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Vol. 3 Issue 2 (2010)

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Editorial P.6

LEADING ARTICLE

The history of Therapy Sub-faculty № 1 of KSMA. Thread linking the times. R.G.Sayfoutdinov P.7

ORIGINAL ARTICLES

The Functional state of thyroid gland and severity of atherosclerosis in patients with coronary heart diseases. A.R.Volkova, O.A.Berkovich, E.I.Krasilnikova, S.V.Dora, E.V.Shlyakhto P.12

Arterial hypertension in pregnant women: pathogenesis, classification, approaches to treatment. N.S. Volchkova, S.F. Soubkhankoulova, A.F. Soubkhankoulova P.16

«Cost — effectiveness» evaluation of antihypertensive treatment in clinical practice. S.Z. Gabitov, A.S. Akhmadoullina, N.K. Touktamyshov, R.V. Yunousov P.20

Modern approach to diagnosis and treatment of occlusion damages of renal arteries. R.Kh. Galeyev, Sh.R. Galeyev P.24

EXPERIMENTAL MEDICINE TO PRACTICAL HEALTH CARE

Structural changes in pancreas of сats and pancreatic bloodstream at early stages of arterial circulation disturbance. R.K.Kadyrov P.30

Comparative assessment of application of acetylsalicylic acid and acetylsalicylic acid in combination with succinic acid in the patients with CHD. N.V.Kozhevnikova, R.G.Sayfoutdinov, T.N.Galioullina P.32

Depression, anxiety, and unstable angina pectoris. F.I. Belyalov, L.E.Maltseva, R.N.Yaguоdina. P. 35

Retrospective examination of patients with ischemic heart disease and the increased level of phospholipids-directed antibodies. R.R.Saifoutdinov, V.F.Bogojavlenskji, M.V.Gorina, R.G.Saifoutdinov P.37

Endotoxin and parameters of immune status in children with atopic dermatitis. B.A. Shamov P.38

The treatment of peptic ulcer disease with tonarol. R.B.Yunousov, S.Z.Gabitov, B.M.Chesnovskiy P.42

REVIEWS

Internal diseases and comorbidity. F.I. Belyalov P.44

Modern aspects of nonspecific ulcer colitis therapy from the standpoint of evidence medicine. Z.M.Galeyeva P.47

Doctrine of mechanical tunneling. Y.M. Ishenin P.51

CLINICAL CASE

The sick sinus syndrome in cardiology practice. R.G.Sayfoutdinov, E.V.Pak, A.F.Garipova, A.R.Gilyazova, S.Z.Gabitov, E.F.Roubanova, R.S.Nasyboullina P.55

The incidence of acute myocardial infarction complicated with interventricular septal rupture. R.G. Sayfoutdinov, S.Z. Gabitov, E.V. Pak, E.F. Roubanova, R.S. Nasyboullina, E.M. Mayorova, G.A. Moukhametshina, D.M. Sadykova P.64

HEALTH CARE ORGANIZATION

Organization of medical care in Germany. The principles and fundamentals of insurance medicine. D.-A.Reznikov P.66

LETTER TO THE EDITORIAL BOARD

L.M. Roshal P.73

Jubilee P.74

___

PDF downloadThe history of Therapy Sub-faculty № 1 of KSMA. Thread linking the times.

R.G.Sayfoutdinov

 

ORIGINAL ARTICLES

PDF downloadThe Functional state of thyroid gland and severity of atherosclerosis in patients with coronary heart diseases

A.R.Volkova, O.A.Berkovich, E.I.Krasilnikova, S.V.Dora, E.V.Shlyakhto

Abstract. Subclinical hypothyroidism (SH) very frequently occurs among elderly population. Even mild thyroid failure can promote the development and progression of heart ischemic disease. The results of coronarography (CG) reject severe coronary atherosclerosis. It seems to be very important to compare the results of CG with thyroid-stimulating hormone (TSH) level of heart ischemic disease patients. 489 patients participated in our study. CG was performed for all patients. We studied an age, a gender, a body mass index of patients, their smoking history, genetic predisposition. Fasting blood samples were taken for measuring TSH level. SH was revealed in 15,8% of women and 6,7% of men. Multivessel damage of coronary vessels correlated with man's gender, age, duration of smoking, genetic predisposition, hypertension and diabetes mellitus and TSH level is more than 4,0 IU/l (p=0,041, r=0,172). The truncal damage of left coronary artery was associated with elevation of TSH level. In patients with SH the truncal damage was revealed in 38% of cases, when in patients with normal TSH level only in 19,3%. In heart ischemic disease patients the SH was associated with woman's gender, elevation of BMI and severity of coronary atherosclerosis.

Key words: hypothyroidism, coronarograph, ischemic disease.

