Vol. 2 Issue 1 (2009)

Обложка журнала

PDF downloadDownload the whole Issue

Editorial P.5

LEADING ARTICLE

Medical ethics in activity of the medical personnel of medical unit of internal affairs employees. M.V.Potapova, R.S.Mingazov P.6

ORIGINAL ARTICLES

Endothelial dysfunction in patients with chronic heart failure. N.A.Kosheleva, A.P.Rebrov P.9

Clinical and immunological evaluation of the recombinant human interleukine-2 (roncoleukin) efficiency in the treatment of mycoplasmal and chlamidia pneumonias. G.G.Mousalimova, V.N.Saperov, D.S.Markov, L.A.Voropayeva, A.R.Rakhimzyanov, Yu.M.Nagayeva P.14

Estimation of efficiency of recombinant human interleukine-2 (roncoleukin) in complex treatment of patients with steroid-dependent bronchial asthma. T.A.Nikonorova, O.V.Petrova, G.G.Mousalimova, V.N.Saperov, D.S.Markov, L.A.Voropayeva, A.R.Rakhimzyanov, Yu.M.Nagayeva P.20

REVIEWS

Results of dynamic observation after patients with chronic obstructive pulmonary diseases during 2-5 years. Literature review. I.Yu.Vizel, E.I.Shmelev, A.A.Vizel P.27

LECTURES

Non-specific ulcerative colitis: up-to-date approaches to diagnostics and treatment. S.R.Abdoulkhakov,R.A.Abdoulkhakov P.32

Diagnosis and treatment of liver cirrhosis complications. Management of patients with edematicascitis syndrome. I.A.Gimaletdinova P.41

BRIEF ARTICLES

Analysis of results of screening examination of somatic patients for syphilis (on data of polyclinic of Ministry of Internal Affairs of RT). L.K.Bounakova,E.F.Merikova P.47

FOR GENERAL PRACTITIONER

Prophylaxis, diagnostics and treatment of arterial hypertensia. Basic principles, tables, charts and commentaries to Russian recommendations of 2008 (to help the general physician). N.B.Amirov P.49

CLINICAL CASE

Case of successful thrombolysis in the patient with acute myocardial infarction of the left ventricle lower wall in settings of a non-specialized hospital. L.H.Safargaliyeva P.66

____

LEADING ARTICLE

PDF downloadMedical ethics in activity of the medical personnel of medical unit of internal affairs employees

M.V.Potapova, R.S.Mingazov

Abstract. In the article basic principles of ethics, deontology and etiquette which are closely connected among themselves are refected. Basic requirements of medical etiquette to the doctor of the Medical UNIT of the Ministry of Internal Affairs on the Republic of Tatarstan are formulated. The concept of a new interdisciplinary science — bioethics is given.

Key words: ethics, deontology, medical ethics, ethics of employees of the Ministry of Internal Affairs, etiquette, bioethics.

 

References

  1. Silujanova, I.V. Sovremennaja medicina i pravoslavie / I.V. Silujanova.—M.: Moskovskoe podvor'e Svjato-Troickoj Sergievoj lavry, 1998.
  2. Medicinskaja jetika i deontologija.—M., 1983.
  3. Deontologija v medicine.—M., 1988.
  4. Medicina i pravo.—M., 1999.
  5. Vklad vydajushhegosja russkogo jurista A.F. Koni v razvitie medicinskoj jetiki // Medicinskaja sestra. —1989.—№ 1.
  6. Gumanitarnaja sfera i prava cheloveka. Kniga uchitelja: sb. dokumentov / sost. V.A. Kornilov [i dr.].—M.: Prosveshhenie, 1992.
  7. Kar'era v medicine / ved. red. A. Jeliovich; otv. red. M. Shirokova.—M.: Avanta+, 2003.
  8. Medicinskoe pravo.—2008.—№ 4 (24).

 

 

ORIGINAL ARTICLES

PDF downloadEndothelial dysfunction in patients with chronic heart failure

N.A.Kosheleva, A.P.Rebrov

Abstract. One of the factors defning prognosis in patients with heart failure (CHF) is endothelial dysfunction. The aim of the given study was to defne antithrombogenic and vasolidating vascular wall activity in patients with CHF. 60 examined patients comprised two groups: the main group consisted of 40 patients after Q-myocardial infarction, the comparison group consisted of 20 patients. To determine antithrombogenic properties of vascular wall, «cuff testing» method developed by V.PBalouda was used. Endothelial vasomotor function was studied using probes with reactive hyperemia and nitroglycerin. In patients with CHF decrease of antithrombogenic and vasolidating vascular wall activity was observed. During six months of monitoring the number of repeated unfavorable cardiovascular events in patients with IV functional class CHF having long term CHF symptoms and EF value < 33% is reliably higher in comparison with patients of I, II and III functional classes of CHF.

Key words: chronic heart failure, endothelial dysfunction.

