 337– 343.
15. Proflaktika kokljusha: sanitarno–jepidemiologicheskie pravila SanPiN 3.1.2.3162–14 [Pertussis prevention: health and hygiene rules 3.1.2.3162–14]. М. 2014; Available at: http://36.rospotrebnadzor.ru/documents/ san_nor/14982
16. Tiwari T, Murphy TV, Moran J. Recommended antimicrobial agents for the treatment and postexposure prophylaxis of pertussis: CDC guidelines. Centers for Disease Control. 2005; 54 (RR–14): 1–16.
CURRENT APPROACHES TO PROPHYLAXIS AND TREATMENT OF BRONCHOPULMONARY DYSPLASIA
UDC 616.233/.24-007.17-053.32(048.8)
DOI: 10.20969/VSKM.2016.9(2).29-35
OVSYANNIKOV DMITRY YU., D. Med. Sci., Head of the Department of pediatrics of Peoples' friendship univercity of Russia, 117198, Moscow, Miklukho-Maklay str., 8, tel. +7(499)236-11-52, е-mail: mdovsyannikov@yahoo.com
BOLIBOK ANNA M., assistant of professor of the Department of pediatrics of Peoples' friendship univercity of Russia, 117198, Moscow, Miklukho-Maklay str., 8, tel. +7(499)236-11-52, е-mail: anulie@rambler.ru
DANIEL-ABU MADZHISOLA, postgraduate sudent of the Department of pediatrics of Peoples' friendship univercity of Russia, 117198, Moscow, Miklukho-Maklay str., 8, tel. +7(499)236-11-52
Abstract. Aim — to formulate and prove from positions of evidence based medicine application of interventions and drug treatment in children with the bronchopulmonary dysplasia. Material and methods. The analysis of results of randomized clinical trials, systematic reviews and meta-analyses on application of early CPAP, technique of INSURE, LISA, artifcial ventilation of the lungs, control of an oxygenation and oxygenotherapy, metilksantin, admission of steroids, inhalation bronchodilators, palivizumab. Results and discussion. Data on effciency of early CPAP; selective introduction of surfactant; INSURE and LISA methods was obtained. Are shown adverse effects of a hyperoxia in oxygen-dependent children target SatO2 was 90—95%. Data on use of caffeine taking into account its summarized positive effects (extubation acceleration, reduction of oxygen-dependency and frequencies of formation of BLD, apnea and adverse neurologic outcomes e.t.c). Positive effects, as from early, and late use of corticosteroids didn't outweigh side effects, and in long-term prospect the risk of neurologic pathology increases. Application of the inhaled bronchodilators had a positive effect only in case of bronchial obstruction, but not as a routine use. Reduction of serious lower respiratory tract infections frequency by RS-virus at children of groups of risk at passive immunization by a preparation Palivizumab was demonstrated. Conclusions. Current trends in prophylaxis and treatment of the bronchopulmonary dysplasia included the sparing methods of respiratory support, strictly reasonable indications to steroids and bronchodilators use, prophylaxis of RS-virus infections.
Key words: bronchopulmonary dysplasia, therapy, prevention, randomized clinical trials, meta-analysis, evidence-based medicine.
For reference: Ovsyannikov DYu, Bolibok AM, Daniel-Abu M. Current approaches to prophylaxis and treatment of bronchopulmonary dysplasia. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (2): 29—35.
References
1. Finer NN, Carlo WA, Walsh MC, et al. SUPPORT Study Group of the Eunice Kennedy Shriver NICHD Neonatal Research Network. Early CPAP versus surfactant in extremely preterm infants. N Engl J Med. 2010; 362: 1970–1979.
2. Sandri F, Plavka R, Ancora G, et al. CURPAP Study Group: Prophylactic or early selective surfactant combined with nCPAP in very preterm infants. Pediatrics. 2010; 125: 1402–1409.
3. Rojas-Reyes MX, Morley CJ, Soll R. Prophylactic versus selective use of surfactant in preventing morbidity and mortality in preterm infants. Cochrane Database Syst Rev. 2012: CD000510.
4. Stevens TP, Harrington EW, Blennow M, et al. Early surfactant administration with brief ventilation vs. selective surfactant and continued mechanical ventilation for preterm infants with or at risk for respiratory distress syndrome. Cochrane Database Syst Rev. 2007: CD003063.Verder H, Robertson B, Greisen G, et al. Surfactant therapy and nasal continuous positive airway pressure for newborns with respiratory distress syndrome. Danish-Swedish Multicenter Study Group. N Engl J Med. 1994; 331: 1051-1055.
6. Sweet DG, Carnielli V, Greisen G, et al. European consensus guidelines on the management of neonatal respiratory distress syndrome in preterm infants — 2013 update. Neonatology. 2013; 103: 353-368.
7. Lemyre B, Davis PG, De Paoli AG et al. Update Cochrane review: comparative analysis of the use of two modes of mechanical ventilation nasal intermittent positive (NIPPV) and continuous positive airway pressure (NCPAP) in preterm infants after extubation. Cochrane Database Syst Rev. 2014; 9: CD003212.
8. Gebel V, Krebs A, Cartel H, et al. Maloinvasivnoe vvedenie surfaktanta privodit k uluchsheniiu respiratornih ishodov u nedonoshennih na samostoiatelnom dihanii [The introduction of minimally Invasive surfactant leads to improved respiratory outcomes in premature self breath]. Neonatologia: novosti, mnenie, obuchenie [Neonatology: news, opinion, training]. 2015; 2 (8): 34-41.
9. Erickson SJ, Grauaug A, Gurrin L et al. Hypocarbia in the ventilated preterm infant and its effect on intraventricular haemorrhage and bronchopulmonary dysplasia. J Paediatr Child Health. 2002; 38: 560-562.
10. The STOP-ROP Multicenter Study Group. Supplemental therapeutic oxygen for prethreshold retinopathy of prematurity, a randomized, controlled trial. Pediatrics. 2000; 105: 295-310.
11. Askie LM, Henderson-Smart DJ, Irwig L, et al. Oxygen saturation targets and outcomes in extremely preterm infants. N Engl J Med. 2003; 349: 959-967.
12. SUPPORT Study Group of the Eunice Kennedy Shriver NICHD Neonatal Research Network. Carlo WA, Finer NN, Walsh MC et al. Target ranges of oxygen saturation in extremely preterm infants. N Engl J Med. 2010; 362: 1959-1969.
13. Stenson B, Brocklehurst P, Tarnow-Mordi W. Increased 36-week survival with high oxygen saturation target in extremely preterm infants. N Engl J Med. 2011; 364: 1680-1682.
14. Saugstad OD, Aung D, Aguar M, et al. Optimalnie urovni frakcii kisloroda na nachalnom etape oKazaniia pomoshi v rodilnom zale nedonoshennim s gestacionnim vozrastom ≤32 nedel: sistematizirovannii obzor I metaanaliz [The Optimal levels of the fractions of oxygen at the initial stage of care in the delivery room premature infants with gestational age ≤32 weeks: a systematic review and meta-analysis]. Neonatologia: novosti, mnenie, obuchenie [Neonatology: news, opinion training]. 2014; 3 (5): 21-31.
15. Galie N, Hoeper M, Humbert M. Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J. 2009; 30 (20): 2493-2537.
16. Abman SH. Approach to the child with pulmonary hypertension and bronchopulmonary dysplasia. Advances Pulm Hypertens. 2011; 10 (2): 98-103.
17. Ovsyannikov DY, Zaitseva NO, Shokin AA, Degtyareva EA. Oslognenia bronholegochnoi displasii [Complications of bronchopulmonary dysplasia: pulmonary hypertension and cor pulmonale]. Neonatologia: novosti, mnenie, obuchenie. [Neonatology: news, opinion, training]. 2014; 2 (4): 38-48.
18. Allen J, Zwerdling R, Ehrenkranz R, et al. American Thoracic Society: Statement on the care of the child with
chronic lung disease of infancy and childhood. Am J Respir Crit Care Med. 2003;168: 356-396.
19. Schmidt B, Roberts RS, Davis P, et al. Caffeine for Apnea of Prematurity Trial Group: Caffeine therapy for apnea of prematurity. N Engl J Med. 2006; 354: 2112-2121.
20. Henderson-Smart DJ, Davis PG. Prophylactic methylxanthines for endotracheal extubation in preterm infants. Cochrane Database Syst Rev. 2010: CD000139.
21. Doyle LW, Ehrenkranz RA, Halliday HL. Corticosteroids in the early postnatal period (up to the 8th day of life) to prevent of bronchopulmonary dysplasia in premature infants. Cochrane Database Syst Rev. 2014; 5: CD001146.
22. Doyle LW, Ehrenkranz RA, Halliday HL. Later appointment (after the 7th day) of corticosteroids in bronchopulmonary dysplasia in premature infants. Cochrane Database Syst Rev. 2014; 5: CD001145.
23. Ehrenkranz RA, Halliday HL. Postnatal Hydrocortisone for Preventing or Treating bronchopulmonary Dysplasia in Preterm Infants: A Systematic Review. Neonatology. 2010; 98 (2): 111-117.
24. Ovsyanikov DY, Antonov AG, Ionov OV, et al. Proect protokola po diagnostike, profilaktike I lecheniiu broncholegochnoi displazii [The Draft Protocol on diagnosis, prevention and treatment of bronchopulmonary dysplasia]. Neonatologia: novosti, mnenie, obuchenie. [Neonatology: news, views, training]. 2014; 1 (3): 161-175.
25. Doyle LW, Davis PG, Morley CJ, et al. Low-Dose Dexamethasone Facilitates Extubation Among Chronically Ventilator-Dependent Infants: A Multicenter, International, Randomized, Controlled Trial. Pediatrics. 2006;117: 75-83.
26. Onland W, Offringa M, Jaegere AP De, van Kaam AH. Finding the Optimal Postnatal Dexamethasone Regimen for Preterm Infants at Risk of Bronchopulmonary Dysplasia: A Systematic Review of Placebo-Controlled Trials. Pediatrics. 2009;123 (1): 367-377.
27. Baibarina EN, Degtyarev DN ed. Izbrannie klinicheskie recomendacii po neonatologii [Selected clinical guidelines in neonatology]. M.: GEOTAR-Media. 2016: 198-199.
28. Ng GYT, da Silva O, Ohlsson A. Bronchodilation for the prevention and treatment of chronic lung disease in preterm infants. Cochrane Database Syst Rev. 2001; 23: CD003214.
29. Luca D De, Cogo P, Zecca E, et al. Intrapulmonary drug administration in neonatal and paediatric critical care: a comprehensive review. European Respiratory Journal. 2011; 37: 678-689.
30. Yuksel B, Greenough A, Maconachie I. Effective bronchodilator therapy by a simple spacer device for wheezy premature infants in the frst two years of life. Arch Dis Child. 1990; 65: 782-785.
31. Wilkie RA, Bryan MH. Effect of bronchodilators on airway resistance in ventilator-dependent neonates with chronic lung disease. J Pediatr. 1987; 111 (2): 278-82.
32. Volodin NN. Aktualnie problemi neonatologii [Actual problems of neonatology]. M: GEOTAR. 2004: 177-190.
33. Checchia PA, Nalysnyk L, Fernandes AW, et al. Mortality and and morbidity among infants at high risk for severe respiratory syncytial virus infection receving prophilaxis with palivizumab: A systematic literature review and meta-analysis. Pediatr Crit Care Med. 2011; 12 (5): 580-588.
CHRONIC KIDNEY DISEASE IN CHILDREN: ETIOLOGY, CLASSIFICATION AND PROGRESSION FACTORS
UDC 616.61-036.12-053.2(048.8)
DOI: 10.20969/VSKM.2016.9(2).36-41
DAMINOVA MARIA A., C. Med. Sci., assistant of professor of the Department of pediatrics and neonatology of Kazan State Medical Academy, Russia, 420012, Kazan, Mustari str., 11, tel. +7(843)562-52-66, e-mail: daminova-maria@yandex.ru
Abstract. Many diseases of childhood kidney continue to progress in adolescence and adulthood, leading to chronic kidney disease and its terminal stage. Aim. To study the modern data on etiology, classifcation, and factors of progression of chronic kidney disease in children. Material and methods. A review of literature on the problem of chronic diseases of the kidneys in children. Examined data on national and international research. Results and discussion. The defnition of chronic kidney disease stages and classifcation of children currently do not differ from those of adults. It is now known that the development of chronic kidney disease in children contribute to genetic, endogenous, demographics (gender, age) and a set of exogenous factors. An urgent problem is underdiagnosed. During the early stages of chronic kidney disease is variable and often unpredictable. Conclusion. Due to the fact that in childhood may reverse the development of chronic kidney damage and restore organ function, early detection, early treatment of kidney disease is an important prerequisite for the prevention or delay of its unfavorable outcome.
Key words: chronic kidney disease, children.
For reference: Daminova MA. Chronic kidney disease in children: etiology, classifcation and factors progression. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (2): 36—41.
References
1. K/DOQI: Klinicheskie prakticheskie rekomendacii po hronicheskomu zabolevaniyu pochek: ocenka, klassifkaciya i stratifkaciya [Clinical Practice Guidelines for chronic kidney disease: Evaluation, Classifcation and Stratifcation]. — URL: http://www.dialysis.ru/standard/ doqi-ckd/g7.htm
2. Hogg RJ, Furth S, Lemeley KV. National Kidney Foundation's Kidney Disease Outcomes Quality Initiative clinical practice guidelines for chronic kidney disease in children and' adolescents: evaluation, classifcation and stratis-faction. Pediatrics. 2003; 3 (6): 1416–1421.
3. Zemchenkov AJu, Tomilina NA. «K/DOQI» obrashhaetsja k istokam hronicheskoj pochechnoj nedostatochnosti [«K/DOQI» refers to the origins of chronic renal failure]. Nefrologija i dializ [Nephrology and dialysis]. 2004; 6 (3): 204–220.
4. Ignatova MS. Aktual'nye problemy nefrologii detskogo vozrasta v nachale XXI veka [Actual problems of pediatric nephrology at the beginning of the XXI century]. Pediatrija [Pediatrics]. 2007; 86 (6): 6–14.