 

References

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  7. Rodondi, N. Subclinical hypothyroidism and the risk of coronary heart disease: a meta-analysis / N. Rodondi, D. Aujesky, E. Vittinghoff [et al.] // Am. J. Med. — 2006. — Vol. 119(7). — P.541—551.
  8. Walsh, J.P. Subclinical thyroid dysfunction as a risk factor for cardiovascular disease / J.P. Walsh, A.P. Bremner, M.K. Bulsara [et al.] // Arch. Intern. Med. — 2005. — Vol. 165 (21). — P.2467—2472.
  9. Auer, J. Thyroid function is associated with presence and severity of coronary atherosclerosis / J. Auer, R. Berent, T. Weber [et al.] // Clin. Cardiol. — № 26 (12). — P.569—573.
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  13. Razvi, S. The Benefcial Effect of L-Thyroxine on Cardiovascular Risk Factors, Endothelial Function, and Quality of Life in Subclinical Hypothyroidism: Randomized, Crossover / S. Razvi, L. Ingoe, G. Keeka // Trial. J. of Clin. Endocr.& Metab. —
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PDF downloadArterial hypertension in pregnant women: pathogenesis, classification, approaches to treatment

N.S. Volchkova, S.F. Soubkhankoulova, A.F. Soubkhankoulova

Abstract. In the given article the basic data about patogenesis, classifcations аrterial hypertension, risk factors of gestation
and approaches to treatment are refected.

Key words: arterial hypertension, pathоgenesis, pregnancy, gestation, hypertensive crisis, treatment.

 

References

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  2. Ajlamazjan, Je.K. Akusherstvo / Je.K. Ajlamazjan // Nacional'¬noe rukovodstvo / pod red. Je.K. Ajlamazjana, V.I. Kulakova, V.E. Radzinskogo, G.M. Savel'evoj. — M.: GJeOTAR-Media, 2007. — S.668—674.
  3. Apresjan, S.V. Beremennost' i rody pri jekstragenital'noj patologii / S.V. Apresjan; pod red. V.E. Radzinskogo. — M.: GJeOTAR-Media, 2009. — S.75—169.
  4. Diagnostika i lechenie arterial'noj gipertenzii. Rossij¬skie rekomendacii (tretij peresmotr) // Kardiovaskuljar- naja terapija i profilaktika. — 2008. — № 6. — 30 s. — Pril. 2.
  5. Makarov, O.V. Arterial'naja gipertenzija u beremennyh. Tol'ko li gestoz? / O.V. Makarov, N.N. Nikolaev, E.V. Vol¬kova. — M.: GJeOTAR-Media, 2006. — 174 s.
  6. Shehtman, M.M. Rukovodstvo po jekstragenital'noj pa¬tologii u beremennyh / M.M. Shehtman. — M.: Triada-H, 2008. — 815 s.
  7. Barabashkina, A.V. Novye podhody k lecheniju arterial'noj gipertonii v period beremennosti / A.V. Barabashkina // Rossijskij kardiologicheskij zhurnal. — 2005. — № 3. — S.47—52.
  8. Kulakov, V.I. Lekarstvennye sredstva, primenjaemye v akusherstve i ginekologii / V.I. Kulakov; pod red. V.I. Ku¬lakova, V.N. Serova, Ju.I. Barashneva. — M.: GJeOTAR-Med, 2004. — 66 s.
  9. Preobrazhenskij, D.V. Medikamentoznoe lechenie arte¬rial'noj gipertonii pri beremennosti / D.V. Preobra¬zhenskij, I.D. Vyshinskaja // Consilium medicum. — 2008. — T. 10, № 6. — S.46—50.
  10. Ushkalova, E.A. Lechenie arterial'noj gipertenzii vo vremja beremennosti / E.A. Ushkalova // Farmateka. — 2010. — № 1.

 

PDF download«Cost — effectiveness» evaluation of antihypertensive treatment in clinical practice

S.Z. Gabitov, A.S. Akhmadoullina, N.K. Touktamyshov, R.V. Yunousov

Abstract. The comparison ratio of the cost and effectiveness is the most recognized and widely used parameter for evaluating the pharmacoeconomic effectiveness of drugs. Preliminary comparison of the cost and effectiveness of antihypertensive therapy is necessary for further evaluation of the pharmacoeconomic coeffcient of effectiveness of used drugs. Implementeg by this way pharmacoeconomic investigation of angiotensin converting enzyme inhibitors, calcium channel blockers and β-adrenoblockers in 261 patients with essential hypertension of the 2nd—3rd stages, provided the most reliable comparative results.

Key words: arterial hypertension, «cost-effectiveness», antihypertensive drugs, pharmacoeconomic assessment.

 

References

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PDF downloadModern approach to diagnosis and treatment of occlusion damages of renal arteries

R.Kh. Galeyev, Sh.R. Galeyev

Abstract. This article is devoted to the problem of occlusion damages of renal arteries and caused by them complications. The aim of the research was to study frequency and structure of occlusion damages of renal arteries in patients with an arterial hypertension. With this aim in view, 494 observations of the patients with arterial hypertension were investigated. In 92 patients with the diagnosis of occlusion damages of renal arteries the effciency of various methods of surgical correction of the pathological process in renal artery, depending on its character and spread was defned.

Key words: arterial hypertension, renovascular disease, occlusion damages of renal arteries, renal failure.