References

  1. Arbolishvili, G.N. Svjaz' razlichnyh pokazatelej variabel'nosti ritma serdca s mehanizmom smerti bol'nyh s hronicheskoj serdechnoj nedostatochnost'ju i sistolicheskoj disfunkciej levogo zheludochka / G.N. Arbolishvili, V.Ju. Mareev, Ju.N. Belenkov // Ser¬dechnaja nedostatochnost'.—2006.—№ 4(38).—S.172— 178.
  2. Solomon, S.D. Infuence of ejection fraction on cardiovascular outcomes in a broad spectrum of heart failure patients / S.D. Solomon, N. Anavecar, H. Skali [et al.] // Circulation.— 2005.—№ 112(24).—P.3738—3744.
  3. Mareev, V.Ju. Sravnitel'naja harakteristika bol'nyh s HSN v zavisimosti ot velichin frakcii vybrosa po rezul'tatam Rossijskogo mnogocentrovogo issledovanija JePOHA-O-HSN:
  4. snova o probleme HSN s sohrannoj sistolicheskoj funkciej levogo zheludochka / V.Ju. Mareev, M.O. Danieljan, Ju.N. Be-lenkov // Serdechnaja nedostatochnost'.—2006.—№ 112(38).— S.164—171.
  5. Ol'binskaja, L.I. Jendotelial'naja disfunkcija u bol'¬nyh ishemicheskoj bolezn'ju serdca, oslozhnennoj hro¬nicheskoj serdechnoj nedostatochnost'ju, i vozmozhnosti korrekcii izosorbid-5-mononitratom / L.I. Ol'binskaja, Zh.M. Sizova, A.V. Ushakova // Kardiologija.—2001.— № 3.—S.29—32.
  6. Peripheral vascular remodelling as a mechanism of exercise limitation in patients with chronic heart failure / Yu [et al.] // Eur. Heart. J.—1998.—№ 19.—P.65.
  7. Vizir, V.A. Perspektivy reversii jendotelial'noj dis¬funkcii u bol'nyh s zastojnoj serdechnoj nedostatochno¬st'ju / V.A. Vizir, A.E. Berezin // Klinicheskaja medicina.— 2000.—№ 7.—S.36—39.
  8. Baluda, V.P. Znachenie opredelenija antitrombogen-nyh svojstv stenki sosudov v profilaktike trombozov / V.P.Baluda, I.I.Dejanov // Kardiologija.—1988.— № 5.—S.103—104.
  9. Lieberman, E.H. Flow-induced vasodilation of the human brachial artery is impaired in patients / E.H. Lieberman, M.D. Gerhard, A. Uehata [et al.] // Am. J. Cardiol.—1996.— № 78.—P.22—27.
  10. Zatejshhikova, A.A. Jendotelial'naja reguljacija sosudistogo tonusa: metody issledovanija i klinicheskoe znachenie / A.A. Zatejshhikova, D.A. Zatejshhikov // Kardiologija.— 1998.—№ 9.—S.69—80.
  11. Cioff, G. Systemic thromboembolism in chronic heart failure. A prospective study in 406 patients / G. Cioff // Eur. Heart. J.—1996.—№ 17.—P.1381—1389.
  12. Vanhoutte, P.M. Endothelial dysfunction and atherosclerosis / P.M. Vanhoutte // Eur. Heart. J.—1997.—№ 18.—P.19— 29.

 

PDF downloadClinical and immunological evaluation of the recombinant human interleukine-2 (roncoleukin) efficiency in the treatment of mycoplasmal and chlamidia pneumonias

G.G.Mousalimova, V.N.Saperov, D.S.Markov, L.A.Voropayeva, A.R.Rakhimzyanov, Yu.M.Nagayeva

Abstract. There were 60 people under investigation: 44 among them having mycoplasmal pneumonia and 16 with chlamidia pneumonia. The investigated were divided into two groups. The frst group patients received traditional treatment (macrolideantibiotics, desintoxication and antioxidant therapy, bronchodilators, expectorant drugs). .Along with the traditional treatment the patients of the second group received immunity-modulating therapy. They got twice repeated drip intravenous injections of 500000 IU of Roncoleukin with the interval of 72 hours. In the result of our investigation, the patients with mycoplasmal and chlamidia pneumonias were revealed to have T-cell immunity depression, compensatory activation of humoral immunity and phagocytic neutrophilic activity. As a result of the traditional therapy, the T-cell depression was aggravated. The complex treatment with the usage of Roncoleukin led to the normalization of the essential quantitative and functional parameters of T-cell immunity, stabilized the humoral and neutrophilic phagocytosis. The immunity disorders elimination was correlated with the distinct clinical effect.

Key words: mycoplasmal and Chlamidia pneumonias, T-cell immunity, humoral immunity, phagocytic neutrophilic activity, immunity-modulating therapy, recombinant human interleukine-2 (Roncoleukin).