5. ESPN/ERA-EDTA Registry (2010). ESPN/ERA-EDTA registry annual report 2008. URL: http://www.espn-reg. org/
6. Harambat J, van Stralen KJ, Kim JJ, Tizard EJ. Epidemiology of chronic kidney disease in children. Pediatr Nephrol. 2012; 27: 363–373.
7. Mak RH. Chronic kidney disease in children state of the art. Pediatr Nephrol. 2007; 22 (10): 1687-1688.
8. Smirnov AV, Shilov EM, Dobronravova VA [et al]. Nacional'nye rekomendacii: hronicheskaya bolezn' pochek: osnovnye principy skrininga, diagnostiki, profilaktiki i podhody k lecheniyu [National recommendations: chronic kidney disease: basic principles of screening, diagnosis, prevention and treatment approaches]. SPb: Levsha. 2013; 51 p.
9. Abdullina GA, Safna AI, Daminova MA. Klinicheskaja fziologija pochek u nedonoshennyh: rol' dinamicheskogo nabljudenija [Clinical renal physiology in premature: the role of dynamic observation]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Contemporary Clinical Medicine]. 2014; 7 (6): 9–13.
10. Safna AI. Kliniko-patogeneticheskaja rol' bakterial'nyh i virusnyh infekcij v razvitii i progressirovanii pielonefrita u detej [Clinical and pathogenetic role of bacterial and viral infections in the development and progression of pyelonephritis in children]. Nizhegorodskaja gosudarstvennaja medicinskaja akademija [Nizhny Novgorod State Medical Academy]. 2005; 47 p.
11. Safina AI, Daminova MA. Ostraja pochechnaja nedostatochnost' u novorozhdennyh. [Acute renal failure in newborns]. Prakticheskaja medicina [Practical Medicine]. 2011; 5 (53): 43–50.
12. Safina AI, Lutfullin IJa, Gajnullina JeA, Galeeva AV. Metabolicheskij sindrom u detej i podrostkov kak kompleksnyj faktor riska razvitija serdechno-sosudistyh zabolevanij [The metabolic syndrome in children and adolescents as a complex risk factor for cardiovascular disease]. Prakticheskaja medicina [Practical Medicine]. 2010; 5 (44): 61-65.
13. Vjalkova AA, Zorin IV, Gordienko LM [et al]. Voprosy diagnostiki hronicheskoj bolezni pochek u detej [Questions of chronic kidney disease diagnosis in children]. Prakticheskaja medicina [Practical Medicine]. 2013; 6 (75): 72–77.
14. Levey AS, de Jong PE, Сoresh J [et al]. The defnition, classifcation and prognosis of chronic kidney disease: a KDIGO Controversies Conference report. Kidney Int. 2010. URL: http:/www.kidney-international.org/
15. Lojmanna Je, Cygina AN, Sarkisjana AA red. Detskaja nefrologija: prakticheskoe rukovodstvo [Pediatric Nephrology: a practical guide]. M: Littera. 2010; 400 p.
16. Vjalkova AA. Sovremennye predstavlenija o tubulo-intersticial'nyh nefropatijah i koncepcija hronicheskoj bolezni pochek v pediatricheskoj nefrologii [Modern conceptions of tubulointerstitial nephropathy, and the concept of chronic kidney disease in the pediatric nephrology]. Pediatrija imeni GN Speranskogo [Pediatrics named GN Speransky]. 2008; 87 (3): 129–131.
17. Pecoraro С. Prevention of Chronic kidney disease (CKD) in children. Italian Journal of Pediatrics. 2015; 41 (Suppl 2): 56.
18. Mitsnefes M. Cardiovascular complications of pediatric chronic kidney disease. Pediatr Nephrol. 2008; 23: 27–39.
DIAGNOSTIC AND TREATMENT OF PROLONGED JAUNDICE IN YOUNG INFANTS
UDC 616.36-008.5-039.33-053.31(042.3)
DOI: 10.20969/VSKM.2016.9(2).42-46
VOLYANYUK ELENA V., C. Med. Sci., associate professor of the Department of pediatrics and neonatology of Kazan State Medical Academy, Russia, Kazan, Mushtari str., 11, tel. (843)562-52-66, e-mail: volanuk@mail.ru
Abstract. Prolonged jaundice in children of frst month’s age is widespread and indicates to examine the child and make decision for therapeutic interventions . Despite the fact that in most cases the jaundice is benign, it is necessary to exclude diseases manifestating with jaundice syndrome and expecting a poor prognosis. The aim of the article is analysis of the current literature data on the diagnosis, classifcation and treatment of prolonged jaundice in children. Material and methods. А review of domestic and foreign publications on the problem of jaundice in children during the frst months of life. Results and discussion. Presented diseases manifestating with a syndrome of prolonged jaundice, its differential diagnosis and therapeutic approaches. Conclusion. Modern diagnostics of jaundice in children during the frst months of life allows you to exclude a serious liver disease and to select the correct therapeutic tactics.
Key words: jaundice, cholestasis, indirect bilirubinemia.
For reference: Volyanyuk EV. Diagnostic and treatment prolonged jaundice in young infants. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (2): 42—46.
References
1. Kaganova TI, Loginova AA. Lechenie pri prolongirovannoj neonatal'noj zheltuhe [Treatment of prolonged neonatal jaundice]. Voprosy sovremennoj pediatrii [Problems of modern pediatry]. 2011; 10 (3): 10–14.
2. Shakirovа EM, Safna LZ, Shakirovа LZ et al. Struktura otsrochennyh prolongirovannyh zheltuh [Structure of deferred prolonged jaundice]. Prakticheskaja medicina [Practical medicine]. 2012; 7 (12): 41–45.
3. Volyanyuk EV, Kuznetsova AV. Taktika pediatra pri neonatal'noj zheltuhe [Tactics pediatrician with neonatal jaundice]. Prakticheskaja medicina [Practical medicine]. 2009; 7: 13–15.
4. Rula Harb, Danie Thomas. Conjugated Hyperbilirubinemia. Pediatrics in Review. 2007; 3: 23–58.
5. Academy of Breastfeeding Medicine. ABM Clinical Protocol #22: Guidelines for Management of Jaundice in the Breastfeeding Infant Equal to or Greater Than
35 Weeks’ Gestation. Breastfeeding medicine. 2010; 2: 87–92.
6. Volodin NN, Antonov AG, Aronskind EV et al. Protokol diagnostiki i lechenija giperbilirubinemii u novorozhdennyh detej [Minutes of the diagnosis and treatment of hyperbilirubinemia in newborns]. Voprosy prakticheskoj pediatrii [Questions of Practical Pediatrics]. 2006; 6: 9–18.
7. Gilmour SM. Prolonged neonatal jaundice: When to worry and what to do. Paediatr Child Health. 2004; 9: 70–74.
8. Delyagin VM, Вurkov SG. Semejnye formy funkcional'nyh giperbilirubinemij v rabote prakticheskogo vracha [Family form functional hyperbilirubinemia in the practitioner]. Lechashhij vrach [Attending doctor]. 1998; 2: 32– 39.
9. Bezerra JA, Balisteri WF. Cholestatic syndromes of infancy and childhood. Semin Gastrointest Dis. 2001; 12: 54–65.
10. Degtyarevа AV, Muhina YS, Volodin NN. Differencial'naja diagnostika i lechenie sindroma holestaza u novorozhdennyh detej (rekomendacii RASPM, proekt) [Differential diagnosis and treatment of the syndrome of cholestasis in newborns (recommendations RASPM project)]. Voprosy prakticheskoj pediatrii [Questions of Practical Pediatrics]. 2007; 2: 55–63.
11. Gilmour S, Hershkop M, Reifen R et al. Outcome of hepatobiliary scanning in neonatal hepatitis syndrome. J Nucl Med. 1997; 8: 79–82.
12. Mukhina JG, Belmer SV, Degtyareva AV et al. Holestaz i puti ego korrekcii v pediatricheskoj praktike: primenenie Ursofal'ka [Cholestasis and ways of its correction in pediatric patients: application Ursofalk]. Farmateka [Farmateka]. 2005; 1: 52–57.
RESPIRATORY MANIFESTATIONS OF GASTROESOPHAGEAL REFLUX IN CHILDREN
UDC 616.33-053.2-06(042.3)
DOI: 10.20969/VSKM.2016.9(2).46-52
ZAKIROV ILNUR I., C. Med. Sci., associate professor of the Department of pediatrics and neonatology of Kazan State Medical Academy, Russia, 420012, Kazan, Mushtari str., 11, tel. +7(843)562-52-66, e-mail: zakirov.ilnur@inbox.ru SAFINA ASIYA I., D. Med. Sci., professor, Head of the Department of pediatrics and neonatology of Kazan State Medical Academy, Russia, 420012, Kazan, Mushtari str., 11, tel. +7(843)562-52-66, e-mail: safina_asia@mail.ru
Abstract. Respiratory symptoms of gastroesophageal refux disease (GERD) undeservedly ignored by doctors of different specialties, but in the structure of the respiratory disease syndrome has a signifcant share. Aim — analysis of the current problem of diagnosis data, classifcation and treatment of extraesophageal manifestations of gastroesophageal refux disease. Material and methods. The review of domestic and foreign publications was performed. Results and discussion. Presented possible predisposing factors for the development of this disease in children of different ages, clinical manifestations, classifcation and treatment. Conclusion. One of the most signifcant extraesophageal manifestations of GERD in children is respiratory disorders in the form of a long nocturnal cough, recurrent bronchial obstruction syndrome, infammatory lesions of the lung parenchyma. Orientation of pediatricians on the problem of respiratory manifestations of gastroesophageal refux disease will improve the diagnosis of «unclear» respiratory illness and to select the optimal treatment regimen.
Key words: gastroesophageal refux disease, extraesophageal manifestations of respiratory disorders.
For reference: Zakirov II, Safna AI. Respiratory manifestations of gastroesophageal refux in children. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (2): 46—52.
References
1. Bryksina EJ, Pochivalov AV. Osobennosti techenija bronholegochnoj displazii na fone mikroaspiracii zheludochnogo soderzhimogo [Features of duration of bronchopulmonary dysplasia on the background of gastric contents microaspiration]. Nauchnye vedomosti [Scientifc Bulletin]. 2014; 18 (189): 119–123.
2. Burkov SG, Alekseeva EP, Arutyunov AG, Shipova TM. Vlijanie antisekretornoj terapii omeprazolom na nochnye simptomy bronhial'noj astmy pri ee sochetanii s GjeRB [Infuence of antisecretory therapy with omeprazole on nocturnal asthma symptoms when its combination with GERD]. Russkij zhurnal gastrojenterologii, gepatologii i koloproktologii [Russian journal of gastroenterology, Hepatology and Coloproctology]. 2008; 18 (4): 28–31.
3. Vasilyev YV. Bronhial'naja astm i gastrojezofagial'naja refjuksnaja bolezn' [Bronchial asthma and gastroesophageal reflux disease]. Mezhdunarodnyj medicinskij zhurnal [International medical journal]. 2004; 4: 15–20.
4. Gubergrits NB, Fomenko GP, Klochkov AY, Belyaeva NI. Gastrojezofagial'naja refjuksnaja bolezn' i bronhial'naja astma: kurica ili jajco? [Gastroesophageal refux disease and asthma: the chicken or the egg?]. Likars'kizasobi [Lcurses]. 2014; 4: 47–54.
5. Zhikhareva NS. Gastrojezofagial'naja refljuksnaja bolezn' u detej [Gastroesophageal refux disease in children]. Medicinskij sovet [Medical Council]. 2013; 3: 34–41.
6. Zverev SI, Eremina EY. Gastrojezofageal'naja refjuksnaja bolezn' [Gastroesophageal refux disease]. Medicinskij alfavit: Gastrojenterologija [Medical alphabet: Gastroenterology]. 2013; 2: 4–8.
7. Kagan YM, Khavkin AI, Mizernitsky YL. O vzaimosvjazi gastrojezofageal'noj refljuksnoj bolezni i bronhial'noj astmy u detej [On the relationship of gastroesophageal refux disease and bronchial asthma in children]. Detskaja gastrojenterologija [Pediatric gastroenterology]. 2005; 3: 20–21.
8. Ovsyannikov ES, Semenkova GG. Gastrojezofageal'naja refjuksnaja bolezn' kak prichina hronicheskogo kashlja [Gastroesophageal refux disease as a cause of chronic cough]. Consilium medicum. 2004; 6 (10): www. gastroscan.ru.
9. Blohin BM ed. Prakticheskoe rukovodstva po detskim boleznjam: zabolevanija organov dyhanija [Practical Handbook on children's diseases: diseases of the respiratory system]. M: Publishing house «Medical practice-M». 2007; 616 p.
10. Satybaeva RT. Svjaz' gastrojezofageal'nogo refjuksa s respiratornymi simptomami u detej [Relationship of gastroesophageal refux with respiratory symptoms in children]. Zdorov'e Kazahstana III tysjacheletija [the
Health of Kazakhstan of the third Millennium]. 2013; 5 (16): 6–7.
11. Tatochenko VK. Bolezni organov dyhanija u detej: prakticheskoe rukovodstva [Diseases of respiratory organs at children: practical manual]. M: «Pediatrician». 2012; 480 p.
12. Hodos EM, Krutko VS, Potato PI. Patofiziologija, vegetativnye narushenija i respiratornye maski GJeRB [Pathophysiology, vegetative disorders and respiratory masks GERD]. Novosti mediciny i farmacii [News of medicine and pharmacy]. 2011; 9 (364): 14 p.
13. Akinola E, Rosenkrantz TS, Pappagallo M et al. Gastroesophageal refux in infants < 32 weeks gestational age at birth: lack of relationship to chronic lung disease. Am J Perinatol. 2004; 21 (2): 57–62.
14. Fuloria M, Hiatt D, Dillard RG, O'Shea TM. Gastroesophageal refux in very low birth weight infants: association with chronic lung disease and outcomes through 1 year of age. J Perinatol. 2000; 20 (4): 235–239.
15. Krishnan U, Mitchell DJ, Messina I et al. Assay of tracheal pepsin as a marker of refux aspiration. J Pediatr Gastroenterol Nutr. 2002; 35 (3): 303–308.