 

References

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  2. Galeev, R.H. Chastota okkljuzirujushhih porazhenij pochechnyh arterij sredi bol'nyh arterial'noj gipertoniej // R.H. Ga-leev, Sh.R.Galeev, A.H Hadaan // Obshhestvennoe zdorov'e i zdravoohranenie. — 2009. — № 1. — S.61—65.
  3. Galjavich, A.S. Diagnostika i lechenie arterial'nyh giper¬tonij / A.S. Galjavich. — Kazan': GUP PIK «Idel'-Press», 2000. — 176 s.
  4. Nazarenko, G.I. Dopplerograficheskie issledovanija v uronefrologii / G.I. Nazarenko, A.N. Hitrova, T.V. Kras¬nova. — M.: Medicina, 2002. — 152 s.
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  6. Srirajaskanthan, R. Atherosclerotic renal artery stenosis — the challenge of patient mortality / R. Srirajaskanthan, D. Goldsmith // Journal of renovascular disease. — 2003. — Vol 2. — P.3—14.

 

EXPERIMENTAL MEDICINE TO PRACTICAL HEALTH CARE

PDF downloadStructural changes in pancreas of сats and pancreatic bloodstream at early stages of arterial circulation disturbance

R.K.Kadyrov

Abstract. Morphology of cat pancreas was studied by EPR- and MRI-spectroscopy during the experimental ischemia. The study was conducted on 38 animals, 3 animals were used as control group. The earliest changes in the structure of the pancreas occur within 5 minutes of ischemia; these changes can be reliably determined by spectroscopic methods.

Key words: pancreas, arterial circulation, ischemia, EPR-spectroscopy, MRI-spectroscopy.

 

References

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  9. Ruuge, Je.K. Redoks — sostojanie perenoschikov jelektron-transportnoj cepi mitohondrij serdca v uslovijah per¬fuzii — ishemii — reperfuzii: issledovanie metodom nizkotemperaturnoj JePR-spektroskopii / Je.K. Ruuge, V.L. Lakomkin, A.A. Timoshin // Biofizika. — 1997. — T. 42, № 6. — S.1240—1245.
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PDF downloadComparative assessment of application of acetylsalicylic acid and acetylsalicylic acid in combination with succinic acid in the patients with CHD

N.V.Kozhevnikova, R.G.Sayfoutdinov, T.N.Galioullina

Abstract. The infuence of the joint application of acetylsalicylic acid (ASA) and succinic acid on antiaggregatory platelet′s activity and endothelian dysfunction of the patients with CHD and cardiac insuffciency (CI) FC II-III is researched. Reliable improvement of these parameters in the examined patients in comparison with application ASA without succinic acid is elicited.

Key words: ASA, succinic acid, endothelian dysfunction, platelets disaggregation.

 

References

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  2. Galiullina, T.N. Teoreticheskoe i jeksperimental'noe obo¬snovanie sostava i tehnologii shipuchih i mnogokomponentnyh tabletok, soderzhashhih acetilsalicilovuju kislotu: avtoref. dis. … d-ra med. nauk / T.N. Galiullina. — Perm', 2003.
  3. Sovremennye aspekty protivovospalitel'noj terapii / R.S. Garaev, L.E. Ziganshina, V.N. Haziahmetova, R.H. Gu-merov, T.N. Galiullina // Terra Medica. — 1999. — № 3. — C.37—38.
  4. Kovalenko, A.L. Jantarnaja kislota: farmakologicheskaja aktivnost' i lekarstvennye formy / A.L. Kovalenko, N.V. Beljakova // Farmacija. —2000. — № 5/6. — S.40—42.
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  9. Aktaeva, I.N. Primenenie sukcinata natrija u bol'nyh, perenesshih infarkt miokarda / I.N. Aktaeva, V.Ja. Gulyj, I.E. Lihtenshtejn [i dr.] // Vrachebnoe delo. — 1985. — № 6. — S.6—8.
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PDF downloadDepression, anxiety, and unstable angina pectoris

F.I. Belyalov, L.E.Maltseva, R.N.Yaguоdina.

Abstract. Relations between depression, anxiety, somatic factors and unstable angina pectoris in 55 hospitalized patients are studied. Seattle Angina Questionnaire and Zung tests are used. Severity of angina pectoris depends on anxiety, depression and age, but not on somatic factors.

Key words: unstable angina pectoris, depression, anxiety.

 