 

  1. ReferencesGlobal'naja strategija lechenija i profilaktiki bronhial'­noj astmy (peresmotr 2007 g.) / pod red. A.G. Chuchalina.—M.: Izdat. dom «Atmosfera», 2008.—108 s.
  2. Kaminskij, L.S. Medicinskaja i demograficheskaja statisti­ka / L.S. Kaminskij.—M.: Statistika, 1974.—S.27—99.
  3. Karzakova, L.M. Izuchenie immunnogo statusa naselenija, prozhivajushhego v promyshlenno-naselennoj zone Chuvashii / L.M. Karzakova, N.N. Van'kina [i dr.] // Immunodeficitnye sostojanija v klinike vnutrennih boleznej: tez. dokl. nauch.-prakt. konf., Cheboksary.—Cheboksary, 1999.—S.38.
  4. Malysheva, N.N. Immunnaja zashhita pri gormonal'no zavi­simoj bronhial'noj astme / N.N. Malysheva, R.Sh. Valiev, Z.M. Nehoroshkova [i dr.] // Problemy tuberkuleza.— 2000.—№ 2.—S.40—42.
  5. Medunicin, N.V. Citokiny i allergija, oposredovan­naja IgE / N.V. Medunicin // Immunologija.—1993.— № 5.—S.11—13.
  6. Potapnev, M.P. Molekuljarnye i kletochnye mehanizmy immunopatologii pri bronhial'noj astme / M.P.Potapnev, D.V.Pechkovskij // Pul'monologija.—1997.—№ 3.—S.74— 79.
  7. Spravochnik po immunoterapii dlja prakticheskogo vracha / pod red. A.S. Simbirceva.—SPb.: Dialog, 2002.— 480 s.
  8. Haitov, R.M. Allergologija i immunologija / R.M. Haitov, R.I. Il'ina.—M.: GJeOTAR-Media, 2009.—656 s.
  9. Haitov, R.M. Immunomoduljatory: mehanizm dejstvija i klinicheskoe primenenie / R.M. Haitov, B.V. Pinegin // Immunologija.—2003.—№3.—S.196—202.
  10. Chuchalin, A.G. Kortikozavisimaja forma bronhial'noj astmy / A.G. Chuchalin, B.I. Shmushkovich, D.Je. Mavraev // Terapevt. arhiv.—1984.—№ 3.—S.142—150.
  11. Boym, A. Separation of leucocytes from blood and bone marro / А. Boym // Scand. J. Clin. Lab. Invest.—1968.—№ 2, suppl. 87.—P.77—82.
  12. Barnes, P.J. Diffcult asthma / P.J.Barnes, A.J.Woolcock // Eur. Respir. J.—1998.—№. 12.—P.1209—1218.
  13. Romagnani, S. Human Th1 and Th2 subsets doubt no more / S.Romagnani // Immunol. today.—1991.—Vol. 12, № 8.— Р.256—257.
  14. Juniper, E.F. Quality-of-life considerations in the treatment of asthma / E.F.Juniper // PharmacoEconomies.—1995.— № 8.—Р.123—138.

 

PDF downloadEstimation of efficiency of recombinant human interleukine-2 (roncoleukin) in complex treatment of patients with steroid-dependent bronchial asthma

T.A. Nikonorova, O.V. Petrova, G.G.Mousalimova, V.N. Saperov, D.S. Markov, L.A. Voropayeva, A.R. Rakhimzyanov, Yu.M. Nagayeva

Abstract. The patients with steroid-dependent bronchial asthma were revealed to have T-cell immunity and depression of phagocyte and compensatory activation of humoral immunity. The complex treatment with the usage of roncoleukin led to the normalization of the basic quantitative and functional parameters of T-cell immunity, stabilized the humoral and neutrophilic phagocytosis. The removal of immunological disorders was accompanied by the expressed clinical effect.

Key words: steroid-dependent bronchial asthma, immunocorrecting therapy, recombinant human interleukine-2 (roncoleukin).

 