16. Nelson SP, Chen EH, Syniar GM et al. Prevalence of Symptoms of Gastroesophageal Refux During In-fancy A Pediatric Practice–Based Survey. Arch Pediatr Adolesc Med. 1997; 151 (6): 569–572.
KAWASAKI SYNDROME: CLINICAL PATHWAYS AND THE PROBLEM OF UNDERDIAGNOSIS
UDC 616.13-002.1-053.2(042.3)
DOI: 10.20969/VSKM.2016.9(2).52-60
LUTFULLIN ILDUS YA., c. Med. Sci, associate professor of the Department of pediatrics and neonatology of Kazan State Medical Academy, Russia, 420012, Kazan, Mushtari str., 11, Head of the Department of pediatrics № 1 of city children's Hospital № 1 of Kazan, Russia, 420000, Kazan, Dekabrist str., 125a, e-mail: lutfullin@list.ru
Abstract. Kawasaki syndrome is a systemic vasculitis, characterized by lesions of arteries of small and medium caliber, with a clinical picture that includes a variety of symptoms. Aim — analysis of modern data on epidemiology, pathogenesis, diagnosis and treatment of Kawasaki syndrome. Material and methods. Domestic and foreign publications were reviewed; the results of major epidemiological studies on the problem of Kawasaki syndrome examined. Results and discussion. Presented modern diagnostic algorithms, treatment of disease and follow-up, as well as to focus attention on the problem of underdiagnosis. Conclusion. Application of modern diagnostic algorithms and treatment of Kawasaki syndrome in clinical practice will solve the problem of underdiagnosis of the disease, risk of developing coronary complications. An example of a late clinical diagnosed case of Kawasaki syndrome with a positive outcome as a result of adequate therapy is given.
Key words: Kawasaki syndrome, underdiagnosis, clinical example.
For reference: Lutfullin IYа. Kawasaki syndrome: clinical pathways and the problem of underdiagnosis. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (2): 52—60.
References
1. Newburger JW, Takahashi M, Gerber MA, Gewitz MH, Tani LY, Burns JC, Shulman ST, Bolger AF, Ferrieri P, Baltimore RS, Wilson WR, Baddour LM, Levison ME, Pallasch TJ, Falace DA, Taubert KA; Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Diagnosis, treatment, and long–term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Pediatrics. 2004; 6: 1708–1733.
2. JCS Joint Working Group. Guidelines for diagnosis and management of cardiovascular sequelae in Kawasaki disease (JCS 2008) digest version. Circ J. 2010; 9: 1989–2020.
3. Research Committee of the Japanese Society of Pediatric Cardiology; Cardiac Surgery Committee for Development
of Guidelines for Medical Treatment of Acute Kawasaki Disease. Guidelines for medical treatment of acute Kawasaki disease: report of the Research Committee of the Japanese Society of Pediatric Cardiology and Cardiac Surgery (2012 revised version). Pediatr Int. 2014; 2: 135–158.
4. Lyskina GA, Vinogradova OI, Shirinskaja OG et al. Klinika, diagnostika i lechenie sindroma Kavasaki: rossijskie klinicheskie rekomendacii [The clinic, diagnosis and treatment of Kawasaki syndrome: Russian clinical guidelines]. URL: http://www.cardio–rus.ru/doc/kawasaki. pdf.
5. Bregel' LV, Belozerov JuM, Subbotin VM. Bolezn' Kavasaki u detej — pervye klinicheskie nabljudenija v Rossii [Kawasaki disease in children — the frst clinical observations in Russia]. Rossijskij vestnik perinatologii i pediatrii [Russian messenger of perinatology and pediatrics.]. 1998; 4: 25–30.
6. Bregel' LV, Belozerov JuM, Subbotin VM. Porazhenie serdca pri bolezni Kavasaki u detej [The heart lesions in Kawasaki disease in children]. Rossijskij vestnik perinatologii i pediatrii [Russian messenger of perinatology and pediatrics]. 1998; 5: 22–35.
7. Lyskina GA, Shirinskaja OG. Slizisto-kozhnyj limfo-noduljarnyj sindrom (sindrom Kavasaki): Diagnostika i lechenie. [Limfonodulyarny mucocutaneous syndrome (Kawasaki syndrome): Diagnosis and treatment]. Moscow: Vidar–M. 2008: 128 p.
8. Park YW. Epidemiology of Kawasaki disease in Korea. Korean J Pediatr. 2008; 5: 452–456.
9. Lyskina GA, Tobrjak AV. Sindrom Kavasaki u detej, zabolevshih v vozraste 5 let i starshe: Obzor literatury, sobstvennoe nabljudenie [Kawasaki syndrome in children infected at age 5 and older: Review of the literature, own observation]. DoktorRu [DoktorRu]. 2015; 13: 39–42.
10. Singh S, Vignesh P, Burgner D. The epidemiology of Kawasaki disease: a global update. Arch Dis Child. 2015; 11: 1084–1088.
11. Reddy M, Singh S, Rawat A, Sharma A, Suri D, Rohit MK. Pro–brain natriuretic peptide (ProBNP) levels in North Indian children with Kawasaki disease. Rheumatol Int. 2016; 5: [Epub ahead of print].
12. Behtereva MK. Sindrom Kavasaki v praktike pediatra i infekcionista [Kawasaki syndrome in pediatric and infectious disease practice]. Kliniko-laboratornyj konsilium [Clinical and laboratory consultation]. 2013; 1: 43– 49.
13. Maddox RA, Holman RC, Uehara R, Callinan LS, Guest JL, Schonberger LB, Nakamura Y, Yashiro M, Belay ED. Recurrent Kawasaki disease: USA and Japan. Pediatr Int. 2015; 6: 1116–1120.
14. Oates–Whitehead RM, Baumer JH, Haines L et al. Intravenous immunoglobulin for the treatment of Kawasaki disease in children. Cochrane Database Syst Rev. 2003; CD004000.
15. Helen Foster, Paul A Brogan ed. Oxford specialist Handbooks in Paediatrics: Paediatric Rheumatology. Oxford UK: Oxford University press. 2012; 240 p.
16. Millar K, Manlhiot C, Yeung RS, Somji Z, McCrindle BW. Corticosteroid administration for patients with coronary artery aneurysms after Kawasaki disease may be associated with impaired regression. Int J Cardiol. 2012; 1: 9–13.
17. Eleftheriou D, Levin M, Shingadia D, Tulloh R, Klein NJ, Brogan PA. Management of Kawasaki disease. Arch Dis Child. 2014; 1: 74–83.
NEW VITAMIN D SUPPLY INDICATORS IN CHILDREN AND CORRECTION OF ITS DEFICIENCY
UDC 616.391-053.3:577.161.2
DOI: 10.20969/VSKM.2016.9(2).61-64
MALTSEV STANISLAV V., D. Med. Sci., professor of the Department of propedeutics of children's diseases, faculty pediatrics with the course of children diseases of Kazan State Medical university, Russia, 420012, Kazan, Butlerov str., 49, e-mail: maltc@mail.ru
ZAKIROVA ALFIYA M., C. Med. Sci., associate professor of the Department of propedeutics of children's diseases, faculty pediatrics with the course of children diseases of Kazan State Medical university, Russia, 420012, Kazan, Butlerov str., 49
MANSUROVA GUZEL SH., C. Med. Sci., associate professor of the Department of emergency medicine and simulation medicine of Kazan federal university, Russia, 420008, Kazan, Kremlevskaya str., 18
Abstract. Aim. Assesment of the status of vitamin D supply of frst year life children, depending of the impact of insolation, seasonality, period of birth, dotation of vitamin D drug in the frst months of life, type of feeding, and preventive reception of vitamin by mother during pregnancy and breastfeeding. Material and methods. Patients took part in research were 114 children aged 0 to 12 months, 62 from them were left without parental care (group 1), 52 from them were home children (group 2). All children underwent the determination of 25-hydroxycholecalciferol (25(OH)D) in serum. Levels of 30—80 ng/ml were recognized as normal range of concentrations of 25(OH)D, levels of 20—30 ng/ml recognized as borderline insuffciency, levels of 10—20 ng/ml — as defciency, levels less than 10 ng/ml — as severe defciency. The study of clinical and anamnestic data of mother-child pairs using mother questioning and children`s development patient charts were performed. Results and discussion. The results of the study indicated the low vitamin D supply even in frst year life children, who originally were not in high risk group due to preventive administration of vitamin D in autumn-winter period. Moreover, the minimal supply were noticed among breastfed children, among mothers who did not receive dotation of vitamin D and adequate insolation in the third trimester of pregnancy. Conclusion. Children of frst year of life, breastfed, born in the autumn-winter period and without adequate insolation were at risk group for vitamin D hypovitaminosis and they should be provided with a higher prophylactic dose of vitamin D during all the year.
Key words: vitamin D, infants, supply, dosage.
For reference: Maltsev SV, Zakirova AM, Mansurova GS. New vitamin D supply indicators in children and correction of its defciency. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (2): 61—64.
References
1. Holick MF et al. Evaluation, Treatment, and Prevention of Vitamin D Defciency: an Endocrine Society Clinical Practice Guideline Journal of Clinical Endocrinology & Metabolism. 2011; 96 (7): 1911–1930.
2. Gromova OA, Torshin IJu. Vitamin D — smena paradigmy [Vitamin D — a paradigm shift]. M: TORUS PRESS. 2015; 464 p.
3. Gupta V. Vitamin D: Extra–skeletal effects. J Med Nutr Nutraceut. 2012; 1: 17–26.
4. Baeke F, Takiishi T, Korf H, Gysemans C, Mathieu C. Vitamin D: modulator of the immune system. Curr Opin Pharmacol. 2010; 10 (Issue 40): 482–496.
5. Wacker M, Holick MF. Vitamin D–effects on skeletal and extra skeletal health and the need for supplementation. Nutrients. 2013; 5 (1): 111–148.
6. Nacional'naja programma «Nedostatochnost' vitamina D u detej i podrostkov v Rossijskoj Federacii: sovremennye podhody k korrekcii» [National program «Vitamin D defciency in children and adolescents in the Russian Federation: modern approaches to correction»]. М. 2015; 112 p.
7. Holick MF. High prevalence of vitamin D inadecuacy fnd implications for health. Mayo Clin Proc. 2006; 81: 353–373.
8. Zaharova IN, Gromova OA. Chto nuzhno znat' pediatru o vitamine D: Novye dannye o diagnostike i korrekcii ego nedostatochnosti v organizme [What pediatrician needs to know about vitamin D: New data on the diagnosis and correction of its defciency in the body]. Pediatria [Pediatrics]. 201; 94 (6): 1–7.
9. Shin JS, Choi MY, Longtine MS, Nelson DM. Vitamin D effects on pregnancy and the placenta. Placenta. 2010; 31 (Issue 12): 1027–1034.
10. Thandrayen K, Pettifor JM. Maternal Vitamin D Status: Implications for the Development of Infantile Nutritional Rickets. Endocrinology and Metabolism Clinics of North America. 2010; 39 (Issue 2): 303–320.
11. Mal'cev SV, Spirichev VB, Shakirova JeM. Rol' defcita vitamina D v razvitii rahita u detej rannego vozrasta [The role of vitamin D defciency in the development of rickets in infants]. Voprosy ohrany materinstva i detstva [Issues of maternal and child health]. 1987; 6: 35– 38.
12. Gromova OA, Torshin IJu, Zaharova IN. O dozirovanii vitamina D u detej i podrostkov [About vitamin D dosing in children and adolescents]. Voprosy sovremennoj pediatrii [Current Pediatrics]. 2015; 14 (1): 38–47.
13. Mal'cev SV, Arhipova NN, Shakirova JeM. Vitamin D, kal'cij i fosfaty u zdorovyh detej i pri patologii [Vitamin D, calcium and phosphate in healthy children and pathology]. Kazan. 2012; 120 p.
14. Reusheva SV, Panicheva EA, Pastuhova SJu, Reushe MJu. Znachenie defcita vitamina D v razvitii zabolevanij cheloveka [The value of vitamin D deficiency in the development of human diseases]. Uspehi sovremennogo estestvoznanija [The success of modern science]. 2013; 11: 27–31.
15. Natarajan CR, Sankar MJ, Agarwal R, Pratar OT, Jain V, Gupta N, Gupta AK, Deorari AK, Paul VK, Sreenivas V. Trial of daily vitamin D supplemention in preterm infants. Pediatrics. 2014; 133 (3): 628–634.
THE ROLE OF PERINATAL INJURIES OF THE NERVOUS SYSTEM IN THE FORMATION OF NEUROLOGICAL DISORDERS OF CHILDHOOD
UDC 616.831-053.2(042.3)
DOI: 10.20969/VSKM.2016.9(2).65-70
PRUSAKOV VLADIMIR F., D. Med. Sci., professor, Head of the Department of children's neurology of Kazan State Medical Academy, Russia, 420061, Kazan, Mushtari str., 11, tel. (843) 273-49-09, e-mail: kaz.dnevr@mail.ru
MOROZOVA ELENA A., D. Med. Sci., professor of the Department of children's neurology of Kazan State Medical Academy, Russia, 420061, Kazan, Mushtari str., 11, tel. (843) 273-49-09, e-mail: ratner@bk.ru
MARULINA VALENTINA I., C. Med. Sci., associate professor of the Department of children's neurology of Kazan State Medical Academy, Russia, 420061, Kazan, Mushtari str., 11, tel. (843) 273-49-09, e-mail: marulina_vi@mail.ru
BELOUSOVA MARINA V., C. Med. Sci., associate professor of the Department of children's neurology of Kazan State Medical Academy, Russia, 420061, Kazan, Mushtari str., 11, tel. (843) 273-49-09, e-mail: belousova.marina@mail.ru
UTCUSOVA MARINA A., C. Med. Sci., associate professor of the Department of children's neurology of Kazan State Medical Academy, Russia, 420061, Kazan, Mushtari str., 11, tel. (843) 273-49-09, e-mail: utkuzova.marina@gmail.com
GAMIROVA RIMMA G., C. Med. Sci., associate professor of the Department of children's neurology of Kazan State Medical Academy, Russia, Kazan, Mushtari str., 11, tel. (843) 273-49-09, e-mail: r-gamirov@mail.ru
KNYAZEVA OLESYA V., C. Med. Sci., assistant of professor of the Department of children's neurology of Kazan State Medical Academy, Russia, 420061, Kazan, Mushtari str., 11, tel. (843) 273-49-09, e-mail: knyazeva.dnevr@mail.ru
MOROZOV DMITRY V., assistant of professor of the Department of children's neurology of Kazan State Medical Academy, Russia, 420061, Kazan, Mushtari str., 11, tel. (843) 273-49-09, e-mail: kiverkot@mail.ru
ZAIKOVA FANYA M., C. Med. Sci., assistant of professor of the Department of children's neurology of Kazan State Medical Academy, Russia, 420061, Kazan, Mushtari str., 11, tel. (843) 273-49-09, e-mail: detbol8@mail.ru
Abstract. Neurological disorders of childhood, associated with perinatal pathology of the brain, require an algorithm of phased observation and treatment of the patient from the frst hours after birth and in subsequent periods of growth and development. Aim. Analysis of modern data on a problem of diagnostics, classifcation and treatment of perinatal damages of the central nervous system. Material and methods. Presented modern classifcation and methods of diagnosis of brain lesions, paroxysmal conditions with own research results. Results and discussion. Methods of early diagnosis and rehabilitation of children with perinatal pathology, paroxysmal conditions were proposed. Conclusion. Modern methods of diagnostics and therapy of perinatal defeats of nervous system in clinical practice will allow to achieve good clinical results and to reduce risk of development of long-term outcome.