References

  1. Beljalov, F.I. Diagnostika i lechenie psihicheskih ras¬strojstv u somaticheskih bol'nyh / F.I. Beljalov. — Irkutsk: RIO IGIUVa, 2009. — S.209—213.
  2. Smulevich, A.B. Psihokardiologija / A.B. Smulevich, A.L. Syrkin, M.Ju. Drobizhev, S.V. Ivanov. — M.: MIA, 2005. — 784 s.
  3. Hemingway, H. Evidence based cardiology: Psychosocial factors in the aetiology and prognosis of coronary heart disease: systematic review of prospective cohort studies / H. Hemingway, M. Marmot // BMJ. — 1999. — Vol. 318. — P.1460—1467.
  4. Shep, D.S. Depression, Anxiety and the Cardiovascular System: the Cardiologist's Perspective / D.S. Shep, D. Sheffeld // J. Clin. Psych. — 2001. — Vol. 62, suppl. 8. — P.12—16.
  5. Ibatov, A.D. Vlijanie trevozhnyh rasstrojstv na techenie ishemicheskoj bolezni serdca / A.D. Ibatov // Russkij med. zhurnal. — 2007. — T. 15, № 20. — S.1443—1446.
  6. Ruo, B. Depressive symptoms and health — related quality of life: the heart and soul study / B. Ruo, J.S. Rumsfeld, M.A. Hlatky [et al.] // JAMA. — 2003. — Vol. 290, № 2. — P.215— 221.
  7. Arnold, S.V. Psychosocial modulators of angina response to myocardial Ischemia / S.V. Arnold, J.A. Spertus, P.S. Cie-chanowski [et al.] // Circulation. — 2009. — Vol. 120, № 2. — P.126—133.
  8. Spertus, J.A. Development and evaluation of the Seattle Angina Questionnaire: a new functional status measure for coronary artery disease / J.A. Spertus, J.A. Winder, T.A. Dewhurst [et al.] // J. Am. Coll. Cardiol. — 1995. — Vol. 25, № 2. —P.333— 341.

 

PDF downloadRetrospective examination of patients with ischemic heart disease and the increased level of phospholipids-directed antibodies

R.R.Saifoutdinov, V.F.Bogojavlenskji, M.V.Gorina, R.G.Saifoutdinov

Abstract. Phospholipids-directed antibodies in patients with ischemic heart disease [exertional angina pectoris (EAP) and myocardial infarction (MI)] are investigated. An increase of the level of phospholipids-directed antibodies is revealed in all the patients. The severity of complications depends directly on the IgG level in the patients’ blood. The higher the level of phospholipids-directed antibodies, the heavier complications are expected in the patient. The correlation analysis between IgG and the contents of lymphocytes and thrombocytes in patients with ischemic heart disease is carried out.

Key words: ischemic heart disease, angina pectoris, antibodies to phospholipids, lymphocytes, thrombocytes.

 

References

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  2. Nasonov, E.L. Antifosfolipidnyj sindrom: diagnostika, klinika, lechenie / E.L. Nasonov // Russkij medicinskij zhurnal. — 1998 — T. 6, № 18. — S.1184—1188.
  3. Nasonov, E.L. Patologija sosudov pri antifosfolipidnom sindrome / E.L. Nasonov, A.A. Baranov, N.P. Shilkina, Z.S. Alekberova. — M.; Jaroslavl', 1995. — 162 s.
  4. Reshetnjak, T.M. Antitela k razlichnym fosfolipidam u bol'nyh SKV i pervichnym antifosfolipidnym sindromom / T.M. Reshetnjak, B. Vojcehovskaja, Z.S. Alekberova [i dr.] // Klinicheskaja medicina. — 1999. — № 5. — S.32—37.
  5. Musial, J. Valvular heart disease in systemic lupus erythematosus: another symptom of the disease or a hallmark of secondary antiphospholipid syndrome? / J. Musial // Eur. Heart J. — 1997. — Vol. 18(11). — P.1836—1837.
  6. Singh, K. The association of antiphospholipidantibodies with ischaemic stroke and myocardial infarction in young and their correlation: a preliminary study / K. Singh, M. Gaiha, D.K. Shome [et al.] // J. Assoc. Physicians India. — 2001. — Vol. 49. — P.527—529.

 

PDF downloadEndotoxin and parameters of immune status in children with atopic dermatitis

B.A. Shamov

Abstract. The high endotoxin level is established at an aggravation of atopic dermatitis in children. Its ambiguous interrelations with parameters of humoral and cellular link of immunity are revealed.

Key words: endotoxin, atopic dermatitis, immunity, children.

 

References

  1. Balabolkin, I.I. Atopicheskij dermatit u detej / I.I. Ba-labolkin, V.N. Grebenjuk. — M.: Medicina, 1999. — 240 s.
  2. Toropova, N.P. Jekzema i nejrodermit u detej (sovre¬mennye predstavlenija o patogeneze, klinike, lechenii i profilaktike) / N.P. Toropova, O.A. Sinjavskaja. —3-e izd. — Sverdlovsk, 1993. — 447 s.
  3. Anihovskaja, I.A. Kishechnyj jendotoksin kak universal'nyj faktor adaptacii i patogeneza obshhego adaptacionnogo sindroma / I.A. Anihovskaja, O. N. Oparina, M.M. Jakovleva [i dr.] // Fiziologija cheloveka. — 2006. — № 2. — S. 87— 91.
  4. Permjakov, N.K. Patologija organov pishhevarenija i sistem¬naja jendotoksinemija / N.K. Permjakov, M.Ju. Jakovlev // Arhiv patologii. — 1989. — № 12. — S.74—79.
  5. Jakovlev, M.Ju. Uspehi teoreticheskoj mediciny. Rol' sistemnoj jendotoksinemii v fiziologii i patologii che¬loveka / M.Ju. Jakovlev. — 1995. — S.10—11.
  6. Morrison, D.C. Endotoxin and disease mechanisms / D.C. Morrison, J.L. Ryan // Ann. Rev. Med. — 1987. — Vol. 38. — P.417—432.
  7. Leung, D.Y. Atopic dermatitis and the immune system: the role of superantigen and bacteria / D.Y. Leung // J. Am. Acad. Dermatol. — 2001. — Vol. 45. — S.6—13.
  8. Olson, N.C. Biochemical, physiological and clinical aspects of endotoxaemia / N.C. Olson // Mol. Aspects Med. — 1988. — Vol. 10, № 6. — P.511—629.
  9. Yakovlev, M.Yu. Endotoxin theory of human physiology and pathology: systemic endotoxinemia, endotoxin aggression and endotoxin insuffciency / M.Yu. Yakovlev // J. Endotoxin research. — 2000. — Vol. 6, № 2. — P.120.