References

  1. Global'naja strategija lechenija i profilaktiki bronhial'¬noj astmy (peresmotr 2007 g.) / pod red. A.G. Chuchalina.—M.: Izdat. dom «Atmosfera», 2008.—108 s.
  2. Kaminskij, L.S. Medicinskaja i demograficheskaja statisti¬ka / L.S. Kaminskij.—M.: Statistika, 1974.—S.27—99.
  3. Karzakova, L.M. Izuchenie immunnogo statusa naselenija, prozhivajushhego v promyshlenno-naselennoj zone Chuvashii / L.M. Karzakova, N.N. Van'kina [i dr.] // Immunodeficitnye sostojanija v klinike vnutrennih boleznej: tez. dokl. nauch.-prakt. konf., Cheboksary.—Cheboksary, 1999.—S.38.
  4. Malysheva, N.N. Immunnaja zashhita pri gormonal'no zavi¬simoj bronhial'noj astme / N.N. Malysheva, R.Sh. Valiev, Z.M. Nehoroshkova [i dr.] // Problemy tuberkuleza.— 2000.—№ 2.—S.40—42.
  5. Medunicin, N.V. Citokiny i allergija, oposredovan¬naja IgE / N.V. Medunicin // Immunologija.—1993.— № 5.—S.11—13.
  6. Potapnev, M.P. Molekuljarnye i kletochnye mehanizmy immunopatologii pri bronhial'noj astme / M.P.Potapnev, D.V.Pechkovskij // Pul'monologija.—1997.—№ 3.—S.74— 79.
  7. Spravochnik po immunoterapii dlja prakticheskogo vracha / pod red. A.S. Simbirceva.—SPb.: Dialog, 2002.— 480 s.
  8. Haitov, R.M. Allergologija i immunologija / R.M. Haitov, R.I. Il'ina.—M.: GJeOTAR-Media, 2009.—656 s.
  9. Haitov, R.M. Immunomoduljatory: mehanizm dejstvija i klinicheskoe primenenie / R.M. Haitov, B.V. Pinegin // Immunologija.—2003.—№3.—S.196—202.
  10. Chuchalin, A.G. Kortikozavisimaja forma bronhial'noj astmy / A.G. Chuchalin, B.I. Shmushkovich, D.Je. Mavraev // Terapevt. arhiv.—1984.—№ 3.—S.142—150.
  11. Boym, A. Separation of leucocytes from blood and bone marro / A. Boym // Scand. J. Clin. Lab. Invest.—1968.—№ 2, suppl. 87.—P.77—82.
  12. Barnes, P.J. Diffcult asthma / P.J.Barnes, A.J.Woolcock // Eur. Respir. J.—1998.—№. 12.—P.1209—1218.
  13. Romagnani, S. Human Th1 and Th2 subsets doubt no more / S.Romagnani // Immunol. today.—1991.—Vol. 12, № 8.— R.256—257.
  14. Juniper, E.F. Quality-of-life considerations in the treatment of asthma / E.F.Juniper // PharmacoEconomies.—1995.— № 8.—R.123—138.

 

REVIEWS

PDF downloadResults of dynamic observation after patients with chronic obstructive pulmonary diseases during 2—5 years. Literature review

I.Yu. Vizel, E.I. Shmelev, A.A. Vizel

Department of Phthisiopulmonology, Kazan State Medical University, Kazan

Department of Pulmonology, Central Scientific-Research Institute of Tuberculosis, Moskow

Key words: chronic obstructive pulmonary disease, diagnosis, treatment, prognosis.

 