Key words: perinatal pathology of the brain, the algorithm of observation, treatment, long-term consequences.
For reference: Prusakov VF, Morozova EA, Marulina VI, Belousova MV, Utcusova MA, Gamirova RG, Knyazeva OV, Morozov DV, Zaikova FM. The role of perinatal injuries of the nervous system in the formation of neurological disorders of childhood. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (2): 65—70.
References
1. Barashnev JuI. Perinatal'naja nevrologija [Perinatal neurology]. M: Triada-H [M: Triada-H]. 2011; 640 p.
2. Prusakov VF, Morozova EA, Belousova MV et al. Sovremennye problemy perinatal'noj nevrologii [Modern problems of perinatal neurology] Prakticheskaja medicina [Applied medicine]. 2012; 2: 57-60.
3. Ratner AYu. Nevrologija novorojdennyh (ostryj period i pozdnie oslojnenija) [Nevrologiya of newborns (sharp period and late complications)]. Kazan': Izd-vo Kazan. un-ta [publishing house of the Kazan state university]. 1995; 367 p.
4. Chutko LS, Livinskaja AM. Specifcheskie rasstrojstva rechevogo razvitija u detej [Specifc disorders of speech development in children]: uchebno-metodicheskoe posobie [educational — methodical manual]. St Petersburg: IPK BIONT. 2006; 48 p.
5. Stasevich SM. Medicinskie i social'nye aspekty, obuslovlivajushhie razvitie perinatal'noj patologii CNS [The medical and social aspects causing development of perinatal pathology of the central nervous system]. Reproduktivnoe zdorov'e: Vostochnaja Evropa [Reproductive health: Eastern Europe]. 2014; 4 (34): 123 p.
6. Bryksina EJu. Patogeneticheskie aspekty perinatal'nogo porazhenija central'noj nervnoj sistemy i osobennosti nevrologicheskogo statusa nedonoshennyh detei [Pathogenetic aspects of perinatal defeat of the central nervous system and feature of the neurologic status of prematurely born children]. Sovremennye problemy nauki i obrazovanija [Modern problems of science and education]. 2015; 4: 410 p.
7. Guzeva VI. Rukovodstvo po detskoj nevrologii [Guide to children's neurology]. M: Medicinskoe informacionnoe agentstvo [Medical news agency]. 2009; 640 p.
8. Volodin NN, Medvedev MI, Gorbunov AV. Rannjaja diagnostika neblagoprijatnyh posledstvij perinatal'nyh gipoksicheski-ishemicheskih porajenij golovnogo mozga u nedono6ennyh detej i optimizacija ih lechenija [Early diagnostics of adverse effects perinatal hypoxemic — ischemic damages of a brain at prematurely born children and optimization of their treatment]. Pediatrija [Pediatrics]. 2010; 2: 101-107.
9. Baranov AA, Albitsky VJ. Mladen4eskaja smertnost': uroki istorii i perspektivy snizhenija [Mladencheskaya mortality: lessons of history and prospect of decrease]. Kazanskij medicinskij zhurnal [Kazan Medical Journal]. 2011; 5: 690-694.
10. Karlov VA. Jepilepsija u detej i vzroslyh zhenschin i muzhchin [Epilepsiya at children and adult women and men] M: Medicina [M: Medicine]. 2010; 720 p.
11. Cvitanović-Sojat L. Treatment of West syndrome. Acta Med Croatica. 2005; 59 (1): 19 p.
12. Malinovskaja OS, Belousova ED, Keshishyan ES. Faktory riska i prognoz detskogo cerebral'nogo paralicha i jepilepticheskih sindromov u nedono6ennyh detej s perivntrikuljarnoj lejkomaljaciej [Risk factors and the forecast of a children's cerebral palsy and epileptic syndromes at prematurely born children with a perivntrikulyarny leykomalyation]. Rossijskij vestnik perinatalogii i pediatrii [Russian messenger of perinatology and pediatrics]. 2005; 3: 30-35.
13. Aljamovskaja GA. Osobennosti fzi4eskogo razvitija na pervom godu zhizni detej s massoj tela pri rozhdenii menee 1500 g [Features of physical development on the frst year of life of children with body weight at the birth less than 1500 g]. Rossijskij vestnik perinatologii i pediatrii [Russian messenger of perinatology and pediatrics]. 2009; 3: 20-28.
14. Ratner FL, Utkuzova MA. Koncepcija reabilitacii razvitija detej Teodora Hell'brjugge [Concept of rehabilitation of development of children of Theodor Hellbryugge]: metodicheskie rekomendacii [methodical recommendations]. Kazan': Centr innovacionnyh tehnologij [Kazan: Center of innovative technologies]. 2004; 34 p.
15. Hellbryugge T. Mjunhenskaja funkcional'naja diagnostika razvitija: pervye tri goda zhizni; Scientifc edition, translation Ratner FL, Utkuzova MA [Munich functional diagnostics of development: frst three years of life]. Kazan': Centr
innovacionnyh tehnologij [Kazan: Center of innovative technologies]. 2004; 287 p.
16. Vojta V. Das Vojta-Prinzip Aufage. Springer Heidelberg. 2007; 3: 230 p.
17. Fatyhova NR, Gamirova RG, Ziganshin LE. Glubokonedono6ennye deti i sindrom Vesta [Deep-prematurely born children and Vest's syndrome]. Kazanskij medicinskij zhurnal [Kazan Medical Journal]. 2014; 96 (1): 11-18.
18. Morozova EA. Nevrologicheskie narushenija u podrostkov kak sledstvie perinatal'noj patologii CNS [Neurologic violations at teenagers as a result of perinatal pathology of the central nervous system]. Russkij medicinskij zhurnal [Russian medical magazine]. 2008; 16 (3): 126-129.
UDC 616.3-008.1-053.36(042.3)
DOI: 10.20969/VSKM.2016.9(2).70-76
RYBKINA NADEZHDA L., C. Med. Sci., associate professor of the Department of pediatrics and neonatology of Kazan State Medical Academy, neonatologist of republican clinical Hospital, Russia, 420012, Kazan, Mushtari str., 11, tel. 8-927-434-56-64, e-mail: natasha160899@yandex.ru
Abstract. Functional disorders of the digestive system are diagnosed in the absence of organic lesions of the digestive system. Aim. To study the current data of etiology, pathogenesis and methods of correction of functional digestive disorders in infants. Material and methods. A review of literature on functional disorders in infants was performed using data of national and international researches. Results and discussion. Provided the classifcation of functional disorders, discussed the etiological factors that lead to the formation of the main clinical manifestations of functional disorders in children. Discussed the problems associated with questions of diagnostics of functional digestive disorders. Treatment of functional disorders of the digestive system in children described out in several stages from the point of view of evidence-based medicine. Recommendations for parents counseling are given. Modern approaches to the prevention of common functional digestive disorders like regurgitation syndrome, colic syndrome and constipation in children under one year were demostrated. Conclusion. Functional disorders of the digestive system often diagnosed in young children. Despite the absence of organic lesions, in the absence of a timely correction of functional disorders of the digestive system can lead to the formation of diseases in older age.
Key words: functional disorders of the digestive system, intestinal colic, regurgitation syndrome, the child frst year of life.
For reference: Rybkina NL. Functional disoders of the digestive system in children under one year: clinical manifestations, modern approaches to correction. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (2): 70—76.
References
1. Bogdanova NM. Funkcional'nye narushenija pishhevarenija u mladencev: prichiny vozniknovenija, otdalennye posledstvija i vozmozhnosti dietoterapii [Functional digestive disorders in infants: causes, possible long-term implications and diet therapy]. Consilium Medicum. 2013; 2: 7–10.
2. Ursova NI. Narushenija funkcii zheludochno–kishechnogo trakta u detej rannego vozrasta: problema, analiz obobshhennyh dannyh [Disorders of the gastrointestinal tract in infants: the problems, the analysis of summarized data]. Voprosy sovremennoj pediatrii [Questions of modern pediatrics]. 2009; 8 (6): 48–54.
3. Bel'mer SV, Gasilina TV, Havkin AI, Jejberman AS. Funkcional'nye narushenija organov pishhevarenija u detej: rekomendacii i kommentarii [Functional disorders of the digestive system in children: recommendations and comments].Moskva [Moscow]. 2006; 44 p.
4. Keshishjan ES. Kishechnye koliki i korrekcija mikrobnoj kolonizacii u detej pervyh mesjacev zhizni: klinika, differencial'naja diagnostika, podhody k terapii. IInformacija dlja vrachej [Intestinal colic and correction of microbial colonization in children during the frst months of life: clinic, differential diagnosis, approaches to therapy. Information for physicians]. Moskva [Moscow]. 2006; 48 p.
5. Muhina JuG, Chubarova AI, Geras'kina VP. Sovremennye aspekty problemy laktaznoj nedostatochnosti u detej rannego vozrasta [Modern aspects of lactase defciency in infants]. Voprosy detskoj dietologii [ Questions of children's nutrition]. 2003; 2 (1): 50–54.
6. Goncharova OV. Kak sohranit' grudnoe vskarmlivanie, perevesti rebenka na smeshannoe / iskusstvennoe vskarmlivanie ili otluchit' ot grudi [How to keep breastfeeding , transfer the child to a mixed / or artifcial feeding]. Consilium Medicum Pediatrija. 2012; 2: 15–19.
7. Nacional'naja programma optimizacii vskarmlivanija detej pervogo goda zhizni v Rossijskoj Federacii [The national program to optimize feeding infants during the frst year of life in the Russian Federation]. Moskva [Moscow]. 2010; 67 p.
8. Mel'nikova IJu, Novikova VP, Dumova NB. Zapory u detej [Constipation in children]. M: GJeOTAR–Media [GEOTAR Media]. 2009; 144 р.
9. Jacyk GV, Beljaeva IA. Metodologicheskie aspekty diagnostiki i lechenija sindroma srygivanija i rvot (SRS) [ Methodological aspects of diagnosis and treatment of the syndrome of regurgitation and vomiting]. Moskva [Moscow]. 2003; 16 р.
10. Havkin AI. Funkcional'nye narushenija ZhKT u detej rannego vozrasta; Laktaznaja nedostatochnost': Posobie dlja vrachej [Functional disorders of the gastrointestinal tract in infants; Lactase defciency: Manual for physicians]. Moskva [Moscow].2007; 24 р.
11. Volodin NN ed. Neonatologija: nacional'noe rukovodstvo [Neonatology: national guideline]. M: GJeOTAR– Media[GEOTAR Media]. 2007; 848 р.
12. Osnovy uhoda za novorozhdennymi i grudnoe vskarmlivanie [Fundamentals of newborn care and breastfeeding]. Evropejskoe regional'noe bjuro VOZ [Europe Regional Offce of The World Health Organization]. 2002; 173 р.
13. Kornienko EA, Mazankova LN, Gorelov AV. Primenenie probiotikov v pediatrii: analiz lechebnogo i proflakticheskogo dejstvija s pozicij dokazatel'noj mediciny [The use of probiotics in pediatrics: analysis of therapeutic and preventive actions from the viewpoint of evidence-based medicine]. Lechashhij vrach [The attending physician]. 2015; 9: 52–61.
14. Zaharova IN, Jacyk GV, Borovik TJe. Mladencheskie kishechnye koliki: sovremennyj vzgljad na problemu [Infant intestinal colic: a modern view on the problem]. Consilium medicum. 2014; 4: 46–53.
15. Beljaeva IA, Namazova-Baranova LS, Potehina TV. Mladencheskie koliki– novyj vzgljad na staruju problemy [Infant colic — a new look at an old problem]. Pediatrija [Pediatrics]. 2015; 1: 137–144.
16. Netrebenko OK, Kornienko EA, Kubalova SS. Ispol'zovanie probiotikov u detej u detej s mladencheskimi kishechnymi kolikami [The use of probiotics in children in children with infant intestinal colic]. Pediatrija [Pediatrics]. 2014; 4: 86–93.
17. Livshic KH. Rol' kishechnoj mikrobioty i probiotikov v pediatrii [The role of the intestinal microbiota and probiotics in pediatrics].Vestnik sovremennoj klinicheskoj mediciny [Journal of Contemporary Clinical Medicine]. 2013; 6 (1): 41–44.
18. Kalmykova AS ed. Poliklinicheskaja pediatrija [Рolyclinical pediatrics]. M:GJeOTAR-Media [GEOTAR-Media]. 2007; 624 р.
19. Wake M, Morton-Allen E, Poulakis Z, Hiscock H, Gallagher S, Oberklaid F. Prevalence, stability, and outcomes of cry-fuss and sleep problems in the frst 2 years of life: prospective community-based study. Pediatrics. 2006; 117 (3): 836–842.