 

 

PDF downloadThe treatment of peptic ulcer disease with tonarol

R.B.Yunousov, S.Z.Gabitov, B.M.Chesnovskiy

Abstract. Tonarol in treatment of patients with рeptic ulcer disease demonstrated healing acceleration of ulcer defect, diminishing a number of Неlicobacter pylori microbes and improving clinical state of patients.

Key words: рeptic ulcer disease, Неlicobacter pylori, tonarol.

 

References

  1. Bobyrev, V.N., Voskresenskij O.N. // Terapevticheskij arhiv. — 1989. — № 3. — S.122—125.
  2. Bronovec, I.N. Spravochnik po gastrojenterologii / I.N. Bro-novec, I.I. Goncharik, E.P. Demidchik, M.N. Sarkovich. — Minsk, 1998.
  3. Burlakova, E.B. Bioantioksidant / E.B. Burlakova. — Tju¬men', 2007. — S.3—4.
  4. Burlakova, E.B. Bioantioksidant / E.B. Burlakova // Tez. dokl. V Mezhdunar. konf., 18—20 nojabrja 1998 g. — M., 2008. — S.1—2.
  5. Vorob'ev, E.A. Bioantioksidant / E.A. Vorob'ev, N.G. Tre¬t'jak, E.N. Savenko // Tez. dokl. III Vsesojuzn. konf., 27—29 ijunja 1998 g. — M., 1998. —T. II. — S.188—189.
  6. Grigor'ev, P.Ja., Jakovenko A.V. // Klinicheskaja gastrojente¬rologija. — M., 1998.

 

REVIEWS

PDF downloadInternal diseases and comorbidity

F.I. Belyalov

Abstract. In this article the author has made systematic review of psychosomatic factors in common somatic diseases. The role of psychic state in somatic diseases diagnostics, course, severity assessment, progosis and therapy is diseussed.

Key words: internal medicine, comorbidity.

 