References

  1. Avdeev, S.N. Vlijanie dlitel'nogo priema N-acetilcisteina na chastotu obostrenij HOBL / S.N. Avdeev // Atmosfera: pul'monologija i allergologija.—2007.—№ 1(24).—S.12— 14.
  2. Vasil'eva, O.S. Hronicheskaja obstruktivnaja bolezn' legkih i professional'nye faktory / O.S. Vasil'eva // Pul'monologija.—2007.—№ 6.—S.5—11.
  3. Karoli, N.A. Prediktory riska smerti pacientov s HOBL (po rezul'tatam prospektivnogo dinamicheskogo nabljude­nija) / N.A. Karoli, A.P. Rebrov // Pul'monologija.—2007.— № 3.—S.77—80.
  4. Ryzhova, I.G. Spiriva (tiotropija bromid) — jeffektivnyj preparat dlja lechenija bol'nyh, stradajushhih hronicheskoj obstruktivnoj bolezn'ju legkih / I.G. Ryzhova, G.I. Fomen-kova // Terapevt. arhiv.—2006.—T. 78, № 3.—S.61—63.
  5. Sinopal'nikov, A.I. Jepidemiologija HOBL: sovremennoe sostojanie aktual'noj problemy / A.I. Sinopal'nikov, A.V. Vorob'ev // Pul'monologija.—2007.—№ 6.—S.78—84.
  6. Shmelev, E.I. Hronicheskaja obstruktivnaja bolezn' legkih i soputstvujushhie zabolevanija / E.I. Shmelev // Pul'monologija.—2007.—№ 2.—S.5—9.
  7. Shmelev, E.I. Hronicheskaja obstruktivnaja bolezn' legkih / E.I. Shmelev.—M., 2003.—112 s.
  8. Anthonisen, N.R. Prognosis in chronic obstructive pulmonary disease / N.R. Anthonisen, E.C. Wright, J.E. Hodgkin // Am. Rev. Respir. Dis.—1986.—Vol. 133, № 1.—P.14—20.
  9. Burge, P.S. Randomised, double blind, placebo controlled study of futicasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial / P.S. Burge, P.M. Calverley, P.W. Jones [et al.] // B. M. J.—2000.—Vol. 320, № 7245.—P.1297—1303.
  10. Bustamante-Fermosel, A. Mortality-related factors after hospitalization for acute exacerbation of chronic obstructive pulmonary disease: the burden of clinical features / A. Bustamante-Fermosel, J.M. De Miguel-Yanes, M. Duffort-Falcу, J. Muсoz // Am. J. Emerg. Med.—2007.—Vol. 25, № 5.—P.515—522.
  11. Calverley, P.M. TORCH investigators. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease / P.M. Calverley, J.A. Anderson, B. Celli [et al.] // N. Engl. J. Med.—2007.—Vol. 356, № 8.—P.775— 789.
  12. Casanova, C. The 6-min walking distance: the long-term follow up in patients with COPD / C. Casanova, C.G. Cote, J.M. Marin [et al.] // Europ. Resp. J.—2007.—Vol.29, № 3.—P.535—540.
  13. Donaldson, G.C. Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease / G.C. Donaldson, T.A. Seemungal, A. Bhowmik, J.A. Wedzicha // Thorax.—2002.—Vol. 57, № 10.—P.847— 852.
  14. Donaldson, G.C. Airway and systemic infammation and decline in lung function in patients with COPD / G.C. Donaldson, T.A. Seemungal, I.S. Patel [et al.] // Chest.—2005.—Vol. 128, № 4.—P.1995—2004.
  15. Feinlieb, M. Trends in COPD morbidity and mortality in the Unuted States / M. Feinlieb, N.M. Rosenberg, J.G. Collins [et al.] // Amer. Rev. Respir. Dis.—1989.—Vol. 140.—P.9—18.
  16. Geijer, R.M. Incidence and determinants of moderate COPD (GOLD II) in male smokers aged 40—65 years: 5-year follow up / R.M. Geijer, A.P. Sachs, T.J.Verheij [et al.] // Br. J. Gen. Pract.—2006.—Vol. 56, № 530.—P.656—661.
  17. Halbert, R.J. Global burden of COPD: systematic review and meta-analysis / R.J. Halbert, J.L. Natoli, A. Gano [et al.] // Eur. Respir. J.—2006.—Vol. 28, № 3.—P.523—532.
  18. Hilleman, D.E. Pharmacoeconomic evaluation of COPD / D.E. Hilleman, N. Dewan, M. Malesker [et al.] // Chest.—2000.— Vol. 118, № 5.—P.1278—1285.
  19. Hoogendoorn, M. A dynamic population model of disease progression in COPD / M. Hoogendoorn, M.P. Rutten van Molken, R.T. Hoogenveen [et al.] // Eur. Respir. J.—2005.— Vol. 26, № 2.—P.223—233.
  20. Lofdahl, C.G. Possible protection by inhaled budesonide against ischaemic cardiac events in mild COPD / C.G. Lofdahl, D.S. Postma, N.B. Pride [et al.] // Eur. Respir. J.—2007.— Vol. 29, № 6.—P.1115—1119.
  21. Lung Health Study Research Group. Effect of inhaled triamcinolone on the decline in pulmonary function in chronic obstructive pulmonary disease // N. Engl. J. Med.—2000.— Vol. 343, № 26.—P.1902—1909.
  22. Makris, D. Exacerbations and lung function decline in COPD: new insights in current and ex-smokers / D. Makris, J. Moschandreas, A. Damianaki [et al.] // Respir. Med.—2007.— Vol. 101, № 6.—P.1305—1312.
  23. Man, S.F. Inhaled corticosteroids in chronic obstructive pulmonary disease: is there a clinical beneft? / S.F. Man, D.D. Sin // Drugs.—2005.—Vol.65, № 5.—P.579—591.
  24. Mapel, D.W. Survival of COPD patients using inhaled corticosteroids and long-acting beta agonists / D.W. Mapel, J.S. Hurley, D. Roblin [et al.] // Respir. Med.—2006.—Vol. 100, № 4.—P.595—609.
  25. Miravitlles, M. Development of a large international survey of COPD through the internet. The EPOCA Project / M. Miravitlles, A.Anzueto, C.Murio [et al.] // Europ.Resp.J.—2006.—Vol. 28, suppl. 50.—Ref. P3939.
  26. Miravitlles, M. Effect of exacerbations on quality of life in patients with chronic obstructive pulmonary disease: a 2 year follow up study / M. Miravitlles, M. Ferrer, A. Pont [et al.] // Thorax.—2004.—Vol.59, № 5.—P.387—395.
  27. Naunheim, K.S. Long-term follow-up of patients receiving lung-volume-reduction surgery versus medical therapy for severe emphysema by the National Emphysema Treatment Trial Research Group / K.S Naunheim, D.E. Wood, Z. Mohsenifar [et al.] // Ann. Thorac. Surg.—2006.—Vol. 82, № 2.—P.431—443.