20. Wolke D, Rizzo P, Woods S. Persistent infant crying and hyperactivity problems in middle childhood. Pediatrics. 2002; 109 (6): 1054–1060.
MODERN APPROACHES TO NUTRITION OF CHILDREN FROM 1 YEAR TO 3 YEARS
UDC 613.22(042.3)
DOI: 10.20969/VSKM.2016.9(2).77-85
SAFINA ASIYA I., D. Med. Sci., professor, Head of the Department of pediatrics and neonatology of Kazan State Medical Academy, Russia, 420012, Kazan, Mushtari str., 11, tel. +7-843-562-52-66, e-mail: safina_asia@mail.ru
Abstract. Aim. To provide information on the principles and methods of children from 1 year to 3 years nutrition organizing, to present normal ranges of physiological requirements of energy and nutrients. Material and methods. This article was prepared on the basis of the National Programme for optimizing nutritional status of children 1-3 years in the Russian Federation (2016). Results and discussion. The characteristic of the diet and the individual product groups, as well as methods for their cooking, taking into account the age of children demonstrated. The basic principles of drawing up of the individual child's diet from 1 to 3 years showed. An indicative menu of children from 1 year to 3 years presented. Conclusion. Organization of children nutrition at an early age makes it possible to form a correct taste habits, create a rational eating pattern of the child, to ensure its harmonious growth, the timely development of internal organs and tissues, the formation of intellectual and psychomotor status, as well as on health later in life. Key words: nutrition, child, from one year to three years.
For reference: Safna AI. Modern approach to nutrition of children from 1 year to 3 years. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (2): 77—85.
References
1. Sojuz pediatrov Rossii [Union of pediatricians of Russia] et al. Nacional'naja programma optimizacii pitanija detej v vozraste ot 1 goda do 3 let v Rossijskoj Federacii [The national program to optimize nutritional status of children aged 1 to 3 years in the Russian Federation]. M: Pediatr [Pediatrition]. 2015; 36 p.
2. Tutel'jana VA, Konja IJa, Kaganova BS ed. Pitanie zdorovogo i bol'nogo rebenka: posobie dlja vrachej [Nutrition of a healthy and a sick child: A Handbook for Physicians]. M: Dinastija [Dynasty]. 2010; 4: 51-62.
3. Kon' IJa, Bulatova EM, Abramova TV, Kurkova VI. Kashi v pitanii detej rannego vozrasta: posobie dlja vrachej [Porridgs in the nutrition of young children: A guide for physicians]. Sankt-Petersburg: GU NII pitanija RAMN [St. Petersburg Research Institute of Nutrition]. 2006; 19 p.
4. Organizacija detskogo pitanija: Sanitarno-jepide-miologicheskie pravila i normativy (SanPiN 2.3.2.1940–05) [The baby food: sanitary-epidemiological rules and norms]. 2005; 17 p. Access: http://20.rospotrebnadzor.ru/fles/docs/ instruction/156.pdf
5. Normy fziologicheskih potrebnostej v jenergii i pishhevyh veshhestvah dlja razlichnyh grupp naselenija Rossijskoj Federacii MR 2.3.1.2432-08 [Norms of physiological needs for energy and nutrients for different groups of the population of the Russian Federation]. 2008; Access: http:// docs.cntd.ru/document/1200076084
6. Zaharova IN, Borovik TJe, Surzhik AV, Dmitrieva JuA. Osobennosti pitanija detej ot goda do treh let: uchebnoe posobie dlja vrachej [Feeding habits of children from one to three years: a manual for physicians]. M: RMAPO. 2012; 60 p.
7. Borovik TJe, Ladodo KS ed. Klinicheskaja dietologija detskogo vozrasta: rukovodstvo dlja vrachej [Clinical Nutrition Childhood: A Guide for Physicians]. M: «Medicinskoe informacionnoe agentstvo» [Moscow: «Medical News Agency»]. 2008; 608 p.
UDC 616-053.32-085.272.2(042.3)
DOI: 10.20969/VSKM.2016.9(2).85-92
STEPANOVA OLGA A., C. Med. Sci., associate professor of the Department of pediatrics and neonatology of Kazan State Medical Academy, Russia, 420012, Kazan, Mushtari str., tel. (843) 562-52-66, e-mail: kafped@yandex.ru
Abstract. Preterm infants, especially born with very low and extremely low body weight, are the most complex and vulnerable patients in modern neonatology. The immaturity of organs and systems, regulating water-electrolyte metabolism dictates the need to fnd adequate methods for maintaining fuid and electrolyte balance during intensive care these patients. The aim of the article was to analyze the current data about the features of fuid and electrolyte metabolism and correction of its disorders in very preterm infants with very low and extremely low birth weight. Material and methods. A review of domestic and foreign publications, data from randomized clinical trials and regulations of clinical protocols and guidelines. Results and its discussion. Current data was described about the features of the fuid and electrolytes metabolism, as well as modern principles of diagnosis and correction of these components of homeostasis in preterm infants. Conclusion. Using evidence-based medicine recommendations during prescribing infusion therapy in preterm infants can not only stabilize their condition, but also to improve long-term outcomes and prevent complications such as bronchopulmonary dysplasia, neurological and metabolic disorders.
Key words: preterm infants, fuid and electrolyte balance.
For reference: Stepanova OA. Maintenance of fuid and electrolyte balance in preterm infants with very low and extremely low birth weight. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (2): 85—92.
References
1. Baibarina EN, Degtyarev DN. Perehod na novye pravila registracii rozhdenija detej v sootvetstvii s kriterijami, rekomendovannymi Vsemirnoj organizaciej zdravoohranenija: istoricheskie, mediko-jekonomicheskie i organizacionnye aspekty [Transition to new rules for baby’s birth registration in accordance with the criteria recommended by the world health organization: historical, medico–economic, and organizational aspects]. Rossijskij vestnik perinatologii i pediatrii [Russian Bulletin Perinatology and Pediatrics]. 2011; 6: 6–9.
2. Hartnoll G, Betremieux P, Modi N. Body water content of extremely preterm infants at birth. Arch Dis Child Fetal Neonatal Ed. 2000; 83 (1): 56–59.
3. Ivanov DO, Surkov DN, Mavropulo TK. Vodno-jelektrolitnye i jendokrinnye narushenija u detej rannego vozrasta [Water and electrolyte and endocrine disorders in infants]. SPb: Inform–Navigator. 2013; 920 p.
4. Modi N. Management of fuid balance in very premature neonate. Arch Dis Child Fetal Neonatal Ed. 2004; 89: 108–111.
5. MacDonald MG, Seshia MK, Mullett MD. Avery's Neonatology, 6th Edition. 2005; 1710 р.
6. Volodin NN ed. Neonatologija: nacional'noe rukovodstvo [Neonatology: national guideline]. M: GJeOTAR–Media. 2007; 848 p.
7. Aleksandrovich JuS, Pshenisnov KV. Intensivnaja terapija novorozhdennyh [Newborn Intensive Therapy]. SPb: Izdatel'stvo N–L. 2013; 672 p.
8. Abdullina GA, Safna AI, Daminova MA. Klinicheskaja fziologija pochek u nedonoshhennyh: rol' dinamicheskogo nabljudenija [Clinical physiology of the kidneys in premature: the role of follow-up]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Contemporary Clinical Medicine]. 2014; 7 (6): 9–13.
9. Daminova MA, Safna AI, Satrutdinov MA, Hamzina GA. Morfofukcional'nye osobennosti organov mochevoj sistemy u detej, rodivshihsja nedonoshennymi i malovesnymi [Morphological and functional features of the urinary system in children born preterm and LBW]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Contemporary Clinical Medicine]. 2013; 6 (2): 79–86.
10. Sweet DG, Carnielli V, Greisen G, Hallman M et al. European Consensus Guidelines on the Management of Neonatal Respiratory Distress Syndrome in Preterm Infants. Neonatology. 2013; 103: 353–368.
11. Gomella TL. Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs. New York: McGraw-Hill Education-Europe. 2009; 894 p.
12. Prakash Vemgal, Arne Ohlsson. Interventions for non-oliguric hyperkalaemia in preterm neonates. The Cochrane Library; Cochrane Neonatal Group. 2012; DOI: 10.1002/14651858.CD005257.
13. Metodicheskoe pis'mo № 15–0/10/2–11336 Min-zdravsocrazvitija RF ot 16.11.2011 «Intensivnaja terapija i principy vyhazhivanija detej s jekstremal'no nizkoj i ochen' nizkoj massoj tela pri rozhdenii» [Methodical letter # 15–0 / 10 / 2–11336 Health Ministry of the Russian Federation dated 16.11.2011 «Intensive care and the principles of nursing of children with extremely low and very low birth weight»].
14. Safna AI. Osteopenija nedonoshennyh [Osteopenia of prematurity]. Vestnik sovremennoj klinicheskoj mediciny [The Bulletin of Contemporary Clinical Medicine]. 2013; 6 (6): 114–119.
PROBLEMS OF DIAGNOSIS AND TREATMENT OF DIABETIC KETOACIDOSIS IN CHILDREN AND ADOLESCENTS
UDC 616.379-008.64-053.2-06(042.3)
DOI: 10.20969/VSKM.2016.9(2).93-97
SULTANOVA LJUDMILA M., с. Med. Sci., associate professor of the Department of endocrinology of Kazan State Medical Academy, Russia, 420012, Kazan, Mushtari str., 11, tel. +7(843)562-31-61
Abstract. Aim — to provide advanced information on the methods of diagnosis and treatment of diabetic ketoacidosis in children and adolescents. Material and methods. This article was prepared based on the analysis of domestic and international consensus, dealing with management of children with endocrine diseases, on the analysis of the evidence base methods of diagnosis and treatment for generalized data of global and domestic publications and personal experience of leading pediatric endocrinologists Russia (Federal clinical guidelines (protocols) on management of children with endocrine diseases, 2014). Results and discussion. Acute high-risk complications in critical state of diabetes mellitus includes diabetic ketoacidosis and diabetic coma. Diabetic ketoacidosis remains the main cause of hospitalization, disability and death in children and adolescents with type 1 diabetes. Conclusion. Early diagnosis of diabetic ketoacidosis and adequate therapy will help to respond appropriately to achieve relief and prevent adverse outcomes.
Key words: diabetes mellitus, diabetic ketoacidosis.
For reference: Sultanova LM. Problems of diagnosis and treatment diabetic ketoacidosis in children and adolescents. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (2): 93—97.
References
1. Dedov II, Peterkova VA. Federal'nye klinicheskie rekomendacii (protokoly) po vedeniju detej s jendokrinnymi zabolevanijami [Federal clinical guidelines (protocols) on the management of children with endocrine diseases]. Moskva: Praktika [Moscow: Practice]. 2014; 442 p.
2. Sultanova LM, Gajsina LR, Shajdullina MR. Diagnostika i lechenie ketoacidoza pri saharnom diabete u detej [Diagnosis and treatment of ketoacidosis in diabetes mellitus in children]. Prakticheskaja medicina [Practical medicine]. 2008; 27: 43-45.
3. Potemkin VV, Starostina EG. Neotlozhnaja jendokrinologija: rukovodstvo dlja vrachej; Diabeticheskij ketoacidoz [Emergency Endocrinology: a guide for physicians; Diabetic ketoacidosis]. Moskva: Medicinskoe informacionnoe agentstvo [Moscow: Medical Information Agency]. 2008; 11-125, 365-387.
4. Brown TB. Cerebral oedema in childhood diabetic ketoacidosis: Is treatment a factor? Emerg Med J. 2004; 21: 141-144.
5. Wolfsdorf J, Glazer N, Sperling MA. Diabetic ketoacidosis in infants, children and adolescents: A consensus statement from the American Diabetes Association. Diabetes Care. 2006; 29: 1150-1159.
VITAMIN AND MINERAL COMPLEXES IN PEDIATRICS
UDC 616.391-053.2-085.356(042.3)
DOI: 10.20969/VSKM.2016.9(2).97-103
FAIZULLINA REZEDA A., D. Med. Sci., professor, Head of the Department of propedeutic pediatric disease of Kazan State Medical university, Russia, Kazan, Butlerov str., 49, tel. +7(843)236-71-72, e-mail: r868@mail.ru
ZAKIROVA ALFIYA M., C. Med. Sci., associate professor of the Department of propedeutic pediatric disease of Kazan State Medical university, Russia, Kazan, Butlerov str., 49, tel. +7-927-033-93-41, e-mail: azakirova@gmail.com
Abstract. The role of vitamins and minerals in preservation of human health has the extreme importance. Aim — to analyze the impact of vitamin and mineral complexes on a children's organism. Material and methods. The review of publications of domestic and foreign authors was carried out, data of randomized clinical and epidemiological trials are studied. Results and discussion. The role of vitamins and microelements in the child's organism, detailed characteristics of hyper-, hypo- and avitaminosis, prevention of hypovitaminoses which can be a guideline for the practicing doctors who are carrying out maintaining and treatment of such patients are presented. During the increased physical and intellectual activities, infectious diseases and stressful states, intensive growth, and also during change of climatic conditions the child needs to fll shortage of vitamins and minerals by application of vitamin and mineral complexes. Conclusions. According to studied data course application of polyvitaminic preparations and vitamin and mineral complexes can be used within complex medico-preventive training of children before receipt and during adaptation to preschool institutions and school.
Key words: treatment, prevention, children, vitamins, mineral complexes.
For reference: Faizullina RА, Zakirova AМ. Vitamin and mineral complexes in pediatrics. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (2): 97—103.
References
1. Kosenko IM. Mikronutrienty i zdorov'e detej [Micronutrients and health of children]. Voprosy sovremennoj pediatrii [Questions of modern pediatrics]. 2011; 10 (6): 179-185.
2. Vishneva EA, Torshhoeva RM, Barannik VA, Levina JuG, Jefendieva KE, Alekseeva AA. Korrekcija vitaminno-defcitnyh sostojanij u detej s atopiej [Correction of vitamin deficiency at children with atopia]. Pediatricheskaja farmakologija [Pediatric pharmacology]. 2011; 8 (1): 101–104.