References

  1. Caughey, G.E. Prevalence of comorbidity of chronic diseases in Australia / G.E. Caughey, A.I. Vitry, A.L. Gilbert, E.E. Roughead // BMC Public Health. — 2008. — Vol. 8. — P.221.
  2. Aronow, W.S. Prevalence of CAD, complex ventricular arrhythmias, and silent myocardial ischemia and incidence of new coronary events in older persons with chronic renal insuffciency and with normal renal function / W.S. Aronow [et al.] // Am. J. Card. — 2000. — Vol. 86. — P.1142—1143.
  3. AHA/NKF. Detection of chronic kidney disease in patients with or at increased risk of cardiovascular disease // Circulation. —2006. — Vol. 114. — P.1083—1087.
  4. Van den Akker, M. Multimorbidity in general practice: prevalence, incidence, and determinants of co-occurring chronic and recurrent diseases / M. Van den Akker, F. Buntinx, J.F. Metsemakers [et al.] // J. Clin. Epidemiol — 1998. — Vol. 51, № 5. — P. 367—375.
  5. Australian Institute of Health and Welfare (AIHW): Chronic diseases and associated risk factors in Australia. — Canberra: ACT, 2006.
  6. Berenguer, M. Viral Hepatitis / M. Berenguer, T.L. Wright // Feldman: sleisenger & fordtran's gastrointestinal and liver disease — 7th ed. — 2002.
  7. Gonzalez, A. Do cardiovascular risk factors confer the same risk for cardiovascular outcomes in rheumatoid arthritis patients as in non-rheumatoid arthritis patients? / A. Gonzalez, H.M. Kremers, C.S. Crowson [et al.] // Ann. Rheum. Dis. — 2008. — Vol. 67. — P.64—69.
  8. Miguel, A. Comorbidity and mortality in peritoneal dialysis: a comparative study of type 1 and 2 diabetes versus nondiabetic patients. peritoneal dialysis and diabetes / A. Miguel, R. Garcia-Ramon, J. Perez-Contreras [et al.] // Nephron. — 2002. — Vol. 90, № 3. — P.290—296.
  9. Marti, S. Body weight and comorbidity predict mortality in COPD patients treated with oxygen therapy / S. Marti, X. Munoz, J. Rios [et al.] // Eur. Respir. J. — 2006. — Vol. 27, № 4. — P.689—696.
  10. Sin, D.D. Chronic obstructive pulmonary disease as a risk factor for cardiovascular morbidity and mortality / D.D. Sin, S.F.P. Man // Proc. Am. Thorac. Soc. — 2005. — Vol. 2. — P.8— 11.
  11. Kiss, D. Bronchial asthma causing symptoms suggestive of angina pectoris / D. Kiss, W. Veegh, D. Schragel [et al.] // Eur. Respir. J. — 2003. — Vol. 21, № 3. — P.473—477.
  12. Edmondstone, W.M. Chest pain and non-respiratory symptoms in acute asthma / W.M. Edmondstone // Postgrad. Med. J. — 2000. — Vol. 76, № 897. — P.413—414.
  13. Braithwaite, R.S. A Framework for tailoring clinical guidelines to comorbidity at the point of care / R.S. Braithwaite, J. Concato, C.C. Chang [et al.] // Arch. Intern. Med. — 2007. — Vol. 167, № 21. — P.2361—2365.
  14. K/DOQI Clinical practice guidelines for managing dyslipidemias in chronic kidney disease. — 2003.
  15. Cates, C.J. Regular treatment with formoterol for chronic asthma: serious adverse events. Cochrane Database of Systematic Reviews / C.J. Cates, M.J. Cates, T.J.Lasserson. — 2008. — Issue 4.
  16. Salpeter, S.R. Meta-analysis: effect of long-acting {beta}-agonists on severe asthma exacerbations and asthma-related Deaths / S.R. Salpeter, N.S. Buckley, T.M. Ormiston [et al.] // Ann. Intern. Med. — 2006. — Vol. 144. — P.904—912.
  17. Antman, E.M. Use of nonsteroidal antiinfammatory drugs. An update for clinicians. A scientifc statement from the American Heart Association / E.M. Antman, J.S. Bennett, A. Daugherty [et al.] // Circulation. — 2007. — Vol. 115, № 12. — P.1634— 1642.
  18. IDSA/ATS Community Acquired Pneumonia Guidelines. — 2007.
  19. Bont, J. Is co-morbidity taken into account in the antibiotic management of elderly patients with acute bronchitis and COPD exacerbations? / J. Bont, E. Hak, C.E. Birkhoff [et al.] // Fam. Pract. — 2007. — Vol. 24, № 4. — P.317—322.
  20. Takeuchi, K. No adverse effect of non-steroidal anti-infammatory drugs, sulindac and diclofenac sodium, on blood pressure control with a calcium antagonist, nifedipine, in elderly hypertensive patients / K. Takeuchi, K. Abe, M. Yasujima [et al.] // The Tohoku Journal of Experimental Medicine. — 1991. — Vol. 165. — P.201—208.
  21. Struijs, J.N. Comorbidity in patients with diabetes mellitus: impact on medical health care utilization / J.N. Struijs, C.A. Baan, F.G. Schellevis [et al.] // BMC Health. Serv. Res. — 2006. — Vol. 6. — P.84.
  22. Zhang, M. Comorbidity and repeat admission to hospital for adverse drug reactions in older adults: retrospective cohort study / M. Zhang, C.D. Holman, S.D. Price [et al.] // BMJ. — 2009. — Vol. 338. — P.a2752.
  23. Kongkaew, C. Hospital admissions associated with adverse drug reactions: a systematic review of prospective observational studies / C. Kongkaew, P.R. Noyce, D.M. Ashcroft // Ann. Pharmacother. — 2008. — Vol. 42, № 7. — P.1017—1025.
  24. Passarelli, M.C. Adverse drug reactions in an elderly hospitalised population: inappropriate prescription is a leading cause / M.C. Passarelli, W. Jacob-Filho, A. Figueras // Drugs Aging. — 2005. — Vol. 22, № 9. — P.767—777.
  25. Bayliss, E.A. Descriptions of barriers to self-care by persons with comorbid chronic diseases / E.A. Bayliss, J.F. Steiner, D.H. Fernald [et al.] // Ann. Fam. Med. — 2003. — Vol. 1, № 1. — P.15—21.
  26. Wang, P.S. Effects of noncardiovascular comorbidities on antihypertensive use in elderly hypertensives / P.S. Wang, J. Avorn, M.A. Brookhart [et al.] // Hypertension. — 2005. — Vol. 46, № 2. — P.273—279.
  27. Groot, V. de. How to measure comorbidity: a critical review of available methods / V. de Groot, H. Beckerman, G. Lankhorst [et al.] // J. Clin. Epidmiol. — 2003. — Vol. 56. — P.221— 229.
  28. Charlson, M.E. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation / M.E. Charlson, P. Pompei, K.L. Ales, C.R. McKenzie // J. Chron. Dis. — 1987. — Vol. 40, № 5. — P.373—383.
  29. Starfeld, B. Comorbidity: Implications for the Importance of Primary Care in 'Case' Management / B. Starfeld, K.W. Lemke, T. Bernhardt [et al.] // Ann. Fam. Med. — 2003. — Vol. 1, № 1. — P.8—14.
  30. Boyd, C.M. Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performance / C.M. Boyd, J. Darer, C. Boult [et al.] // JAMA. — 2005. —Vol. 294, № 6. — P.716—724.
  31. Weel, C. van. Comorbidity and guidelines: conficting interests / C. van Weel, F.G. Schellevis // Lancet. — 2006. — Vol. 367. — P.550—551.