  28. Oga, T. Longitudinal deteriorations in patients with COPD / T. Oga, K.Nishimura, M.Tsukino // Respir. Med.—2007.— Vol. 101, № 1.—P.146—153.
  29. Parr, D.G. Infammation in sputum relates to progression of disease in subjects with COPD: a prospective descriptive study / D.G. Parr, A.J. White, D.L. Bayley [et al.] // Respir. Res.—2006.—Vol. 7, № 1.—P.136—148.
  30. Pierson, D.J. Clinical practice guidelines for chronic obstructive pulmonary disease: a review and comparison of current resources / D.J. Pierson // Respir. Care.—2006.—Vol. 51, № 3.—P.277—288.
  31. Pothirat, C. Clinical characteristics, management in real world practice and long-term survival among COPD patients of Northern Thailand COPD club members / C. Pothirat, N. Phetsuk, A. Deesomchok [et al.] // J. Med. Assoc. Thai.— 2007.—Vol. 90, № 4.—P.653—662.
  32. Reyes, N. Predictor factors of mortality in COPD patients / N. Reyes, M. Merino, I. Alfageme [et al.] // Europ.Resp. J.—2006.—Vol. 28, suppl. 50.—Ref. E4672.
  33. Seemungal, T. Investigating new standards for prophylaxis in reduction of exacerbations—the INSPIRE study methodology / T. Seemungal, R. Stockley, P. Calverley [et al.] // COPD.— 2007.—Vol. 4, № 3.—P.177—183.
  34. Sin, D.D. Mortality in COPD: role of comorbidities / D.D. Sin, N.R. Anthonisen, J.B. Soriano, A.G.Agusti // Eur. Respir. J.—2006.—Vol. 28, № 6.—P.1245—1257.
  35. Soler-Cataluсa, J.J. Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease / J.J. Soler-Cataluсa, M.A. Martнnez-Garcнa, P. Romбn Sбnchez [et al.] // Thorax.—2005.—Vol. 60, № 11.—P.925—931.
  36. Soriano, J.B. A pooled analysis of FEV1 decline in COPD patients randomized to inhaled corticosteroids or placebo / J.B. Soriano, D.D. Sin, X. Zhang [et al.] // Chest.—2007.— Vol. 131, № 3.—P.682—689.
  37. Soyseth, V. Statine use is associated with reduced mortally in COPD / V. Soyseth, P.H. Brekke, P. Smith, T. Omland // Eur. Respir. J.—2007.—Vol. 29, № 2.—P.279—283.
  38. Spencer, S. Health status deterioration in patients with chronic obstructive pulmonary disease / S. Spencer, P.M. Calverley, P. Sherwood-Burge, P.W. Jones // Am. J. Respir. Crit. Care Med.—2001.—Vol. 163, № 1.—P.122—128.
  39. Stratelis, G. The impact of repeated spirometry and smoking cessation advice on smokers with mild COPD / G. Stratelis, S. Molstad, P. Jakobsson, O. Zetterstrom // Scand. J. Prim. Health. Care.—2006.—Vol. 24, № 3.—P.133—139.
  40. Sutherland, E.R. Inhaled corticosteroids reduce the progression of airfow limitation in chronic obstructive pulmonary disease: a meta-analysis / E.R. Sutherland, H. Allmers, N.T. Ayas [et al.] // Thorax.—2003.—Vol. 58, № 11.—P.937—941.
  41. Takigawa, N. Distance and oxygen desaturation in 6-min walk test predict prognosis in COPD patients / N. Takigawa, E.R. Sutherland, H. Allmers, N.T. Ayas [et al.] // Respir. Med.— 2007.—Vol. 101, № 3.—P.561—567.
  42. Vestbo, J. Long-term effect of inhaled budesonide in mild and moderate chronic obstructive pulmonary disease: a randomised controlled trial / J. Vestbo, T. Sorensen, P. Lange [et al.] // Lancet.—1999.—Vol. 353, № 9167.—P.1819— 1823.
  43. Vollmer, W.M. Impact of regular inhaled corticosteroid use on chronic obstructive pulmonary disease outcomes / W.M. Vollmer, D. Peters, B. Crane [et al.] // COPD.—2007.— Vol. 4, № 2.—P.135—142.
  44. Washko, G.R. The effect of lung volume reduction surgery on chronic obstructive pulmonary disease exacerbations / G.R. Washko, V.S. Fan, S.D. Ramsey [et al.] // Am. J. Respir. Crit. Care Med.—2008.—Vol.177, № 2.—P.164—169.
  45. Watson, L. Predictors of lung function and its decline in mild to moderate COPD in association with gender: results from the Euroscope study / L. Watson, J.M. Vonk, C.G. Lofdahl [et al.] // Respir. Med.—2006.—Vol. 100, № 4.—P.746— 753.
  46. Wedzicha, J.A. INSPIRE Investigators. The prevention of chronic obstructive pulmonary disease exacerbations by salmeterol/futicasone propionate or tiotropium bromide / J.A. Wedzicha, P.M. Calverley, T.A. Seemungal [et al.] // Am. J. Respir. Crit. Care Med.—2008. —Vol. 177, № 1.—P.19— 26.
  47. Wilkinson, T.M. Respiratory syncytial virus, airway infammation and FEV1 decline in patients with chronic obstructive pulmo­nary disease / T.M. Wilkinson, G.C. Donaldson, S.L. Jonston [et al.] // Am. J. Respir. Crit. Care Med.—2006.—Vol. 173, № 8.—P.871—876.
  48. Wilson, L. Direct medical costs of chronic obstructive pulmonary disease: chronic bronchitis and emphysema / L. Wilson, E.B. Devine, K. So // Respir. Med.—2000.—Vol. 94, № 3.— P.204—213.
  49. Yarkin, T. Short- and long-term mortality of COPD patients treated in the respiratory intensive care unit for acute respiratory failure / T. Yarkin, D. Demiryontar, Z. Karakurt [et al.] // Europ. Resp. J.—2006.—Vol. 28, suppl. 50.—Ref. P2624.
  50. Zagdanska, R. FEV1 after three years of observation in patients with bronchial asthma and patients with chronic obstructive pulmonary disease / R. Zagdanska, I. Grzelewska-Rzymowska // Pneumonol. Alergol. Pol.—2005.—Vol. 73, № 2.—P.142— 147.