3. Josenak Milos, Ciljakova Miriam, Rennerova Zuzana et al. Recurrent Respiratory Infections in Children — Defnition, Diagnostic Approach, Treatment and Prevention. In Tech. 2011; http://cdn.intechweb.org/pdfs/17357.pdf
4. Litvickij PF. Narushenija obmena vitaminov [Violations of an exchange of vitamins]. Voprosy sovremennoj pediatrii [Questions of modern pediatrics]. 2014; 13 (4): 40-47.
5. Namazova-Baranova LS, Torshhoeva RM, Barannik VA, Borovik TJe, Makarova SG, Vishneva EA, Alekseeva AA, Voznesenskaja NI. Obosnovannost' primenenija polivitaminnyh preparatov u detej s atopicheskim dermatitom [Validity of application of polyvitaminic preparations for children with atopic dermatitis]. Pediatricheskaja farmakologija [Pediatric pharmacology]. 2012; 9 (2): 60-66.
6. Racional'noe pitanie: normy fziologicheskih potrebnostej v jenergii i pishhevyh veshhestvah dlja razlichnyh grupp naselenija Rossijskoj Federacii [Balanced diet: norms of physiological needs for energy and feedstuffs for various groups of the population of the Russian Federation]. Metodicheskie rekomendacii [Guidelines] MR 2.3.1.2432-08.
7. Brehm JM, Schuemann B, Fuhlbrigge AL et al. Serum vitamin D levels and severe asthma exacerbations in the Childhood Astma Management Program study. J Allergy Clin Immunol. 2010; 126 (1): 52–58.
8. Vil'ms EA, Turchaninov DV, Bojarskaja LA, Turchaninova MS. Sostojanie mineral'nogo obmena i korrekcija mikrojelementozov u detej doshkol'nogo vozrasta v krupnom promyshlennom centre zapadnoj Sibiri [Condition of a mineral exchange and correction of microelements in children of preschool age in the large industrial center of Western Siberia]. Pediatrija [Pediatrics]. 2010; 89 (1): 81–86.
9. Iozefovich OV. Vitaminno-mineral'nye kompleksy dlja detej [Vitamin and mineral complexes for children]. Pediatricheskaja farmakologija [Pediatric pharmacology]. 2011; 8 (4): 135–138.
10. Stennikova OV, Levchuk LV, Sannikova NE Proflaktika deficitnyh po vitaminam i mineral'nym veshhestvam sostojanij u detej [Prevention vitamins and mineral substances defciency at children]. Voprosy sovremennoj pediatrii [Questions of modern pediatrics]. 2012; 11(1): 56-60.
11. Mihajlov IB. Osnovy farmakoterapii detej i vzroslyh: Rukovodstvo dlja vrachej [Fundamentals of pharmacotherapy of children and adults: The manual for doctors]. SPb: Sova. 2010; 798 p.
12. Van Oeffelen AAM, Bekkers MBM, Smit HA et al. Serum micronutrient concentrations and childhood asthma: The PIAMA birth cohort study. Pediatric Allergy and Immunology. 2011; 22(8): 784-793.
13. Kovrigina ES, Pankov DD, Kljuchnikova IV Primenenie vitaminno-mineral'nogo kompleksa s raznoj kursovoj dlitel'nost'ju u chasto bolejushhih detej v uslovijah dnevnogo stacionara [Application of a vitamin and mineral complex with different course duration at often ill children in the conditions of a daily hospital]. Pediatrija [Pediatrics]. 2012; 91(6): 122-128.
14. Valiev VS, Safna AI, Sirotkin EA. Vlijanie mikrojelementov na processy perekisnogo okislenija lipidov [Effect of
microelements on the processes of lipid peroxidation]. Pediatrija, Zhurnal imeni GN Speranskogo [Pediatrics, Magazine named GN Speransky]. 1996; 6: 99. 15. Zaharova IN, Dmitrieva JuA, Tvorogova TM, Vasil'eva SV, Evseeva EA. Chto nuzhno znat' pediatru o vitamine D: novye dannye o ego roli v organizme (chast' 2) [That the pediatrician needs to know about vitamin D: new data on its role in an organism (part 2)]. Pediatrija [Pediatrics]. 2014; 6: 125-131.
UDC 616-053.1-07(470.41)
DOI: 10.20969/VSKM.2016.9(2).104-109
VAFIN ADELE YU., C. Med. Sci., Minister of Health of the republic of tatarstan, Head of the Department of management in health care of Kazan State Medical university, Russia, 420111, Kazan, ostrovsky str., 11/6, tel. +7(843)231-79-98, e-mail: Adel.Vafin@tatar.ru
IGNASHINA ELENA G., C. Med. Sci., Head of the Department of organization of medical care to children and services of obstetric aid of Ministry of Health of the republic of tatarstan, assistant of professor of the Department of pediatrics and neonatology of Kazan State Medical Academy, Russia, 420111, Kazan, ostrovsky str., 11/6, tel. +7(843)231-79-82, e-mail: elena.ignashina@tatar.ru
Abstract. Aim. To estimate the importance of the main screening programs for congenital and hereditary diseases (CHD) in pregnant women, fetus and newborns. Material and methods. The analysis of screenings results of early CHD diagnostics in the prenatal, perinatal and neonatal periods is carried out. The assessment of the main indicators of work and activity of the medical organizations for CHD diagnostics is given. When carrying out the analysis of indicators data of ROSSTAT (Federal Statistics) of the Russian Federation and Tatarstanstat (Local Statistics) were used. Results and discussion. Effciency of the screening programs directed on earlier detection of congenital and hereditary pathology is noted. Growth of incidence and decrease in infantile mortality on a class of diseases: congenital anomalies (malformations), deformation and chromosomal violations is established. The model of arrangement of tasks in service of obstetric aid and the childhood directed on timely diagnostics and preservation of health of the children's population is created. Congenital defects screening programs promotes its early identifcation, optimum treatment, rehabilitation and quality of life. Conclusions. Antenatal diagnostics methods and introduction of modern neonatal screening technologies are the main reserves of decline in mortality of the population from this pathology.
Key words: congenital malformations, infantile mortality, screening, pregnant women, prenatal diagnostics.
For reference: Vafn AYu, Ignashina EG. Early diagnosis of congenital pathology as signifcant reserve of decrease in incidence and mortality of the population (experience of the Republic of Tatarstan). The Bulletin of Contemporary Clinical Medicine. 2016; 9 (2): 104—109.
References
1. Informacionnyj bjulleten' Vsemirnoj organizacii zdravoohranenija: 2010 [Information Bulletin of the World Health Organization: 2010]. Access: http://apps.who.int/ 5. gb/ebwha/pdf_fles/WHA63/A63_10—ru.pdf
2. Chernenkov JuV, Nechaev VN. Diagnostika, proflaktika i korrekcija vrozhdennyh porokov razvitija [Diagnosis, prevention and correction of congenital malformations]. Saratovskij nauchno—medicinskij zhurnal [Saratov Journal of Medical Science]. 2009; 5 (3): 379–383.
3. Kinsht DA, Soboleva MK, Ajzikovich IV. Rasprostranennost' vrozhdennyh porokov razvitija u novorozhdennyh posle primenenija vspomogatel'nyh reproduktivnyh tehnologij [The prevalence of congenital malformations in infants after 6. application of assisted reproductive technologies]. Vestnik ural'skoj medicinskoj akademicheskoj nauki [Bulletin of Ural Medical Academic Science]. 2014; 4: 44—48.
4. Adamjan LV, Barabashkina AV, Bigan NA, Galjavich AS. Diagnostika i lechenie serdechno—sosudistyh
zabolevanij pri beremennosti [Diagnosis and treatment of cardiovascular diseases during pregnancy]. Rossijskij kardiologicheskij zhurnal [Russian Journal of Cardiology]. 2013; 4: 1—40.
Abuseva AV, Teregulova LE, Vafna ZI et al. Prenatal'naja diagnostika hromosomnyh anomalij u plodov, voshedshih v gruppu srednego i nizkogo riska po rezul'tatam kombinirovannogo prenatal'nogo skrininga I trimestra po modulju FMF [Prenatal diagnosis of chromosomal abnormalities in fetuses included in the group of medium and low risk based on the results of the combined trimester prenatal screening and modulo FMF]. Prakticheskaja medicina [Practical Medicine]. 2014; 3: 112—117.
Mahacheva HG, Ashabova LM, Dajhes NA. Sravnitel'naja harakteristika audiologicheskih skriningovyh issledovanij u novorozhdennyh [Comparative characteristics of audiological screening in newborns]. Prakticheskaja medicina [Practical Medicine]. 2014; 9 (85): 131— 134.
FEATURES OF PHARMACOLOGICAL EFFECTS OF ANTI-HYPERTENSIVE DRUGS IN ELDERLY PATIENTS
UDC 616.12-008.331.1-053.9-085.225.2
DOI: 10.20969/VSKM.2016.9(2).110-116
ABDRAKHMANOVA ALSU I., C. Med. Sci., associate professor of the Department of cardiology, roentgen-endovascular and cardiovascular surgery of Kazan State Medical Academy, Russia, 420012, Kazan, Mushtari str., 11, associate professor of the Department of clinical medicine fundamental basis of the institute of biology and fundamental medicine of Kazan federal university, Russia, 420012, Kazan, Karl Marx str., 74, tel. 8-917-922-66-29, e-mail: alsuchaa@mail.ru AMIROV NAIL B., D. Med. Sci, professor of the Department of general medical practice of Kazan State Medical university, Russia, 420012, Kazan, Butlerov str., 49, e-mail: namirov@mail.ru
TSIBULKIN NIKOLAY A., C. Med. Sci., associate professor of the Department of cardiology, roentgen-endovascular and cardiovascular surgery of Kazan State Medical Academy, Russia, 420012, Kazan, Mushtari str., 11
Abstract. Aim. To analyze the last publications devoted to features of pharmacological effects of anti-hypertensive drugs in elderly patients. Material and methods. The review of the publications in scientifc medical literature devoted to studying the features of pharmacokinetics and a pharmacodynamics of anti-hypertensive drugs at the patients of advanced age with arterial hypertension complicating planning and carrying out hypotensive therapy at this group of persons was performed. Results and discussion. Hypertension prevalence increases and the further increase in number of the people having this disease is predicted. The greatest number of the deadly outcomes related with irrational pharmacotherapy of a hypertension are among patients in age group of 80—90 years. Besides, patients older 60 years have the 60% frequency of drug intake mistakes and this considerably increases if patient take more than three drugs. The risk of side effects in patients older 60 years is 2—3 times higher. Conclusion. It is necessary to allocate those signs which infuence quality of life in structure of symptoms and demand therapeutic infuence. Physiological processes in senile organism explain divergence and diffculties of drug effect. Given the high risk of side effects of therapy, the treatment of elderly patients should be approached with extreme caution.
Key words: arterial hypertension, antihypertensive therapy, pharmacological effects, old age.
For reference: Abdrahmanova AI, Amirov NB, Tsibulkin NA. Features of pharmacological effect of anti-hypertensive drugs in older patients. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (2): 110—116.
References
1. Geraskina LA, Fonjakin AV, Suslina ZA. Antigipertenzivnaja terapija posle insul'ta: kak opredelit' celevoj uroven' arterial'nogo davlenija [Antihypertensive therapy after stroke: how to defne the target level of blood pressure]. 2008. URL: http://angiology.com.ua/article/221.html
2. Denisova T P, Malinova LI. Klinicheskaja gerontologija: Izbrannye lekcii [Clinical Gerontology: Selected lectures]. M: Medicinskoe informacionnoe agentstvo [Medical News Agency]. 2008; 256 p.
3. Bagrij AJe. Arterial'naja gipertenzija u lic pozhilogo vozrasta: vozmozhnosti primenenija indapamida [Arterial hypertension in the elderly: the possibility of using indapamide]. Arterial'naja gipertenzija [Arterial hypertension]. 2013; 2 (28): 39–42.
4. Belousov Ju B, Gurevich KG. Klinicheskaja farmakokinetika: praktika dozirovanija lekarstv [Clinical pharmacokinetics: the practice of dispensing of drugs]. M: Litterra. 2005; 288 p.
5. Belousov JuB, Leonova MV. Osobennosti primenenija lekarstva v geriatricheskoj praktike [Features of the application of the drug in geriatric practice]. Farmateka [Farmateka]. 2008; 8: 13–19.
6. Vertkin AL, Skotnikov AS, Li ED et al. Starenie: Professional'nyj vrachebnyj podhod [Aging: Professional medical approach]. M: JEKSMO. 2013; 320 p.
7. Gazizov RM. Osnovy lekarstvennoj terapii v pozhilom i starcheskom vozraste: lekcii dlja vrachej obshhej praktiki [Fundamentals of drug therapy in elderly and senile age: lectures for general practitioners]. Prakticheskaja medicina [Practical medicine]. 2010; 2 (10): 5.
8. Diagnostika i lechenie arterial'noj gipertonii: Klinicheskie rekomendacii MZ RF [Diagnosis and treatment of hypertension. Clinical guidelines]. M. 2013; URL: http:// cardioweb.ru/klinicheskie–rekomendatsii
9. Ermolaeva AS, Dralova OV, Maksimov ML. Bezopasnaja gipotenzivnaja terapija: snizhenie AD ili kontrol'? [Secure antihypertensive therapy: reduction of blood pressure or control?]. Russkij medicinskij zhurnal [Russian Medical Journal]. 2014; 4: 293–297.
10. Karpov JuA, Starostin IV. Novye rekomendacii ESH/ESC 2013 goda po lecheniju arterial'noj gipertonii: osnovnye izmenenija [The new guidelines ESH / ESC 2013 for the treatment of hypertension: the main changes]. Russkij medicinskij zhurnal [Russian Medical Journal]. 2013; 27: 1290–1294.
11. Kukesa VG, Sycheva DA. Klinicheskaja farmakokinetika: teoreticheskie, prikladnye i analiticheskie aspekty: rukovodstvo [Clinical pharmacokinetics: theoretical, applied and analytical aspects: leadership]. M: GJeOTAR– Media. 2015; 1024 р.