 

PDF downloadModern aspects of nonspecific ulcer colitis therapy from the standpoint of evidence medicine

Z.M.Galeyeva

Abstract. This article demonstrated modern aspects of conservative therapy of nonspecifc ulcer colitis in the context of
evidence medicine.

Key words: infammatory diseases of bowels, nonspecifc ulcer colitis, evidence medicine.

 

References

  1. Adler, G. Bolezn' Krona i jazvennyj kolit / G. Adler. — M.: GJeOTAR-Medicina, 2001. — S.527.
  2. Sanborn, W.J. // Infamm Bowel Dis. — 2005. — Vol. 5, № 1. — P.48—63.
  3. Campieri, M. Effcacy of 5-aminosalicylic acid enemas versus hydrocortisone enemas in ulcerative colitis / M. Campieri, P. Gionchetti, A. Belluzzi [et al.] // Dig. Dis. Sci. — 2007. — № 32. — P.67—70.
  4. Cohen, R.D. A meta-analysis and overview of the literature on treatment options for left-sided ulcerative colitis and ulcerative proctits / R.D. Cohen, D.M. Woseth, R.A. Thisted, S.B. Hanauer // Am. J. Gastroenterol. — 2000. — № 95. — P.1263—1276.
  5. Gionchetti, P. Comparison of oral with rectal mesalazine in the treatment of ulcerative proctitis / P. Gionchetti, F. Rizzello, A. Venturi [et al.] // Dis. Colon. Rectum. — 1998. — № 41. — P.93—97.
  6. Hanauer, S.B. Dose-ranging study of mesalamine (PENTASA) enemas in the treatment of acute ulcerative proctosigmoiditis: results of a multicentered placebo-controlled trial. The U.S PENTASA Enema Study Group / S.B. Hanauer. — Infamm. Bowel. Dis. — 2006. — № 4. — P.79—83.
  7. Marshall, J.K., Irvine E.J. // Gut. — 2007. — № 40. — P.775— 781.
  8. Oshitani, N. Corticosteroids for the management of ulcerative colitis / N. Oshitani, A. Kitano, T. Matsumoto, K. Kobayashi // J. Gastroenterol.—2005.—Vol. 5, № 30 (suppl. 8).—P.118—120.
  9. Stack, W.A. Short- and long-term outcome of patients treated with cyclosporin for severe acute ulcerative colitis / W.A. Stack, R.G. Long, C.J. Hawkwy // Aliment. Pharmacol. Ther. — 2005. — № 12. — P.973.
  10. Sutherland, L. Oral 5-aminosalicylic acid for inducing remission in ulcerative colitis / L. Sutherland, D. Roth, P. Beck, K. Makiyama // Cochrane Database Syst. Rev. — 2008.

 

PDF downloadDoctrine of mechanical tunneling

Y.M. Ishenin

Abstract. In work the scientifc-clinical researches on technology of mechanical tunneling on a material of 1526 operations at various ischemic syndromes of bodies and fabrics are presented. In research it is presented last materials of application of cellular technologies in treatment of an ischemic heart trouble, a cirrhosis, an ischemia of lower extremities, limfodema and others. The main moment of work was the conclusion that tunneling — the new surgical doctrine, allowing to carry out system diagnostics and surgical screening without which medical process becomes the vicious and socially dangerous phenomenon.

Key words: mechanical tunnel, ischemic disease.

 

References

  1. Izimbergenov, N.I. Ispol'zovanie SO2-lazera v hirur¬gicheskom lechenii cirroza pecheni / N.I. Izimbergenov // Aktual'nye voprosy organizacii pomoshhi bol'nym por¬tal'noj gipertenziej. — Alma-Ata, 1991. — S.119—122.
  2. Ishenin, Ju.M. Modelirovanie i hirurgicheskoe lechenie ishemicheskih sostojanij miokarda: dis. … d-ra med. nauk / Ju.M. Ishenin. — M., 1990. — 316 s.
  3. Ishenin, Ju.M. Mehanicheskoe tunnelirovanie i stvolovye kletki kostnogo mozga v hirurgii IBS: jeksperimental'no-klinicheskoe issledovanie / Ju.M. Ishenin // Singraal'naja hirurgija. — 2004. — № 3/4. — S.8—15.
  4. Ishenin, Ju.M. Hirurgija cirroza pecheni / Ju.M. Ishenin, A.V. Potapov, V.M. Chesnovskij [i dr.]. — Nizhnekamsk, 2005. — 174 s.
  5. Ishenin, Ju.M. Retunnelirovanie i implantacija al-loplanta u bol'noj cirrozom pecheni / Ju.M. Ishenin [i dr.]. — Ros. zhurnal gastrojenterologii, gepatologii, kolono-proktologii. — 2004. — T. 14, № 1. — S.38.
  6. Ishenin, Ju.M. Tunnelirovanie pochek v jeksperimente / Ju.M. Ishenin, A.A. Andrjukov, A.D. Klimenko [i dr.]. — Singraal'naja hirurgija. — 2000. — № 2/3. — S.45—46.
  7. Ishenin, Ju.M. Kriticheskie sostojanija v medicine / Ju.M. Ishenin // Singraal'naja hirurgija. — 2001. — № 2/3.
  8. Ishenin, Ju.M. Pervyj opyt hirurgicheskogo lechenija zlokachestvennoj vazorenal'noj gipertenzii metodom tunnelirovanija / Ju.M. Ishenin // Singraal'naja hirurgija. — 2008. — № 3/4. — S.4—15.
  9. Kaskad konferencij // Singraal'naja hirurgija. — 2004. — № 3/4. — S.78—87.
  10. Chaj, V.A. Hirurgicheskoe lechenie diabeticheskoj angio-patii metodom tunnelirovanija / V.A. Chaj, E.E. Tulebaev, A.A. Jasakova, K.S. Murzabekov // Aktual'nye voprosy hirurgii. — Cheljabinsk, 1999. — S.327—328.