 

LECTURES

PDF downloadNon-specific ulcerative colitis: up-to-date approaches to diagnostics and treatment

S.R.Abdoulkhakov,R.A.Abdoulkhakov

Abstract. The article deals with classifcation, clinic, approaches to diagnostics and modern standards of non-specifc ulcerative colitis treatment, based on international and Russian recommendations. Criteria of assessment of severity stages of non-specifc ulcerative colitis according to Truelove/Witts and Mayo score; 5-ASA and corticosteroids recommended doses depending on severity stages; and indications for surgical treatment are presented.

Key words: non-specifc ulcerative colitis, assessment of activity and severity, treatment.

 

References

  1. Adler, G. Bolezn' Krona i jazvennyj kolit / G.Adler; per. s nem. A.A.Sheptulina.—M.: GJeOTAR-MED, 2001.—500 s.
  2. Belousova, E.A. Jazvennyj kolit i bolezn' Krona / E.A.Belousova.—M.: Triada, 2002.—130 s.
  3. Grigor'ev, P.Ja. Spravochnoe rukovodstvo po gastrojentero¬logii / P.Ja.Grigor'ev, Je.P.Jakovenko.—M.: Med. inform. agentstvo, 1997.—480 s.
  4. Grigor'eva, G.A. Nespecificheskij jazvennyj kolit i bo¬lezn' Krona: diagnostika i lechenie oslozhnennyh form / G.A.Grigor'eva, N.Ju.Meshalkina, I.B.Repina // Klinicheskie perspektivy gastrojenterologii, gepatologii.—2002.— № 5.—S.34—39.
  5. Masevich, C.G. Sovremennaja farmakoterapija hronicheskih vospalitel'nyh zabolevanij kishechnika / C.G.Masevich, S.I.Sitkin // Aqua Vitae.—2001.—№ 1.—S. 37—41.
  6. Rumjancev, V.G. Mestnaja terapija distal'nyh form jaz¬vennogo kolita / V.G.Rumjancev, V.A.Rogozina, V.A.Osina // Consilium-medicum.—2002.—T. 4, № 1.
  7. Sitkin, S.I. Mesalazin v terapii vospalitel'nyh za¬bolevanij kishechnika. Farmakokinetika i klinicheskaja jeffektivnost' / S.I.Sitkin // Gastrojenterologija Sankt-Peterburga.—2002.—№ 1.—S. 15.
  8. Halif, I.L. Vospalitel'nye zabolevanija kishechnika (ne¬specificheskij jazvennyj kolit i bolezn' Krona): klinika, diagnostika i lechenie / I.L.Halif, I.D.Loranskaja.—M.: Miklosh, 2004.—88 s.
  9. Shifrin, O.S. Sovremennye podhody k lecheniju bol'nyh nespecificheskim jazvennym kolitom / O.S.Shifrin // Consilium-medicum.—2002.—T. 4, № 6.—S.24—29.
  10. Hanauer, S.B. Renal safety of long-term mesalamine therapy in infammatory bowel disease (IBD) / S.B.Hanauer, C.Verst-Brasch, G.Regalli // Gastroenterology.—1997.—Vol. 112.— A991.
  11. Infammatory Bowel Disease: From Bench to Bedside / ed. by S.R.Targan, F.Shanahan, L.C.Karp.— 2nd ed.—Kluwer Academic Publishers, 2003.—904 p.
  12. Lamers, C. Comparative study of the topically acting glucocorticoid budesonide and 5-ASA enema therapy in proctitis and proctosigmoiditis / C.Lamers, J.Meijer, L.Engels // Gastroenterology.—1991.—Vol. 100.—A223.
  13. Lofberg, R. Oral budesonide versus prednisolone in apationts with active extensive and left-sided ulcerative colitis / R.Lofberg, A.Danielsson, O.Suhr // Gastroenterology.— 1996.—Vol. 110.—P.1713—1718.
  14. Marshall, J.K. Rectal corticosteroids versus alternative treatments in ulcerative colitis: a meta-analysis / J.K.Marshall, E.J.Irvine // Gut.—1997.— Vol. 40.—P. 775—781.
  15. Murch, S.H. Location of tumor necrosis factor alpha by immunohistochemistry in chronic inflammatory bowel disease / S.H.Murch // Gut.—1993.—Vol. 34 (12).—P.1705— 1709.
  16. Sutherland, L.R. Sulfasalazine revisited: a meta-analysis of 5-aminosalicylic in the treatment of ulcerative colitis / L.R.Sutherland, G.R.May, E.A.Shaffer // Ann. Intern. Med.— 1993.—Vol. 118.—P.540—549.
  17. Sutherland, L.R. Alternatives to sulfasalazine: a meta-analysis of 5-ASA in the treatment of ulcerative colitis / L.R.Sutherland, D.E.Roth, P.L.Beck // Infam. Bowel. Dis.—1997.—Vol. 3.— P.5—78.