12. Libov IA, Gajnullin AR, Ermisheva JuA. Osobennosti lechenija arterial'noj gipertonii u licgpozhilogo i starcheskogo vozrasta [Ermisheva Features of treatment of hypertension in elderlies and senile]. Medicinskij sovet [Medical advice]. 2010; 1: 28–33.
13. Morozova TE, Vartanova OA, Lukina MB. Farmakoterapija arterial'noj gipertenzii u pozhilyh [Pharmacotherapy of hypertension in the elderly]. Lechashhij vrach [Therapist]. 2014; 7: 32–37.
14. Morozova TE. Farmakoterapija hronicheskih serdechno– sosudistyh zabolevanij [Pharmacotherapy of chronic cardiovascular diseases:] M. 2011; 392 р.
15. Fonjakin AV. Arterial'naja gipertenzija i insul't: strategija i taktika antigipertenzivnoj terapii [Hypertension and stroke: strategy and tactics of anti–hypertensive therapy]. Zdorov'e Ukrainy [Health of Ukraine]. 2007; 1 (6): 9–11.
16. Ljusov VA., Harchenko VI, Kakorin VA et al. Opredelenie celevyh urovnej arterial'nogo davlenija pri gipotenzivnoj terapii u bol'nyh s tjazheloj rezistentnoj k terapii arterial'noj gipertoniej [Identify target levels of blood pressure during antihypertensive therapy in patients with severe treatment–resistant hypertension]. Rossijskij kardiologicheskij zhurna [Russian Cardiology Journal]. 2008; 2: 67–82.
17. Jarygin VN, Melent'ev AS. Rukovodstvo po gerontologii i geriatrii: Klinicheskaja geriatrija [Guidelines for Gerontology and Geriatrics: Clinical Geriatrics]. M: Geotar– media. 2010; 3: 896 р.
18. Parfjonov VA. Povtornyj ishemicheskij insul't i ego proflaktika u bol'nyh s arterial'noj gipertenziej [Repeated ischemic stroke and its prevention in patients with hypertension]. Zhurnal nevrologii i psihiatrii imeni Korsakova SS: Insul't. [Journal of Neurology and Psychiatry named SS Korsakov: Stroke]. 2005; 14: 3–7.
19. Amirov NB, Galeeva ZM, Gornaeva LI et al. Voprosy kliniki, diagnostiki, differencial'noj diagnostiki, lechenija i profilaktiki arterial'nyh gipertenzij [Questions clinic, diagnosis, differential diagnosis, treatment and prevention of arterial hypertension]. Kazan': Medicina [Kazan: Medicine]. 2010; 128 р.
PRACTICAL ASPECTS OF THE MEDICAL ORGANIZATION PERSONNEL MOTIVATION MANAGEMENT
UDC 614.25:331.101.3
DOI: 10.20969/VSKM.2016.9(2).117-119
BREUSOV ALEXEY V., D. Med. Sci., professor of the Department of public health, health service and hygiene of the Medical faculty of the Russian Peoples' friendship university, Russia, 117198, Moscow, Miclukho-Maclay str., 6, tel. 8(495)434-52-77, e-mail: ab69@yandex.ru
CHIRKOV VITALIY A., C. Med. Sci., deputy Head physician of the city clinical Psychiatric Hospital № 15 of Moscow Health Department, Russia, 115522, Moscow, Moscworechje, str., 7, tel. 8(916)833-36-30, e-mail: a123b@bk.ru
ZINOVIEV PAVEL V., graduate student of the Department of health management of Kazan State Medical university, Russia, 420012, Kazan, Butlerov str., 49, tel. 8(905)315-08-00, e-mail: pavel.zinovyev@gmail.com
Abstract. Aim: 1) to determine the most effective personnel motivation methods used by the medical organizations leaders; 2) to develop practical recommendations reducing the impact of the personnel demotivation factors. Material and methods. 409 chiefs from 30 medical organizations of Moscow (18 — outpatient medical centers, 12 — City Clinical Hospital) took part in a conducted sociological survey. Specifcally designed questionnaire was used to poll the respondents. Results were processed in accordance with existing procedures for the organization of sociological surveys. Results and discussion. Overall, both tangible and intangible methods of employees’ incentives are acceptable. The most effective tangible methods are: 1) differentiated payments to staff as a result of work (83,6% of respondents); 2) unifed remuneration system for all medical organizations of the region (52,4%). Intangible: 1) conditions for an interesting, self and creative work (24,2%); 2) career growth (21,6%); 3) access for the employees to the information needed to make right decisions (16,3%) etc. Conclusions. Applying of the aforementioned tangible and intangible methods of employees’ incentives helps to avoid development of demotivation process and labor dissatisfaction.
Key words: medical organization, staff, personnel, motivation, demotivation, management.
For reference: Breusov AV, Chirkov VA, Zinoviev PV. Practical aspects of the medical organization personnel motivation management. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (2): 117—119.
References
1. Alehina OE. Stimulirovanie razvitija rabotnikov organizacii [Development incentives of the organization employees]. Upravlenie personalom [Personnel management]. 2010; 1: 50-52.
2. Osipova JeV. Faktory motivacii personala [Personnel motivation factors]. Personal-Miks [Personnel-mix]. 2002; 6: 13-14.
3. Shulaev AV, Blohina MV, Urazova ON et al. Menedzhment v zdravoohranenii [Health management]. Kazan': Medicina [Kazan: Medicine]. 2011; 125 p.
4. Andreeva TN. Pochemu uhodjat luchshie: problema demotivacii personala [Why the best quit: personnel demotivation problem]. Upravlenie personalom [Personnel management]. 2011; 4: 21.
5. Bogdanov JuN, Zorin JuV, Shmonin DA et al. Motivacija personala [Personnel motivation]. Metody menedzhmenta kachestva [Methods of quality management]. 2008; 11: 14-19.
UDC 616-053.9-084
DOI: 10.20969/VSKM.2016.9(2).120-124
ZHABOYEVA SVETLANA L., C. Med. Sci., senior lecturer of the Department of preventive medicine and person ecology of Kazan State Medical university, Russia, 420012, Kazan, Butlerov str., 49, director of clinic of Youth and Beauty Sl, Russia, 420126, Kazan, Adoratsky str., 3, head research worker of the Department of organization gerontological help and scientific researches in gerontology and geriatrics of research Medical center «Gerontologiya», Russia, 125319, Moscow, 1-st Aeroportovskaya str., 6, room Vi, 1—4, e-mail: clinic-sl@mail.ru
RADCHENKO OLGA R., D. Med. Sci., associate professor of the Department of preventive medicine and person ecology of Kazan State Medical university, Russia, 420012, Kazan, Butlerov str., 49, e-mail: olga.radchenko@Kazangmu.ru
Abstract. Aim. The assessment of medical and economic effciency of the offered personifed prevention associated-age diseases model was performed. Material and methods. Patients 3652 persons aged from 35 till 74 years took part in research. We used epidemiological, medico-sociological and statistical methods, method of expert evaluations and questioning of patients with SF-36 questionnaire. The assessment of economic effciency was carried out on the basis of calculation of an indicator of «the life lost years» as a result of premature occurrence of death and disability of DALY (disability adjusted life years) and an indicator of QALY (quality adjusted life years) for 1 year of the prolonged life. Results and discussion. Reliable improvement of indicators of physical and psychological components of health after passing the basic prevention programs is established. When passing by patients of preventive programs there is a prevention of losses of health what DALY indicator increment testifes to. At the same time, the most effective is application of the personifed prevention for patients of middle age. With introduction of alleged personifed prevention approach age-associated diseases and the coeffcient of usefulness of 1 year of the prolonged life with improvement of quality of life and reduction of number of years of «defective life» or disability at 1 patient will make 30 430,0 rubles (economy). Conclusion. The assessment of medical and economic effciency has shown that introduction of the offered model is valuable.
Key words: the personifed prevention, ageassociated diseases, medical and economic effciency.
For reference: Zhaboyeva SL, Radchenko OR. Аssessment of medical and economic effciency from the personifed prevention model introduction the diseases connected with age. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (2): 120—124.
References
1. Neinfekcionnye zabolevanija [Noninfectious diseases]. Informacionnyj bjulleten' VOZ № 355 [Newsletter of WHO № 355]. 2015; Access: http://www.who.int/mediacentre/ factsheets/fs355/ru/
2. Gulevich AP, Krivelevich EB, Han IS. Programma vybora optimal'noj strategii i kriterii ocenki jeffektivnosti proflaktiki neinfekcionnyh zabolevanij [Program of the choice of optimum strategy and criteria for evaluation of effciency of prevention of noninfectious diseases]. Tihookeanskij medicinskij zhurnal [Pacifc medical magazine]. 2011; 3: 64–67.
3. Bojcov SA. Profilaktika neinfekcionnyh zabolevanij v strane: ot «chto delat'» k «kak delat'» [Prevention of noninfectious diseases in the country: from «what to do» to «how to do»]. Proflakticheskaja medicina [Preventive medicine]. 2012; 2: 3–10.
4. World population ageing 1950–2050. Executive Summary. New York: United Nations population Division. 2001; 46 p.
5. Rimashevskoj NM ed. Zdorov'e i zdravoohranenie v gendernom izmerenii [Health and health care in gender measurement]. Moskva: Social'nyj proekt [Moscow: Social Project]. 2007; 240 р.
6. Mjakotnyh VS, Sidenkova AP, Borovkova TA, Berezina DA. Medicinskie, psihologicheskie, social'nye i gendernye aspekty starenija v sovremennoj Rossii [Medical, psychological, social and gender aspects of aging in modern Russia]. Uspehi gerontologii [Achievements of gerontology]. 2014; 27 (2): 302–309.
7. Moroz IN. Fizicheskij i psihologicheskij komponenty zdorov'ja pozhilyh i ih udovletvorennost' oKazaniem mediko-social'noj pomoshhi [Physical and psychological components of health elderly and their satisfaction with rendering the medico-social help]. Uspehi gerontologii. [Achievements of gerontology]. 2014; 27 (4): 678–683.
8. Groot V, Beckerman H, Lankhorst G, et al. How to measure comorbidity: a critical review of available methods. J Clin Epidmiol. 2003; 56: 221–229.
9. Karlamangla A, Tinetti M, Guralnik J, et al. Comorbidity in older adults: nosology of impairment, diseases, and conditions. J Gerontol A Biol Sci Med Sci. 2007; 62 (3): 296–300.
10. Weel C, Schellevis FG. Comorbidity and guidelines: conficting interests. Lancet. 2006; 367: 550–551.
11. Zhaboeva SL, Bermusova AL. Podkhody k individualnoi profilaktike vozrast–zavisimoi patologii [Approaches to individual prevention age — dependent pathology]. Gerontologicheskii zhurnal imeni VF Kuprevicha [Gerontological magazine of VF Kuprevich]. 2011; 6: 72–75.
12. Ivanov SV, Khammad EV, Zhaboeva SL, Mursalov SU. Podkhody k sozdaniiu i realizatcii personiftcirovannykh programm proflaktiki vozrastassotciirovannykh zabolevanii [Approaches to creation and implementation of the personifed programs of prevention age — the associated diseases]. Klinicheskii opyt Dvadtcatki [Clinical experience of the Twenty]. 2015; 4 (28): 119–125.
UDC [616.98:579.835.12]-054(470.631)
DOI: 10.20969/VSKM.2016.9(2).124-128
KOTELEVETS SERGEY M., D. Med. Sci., professor, acting of Head of the Department of internal medicine propaedeutics of Medical institute of north-caucasian State Humanitarian and technological Academy, Russia, 369000, Karachay-cherkess republic, Cherkessk, Stavropol str., 36
GALEEVA ZARINA M., C. Med. Sci., associate professor of the Department of therapy of Kazan State Medical Academy, Russia, 420012, Kazan, Mushtary str., 11
KARAKOTOVA ZUKHRA B., postgraduate of the Department of internal medicine propaedeutics of Medical institute of north-caucasian State Humanitarian and technological Academy, Russia, 369000, Karachay-cherkess republic, Cherkessk, Stavropol str., 36
TEBUEVA MARGARITA A., postgraduate of the Department of internal medicine propaedeutics of Medical institute of north-caucasian State Humanitarian and technological Academy, Russia, 369000, Karachay-cherkess republic, Cherkessk, Stavropol str., 36
Abstract. Aim. The purpose of the study was to identify differences in the prevalence of Helicobacter pylori infection among different ethnic groups. Material and methods. To estimate the prevalence of Helicobacter pylori infection among the different ethnic groups in the Karachay-Cherkessia Republic for 2012—2013 years we performed non-invasive serological detection of Helicobacter pylori (HP) infection in health care facilities in the city of Cherkessk and areas of the region with the help of a test panel for the enzyme immunoassay «GastroPanel» with the assessment of anti-HP IgG titer. The study included 2865 patients aged 18 to 89 years. All subjects are divided into six groups based on ethnicity. Results and discussion. Karachay, Russian, Cherkess, Abaza, Nogai — were the main nationalities living in Karachaevo-Circassian Republic and other nationalities living in the Republic of Karachay-Cherkessia were signifcantly fewer (ossetians, greeks, ukrainians, armenians, georgians, chechens and others). Conclusions. As a result of this study, demonstrated that the prevalence of Helicobacter pylori infection among Abaza, Circassians, Karachai and Russian, did not differ between men and women, but among the Nogai and other nationalities (ossetians, greeks, ukrainians, armenians, georgians, chechens) fairly male-dominated result was observed.
Key words: prevalence, infection of Helicobacter pylori, gender differences.
For reference: Kotelevets SM, Galeeva ZM, Karakotova ZB, Tebueva MA. Genderal and populational differences of helicobacter pylori infection prevalence in different ethnic groups. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (2): 124—128.
References
1. Maev IV, Andreev DN, Kucherjavyj JuA. Patogeneticheskie
i klinicheskie paralleli infekcii Helicobacter pylori i MALT- 6. limfomy zheludka [Pathogenic and clinical parallels of Helicobacter pylori infection and MALT-lymphoma of the stomach]. Gastrojenterologija. Prilozhenie k zhurnalu Consilium Medicum [Gastroenterology. Supplement to the Consilium Medicum]. 2014; 2: 5–9.