 

CLINICAL CASE

PDF downloadThe sick sinus syndrome in cardiology practice

R.G.Sayfoutdinov, E.V.Pak, A.F.Garipova, A.R.Gilyazova, S.Z.Gabitov, E.F.Roubanova, R.S.Nasyboullina

Abstract. The article represents clinical cases of sick sinus syndrome, the etiology, clinical and electrocardiographic diagnostics and indications for cardiac pacing.

Key words: sick sinus syndrome, diagnostics, electro cardiac pacing.

 

References

  1. Dzhanashija, P.H. Sindrom slabosti sinusovogo uzla / P.H. Dzhanashija, N.M. Shevchenko, N.D. Dzhanashija // Serdce. — T. 1, № 2. — 2009. — S.97—99.
  2. Zhdanov, A.M. Pokazanija k jelektricheskoj stimuljacii serd¬ca pri bradikardicheskih narushenijah ritma / A.M. Zhdanov, F.B. Votchal, O.V. Korostyleva // Serdce. — T. 1, № 2. — 2009. — S.92—93.
  3. Kushakovskij, M.S. Aritmii serdca / M.S. Kushakovskij. — SPb.: Foliant, 2004. — S.440—443, 446—450.
  4. Perepech, N.B. Kardiologija / N.B. Perepech, S.I. Rjabov. — SPb., 2008. —T. 1. — S.494—498, 582—583.
  5. Rukovodstvo po jelektrokardiografii. — M.: Medicinskoe informacionnoe agentstvo, 2004. — S.352—353.

 

PDF downloadThe incidence of acute myocardial infarction complicated with interventricular septal rupture

R.G. Sayfoutdinov, S.Z. Gabitov, E.V. Pak, E.F. Roubanova, R.S. Nasyboullina, E.M. Mayorova, G.A. Moukhametshina, D.M. Sadykova

Abstract. The patient with acute myocardial infarction complicated with interventricular septum rupture was supervised for 5 years. Successful surgical plastic treatment and revascularization wеre conducted with subsequent installation of permanent pacemaker.

Key words: myocardial infarction, interventricular septum rupture, left ventricular aneurysm, coronary angiography, coronary artery bypass granfting permanent pacemaker.

 

HEALTH CARE ORGANIZATION

PDF downloadOrganization of medical care in Germany. The principles and fundamentals of insurance medicine

D.-A.Reznikov

Abstract. German social security, established by German Chancellor Bismark in 1881, the oldest in Europe. In all countries of the European Community health system is based on the principle of social, insurance medicine. State has transmitted health management to corporative, self-government organizations: the medical organizations-the medical Chambers, hospitals, physician’s private practices and compulsory health insurance fund. Medical Association is fully responsible for the results of treatment and effective use of allocated funds. Double fnancing of medical care in Germany is carried out both by the compulsory health insurance (FOMS), and by grants from the State budget in countries with developed system of insurance reinforced methods of industrial management organization in health (DRG)-Diagnose Related group. Post-graduate training — physician’s- pulmonologist begins upon graduation from higher medical education and passes in ordinate in the workplace. Post-graduate training doctors in Germany is in establishing land physician Chambers. Time of postgraduate education (internal medicine with specialization) in the pneumology for a period of 72 months. It exists mark system of credits for raising the level of pulmonologist`s skills.

Key words: insurance medicine, corporative management system, continuous postgraduate training of physicians.

 

References

  1. Tätigkeitsbericht der Bundesärztekammer. — 2008.
  2. Berufsordnung für nordrheinischen Ärztinnen und Ärzte.
  3. Heilberufsgestz NRW.
  4. Bundesärztekammer Fort und Weiterbildungsordnung.
  5. Kassenärztliche Vereinigung-Gesetze, Satzungen, Verträge.
  6. Dr. Morar, Mutter, Keller-Krankenhausmanagement im DRG-Zeitalter. — 2002.
  7. Dr. jur. T. Quiel Rechtliche und strukturelle Rahmenbedingungen der Krankenhдuser (Vortragsrehe 2007).
  8. Statistisches Bundesamt Wiesbaden (HRG) Gesund­heitswesens. — 2007.
  9. Bundesärztekammer — Curriculum Krankenhausmanagement Weiterbildung des MIBEG-Instituts, Köln. — 2007.