 

PDF downloadDiagnosis and treatment of liver cirrhosis complications. Management of patients with edematicascitis syndrome

I.A.Gimaletdinova

Abstact: Clinical course of liver cirrhosis depends mostly on its complications: ascitis, hepatic encephalopathy, variceal
bleeding, etc. Methods of diagnosis of ascitis and ascitic  fuid, indications for treatment with diuretics, indications for paracentesis and surgical correction of portal hypertension as well as probable complications of treatment with diuretics are described in the article.

Key words: liver cirrhosis, ascitis, diuretics.

 

References

  1. Ivashkin, V.T. Bolezni pecheni i zhelchevyvodjashhih putej / V.T.Ivashkin.—M.: Vesti, 2002.
  2. Ivashkin, V.T. Racional'naja farmakoterapija zabolevanij organov pishhevarenija / V.T.Ivashkin.—M.: Izd-vo «Litter-ra», 2003.
  3. Okorokov, A.N. Diagnostika boleznej vnutrennih or¬ganov. Diagnostika boleznej organov pishhevarenija / A.N.Okorokov. — M.: Medicinskaja literatura, 2000.
  4. Okorokov, A.N. Lechenie boleznej vnutrennih organov. Le¬chenie boleznej organov pishhevarenija / A.N.Okorokov.—M.: Medicinskaja literatura, 2000.
  5. Podymova, S.D. Bolezni pecheni: rukovodstvo dlja vrachej / S.D.Podymova.—2 izd., pererab. dop.— M.: Medicina, 1993.
  6. Ivashkin, V.T. Kratkoe rukovodstvo po gastrojenterologii / V.T.Ivashkin, F.I.Komarov, S.I.Rapopport.—M.: Vesti, 2000.
  7. Kukes, V.G. Klinicheskaja farmakologija / V.G.Kukes.—M.: GJeOTAR-Media, 2008.
  8. Petrov, R.V. Spravochnik-putevoditel' praktikujushhego vracha: lekarstvennye sredstva / R.V.Petrov, L.E.Zi-ganshina.—M.: GJeOTAR-Med, 2003.
  9. Henderson, D.M. Patofiziologija organov pishhevarenija / D.M.Henderson.—SPb.: Izd-vo «Nevskij dialekt», 2001.
  10. Jakovleva, V.P. Racional'naja antimikrobnaja farmakotera¬pija / V.P.Jakovleva, S.V.Jakovlev.—M.: Izd-vo «Litterra», 2003.

 

BRIEF ARTICLES

PDF downloadAnalysis of results of screening examination of somatic patients for syphilis (on data of polyclinic of Ministry of Internal Affairs of RT)

L.K.Bounakova,E.F.Merikova

Polyclinic-Medico-Sanitary Departament of Ministry of Internal Affairs in the Republic of Tatarstan, Kazan

 

FOR GENERAL PRACTITIONER

PDF downloadProphylaxis, diagnostics and treatment of arterial hypertensia. Basic principles, tables, charts and commentaries to Russian recommendations of 2008 (to help the general physician)

N.B.Amirov

Department of General Medical Practice, Kazan State Medical Universy, Kazan

 

CLINICAL CASE

PDF downloadCase of successful thrombolysis in the patient with acute myocardial infarction of the left ventricle lower wall in settings of a non-specialized hospital

L.H.Safargaliyeva

Abstract. Clinical case of the patient with obesity, arterial hypertension with the subsequent development of myocardial infarction of the left ventricle lower wall. The diagnosis of inferior myocardial infarction was verifed with the help of ECG and clinical symptoms: acute pain in pericardial area, in the left part of thoracic cage.

Keywords: myocardial infarction, arterial hypertension, thrombolysis, reperfusion.