2. Kotelevec SM. Novaja paradigma v ponimanii prichiny zabolevanij [The new paradigm in understanding the causes of diseases]. Dnevnik Kazanskoj medicinskoj 7. shkoly [Diary of the Kazan medical school]. 2013; 2: 96–101.
3. Kotelevec SM. Sovremennye aspekty dispanserizacii opredeljonnyh grupp naselenija [Modern aspects of clinical examination of certain population groups]. Dnevnik Kazanskoj medicinskoj shkoly [Diary of the Kazan medical school]. 2013; 3: 31–34.
4. Kotelevec SM. Kak provodit' skrining i profilaktiku predrakovyh sostojanij zheludka? Po itogam programmy 8. po skriningu i proflaktike predrakovyh sostojanij zheludka, realizujushhejsja v Karachaevo-Cherkesskoj Respublike (prakticheskie rekomendacii) [How to screen and prevent
the precancerous lesions of the stomach? As a result of screening programs and prevention of precancerous 9. lesions of the stomach, which is realized in the Karachay– Cherkess Republic (practical recommendations)]. Dnevnik Kazanskoj medicinskoj shkoly [Diary of the Kazan medical school]. 2014; 1 (4): 11–15.
5. Kotelevec SM. Vozrastnaja dinamika inficirovannosti Helicobacter pylori u starshih vozrastnyh grupp [Age
dynamics of Helicobacter pylori infection in older age groups.]. Dnevnik Kazanskoj medicinskoj shkoly [Diary of the Kazan medical school]. 2015; 2 (8): 11–12.
6. Lehanova SN. Morfologicheskaja harakteristika HP-associirovannyh gastritov u detej i podrostkov Jakutii [Morphological characterization of HP-associated gastritis in children and adolescents of Yakutia]. Vestnik Novosibirskogo gosudarstvennogo universiteta. Serija: Biologija, klinicheskaja medicina [Bulletin of the Novosibirsk State University. Series: biology, clinical medicine]. 2009; 1: 72–76.
7. Dzhumabaev MN. Vzaimosvjaz' kurenija, upotreblenija alkogolja, patologii zubov i rasprostranjonnosti Helicobacter pylori sredi jetnicheskih grupp v Kyrgyzstane [The relationship of smoking, alcohol use, dental disease, and the prevalence of Helicobacter pylori among ethnic groups in Kyrgyzstan]. Jeksperimental'naja i klinicheskaja gastrojenterologija [Experimental and clinical gastroenterology]. 2015; 6 (118): 16–20.
8. Ivanov AM. Polimorfizm receptorov vrozhdjonnogo immuniteta [Receptor polymorphisms of innate immunity]. Vestnik Rossijskoj voenno-medicinskoj akademii [Bulletin of the Russian Military Medical Academy]. 2009; 1 (25): 172–184.
9. Matjushechkin EV. Citokinovyj status i kliniko– morfologicheskie osobennosti gastroduodenal'noj zony u bol'nyh poluchajushhih zamestitel'nuju pochechnuju terapiju [Cytokine status and clinical and morphological features of gastroduodenal zone in patients receiving renal replacement therapy]. Nefrologija [Nephrology]. 2007; 11 (4): 64–68.
UDC 616.61-002.151-052:374
DOI: 10.20969/VSKM.2016.9(2).128-132
KHASANOVA GUZEL M., D. Med. Sci., professor of the Department of infectious diseases of Bashkir State Medical university, Russia, Ufa, tel. 8-917-470-40-36, e-mail: nail_ufa1964@mail.ru
VALISHIN DAMIR A., D. Med. Sci., Professor, the main infectious diseases of the Ministry of Health of the republic of Bashkortostan, Head of the Department of infectious diseases of Bashkir State Medical university, Russia, Ufa, tel. 8-917-754-86-45, e-mail: damirval@yandex.ru
KHASANOVA ALYA N., student of Bashkir State Medical university, Russia, Ufa, tel. 8-917-470-40-36, e-mail: nail_ufa1964@mail.ru
Abstract. Aim — to study patient school effectiveness for people suffered from hemorrhagic fever with renal syndrome (HFRS) in post hospital rehabilitation. Material and methods. Educational program was presented to 57 men suffered from moderate and severe form of HFRS. A control group consisted of people who did not undergo training. The program effectiveness was estimated by patient’s clinical status, their compliance, eating behavior, psychological analysis and quality of life changes as well as level of nutrition education, healthy life style and decrease of chronic illnesses risk factors. The assessment of people’s nutrition was performed by food consumption analysis. The questionnaires of the performed prescriptions were used to study cure preferences (compliance). The MFI-20 questionnaire was used to estimate asthenia. The Health Status Survey (SF-36) adapted questionnaire was used to study the quality of life. Quetelet Index was used to defne overweigh: in case of 25 kg/m2 exceed patients considered to be overweighed. Results and discussion. Due to the given program the level of medication and prophylactic examination observation has been improved, disease control behavior has been formed, hypertensive and chronic kidney disease risk factors have been decreased. Post hospital rehabilitation results have been improved as well as preventing urinary tract infections has been statistically proved. Conclusion. The given educational program for patients suffered from HFRS has increased information level of HFRS and chronic disease risk factors consequences.
Key words: patient school, hemorrhagic fever with renal syndrome.
For reference: Khasanova GM, Valishin DA, Khasanova AN. Patient school effectiveness for people suffered from hemorrhagic fever with renal syndrome in post hospital rehabilitation. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (2): 128—132.
References
1. Hasanova GM. Osobennosti zabolevaemosti, techenija, oslozhnenij i ishodov gemorragicheskoj lihoradki s pochechnym sindromom v krupnom promyshlennom gorode [Features incidence, trends, complications and outcomes of hemorrhagic fever with renal syndrome in a large industrial city]. Vestnik Bashkirskogo universiteta [Bulletin of the Bashkir University]. 2007; 4: 45-7.
2. Hasanova GM, Valishin DA, Hasanova AN. Kliniko-jepidemiologicheskie projavlenija gemorragicheskoj lihoradki s pochechnym sindromom v period pod'ema zabolevaemosti v Respublike Bashkortostan [Clinical and epidemiologic manifestations of hemorrhagic fever with renal syndrome during the rise of morbidity in the Republic of Bashkortostan]. Mezhdunarodnyj akademicheskij vestnik. [International Academic Gazette]. 2015; 1: 148-150.
3. Khasanova GM. Aktual’nye aspekty immunopatogeneza, vitaminno-mikroelementnogo balansa i lecheni’ya gemorragicheskoj lihoradki c pochechnym sindromom [Immunopathogenesis and microelement balance urgent issues in hemorrhagic fever with renal syndrome treatment]; abstract Doctoral dissertation, Moscow. 2012; 47 p.
4. Martinchik AN, Baturin AK, Baeva VS, Feoktistova AI, Pjatnickaja IN, Azizbekjan GA, Peskova EV, Bormacheva EA. Razrabotka metoda issledovanija fakticheskogo pitanija po analizu chastoty potreblenija pishhevyh produktov: sozdanie voprosnika i obshhaja ocenka dostovernosti metoda. [Development of a method of research of the actual power to analyze the frequency of food consumption: the creation of a questionnaire and an overall assessment of the reliability of the method]. Voprosy Pitaniia [Nutrition]. 1998; 3: 8-13.
INFLUENCE OF RAPID ACCELERATED LABOR ON PERINATAL OUTCOMES FOR MOTHER AND CHILD
UDC 618.5
DOI: 10.20969/VSKM.2016.9(2).133-137
ZHELEZOVA MARIA E., с. Med. Sci., associate professor of the Department of obstetrics and gynecology № 1 of Kazan State Medical Academy, Russia, 420012, Kazan, Mushtari str., 11, tel. 8-919-627-13-66, e-mail:gelezovam@gmail.com
YAGOVKINA NATALIA E., obstetrician-gynecologist of the Department of delivery of Medical station of Kazan federal university, Russia, 420008, Kazan, Kremlevskaya str., 18, tel. 8-987-290-48-25, e-mail: natashadoc@yandex.ru
Abstract. Aim. To analyze data on the gestation course and labor’s outcomes in uterine activity pathology. Rapid labor has its characteristics and negative impact on mother and baby. The current labor leads to shortening of labor time and increase of perinatal complications and in some cases to the long-term effects. Accelerated labor is dangerous to health of mother and fetus because of serious complications related to obstetric injuries and diffculty of correction. Material and methods. Taking into account the literature data it is necessary to consider that rapid and accelerated labor are pathological states in connection with unfavorable aftereffects for mother and the child, demanding application of appropriate methods of regulation and treatment. Results and discussion. The literary data shows that there is the necessity of constant observation during the delivery, especially complicated one. Conclusion. Preventive events and detection of pregnant groups of high risk are necessary taking into account the considerable frequency of unfavorable outcomes of labor for mother and fetus conducting at abnormalities of labor. Key words: accelerated and rapid labor, perinatal outcomes, mother’s complications.
For reference: Zhelezova ME, Yagovkina NE. Infuence of rapid accelerated labor on perinatal outcomes for mother and child. The Bulletin of Contemporary Clinical Medicine. 2016; 9 (2): 133—137.
References
1. Abramchenko VV. Rodovaya deyatel'nost' i ee regulyaciya [Uterine activity and its regulation]. SPb: EHLBI-SPb. 2006; 387 p.
2. Baev OR, Belousova VS. Anomalii rodovoj deyatel'nosti u pervorodyashchih zhenshchin starshe 30 let [Anomalies of labor in primiparous women older than 30 years]. Voprosy ginekologii, akusherstva i perinatologii [Questions of gynecology, obstetrics and Perinatology]. 2005; 1: 5–10.
3. Zhelezova ME, Mal'ceva LI, Zefrova TP, Cyplakov DE. Osobennosti techeniya i iskhody bystryh i stremitel'nyh rodov u zhenshchin [Clinical course and outcomes of rapid and accelerated labor in women]. Prakticheskaya medicina [Practical medicine]. 2013; 7: 67–71.
4. Zefirova TP, Zhelezova ME, Yagovkina NE. Faktory riska i usloviya razvitiya bystryh rodov pri urogenital'noj infekcii u zhenshchin [Risk factors and conditions of development of fast labor with urogenital infection in women]. Prakticheskaya medicina [Practical medicine]. 2009; 2: 85–88.
5. Sidel'nikova VM, Antonov AG. Prezhdevremennye rody. Nedonoshennyj rebenok [Premature birth. A premature baby]. M: Geotar-Medicina. 2006; 192–206.
6. Hahn S, Gupta AK, Troeger C et al. Disturbances in placental immunology: ready for therapeutic intervention. Springer SeminImmunopathol.2006; 27: 477–493.
7. Savickij AG, Gul'tyaeva AO, Kuz'mina DN et al. «Sheechnyj faktor» v patogeneze gipertonicheskih disfunkcij matki [«Cervical factor» in the pathogenesis of hypertonic dysfunction of the uterus]. Detskaya medicina Severo-Zapada [Children's medicine of the North-West]. 201; 2: 35-42.
8. Zhelezova ME, Mal'ceva LI, Zefrova TP et al. Novyj vzglyad na bystrye rody [New approach to rapid labour]. Prakticheskaya medicina [Practical medicine]. 2015; 1: 7–10.
9. Badretdinova FF, Gancev SH, Trubin VB. Primenenie kompleksnoj sistemy lechebno-reabilitacionnyh meropriyatij u zhenshchin s akusherskimi travmami shejki matki pri pervyh rodah [An integrated system of treatment and rehabilitation for women with obstetric injuries of the cervix at frst birth]. Ural'skij medicinskij zhurnal [Ural medical journal]. 2013; 3: 101–105.
10. Atavova NM, Hashaeva TH, Omarov NS. Ocenka perinatal'nyh iskhodov u pervoberemennyh pozdnego reproduktivnogo vozrasta s anomaliyami rodovoj deyatel'nosti [Assessment of perinatal outcomes in frst pregnancy and late reproductive age with anomalies of patrimonial activity]. Izvestiya DGPU [Proceedings of DSPU]. 2013; 4: 1–5.
11. Zefrova TP, Zhelezova ME, Yagovkina NE. Bystrye rody: tochka zreniya klinicista [Rapid labor: clinician’s viewpoint]. Prakticheskaya medicina [Practical medicine]. 2011; 6: 57–59.
12. Sidorova IS. Fiziologiya i patologiya rodovoj deyatel'nosti [Physiology and pathology of patrimonial activity]. M: Med. inform. agentstvo [Medical information Agency]. 2006; 240 p.
13. Semenkov OG, Iova AS, Sholomov IA. Osnovnye prichiny i prognosticheskie kriterii neblagopriyatnyh iskhodov u novorozhdennyh, perenesshih vnutrizheludochkovye krovoizliyaniya [Main causes and prognostic criteria of adverse outcomes in neonates who underwent intraventricular hemorrhage]. Saratovskij nauchno-medicinskij zhurnal [Saratov scientifc medical journal]. 2010; 6 (3): 658–663. 14. Mihalev EV, Krivonogova TS, Tropova TE et al. Perinatal'nye porazheniya central'noj nervnoj sistemy v strukture zabolevaemosti novorozhdennyh detej g. Tomska [Perinatal lesions of the Central nervous system in the structure of morbidity of newborn children in Tomsk]. Mat' i ditya v Kuzbasse [Mother and child in Kuzbass]. 2011; 4: 40–42.
15. Evtushenko ID, Radiochenko AA, Krasnonosel'skih TP. Techenie beremennosti i rodov zhenshchin, u detej kotoryh vposledstvii byli vyyavleny psihicheskie zabolevaniya [Pregnancy and childbirth women, the children which were subsequently identifed mental illness]. Rossijskij vestnik akushera–ginekologa [Russian Bulletin of obstetrician– gynecologist]. 2003; 1: 45–48.
16. Butterwegge M, Seelbach-Gobel В, Kuhnert М. Fetal pulse oximetry during risk deliveries in German clinics a representative national survey in 81 obstetric departments. Z. Geburtshilfe. Neonatol. 2002; 206 (3): 83–87.
